CN104794341A - Traditional Chinese medicine and western medicine combined medication contraindication early-warning system - Google Patents
Traditional Chinese medicine and western medicine combined medication contraindication early-warning system Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine and western medicine combined medication contraindication early-warning system. A method includes information inquiry about single traditional Chinese medicine and western medicine and contraindication inquiry about mutual relations between multiple traditional Chinese medicine and western medicine. Data sources mainly include ancient literature of eighteen incompatible herb and mutual antagonism nineteen herb medicine pairs, experimental data, Chinese patent medicine data, modern literature and molecule data. According to collection of the modern literature, through an HTTP request, literature containing related bad contraindication keywords on web pages is captured, and an expert checks collection data so that useful modern literature data can be stored into a local database in the same format and real-time updating of the data inside the database can be ensured.
Description
Technical field:
The present invention relates generally to the interaction relationship of traditional Chinese medicine, Western medicine drug combination, provides a kind of traditional Chinese and western medicine drug combination to avoid the realization of early warning system.Single mainly for data source, the shortcoming of drug combination case deficiency, propose enrichment multi-data source, for amateur medical personnel, the interaction between single or multi-flavor medicine is inquired about, or the taboo early warning system of inquiry to medicine, prescription details.
Background technology:
Traditional Chinese medicine has quite long history, and experienced by transition and the development of different times, Chinese medical culture has become the cultural characteristic of China, and the document that record traditional Chinese medicine is correlated with simultaneously is then constantly passed on by later age as medical civilized accumulation and precipitation.But because the impact of the many factors such as dynasty, geographic position, the form with contemporary period recorded by the document of different times.Simultaneously along with the application of traditional Chinese medicine in modern clinic and the introduction of Western medicine, medication information progressively presents development in pluralism form.
Along with the development of Internet technology, the work of medical aspect is also progressively by the pattern of the medical management platform on labor management switch-back.In view of the Data Source of traditional Chinese medicine has ancient literature, modern clinic, modern experimental, patent, the various ways such as Chinese patent drug, ensure that the integrality of data source becomes one of Major Difficulties of current traditional Chinese medicine management system.
Traditional Chinese medicine is mainly particular about health over the course for the treatment of and is in harmonious proportion, and therefore the course for the treatment of is relatively long, and Western medicine is then on the contrary, so the two frequent conbined usage in clinical utilization, thus plays complementary effect.So introducing Western medicine based on the basis studied traditional Chinese medicine drug combination, completing probing into of the interaction relationship of Chinese and Western medicine drug combination and can more comprehensively go to analyze the reaction effect between medicine and taboo reason.
Summary of the invention:
The technical matters that the present invention mainly solves is to provide a kind of traditional Chinese medicine drug combination taboo early warning system, mainly for TCM data source variation and how to set up an inquiry towards the Combined effects relation of layman with Western medicine in conjunction with problem and avoid early warning system, thus meet domestic consumer to the interactional query demand of Chinese and Western medicine drug combination, and provide corresponding medicine use-case in corresponding taboo reason and multiple data sources.
Technical scheme of the present invention is: a kind of traditional Chinese and western medicine drug combination taboo early warning system, and two parts are inquired about in the taboo of the information inquiry and Chinese and Western medicine multi-flavor drug interactions that comprise Chinese and Western medicine single medicine; Wherein the data source of information inquiry and taboo inquiry is mainly containing the ancient literature that " eighteen incompatibilities nineteen counteraction " medicine is right, experimental data, pcm data, Modern Literature, the multiple data sources such as molecular data;
The collection of Modern Literature is captured the document containing relevant bad taboo key word on webpage by HTTP request, by expert, image data is audited, useful Modern Literature data are deposited in the local database with same form, to guarantee the real-time update of data in database;
The taboo of described Chinese and Western medicine multi-flavor drug interactions judges to realize mainly through two kinds of methods.One is to the medicine containing " eighteen incompatibilities nineteen counteraction " and bad reaction to retrieving, if containing then directly carrying out early warning; Two is by analyzing at molecular layer the medicine that bad reaction occurs, and sets up the interaction relationship between the different kinds of molecules composition producing bad reaction effect; Molecular layer judges whether combined Chinese & western medicine can produce bad reaction, thus according to corresponding analysis result, provides data to prove and early warning, meet the demand of the safe medication of user to domestic consumer;
Described analyzes multi-flavor drug interaction from molecular layer, adopt the method setting up network model, the network model set up respectively between network model between drug effect and molecular action forms medicine layer and molecular layer, then the corresponding relation of medicine layer and molecular layer is set up, the filtration carrying out medicine layer by the multi-medicament inputted user enters the analysis of drug molecule composition, and then drug molecule composition is entered molecular layer analysis as input data, if produce bad reaction, provide taboo prompting.
Beneficial effect of the present invention: for problems such as the data source unicity of traditional Chinese medicine management system and limitation, propose a kind of accurately, drug combination taboo early warning system that is general, the combination of Chinese tradiational and Western medicine, major advantage is:
(1) accuracy is high: for the singularity of traditional Chinese medicine record, in order to provide taboo reason more comprehensively to prove, adopts multiple data sources form to carry out data acquisition and storage.Comprising ancient literature, Modern Literature, Chinese patent drug, experimental data, patent data, molecular data etc., the variation of data source improves the accuracy rate of taboo judgement.
(2) versatility is good: usual medical related system towards user be all specialty or the student with medical knowledge, and user of the present invention is not only these colonies, also can meet the demand that domestic consumer is inquired about drug interaction simultaneously, there is better generalization and versatility.
(3) real-time is good: for the continuous renewal problem of the clinical data of herb-drug interactions, and a kind of spiders technology is taked in this invention, can be concurrent while system cloud gray model capture dynamically online pertinent literature on backstage.
(4) extensibility is high: the present invention not only only considers the interaction between medicine when judging whether there is bad reaction between multi-flavor medicine, simultaneously more deeply carry out analyzing the interaction relationship between medicine from molecular layer, thus user not only can inquire about the taboo situation between kinds of traditional Chinese medicines, the operative condition between multiple combination such as also can to inquire about between Chinese medicine and Western medicine, between Western medicine and Western medicine, between Chinese medicine and composition, between Western medicine and composition, between composition and composition.
Accompanying drawing illustrates:
Fig. 1 is present system prototype structure figure;
Fig. 2 is the E-R figure of database design of the present invention;
Fig. 3 is present system logical flow chart;
Embodiment:
In order to clearly introduce this invention, next in conjunction with system prototype structural drawing of the present invention, the module of every layer will be explained in detail.
Fig. 1 is the structural drawing of present system prototype, is wherein mainly divided into three levels:
(1) basic data module, this module mainly comprises the integration of multiple data source, and different data sources has different authority, can formulate different weights according to corresponding authority.
A. ancient literature, these data mainly refer to containing the record in the right Ancient books of " eighteen incompatibilities, nineteen counteraction " medicine or document.As, Bencao jizhu, author is Tao Hongjing, the Northern and Southern Dynasties
.nan Liang, mica reflux water.
B. Chinese patent drug, these data refer to and start Reusability in clinical, obtain one-tenth side's Chinese medicine preparation of state approval.As fallen turbid vigorous and graceful particle, its formulation ingredients is hawthorn, radish seed, the dried immature fruit of citron orange, the bark of official magnolia, chrysanthemum, Fructus Hordei Germinatus, dried orange peel, fructus cannabis, green tea, Medicated Leaven, dextrin, aspartame.
C. Modern Literature, these data refer to some documents or paper that modern clinic or modern scholar deliver, therefrom obtain drug interaction relation, main acquiring way is by using the reptile analytical technology based on http agreement to obtain the document relevant with traditional Chinese medicine, by whether meeting demand to literature content analysis judgment, then the document or paper that meet demand are captured with cannonical format.
D. experimental data, these data refer to the medicine by making the experimental subjectss such as small white mouse take various dose, the physiological change of observation experiment object, and are recorded.
E. patent, these data refer to the patented claim relevant with drug interaction.
F. bad reaction is noticed, and the bad reaction notification data that these data refer to " state food pharmaceuticals administration general bureau " issues, this partial data can swash from webpage and take off.
G. molecular data, these data mainly refer to the chemical composition of medicine.
(2) evaluation module:
A. based on the toxicity assessment system of drug interaction, by investigating the interaction between the Chinese traditional medicine of different pieces of information source, correlation analysis being carried out to acute toxicity data, setting up the method to inquiry medicine express-analysis screening.
B. based on the assessment models of molecular layer, for the impact of molecule on cell, histoorgan, evaluate toxicity feature and the toxic degree of drug interaction, build the rapid screening method of the compatibility of drugs relation based on molecule.
(3) reporting modules:
On the basis of evaluation module, toxicity test is carried out to the input data of user, then added up and screening by the positive example in different pieces of information source and counter-example, with reference to the authority of each data source, obtain a toxic grade, can severe toxicity be divided into, poison, available three grades, then using the warning lamp of different colours as final assessment result, provide the ratio and source that come from positive example and counter-example in different pieces of information source with the judgement of assisting users to the security of drug combination simultaneously.
E-R figure see Fig. 2 is database design:
Containing 7 tables of data in whole database, store the data of the drug interaction of separate sources respectively, wherein ancient literature, Modern Literature, experimental data, patent, bad reaction is advertised as the providing source of counter-example, primary format be containing two interactional medicines to other details such as relevant source; Modern Literature, Chinese patent drug is the main providing source of positive example, and wherein the data layout of Chinese patent drug is prescription name and recipe drug composition; Molecular data form is molecule name and affiliated medicine and other details of being correlated with.
Be present system logical flow chart see Fig. 3:
(1) single medicine contraindication:
User needs the single medicine of inquiry in browser end input, data query is submitted to controller with sheet format by system, and available Servlet technology carries out the control of business, then by the acute toxicity analysis to corresponding entity class, evaluate taboo grade, give user feedback with report form.
(2) medicine is to taboo
User is about to a herbal medicine of the medicine centering of inquiry in browser end input, data query is submitted to backstage Servlet with sheet format and is carried out work flow by system equally, then by the assessment of two kinds of modes in evaluation module, the medicine list of generation and this medicine generation bad reaction, and sort with different toxic grade.User can check for details by any one medicine in selective listing, when user has the demand of checking details, the positive counter-example ratio situation of the assessment result that evaluation module provides by system and all data sources shows user with report form, selects medicine with assist users to safety.
(3) multi-flavor medicine contraindication
A. multi-flavor medicine contraindication inquiry, namely user can directly input multi-flavor medicine, system is submitted to sheet format, on backstage, input data are assessed, medicine containing bad reaction in multi-flavor medicine is provided with tabular form, successively decrease with toxic grade simultaneously and sequentially show, user can check relevant details (reference drug is to taboo) equally.
B. prescription and prescription taboo inquiry, user can input different prescription when inquiring about and inquire about, and each prescription is made up of multiple medicine, so can with reference to the method for multi-flavor medicine contraindication in evaluation module.
C. the inquiry of molecule and multi-flavor medicine, user can browser end input need inquiry molecule and multi-flavor medicine, then submit to sheet format, when background process, multi-flavor medicine is carried out to the assessment of the toxicity assessment system based on drug interaction, constituent analysis is carried out to medicine simultaneously, then to decompose composition and be entered as point assessment carrying out the assessment models based on molecular layer, finally assessment result is fed back to user with report form, provide corresponding taboo grade and relevant direct proportion information.
D. Western medicine and drug contraindication inquiry, user can the Western medicine of browser end input inquiry and Chinese medicine, and then system is submitted to sheet format, and backstage is to submission data analysis, first, kinds of traditional Chinese medicines is carried out the assessment of the toxicity assessment system based on drug interaction; Then, Chinese medicine and Western medicine are decomposed in units of molecule, then obtain the molecular data belonging to different Chinese and Western medicine, these molecules are carried out the assessment of the assessment models based on molecular layer.Finally, two assessment results are combined into report, carry out arrangement with toxic grade and feed back to user.
As aconitum contains aconitine, mesaconitine, Hypaconitine, multiple chemical composition such as septentrionaline, then have between these composition and rhizome of Chinese monkshoods and connect frontier juncture system, and the chemical composition of the bletilla striata has 3, 5-dimethoxy bibenzyl, 3, 3, 5 '-trimethoxy bibenzyl, 5-hydroxyl-4-(to hydroxybenzyl)-3 ', 3-dimethoxy bibenzyl etc., wherein the rhizome of Chinese monkshood and the bletilla striata belong to eighteen incompatibilities medicine pair, its map network model structure is positioned at medicine layer, and the chemical composition that it comprises is positioned at molecular layer, as input medicine A and medicine B, judge whether it belongs to the taboo medicine pair of medicine layer, if do not belonged to, check the chemical composition of medicine A and medicine B, if medicine A contains the mesaconitine in rhizome of Chinese monkshood chemical composition, medicine B contains in bletilla striata chemical composition 3, 3, 5 '-trimethoxy bibenzyl, then think and may produce toxic and side effect between medicine A and medicine B, thus provide warning and early warning reason.
In sum, the invention provides a multi-data source, the drug combination taboo system of Integrated TCM, solve the demand for security of domestic consumer's drug combination, simultaneously, from by the toxicity assessment system based on drug interaction with combine based on the assessment models of molecular layer, improve accuracy and the expansion of system.
Claims (4)
1. a traditional Chinese and western medicine drug combination taboo early warning system, is characterized in that two parts are inquired about in the taboo of the information inquiry and Chinese and Western medicine multi-flavor drug interactions comprising Chinese and Western medicine single medicine; Wherein data source is mainly containing the ancient literature that " eighteen incompatibilities nineteen counteraction " medicine is right, experimental data, pcm data, Modern Literature, the multiple data sources such as molecular data;
The collection of Modern Literature is captured the document containing relevant bad taboo key word on webpage by HTTP request, by expert, image data is audited, useful Modern Literature data are deposited in the local database with same form, to guarantee the real-time update of data in database;
The taboo of described Chinese and Western medicine multi-flavor drug interactions judges to realize mainly through two kinds of methods.One is to the medicine containing " eighteen incompatibilities nineteen counteraction " and bad reaction to retrieving, if containing then directly carrying out early warning; Two is by analyzing at molecular layer the medicine that bad reaction occurs, and sets up the interaction relationship between the different kinds of molecules composition producing bad reaction effect; Molecular layer judges whether combined Chinese & western medicine can produce bad reaction, thus according to corresponding analysis result, provides data to prove and early warning, meet the demand of the safe medication of user to domestic consumer;
Described analyzes multi-flavor drug interaction from molecular layer, adopt the method setting up network model, the network model set up respectively between network model between drug effect and molecular action forms medicine layer and molecular layer, then the corresponding relation of medicine layer and molecular layer is set up, the filtration carrying out medicine layer by the multi-medicament inputted user enters the analysis of drug molecule composition, and then drug molecule composition is entered molecular layer analysis as input data, if produce bad reaction, provide taboo prompting.
2. avoid early warning system by traditional Chinese and western medicine drug combination according to claim 1, it is characterized in that single medicine contraindication query script, user needs the single medicine of inquiry in browser end input, data query is submitted to controller with sheet format by system, the control of business is carried out by Servlet technology, then by the acute toxicity analysis to corresponding entity class, evaluate taboo grade, give user feedback with report form.
3. avoid early warning system by traditional Chinese and western medicine drug combination according to claim 1, it is characterized in that medicine is to taboo query script, user is about to a herbal medicine of the medicine centering of inquiry in browser end input, data query is submitted to backstage Servlet with sheet format and is carried out work flow by system equally, then by the assessment of two kinds of modes in evaluation module, the medicine list of generation and this medicine generation bad reaction, and sort with different toxic grade; In user's selective listing, any one medicine is checked for details, when user has the demand of checking details, the positive counter-example ratio situation of the assessment result that evaluation module provides by system and all data sources shows user with report form, selects medicine with assist users to safety.
4. avoid early warning system by traditional Chinese and western medicine drug combination according to claim 1, it is characterized in that medicine is to taboo multi-flavor medicine contraindication query script,
A. multi-flavor medicine contraindication inquiry, namely user directly inputs multi-flavor medicine, system is submitted to sheet format, on backstage, input data are assessed, medicine containing bad reaction in multi-flavor medicine is provided with tabular form, successively decrease with toxic grade simultaneously and sequentially show, user can check relevant details equally;
B. prescription and prescription taboo inquiry, user can input different prescription when inquiring about and inquire about, and each prescription is made up of multiple medicine, so with reference to the method for multi-flavor medicine contraindication in evaluation module;
C. the inquiry of molecule and multi-flavor medicine, user can browser end input need inquiry molecule and multi-flavor medicine, then submit to sheet format, when background process, multi-flavor medicine is carried out to the assessment of the toxicity assessment system based on drug interaction, constituent analysis is carried out to medicine simultaneously, then to decompose composition and be entered as point assessment carrying out the assessment models based on molecular layer, finally assessment result is fed back to user with report form, provide corresponding taboo grade and relevant direct proportion information;
D. Western medicine and drug contraindication inquiry, the Western medicine of user browser end input inquiry and Chinese medicine, then system is submitted to sheet format, and kinds of traditional Chinese medicines, to submission data analysis, first, is carried out the assessment of the toxicity assessment system based on drug interaction by backstage; Then, Chinese medicine and Western medicine are decomposed in units of molecule, then obtain the molecular data belonging to different Chinese and Western medicine, these molecules are carried out the assessment of the assessment models based on molecular layer; Finally, two assessment results are combined into report, carry out arrangement with toxic grade and feed back to user.
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