CN104724891B - A kind of processing method of oxytetracycline crystallization mother liquor waste water - Google Patents
A kind of processing method of oxytetracycline crystallization mother liquor waste water Download PDFInfo
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- CN104724891B CN104724891B CN201510138634.8A CN201510138634A CN104724891B CN 104724891 B CN104724891 B CN 104724891B CN 201510138634 A CN201510138634 A CN 201510138634A CN 104724891 B CN104724891 B CN 104724891B
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- oxytetracycline
- mother liquor
- crystallization mother
- film
- terramycin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W10/00—Technologies for wastewater treatment
- Y02W10/30—Wastewater or sewage treatment systems using renewable energies
- Y02W10/37—Wastewater or sewage treatment systems using renewable energies using solar energy
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- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Removal Of Specific Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The processing method of the present invention a kind of oxytetracycline crystallization mother liquor waste water, step including an oxytetracycline crystallization mother liquor pretreatment, acid solution is added in oxytetracycline crystallization mother liquor, the pH value of oxytetracycline crystallization mother liquor is regulated to PH2 3, it is simultaneously introduced polyacrylamide so that polyacrylamide concentration in oxytetracycline crystallization mother liquor is 10 50ppm；One uses the step that organic film separates, and the molecular cut off of organic film is between 800 2500 dalton；One step that film permeate carries out biochemical treatment, carries out anaerobic-aerobic process to permeate, aerobic after the COD of sewage system less than 100ppm；Film trapped fluid is carried out separating the step obtaining terramycin crude product, film trapped fluid carries out the regulation of pH value, so that product separates out, obtains terramycin crude product by one.It is simple that the present invention processes technique, it is easy to industrialization, had both reduced the difficulty of oxytetracycline crystallization mother liquor biochemical treatment, the most recyclable terramycin product.
Description
Technical field:
The present invention relates to chemical field, particularly relate to the sewage treatment process during antibiotics production, the processing method of a kind of oxytetracycline crystallization mother liquor waste water.
Background technology:
Terramycin, for the crystalline powder of canescence to yellow, odorless, bitter, fusing point is 180 DEG C, colour-darkening in the sunlight, and in alkaline solution, destructible lost efficacy.Terramycin hydrochloride is yellow crystal, bitter, fusing point 190～194 DEG C, has hygroscopicity, but moisture and light do not affect its titer, save and not degenerate for a long time, do not lose efficacy.Hydrochloride is soluble in water, is dissolved in methyl alcohol, is slightly soluble in absolute ethyl alcohol, insoluble in chloroform and ether, unstable under acidic condition.Adding in feed, at room temperature preserve four months, titer declines 4%～9%.
Terramycin English name (Terramycin Oxytetracycline) belongs to the one of antibiotic, multiple coccus and bacillus there is antibacterial action, Richettsia and amcbiasis protozoon also there is inhibitory action, it is used for treating infection of the upper respiratory tract alimentary infection typhus etc., is mainly used in livestock and poultry medicine and feed addictive now.Terramycin is a product typically utilizing biotechnology to produce, and production technology relates to fermenting, extracts, filters, decolours, crystallizes, centrifugal and drying and other steps.
In The Oxytetracycline Production System can produce large amount of sewage, often produce 1 ton of terramycin product and can produce 200 tons of sewage, including the crystalline mother solution waste water of 100 tons；Common sewage water treatment method is the biochemical treatment mode using anaerobic-aerobic, but due to the residual of terramycin product in crystalline mother solution, causes the microorganism during anaerobic-aerobic to be difficult to grow, and causes processing procedure slowly or to be difficult to；Therefore the process technique seeking to be suitable for is very important.
Summary of the invention:
It is an object of the invention to provide the processing method of a kind of oxytetracycline crystallization mother liquor waste water, the processing method prior art to be solved of described this oxytetracycline crystallization mother liquor waste water processes the process of oxytetracycline crystallization mother liquor waste water slowly, the technical problem of poor effect.
The invention discloses the processing method of a kind of oxytetracycline crystallization mother liquor waste water, comprise the steps:
1) step of an oxytetracycline crystallization mother liquor pretreatment, acid solution is added in oxytetracycline crystallization mother liquor, the pH value of oxytetracycline crystallization mother liquor is regulated to PH2-3, is simultaneously introduced polyacrylamide so that polyacrylamide concentration in oxytetracycline crystallization mother liquor is 10-50ppm；
2) one uses the step that organic film separates, and oxytetracycline crystallization mother liquor, between 800-2500 dalton, is divided into film permeate and film trapped fluid by the molecular cut off of described organic film；
3) step that film permeate carries out biochemical treatment, carries out anaerobic-aerobic process to permeate, and the COD of the sewage system after anaerobic-aerobic process is less than 100ppm；
4) film trapped fluid is carried out separating the step obtaining terramycin crude product by one, and film trapped fluid carries out the regulation of pH value, and pH value controls at 4-5, so that product separates out, thus obtains terramycin crude product.
Further, described acid solution is hydrochloric acid.Concrete, the concentration of described hydrochloric acid solution is 1 ~ 3mol/L.
Further, after using the daltonian film of molecular cut off 800-2500 to carry out lock out operation, terramycin content usually 5-25ppm, COD in film permeate are 8000-12000ppm.
Further, carry out separating in the step obtaining terramycin crude product to film trapped fluid at one, add aqueous slkali and film trapped fluid is carried out the regulation of pH value, described aqueous slkali is sodium hydroxide solution or the similar alkaline solution such as sodium bicarbonate solution or sodium carbonate liquor, and the concentration range of described aqueous slkali is 0.1 ~ 5mol/L.
The principle of the present invention is: pre-processed by regulation pH value and interpolation flocculant by oxytetracycline crystallization mother liquor；Crystalline mother solution after process enters organic film to carry out filtering lock out operation, and film permeate carries out the biochemical processing process of anaerobic-aerobic, and the waste water after process can row up to standard；The terramycin product contained in film trapped fluid can be by adding alkali regulation isoelectric point so that terramycin crystallization obtains terramycin crude product.Oxytetracycline crystallization mother liquor, its COD is usually 10000-25000ppm, and terramycin content is 400-900ppm, and film concentrate part terramycin product yield is more than 98% after treatment.
The present invention compares with prior art, and its effect is positive and obvious.It is simple that the present invention processes technique, it is easy to industrialization, had both reduced the difficulty of oxytetracycline crystallization mother liquor biochemical treatment, the most recyclable terramycin product, reduces product cost.
The technical process of the present invention is i.e. the sewage disposal process research and design for meeting terramycin factory, and the use of the present invention can make that the sewage disposal process of terramycin factory is smooth and easy to be carried out, simultaneously it is can also be applied to the sewage treatment process of other antibiotic products.
Detailed description of the invention:
Embodiment 1:
Take 120 kg oxytetracycline crystallization mother liquor, terramycin content 920ppm, COD18200ppm, add hydrochloric acid 1450 milliliters regulation PH to 2.8, add 0.1% concentration polyacrylamide 1800 milliliters, enter organic film piece-rate system, organic film molecular cut off 2500 dalton, obtain 108 kilograms of permeate, the product 12ppm Han terramycin in permeate, terramycin product loss 1.3%；Permeate processes through anaerobic-aerobic, and COD is reduced to 95ppm；Film trapped fluid 12 kilograms, regulation isoelectric point separates out terramycin product, and filtration drying obtains terramycin product；
Embodiment 2:
Take 200 kilograms of oxytetracycline crystallization mother liquors, terramycin content 720ppm, COD14200ppm, add hydrochloric acid 2450 milliliters regulation PH to 2.3, enter organic film piece-rate system, organic film molecular cut off 1000 dalton, obtain 175 kilograms of permeate, the product 8ppm Han terramycin in permeate, terramycin product loss 0.9%；Permeate processes through anaerobic-aerobic, and COD is reduced to 80ppm；Film trapped fluid 25 kilograms, adds alkali regulation isoelectric point and separates out terramycin product, and filtration drying obtains terramycin product.
Claims (1)
1. the processing method of an oxytetracycline crystallization mother liquor waste water, it is characterised in that comprise the steps:
1) step of an oxytetracycline crystallization mother liquor pretreatment, in the step of described oxytetracycline crystallization mother liquor pretreatment, acid solution is added in oxytetracycline crystallization mother liquor, described acid solution is hydrochloric acid, the pH value of oxytetracycline crystallization mother liquor is regulated to pH2～pH3, being simultaneously introduced polyacrylamide, making polyacrylamide concentration in oxytetracycline crystallization mother liquor is 10～50ppm；
2) one uses the step that organic film separates, use in the step that organic film separates described, the molecular cut off of described organic film is between 800～2500 dalton, utilizing organic film that oxytetracycline crystallization mother liquor is divided into film permeate and film trapped fluid, the terramycin content in film permeate is 5～25ppm, COD are 8000～12000ppm；
3) step that film permeate carries out biochemical treatment, in the described step that film permeate carries out biochemical treatment, carries out anaerobic-aerobic process to permeate, and the COD of the sewage system after anaerobic-aerobic process is less than 100ppm；
4) film trapped fluid is carried out separating the step obtaining terramycin crude product by one, carry out film trapped fluid separating in the step obtaining terramycin crude product described, add aqueous slkali and film trapped fluid is carried out the regulation of pH value, described aqueous slkali is sodium hydroxide solution or sodium bicarbonate solution or sodium carbonate liquor, pH value controls at pH4～pH5, make product separate out, thus obtain terramycin crude product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510138634.8A CN104724891B (en) | 2015-03-27 | 2015-03-27 | A kind of processing method of oxytetracycline crystallization mother liquor waste water |
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| CN201510138634.8A CN104724891B (en) | 2015-03-27 | 2015-03-27 | A kind of processing method of oxytetracycline crystallization mother liquor waste water |
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| CN104724891A CN104724891A (en) | 2015-06-24 |
| CN104724891B true CN104724891B (en) | 2016-09-07 |
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| CN108191692A (en) * | 2017-12-25 | 2018-06-22 | 安徽永生堂药业有限责任公司 | A kind of process for separation and purification of tetracycline antibiotics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407473A (en) * | 2008-11-28 | 2009-04-15 | 宁夏启元药业有限公司 | Method for recycling abricycline from abricycline crystal mother liquor |
| CN101781035A (en) * | 2009-12-14 | 2010-07-21 | 同济大学 | Method for recovering terramycin from terramycin production wastewater. |
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2015
- 2015-03-27 CN CN201510138634.8A patent/CN104724891B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407473A (en) * | 2008-11-28 | 2009-04-15 | 宁夏启元药业有限公司 | Method for recycling abricycline from abricycline crystal mother liquor |
| CN101781035A (en) * | 2009-12-14 | 2010-07-21 | 同济大学 | Method for recovering terramycin from terramycin production wastewater. |
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