CN104807986A - Clinic medical symptom screening reagent kit - Google Patents
Clinic medical symptom screening reagent kit Download PDFInfo
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- CN104807986A CN104807986A CN201510249128.6A CN201510249128A CN104807986A CN 104807986 A CN104807986 A CN 104807986A CN 201510249128 A CN201510249128 A CN 201510249128A CN 104807986 A CN104807986 A CN 104807986A
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- China
- Prior art keywords
- reagent
- reagents
- symptom
- substrate
- medical symptom
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
- G01N33/523—Single-layer analytical elements the element being adapted for a specific analyte
Abstract
The invention provides a clinic medical symptom screening reagent kit, which comprises various reagents, a plurality of substrates and a reagent distributor, wherein the reagents are used for indicating different medical symptoms; when the substrates receives one reagent in various reagents, the first color can be shown; when the body fluid of a user with the specific medical symptom is added to the substrate, the color of the substrate can be changed from a first color to a second color; the reagent distributor is used for adding one reagent in various reagents onto one substrate; the regents have different dosages, and the dosages correspond to the detection frequency of the medical symptoms indicated by different reagents.
Description
Technical field
The present invention relates to a kind of kit, especially relate to a kind of clinical medicine symptom kit for screening.
Background technology
In prior art, medical personnel pass through the detection for body fluid such as blood, urine, saliva etc., for diagnosing the medical symptom of patient.To in the detection of these body fluid, kit is a kind of pick-up unit of routine.Generally include the test paper prepared in conventional kit, test paper changes color when receiving patient body fluid, makes medical personnel can judge the medical symptom of patient according to the color change of test paper.
The normally many test papers of test paper in existing kit, such as, for the measurement of urine, usually use and survey Urine test paper more, and this Urine test paper just by plurality of reagents lamination, can carry out examination to other analytes reaching 8 kinds in urine when producing.Such as, but when practical application, medical personnel may only want to carry out a kind of or two kinds detection, test for protein and glucose test to patient.Test by the urine of routine, medical personnel will be forced to use and survey Urine test paper more, and this Urine test paper is typically configured to carry out examination to nearly 8 kinds other analytes in urine.The Urine test paper of these routines is used to be a kind of wastes to material and money.
In order to solve the problem, 201280032981.7 patent of invention propose a kind of the detection kit, this kit comprises multiple skip test bar and plurality of reagents, by distributing different reagent on skip test bar, for detecting different medical symptoms.That it changes the mode that can make test-strips, provide necessary component to set up the customization test-strips of low cost to medical personnel, these test-strips can be used to the clinical diagnosis of patient and effectively this patient be carried out to the examination of plurality of medical symptom.
But, 201280032981.7 invention also there is following problem, on the one hand, in its technical scheme, the dosage of various reagent is the same, but in clinical diagnosis, frequency different symptoms being needed to diagnosis is different, may cause during such use, a certain reagent is finished and causes kit to use, and other reagent also has residue, thus causes the waste of reagent; On the other hand, if when patient detects that certain symptom occurs positive, may also will continue to detect for this symptom later, cause the reagent dosage of this symptom very large, cause reagent to run low very much.And the invention of 201280032981.7 cannot solve the problem.The present invention, as the improvement of 201280032981.7, can solve the problem.
Summary of the invention
As one aspect of the present invention, provide a kind of clinical medicine symptom kit for screening, comprising: plurality of reagents, be used to indicate different medical symptom; Multiple substrates, described substrate is when to receive in described plurality of reagents a kind of, and can present the first color, when adding the body fluid of the user with certain medical symptom to above-mentioned substrate, the color of this substrate can become the second color from the first color change; Reagent distributor; For adding the one in described plurality of reagents to a substrate; It is characterized in that: have different dosage in described plurality of reagents, described dosage corresponds to the detection frequency of different reagent place instruction medical symptom.
Preferably, in technique scheme, described dosage is different according to the different phase of user's disease.
Preferably, in technique scheme, the different phase of described dosage pregnancy duration residing for user and different.
Preferably, in technique scheme, the first reagent in described plurality of reagents has the first dosage, and described first dosage corresponds to user when occurring positive in the first medical symptom that this kind of reagent is corresponding detects, and needs the dosage of the frequency detected.
Preferably, in technique scheme, the second reagent in described plurality of reagents has the second dosage, and described second dosage corresponds to user when occurring positive in the second medical symptom that this kind of reagent is corresponding detects, and needs the dosage of the frequency detected.
Preferably, in technique scheme, described first medical symptom and the second medical symptom are two symptoms that are medically mutually related.
Preferably, in technique scheme, described first medical symptom is ketoacidosis, and the second medical symptom is diabetes.
Preferably, in technique scheme, described first reagent is ketone reagent, and the second reagent is glucose reagent.
Preferably, in technique scheme, described substrate comprises the first substrate and the second substrate, the every a slice in described first substrate is used for the detection of the reagent except the first reagent and the second reagent, and described second substrate is used for the first reagent and the second reagent detects simultaneously.
Preferably, in technique scheme, described second substrate is greater than the first substrate, is less than the twice of the first substrate.
Preferably, in technique scheme, described second substrate is arranged two regions, first area is used for the detection of the first reagent, and second area is used for the detection of the second reagent.
As another aspect of the present invention, provide a kind of preparation method of clinical medicine symptom kit for screening, described medical symptom kit for screening comprises: plurality of reagents, is used to indicate different medical symptom; Multiple substrates, described substrate is when to receive in described plurality of reagents a kind of, and can present the first color, when adding the body fluid of the user with certain medical symptom to above-mentioned substrate, the color of this substrate can become the second color from the first color change; Reagent distributor; For adding the one in described plurality of reagents to a substrate; The first reagent in described plurality of reagents has the first dosage, and described first dosage corresponds to user when occurring positive in the first medical symptom that this kind of reagent is corresponding detects, and needs the dosage of the frequency detected; Described preparation method comprises the steps: to prepare above-mentioned plurality of reagents; Prepare multiple substrates above-mentioned; Preparation mentioned reagent divider; Plurality of reagents, multiple substrates and reagent distributor are assembled, generate polytype medical symptom kit for screening of varying number, when the dissimilar one corresponded in different medical symptom in described polytype medical symptom kit for screening detects and occurs positive, the medical symptom kit for screening of corresponding types; Wherein: polytype medical symptom kit for screening number ratio of described varying number corresponds to the ratio of different medical symptom generation.
Embodiment
The present invention will be described further in conjunction with specific embodiments, and these examples only for illustration of object, and are not used in the restriction scope of the invention.
Embodiment one:
The invention provides a kind of clinical medicine symptom kit for screening, comprise plurality of reagents, multiple substrates, reagent distributor and packing box.Each wherein in plurality of reagents is used to indicate different medical symptom, have been found that eurypalynous diagnosis and/or screening agent are all applicable to use together with the present invention perhaps, such as in obstetrics are detected, can the existence of examination following substances: albumen, glucose, nitrite, leucocyte, ketoboidies, cholerythrin and urobilinogen, separately add proportion and the pH level of this body fluid of inspection.
Multiple substrates, described substrate is when to receive in described plurality of reagents a kind of, and can present the first color, when adding the body fluid of the user with certain medical symptom to above-mentioned substrate, the color of this substrate can become the second color from the first color change.Such as, the protein reagent in 201280032981.7 is used, when protein concentration scope is in 0.3-0.4g/L from yellow to blueness.
Reagent distributor, for adding the one in above-mentioned plurality of reagents to a substrate.Packing box, its inside has spatial accommodation, described spatial accommodation for holding mentioned reagent, substrate and reagent distributor.
As the contribution of the present invention for prior art, have different dosage in the plurality of reagents in the present invention, dosage corresponds to the detection frequency of different reagent place instruction medical symptom.Such as, in obstetrics' inspection, each detection all needs to detect albumen, and glucose detection only needs to detect once, just no longer need after qualified to detect, therefore, can by reagent, the amount of reagent of Protein Detection is set to comparatively large, and the amount of reagent of glucose detection is set to less.Thus when making reagent detect, the consumption of all reagent is all comparatively even, avoids the waste of reagent.Preferably, due to the different phase in disease, the detection frequency of various symptom is also different, such as, obstetrics pregnancy duration different phase and the frequency that detects is different.Therefore, according to the different stages, the dosage of various reagent can be set, make the kit being used in different phase and using.
When patient occurs positive for the diagnosis of certain symptom, such as, when diabetic symptom appears in pregnant woman, periodic detection may be needed later.Therefore, for this situation, the glucose reagent in plurality of reagents can be set to there is the first dosage, when described first dosage corresponds to user's diabetes appearance positive, need the dosage of the frequency detected.In clinical detection, be medically mutually related two symptoms, and such as ketoacidosis and gestational diabetes mellitus, often may exist simultaneously.Therefore, the ketone reagent in plurality of reagents can be had the second dosage, when described second dosage corresponds to the ketoacidosis appearance positive, need the dosage of the frequency detected.Because these two kinds of symptoms need to detect simultaneously, substrate can be set to comprise the first substrate and the second substrate, every a slice in described first substrate is used for the detection of the reagent except glucose reagent and ketone reagent, and the every a slice in described second substrate is used for glucose reagent and ketone reagent detects simultaneously.Preferably, above-mentioned second substrate is arranged two regions, first area is used for the detection of the first reagent, and second area is used for the detection of the second reagent.The area of above-mentioned second substrate is greater than the first substrate, is less than the twice of the first substrate.
Embodiment two:
A preparation method for clinical medicine symptom kit for screening, described medical symptom kit for screening comprises: plurality of reagents, is used to indicate different medical symptom; Multiple substrates, described substrate is when to receive in described plurality of reagents a kind of, and can present the first color, when adding the body fluid of the user with certain medical symptom to above-mentioned substrate, the color of this substrate can become the second color from the first color change; Reagent distributor; For adding the one in described plurality of reagents to a substrate; The first reagent in described plurality of reagents has the first dosage, and described first dosage corresponds to user when occurring positive in the first medical symptom that this kind of reagent is corresponding detects, and needs the dosage of the frequency detected; Described preparation method comprises the steps: to prepare above-mentioned plurality of reagents; Prepare multiple substrates above-mentioned; Preparation mentioned reagent divider; Plurality of reagents, multiple substrates and reagent distributor are assembled, generate polytype medical symptom kit for screening of varying number, when the dissimilar one corresponded in different medical symptom in described polytype medical symptom kit for screening detects and occurs positive, the medical symptom kit for screening of corresponding types; Polytype medical symptom kit for screening number ratio of described varying number corresponds to the ratio of different medical symptom generation.By the technical scheme of embodiment two, in process of production, the occurrence rate for different medical symptom produces dissimilar medical symptom kit for screening number, thus effectively can improve the utilization rate of reagent.
In the art, know for other reagent used together with test paper and test-strips, and be applicable to using together with kit for screening of the present invention.To be not described further a bit, but think that they also belong within the scope of the invention.In all documents incorporated by reference all in this application that the present invention mentions, just quoted separately as a reference as each section of document.In addition should be understood that those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after having read above-mentioned instruction content of the present invention.
Claims (10)
1. a clinical medicine symptom kit for screening, comprising: plurality of reagents, is used to indicate different medical symptom; Multiple substrates, described substrate is when to receive in described plurality of reagents a kind of, and can present the first color, when adding the body fluid of the user with certain medical symptom to above-mentioned substrate, the color of this substrate can become the second color from the first color change; Reagent distributor, for adding the one in described plurality of reagents to a substrate; It is characterized in that: have different dosage in described plurality of reagents, described dosage corresponds to the detection frequency of different reagent place instruction medical symptom.
2. clinical medicine symptom kit for screening according to claim 1, is characterized in that: described dosage is different according to the different phase of user's disease.
3. clinical medicine symptom kit for screening according to claim 2, is characterized in that: the different phase of described dosage pregnancy duration residing for user and different.
4. clinical medicine symptom kit for screening according to claim 3, it is characterized in that: the first reagent in described plurality of reagents has the first dosage, described first dosage corresponds to user when occurring positive in the first medical symptom that this kind of reagent is corresponding detects, and needs the dosage of the frequency detected.
5. clinical medicine symptom kit for screening according to claim 4, it is characterized in that: it is characterized in that: the second reagent in described plurality of reagents has the second dosage, described second dosage corresponds to user when occurring positive in the second medical symptom that this kind of reagent is corresponding detects, and needs the dosage of the frequency detected.
6. clinical medicine symptom kit for screening according to claim 5, is characterized in that: described first medical symptom and the second medical symptom are two symptoms that are medically mutually related.
7. clinical medicine symptom kit for screening according to claim 6, it is characterized in that: described first medical symptom is ketoacidosis, the second medical symptom is diabetes; Described first reagent is ketone reagent, and the second reagent is glucose reagent.
8. a preparation method for clinical medicine symptom kit for screening, comprises the steps: to prepare above-mentioned plurality of reagents; Prepare multiple substrates above-mentioned; Preparation mentioned reagent divider; Plurality of reagents, multiple substrates and reagent distributor are assembled, generate polytype medical symptom kit for screening of varying number, when the dissimilar one corresponded in different medical symptom in described polytype medical symptom kit for screening detects and occurs positive, the medical symptom kit for screening of corresponding types; It is characterized in that: polytype medical symptom kit for screening number ratio of described varying number corresponds to the ratio of different medical symptom generation.
9. preparation method according to claim 8, is characterized in that: described medical symptom kit for screening comprises: plurality of reagents, is used to indicate different medical symptom; Multiple substrates, described substrate is when to receive in described plurality of reagents a kind of, and can present the first color, when adding the body fluid of the user with certain medical symptom to above-mentioned substrate, the color of this substrate can become the second color from the first color change; Reagent distributor; For adding the one in described plurality of reagents to a substrate; The first reagent in described plurality of reagents has the first dosage, and described first dosage corresponds to user when occurring positive in the first medical symptom that this kind of reagent is corresponding detects, and needs the dosage of the frequency detected.
10. a clinical medicine symptom kit for screening, comprising: plurality of reagents, is used to indicate different medical symptom; Multiple substrates, described substrate is when to receive in described plurality of reagents a kind of, and can present the first color, when adding the body fluid of the user with certain medical symptom to above-mentioned substrate, the color of this substrate can become the second color from the first color change; Reagent distributor, for adding the one in described plurality of reagents to a substrate; Packing box, its inside has spatial accommodation, described spatial accommodation for holding mentioned reagent, substrate and reagent distributor.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510249128.6A CN104807986B (en) | 2015-05-16 | 2015-05-16 | Clinical medicine symptom kit for screening |
| CN201610145029.8A CN105675603B (en) | 2015-05-16 | 2015-05-16 | A kind of clinical symptoms kit for screening |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510249128.6A CN104807986B (en) | 2015-05-16 | 2015-05-16 | Clinical medicine symptom kit for screening |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610145029.8A Division CN105675603B (en) | 2015-05-16 | 2015-05-16 | A kind of clinical symptoms kit for screening |
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| Publication Number | Publication Date |
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| CN104807986A true CN104807986A (en) | 2015-07-29 |
| CN104807986B CN104807986B (en) | 2016-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510249128.6A Expired - Fee Related CN104807986B (en) | 2015-05-16 | 2015-05-16 | Clinical medicine symptom kit for screening |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102116771A (en) * | 2010-01-04 | 2011-07-06 | 深圳市亚辉龙生物科技有限公司 | Enzyme-linked immune analysis method and fully-automatic enzyme-linked immune analyzer |
| US20120275956A1 (en) * | 2011-04-28 | 2012-11-01 | Yuji Wakamiya | Sample analyzer and storage medium |
| CN103649749A (en) * | 2011-05-06 | 2014-03-19 | 约翰霍普金斯大学 | Point-of-care, medical condition screening kit |
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2015
- 2015-05-16 CN CN201510249128.6A patent/CN104807986B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102116771A (en) * | 2010-01-04 | 2011-07-06 | 深圳市亚辉龙生物科技有限公司 | Enzyme-linked immune analysis method and fully-automatic enzyme-linked immune analyzer |
| US20120275956A1 (en) * | 2011-04-28 | 2012-11-01 | Yuji Wakamiya | Sample analyzer and storage medium |
| CN103649749A (en) * | 2011-05-06 | 2014-03-19 | 约翰霍普金斯大学 | Point-of-care, medical condition screening kit |
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| CN104807986B (en) | 2016-06-29 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Inventor after: Luan Qingxin Inventor after: Zhang Binguo Inventor before: Jia Xiaoqing |
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Effective date of registration: 20160520 Address after: 266011 Shandong province Qingdao City, Jiaozhou Road No. 1 Applicant after: Qingdao Municipal Hospital Address before: 050051 Heping West Road, Hebei, Shijiazhuang, No. 348 Applicant before: Jia Xiaoqing |
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Granted publication date: 20160629 Termination date: 20170516 |