CN104799827A - Applanation type measuring device and applanation type measurement method for biomechanical property of cornea - Google Patents
Applanation type measuring device and applanation type measurement method for biomechanical property of cornea Download PDFInfo
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Abstract
The invention discloses an applanation type measuring device for the biomechanical property of cornea. The device comprises a supporting structure, a guide rod, a micro stepping motor, a pressure sensor, a displacement sensor, an optical area detection probe, a signal acquiring device and a signal processing and controlling device, wherein one end of the micro stepping motor and a fixed end of the displacement sensor are respectively sequentially mounted on the supporting structure; the other end of the micro stepping motor and a measuring end of the displacement sensor are respectively sequentially mounted on the guide rod; the fixed end of the pressure sensor is mounted on the guide rod; the measuring end is mounted on the optical area detection probe; the pressure sensor, the displacement sensor and the optical area detection probe are respectively in communication with the signal acquiring device; the signal acquiring device is in communication connection with the signal processing and controlling device; the signal processing and controlling device is in communication connection with the micro stepping motor. The invention also discloses a method for the applanation type measuring device to measure the biomechanical property of the cornea.
Description
Technical field
The present invention relates to its biological mechanical meaurement device technique field, particularly relate to a kind of its biological mechanical property planishing type measuring device and measuring method.
Background technology
Myopia is the most common cause causing human eye vision Quality Down, is one of oculopathy that within the scope of the world today, sickness rate is the highest.According to statistics, China's myopia number nearly 400,000,000, ranks first in the world.Myopia belongs to ametropia, the primary treatment scheme that myopia correction ametropia adopts clinically is cornea refractive surgery, the present whole world has the patient of more than 6,000,000 to accept near-sighted excimer laser cornea refractive surgery every year, and the amount for surgical that wherein China is annual just reaches 80 to 100 ten thousand examples.Refractive surgery mainly by changing the rigidity of the curvature of cornea, shape and cornea, causing the redistribution of cornea stress within the eye, changing the effective elasticity of cornea by this under pressure effect, thus changes refractive power, reaches the object regulating its refracting power.Laser in Situ Keratomileusis (laser in situ keratomileusis, LASIK) be the current whole world most widely used general, carry out maximum myopia cornea refractive surgeries.LASIK remains corneal epithelium and bowman's lamina owing to performing the operation, its design comparatively meets the anatomical physiology characteristic of eye cornea, but the postoperative complication that bulge can occur to expand forward under physiological environment of cornea is appeared in the newspapers, there is the extensive concern that development mechanism causes doctor and scholar in it, generally believes that corneal ectasia phenomenon changes relevant with the biomechanical property of cornea.Under the effect of physiological environment intraocular pressure, due to comea fibrous minimizing, its resistance will reduce, and comea fibrous reduction directly may affect the rigidity of cornea.In order to improve operation skill and quality, computer is utilized to carry out digital human eye or the preoperative modeling and simulating research of LASIK comparatively necessity, but being different from common engineering material due to cornea, the individual biomechanical property of its uniqueness will determine accuracy and the reliability of results of numerical model calculation.Cornea is biologic soft tissue material, has the biomechanical properties such as delayed, lax, creep.Existing its biological mechanical property test method has the perfusion method of testing of cornea pulling method, keratectasia method, Through Optical Interference Spectra and whole eyeball.Cornea pulling method is cut into strip or ring-shaped sample the residue Perforation after corneal graft, carry out single shaft or biaxial tension experiment by controlling different draw ratios, the biomechanics characteristics such as the stress-strain of corneal, stress relaxation and croop property have carried out research.The perfusion test rule of keratectasia method, Through Optical Interference Spectra and whole eyeball the cornea extractd is fixed on sealing cell or directly adopts in vitro (corpse) intact eye, by puncturing into the linker regulation and control of anterior chamber, the biomechanical property situations such as the corneal elasticity modulus under acting under different intraocular pressure and ocular rigidity are detected.These technology are all that corneal is measured in vitro due to the method adopted, and thus destroy the intrinsic physiological environment of cornea and architectural feature, fully can not reflect the biomechanical property of physiological environment cornea.Current clinical ophthalmology lacks and non-destructive can directly obtain the consistent biomechanical property detection technique of physiology duty actual in cornea and data, thus lacks the abundant understanding to individual cornea deformation mechanism.
Summary of the invention
The present invention proposes a kind of its biological mechanical property planishing type measuring device and measuring method, described measuring device is simple, the non-invasive planishing type of its biological mechanical property can be realized measure, integration evaluation is carried out to the biomechanical property of the individual cornea of physiological environment, measurement result fully can react the biomechanical property of physiological environment cornea, and measuring method is accurate.
A kind of its biological mechanical property planishing type measuring device that the present invention proposes, comprises supporting construction, guide rod, micro-step motor, pressure transducer, displacement transducer, area detection optic probe, signal pickup assembly and signal processing and control device; One end of micro-step motor and the stiff end of displacement transducer are installed on the support structure respectively successively, and the other end of micro-step motor and the measuring junction of displacement transducer are arranged on guide rod respectively successively; The stiff end of pressure transducer is arranged on guide rod, and measuring junction is arranged on area detection optic probe, and micro-step motor drives guide rod to move, and guide rod drives displacement transducer and pressure transducer to move, and pressure transducer drives area detection optic probe to move; Displacement transducer can change in displacement signal between perception its stiff end and measuring junction, and pressure transducer can the pressure change signal of its stiff end of perception and measuring junction, area detection optic probe detectable angle membrane area variable signal.
The signal output part of area detection optic probe, pressure transducer and displacement transducer is connected with the signal input part communication of signal pickup assembly respectively, and the change in displacement signal of perception is sent to signal pickup assembly by the pressure change signal of perception and displacement transducer by the cornea area change signal of detection, pressure transducer by area detection optic probe; The signal output part of signal pickup assembly is connected with the signal input part communication of control device with signal processing, and signal processing and control device obtain change in displacement signal, pressure change signal and cornea area change signal by signal pickup assembly; Signal processing is connected with the signal input part communication of micro-step motor with the signal output part of control device, and signal processing and control device control micro-step motor work according to change in displacement signal, pressure change signal and cornea area change signal.
Preferably, area detection optical measuring head comprises cylindrical shell, and is fixedly connected on the light source of one end in cylindrical shell; And to be located in cylindrical shell and the light that light source is launched successively through collimating lens, spectroscope and luminous flux compensation mirror; And being fixedly connected with cylindrical shell one end away from light source, and the round platform prism that the light through luminous flux compensation mirror is injected; And to be located in cylindrical shell and to be positioned at spectroscope side, and accept successively through cylindrical mirror that round platform prism transmission, the transmission of luminous flux compensation mirror and dichroic mirror light are injected; And to be located in cylindrical shell and to be positioned at cylindrical mirror away from spectroscopical side, and the photodetector through cylindrical mirror light can be received; The cornea area change signal that photodetector on area detection optic probe can be detected is delivered to signal pickup assembly.
Preferably, pressure transducer is arranged on the cylindrical shell of area detection optical measuring head.
Preferably, micro-step motor comprises motor lead screw, and micro-step motor is arranged on guide rod by motor lead screw.
Preferably, supporting construction is provided with crossbeam, and the stiff end of micro-step motor and displacement transducer is arranged on the crossbeam of supporting construction respectively successively.
The invention allows for a kind of method that its biological mechanical property planishing type measuring device carries out measuring, comprise the steps:
Enabling signal process and control device control micro-step motor work, and micro-step motor drives guide rod to move, and guide rod drives displacement transducer and pressure transducer to move, and pressure transducer drives area detection optic probe to move; The area of signal A of detection is gathered by signal pickup assembly by displacement transducer by the displacement signal W of perception, pressure transducer by the pressure signal F of detection and area detection optical measuring head, then the signal of Real-time Collection is sent into signal processing and control device process by signal pickup assembly, signal processing and control device real-time synchronization obtain cornea and are out of shape and flatten displacement Wi (i=1,2, ..n), cornea distortion flattening pressure Fi (i=1,2, ..n), cornea distortion applanation area Ai (i=1,2 ..n).
Preferably, above-mentioned its biological mechanical property planishing type measuring device carries out the method measured, and comprises the steps:
S1, adjustment area detection optical measuring head position, make its round platform prism centers aim at corneal vertex;
S2, corneal hysteresis performance, cornea stiffness measurement: control micro-step motor work by signal processing and control device, and then drive area detection optic probe to move with corneal applying step loads, first carry out N CYCLIC LOADING-unloading, complete presetting, wherein N is greater than 0 and is integer, preferred N is 1,2,3,4,5,6,7,8 or 9, and preferably N is 3 further; The cornea obtained according to signal processing in N+1 CYCLIC LOADING-uninstall process and control device is out of shape flattening pressure Fi and cornea and is out of shape and flattens displacement Wi, and drafting Fi-Wi curve, completes corneal hysteresis Performance Detection; Linear fit Fi-Wi curve, obtains cornea stiffness parameters;
S3, cornea relaxation property detect: control micro-step motor work by signal processing and control device, and then drive area detection optic probe to flatten cornea, when cornea distortion flattens displacement Wi=0.1-0.2mm, when preferred Wi is 0.15mm, signal processing and control device control micro-step motor and quit work; Within the after this t=0-1800s time, the cornea utilizing signal processing and control device real-time synchronization to obtain is out of shape flattening pressure Fi (i=1,2 ..n) and draws and show Fi-t curve, completes cornea relaxation property and measures;
S4, cornea croop property detect: control micro-step motor work by signal processing and control device, and then drive area detection optic probe to flatten cornea, as cornea distortion flattening pressure Fi=0.02-0.05N, when preferred Fi is 0.03N, signal processing and control device control micro-step motor and quit work; Within the after this t=0-1800s time, the cornea utilizing signal processing and control device real-time synchronization to obtain is out of shape and flattens displacement Wi (i=1,2 ..n) and draw and show Wi-t curve, completes cornea croop property and measures;
S5, intraocular pressure detect: control micro-step motor work by signal processing and control device, and then drive area detection optic probe to flatten cornea, cornea distortion applanation area Ai=6-8mm
2time, preferred Ai is 7.35mm
2time, signal processing and control device control micro-step motor and quit work; The cornea utilizing signal processing and control device real-time synchronization to obtain is out of shape flattening pressure Fi (i=1,2 ..n), cornea is out of shape applanation area Ai (i=1,2 ..n) and draws and show Fi/Ai-t curve, completes intraocular pressure Dynamic Acquisition; Utilize Ai=6-8mm
2time corresponding Fi numerical value, preferred Ai is 7.35mm
2time, according to Fi/Ai calculate survey eyeball physiological environment intraocular pressure value.
In the present invention, by area detection optical measuring head, pressure transducer and displacement transducer, the distortion of Real-time Obtaining cornea applanation area, flattening pressure and pressing displacement data, realize corneal hysteresis performance, cornea rigidity, cornea relaxation property, cornea croop property and intraocular pressure synchronous detecting, integration evaluation can be carried out to the biomechanical property of the individual cornea of physiological environment, realize the non-invasive planishing type of its biological mechanical property to measure, this measuring device is simple, and measuring method is accurate.The present invention can increase clinicist and research worker to the understanding of physiological environment cornea deformation mechanism, for physiological environment corneal material this enough equation builds, the plan of myopia cornea refractive surgery and post-operative evaluation provide science reference.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of its biological mechanical property planishing type measuring device provided by the invention;
Fig. 2 is round platform prism side view provided by the invention;
Fig. 3 is area detection optical measuring head operation principle schematic diagram provided by the invention;
Fig. 4 is step loading mode schematic diagram provided by the invention;
Fig. 5 is cornea croop property curve synoptic diagram provided by the invention;
Fig. 6 is the method flow schematic diagram that a kind of its biological mechanical property planishing type measuring device that the present invention proposes carries out measuring.
Detailed description of the invention
As shown in Fig. 1,2,3,4,5,6, Fig. 1 is the structural representation of a kind of its biological mechanical property planishing type measuring device provided by the invention, Fig. 2 is round platform prism side view provided by the invention, Fig. 3 is area detection optical measuring head operation principle schematic diagram provided by the invention, Fig. 4 is step loading mode schematic diagram provided by the invention, Fig. 5 is cornea croop property curve synoptic diagram provided by the invention, and Fig. 6 is the method flow schematic diagram that a kind of its biological mechanical property planishing type measuring device that the present invention proposes carries out measuring.
With reference to Fig. 1, the its biological mechanical property planishing type measuring device that the present invention proposes, comprises supporting construction 12, guide rod 15, micro-step motor 4, pressure transducer 2, displacement transducer 3, area detection optic probe 1, signal pickup assembly 17 and signal processing and control device 18; One end of micro-step motor 4 and the stiff end of displacement transducer 3 are arranged in supporting construction 12 respectively successively, and the other end of micro-step motor and the measuring junction of displacement transducer 3 are arranged on guide rod 15 respectively successively; The stiff end of pressure transducer 2 is arranged on guide rod 15, measuring junction is arranged on area detection optic probe 1, micro-step motor 4 drives guide rod 15 to move, and guide rod 15 drives displacement transducer 3 and pressure transducer 2 to move, and pressure transducer 2 drives area detection optic probe 1 to move; Displacement transducer 3 can change in displacement signal between perception its stiff end and measuring junction, and pressure transducer 2 can the pressure change signal of its stiff end of perception and measuring junction, area detection optic probe 1 detectable angle membrane area variable signal;
The signal output part of area detection optic probe 1, pressure transducer 2 and displacement transducer 3 is connected with the signal input part communication of signal pickup assembly 17 respectively, and the change in displacement signal of perception is sent to signal pickup assembly 17 by the pressure change signal of perception and displacement transducer 3 by the cornea area change signal of detection, pressure transducer 2 by area detection optic probe 1; The signal output part of signal pickup assembly 17 is connected with the signal input part communication of control device 18 with signal processing, and signal processing and control device 18 obtain change in displacement signal, pressure change signal and cornea area change signal by signal pickup assembly 17; Signal processing is connected with the signal input part communication of micro-step motor 4 with the signal output part of control device 18, and signal processing and control device 18 control micro-step motor 4 according to change in displacement signal, pressure change signal and cornea area change signal and work.
In a specific embodiment, supporting construction 12 is provided with crossbeam 13, and the stiff end of micro-step motor 4 and displacement transducer 3 is arranged on the crossbeam 13 of supporting construction 12 respectively successively; Micro-step motor 4 comprises motor lead screw 14, and the measuring junction of micro-step motor 4 is arranged on guide rod 15 by motor lead screw 14, and the measuring junction of displacement transducer uses threaded connection 16 to be fixed on guide rod 15.
Area detection optical measuring head 1 comprises cylindrical shell, and is fixedly connected on the light source 5 of one end in cylindrical shell 1; And to be located in cylindrical shell and the light that light source 5 is launched successively through collimating lens 6, spectroscope 7 and luminous flux compensation mirror 8; And being fixedly connected with cylindrical shell 1 one end away from light source 5, and the round platform prism 9 that the light through luminous flux compensation mirror 8 is injected; And to be located in cylindrical shell and to be positioned at spectroscope 7 side, and accept successively through cylindrical mirror 10 that round platform prism 9 transmission, luminous flux compensation mirror 8 transmission and spectroscope 7 reflection ray are injected; And to be located in cylindrical shell and to be positioned at the side of cylindrical mirror 10 away from spectroscope 7, and the photodetector 11 through cylindrical mirror 10 light can be received, pressure transducer 2 measuring junction is arranged on the cylindrical shell of area detection optical measuring head 1.
With reference to Fig. 2, wherein round platform prism 9 designs based on total internal reflection principle, round platform prism 9 is about centrosymmetry, its cone angle is 60 °, its basal surface diameter D2 is 4.4:10.4 with the length ratio of top surface diameter D1, with reference to Fig. 3, when round platform prism 9 does not contact with cornea 19, due to total internal reflection, the luminous flux that the photodetector 11 of area detection optical measuring head 1 detects will equal the whole luminous fluxes entering round platform prism 9; When round platform prism 9 contacts with cornea 19, in the part of cornea applanation, due to the transmission of light, major part light will enter eyeball, to reflected light do not had or only have a very weak part like this, after luminous flux compensation mirror 8 with spectroscope 7, be projected to photodetector 11 by cylindrical mirror 10 again, take this photocurrent variations and can demarcate flat angle membrane area size.
In area detection optical measuring head 1 work process, light source 5 launch light after collimating lens 6 successively through spectroscope 7 and luminous flux compensation mirror 8, inject round platform prism 9, round platform prism 9 hangs and is fixed on cylinder inboard wall, vertically enter the light of round platform prism 9 behind its side and bottom surface internal reflection, directive luminous flux compensation mirror 8, then reflect through spectroscope 7, horizontal sheaf cylindrical mirror 10; Cylindrical mirror 10 exports ray cast in photodetector 11; The cornea applanation area change signal that photodetector 11 on area detection optic probe 1 can be detected is delivered to signal pickup assembly 17.
Wherein signal pickup assembly 17 is data collecting card, signal processing and control device 18 are computer, displacement transducer 3, pressure transducer 2 and photodetector 11 output signal sends into data collecting card input port respectively by data wire, and data collecting card output port is connected with computer; Micro-step motor 4 is controlled by the computer 18 that signal control and process software are housed.
A kind of its biological mechanical property planishing type measuring device that the present invention also proposes carries out the method measured, and comprises the steps:
Enabling signal process and control device 18 control micro-step motor 4 and work, and micro-step motor 4 drives guide rod 15 to move, and guide rod 15 drives displacement transducer 3 and pressure transducer 2 to move, and pressure transducer 2 drives area detection optic probe 1 to move; The area of signal A of detection is gathered by signal pickup assembly 17 by displacement transducer 3 by the displacement signal W of perception, pressure transducer 2 by the pressure signal F of detection and area detection optical measuring head 1, then the signal of Real-time Collection feeding signal processing and control device 18 process by signal pickup assembly 17, signal processing and control device 18 real-time synchronization obtain cornea and are out of shape and flatten displacement Wi (i=1,2, ..n), cornea distortion flattening pressure Fi (i=1,2, ..n), cornea distortion applanation area Ai (i=1,2 ..n).
In a specific embodiment, with reference to Fig. 6, above-mentioned its biological mechanical property planishing type measuring device carries out the method measured, and comprises the steps:
S1, adjustment area detection optical measuring head 1 position, make its round platform prism 9 center aim at corneal vertex;
S2, corneal hysteresis performance, cornea stiffness measurement: control micro-step motor 4 by signal processing and control device 18 and work, and then drive the round platform prism 9 of area detection optic probe 1 to move with corneal applying step loads, first carry out three CYCLIC LOADING-unloadings, complete presetting; The cornea obtained according to signal processing in the 4th CYCLIC LOADING-uninstall process and control device 18 is out of shape flattening pressure Fi and cornea and is out of shape and flattens displacement Wi, and drafting Fi-Wi curve, completes corneal hysteresis Performance Detection; Linear fit Fi-Wi curve, obtains cornea stiffness parameters;
S3, cornea relaxation property detect: control micro-step motor (4) by signal processing and control device 18 and work, and then drive the round platform prism 9 of area detection optic probe 1 to flatten cornea, when cornea distortion flattens displacement Wi=0.15mm, signal processing and control device 18 control micro-step motor 4 and quit work; Within the after this t=0-1800s time, the cornea utilizing signal processing and control device 18 real-time synchronization to obtain is out of shape flattening pressure Fi (i=1,2 ..n) and draws and show Fi-t curve, completes cornea relaxation property and measures;
S4, cornea croop property detect: control micro-step motor 4 by signal processing and control device 18 and work, and then drive the round platform prism 9 of area detection optic probe 1 to flatten cornea, as cornea distortion flattening pressure Fi=0.03N, signal processing and control device 18 control micro-step motor 4 and quit work; Within the after this t=0-1800s time, the cornea utilizing signal processing and control device 18 real-time synchronization to obtain is out of shape and flattens displacement Wi (i=1,2 ..n) and draw and show Wi-t curve, completes cornea croop property and measures;
S5, intraocular pressure detect: control micro-step motor 4 by signal processing and control device 18 and work, and then drive the round platform prism 9 of area detection optic probe 1 to flatten cornea, cornea distortion applanation area Ai=7.35mm
2time, signal processing and control device 18 control micro-step motor 4 and quit work; The cornea utilizing signal processing and control device 18 real-time synchronization to obtain is out of shape flattening pressure Fi (i=1,2 ..n), cornea is out of shape applanation area Ai (i=1,2 ..n) and draws and show Fi/Ai-t curve, completes intraocular pressure Dynamic Acquisition; Utilize Ai=7.35mm
2time corresponding Fi numerical value, according to Fi/Ai calculate survey eyeball physiological environment intraocular pressure value.
It should be noted that; in the present invention; the order of S2, S3, S4, S5 tetra-steps is not limited; can adjust according to the order of the convenience of arrangement of time to above-mentioned four steps; those skilled in the art are not paying on the basis of creative work; to the technical scheme that the arrangement adjustment of above-mentioned four steps obtains, all should within protection scope of the present invention.
Above-mentioned embodiment can achieve the complete test of integration and the assessment of corneal hysteresis performance, cornea rigidity, cornea relaxation property, cornea croop property and intraocular pressure to physiological environment cornea, for clinicist and research worker understand the deformation mechanism of cornea under physiology intraocular pressure environment, build corneal material this enough equation and the plan of myopia cornea refractive surgery and postoperative evaluation provide reference.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (7)
1. an its biological mechanical property planishing type measuring device, it is characterized in that, comprise supporting construction (12), guide rod (15), micro-step motor (4), pressure transducer (2), displacement transducer (3), area detection optic probe (1), signal pickup assembly (17) and signal processing and control device (18); One end of micro-step motor (4) and the stiff end of displacement transducer (3) are arranged in supporting construction (12) respectively successively, and the measuring junction of the other end of micro-step motor and displacement transducer (3) is arranged on guide rod (15) respectively successively; The stiff end of pressure transducer (2) is arranged on guide rod (15), measuring junction is arranged on area detection optic probe (1), micro-step motor (4) drives guide rod (15) mobile, guide rod (15) drives displacement transducer (3) and pressure transducer (2) to move, and pressure transducer (2) drives area detection optic probe (1) mobile; Displacement transducer (3) can change in displacement signal between perception its stiff end and measuring junction, pressure transducer (2) can the pressure change signal of its stiff end of perception and measuring junction, area detection optic probe (1) detectable angle membrane area variable signal;
The signal output part of area detection optic probe (1), pressure transducer (2) and displacement transducer (3) is connected with the signal input part communication of signal pickup assembly (17) respectively, and the change in displacement signal of perception is sent to signal pickup assembly (17) by the pressure change signal of perception and displacement transducer (3) by the cornea area change signal of detection, pressure transducer (2) by area detection optic probe (1); The signal output part of signal pickup assembly (17) is connected with the signal input part communication of signal processing with control device (18), and signal processing and control device (18) obtain change in displacement signal, pressure change signal and cornea area change signal by signal pickup assembly (17); Signal processing is connected with the signal input part communication of micro-step motor (4) with the signal output part of control device (18), and signal processing and control device (18) control micro-step motor (4) according to change in displacement signal, pressure change signal and cornea area change signal and work.
2. its biological mechanical property planishing type measuring device according to claim 1, it is characterized in that, area detection optical measuring head (1) comprises cylindrical shell, and is fixedly connected on the light source (5) of cylindrical shell (1) interior one end; And to be located in cylindrical shell and the light that light source (5) is launched successively through collimating lens (6), spectroscope (7) and luminous flux compensation mirror (8); And being fixedly connected with cylindrical shell (1) one end away from light source (5), and the round platform prism (9) that the light through luminous flux compensation mirror (8) is injected; And to be located in cylindrical shell and to be positioned at spectroscope (7) side, and accept successively through cylindrical mirror (10) that round platform prism (9) transmission, (8) transmission of luminous flux compensation mirror and spectroscope (7) reflection ray are injected; And to be located in cylindrical shell and to be positioned at the side of cylindrical mirror (10) away from spectroscope (7), and the photodetector (11) through cylindrical mirror (10) light can be received; The cornea area change signal that photodetector (11) on area detection optic probe (1) can be detected is delivered to signal pickup assembly (17).
3. its biological mechanical property planishing type measuring device according to claim 2, it is characterized in that, pressure transducer (2) is arranged on the cylindrical shell of area detection optical measuring head (1).
4. its biological mechanical property planishing type measuring device according to claim 1, it is characterized in that, micro-step motor (4) comprises motor lead screw (14), and micro-step motor (4) is arranged on guide rod (15) by motor lead screw (14).
5. its biological mechanical property planishing type measuring device according to claim 1, it is characterized in that, supporting construction (12) is provided with crossbeam (13), and the stiff end of micro-step motor (4) and displacement transducer (3) is arranged on the crossbeam (13) of supporting construction (12) respectively successively.
6. its biological mechanical property planishing type measuring device according to any one of claim 1-5 carries out the method measured, and it is characterized in that, comprises the steps:
Enabling signal process and control device (18) control micro-step motor (4) and work, micro-step motor (4) drives guide rod (15) mobile, guide rod (15) drives displacement transducer (3) and pressure transducer (2) to move, and pressure transducer (2) drives area detection optic probe (1) mobile, displacement transducer (3) is by the displacement signal W of perception, the area of signal A of detection is gathered by signal pickup assembly (17) by pressure transducer (2) by the pressure signal F of detection and area detection optical measuring head (1), then the signal of Real-time Collection feeding signal processing and control device (18) process by signal pickup assembly (17), signal processing and control device (18) real-time synchronization obtain cornea and are out of shape and flatten displacement Wi (i=1, 2, ..n), cornea distortion flattening pressure Fi (i=1, 2, ..n), cornea distortion applanation area Ai (i=1, 2, ..n).
7. its biological mechanical property planishing type measuring device according to claim 6 carries out the method measured, it is characterized in that, comprises the steps:
S1, adjustment area detection optical measuring head (1) position, make its round platform prism (9) center aim at corneal vertex;
S2, corneal hysteresis performance, cornea stiffness measurement: control micro-step motor (4) by signal processing and control device (18) and work, and then drive area detection optic probe (1) mobile with corneal applying step loads, first carry out N CYCLIC LOADING-unloading, complete presetting, wherein N is greater than 0 and is integer; The cornea obtained according to signal processing in the N+1 time CYCLIC LOADING-uninstall process and control device (18) is out of shape flattening pressure Fi and cornea and is out of shape and flattens displacement Wi, and drafting Fi-Wi curve, completes corneal hysteresis Performance Detection; Linear fit Fi-Wi curve, obtains cornea stiffness parameters;
S3, cornea relaxation property detect: control micro-step motor (4) by signal processing and control device (18) and work, and then drive area detection optic probe (1) to flatten cornea, when cornea distortion flattens displacement Wi=0.1-0.2mm, signal processing and control device (18) control micro-step motor (4) and quit work; Within the after this t=0-1800s time, the cornea utilizing signal processing and control device (18) real-time synchronization to obtain is out of shape flattening pressure Fi (i=1,2 ..n) and draws and show Fi-t curve, completes cornea relaxation property and measures;
S4, cornea croop property detect: control micro-step motor (4) by signal processing and control device (18) and work, and then drive area detection optic probe (1) to flatten cornea, as cornea distortion flattening pressure Fi=0.02-0.05N, signal processing and control device (18) control micro-step motor (4) and quit work; Within the after this t=0-1800s time, the cornea utilizing signal processing and control device (18) real-time synchronization to obtain is out of shape and flattens displacement Wi (i=1,2 ..n) and draw and show Wi-t curve, completes cornea croop property and measures;
S5, intraocular pressure detect: control micro-step motor (4) by signal processing and control device (18) and work, and then drive area detection optic probe (1) to flatten cornea, cornea distortion applanation area Ai=6-8mm
2time, signal processing and control device (18) control micro-step motor (4) and quit work; The cornea utilizing signal processing and control device (18) real-time synchronization to obtain is out of shape flattening pressure Fi (i=1,2 ..n), cornea distortion applanation area Ai (i=1,2, ..n) draw display Fi/Ai-t curve, complete intraocular pressure Dynamic Acquisition; Utilize Ai=6-8mm
2time corresponding Fi numerical value, according to Fi/Ai calculate survey eyeball physiological environment intraocular pressure value.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105167805A (en) * | 2015-08-19 | 2015-12-23 | 深圳市亿领科技有限公司 | Cornea elasticity measurement method and cornea elasticity measurement device |
| CN105342551A (en) * | 2015-10-23 | 2016-02-24 | 济南三维医疗器械有限公司 | Instrument for detecting cornea biomechanics and application method of instrument |
| CN106840890A (en) * | 2017-01-09 | 2017-06-13 | 四川大学 | A kind of cornea three-dimensional whole field stress strain response measuring system and its measuring method |
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| ES2662697A1 (en) * | 2016-10-03 | 2018-04-09 | Maria IGLESIAS ALVAREZ | APPLICATION TONOMETER (Machine-translation by Google Translate, not legally binding) |
| CN106840890A (en) * | 2017-01-09 | 2017-06-13 | 四川大学 | A kind of cornea three-dimensional whole field stress strain response measuring system and its measuring method |
| CN109602498A (en) * | 2018-12-06 | 2019-04-12 | 哈尔滨工业大学 | A kind of Ophthalimic microsurgery auxiliary robot scaling method |
| CN109602498B (en) * | 2018-12-06 | 2022-03-01 | 哈尔滨工业大学 | Ophthalmic micro-surgery auxiliary robot calibration mechanism |
| CN110974156A (en) * | 2019-12-28 | 2020-04-10 | 山东第一医科大学(山东省医学科学院) | Intraocular pressure sensor |
| WO2023092916A1 (en) * | 2021-11-26 | 2023-06-01 | 华南理工大学 | Method for determining applanation of pressing head of tonometer on basis of force applied to pressing head |
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