CN104725235A - Preparation method of methyl paraben - Google Patents
Preparation method of methyl paraben Download PDFInfo
- Publication number
- CN104725235A CN104725235A CN201310718495.7A CN201310718495A CN104725235A CN 104725235 A CN104725235 A CN 104725235A CN 201310718495 A CN201310718495 A CN 201310718495A CN 104725235 A CN104725235 A CN 104725235A
- Authority
- CN
- China
- Prior art keywords
- preparation
- aluminum sulfate
- methyl paraben
- tegosept
- sulfate hydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a preparation method of methyl paraben. The preparation method comprises the following steps: 1) adding methanol and p-hydroxybenzoic acid in the molar ratio of 35: 1, as well as aluminum sulfate hydrate into a high-pressure reaction kettle, stirring and heating to 130 DEG C and reacting for 3h; and 2) adding water after the reaction, heating to evaporate out unreacted methanol, dropping a sodium hydroxide solution into remaining liquid, cooling, precipitating solids, performing suction filtration, washing and drying to obtain white powder-like methyl paraben. According to the preparation method of methyl paraben provided by the invention, aluminum sulfate hydrate is used as a catalyst, and aluminum sulfate hydrate has high catalytic activity, simple operation, no equipment corrosion, low price, no toxicity and no environmental pollution, thereby being a green catalyst.
Description
Technical field
The present invention relates to a kind of preparation method of sanitas, be specifically related to a kind of preparation method of Tegosept M.
Background technology
Nipagin esters is also called para hydroxybenzene potassium acid esters, is the series of anticorrosion agent that purposes is the widest in the world, consumption is maximum, applying frequency is the highest at present.The advantages such as it has efficiently, low toxicity, spectrum, easily compatibility, be widely used in the aspects such as daily use chemicals, medicine, food, feed and various industrial antisepsis, wherein Tegosept M is strong fungicide.The synthesis of Tegosept M adopts P-hydroxybenzoic acid and methyl alcohol directly to prepare under vitriol oil effect usually, but sulfuric acid has serious corrodibility, easily side reaction and contaminate environment occurs.
Summary of the invention
The object of the invention is to, provide a kind of preparation method of Tegosept M, be catalyzer with hydrazine aluminum sulfate, catalytic activity is high, simple to operate, corrosion-free to equipment, and cheap, nontoxic, environmentally safe, is a kind of green catalyst.
The preparation method of described Tegosept M, comprises the following steps:
One, in autoclave, add methyl alcohol and P-hydroxybenzoic acid that mol ratio is 35:1, hydrazine aluminum sulfate, is heated with stirring to 130 DEG C, reaction 3h;
Two, react complete, add water, heating steams unreacted methyl alcohol, drips sodium hydroxide solution in remaining liquid, and cooling separates out solid, suction filtration, washing, dry, obtains white powder Tegosept M.
The preparation method of Tegosept M provided by the invention, its beneficial effect is, be catalyzer with hydrazine aluminum sulfate, catalytic activity is high, simple to operate, corrosion-free to equipment, and cheap, nontoxic, environmentally safe, is a kind of green catalyst.
Embodiment
Below in conjunction with an embodiment, the preparation method of Tegosept M provided by the invention is described in detail.
Embodiment
One, in autoclave, add methyl alcohol and P-hydroxybenzoic acid that mol ratio is 35:1, hydrazine aluminum sulfate, is heated with stirring to 130 DEG C, reaction 3h;
Two, react complete, add water, heating steams unreacted methyl alcohol, drips sodium hydroxide solution in remaining liquid, and cooling separates out solid, suction filtration, washing, dry, obtains white powder Tegosept M.
Claims (1)
1. a preparation method for Tegosept M, is characterized in that: it comprises the following steps:
One, in autoclave, add methyl alcohol and P-hydroxybenzoic acid that mol ratio is 35:1, hydrazine aluminum sulfate, is heated with stirring to 130 DEG C, reaction 3h;
Two, react complete, add water, heating steams unreacted methyl alcohol, drips sodium hydroxide solution in remaining liquid, and cooling separates out solid, suction filtration, washing, dry, obtains white powder Tegosept M.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310718495.7A CN104725235A (en) | 2013-12-24 | 2013-12-24 | Preparation method of methyl paraben |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310718495.7A CN104725235A (en) | 2013-12-24 | 2013-12-24 | Preparation method of methyl paraben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104725235A true CN104725235A (en) | 2015-06-24 |
Family
ID=53449719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310718495.7A Pending CN104725235A (en) | 2013-12-24 | 2013-12-24 | Preparation method of methyl paraben |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104725235A (en) |
-
2013
- 2013-12-24 CN CN201310718495.7A patent/CN104725235A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104448075B (en) | For the method preparing heat stability Kynoar | |
| RU2013120972A (en) | MAGNESIUM HYDROXIDE WITH A HIGH RELATIONSHIP OF CRYSTAL SIZES | |
| CN104451642A (en) | Surface treatment process for radiator shell metal stamping piece | |
| CN103739803B (en) | The synthetic method of imino-methyl-etherified aminoresin | |
| NZ601040A (en) | Method of producing acrylic and methacrylic acid | |
| CN102408396A (en) | Method for preparing versatate glycidyl | |
| CN102617374B (en) | Method for preparing betaine hydrochloride | |
| CN104725235A (en) | Preparation method of methyl paraben | |
| CN102267911A (en) | Synthesis method of methyl salicylate | |
| CN103752339A (en) | Aluminum-doped mesoporous molecular sieve loaded phosphotungstic heteropoly acid catalyst, preparation thereof and application thereof to benzoic acid synthesis | |
| CN105366697A (en) | Preparation method of high-purity magnesium hydroxide | |
| CN105883895A (en) | Preparation method of copper iodide | |
| CN104741144A (en) | Preparation method of catalyst chitosan sulfate used for ethylparaben synthesis | |
| WO2009042091A3 (en) | Process for making ethers from alkoxide anions or precursors of alkoxide anions | |
| CN103880663A (en) | Aspirin preparation method | |
| CN104744259A (en) | Method for synthesizing ethylparaben by catalysis of chitosan sulfate | |
| CN103130721B (en) | Ornidazole synthetic method | |
| CN106893621A (en) | A kind of method that utilization cashew nut processing by-product cashew nut shell oil prepares antirust agent | |
| CN104725232A (en) | Preparation method of butyl paraben | |
| CN106977428B (en) | Improve the method for preparing lauryl sodium sulfate | |
| CN103694284B (en) | A kind of preparation technology of isopropyl-β-D-thiogalactoside(IPTG) | |
| CN104445303A (en) | Preparation method of magnesium hydrate | |
| CN103694285B (en) | A kind of preparation method of isopropyl-β-D-thiogalactoside(IPTG) | |
| CN202715270U (en) | Hydrolysis equipment in production of Qingkailing compound tablets | |
| CN103588630B (en) | Environmental-protection type copper stearate synthesis method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150624 |