CN104744333A - 一种奈莫必利的生产方法 - Google Patents

一种奈莫必利的生产方法 Download PDF

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Publication number
CN104744333A
CN104744333A CN201310730951.XA CN201310730951A CN104744333A CN 104744333 A CN104744333 A CN 104744333A CN 201310730951 A CN201310730951 A CN 201310730951A CN 104744333 A CN104744333 A CN 104744333A
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CN
China
Prior art keywords
nemonapride
production method
methyl
methylamino
pyrrolidone
Prior art date
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Pending
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CN201310730951.XA
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English (en)
Inventor
张云
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Individual
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Individual
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Priority to CN201310730951.XA priority Critical patent/CN104744333A/zh
Publication of CN104744333A publication Critical patent/CN104744333A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种奈莫必利的生产方法，具体步骤如下：2-甲基-N-(苯基甲基)-3-吡咯烷酮先和盐酸羟胺反应后，再还原，在3位引入氨基，再和5-氯-2-甲氧基-4-(甲基氨基)苯甲酸反应，即得到奈莫必利。所述的一种奈莫必利的生产方法，其制造成本低，生产方便。

Description

一种奈莫必利的生产方法
技术领域
本发明涉及药物制备的领域，尤其是一种奈莫必利的生产方法。
背景技术
奈莫必利具有较强的抗精神病作用，能改善幻觉和妄想等症状，对脱氧麻黄碱和阿扑吗啡引起的刻板行为及运动过度行为有明显抑制，其作用相似于氟哌啶醇，强于氯丙嗪。其作用机制为选择性地抑制脑内D2-多巴胺受体，且此作用极强，而对α-肾上腺素受体与M-胆碱受体作用极弱，故而其抗胆碱作用与镇静作用弱，副作用小。由于目前生产的奈莫必利，制造成本高，生产复杂。
发明内容
本发明要解决的技术问题是：为了克服上述中存在的问题，提供了一种奈莫必利的生产方法。
本发明解决其技术问题所采用的技术方案是：一种奈莫必利的生产方法，具体步骤如下：2-甲基-N-(苯基甲基)-3-吡咯烷酮先和盐酸羟胺反应后，再还原，在3位引入氨基，再和5-氯-2-甲氧基-4-(甲基氨基)苯甲酸反应，即得到奈莫必利。
本发明的有益效果是：所述的一种奈莫必利的生产方法，其制造成本低，生产方便。
具体实施方式
现在结合本发明作进一步详细的说明。
本发明的一种奈莫必利的生产方法，具体步骤如下：2-甲基-N-(苯基甲基)-3-吡咯烷酮先和盐酸羟胺反应后，再还原，在3位引入氨基。再和5-氯-2-甲氧基-4-(甲基氨基)苯甲酸反应，即得到奈莫必利，该药是选择性的阻滞D2-多巴胺受体，抑制中枢多巴胺神经系统，用于精神分裂症的治疗。
以上述依据本发明的理想实施例为启示，通过上述的说明内容，相关工作人员完全可以在不偏离本项发明技术思想的范围内，进行多样的变更以及修改。本项发明的技术性范围并不局限于说明书上的内容，必须要根据权利要求范围来确定其技术性范围。

Claims (1)

1.一种奈莫必利的生产方法，其特征是具体步骤如下：2-甲基-N-(苯基甲基)-3-吡咯烷酮先和盐酸羟胺反应后，再还原，在3位引入氨基，再和5-氯-2-甲氧基-4-(甲基氨基)苯甲酸反应，即得到奈莫必利。
CN201310730951.XA 2013-12-26 2013-12-26 一种奈莫必利的生产方法 Pending CN104744333A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310730951.XA CN104744333A (zh) 2013-12-26 2013-12-26 一种奈莫必利的生产方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310730951.XA CN104744333A (zh) 2013-12-26 2013-12-26 一种奈莫必利的生产方法

Publications (1)

Publication Number Publication Date
CN104744333A true CN104744333A (zh) 2015-07-01

Family

ID=53584686

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310730951.XA Pending CN104744333A (zh) 2013-12-26 2013-12-26 一种奈莫必利的生产方法

Country Status (1)

Country Link
CN (1) CN104744333A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023130117A1 (en) * 2022-01-03 2023-07-06 Engrail Therapeutics, Inc. Deuterated organic compounds and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023130117A1 (en) * 2022-01-03 2023-07-06 Engrail Therapeutics, Inc. Deuterated organic compounds and uses thereof

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PB01 Publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150701

WD01 Invention patent application deemed withdrawn after publication