CN104719335A - Chlorine dioxide controllable sustained release preparation - Google Patents
Chlorine dioxide controllable sustained release preparation Download PDFInfo
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- CN104719335A CN104719335A CN201510108869.2A CN201510108869A CN104719335A CN 104719335 A CN104719335 A CN 104719335A CN 201510108869 A CN201510108869 A CN 201510108869A CN 104719335 A CN104719335 A CN 104719335A
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- chlorine dioxide
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- release preparation
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Abstract
The invention relates to the technical field of environmental purification, and in particular discloses a chlorine dioxide controllable sustained release preparation. The chlorine dioxide controllable sustained release preparation comprises a sustained release carrier and a chlorine dioxide precursor, wherein the sustained release carrier is viscous liquid with flowability and is prepared from the following components in percentage by mass: 0.5-3.5% of a sustained release agent, 0.1-3% of a thickening agent, 0.05-10% of an activating agent and the balance of water; an application method comprises the following steps: putting the chlorine dioxide precursor into the sustained release carrier, and directly placing in an environment; and chlorine dioxide gas which is slowly released in an application process can be used for reducing pollutants such as formaldehyde, ammonia and benzene series in the environment, secondary pollution cannot be caused, and thus the environmental requirements can reach the national standard. The chlorine dioxide controllable sustained release preparation disclosed by the invention has the beneficial effects as follows: the chlorine dioxide controllable sustained release preparation is strong in product stability and long in storage period; the process time cannot be limited because the sustained release carrier has flowability; the chlorine dioxide controllable sustained release preparation is simple and safe to produce and operate, and is more suitable for industrialization; and the purpose of slowly releasing chlorine dioxide can also be achieved by changing the content of the activating agent in the sustained release carrier and changing the thickness of the sustained release carrier.
Description
Technical field
The present invention relates to a kind of technical field of environmental purification, be specifically related to a kind of chlorine dioxide controllable sustained-release preparation.
Background technology
Along with social development, the understanding that the mankind endanger to environmental pollutants is more and more darker, and the consciousness of initiatively seeking Environment control is stronger.Respective market there is various administering method, mainly contained physical method, biological method and chemical method.Wherein physical method take acticarbon as representative, with low cost, but governance process is slow, and easy desorption produces secondary pollution; Biological method produces photoelectric effect when mainly utilizing plant to carry out photosynthesis, remove pollutant, but plant action effect is very limited, at most can only as the supplementary means of environmental improvement; Chemical method representative species has photocatalyst, chlorine dioxide etc. again, photocatalyst because of its cost of manufacture high, action condition is harsh, makes it apply and is restricted; Chlorine dioxide, as the efficient disinfectant of New-type wide-spectrum, is applied to depollution of environment aspect gradually, but the character of chlorine dioxide is very unstable, how to keep the safety in production, and can stablize the technical field that controlled release chlorine dioxide is worth discussion.
Chlorine dioxide is the forth generation efficient sterilization disinfectant of generally acknowledging in the world, and the World Health Organization assert that its safety is A I grade, and some pollutants in surrounding environment can also be carried out oxidative degradation by its strong oxidizing property simultaneously, are degraded to nontoxic material.Patent document CN2631500Y, chlorine dioxide powder raw material is made up of sodium chlorite and citric acid, and sodium chlorite taboo is joined material and is acids, so its industrial operation has certain risk, secondly chlorine dioxide powder raw material is placed on supporter surface, does not reach good slow release effect; Patent document CN201431647Y, the in-built agar of box body is as chlorine dioxide matrix (chlorite) gel, and chlorite is oxidizing species, and it and agar gel have chemical reaction, shortens the shelf-life, is unfavorable for suitability for industrialized production; Patent document CN103931652A, is sodium chlorite, acrylamide, bisacrylamide, borax and potassium peroxydisulfate are dissolved respectively, mixes in proportion, add tetramethylethylenediamine after packing, then there is the shortcoming such as production process complexity, production operation requirement height.
Summary of the invention
The present invention in order to solve in background technology existing problem, provide a kind of stability strong, can the simple and safe chlorine dioxide controllable sustained-release preparation of flexible modulation chlorine dioxide rate of release, production operation.
The present invention is by the following technical solutions:
A kind of chlorine dioxide controllable sustained-release preparation comprises slow-released carrier and chlorine dioxide precursor thing;
And described slow-released carrier is the viscous liquid with mobility, the mass percent of each composition is:
And chlorine dioxide precursor thing can be suspended in slow-released carrier inside, slow releasing chlorine dioxide during described use;
And described sustained release agent is the mixture of one or more of sodium carboxymethylcellulose, carragheen, guar gum and precoking starch;
And described thickener is the mixture of one or more of Macrogol 4000 and Macrogol 6000;
And described activator is the mixture of one or more of citric acid, tartaric acid and malic acid;
And described chlorine dioxide precursor thing be sodium chlorite, the ratio of sodium carbonate, sodium hydroxide is 3 ︰ 1 ︰ 1;
And described chlorine dioxide precursor thing be packaged as non-woven bag;
Action principle of the present invention is that chlorine dioxide precursor thing touches slow-released carrier, and the activator in slow-released carrier by sodium chlorite activation wherein, can produce chlorine dioxide; Because slow-released carrier is the viscous liquid with mobility, so chlorine dioxide precursor thing can be suspended in slow-released carrier inside completely, the chlorine dioxide of generation is discharged in environment through the slow-released carrier layer of surrounding, reaches the object of slow releasing.
Sodium chlorite is stable in alkaline environment, and be suitable for industrial operation, so add alkaline matter sodium carbonate, sodium hydroxide in chlorine dioxide precursor thing, make chlorine dioxide precursor objects system more stable, production operation is safer.
Advantage of the present invention and beneficial effect are:
(1) product stability is strong, and the storage life is long;
(2) product slow-released carrier has mobility, make the process time unrestricted, and production operation is simple and safe, is more suitable for suitability for industrialized production;
(3) product is by changing the thickness of activator levels, slow-released carrier, can realize the controllability to chlorine dioxide rate of release.
Embodiment
Embodiment one: this embodiment by the following technical solutions: by formula precise sodium carboxymethylcellulose 25g, guar gum 150g, citric acid 2.5g, add 4822.5g water and stir 10min, be heated to 90 DEG C, be cooled to room temperature and be distributed into 100g/ box, after packing, be slow-released carrier; By sodium chlorite 150g, sodium carbonate 50g, sodium hydroxide 50g, mix and be distributed into 5g/ non-woven bag, after packing, be chlorine dioxide precursor thing; During use, 1 bag of chlorine dioxide precursor thing is placed on 1 box slow-released carrier inner;
50 square meters newly fit up room, and actual measurement content of formaldehyde is 0.32mg/m
3, in the middle of room, the 1 box chlorine dioxide controllable sustained-release preparation configured above is placed on overhead 1.5m place, and close the doors and windows, testing content of formaldehyde after 24h is 0.011mg/m
3, clearance is 96.5%, and Formaldehyde in Environment concentration is up to state standards 0.1mg/m
3below.
Embodiment two: this embodiment by the following technical solutions: by formula precise sodium carboxymethylcellulose 175g, carragheen 5g, citric acid 300g, tartaric acid 200g, add 4320g water and stir 10min, be heated to 90 DEG C, be cooled to room temperature and be distributed into 50g/ box, after packing, be slow-released carrier; By sodium chlorite 150g, sodium carbonate 50g, sodium hydroxide 50g, mix and be distributed into 2.5g/ non-woven bag, after packing, be chlorine dioxide precursor thing; During use, 1 bag of chlorine dioxide precursor thing is placed on 1 box slow-released carrier inner;
The Japanese tatami of new purchase, airtight rear actual measurement content of formaldehyde is 1.05mg/m
3, be placed in the middle of tatami by the 1 box chlorine dioxide controllable sustained-release preparation configured above, build lid, testing content of formaldehyde after 24h is 0.045mg/m
3, clearance is 95.7%, and environment concentration of formaldehyde is up to state standards 0.1mg/m
3below.
Claims (8)
1. a chlorine dioxide controllable sustained-release preparation, is characterized in that comprising slow-released carrier and chlorine dioxide precursor thing.
2. a kind of chlorine dioxide controllable sustained-release preparation according to claim 1, it is characterized in that described slow-released carrier is the viscous liquid with mobility, the mass percent of each composition is:
。
3. a kind of chlorine dioxide controllable sustained-release preparation according to claim 1, when it is characterized in that using, chlorine dioxide precursor thing can be suspended in slow-released carrier inside, slow releasing chlorine dioxide.
4. a kind of chlorine dioxide controllable sustained-release preparation according to claim 1 and 2, is characterized in that described sustained release agent is the mixture of one or more of sodium carboxymethylcellulose, carragheen, guar gum and precoking starch.
5. a kind of chlorine dioxide controllable sustained-release preparation according to claim 1 and 2, is characterized in that described thickener is the mixture of one or more of Macrogol 4000 and Macrogol 6000.
6. a kind of chlorine dioxide controllable sustained-release preparation according to claim 1 and 2, is characterized in that described activator is the mixture of one or more of citric acid, tartaric acid and malic acid.
7. a kind of chlorine dioxide controllable sustained-release preparation according to claim 1 and 2, is characterized in that described chlorine dioxide precursor thing is sodium chlorite, the ratio of sodium carbonate, sodium hydroxide is 3 ︰ 1 ︰ 1.
8. a kind of chlorine dioxide controllable sustained-release preparation according to claim 1 and 2, what it is characterized in that described chlorine dioxide precursor thing is packaged as non-woven bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510108869.2A CN104719335A (en) | 2015-03-13 | 2015-03-13 | Chlorine dioxide controllable sustained release preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510108869.2A CN104719335A (en) | 2015-03-13 | 2015-03-13 | Chlorine dioxide controllable sustained release preparation |
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| CN104719335A true CN104719335A (en) | 2015-06-24 |
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| CN201510108869.2A Pending CN104719335A (en) | 2015-03-13 | 2015-03-13 | Chlorine dioxide controllable sustained release preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106538599A (en) * | 2016-11-08 | 2017-03-29 | 东北大学秦皇岛分校 | A kind of stable chlorite compositions and preparation method thereof |
| CN111066814A (en) * | 2019-11-23 | 2020-04-28 | 南阳市天华制药有限公司 | Novel slow-release gas disinfectant and preparation method thereof |
| CN116649362A (en) * | 2023-07-31 | 2023-08-29 | 山东华实药业有限公司 | Chlorine dioxide disinfection tablet and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1064845A1 (en) * | 1999-06-30 | 2001-01-03 | Kao Corporation | Virucidal and sporicidal composition |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
| CN101810874A (en) * | 2009-12-15 | 2010-08-25 | 北京欧凯纳斯科技有限公司 | Sustained-release chlorine dioxide gel, preparation method and application thereof |
| CN103155945A (en) * | 2013-04-09 | 2013-06-19 | 中国人民解放军军事医学科学院卫生装备研究所 | Retarding gas chlorine dioxide solid generating preparation |
-
2015
- 2015-03-13 CN CN201510108869.2A patent/CN104719335A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1064845A1 (en) * | 1999-06-30 | 2001-01-03 | Kao Corporation | Virucidal and sporicidal composition |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
| CN101810874A (en) * | 2009-12-15 | 2010-08-25 | 北京欧凯纳斯科技有限公司 | Sustained-release chlorine dioxide gel, preparation method and application thereof |
| CN103155945A (en) * | 2013-04-09 | 2013-06-19 | 中国人民解放军军事医学科学院卫生装备研究所 | Retarding gas chlorine dioxide solid generating preparation |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106538599A (en) * | 2016-11-08 | 2017-03-29 | 东北大学秦皇岛分校 | A kind of stable chlorite compositions and preparation method thereof |
| CN106538599B (en) * | 2016-11-08 | 2020-05-19 | 东北大学秦皇岛分校 | Stable chlorite composition and preparation method thereof |
| CN111066814A (en) * | 2019-11-23 | 2020-04-28 | 南阳市天华制药有限公司 | Novel slow-release gas disinfectant and preparation method thereof |
| CN116649362A (en) * | 2023-07-31 | 2023-08-29 | 山东华实药业有限公司 | Chlorine dioxide disinfection tablet and preparation method thereof |
| CN116649362B (en) * | 2023-07-31 | 2023-09-26 | 山东华实药业有限公司 | Chlorine dioxide disinfection tablet and preparation method thereof |
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Application publication date: 20150624 |