CN104707263A - Energy transmitting system - Google Patents
Energy transmitting system Download PDFInfo
- Publication number
- CN104707263A CN104707263A CN201510013609.7A CN201510013609A CN104707263A CN 104707263 A CN104707263 A CN 104707263A CN 201510013609 A CN201510013609 A CN 201510013609A CN 104707263 A CN104707263 A CN 104707263A
- Authority
- CN
- China
- Prior art keywords
- present
- applicator
- tissue
- vacuum
- antenna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001816 cooling Methods 0.000 claims abstract description 59
- 230000004888 barrier function Effects 0.000 claims description 172
- 230000000712 assembly Effects 0.000 claims description 62
- 238000000429 assembly Methods 0.000 claims description 62
- 230000005540 biological transmission Effects 0.000 claims description 38
- 238000009826 distribution Methods 0.000 claims description 19
- 239000012528 membrane Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 230000000644 propagated effect Effects 0.000 claims description 4
- 239000003989 dielectric material Substances 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 356
- 238000000034 method Methods 0.000 description 171
- 239000002826 coolant Substances 0.000 description 149
- 238000011282 treatment Methods 0.000 description 112
- 230000008569 process Effects 0.000 description 107
- 239000012809 cooling fluid Substances 0.000 description 77
- 210000003491 skin Anatomy 0.000 description 65
- 239000000463 material Substances 0.000 description 39
- 238000000926 separation method Methods 0.000 description 37
- 239000000945 filler Substances 0.000 description 36
- 230000006378 damage Effects 0.000 description 35
- 230000002441 reversible effect Effects 0.000 description 35
- 239000012530 fluid Substances 0.000 description 22
- 238000010586 diagram Methods 0.000 description 21
- 238000003860 storage Methods 0.000 description 19
- 230000008878 coupling Effects 0.000 description 18
- 238000010168 coupling process Methods 0.000 description 18
- 238000005859 coupling reaction Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 14
- 230000001225 therapeutic effect Effects 0.000 description 13
- 239000011248 coating agent Substances 0.000 description 12
- 238000000576 coating method Methods 0.000 description 12
- 238000002560 therapeutic procedure Methods 0.000 description 11
- 238000002372 labelling Methods 0.000 description 10
- 230000005855 radiation Effects 0.000 description 10
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 9
- 208000027418 Wounds and injury Diseases 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 208000014674 injury Diseases 0.000 description 9
- 230000000306 recurrent effect Effects 0.000 description 9
- 230000006835 compression Effects 0.000 description 7
- 238000007906 compression Methods 0.000 description 7
- 230000002209 hydrophobic effect Effects 0.000 description 7
- 230000003533 narcotic effect Effects 0.000 description 7
- 238000007747 plating Methods 0.000 description 7
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 6
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 6
- 210000004209 hair Anatomy 0.000 description 6
- 238000002955 isolation Methods 0.000 description 6
- 229960004194 lidocaine Drugs 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 208000008454 Hyperhidrosis Diseases 0.000 description 5
- 230000037315 hyperhidrosis Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 230000008520 organization Effects 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000004809 Teflon Substances 0.000 description 4
- 229920006362 Teflon® Polymers 0.000 description 4
- 239000006096 absorbing agent Substances 0.000 description 4
- 206010000496 acne Diseases 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003822 epoxy resin Substances 0.000 description 4
- 210000003780 hair follicle Anatomy 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 229920000052 poly(p-xylylene) Polymers 0.000 description 4
- 229920000647 polyepoxide Polymers 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000003507 refrigerant Substances 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 210000000106 sweat gland Anatomy 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 230000001902 propagating effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 206010004950 Birth mark Diseases 0.000 description 2
- 208000035985 Body Odor Diseases 0.000 description 2
- 206010055000 Bromhidrosis Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010067193 Naevus flammeus Diseases 0.000 description 2
- 208000006787 Port-Wine Stain Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000011358 absorbing material Substances 0.000 description 2
- 230000001166 anti-perspirative effect Effects 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- 210000000040 apocrine gland Anatomy 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- XEGGRYVFLWGFHI-UHFFFAOYSA-N bendiocarb Chemical compound CNC(=O)OC1=CC=CC2=C1OC(C)(C)O2 XEGGRYVFLWGFHI-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000589 cicatrix Anatomy 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 210000003499 exocrine gland Anatomy 0.000 description 2
- 208000002026 familial multiple nevi flammei Diseases 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 229910001006 Constantan Inorganic materials 0.000 description 1
- 239000004425 Makrolon Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001490213 Milium Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000003660 hair regeneration Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000000976 ink Substances 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000005067 joint tissue Anatomy 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 201000000195 skin tag Diseases 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Abstract
The invention provides an energy transmitting system comprisng an energy transmitting applicator, a disposable interface on a far end of the applicator, an anthenna structure and a cooling loop.
Description
The application is divisional application, and the application number of original application is 200880126637.8, and the applying date is December in 2008 12 days, and denomination of invention is " disposable medical equipment and system thereof ".
Related application
This application claims the U.S. Provisional Patent Application the 61/196th that the name submitted on October 22nd, 2008 is called " SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE; SUCH AS SWEAT GLANDS ", the rights and interests of No. 948, are incorporated to its full content herein as a reference at this.
The application is also the co-pending U.S. Patent application the 12/107th that the name submitted on April 21st, 2008 is called " SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE ", the part continuation application of No. 025, the name of this co-pending U.S. Patent application requirement submission on April 19th, 2007 is called the U.S. Provisional Patent Application the 60/912nd of " METHODS AND APPARATUS FOR REDUCING SWEAT PRODUCTION ", No. 899, the name of December in 2007 submission on the 12nd is called the U.S. Provisional Patent Application the 61/013rd of " METHODS, DEVICES AND SYSTEMS FOR NON-INVASIVE DELIVERY OF MICROWAVE THERAPY ", the name submitted in No. 274 and on April 17th, 2008 is called the U.S. Provisional Patent Application the 61/045th of " SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY IN SPECIFIED TISSUE ", the rights and interests of No. 937.Be incorporated to specially herein as a reference at the full content of this all above-mentioned priority application.
Co-pending U.S. Patent application the 12/107th, No. 025 name also requiring on April 18th, 2008 to submit to is called No. PCT/US08/60935th, the PCT application of " METHODS AND APPARATUS FOR SWEAT PRODUCTION ", the name that on April 18th, 2008 submits to is called " METHODS, DEVICES, AND SYSTEMS FOR NON-INVASIVE DELIVERY OF MICROWAVE THERAPY " No. PCT/US08/60929th, PCT application and the name submitted on April 18th, 2008 be called that the name submitted in No. PCT/US08/60940th, the PCT application of " SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE " and on April 18th, 2008 is called the priority of No. PCT/US08/60922nd, the PCT application of " SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE ".Be incorporated to specially herein as a reference at the full content of this all above-mentioned priority application.
Technical field
The application relates to the method, apparatus and system of noinvasive microwave transmission treatment.Particularly, the application relate to the epidermal tissue of patient, dermal tissue and subcutaneous tissue non-invasively transmission of power (such as microwave energy) to realize the method, apparatus and system of various therapeutic effect and/or aesthetic effect.
Background technology
Be well known that, the therapy based on energy can be applied to spread all over health tissue to realize multiple therapeutic effect and/or aesthetic effect.Still needing to improve these based on the effectiveness of the therapy of energy provides the therapeutic effect of enhancing when having and minimizing adverse side effect or discomfort.
Accompanying drawing explanation
By reference to the accompanying drawings, from the following detailed description of preferred embodiment, be appreciated that the present invention, wherein:
Fig. 1 is the diagram comprising the system of generator, applicator and disposable device (disposable) according to an embodiment of the present.
Fig. 2 is the axonometric chart of applicator according to an embodiment of the present and disposable device.
Fig. 3 is the end-view of the far-end of the applicator shown in Fig. 2 and disposable device.
Fig. 4 is the exploded perspective view of the applicator shown in Fig. 2 and disposable device.
Fig. 5 is the axonometric chart of disposable device according to an embodiment of the present.
Fig. 6 is the sectional view intercepted along the E-E of the disposable device shown in Fig. 5.
Fig. 7 is the axonometric chart of antenna holder according to an embodiment of the present.
Fig. 8 is the sectional view intercepted along the K-K of the antenna holder shown in Fig. 7.
Fig. 9 is the axonometric chart of aerial array according to an embodiment of the present and disposable device.
Figure 10 is the sectional view intercepted along the A-A of the aerial array shown in Fig. 9 and disposable device.
Figure 11 is the sectional view intercepted along the B-B of the aerial array shown in Fig. 9 and disposable device.
Figure 12 is the axonometric chart of aerial array according to an embodiment of the present.
Figure 13 is the sectional view intercepted along the C-C of the aerial array shown in Figure 12.
Figure 14 is the sectional view intercepted along the D-D of the aerial array shown in Figure 12.
Figure 15 is the sectional view intercepted along the C-C of the distal portions of the aerial array shown in Figure 12.
Figure 16 shows coldplate according to an embodiment of the present and thermocouple.
Figure 17 is the sectional view intercepted along the J-J of a part for the coldplate shown in Figure 16 and thermocouple.
Figure 18 is the sectional view intercepted along the J-J of a part for the coldplate shown in Figure 16 and thermocouple.
Figure 19 is the perspective end view of aerial array, coolant cavity, separation rib and dispersing element according to an embodiment of the present.
Figure 20 is the end-view of the aerial array shown in Figure 19, coolant cavity, separation rib and dispersing element.
Figure 21 is the axonometric chart of applicator according to an embodiment of the present and disposable device.
Figure 22 is the end-view of the far-end of the applicator shown in Figure 21 and disposable device.
Figure 23 is the exploded perspective view of the applicator shown in Figure 21.
Figure 24 is the sectional view of the applicator shown in Figure 21.
Figure 25 is the view of the far-end of disposable device according to an embodiment of the present.
Figure 26 is the view of the proximal lateral of the disposable device shown in Figure 25.
Figure 27 is the view of the first paragraph of the proximal lateral of the disposable device shown in Figure 26.
Figure 28 is the view of the second segment of the proximal lateral of the disposable device shown in Figure 26.
Figure 29 is the sectional view intercepted along the H-H of the disposable device shown in Figure 25.
Figure 30 is the view of a section of the disposable device shown in Figure 29.
Figure 30 A is the view of a section of alternate embodiments according to the present invention disposable device shown in Figure 29.
Figure 30 B is the view of a section of alternate embodiments according to the present invention disposable device shown in Figure 29.
Figure 31 is the axonometric chart of antenna holder according to an embodiment of the present.
Figure 32 is the three-dimensional cutaway view intercepted along the F-F of the antenna holder shown in Figure 31.
Figure 33 is the sectional view intercepted along the F-F of the antenna holder shown in Figure 31.
Figure 34 is the three-dimensional cutaway view of the I-I intercepting of a section along the antenna holder shown in Figure 31.
Figure 35 is the axonometric chart of aerial array according to an embodiment of the present.
Figure 36 is the sectional view intercepted along the I-I of the aerial array shown in Figure 35.
Figure 37 is the view of the first paragraph of the sectional view of the aerial array shown in Figure 36.
Figure 38 is the axonometric chart of the second segment of the sectional view of the aerial array shown in Figure 36.
Figure 39 is the view of the 3rd section of the sectional view of the aerial array shown in Figure 36.
Figure 40 is the end-view of the aerial array shown in Figure 35 not having coldplate.
Figure 41 is the axonometric chart of waveguide assemblies according to an embodiment of the present.
Figure 42 is the side view of the waveguide assemblies shown in Figure 41.
Figure 43 is the sectional view intercepted along the G-G of the waveguide assemblies shown in Figure 41.
Figure 44 is the view of a section of the sectional view of the waveguide assemblies shown in Figure 43.
Figure 45 is the side view of the alternate embodiments of waveguide assemblies according to an embodiment of the present.
Figure 46 is the sectional view of the waveguide assemblies shown in Figure 45.
Figure 47 is the schematic diagram of system according to an embodiment of the present.
Figure 48 is the schematic diagram of microwave links according to an embodiment of the present.
Figure 49 is the schematic diagram of controller according to an embodiment of the present.
Figure 50 is the schematic diagram of rear board according to an embodiment of the present.
Figure 51 is the schematic diagram of front panel according to an embodiment of the present.
Figure 52 is the schematic diagram of vacuum source according to an embodiment of the present.
Figure 53 is the schematic diagram of Controller Circuit Used in Microwave Power Amplifier according to an embodiment of the present.
Figure 54-58 is schematic diagrams of patient's positioning equipment according to an embodiment of the present.
Figure 59 is the schematic diagram for the treatment of model according to an embodiment of the present.
Figure 60 is the simple sectional view engaging the medical treatment device of tissue according to an embodiment of the present.
Figure 61 shows tissue contours and the reduced graph of medical treatment device according to an embodiment of the present.
Figure 62 shows tissue contours and the reduced graph of medical treatment device according to an embodiment of the present.
Figure 63 shows tissue contours and the reduced graph of medical treatment device according to an embodiment of the present.
Figure 64 shows tissue contours and the reduced graph of medical treatment device according to an embodiment of the present.
Detailed description of the invention
Although present disclosure is concrete and be accurate to and make those skilled in the art can implement the present invention, but tangible embodiment disclosed herein is only for exemplifying the present invention and the present invention may be implemented as other ad hoc structures.Although describe preferred embodiment, but not deviating from the situation of the present invention that claim limits, can modify to details.
Fig. 1 is the diagram of system 2309 according to an embodiment of the present, and this system 2309 comprises generator 2301, applicator 2320(also can be called as reusable) and disposable device 2363.According to an embodiment of the present, generator 2301 runs in the ISM bandwidth of 5.775 to 5.825 GHz.According to an embodiment of the present, generator 2301 comprises circuit so that setting and control output; Measure forward and reverse power and setting to report to the police.According to an embodiment of the present, generator 2301 can have the frequency centered by 5.8 GHz.According to an embodiment of the present, generator 2301 can have the power stage between 40 to 100 watts when 50 ohm load are measured.According to an embodiment of the present, generator 2301 can have the power accuracy of positive/negative 3 watts.According to an embodiment of the present, disposable device 2363 and applicator 2320 can be formed separable two unit.According to an embodiment of the present, disposable device 2363 and applicator 2320 can be formed individual unit.According to an embodiment of the present, when joined, disposable device 2363 and applicator 2320 can form medical treatment device 2300.According to an embodiment of the present, generator 2301 can be microwave generator.According to an embodiment of the present, can be that head organized by disposable device 2363.According to an embodiment of the present, in system 2309, applicator 2320 can be connected to generator 2301 by applicator cable 2334.According to an embodiment of the present, in system 2309, applicator cable 2334 can comprise coolant conduit 2324, energy cable 2322, coolant thermocouple electric wire 2331, coldplate thermocouple electric wire 2330 and duplexer signal 2481.According to an embodiment of the present, in system 2309, it can be the industry of the Nanotherm with the 8 psi pumps recycle cooler that such as can obtain from ThermoTek, Inc that coolant conduit 2324 can be connected to this coolant source 2310 of coolant source 2310().According to an embodiment of the present, in system 2309, energy cable 2322 can be connected to generator 2301 by microwave out connector 2443.According to an embodiment of the present, in system 2309, duplexer signal 2481 can be connected to generator 2301 by duplexer adapter 2480.According to an embodiment of the present, in system 2309, disposable device 2363 can be connected to generator 2301 by vacuum tube 2319, and it is such as the generator biological barrier 2317 of hydrophobic filter that this vacuum tube 2319 can comprise.According to an embodiment of the present, in system 2309, vacuum tube 2319 can be connected to generator 2301 by vacuum ports adapter 2484.According to an embodiment of the present, in system 2309, the front panel 2305 of generator 2301 can comprise power control handle 2454, vacuum control knob 2456, antenna selection switch 2462(can comprise display element and selector switch), vacuometer measuring device 2486, antenna temperature display 2458, coolant temperature display 2460, pre-cooling timer 2468(can comprise display element and time setting member), energy timer 2470(can comprise display element and time setting member) and rear cooling timer 2472(can comprise display element and time setting member).According to an embodiment of the present, if measuring-signal exceeds the specification of the request power that the power control handle 2454 on front panel 2305 sets, then error signal is sent to the controller 2302 of generator 2301.According to an embodiment of the present, if the reverse power measured is greater than the default restriction to the reverse power measured, then error signal is sent to controller 2302.According to an embodiment of the present, if the reverse power measured is greater than approximate 25 watts, then error signal is sent to controller 2302.According to an embodiment of the present, vacuum tube 2319 can comprise flexible vacuum hose 2329 and generator biological barrier 2317.According to an embodiment of the present, flexible vacuum hose 2329 is suitable for collecting and may spills from disposable device 2363 thus can not arrive the fluid of generator 2301, such as antiperspirant or blood.According to an embodiment of the present, generator biological barrier 2317 can comprise hydrophobic filter to the vacuum ports adapter 2484 stoping fluid to enter generator 2301.According to an embodiment of the present, generator biological barrier 2317 can comprise hydrophobic filter, the Millex FH filter be made up of 0.45 micron hydrophobic PTFE that such as can obtain from Milipore.According to an embodiment of the present, generator biological barrier 2317 can be positioned at flexible hose.According to an embodiment of the present, generator 2301 can be connected to applicator 2320 by applicator cable 2334.According to an embodiment of the present, applicator cable 2334 can comprise coolant conduit 2324, energy cable 2322, duplexer signal 2481, coldplate thermocouple electric wire 2330 and coolant thermocouple electric wire 2331.According to an embodiment of the present, applicator cable 2334 can also comprise thermocouple arrays cable.According to an embodiment of the present, cooling fluid can be transported to applicator 2320 from coolant source 2310 by coolant conduit 2324.According to an embodiment of the present, microwave switch can be selected data to be transported to applicator 2320 and temperature data is transported to generator 2301 from the thermocouple applicator 2320 by applicator cable 2334.According to an embodiment of the present, applicator cable 2334 can comprise one or more independent cable and adapter.According to an embodiment of the present, generator adapter can be designed to and be applicable to applicator cable 2334 to be connected to generator 2301, comprise control for cooling fluid duct, duplexer, the connection of thermocouple and main microwave connector.
Fig. 2 is the axonometric chart of applicator 2320 according to an embodiment of the present and disposable device 2363.According to an embodiment of the present, applicator 2320 latched mechanism 2365 can be attached to disposable device 2363.According to an embodiment of the present, applicator 2320 can comprise applicator cable 2334.According to an embodiment of the present, disposable device 2363 can comprise vacuum tube 2319, tissue cavity 2338 and tissue boundary surface 2336.According to an embodiment of the present, tissue cavity 2338 can be that destination organization can be located so that the hole of emphasis treatment.According to an embodiment of the present, tissue boundary surface 2336 can comprise tissue biological's barrier 2337, vacuum ports 2342 and vacuum passage 2350.According to an embodiment of the present, vacuum ports 2342 can be positioned at around the outward flange on tissue boundary surface 2336.According to an embodiment of the present, vacuum ports 2342 can be configured to substantially equidistant each other.According to an embodiment of the present, vacuum ports 2342 on average can be arranged around interface surface.According to an embodiment of the present, vacuum ports 2342 can around tissue biological's barrier.According to an embodiment of the present, vacuum ports 2342 can be positioned in apart from wall 2354 preset distance place, chamber.According to an embodiment of the present, vacuum ports 2342 can have complete open area and be oriented to be enough to obtain and the tissue kept in tissue cavity 2338.According to an embodiment of the present, vacuum ports 2342 can be evenly distributed around tissue cavity 2338 to contribute to striding across tissue cavity 2338 obtaining tissue equally.According to an embodiment of the present, vacuum ports 2342 can be symmetrical to contribute to obtaining tissue symmetrically around tissue cavity 2338.According to an embodiment of the present, approximate 28 vacuum ports 2342 can such as be had in tissue boundary surface 2336.According to an embodiment of the present, vacuum ports 2342 can contact vacuum passage 2350.According to an embodiment of the present, tissue cavity 2338 is connected to vacuum loop 2341 by vacuum ports 2342.According to an embodiment of the present, vacuum passage 2350 can be oriented to flow around tissue biological's barrier 2337 with at least one in vacuum ports 2342 contact.According to an embodiment of the present, vacuum passage 2350 is auxiliary when applying the vacuum pressure keeps tissue in place.According to an embodiment of the present, vacuum passage 2350 is assisted and produce suction sign (this suction sign can be called as impression and indicate) on patient skin.According to an embodiment of the present, doctor or user can use suction to indicate and identify the region be treated.According to an embodiment of the present, laser in disposable device 2363 is integrated in or other light sources can be used to before applicator is applied to tissue as user provides guiding to indicate area for treatment.According to an embodiment of the present, vacuum loop 2341 can separate the vacuum pressure applied by such as vacuum tube 2319 between tissue cavity 2338 and applicator chamber 2346.According to an embodiment of the present, when fluid flows in applicator chamber 2346 or when forbidding that it flows from tissue cavity 2338, vacuum loop 2341 can be suitable for the air pressure of balanced tissue biological's barrier both sides.According to an embodiment of the present, the vacuum passage 2350 in tissue boundary surface 2336 can be organized in the auxiliary maintenance of treatments period and prevent tissue from peeling off from tissue boundary surface 2336.According to an embodiment of the present, the vacuum sound in tissue cavity 2338 can provide the correct sound instruction obtaining tissue for user.According to an embodiment of the present, as long as user can hear vacuum sound, then organize and be not correctly positioned in tissue cavity 2338.
Fig. 3 is the end-view of the far-end of the applicator 2320 shown in Fig. 2 and disposable device 2363.According to an embodiment of the present, disposable device 2363 can comprise can be such as tissue biological's barrier 2337 of flexible membrane.According to an embodiment of the present, disposable device 2363 can comprise can be such as tissue biological's barrier 2337 of polyethylene film.According to an embodiment of the present, applicator 2320 can comprise can be such as be positioned at biological barrier 2337 coldplate 2340 below.According to an embodiment of the present, disposable device 2363 can comprise vacuum ports 2342 and vacuum passage 2350.According to an embodiment of the present, vacuum ports 2342 can be the hole that such as directly or indirectly can be connected with vacuum tube 2319 and vacuum passage 2350 in the far-end of disposable device 2363, and it can be formed by the groove in disposable device 2363.According to an embodiment of the present, disposable device 2363 can comprise chamber opening 2339.According to an embodiment of the present, chamber opening 2339 can be oval.According to an embodiment of the present, chamber opening 2339 can be approximate 35 mm wide × 50 millimeters long.According to an embodiment of the present, tissue cavity 2338 can be similar to 7 millimeters deep.
According to an embodiment of the present, tissue biological's barrier 2337 can be oriented to provide sealing when disposable device 2363 is attached to applicator 2320.According to an embodiment of the present, tissue biological's barrier 2337 can be suitable for preventing any bioresorbable on skin and skin from comprising the applicator 2320 of coldplate 2340.According to an embodiment of the present, tissue biological's barrier 2337 can be oriented to extend across coldplate 2340 when disposable device 2363 is attached to applicator 2320.According to an embodiment of the present, tissue biological's barrier 2337 is designed to the conductive heat loss of coldplate 2340/ tissue biological barrier 2337 molectron minimizing combination at least in part.According to an embodiment of the present, tissue biological's barrier 2337 can be have approximate 0.0005 inch thickness flexible membrane and can change between approximate 0.0001 inch to approximate 0.030 inch.According to an embodiment of the present, tissue biological's barrier 2337 can impermeable fluid and substantially impermeable air.According to an embodiment of the present, tissue biological's barrier 2337 can be can the dielectric material of substantially transmissive microwave energy.According to an embodiment of the present, tissue biological's barrier 2337 can be the material of the microwave field do not disturbed through tissue biological's barrier 2337.According to an embodiment of the present, tissue biological's barrier 2337 can be low-loss material.According to an embodiment of the present, tissue biological's barrier 2337 can have the dielectric constant between 2 to 15 and the dielectric constant preferably between 3 to 3.5.According to an embodiment of the present, tissue biological's barrier 2337 can have the Young's modulus between approximate 0.1 GPa to approximate 5 GPa.According to an embodiment of the present, tissue biological's barrier 2337 can have the Young's modulus between approximate 0.1 to approximate 3.1 GPa.According to an embodiment of the present, tissue biological's barrier 2337 can have the Young's modulus between approximate 0.1 to 1.5 GPa.According to an embodiment of the present, tissue biological's barrier 2337 can be the flexible membrane of the such as polyethylene or PET that can form all or part of tissue boundary surface 2336.According to an embodiment of the present, tissue biological's barrier 2337 can be the rigid solid ceramic material of the high-termal conductivity at room temperature had between approximate 1W/ (mK) to approximate 100 W/ (mK) (TS).In alternative embodiments, tissue biological's barrier 2337 can be the rigid solid ceramic material of the high-termal conductivity at room temperature had between approximate 1W/ (mK) to approximate 100 W/ (mK) (TS).According to an embodiment of the present, hard tissue biological's barrier 2337 can eliminate the needs for vacuum loop 2341 in applicator 2320.According to an embodiment of the present, solid ceramic tissue biological barrier 2337 can have the microwave permittivity selected for 5.8 GHz.According to an embodiment of the present, hard tissue biological's barrier 2337 can be made up of the material of dielectric constant of the dielectric constant dielectric constant of 10 (such as approximate) with coupling or approximate match coldplate 2340.According to an embodiment of the present, the material being applicable to hard tissue biological's barrier can comprise the material of the dielectric constant of the value had between 1 to 80, if and the change that the thickness of tissue biological's barrier 2337 is minimized to is enough to guarantee dielectric constant can not affect the microwave transparent of tissue biological's barrier 2337, be then also acceptable.According to an embodiment of the present, tissue biological's barrier 2337 can have be less than approximate 0.001 inch thickness to maximize microwave transparent.According to an embodiment of the present, hard tissue biological's barrier 2337 can by have do not increase coldplate 2340 and be bonded in tissue cavity 2338 tissue between the material of dielectric constant of additional dielectric discontinuity form.According to an embodiment of the present, hard tissue biological's barrier 2337 can be selected to the overall effective thickness minimizing coldplate biological barrier molectron.According to an embodiment of the present, the combination thickness of coldplate 2340 and tissue biological's barrier 2337 can be selected to the reduction of the peak value SAR minimizing coldplate 2340 self.According to an embodiment of the present, the combination thickness of coldplate 2340 and tissue biological's barrier 2337 can be selected to and is less than 0.018 inch to minimize the reduction of the peak value SAR of coldplate 2340 self.According to an embodiment of the present, the combination thickness of coldplate 2340 and tissue biological's barrier 2337 can be selected to and is less than 0.020 inch to minimize the reduction of the peak value SAR of coldplate 2340 self.
Fig. 4 is the exploded perspective view of applicator 2320 shown in Fig. 2 and disposable device 2363.According to an embodiment of the present, applicator 2320 can comprise coldplate 2340, and this coldplate 2340 can comprise one or more thermocouple being attached to coldplate thermocouple electric wire 2330.According to an embodiment of the present, applicator 2320 can comprise separation rib 2393, antenna holder 2374, coolant supply pipe 2312, coolant recurrent canal 2313, radiating guide 2364 (a-d), duplexer 2357 and applicator cable 2334.According to an embodiment of the present, applicator cable 2334 can comprise duplexer signal 2481, energy cable 2322 and coolant conduit 2324.According to an embodiment of the present, applicator cable 2334 can comprise coldplate thermocouple electric wire 2330 and coolant thermocouple electric wire 2331.According to an embodiment of the present, disposable device 2363 can comprise vacuum tube 2319.According to an embodiment of the present, energy cable 2322(can be called as microwave cable) microwave energy is sent to applicator 2320 from generator 2301.According to an embodiment of the present, the duplexer 2357(that microwave energy is sent in applicator 2320 by energy cable 2322 can be called as microwave switch).According to an embodiment of the present, energy cable 2322 can be designed to the output of interested frequency match generator 2301 and applicator 2320.According to an embodiment of the present, energy cable 2322 can be designed to the output of 5.8 GHz matched generators 2301 and applicator 2320.According to an embodiment of the present, energy cable 2322 can have the consume being less than 2dB under 50 ohm load.According to an embodiment of the present, energy cable 2322 can be have the six feet of coaxial cables being less than 2dB consume.According to an embodiment of the present, energy cable 2322 can be flexible cable to maximize the overall flexibility of applicator cable 2334.According to an embodiment of the present, the interconnecting cable 2372 leading to the radiating guide 2364 in aerial array 2355 is preferably balanced and is mated to make the output of each radiating guide 2364 all to have equal-wattage.According to an embodiment of the present, the interconnecting cable 2372 leading to the radiating guide 2364 in aerial array 2355 is preferably balanced and is mated so that by selecting suitable length and type of cable all have equal-wattage to make the output of each radiating guide 2364 thus guarantee the Differential Output between radiating guide 2364 and applicator 2320.According to an embodiment of the present, the interconnecting cable 2372 leading to radiating guide 2364 is coaxial cables of low-loss.According to an embodiment of the present, the interconnecting cable 2372 leading to radiating guide 2364 has the consume being less than 1dB.According to an embodiment of the present, can by the change regulating generator output or power transfer time to compensate coupling.According to an embodiment of the present, antenna holder 2374 can comprise thermocouple guide hole (not shown), and it can be sealed to allow thermocouple electric wire through preventing vacuum leak in the vacuum seal between disposable device 2363 and applicator 2320.According to an embodiment of the present, antenna holder 2374 comprises Support Channel 2389, and cooling fluid flows through this Support Channel 2389 as portion cooling agent loop.According to an embodiment of the present, alternative antenna can comprise electromagnetic horn, many dielectric filler radiating guide, slot antenna, microstrip antenna, paster antenna and Vivaldi antenna.According to an embodiment of the present, duplexer 2357 can be suitable for receiving from the microwave signal of generator and control signal, and changes microwave signal based between the radiating guide 2364 of the control signal received in aerial array 2355.According to an embodiment of the present, duplexer 2357 can be dynamo-electric coaxial microwave relay, such as, can obtain from RealComm Technologies.According to an embodiment of the present, via antenna selection switch, such as, as the antenna selection switch of a part for the antenna selection switch 2462 on generator 2301, one or more antenna in (such as sequentially) startup applicator 2320 can be carried out.According to an embodiment of the present, duplexer 2357(can be called as distribution member) power split between radiating guide 2364 from energy cable 2322 can be suitable for come simultaneously for two or more radiating guides 2364 provide power.According to an embodiment of the present, duplexer 2357 can be the power divider being suitable for the microwave energy simultaneously split between one or more radiating guide 2364.According to an embodiment of the present, microwave energy is sent to duplexer 2357 by energy cable 2322.According to an embodiment of the present, microwave power is transported to each radiating guide 2364 from duplexer 2357 by feeder cable.According to an embodiment of the present, for carrying the cable of microwave energy can be flexible low-loss cable.According to an embodiment of the present, for carrying the cable of microwave energy can have consume between 0 to 2dB under frequency-of-interest.According to an embodiment of the present, for carrying the cable of microwave energy can have consume between 0 to 2dB at the frequency place of approximate 5.8 GHz.According to an embodiment of the present, the impedance for carrying the cable of microwave energy can have approximate 50 ohm.
Fig. 5 is the axonometric chart of disposable device 2363 according to an embodiment of the present.According to an embodiment of the present, disposable device 2363 can comprise tissue biological's barrier 2337, applicator vacuum ports 2327 and also can be called as the applicator chamber 2346 in reusable chamber.According to an embodiment of the present, applicator chamber 2346 can be suitable for receiving the far-end of the applicator 2320 comprising coldplate 2340.According to an embodiment of the present, disposable device 2363 can comprise applicator interface (interface) 2344(and also can be called as reusable interface).According to an embodiment of the present, applicator interface 2344 comprise applicator chamber 2346, vacuum seal 2348, present a theatrical performance as the last item on a programme 2325 and latch component 2359.According to an embodiment of the present, applicator chamber 2346 can be suitable for receiving the far-end of applicator 2320 and the joint contributed between the far-end of applicator 2320 and tissue biological's barrier 2337.According to an embodiment of the present, vacuum seal 2348 can be packing ring, this packing ring can be configured to the outside around applicator chamber 2346, and seals applicator chamber 2346 and prevent vacuum leak when the far-end that can be suitable for engaging applicator 2320 is attached to applicator 2320 with convenient disposable bioreactor part 2363.According to an embodiment of the present, when engaged, vacuum seal 2348 can be similar between 20 percent to approximate 50 percent, to guarantee good vacuum seal and to prevent vacuum leak by compression.According to an embodiment of the present, vacuum seal 2348 can be enough to by compression one section the distance guaranteeing good vacuum seal Leakage prevention.According to an embodiment of the present, present a theatrical performance as the last item on a programme and 2325 can be configured to around applicator chamber 2346 at least partially.According to an embodiment of the present, present a theatrical performance as the last item on a programme and 2325 can be set up and be positioned to prevent vacuum seal from being exceeded predetermined point by compression when disposable device 2363 is attached to applicator 2320.According to an embodiment of the present, present a theatrical performance as the last item on a programme and 2325 can be set up and be positioned to prevent vacuum seal when disposable device 2363 is attached to applicator 2320 by compression more than 20 percent.According to an embodiment of the present, present a theatrical performance as the last item on a programme and 2325 can be set up and be positioned to prevent vacuum seal when disposable device 2363 is attached to applicator 2320 by compression more than 50 percent.According to an embodiment of the present, latch component 2359 can be suitable for contributing to the joint between disposable device 2363 and applicator 2320.According to an embodiment of the present, the latch component 2359 on disposable device 2363 can be the latch holder being suitable for the breech lock engaged in applicator 2320.
Fig. 6 is the sectional view of the disposable device 2363 intercepted along the E-E of Fig. 5.According to an embodiment of the present, disposable device 2363 comprises tissue boundary surface 2336, tissue cavity 2338, tissue biological's barrier 2337, applicator chamber 2346, chamber wall 2354 and vacuum ports 2342.According to an embodiment of the present, vacuum ports 2342 can be connected to vacuum loop 2341, and this vacuum loop 2341 can be connected to applicator chamber 2346 by applicator vacuum ports 2327 and be connected to vacuum pressure source (not shown) by vacuum coupling 2328.According to an embodiment of the present, chamber wall 2354 can be transparent or semitransparent to allow doctor or other user to see in tissue cavity 2338 and to confirm to organize acquisition situation.
According to an embodiment of the present, chamber wall 2354 can and tissue boundary surface 2336 is formed be similar to 5 to 20 spend between angle.According to an embodiment of the present, chamber wall 2354 can form with tissue boundary surface 2336 angle being similar to 20 degree.According to an embodiment of the present, chamber wall 2354 can be formed by hard Merlon or plastic material.According to an embodiment of the present, chamber wall 2354 can be coated with the thin layer of lubricant (being such as silicone oil, Teflon, Parylene or other suitable coating materials), so that obtain tissue.According to an embodiment of the present, tissue boundary surface 2336 can be coated with the thin layer of lubricant (being such as silicone oil, Teflon, Parylene or other suitable coating materials), so that obtain tissue.According to an embodiment of the present, be applied to tissue cavity 2338(and comprise wave guide wall 2366 and tissue boundary surface 2336) the face coat of such as silicone oil, Teflon, Parylene or other suitable coating materials contribute to easily obtaining tissue and prevent movement of tissue when obtaining described organizing.According to an embodiment of the present, wave guide wall 2366 can be formed by short at one end or by the waveguide of the direct plating of dielectric fill material.According to an embodiment of the present, the thickness of wave guide wall 2366 can be at least 5 times of the conduction skin depth of the material forming wave guide wall 2366.According to an embodiment of the present, wave guide wall 2366 can be copper-plated dielectric filler 2368.According to an embodiment of the present, the thickness of wave guide wall 2366 can preferably have the thickness of approximate 0.003 inch between approximate 0.0002 inch to 0.040 inch.According to an embodiment of the present, wave guide wall 2366 can be formed by solid conduction material.According to an embodiment of the present, wave guide wall 2366 can be formed by waveguide, and this waveguide is cut into predetermined length and is equipped with in the side relative with radiating guide hole and conducts short circuit part.According to an embodiment of the present, radiating guide 2364 can have the hole of approximate 0.62 inch × 0.31 inch.According to an embodiment of the present, dielectric filler 2368 can have the dielectric constant being selected to 5.8 GHz.According to an embodiment of the present, the temperature measured at coldplate thermocouple 2395 place can indicate the temperature of the skin surface of contiguous coldplate thermocouple 2395 below tissue biological's barrier 2337.According to an embodiment of the present, dielectric filler can have the dielectric constant of approximate 10.According to an embodiment of the present, dielectric filler 2368 should be low-loss material.According to an embodiment of the present, the length of dielectric filler 2368 can between approximate 20 to 80 millimeters, and preferably approximate be the integral multiple of the half of a waveguide wavelength under frequency-of-interest.According to an embodiment of the present, the length of dielectric filler 2368 can between approximate 20 to 80 millimeters, and are preferably approximate 28.5 millimeters and be approximate 48 millimeters for long wave lead antenna 2364 for shortwave lead antenna 2364.According to an embodiment of the present, at electrolyte one or more waveguide wavelength long that the length compared with the dielectric filler 2368 in long wave lead antenna 2364 can compare in shortwave lead antenna 2364.According to an embodiment of the present, approximate 20 millimeters of dielectric filler 2368 length in short antenna can be compared compared with the length of the dielectric filler 2368 in vast of heaven line.
Fig. 7 is the axonometric chart of antenna holder 2374 according to an embodiment of the present, and antenna holder 2374 also can be called as waveguide keeper.According to an embodiment of the present, antenna holder 2374 comprises Support Channel 2389 and antenna cavity 2377.
Fig. 8 is the sectional view of the antenna holder 2374 intercepted along the K-K of Fig. 7.According to an embodiment of the present, antenna holder 2374 comprises antenna cavity 2377 and support loop 2385.According to an embodiment of the present, support loop 2385 comprises Support Channel 2389 and coolant cavity 2360.According to an embodiment of the present, support loop 2385 can be used to transmission cooling fluid pass through antenna holder.According to an embodiment of the present, Support Channel 2389 can parallel join, thus allows cooling fluid to walk abreast each Support Channel 2389 and coolant cavity 2360 that flow through support loop 2385.According to an embodiment of the present, Support Channel 2389 can be connected in seriesly illustrated by such as refrigerant distribution pipe 2314(in the diagram) thus allow cooling fluid sequentially to flow through each Support Channel 2389 and the coolant cavity 2360 in support loop 2385.
Fig. 9 is the axonometric chart of aerial array 2355 according to an embodiment of the present and disposable device 2363.According to an embodiment of the present, aerial array 2355 can comprise antenna holder 2374 and waveguide assemblies 2358.According to an embodiment of the present, antenna holder 2374 can comprise Support Channel 2389.According to an embodiment of the present, waveguide assemblies 2358 can be positioned in antenna holder 2374 antenna cavity 2377 in form aerial array 2355.According to an embodiment of the present, waveguide assemblies 2358 can comprise one or more radiating guide 2364.According to an embodiment of the present, waveguide assemblies 2358 can comprise first wave guide antenna 2364a, Second Wave lead antenna 2364b, the 3rd radiating guide 2364c and the 4th radiating guide 2364d.According to an embodiment of the present, it can be tuning screw that waveguide assemblies 2358 can comprise multiple tuned cell 2390() and multiple feeding adapter 2388, feeding adapter 2388 can be customization erecting of panel SMA adapter.According to an embodiment of the present, each radiating guide 2364 can comprise a tuned cell 2390 and a feeding adapter 2388.According to an embodiment of the present, microwave energy can be fed to each radiating guide by interconnecting cable 2372.According to an embodiment of the present, tuned cell 2390 can comprise through wave guide wall 2366 and enter in dielectric filler 2368, formed with wave guide wall 2366 tuning screw of electrical contact.According to an embodiment of the present, tuned cell 2390 can be located in approximate 3/4 the waveguide wavelength place of rear wall (such as short-circuit component 2373) apart from radiating guide 2364.According to an embodiment of the present, the degree of depth of tuned cell 2390 can be adjusted to and radiating guide 2364 is tuned to frequency-of-interest.According to an embodiment of the present, the degree of depth of tuned cell 2390 can be adjusted to and radiating guide 2364 is tuned to the mid frequency with approximate 5.8 GHz.
Figure 10 is the sectional view of the aerial array 2355 and disposable device 2363 intercepted along the A-A of Fig. 9.According to an embodiment of the present, waveguide assemblies 2358 is positioned in the antenna cavity 2377 of antenna holder 2374.According to an embodiment of the present, waveguide assemblies 2358 comprises one or more radiating guide 2364.According to an embodiment of the present, signal can be fed in radiating guide 2364 by feeding adapter 2388, and feeding adapter 2388 can comprise antenna feed device 2370.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368, wave guide wall 2366(can be such as waveguide or conductive wall and can be more specifically WR62 waveguide), tuned cell 2390 and short-circuit component 2373(can be such as metallic gasket).According to an embodiment of the present, can by such as dielectric filler 2368 to be press-fitted in the wave guide wall 2366 be made up of waveguide and the opening brazing short-circuit component 2373 striding across waveguide manufactures radiating guide 2364.According to an embodiment of the present, disposable device 2363 can comprise tissue cavity 2338, tissue boundary surface 2336(can be such as tissue biological's barrier 2337), vacuum ports 2342 and chamber wall 2354.According to an embodiment of the present, biological barrier 2337 can be the hydrophobic membrane that such as can obtain from GE Osmotics.According to an embodiment of the present, coldplate 2340, dispersing element 2378 and separation rib 2393 can be positioned in the antenna cavity 2377 between aerial array 2355 and disposable device 2363.According to an embodiment of the present, dispersing element 2378(can be referred to as an extension device) can be the extension of such as dielectric filler 2368.According to an embodiment of the present, dispersing element 2378 can be such as absorber element.According to an embodiment of the present, dispersing element 2378 can be the absorber element of the microwave energy of the hole radiation weakened at least in part from radiating guide 2364.According to an embodiment of the present, dispersing element 2378 can be weaken at least in part from the hole radiation of radiating guide 2364, the absorber element of the microwave energy of the effective field size that increases radiating guide 2364.According to an embodiment of the present, dispersing element 2378 can be weaken at least in part from the hole radiation of radiating guide 2364, the absorber element that scatters the microwave energy of SAR pattern in tissue below radiating guide 2364.According to an embodiment of the present, antenna feed device 2370 can be the center conductor of the feeding adapter 2388 extended in the dielectric filler 2368 of radiating guide 2364.According to an embodiment of the present, antenna feed device 2370 can be positioned such that microwave signal to be delivered in radiating guide 2364 and the reflection minimized caused by the reaction coupling (producing impedance match situation in frequency-of-interest (such as 5.8 GHz)) between antenna feed device 2370 and the rear wall of radiating guide 2364 from feeding adapter 2388.According to an embodiment of the present, antenna feed device 2370 can be positioned such that microwave signal to be delivered in radiating guide and the reflection minimized caused by the reaction coupling (producing the match condition of 50 ohm at 5.8 GHz) between feeder and rear wall from feeding adapter.According to an embodiment of the present, antenna feed device 2370 can be oriented to be similar to two millimeters apart from rear wave guide wall 2366.According to an embodiment of the present, antenna feed device 2370 can be oriented to apart from approximate two millimeters of the joint between short-circuit component 2373 and waveguide.
Figure 11 is the sectional view of the aerial array 2355 and disposable device 2363 intercepted along the B-B of Fig. 9.According to an embodiment of the present, radiating guide 2364 can be positioned in the antenna cavity 2377 of antenna holder 2374.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368, wave guide wall 2366 and short-circuit component 2373.According to an embodiment of the present, antenna holder 2374 can comprise antenna cavity 2377 and Support Channel 2389.According to an embodiment of the present, disposable device 2363 can comprise tissue cavity 2338, can be the tissue boundary of such as tissue biological's barrier 2337 surface 2336 and chamber wall 2354.According to an embodiment of the present, dispersing element 2378, dispersing element 2378 and separation rib 2393 can be positioned in the antenna cavity 2377 between aerial array 2355 and disposable device 2363.
Figure 12 is the axonometric chart of aerial array 2355 according to an embodiment of the present.According to an embodiment of the present, waveguide assemblies 2358 can comprise multiple can be the tuned cell 2390 of tuning screw and multiple feeding adapter 2388.According to an embodiment of the present, microwave energy can be supplied to each radiating guide by interconnecting cable 2372.
Figure 13 is the sectional view of the aerial array 2355 intercepted along the C-C of Figure 12.According to an embodiment of the present, waveguide assemblies 2358 can be positioned in the antenna cavity 2377 of antenna holder 2374.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368, wave guide wall 2366, tuned cell 2390 and can be the short-circuit component 2373 of such as metallic gasket.According to an embodiment of the present, separation rib 2393, dispersing element 2378 and coldplate 2340 can be positioned in the far-end of aerial array 2355.
Figure 14 is the sectional view of the aerial array 2355 intercepted along the D-D of Figure 12.According to an embodiment of the present, dispersing element 2378, coldplate 2340 and separation rib 2393 can be positioned in the far-end of aerial array 2355 and disposable device 2363.
Figure 15 is the sectional view of the distal portions of the aerial array 2355 intercepted along the C-C of Figure 12.According to an embodiment of the present, waveguide assemblies 2358 comprises one or more radiating guide 2364 (a-d).According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368, wave guide wall 2366 and tuned cell 2390.According to an embodiment of the present, dispersing element 2378 and separation rib 2393 can be positioned in coolant cavity 2360.According to an embodiment of the present, coolant cavity 2360(also can be called as heat exchanger channels) cooling fluid 2361 can be comprised.
Figure 16 shows coldplate according to an embodiment of the present and thermocouple.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in coldplate groove 2394.According to an embodiment of the present, coldplate 2340, coldplate thermocouple 2395 and coldplate groove 2394 can be positioned under tissue biological's barrier 2337.
Figure 17 is the sectional view of a part for the coldplate 2340 and coldplate thermocouple 2395 intercepted along the J-J of Figure 16.Figure 18 is the sectional view of a part for the coldplate 2340 and coldplate thermocouple 2395 intercepted along the J-J of Figure 16.According to an embodiment of the present, coldplate thermocouple 2395 can be flattened to guarantee the flat surface being butted on coldplate 2340 of tissue biological's barrier 2337.According to an embodiment of the present, coldplate 2340 can be positioned at the far-end of applicator 2320.According to an embodiment of the present, coldplate 2340 can be bonded in the far-end of antenna holder 2374.According to an embodiment of the present, coldplate 2340 can be oriented to the stretch tissue biological barrier 2337 when disposable device 2363 is connected to applicator 2320.According to an embodiment of the present, coldplate 2340 can be oriented to extend to interior 0.001 inch to 0.020 inch of tissue cavity 2338 when disposable device 2363 is attached to applicator 2320, and preferably 0.010 inch.According to an embodiment of the present, can select to have the coldplate 2340 of approximate 0.010 inch of to 0.014 inch and preferably 0.014 inch thickness.According to an embodiment of the present, coldplate 2340 can be selected from the material be coupled rigidity, high-termal conductivity and dielectric constant being chosen to be increase microwave energy and tissue.According to an embodiment of the present, coldplate 2340 can be pottery.According to an embodiment of the present, coldplate 2340 can be 90% to 99% and preferably 96% aluminium oxide.According to an embodiment of the present, coldplate 2340 can to have under room temperature between approximate 1 W/ (mK) to approximate 75 W/ (mK) and the heat conductivity of preferably approximate 30 W/ (mK) (TS).According to an embodiment of the present, coldplate 2340 can to have between 4 to 15 and preferably 10 dielectric constant.According to an embodiment of the present, coldplate 2340 can be minimize the material being strapped in the microwave energy in coldplate 2340 with the form of surface wave.
According to an embodiment of the present, the distal surface of coldplate 2340 can comprise multiple thermocouple passage, such as coldplate groove 2394.According to an embodiment of the present, coldplate groove 2394 can to have between approximate 0.003 inch to 0.007 inch and the preferred degree of depth of approximate 0.005 inch.According to an embodiment of the present, coldplate groove 2394 can have the width of approximate 0.014 inch.According to an embodiment of the present, coldplate groove 2394 can be positioned such that they directly pass under the center of the hole of radiating guide 2364.According to an embodiment of the present, coldplate groove 2394 can be positioned such that coldplate thermocouple 2395 is positioned directly under the center of the hole of radiating guide 2364.According to an embodiment of the present, coldplate groove 2394 can be positioned such that they directly pass under the center of dispersing element 2378.According to an embodiment of the present, coldplate groove 2394 can be positioned such that coldplate thermocouple 2395 is located immediately under the center of dispersing element 2378.According to an embodiment of the present, coldplate groove 2394 can be positioned such that they stride across have the highest SAR obtain tissue part.According to an embodiment of the present, coldplate groove 2394 can be positioned such that coldplate thermocouple 2395 be positioned in have the highest SAR obtain on tissue part.According to an embodiment of the present, coldplate groove 2394 can be positioned such that their E-field components perpendicular to the output of radiating guide 2364.According to an embodiment of the present, coldplate groove 2394 can be positioned such that the E-field component of the electric wire of coldplate thermocouple 2395 perpendicular to the output of radiating guide 2364.According to an embodiment of the present, coldplate groove 2394 can be positioned such that sections transverse under the hole that the electric wire of coldplate thermocouple 2395 is positioned at radiating guide 2364 is in the E-field component of the output of radiating guide 2364.
According to an embodiment of the present, the proximal end face of coldplate 2340 can be oriented to the far-end contacting each dispersing element 2378.According to an embodiment of the present, coldplate 2340 can be selected to the surface of hole in the interface that has between the far-end minimizing coldplate 2340 and dispersing element 2378 or defect.According to an embodiment of the present, interface between coldplate 2340 and dispersing element 2378 can be designed to the existence of minimum material, and described material comprises when from causing the disturbance of this interface or the air of focus and cooling fluid during radiating guide 2364 launched microwave energy.According to an embodiment of the present, coldplate 2340 can be substantially flat.According to an embodiment of the present, the flatness of coldplate 2340 can be less than the surperficial change degree of approximate 0.0002 inch.According to an embodiment of the present, the such as binding agent of dielectric-epoxy resin (such as Eccosorb epoxy resin) can be used to coldplate 2340 to be attached to each dispersing element 2378.
According to an embodiment of the present, coldplate thermocouple 2395 can provide feedback to indicate the temperature of the tissue near the distal side of coldplate 2340.According to an embodiment of the present, coldplate thermocouple 2395 can provide feedback to indicate the temperature of the tissue be bonded in tissue cavity 2338.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in the coldplate groove 2394 of the distal side of coldplate 2340.According to an embodiment of the present, coldplate thermocouple 2395 can be by laser weld No. 0.39 copper and constantan make T-shaped.According to an embodiment of the present, coldplate thermocouple 2395 can be printed on the distal side of coldplate 2340.According to an embodiment of the present, coldplate thermocouple 2395 may be oriented to and makes to comprise coldplate thermocouple electric wire by coldplate thermocouple 2395(in microwave field) disturbance that causes is minimized.According to an embodiment of the present, coldplate thermocouple 2395 may be oriented to and makes coldplate thermocouple 2395(comprise coldplate thermocouple electric wire) impact of the SAR pattern of applicator 2320 is minimized.According to an embodiment of the present, coldplate thermocouple 2395 may be oriented to and makes coldplate thermocouple 2395(comprise thermocouple electric wire) impact that the damage of the tissue be engaged with in tissue cavity 2338 generates is minimized.According to an embodiment of the present, coldplate thermocouple 2395 may be oriented to the E-field that coldplate thermocouple wire is launched perpendicular to radiating guide 2364.According to an embodiment of the present, in order to minimize the disturbance of microwave field while the mechanical integrity keeping coldplate thermocouple 2395 wire, coldplate thermocouple 2395 wire to can be selected between approximate No. 30 to approximate No. 40 and preferably approximate No. 39.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in the coldplate 2340 under each radiating guide 2364 distal side on so that thermocouple weld seam is positioned at the centre of the hole of radiating guide 2364.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned under each waveguide so that thermocouple weld seam is positioned at the centre of dispersing element 2378.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in the groove on the surface of coldplate 2340, so that weld seam or thermocouple electric wire all can not extend to outside coldplate groove 2394.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in the coldplate groove 2394 on the surface of coldplate 2340, when being attached to applicator 2320 with convenient disposable bioreactor part 2363 weld seam or thermocouple electric wire all can not pushes against tissue biological barrier 2337 more than approximate 0.003 inch.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in the coldplate groove 2394 on the surface of coldplate 2340, and when being attached to applicator 2320 with convenient disposable bioreactor part 2363, thermocouple weld seam and thermocouple electric wire all can not pushes against tissue biological barriers 2337 thus produce air pocket between tissue biological's barrier 2337 and the distal side of coldplate 2340.According to an embodiment of the present, coldplate thermocouple 2395 weld seam can be flattened thus guarantee that they are fitted in coldplate groove 2394.According to an embodiment of the present, coldplate thermocouple 2395 weld seam can be flattened thus produce the weld seam with at least one approximate 0.004 inch cross-section, to guarantee that coldplate thermocouple 2395 weld seam can not extend to outside coldplate groove 2395 by approximate 0.008 inch cross-section.According to an embodiment of the present, the quantity of coldplate thermocouple 2395 can be substantially equal to the quantity of aerial array 2355 inner waveguide antenna 2364.According to an embodiment of the present, the quantity of coldplate thermocouple 2395 can be four, the corresponding coldplate thermocouple of each radiating guide 2364a-2364d in aerial array 2355.According to an embodiment of the present, coldplate thermocouple 2395 is used for providing feedback with the temperature indicating the tissue be bonded in tissue cavity 2338 to generator 2301.According to an embodiment of the present, coldplate thermocouple 2395 is used for providing feedback with the temperature indicating the tissue be positioned at below each radiating guide 2364 to generator 2301.
Figure 19 is the perspective end view of aerial array 2355, coolant cavity 2360, separation rib 2393 and dispersing element 2378 according to an embodiment of the present.According to an embodiment of the present, waveguide assemblies 2358 can comprise multiple tuned cell 2390 and multiple feeding adapter 2388.According to an embodiment of the present, Support Channel 2389 can be connected to coolant cavity 2360.
Figure 20 is the end-view of aerial array 2355, coolant cavity 2360, separation rib 2393 and dispersing element 2378 according to an embodiment of the present.According to an embodiment of the present, waveguide assemblies 2358 can comprise one or more radiating guide 2364a, 2364b, 2364c and 2364d.According to an embodiment of the present, waveguide assemblies 2358 can comprise multiple feeding adapter 2388.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368 and wave guide wall 2366.According to an embodiment of the present, Support Channel 2389 can be connected to coolant cavity 2360.According to an embodiment of the present, coolant channel 2360a can be positioned at below radiating guide 2364a.According to an embodiment of the present, coolant channel 2360b can be positioned at below radiating guide 2364b.According to an embodiment of the present, coolant channel 2360c can be positioned at below radiating guide 2364c.According to an embodiment of the present, coolant channel 2360d can be positioned at below radiating guide 2364d.According to an embodiment of the present, dispersing element 2378a can be positioned in coolant cavity 2360a.According to an embodiment of the present, dispersing element 2378b can be positioned in coolant cavity 2360b.According to an embodiment of the present, dispersing element 2378c can be positioned in coolant cavity 2360c.According to an embodiment of the present, dispersing element 2378d can be positioned in coolant cavity 2360d.According to an embodiment of the present, Support Channel 2389 can be suitable for supplying cooling fluid to coolant cavity 2360.According to an embodiment of the present, separation rib 2393 can be positioned in the either side of coolant cavity 2360a-2360d.
Figure 21 is the axonometric chart of applicator 2320 according to an embodiment of the present and disposable device 2363.According to an embodiment of the present, applicator 2320 latched mechanism 2365 can be attached to disposable device 2363.According to an embodiment of the present, applicator 2320 can comprise applicator cable 2334.According to an embodiment of the present, disposable device 2363 can comprise vacuum tube 2319, tissue cavity 2338, alignment feature 2352 and tissue boundary surface 2336.According to an embodiment of the present, alignment feature 2352 can be located in the distance contributing to the suitable placement of applicator 2320 at treatments period.According to an embodiment of the present, alignment feature 2352 can be oriented to separately approximate 30.7 millimeters.According to an embodiment of the present, alignment feature 2352 can by location, also can be designed to assist physicians locates applicator 2320 before application of the energy further.According to an embodiment of the present, the alignment feature 2352 on disposable device 2363 assist user before treatment correctly locate applicator and during operation process mobile applicator to next area for treatment.According to an embodiment of the present, when together using with the mark in area for treatment or boundary mark, the alignment feature 2352 on disposable device 2363 contributes to producing continuous damage.
Figure 22 is the end-view of the far-end of the applicator 2320 shown in Figure 21 and disposable device 2363.According to an embodiment of the present, disposable device 2363 can comprise tissue biological's barrier 2337.According to an embodiment of the present, applicator 2320 can comprise and such as can be positioned at tissue biological's barrier 2337 coldplate 2340 below.According to an embodiment of the present, tissue biological's barrier 2337 can the part of formative tissue interface surface 2336.According to an embodiment of the present, disposable device 2363 can comprise vacuum ports 2342 and vacuum passage 2350.According to an embodiment of the present, vacuum ports 2342 can be the hole that such as can directly or indirectly be connected in disposable device 2363 far-end of vacuum tube 2319 and vacuum passage 2350, and it can be formed by the groove in disposable device 2363.According to an embodiment of the present, bolt lock mechanism 2365 can be used to contribute to disposable device 2363 to be connected to applicator 2320.
Figure 23 is the exploded perspective view of the applicator 2320 shown in Figure 21 and disposable device 2363.According to an embodiment of the present, applicator 2320 can comprise coldplate 2340, separation rib 2393, antenna holder 2374, waveguide assemblies 2358 and duplexer 2357.According to an embodiment of the present, waveguide assemblies 2358 can comprise antenna 2364 (a-d).According to an embodiment of the present, disposable device 2363 can comprise vacuum tube 2319, alignment feature 2352, latch component 2359, top vacuum cover 2345 and vacuum seal 2348.According to an embodiment of the present, top vacuum cover 2345 hides and seals (Figure 27) at least partially of main vacuum passage 2335.
Figure 24 is the sectional view of the applicator 2320 shown in Figure 21 and disposable device 2363.According to an embodiment of the present, applicator 2320 can comprise aerial array 2355, duplexer 2357 and applicator cable 2334.According to an embodiment of the present, applicator cable 2334 can comprise coldplate thermocouple electric wire 2330, coolant thermocouple electric wire 2331, coolant supply pipe 2312, coolant recurrent canal 2313, duplexer signal 2481, energy cable 2322.According to an embodiment of the present, coldplate thermocouple electric wire 2330 can comprise one or more thermocouple electric wire, and described thermocouple electric wire can be attachable to one or more thermocouple with the output relative localization of aerial array 2355.According to an embodiment of the present, coolant thermocouple electric wire 2331 can comprise one or more thermocouple electric wire being attached to one or more cooling path thermocouple 2326, and described cooling path thermocouple 2326 can be oriented to measure the coolant fluid in such as coolant recurrent canal 2313.According to an embodiment of the present, one or more cooling path thermocouple 2326 can be oriented to measure cooling fluid 2361 and flow through temperature after coolant cavity 2360.According to an embodiment of the present, one or more cooling path thermocouple 2326 can be positioned at coolant recurrent canal 2313.According to an embodiment of the present, cooling path thermocouple 2326 is used for providing feedback to flow through temperature after coolant cavity 2360 to indicate cooling fluid 2361 to generator 2301.According to an embodiment of the present, disposable device 2363 can comprise latch component 2359.
Figure 25 is the view of the far-end of disposable device 2363 according to an embodiment of the present.According to an embodiment of the present, disposable device 2363 can comprise tissue boundary surface 2336, tissue cavity 2338 and alignment feature 2352.According to an embodiment of the present, tissue boundary surface 2336 can the rear wall in formative tissue chamber 2338.According to an embodiment of the present, tissue boundary surface 2336 can comprise tissue biological's barrier 2337, vacuum passage 2350 and vacuum ports 2342.According to an embodiment of the present, disposable device 2363 comprises alignment feature 2352 and vacuum tube 2319.
Figure 26 is the view of the proximal lateral of the disposable device 2363 shown in Figure 25.According to an embodiment of the present, disposable device 2363 comprises applicator chamber 2346.According to an embodiment of the present, applicator chamber can comprise the applicator chamber 2346 that can be formed by tissue biological's barrier 2337 at least in part.According to an embodiment of the present, disposable device 2363 comprises alignment feature 2352 and vacuum tube 2319.According to an embodiment of the present, disposable device 2363 can comprise top vacuum cover 2345.
Figure 27 is the view of the first paragraph of the proximal lateral of the disposable device 2363 shown in Figure 26, wherein eliminates top vacuum cover 2345.According to an embodiment of the present, disposable device 2363 can comprise applicator chamber 2346(and can comprise tissue biological's barrier 2337), side vacuum cover 2347 and vacuum seal 2348.According to an embodiment of the present, side vacuum cover 2347 hides and seals main vacuum passage 2335 at least partially.According to an embodiment of the present, disposable device 2363 can comprise applicator biological barrier 2332(can be the polyethylene film that such as can obtain from Fisher Scientific) (TS), vacuum passage 2333 and vacuum barrier 2343.According to an embodiment of the present, vacuum coupling 2328 can be connected to the vacuum ports 2342 in tissue cavity 2338 and be connected to applicator biological barrier 2332 by vacuum passage 2333.According to an embodiment of the present, vacuum passage 2333 forms the indirect or roundabout of directapath and the arrival applicator biological barrier 2332 arriving tissue boundary surface 2336.According to an embodiment of the present, vacuum passage 2333 can be suitable for retraining the fluid motion flowing to applicator biological barrier 2332 from tissue cavity 2338.According to an embodiment of the present, vacuum coupling 2328 can be positioned in the side relative with applicator biological barrier 2332 of disposable device 2363, to advance for air when a vacuum is applied produce long circuitous path.According to an embodiment of the present, can be designed such that more to be difficult to fluid to draw from tissue cavity 2338 towards applicator biological barrier 2332 from vacuum coupling 2328 to the indirect path of applicator biological barrier 2332, particularly when there is back pressure in vacuum passage 2333, such as by opening the vacuum spiral spool 2315 between the vacuum pump/driver 2307 in disposable device 2363 and generator, or by tissue be pulled leave tissue boundary surface 2336 time tissue cavity 2338 in generation vacuum and cause described back pressure.According to an embodiment of the present, vacuum pump 2450 and vacuum spiral spool 2315 can be used to supporting tissue and obtain applicator 2320.According to an embodiment of the present, main vacuum passage 2335 can extend to vacuum passage 2333 and applicator biological barrier 2332 from vacuum coupling 2328.According to an embodiment of the present, main vacuum passage 2335 can be connected to the vacuum ports 2342 in tissue boundary surface 2336 by vacuum passage 2333.According to an embodiment of the present, vacuum barrier 2343 can be positioned in the main vacuum passage 2335 between vacuum passage 2333 and applicator biological barrier 2332.According to an embodiment of the present, vacuum barrier 2343 can be suitable for helping by the air pressure in applicator chamber 2346 and tissue cavity 2338 during providing the pressure drop between vacuum passage 2333 and applicator biological barrier 2332 to keep tissue acquisition substantially equal.According to an embodiment of the present, vacuum barrier 2343 can be oriented to and be suitable for helping obtaining the pressure between the greater amount air between skin stage in balanced applicator chamber 2346 and tissue cavity 2338.According to an embodiment of the present, vacuum barrier 2343 can be suitable for the amount retraining the return pressure arriving applicator biological barrier 2332.According to an embodiment of the present, vacuum barrier 2343 can be suitable for retraining when applying return pressure (such as appropriately turn off after vacuum or skin be pushed out tissue cavity 2338 or leave tissue boundary surperficial 2336 time) arrive the amount of the biofluid of applicator biological barrier 2332.According to an embodiment of the present, vacuum barrier 2343 can be oriented to and be suitable for producing pressure drop enter tissue cavity 2338 to make the major part of any return pressure be released by vacuum passage 2333.According to an embodiment of the present, vacuum barrier 2343 can be suitable for providing mechanical obstacles in the circuitous path of vacuum loop 2341, which increases the pressure of the side of vacuum barrier 2343 when air flows through main vacuum passage 2335.According to an embodiment of the present, baffle plate can be suitable for providing mechanical obstacles with increase air pass through main vacuum passage 2335 time circuitous path length.According to an embodiment of the present, applicator biological barrier 2332 can be positioned between vacuum passage 2333 and applicator chamber 2346.According to an embodiment of the present, applicator biological barrier 2332 can be can be suitable for through air but substantially not through the film of the biofluid of such as blood and antiperspirant.According to an embodiment of the present, applicator biological barrier 2332 can be hydrophobic membrane filter.According to an embodiment of the present, applicator biological barrier 2332 can be made up of polyethylene film nylon or other suitable materials.According to an embodiment of the present, applicator biological barrier 2332 can comprise hole, and the size in described hole is enough to make enough air by biofluid being made to pass through with balanced vacuum.According to an embodiment of the present, applicator biological barrier 2332 can comprise the hole with approximate 0.45 micron-scale.According to an embodiment of the present, when vacuum is switched on and before pressure is by equilibrium, applicator biological barrier 2332 can cause minimum pressure drop between vacuum passage 2333 and applicator chamber 2346.
Figure 28 is the view of the second segment of the proximal lateral of the disposable device 2363 shown in Figure 26, wherein eliminates top vacuum cover 2345.According to an embodiment of the present, disposable device 2363 can comprise applicator chamber 2346(and can comprise tissue biological's barrier 2337) and vacuum seal 2348.According to an embodiment of the present, disposable device 2363 can comprise vacuum passage 2333 and vacuum coupling 2328.According to an embodiment of the present, vacuum passage 2333 can be connected to vacuum tube 2319 by vacuum coupling 2328.
Figure 29 is the sectional view of the disposable device 2363 intercepted along the H-H of Figure 25.According to an embodiment of the present, disposable device 2363 comprises applicator chamber 2346 and tissue cavity 2338.According to an embodiment of the present, applicator chamber 2346 and tissue cavity 2338 can at least in part by tissue biological's barrier 2337 separately.According to an embodiment of the present, tissue cavity 2338 can comprise tissue boundary surface 2336 and chamber wall 2354.According to an embodiment of the present, tissue boundary surface 2336 can be formed by tissue biological's barrier 2337 at least in part.According to an embodiment of the present, disposable device 2363 can comprise vacuum loop 2341.According to an embodiment of the present, vacuum loop 2341 can comprise vacuum tube 2319, vacuum coupling 2328, vacuum barrier 2343, vacuum passage 2333 and applicator biological barrier 2332.According to an embodiment of the present, tissue cavity 2338 can be connected to vacuum tube 2319 by vacuum passage 2333 by vacuum loop 2341.According to an embodiment of the present, applicator chamber 2346 can be connected to vacuum tube 2319 by applicator biological barrier 2332 by vacuum loop 2341.According to an embodiment of the present, disposable device 2363 can comprise top vacuum cover 2345 and side vacuum cover 2347.According to an embodiment of the present, top vacuum cover 2345 and side vacuum cover 2347 can sealed vacuum loops 2341.
Figure 30 is the view of a section of the disposable device 2363 shown in Figure 30.According to an embodiment of the present, disposable device 2363 comprises applicator chamber 2346 and tissue cavity 2338.According to an embodiment of the present, applicator chamber 2346 and tissue cavity 2338 can at least in part by tissue biological's barrier 2337 separately.According to an embodiment of the present, tissue cavity 2338 can comprise tissue boundary surface 2336 and chamber wall 2354.According to an embodiment of the present, tissue boundary surface 2336 can be formed by tissue biological's barrier 2337 at least in part.According to an embodiment of the present, disposable device 2363 can comprise vacuum loop 2341.According to an embodiment of the present, vacuum loop 2341 can comprise vacuum barrier 2343, vacuum passage 2333 and applicator biological barrier 2332.According to an embodiment of the present, vacuum loop 2341 can be connected to tissue cavity 2338 by vacuum passage 2333.According to an embodiment of the present, applicator chamber 2346 can be connected to vacuum loop 2341 by applicator biological barrier 2332 by vacuum loop 2341.According to an embodiment of the present, disposable device 2363 can comprise top vacuum cover 2345 and side vacuum cover 2347.
Figure 30 A is the view of a section of alternate embodiments according to the present invention disposable device 2363 shown in Figure 29.Figure 30 B is the view of a section of alternate embodiments according to the present invention disposable device 2363 shown in Figure 29.According to an embodiment of the present, chamber wall 2354 can comprise compliant member (compliant member) 2375.According to an embodiment of the present, compliant member 2375 can be formed by flexible material, and this flexible material is such as rubber, (with soft plastics or rubber seal coating) coating potassamide acid esters foam, silicones, polyurethane or heat-sealing open celled foam.According to an embodiment of the present, compliant member 2375 can be positioned in tissue cavity 2338 outward flange around to contribute to obtaining tissue.According to an embodiment of the present, compliant member 2375 can be oriented to organize around the outward flange of chamber opening 2339 to contribute to obtaining.According to an embodiment of the present, compliant member 2375 can contribute to engaging uneven tissue, such as, tissue in axillary fossa.According to an embodiment of the present, compliant member 2375 can contribute to engaging uneven tissue, such as, tissue in the exterior lateral area of axillary fossa.According to an embodiment of the present, compliant member 2375 between skin and tissue cavity 2338, particularly at skin injustice place, can provide the sealing characteristics of improvement.According to an embodiment of the present, compliant member 2375 can accelerate to obtain tissue in tissue cavity 2338, particularly skin injustice place.According to an embodiment of the present, when compliant member 2375 can not had the height between approximate 0.15 inch to approximate 0.40 inch by compliant member 2375 during compression above chamber opening 2339.According to an embodiment of the present, when compliant member 2375 can not had the height of approximate 0.25 inch above chamber opening 2339 by compliant member 2375 during compression.
Figure 31 is the axonometric chart of antenna holder 2374 according to an embodiment of the present.According to an embodiment of the present, antenna holder 2374 can comprise antenna cavity 2377 and support loop 2385.According to an embodiment of the present, support loop 2385 can be adapted so that cooling fluid cycles through antenna holder 2374.According to an embodiment of the present, support loop 2385 can comprise at least one support storage tank 2387.According to an embodiment of the present, support loop 2385 can include an inlet and an outlet support storage tank 2387.
Figure 32 is the three-dimensional cutaway view of the antenna holder 2374 along the F-F intercepting in Figure 31.According to an embodiment of the present, antenna holder 2374 can comprise antenna cavity 2377 and support loop 2385.According to an embodiment of the present, support loop 2385 can be adapted so that cooling fluid cycles through the antenna holder 2374 as part cooling fluid path 2381.According to an embodiment of the present, cooling fluid path 2381 can be a part for cooling circuit 2376.According to an embodiment of the present, support loop 2385 can include an inlet and an outlet support storage tank 2387 and Support Channel 2389.According to an embodiment of the present, the element in support loop 2385 and cooling fluid path 2381 can be designed to contribute to fluid and steadily flows through support loop 2385 and cooling fluid path 2381.According to an embodiment of the present, support loop 2385 can become fillet with the element in cooling fluid path 2381 and be leveled sliding steadily to flow through support loop 2385 and cooling fluid path 2381 to contribute to fluid.
Figure 33 is the sectional view of the antenna holder 2374 intercepted along the F-F of Figure 31.According to an embodiment of the present, support loop 2385 can be adapted so that cooling fluid cycles through the antenna holder 2374 as part cooling fluid path 2381.According to an embodiment of the present, cooling fluid path 2381 can comprise support loop 2385 and coolant cavity 2360.According to an embodiment of the present, coolant cavity 2360 can be formed by far-end coldplate 2340 being fixed on antenna holder 2374.According to an embodiment of the present, can by such as coldplate 2340 being bonded to antenna holder 2374 and coldplate 2340 being fixed on antenna holder 2374.According to an embodiment of the present, cooling fluid path 2381 can be a part for cooling circuit 2376.According to an embodiment of the present, support loop 2385 can comprise support storage tank 2387 and Support Channel 2389.According to an embodiment of the present, the element in support loop 2385 and cooling fluid path 2381 can be designed to contribute to fluid and steadily flows through support loop 2385 and cooling fluid path 2381.According to an embodiment of the present, support loop 2385 can become fillet with the element in cooling fluid path 2381 and be leveled sliding steadily to flow through support loop 2385 and cooling fluid path 2381 to contribute to fluid.
Figure 34 is the three-dimensional cutaway view of a section of the antenna holder 2374 intercepted along the I-I of Figure 31.According to an embodiment of the present, antenna holder 2374 can comprise support loop 2385.According to an embodiment of the present, support loop 2385 can comprise support storage tank 2387 and Support Channel 2389.
Figure 35 is the axonometric chart of aerial array 2355 according to an embodiment of the present.According to an embodiment of the present, antenna holder 2374 can comprise storage tank entrance 2384 and antenna cavity 2377.According to an embodiment of the present, waveguide assemblies 2358 can comprise one or more isolated component 2391(between radiating guide 2364 can be such as the ECCOSORB MF-190 microwave absorbing material that can obtain from Emerson & Cuming Microwave Products).According to an embodiment of the present, microwave energy can be provided to each radiating guide by feeding adapter 2388.According to an embodiment of the present, waveguide assemblies 2358 can be kept together by waveguide assemblies framework 2353.According to an embodiment of the present, waveguide assemblies framework 2353 can comprise feeding bracket 2351 and assembly bolt 2349.According to an embodiment of the present, aerial array 2355 can comprise antenna holder and at least one radiating guide 2364.According to an embodiment of the present, aerial array 2355 can comprise one or more isolated component 2391.According to an embodiment of the present, aerial array 2355 can comprise four radiating guides 2364.According to an embodiment of the present, the height of the radiating guide 2364 in aerial array 2355 can be staggered to contribute to sensible feeding adapter 2388.
Figure 36 is the sectional view of the aerial array 2355 intercepted along the L-L of Figure 35.According to an embodiment of the present, waveguide assemblies 2358 comprises one or more radiating guide 2364, one or more feeding bracket 2351 and one or more isolated component 2391.According to an embodiment of the present, waveguide assemblies 2358 comprises radiating guide 2364a, 2364b, 2364c and 2364d.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368, wave guide wall 2366 and tuned cell 2390.According to an embodiment of the present, radiating guide 2364 can be manufactured by using suitable coating material plating dielectric filler 2368 such as such as copper, gold, silver etc.According to an embodiment of the present, such as, by plating or plating dielectric fill material, dielectric filler 2368, wave guide wall 2366 can be formed.According to an embodiment of the present, by direct plating or plating dielectric fill material, all except radiation hole can be covered, form wave guide wall 2366.According to an embodiment of the present, copper can be preferred coating material.According to an embodiment of the present, dispersing element 2378 also can be individual component.According to an embodiment of the present, dispersing element 2378 also can be the individual component such as formed by Merlon or aluminium oxide.According to an embodiment of the present, dispersing element 2378 also can be the individual component being positioned at coolant cavity 2360.According to an embodiment of the present, dispersing element 2378 also can be positioned at coolant cavity 2360 and at the hole of radiating guide 2363 individual component placed in the middle.
Figure 37 is the view of the first paragraph of the sectional view of the aerial array 2355 shown in Figure 36.According to an embodiment of the present, waveguide assemblies 2358 can comprise one or more radiating guide 2364 (a-d) and one or more isolated component 2391.According to an embodiment of the present, isolated component 2391 can be positioned between the either side of radiating guide 2364 and waveguide assemblies 2358.According to an embodiment of the present, coolant cavity 2360(also can be called as heat exchanger channels) can be suitable for receiving cooling fluid (not shown).
Figure 38 is the axonometric chart of the second segment of the sectional view of aerial array 2335 shown in Figure 36.According to an embodiment of the present, waveguide assemblies 2358 can comprise one or more radiating guide 2364 (b-d) and one or more isolated component 2391.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368 and wave guide wall 2366.According to an embodiment of the present, coolant cavity 2360(also can be called as heat exchanger channels) can be suitable for receiving cooling fluid (not shown).
Figure 39 is the view of the 3rd section of the sectional view of the aerial array 2355 shown in Figure 36.According to an embodiment of the present, coolant cavity 2360(also can be called as heat exchanger channels) can be suitable for receiving cooling fluid (not shown).According to an embodiment of the present, separation rib 2393 can be supported by rib keeper 2396.According to an embodiment of the present, dispersing element 2378 can be designed, locates and be sized to the power loss density pattern that produces of tissue or SAR pattern of propagating joint tissue cavity 2388 in.According to an embodiment of the present, dispersing element 2378 can be formed by the material identical with dielectric filler 2368.According to an embodiment of the present, dispersing element 2378 can be the lower loss material of the dielectric constant with approximate 10.According to an embodiment of the present, dispersing element 2378 can be the lower loss material of the dielectric constant with the dielectric constant being approximately equal to implant material 2368.According to an embodiment of the present, dispersing element 2378 preferably has the dielectric constant different from the dielectric constant of cooling fluid.According to an embodiment of the present, dispersing element 2378 is preferably low-loss, the energy launched from the hole of radiating guide 2364 so that it can not weaken or dissipate.According to an embodiment of the present, the loss that dispersing element 2378 has can be less than approximate 1 in frequency-of-interest (such as 5.8 GHz).According to an embodiment of the present, for the dispersing element 2378 with low-loss cooling fluid, it preferably can have the dispersing element of higher consume so that extremely efficient field size (EFS), and this effective field size can be defined as the ratio between percent in destination organization cross section 50 SAR profile and the radiation hole of antenna.According to an embodiment of the present, dispersing element 2378 can be formed by aluminium oxide or Eccostock material.According to an embodiment of the present, dispersing element 2378 can be shaped as and contribute to the laminar flow of coolant around dispersing element 2378.According to an embodiment of the present, dispersing element 2378 can be shaped as the generation of the bubble of minimum stream in the coolant of cooling chamber 2360.According to an embodiment of the present, dispersing element 2378 can be formed and be positioned to cooling and the microwave property of optimization system.According to an embodiment of the present, dispersing element 2378 can be formed and be positioned to minimize the area of the coldplate that dispersing element 2378 covers.According to an embodiment of the present, dispersing element 2378 can be formed and be positioned to maximize the cross-sectional area that the in-house target depth engaged in tissue cavity 2338 is in the peak value SAR in target area.
According to an embodiment of the present, dispersing element 2378 can be positioned at the center of the hole of radiating guide 2364.According to an embodiment of the present, dispersing element 2378 can be rectangle, has the size proportional with the size of the hole of radiating guide 2364.According to an embodiment of the present, dispersing element 2378 can be oval.According to an embodiment of the present, dispersing element 2378 can be track type, and the elongate sides of this track type is parallel to the longest edge of the hole of radiating guide 2364.According to an embodiment of the present, dispersing element 2378 can have the length between approximate 1 millimeter to approximate 7 millimeters.According to an embodiment of the present, dispersing element 2378 can have the approximate length grown the same as the long limit of the hole of radiating guide 2364.According to an embodiment of the present, dispersing element 2378 can have the width be similar between 1 millimeter to approximate 4 millimeters.According to an embodiment of the present, dispersing element 2378 can have the approximate width grown the same as the minor face of the hole of radiating guide 2364.According to an embodiment of the present, dispersing element 2378 can have the height of approximate half millimeter.According to an embodiment of the present, dispersing element 2378 can have the height of the degree of depth being approximately equal to coolant cavity 2360.According to an embodiment of the present, dispersing element 2378 can have the area proportional with the area of the hole of radiating guide 2364.
According to an embodiment of the present, dispersing element 2378 can be positioned between the dielectric filler 2368 of radiating guide 2364 and the proximal lateral of coldplate 2340.According to an embodiment of the present, dispersing element 2378 can be oriented to both the proximal end face contacting dielectric filler 2368 and coldplate 2340.According to an embodiment of the present, dispersing element 2378 can be oriented to the air gap of the joint minimizing or eliminate between dispersing element 2378 and coldplate 2340 or the mode of other discontinuities against coldplate 2340.According to an embodiment of the present, dispersing element 2378 can such as use dielectric-epoxy resin to be attached to coldplate.According to an embodiment of the present, dispersing element 2378 can be positioned such that the field that radiating guide 2364 produces can not be assembled again when propagating through coldplate 2340.According to an embodiment of the present, dispersing element 2378 can be positioned in the center of coolant cavity 2360, and every side of dispersing element 2378 has equal flow path.According to an embodiment of the present, dispersing element 2378 may be oriented to and the longest dimension of dispersing element 2378 is alignd along the path of cooling fluid by coolant cavity 2360.According to an embodiment of the present, dispersing element 2378 can be positioned in the center in the maximum E-field intensity region that radiating guide 2364 is launched.
Figure 40 is the end-view of aerial array 2355, coolant cavity 2360, separation rib 2393 and dispersing element 2378 according to an embodiment of the present.According to an embodiment of the present, coolant channel 2360c can be positioned at the below of radiating guide 2364c.
According to an embodiment of the present, cooling circuit 2376 can comprise cooling fluid 2361, coolant conduit 2324, cooling fluid path 2381, coolant supply pipe 2312, coolant recurrent canal 2313 and refrigerant distribution pipe 2314.According to an embodiment of the present, cooling fluid path 2381 can comprise support loop 2385, coldplate 2340 and coolant cavity 2360.According to an embodiment of the present, cooling fluid path 2381 can comprise support loop 2385, coldplate 2340, coolant cavity 2360 and refrigerant distribution pipe 2314.According to an embodiment of the present, refrigerant distribution pipe 2314 is used to the continuous-flow that provides by support loop 2385 and coolant cavity 2360.According to an embodiment of the present, cooling fluid 2361 can comprise water, deionized water or other appropriate fluid.According to an embodiment of the present, cooling fluid 2361 cycles through applicator 2320 from the coolant source 2310 of applicator 2320 outside and returns coolant source 2310.According to an embodiment of the present, cooling fluid 2361 can enter cooling fluid path 2381 by coolant supply pipe 2312 and leave cooling fluid path 2381 by coolant recurrent canal 2313.According to an embodiment of the present, coolant recurrent canal 2313 can comprise thermocouple, such as cooling path thermocouple 2326, measures the temperature of the cooling fluid 2361 leaving cooling circuit 2376.According to an embodiment of the present, water-stop binding agent can be used the component in place in cooling fluid path 2381.According to an embodiment of the present, the binding agent with low water absorbable can be used the component in place in cooling fluid path 2381.According to an embodiment of the present, epoxy resin, (obtaining from TraCon) Tri-Bond FDA-16 or UV curable adhesive can be used the component in place in cooling fluid path 2381.According to an embodiment of the present, curved surface and rounded edges can for reducing or eliminating turbulent flow in whole coolant fluid path 2381.According to an embodiment of the present, curved surface and rounded edges can for reducing or eliminating bubble in whole coolant fluid path 2381.According to an embodiment of the present, hydrophilic coating may be used in cooling fluid path 2381 selected surface on to reduce or eliminate turbulent flow.According to an embodiment of the present, hydrophilic coating may be used in cooling fluid path 2381 selected surface on to reduce or eliminate bubble.According to an embodiment of the present, support loop 2385 comprises the path that cooling fluid 2361 is conveyed through antenna holder 2374.According to an embodiment of the present, support loop 2385 can be configured to serial loop or parallel circuits.According to an embodiment of the present, all or part of of support loop 2385 can be coated with water wetted material to contribute to the mild flowing of coolant and to minimize the generation of bubble, particularly in coolant cavity 2360.According to an embodiment of the present, such as when cooling fluid 2361 is parallel flow through coolant cavity 2360, support loop 2385 can comprise support storage tank 2387, comprises feed tray storage tank 2387 and returns support storage tank 2387.According to an embodiment of the present, support storage tank 2387 can be used as fluid and hold reservoir (fluidic capacitor), thus makes the flowing of the cooling fluid 2361 between coolant supply pipe 2312 and coolant cavity 2360 mild.According to an embodiment of the present, support storage tank 2387 can keep the enough cool stream scale of construction substantially impartial to guarantee the pressure striding across all coolant cavity 2360.According to an embodiment of the present, support storage tank 2387 can keep the enough cool stream scale of construction substantially impartial to guarantee the flow rate striding across all coolant cavity 2360.According to an embodiment of the present, the volume of support storage tank 2387 can be selected to the pressure that equilibrium strides across Support Channel 2389.According to an embodiment of the present, the volume of support storage tank 2387 can be selected to the flow rate that equilibrium strides across Support Channel 2389.According to an embodiment of the present, return support storage tank 2387 and can be designed to have the balanced pressure striding across Support Channel 2389 of equidistant Support Channel 2389.According to an embodiment of the present, wherein cooling fluid 2361 flows through each cooling chamber 2360 serially, by the flowing in support loop 2385, each Support Channel 2389 is directly connected to cooling chamber 2360 and has at the opposite side of cooling chamber 2360 and returns Support Channel 2389.According to an embodiment of the present, entrance with return the Support Channel agent distributing pipe 2314 that is cooled and be connected.According to an embodiment of the present, wherein cooling fluid 2361 parallel flow is through each cooling chamber 2360, and Support Channel 2389 extends to coolant cavity 2360 by parallel for support storage tank 2387.According to an embodiment of the present, the size of Support Channel 2389, shape and position are selected to and guarantee that by the flow rate of each coolant cavity be equal.According to an embodiment of the present, for all Support Channel 2389, the size and dimension of Support Channel 2389 can be identical.According to an embodiment of the present, the input of Support Channel 2389 spaced at equal intervals can stride across the bottom of support storage tank 2387.According to an embodiment of the present, the size of Support Channel 2389, shape and position can be selected to turbulent flow in minimum cryogen chamber 2360 and bubble.According to an embodiment of the present, from support storage tank 2387 to the input of Support Channel 2389.According to an embodiment of the present, Support Channel 2389 support storage tank 2387 and to coolant cavity 2360 input between the cross section of a section can be formed as wineglass or nozzle shape and the input of leading to coolant cavity 2360 is opened up into the width of coolant cavity 2360.According to an embodiment of the present, the relative cross-sectional of Support Channel 2389 can be formed as having smooth wall.According to an embodiment of the present, can rounding to the transition of coolant cavity 2360 from Support Channel 2389.According to an embodiment of the present, coolant cavity 2360 can comprise separation rib 2393.According to an embodiment of the present, the cooling fluid flowing through coolant cavity 2360 can to have between 200 ml/min to 450 ml/min and the flow rate (TS) of preferably 430 ml/min.According to an embodiment of the present, coolant cavity 2360 can be designed to guarantee that the flow rate flowing through each coolant cavity 2360 is substantially identical.According to an embodiment of the present, the cooling fluid flowing through coolant cavity 2360 can to have between 8 degrees Celsius to 22 degrees Celsius and the preferred temperature of approximate 15 degrees Celsius.According to an embodiment of the present, coolant cavity 2360 can be positioned between the hole of radiating guide 2364 and coldplate 2340.According to an embodiment of the present, dispersing element 2378 can extend to coolant cavity 2360 at least partially in.According to an embodiment of the present, dispersing element 2378 can extend through coolant cavity 2360.According to an embodiment of the present, the element of coolant cavity 2360 can be leveled sliding with the Laminar Flow promoted through the fluid of coolant cavity 2360.According to an embodiment of the present, the element of coolant cavity 2360 can be leveled sliding with the generation reducing bubble in coolant cavity 2360.According to an embodiment of the present, extend to dispersing element in coolant cavity 2360 can rounded angle to promote laminar flow and to prevent the generation of bubble in coolant cavity 2360.According to an embodiment of the present, the right-angle side in coolant cavity 2360 or wedge angle can cause having undesirable flow behavior when cooling fluid moves across coolant cavity 2360, comprise generation bubble.According to an embodiment of the present, separation rib 2393 can be used to separate each coolant cavity 2360.According to an embodiment of the present, separation rib 2393 can be configured to guarantee that each coolant cavity 2360 all has substantially identical cross section.According to an embodiment of the present, separation rib 2393 can have square cross section and be the size of approximate 0.030 inch × 0.030 inch.According to an embodiment of the present, greater or lesser separation rib 2393 can be used to guarantee that the cross-sectional area of each coolant cavity 2360 is equal.According to an embodiment of the present, separation rib 2393 can be positioned such that the arbitrary portion of their not contact cooling plate or radiating guides 2364.According to an embodiment of the present, separation rib 2393 can be positioned such that they contribute to the cooling that equilibrium strides across coldplate 2340.According to an embodiment of the present, separation rib 2393 can be sized to the width of the separation distance between the hole they be equal to or less than with radiating guide 2364.According to an embodiment of the present, separation rib 2393 can be dimensioned and be located so that they are not positioned at the hole of radiating guide 2364.According to an embodiment of the present, separation rib 2393 can be dimensioned and be located so that they minimize when pass through coolant cavity 2360 time microwave field disturbance.According to an embodiment of the present, separation rib 2393 can be dimensioned and be located so that they minimize when pass through coolant cavity 2360 time microwave field interruption.According to an embodiment of the present, can by separation rib 2393 being placed on tab-delimited rib 2393 in the rib keeper 2396 at coolant cavity 2360 either end place.According to an embodiment of the present, separation rib 2393 can be positioned such that they do not contact dispersing element 2378.According to an embodiment of the present, separation rib 2393 can be positioned in the suitable distance of proximal end face one apart from coldplate 2340 and preferably be similar to the distance of 0.010 inch in the proximal end face of distance coldplate 2340.According to an embodiment of the present, separation rib 2393 can be made up of the material of the interruption or disturbance that minimize microwave field.According to an embodiment of the present, separation rib 2393 can be made up of material that can not decaying (decline) or weaken cooling fluid.According to an embodiment of the present, separation rib 2393 can be made up of makrolon material.According to an embodiment of the present, separation rib 2393 can be made up of the material of the isolation increased between radiating guide.According to an embodiment of the present, separation rib 2393 can be made up of the material of the SAR pattern improved in tissue.According to an embodiment of the present, separation rib 2393 can be made up of Eccosorb.According to an embodiment of the present, separation rib 2393 can be made up of Eccosorb and coated to prevent separation rib 2393 to decay cooling fluid.
Figure 41 is the axonometric chart of waveguide assemblies 2358 according to an embodiment of the present.According to an embodiment of the present, waveguide assemblies 2358 can comprise one or more isolated component 2391 between radiating guide 2364a to 2364d.According to an embodiment of the present, waveguide assemblies 2358 can comprise multiple tuned cell 2390 and multiple feeding adapter 2388.According to an embodiment of the present, microwave energy can be supplied to each radiating guide by feeding adapter 2388.According to an embodiment of the present, waveguide assemblies 2358 can be kept together by waveguide assemblies framework 2353.According to an embodiment of the present, waveguide assemblies framework 2353 can comprise feeding bracket 2351 and assembly bolt 2349.
Figure 42 is the side view of the waveguide assemblies shown in Figure 41.According to an embodiment of the present, dispersing element 2378 is positioned in the output of radiating guide 2364.According to an embodiment of the present, the output of radiating guide 2364 also can be called as the hole of antenna 2364.According to an embodiment of the present, dispersing element 2378a can be positioned in the output of radiating guide 2364a.According to an embodiment of the present, dispersing element 2378b can be positioned in the output of radiating guide 2364b.According to an embodiment of the present, dispersing element 2378c can be positioned in the output of radiating guide 2364c.According to an embodiment of the present, dispersing element 2378d is to be positioned in the output of radiating guide 2364d.
Figure 43 is the sectional view intercepted along the G-G of the waveguide assemblies 2358 shown in Figure 41 and dispersing element 2378.According to an embodiment of the present, waveguide assemblies 2358 comprises one or more radiating guide 2364, one or more feeding bracket 2351 and one or more isolated component 2391.According to an embodiment of the present, waveguide assemblies 2358 comprises radiating guide 2364.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368, wave guide wall 2366 and tuned cell 2390.According to an embodiment of the present, radiating guide 2364 can be manufactured by using suitable coating material plating dielectric filler 2369.According to an embodiment of the present, feeding pad 2397 can be used to make feeding adapter 2388 matched waveguide antenna 2364 when wave guide wall 2366 is plated on dielectric filler 2368, thus guarantees the suitable contact between central insulator 2398 and dielectric filler 2368.
Figure 44 is the view of a section of the sectional view of the waveguide assemblies 2358 shown in Figure 43.According to an embodiment of the present, waveguide assemblies 2358 comprises one or more radiating guide 2364, one or more feeding bracket 2351 and one or more isolated component 2391.According to an embodiment of the present, waveguide assemblies 2358 comprises radiating guide 2364.According to an embodiment of the present, radiating guide 2364 can comprise dielectric filler 2368, wave guide wall 2366 and tuned cell 2390.According to an embodiment of the present, feeding pad 2397 can be used to make feeding adapter 2388 matched waveguide antenna 2364 when wave guide wall 2366 is plated on dielectric filler 2368, thus guarantees the suitable contact between central insulator 2398 and dielectric filler 2368.
According to an embodiment of the present, isolated component 2391 can be designed to the interaction isolated between radiating guide 2364 and balance the loading condition that inner waveguide antenna (such as radiating guide 2364a and 2364d) and outer radiating guide (such as radiating guide 2364b and 2364c) run into.According to an embodiment of the present, isolated component 2391 can absorb the part not being coupled to the in-house microwave energy that tissue cavity 2338 engages.According to an embodiment of the present, the fringing field that the metal edge place that isolated component 2391 can be absorbed in the hole of radiating guide 2364 exists.According to an embodiment of the present, isolated component 2391 can be designed and be positioned to guarantee that each radiating guide 2364 all has identical load characteristic in every side of radiating guide 2364.
According to an embodiment of the present, such as embodiment illustrated in fig. 13, the width being machined to the conductive material (such as wave guide wall 2366) guaranteed between the dielectric filler 2368 of adjacent waveguide antenna 2364 when the outer conductive wall of radiating guide 2364 for all radiating guides 2364 homogeneous phase in aerial array 2355 simultaneously, then can save the demand for isolated component 2391.According to an embodiment of the present, the wave guide wall 2366 of outer radiating guide 2364a and 2364d can be machined to and make the distance in such wave guide wall 2366 and aerial array 2355 between adjacent waveguide antenna 2364 equally thick.According to an embodiment of the present, radiating guide 2364 can be all equal by the thickness of the wave guide wall 2366 be configured so that subtly on all sides, thus save the demand for isolated component 2391.
According to an embodiment of the present, isolated component 2391 can be positioned between antenna and the outside of outer radiating guide 2364a and 2364d in aerial array 2355 thus isolation radiating guide 2364.According to an embodiment of the present, isolated component 2391 can be oriented to provide symmetrical microwave pad condition for all radiating guides 2364 in aerial array 2355.According to an embodiment of the present, isolated component 2391 can be made up of the material of microwave energy absorbing.According to an embodiment of the present, isolated component 2391 can be made up of Eccosorb.According to an embodiment of the present, the isolated component 2391 playing attenuation can be terminated to cooling fluid.
According to an embodiment of the present, isolated component 2391 can be designed and the load that runs into of the interaction being positioned to minimize between adjacent waveguide antenna 2364 and equilibrium phase adjacent wave lead antenna 2364.If radiating guide is too close together, then the SAR pattern that their produce can be asymmetric or do not have equal intensities.If radiating guide 2364 too away from, then damage by discontinuous.According to an embodiment of the present, the space between the dielectric filler 2368 in aerial array 2355 can be made up of the thickness of the thickness of wave guide wall 2366 of radiating guide 2364 and one or more isolated component between microwave antenna.According to an embodiment of the present, the space between the dielectric filler 2368 in aerial array 2355 can be between approximate 0.012 inch to 0.080 inch and preferably approximate 0.030 inch.According to an embodiment of the present, aerial array 2355 can have the wave guide wall 2366 of the approximate 0.003 inch of thickness of coating of band, and isolated component 2391 can have the thickness of approximate 0.024 inch.According to an embodiment of the present, wherein frequency-of-interest is approximate is 5.8 GHz, isolated component 2391 can to have between approximate 25 to approximate 40 and preferably approximate 27 dielectric constant.According to an embodiment of the present, wherein frequency-of-interest is approximate is 5.8 GHz, isolated component 2391 can to have between approximate 0.02 to approximate 0.07 and preferably approximate 0.04 loss angle tangent (tan δ).According to an embodiment of the present, wherein frequency-of-interest is approximate is 5.8 GHz, and isolated component 2391 can have at the extremely approximate 7+j5.6 of approximate 1.5+j3.4 and preferably be similar to the complex permeability of 2.7+j3.4.
Figure 45 is the side view of the alternate embodiments of waveguide assemblies according to an embodiment of the present.Figure 46 is the sectional view of the waveguide assemblies shown in Figure 45.According to an embodiment of the present, microwave choke 2386 also can be used as isolated component 2391.According to an embodiment of the present, metal rim on short metallic gasket between radiating guide 2364 (being set in apart from fixed range place, waveguide hole back) and outside microwave antenna 2364 can be used in form microwave choke 2386.According to an embodiment of the present, microwave choke 2386 can be used in waveguide assemblies 2358 so that the isolation realized between waveguide assemblies 2358 inner waveguide antenna 2364 and SAR concordance.According to an embodiment of the present, in space between radiating guide 2364, separate radiating guide 2364 by using the metallic gasket with specific thicknesses be set in apart from the hole specified distance of radiating guide 2364 thus produce microwave choke 2386.According to an embodiment of the present, the outside of radiating guide 2364 outside, uses by being set in the flange formed apart from hole same distance place and the metallic gasket with same size and the metallic plate extending to waveguide surface from pad to realize microwave choke 2386.According to an embodiment of the present, microwave choke 2386 is the fringing field generation propagation path of the long edge position existence of the radiating surface of the hole of radiating guide 2364.According to an embodiment of the present, microwave choke structure allows this margin signal to be coupled in a symmetrical in microwave choke 2386 for microwave antenna in waveguide assemblies 2358 and outer microwave antenna 2364.Therefore, microwave choke 2386 can strengthen the isolation in waveguide assemblies 2358 by the interaction reduced between adjacent waveguide antenna 2364, and strengthens the SAR pattern concordance between radiating guide 2364 by the loading condition introducing symmetry at the hole place of radiating guide 2364.
Figure 47 is the schematic diagram of system 2309 according to an embodiment of the present.According to an embodiment of the present, system 2309 can comprise isolating transformer 2316, coolant source 2310, generator 2301 and applicator 2320.According to an embodiment of the present, isolating transformer 2316 can be connected to AC power supplies 2318.According to an embodiment of the present, isolating transformer 2316 can provide power to generator 2301 and coolant source 2310.According to an embodiment of the present, generator 2301 can comprise DC power supply 2303, controller 2302, microwave links 2403(can be such as a series of microwave components) and vacuum source 2308.According to an embodiment of the present, controller 2302 can manage all system level inputs and control, such as: from power and the timing setting of front panel 2305; From the input of starting button 2464; From the input of stop button 2466; From the hardware error (reverse power error, amplifier failures) of microwave circuit; From temperature and the alignment error of applicator; And record reverse power, forward power and tissue temperature and coolant temperature in discrete instants transmission measurement data to interface 2420.According to an embodiment of the present, controller 2302 also can control antenna switch 2357, vacuum pump 2450 and vacuum spiral spool 2315.According to an embodiment of the present, vacuum source 2308 can comprise vacuum pump/driver 2307 and vacuum spiral spool 2315.According to an embodiment of the present, DC power supply 2303 can provide power to microwave links 2403 and controller 2302.According to an embodiment of the present, controller 2302 can guarantee that microwave links 2403 is by standardized operation.According to an embodiment of the present, microwave links 2403 can be connected to controller 2302.According to an embodiment of the present, controller 2302 can be connected to vacuum pump/driver 2307 by vacuum power signal 2323, and is in directly solenoid control signal 2321 and is connected to vacuum spiral spool 2315.According to an embodiment of the present, DC power supply 2303 can be the PM650-12C type Switching Power Supply of medical 650 watt of+12 volt that such as can obtain from Tumbler Technologies.According to an embodiment of the present, vacuum pump 2450 can be the 15988 model rotating vane pumps that such as can obtain from Clark Flow Solutions.According to an embodiment of the present, vacuum spiral spool 2315 can be the threeway the being discharged into atmospheric environment normally closed LW53KK8DGBG12/DC type electromagnetic valve that such as can obtain from Peter Paul Electronics Co.According to an embodiment of the present, applicator 2320 can be connected to generator 2301 by applicator cable 2334.According to an embodiment of the present, applicator cable 2334 can comprise coolant conduit 2324, energy cable 2322, coolant thermocouple electric wire 2331, coldplate thermocouple electric wire 2330 and duplexer signal 2481.According to an embodiment of the present, coolant conduit 2324 can be connected to coolant source 2310.According to an embodiment of the present, coolant conduit 2324 can comprise coolant supply pipe 2312 and coolant recurrent canal 2313.According to an embodiment of the present, coolant can be fed to applicator 2320 by coolant supply pipe 2312.According to an embodiment of the present, coolant turns back to coolant source 2310 by coolant recurrent canal 2313.According to an embodiment of the present, energy cable 2322 can be connected to generator 2301 by microwave out connector 2443.According to an embodiment of the present, the duplexer 2357 in applicator 2320 can be connected to the microwave links 2403 in generator 2301 by energy cable 2322 by microwave out connector 2443.According to an embodiment of the present, coolant thermocouple electric wire 2331 and antenna thermocouple electric wire 2330 can be connected to generator 2301 by temperature adapter 2482.According to an embodiment of the present, the cooling path thermocouple 2326 in applicator 2320 can be connected to the controller 2302 in generator 2301 by coolant thermocouple electric wire 2331 by temperature adapter 2482.According to an embodiment of the present, the coldplate thermocouple 2395 in applicator 2320 can be connected to the controller 2302 in generator 2301 by coldplate thermocouple electric wire 2330 by temperature adapter 2482.According to an embodiment of the present, duplexer signal 2481 can be connected to generator 2301 by duplexer adapter 2480.According to an embodiment of the present, the duplexer 2357 in applicator 2320 can be connected to the controller 2302 in generator 2301 by duplexer signal 2481 by duplexer adapter 2480.According to an embodiment of the present, disposable device 2363 can be connected to generator 2301 by vacuum tube 2319, and wherein this vacuum tube 2319 can comprise generator biological barrier 2317.According to an embodiment of the present, in system 2309, vacuum tube 2319 can be connected to generator 2301 by vacuum ports adapter 2484.According to an embodiment of the present, disposable device 2363 can be connected to vacuum spiral spool 2315 by vacuum ports adapter 2484 by vacuum tube 2319.According to an embodiment of the present, coolant source 2310 is by not shown for cooling fluid 2361() be fed to applicator 2320.According to an embodiment of the present, coolant source 2310 can be the NanoTherm cooler that can obtain from ThemoTek, Inc.According to an embodiment of the present, the cooling fluid 2361 from coolant source 2310 has the temperature range between approximate 5 to 40 degrees Celsius and is preferably similar to the temperature of 15 degrees Celsius.According to an embodiment of the present, coolant source 2310 can have flow rate that is between approximate 200 to 1000 ml/min and preferably approximate 500 mm/min.According to an embodiment of the present, coolant source 2310 can be designed to refrigeration cooling fluid 2361 and cooled cooling fluid 2361 be pumped across applicator 2320 and coolant cavity 2360 with the solid-state cooler protecting the skin be bonded in tissue cavity 2338 to avoid heat injury.According to an embodiment of the present, coolant source 2310 can be that be designed to freeze cooling fluid 2361 ground floor cooled cooling fluid 2361 being pumped across the skin that applicator 2320 and coolant cavity 2360 are bonded in tissue cavity 2338 with protection avoids the solid-state cooler of heat injury.
Figure 48 is the schematic diagram of microwave links 2403 according to an embodiment of the present.According to an embodiment of the present, agitator 2304 can be connected to isolator 2401a, it can be such as single pole single throw SPST reflexive pin type diode switch that this isolator 2401a can be connected to switch 2402(), it can be such as fixed attenuator that this switch 2402 can be connected to attenuator 2408a(), this attenuator 2408a can be connected to band filter 2404, this band filter 2404 can be connected to amplifier 2306, this amplifier 2306 can be connected to isolator 2401b, this isolator 2401b can be connected to directional coupler 2406.According to an embodiment of the present, agitator 2304 can have the output frequency of approximate 5.8 GHz.According to an embodiment of the present, agitator 2304 provides 5.8 stable GHz low-power level signals.According to an embodiment of the present, isolator 2401a can be used to protection agitator 2304 from the reflected power signal from amplifier 2306.According to an embodiment of the present, filter circuit comprises band filter 2404, and this band filter 2404 has the mid frequency at frequency-of-interest place.According to an embodiment of the present, filter circuit comprises band filter 2404, and this band filter 2404 has the mid frequency at approximate 5.8 GHz places.According to an embodiment of the present, the band filter 2404 that filter circuit comprises can be the waveguide cavity wave filter of the frequency band input eliminating ingoing power amplifier.According to an embodiment of the present, the band filter 2404 that filter circuit comprises can have the three dB bandwidth of approximate 25MHz.According to an embodiment of the present, amplifier 2306 can be suitable for the amplifier at frequency-of-interest place amplifying signal.According to an embodiment of the present, amplifier 2306 can be suitable for the amplifier at 5.8 GHz place amplifying signals.According to an embodiment of the present, amplifier 2306 can be the S51500-05 amplifier that can obtain from Locus Microwave.According to an embodiment of the present, amplifier 2306 can comprise internal bias circuit, match circuit and be suitable for maintaining stability and the control circuit providing suitably coupling and power stage under frequency-of-interest.According to an embodiment of the present, amplifier 2306 can be suitable for input signal to amplify 54dB.According to an embodiment of the present, isolator 2401b may be used for guard amplifier 2306 from reflected power signal.According to an embodiment of the present, energy cable 2322 can carry the microwave energy leaving microwave links 2403 from directional coupler 2406.According to an embodiment of the present, directional coupler 2406 can be connected to the attenuator 2408b that can be connected to power detector 2409b further.According to an embodiment of the present, the output of power detector 2409b can be forward power signal 2415.According to an embodiment of the present, directional coupler 2406 can be connected to the attenuator 2408c that can be connected to power detector 2409a further.According to an embodiment of the present, a pair power detector 2409b and 2409a can be used to measure forward and reverse power.According to an embodiment of the present, the output of attenuator 2409a can be reverse power signal 2417.According to an embodiment of the present, microwave links 2403 can be connected to microwave control signal 2413.According to an embodiment of the present, microwave control signal 2413 can comprise pwm control signal 2405, fault-signal 2407, purified signal 2411, forward power signal 2415 and reverse power signal 2417.According to an embodiment of the present, pwm control signal 2405 can be connected to switch 2402.According to an embodiment of the present, fault-signal 2407 can be produced by amplifier 2306.According to an embodiment of the present, purified signal 2411 can be connected to amplifier 2306.According to an embodiment of the present, power detector 2409 can be such as coaxial tunnel diode detector.
According to an embodiment of the present, by compare directional coupler 2406 place measure forward power signal 2415 and make power controller work from the request power of power control handle 2454.According to an embodiment of the present, power can be sampled from the output of amplifier 2306 by directional coupler 2406, and wherein directional coupler 2406 is connected to power detector 2409b.According to an embodiment of the present, directional coupler 2406 may be used for sending forward and reflection power for detector 2409a and 2409b(can be such as coaxial tunnel diode detector) power is provided.According to an embodiment of the present, the output of readout power detector 2409a and 2409b can be carried out by the change-over circuit in controller 2302 and fed back to the switch 2402 of the input of control amplifier 2306.According to an embodiment of the present, the duty factor of switch 2402 can control the output level from microwave links 2403, and the percent time that its breaker in middle 2402 is in connection is proportional with the percentage ratio of the peak power output produced from microwave links 2403.According to an embodiment of the present, when with 40% duty factor driving switch 2402, the microwave links with 100 watts of maximum outputs can provide 40 watts of outputs from microwave links 2403.According to an embodiment of the present, switch 2402 can work at the modulating frequency place when the output of pin type diode is linear.According to an embodiment of the present, switch 2402 can in the modulating frequency place work of approximate 7.2 kHz.
Figure 49 is the schematic diagram of controller 2302 according to an embodiment of the present.According to an embodiment of the present, modulate circuit 2410a can be connected to analog-digital converter 2412a, this analog-digital converter 2412a can be connected to forward power look-up table 2414, this forward power look-up table 2414 can be connected to multiplexer and UART(universal asynchronous receiver/transmitter) state machine 2418, it can be such as segregate RS232 interface that this state machine 2418 can be connected to interface 2420().According to an embodiment of the present, it can be such as digital comparator that forward power look-up table 2414 also can be connected to comparator 2424(), this comparator 2424 can be connected to pulse width modulation state machine 2422, and this state machine 2422 can be connected to logic 2438.According to an embodiment of the present, the duty factor circuit comprising logic 2438 can be used to provide pulse width modulation (PWM) control signal 2405 to control the output level by energy cable 2322.According to an embodiment of the present, modulate circuit 2410b can be connected to analog-digital converter 2412b, this analog-digital converter 2412b can be connected to reverse power look-up table 2416, and this reverse power look-up table 2416 can be connected to multiplexer and UART state machine 2418 and fault logic 2434.According to an embodiment of the present, reverse power look-up table 2416 and modulate circuit 2410b nurse one's health the voltage from power detector 2409a, to produce the pattern measurement of reverse power.According to an embodiment of the present, reverse power look-up table 2416 and modulate circuit 2410b are that circuit downstream outputs signal so that the reverse power of record measurement, or make safety decision-making.According to an embodiment of the present, modulate circuit 2410c can be connected to analog-digital converter 2412c, and this analog-digital converter 2412c can be connected to multiplexer and UART state machine 2418 and fault logic 2434.According to an embodiment of the present, modulate circuit 2410d can be connected to analog-digital converter 2412d, and this analog-digital converter 2412d can be connected to multiplexer and UART state machine 2418 and fault logic 2434.According to an embodiment of the present, multiplexer 2426 can be connected to antenna selection mode owner controller 2442, and this master controller 2442 can be connected to time status machine 2440, and this time status machine 2440 can be connected to logic 2438.According to an embodiment of the present, circuit antenna selection mode owner controller 2442 is provided to control the antenna conversion used in the applicator 2320 of multi-path antenna array 2355.According to an embodiment of the present, multiplexer 2426 can be connected to modulate circuit 2410d.According to an embodiment of the present, antenna selection mode owner controller 2442 can be connected to logic 2438.According to an embodiment of the present, analog-digital converter 2412e can be connected to comparator 2424 and multiplexer and UART state machine 2418 and fault logic 2434.
According to an embodiment of the present, microwave links 2403 is connected to switch 2402 by microwave control signal 2413.According to an embodiment of the present, forward power signal 2415 can be the input of modulate circuit 2410a.According to an embodiment of the present, reverse power signal 2417 can be the input of modulate circuit 2410a.According to an embodiment of the present, coolant temperature signal 2431 can be the input of modulate circuit 2410c.According to an embodiment of the present, antenna thermocouple cable 2433 can be the input of multiplexer 2426.According to an embodiment of the present, pedal signal 2437 can be the input of timer state machine 2440.According to an embodiment of the present, power control signal 2453 can be the input of analog-digital converter 2412e.According to an embodiment of the present, filtered coolant temperature signal 2461 can be the output of modulate circuit 2410c.According to an embodiment of the present, filtered antenna temperature signal 2459 can be the output of modulate circuit 2410d.According to an embodiment of the present, antenna selection signals 2463 can be the input and output of antenna selection mode owner controller 2442.According to an embodiment of the present, stop signal 2467 can be the input and output of timer state machine 2440.According to an embodiment of the present, initiating signal 2465 can be the input and output of timer state machine 2440.According to an embodiment of the present, rear cold (post-cool) timer-signals 2473 can be the input and output of timer state machine 2440.According to an embodiment of the present, energy timer-signals 2471 can be the input and output of timer state machine 2440.According to an embodiment of the present, pre-coo time signal 2469 can be the input and output of timer state machine 2440.According to an embodiment of the present, buzzerphone 2479 can be the output of logic 2438.According to an embodiment of the present, ready signal 2477 can be the output of logic 2438.According to an embodiment of the present, solenoid control signal 2321 can be the output of logic 2438.According to an embodiment of the present, duplexer signal 2481 can be the output of logic 2438.According to an embodiment of the present, pwm control signal 2405 can be the output of logic 2438.According to an embodiment of the present, purified signal 2411 can be the output of logic 2438.According to an embodiment of the present, duplexer signal 2490 can be the input of fault logic 2434.According to an embodiment of the present, fault-signal 2475 can be the output of fault logic 2434.According to an embodiment of the present, fault-signal 2475 can be the input of logic 2438 and timer state machine 2440.According to an embodiment of the present, serial signal 2445 can be connected to interface 2420.
According to an embodiment of the present, controller 2302 and microwave links 2403 can comprise pulse width modulation (PWM) servo control mechanism provides feedback so that the power stage of control amplifier 2306.According to an embodiment of the present, pulse width modulation servo control mechanism can gauge tap 2402(can be pin type diode switch), change-over circuit in attenuator 2408b and 2408c, power detector 2409a and 2409b and controller 2302.According to an embodiment of the present, the duty factor that can be inputted by the signal of control amplifier 2306 controls power stage.According to an embodiment of the present, the input power that can maintain amplifier 2306 during transmission cycle is to guarantee stability in amplifier 2306 and linear.
According to an embodiment of the present, controller 2302 produces pwm control signal 2405 to control to leave the power of microwave links 2403 to switch 2402.According to an embodiment of the present, can be such as input reference voltage by obtaining power control signal 2453(from the power control handle 2454 on front panel 2305) controller 2302 is worked.According to an embodiment of the present, when user by pressing starting button 2464 carry out initialization power time, power control signal 2453 by controller 2302 for generation of request forward power.According to an embodiment of the present, after a short period of time, duty factor circuit operates according to the feedback measured from forward power detector 2409b.According to an embodiment of the present, will actual measurement forward power signal 2415 be performed and ask comparing of forward power.According to an embodiment of the present, controller 2302 will make small adjustment to pwm control signal 2405 the forward power leaving microwave links 2403 to be remained in the specification of request forward power setting.According to an embodiment of the present, pwm control signal 2405 can between approximate 7.0 KHz and approximate 7.5 KHz and preferably approximate 7.2 KHz.According to an embodiment of the present, pwm control signal 2405 can be absolutely approximate.
According to an embodiment of the present, forward power look-up table 2414 and modulate circuit 2410a(can comprise filtering and amplifying circuit) conditioning from the voltage of power detector 2409b to produce the pattern measurement of forward power.According to an embodiment of the present, forward power look-up table 2414 and modulate circuit 2410a are that circuit downstream outputs signal to record measured forward power, or make control and safety decision-making.According to an embodiment of the present, forward power look-up table 2414 and modulate circuit 2410a produce the output voltage signal representing measured forward power.According to an embodiment of the present, forward power look-up table 2414 can be calibrated to compensate the characteristic of each power detector 2409b and amplifier 2306.According to an embodiment of the present, reverse power look-up table 2416 can specifically be calibrated to compensate the characteristic of single power detector 2409a and amplifier 2306.
Figure 50 is the schematic diagram of rear board 2311 according to an embodiment of the present.According to an embodiment of the present, rear board 2311 comprises foot-operated switch adapter 2436 and serial interface connector 2444.According to an embodiment of the present, foot-operated switch adapter 2436 can be connected to pedal signal 2437.According to an embodiment of the present, serial interface connector 2444 can be connected to serial signal 2445.
Figure 51 is the schematic diagram of front panel 2305 according to an embodiment of the present.According to an embodiment of the present, front panel 2305 can comprise power control handle 2454, vacuum control knob 2456, temperature adapter 2482, duplexer adapter 2480, vacuometer measuring device 2486, vacuum ports adapter 2484, antenna selection switch 2462, temperature indicator 2457, starting button 2464, stop button 2466, microwave out connector 2443, pre-cooling timer 2468, energy timer 2470, rear cold timer 2472, fault detector 2474, ready indicator 2476 and buzzer 2478.According to an embodiment of the present, temperature adapter 2482 can comprise coolant temperature adapter 2430 and one or more antenna temperature adapter 2429.According to an embodiment of the present, antenna temperature adapter 2429 can comprise antenna temperature adapter 2429a to antenna temperature adapter 2429d.According to an embodiment of the present, temperature indicator 2457 can comprise antenna temperature display 2458 and coolant temperature display 2460.
According to an embodiment of the present, user interface can be generator front panel 2305, it comprises user's input control part (such as power control handle 2454, vacuum control knob 2456, starting button 2464, stop button 2466, antenna selection switch 2462, pre-cooling timer 2468, energy timer 2470, rear cold timer 2472), user feedback features (such as vacuometer measuring device 2486, antenna selection switch 2462, temperature indicator 2457, pre-cooling timer 2468, energy timer 2470 and rear cold timer 2472) and adapter (such as temperature adapter 2482, vacuum ports adapter 2484, duplexer adapter 2480 and microwave out connector 2443).According to an embodiment of the present, during power transfer, measure tissue temperature for each selected radiating guide 2364, and this tissue temperature is presented on front panel 2305 by antenna temperature display 2458.According to an embodiment of the present, during power transfer, coolant temperature is continuously measured and the agent temperature indicator 2460 that is cooled is presented on front panel 2305.According to an embodiment of the present, can by engaging suitable antenna select button (being such as associated with the energy select button of antenna selection switch 2462), thus be select radiating guide 2364 from the microwave energy transfer of front panel 2305.According to an embodiment of the present, each selected radiating guide 2364 can be transferred energy to during the predetermined power timing period.
According to an embodiment of the present, the user interface of such as generator front panel 2305 can provide user feedback.According to an embodiment of the present, user feedback can comprise and uses such as antenna temperature display 2458 for each radiating guide display coldplate temperature (can indicate skin temperature) in waveguide array.According to an embodiment of the present, user feedback can comprise and uses such as coolant temperature display 2460 to show cooling fluid temperature in the applicator of the output in cooling fluid path.According to an embodiment of the present, user feedback can comprise and uses such as vacuometer measuring device 2486 to indicate the vacuum pressure of vacuum output.According to an embodiment of the present, user feedback can comprise ready indicator, such as ready indicator 2476, and to indicate, when system is ready for use.According to an embodiment of the present, user feedback can comprise fault detector, such as fault detector 2474, when breaks down to indicate.According to an embodiment of the present, antenna temperature display 2458 report before initializing treatment cycle is positioned at the temperature at coldplate thermocouple 2395 place below first institute's connection radiating guide 2364 started.According to an embodiment of the present, the temperature measured at coldplate thermocouple 2395 place can indicate the temperature of the skin surface below the tissue biological's barrier 2337 being positioned at contiguous coldplate thermocouple 2395.According to an embodiment of the present, the temperature measured at coldplate thermocouple 2395 place can with tissue biological's barrier 2337 of contiguous coldplate thermocouple 2395 below the temperature proportional of skin surface.According to an embodiment of the present, once treatment cycle, then antenna temperature display 2458 is with regard to the temperature of the tissue below report upon start up each radiating guide 2364, and once the completed treatment cycle, then antenna temperature display 2458 continues the tissue temperature below the last radiating guide 2364 started of display.
According to an embodiment of the present, power control signal 2453 can be the output of power control handle 2454.According to an embodiment of the present, vacuum control input signal 2455 can be the output of vacuum control knob 2456.According to an embodiment of the present, coolant thermocouple electric wire 2331 can be the input of coolant temperature adapter 2430.According to an embodiment of the present, coolant temperature signal 2431 can be the output of coolant temperature adapter 2430.According to an embodiment of the present, coldplate thermocouple electric wire 2330 can be the input of antenna temperature adapter 2429.According to an embodiment of the present, antenna thermocouple cable 2433 can be the output of antenna temperature adapter 2429.According to an embodiment of the present, duplexer signal 2481 can be the input of duplexer adapter 2480.According to an embodiment of the present, duplexer signal 2490 can be the output of duplexer adapter 2480.According to an embodiment of the present, antenna selection signals 2463 can be the input and output of antenna selection switch 2462.According to an embodiment of the present, filtered antenna temperature signal 2459 can be the input of antenna temperature display 2458.According to an embodiment of the present, filtered coolant temperature signal 2461 can be the input of coolant temperature display 2460.According to an embodiment of the present, initiating signal 2465 can be the input and output of starting button 2464.According to an embodiment of the present, stop signal 2467 can be the input and output of stop button 2466.According to an embodiment of the present, energy cable 2322 can be the input of microwave out connector 2443.According to an embodiment of the present, pre-coo time signal 2469 can be the input and output of pre-cooling timer 2468.According to an embodiment of the present, energy timer-signals 2471 can be the input of energy timer 2470.According to an embodiment of the present, rear cold timer-signals 2473 can be the input and output of rear cold timer 2472.According to an embodiment of the present, fault-signal 2475 can be the input of fault-signal 2474.According to an embodiment of the present, ready signal 2477 can be the input of ready indicator 2476.According to an embodiment of the present, buzzerphone 2479 can be the input of buzzer 2478.
Figure 52 is the schematic diagram of vacuum source 2308 according to an embodiment of the present.According to an embodiment of the present, vacuum source 2308 can comprise vacuum spiral spool 2315 and vacuum pump/driver 2307.According to an embodiment of the present, vacuum pump/driver 2307 can comprise variable voltage driver 2452 and vacuum pump 2450.According to an embodiment of the present, vacuum control input signal 2455 can be the input of variable voltage driver 2452, and solenoid control signal 2321 can be the input of vacuum spiral spool 2315.According to an embodiment of the present, solenoid control signal 2321 can be the input of vacuum spiral spool 2315.According to an embodiment of the present, vacuum pump/driver 2307 can be connected to vacuum spiral spool 2315 by pipe 2427.
Figure 53 is the schematic diagram of Controller Circuit Used in Microwave Power Amplifier 2419 according to an embodiment of the present.According to an embodiment of the present, Controller Circuit Used in Microwave Power Amplifier can be pulse width modulation (PWM) control circuit of the energy output being suitable for control 2322 place.According to an embodiment of the present, Controller Circuit Used in Microwave Power Amplifier 2419 can comprise agitator 2304, isolator 2401a, switch 2402, attenuator 2408a, band filter 2404, amplifier 2306, isolator 2401b and directional coupler 2406.According to an embodiment of the present, purified signal 2411 can be the input of amplifier 2306.According to an embodiment of the present, Controller Circuit Used in Microwave Power Amplifier 2419 can have output energy cable 2322, and this output energy cable 2322 can carry the microwave energy being delivered to applicator 2320.According to an embodiment of the present, Controller Circuit Used in Microwave Power Amplifier 2419 can comprise attenuator 2408b and 2408c, power detector 2409a and 2409b.According to an embodiment of the present, the output of power detector 2409a can be reverse power signal 2417.According to an embodiment of the present, the output of power detector 2409b can be forward power signal 2415.According to an embodiment of the present, reverse power signal 2417 can be the input of reverse power look-up table and modulate circuit 2423.According to an embodiment of the present, reverse power look-up table and modulate circuit 2423 can export reverse power error signal 2428.According to an embodiment of the present, reverse power look-up table and modulate circuit 2423 can export reverse power reading 2435.According to an embodiment of the present, forward power signal 2415 can be the input of forward power look-up table and modulate circuit 2421.According to an embodiment of the present, power transfer ON/OFF signal 2439 can be the input of forward power look-up table and modulate circuit 2421.According to an embodiment of the present, power control signal 2453 can be the input of forward power look-up table and modulate circuit 2421.According to an embodiment of the present, forward power look-up table and modulate circuit 2421 can have the input of reverse power look-up table and modulate circuit 2423.According to an embodiment of the present, forward power look-up table and modulate circuit 2421 can export forward output power error 2441.According to an embodiment of the present, forward power look-up table and modulate circuit 2421 can export forward output power error 2441.According to an embodiment of the present, forward power look-up table and modulate circuit 2421 can export forward power signal 2446.According to an embodiment of the present, forward power look-up table and modulate circuit 2421 can export forward power signal 2446 to duty factor circuit 2425.According to an embodiment of the present, power control signal 2453 and initiating signal 2465 can be the inputs of duty factor circuit 2425.According to an embodiment of the present, two modules, use forward power look-up table and modulate circuit 2421 and reverse power look-up table and modulate circuit 2423 to convert forward and reverse power reading to usable control signals and fault-signal.According to an embodiment of the present, look-up table is included in reverse power look-up table and modulate circuit 2423 to produce the output voltage signal representing tested reverse power.According to an embodiment of the present, each look-up table in reverse power look-up table and modulate circuit 2423 is calibrated to diode in circuit and amplifier.
Figure 54-58 is schematic diagrams of patient's positioning equipment 2492 according to an embodiment of the present.According to an embodiment of the present, patient's positioning equipment 2492 comprises arm support member 2493.According to an embodiment of the present, patient's positioning equipment 2492 comprises center support 2494.According to an embodiment of the present, patient's positioning equipment 2492 comprises substrate 2495.According to an embodiment of the present, patient's positioning equipment 2492 comprises head rest 2496.According to an embodiment of the present, patient's positioning equipment 2492 may be used for correctly position patient.According to an embodiment of the present, arm support member 2493 according to an embodiment of the present can and center support 2494 be formed in angle (A) between approximate 15 degree to approximate 35 degree.According to an embodiment of the present, arm support member 2493 according to an embodiment of the present can form the angle of approximate 25 degree with center support 2494.According to an embodiment of the present, patient's positioning equipment 2492 according to an embodiment of the present can have the size (B) of approximate 22 centimetres between arm support member 2493.According to an embodiment of the present, patient's positioning equipment 2492 can also comprise disposable cover (not shown), and it can be replaced for each patient.
Figure 59 is the schematic diagram for the treatment of model 2483 according to an embodiment of the present.According to an embodiment of the present, treating model 2483 can be flexible and transparent substrate.According to an embodiment of the present, suitable treatment model 2483 can comprise the multiple openings being arranged to predetermined pattern.According to an embodiment of the present, each opening or often organize opening and can be used to identify particular treatment element.According to an embodiment of the present, opening or opening group (such as device position point 2487) can be used to the area indicating the area for treatment will placing applicator 2320.According to an embodiment of the present, opening or opening group (such as applicator places mark 2489) can be used to indicate the skin will placing applicator alignment feature 2352.According to an embodiment of the present, can be used to indicate will the skin of injecting narcotic for opening or opening group (such as anesthesia injection mark 2485).According to an embodiment of the present, under the center of antenna hole, injecting narcotic can increase the amount of the predictability of result and the fluid needed for each treatment of minimizing.According to an embodiment of the present, the mark on model also can be used to indicate how many antennas that can to use according to the applicator position on axillary fossa in array.According to an embodiment of the present, the hole (such as boundary mark alignment identification 2491) in model also can be used to alignment treatment model 2493 and patient's boundary mark with it (such as tatoo, temporary tatt, skin tag, skin folding line, hair pattern, fashionable mark or birthmark).
Figure 60 is the simple sectional view of the medical treatment device 2300 engaging tissue according to an embodiment of the present.In the embodiment of the present invention shown in Figure 60, skin 1307 is bonded in tissue cavity 2338.In the embodiment of the present invention shown in Figure 60, corium 1305 and hypodermis 1303 are engaged with in tissue cavity 2338.In the embodiment of the present invention shown in Figure 60, skin surface 1306 is engaged with in tissue cavity 2338, make skin surface 1306 contact chamber wall 2354 at least partially, and thermo-contact coldplate 2340 at least partially.In the embodiment of the present invention shown in Figure 60, skin surface 1306 is engaged with in tissue cavity 2338, makes skin surface 1306 contact tissue interface 2336 at least partially.As shown in Figure 60, vacuum pressure can be used to promote corium 1305 and hypodermis 1303, thus is separated from muscle 1301 with hypodermis 1303 by corium 1305.As shown in Figure 60, vacuum pressure can be used to promote corium 1305 and hypodermis 1303, thus is separated from muscle 1301 with hypodermis 1303 by corium 1305, such as to protect muscle 1301 by limiting or eliminate the electromagnetic energy arriving muscle 1301.
Figure 61-64 shows tissue contours and the reduced graph of medical treatment device 2300 according to an embodiment of the invention.According to an embodiment of the present, waveguide assemblies 2358 can comprise radiating guide 2364.According to an embodiment of the present, the electromagnetic energy of such as microwave energy is radiated in corium 1305 by tissue 2362, and this tissue 2362 can be such as integral type or attached disposable device 2363.According to an embodiment of the present, medical treatment device 2300 can comprise coolant cavity 360 and coldplate 2340.In the embodiment of the present invention shown in Figure 61-64, can be that the peak value of such as peak value SAR, peak energy consume density or peak temperature can produce in the first tissue regions 1309.In the embodiment of the present invention shown in Figure 61-64, can be that the amplitude of the reduction of SAR, the power dissipation density of reduction or the temperature of reduction such as reduced produces in minor microstructure region 1311, and the amplitude reduced further be in the 3rd tissue regions 1313 and the 4th tissue regions 1315.As shown in Figure 61-64, corium 1305 is located away from hypodermis 1303 by interface 1308.As shown in Figure 61, Figure 63 and Figure 64, interface 1308 can be idealized as substantially straight line, so that simplified characterization, but as shown in Figure 64, in the tissue of reality, interface 1308 can be non-linear, discontinuous, coarse interface, and it also can comprise and striding across and many organizational structuries at disrupt tissue interface 1308 and organizational structure group.As shown in Figure 61-64, hypodermis 1303 is positioned on muscular tissue 1301.According to an embodiment of the present, electromagnetic radiation can be launched with the frequency such as between 5-6.5 GHz.According to an embodiment of the present, electromagnetic radiation can be launched with the frequency of such as approximate 5.8 GHz.According to an embodiment of the present, field extension device 2379(can be such as dispersing element 2378) coolant cavity 2360 can be positioned at.In an embodiment of the present invention, such as, in Figure 64 illustrated embodiment, field extension device 2379 may be used for such as extension and flattens the first tissue regions 1309.In the embodiment of the present invention shown in Figure 64, field extension device 2379 may be used for such as extension and flattens the damage formed in the first tissue regions 1309.According to an embodiment of the present, produce damage, such as, produce the damage shown in Figure 61-64 and can be used to treat patient skin.According to an embodiment of the present, produce damage, such as, produce the damage shown in Figure 61-64 and can be used to injury or destroy structure, such as, sweat gland in patient skin.
According to an embodiment of the present, disposable device 2363 comprises a large amount of beneficial aspects.According to an embodiment of the present, vacuum pressure can be evenly distributed to the either side of tissue biological's barrier 2337.According to an embodiment of the present, when realizing balanced, vacuum pressure can be uniformly distributed in tissue cavity 2338 and applicator chamber 2346.According to an embodiment of the present, use extensile tissue biological barrier 2337 and Vacuum Balance ensure that tissue biological's barrier 2337 will fit applicator 2320 far-end thus prevent from forming bubble between tissue biological's barrier 2337 and the far-end of applicator 2320.According to an embodiment of the present, use extensile tissue biological barrier 2337 and Vacuum Balance ensure that tissue biological's barrier 2337 fit coldplate 2340 distal side thus prevent from forming bubble between tissue biological's barrier 2337 and the distal side of coldplate 2340.According to an embodiment of the present, Vacuum Balance ensure that tissue biological's barrier 2337 is sealed in the far-end of applicator 2320 and is sealed in the surface of the skin be bonded in tissue cavity 2338, thus reduce or eliminates the air pocket that may cause undesirable disturbance in microwave field.According to an embodiment of the present, Vacuum Balance ensure that tissue biological's barrier 2337 is sealed in the distal side of coldplate 2340 and is sealed in the surface of the skin be bonded in tissue cavity 2338, thus reduce or eliminates the air pocket that may cause undesirable disturbance in microwave field.
According to an embodiment of the present, make tissue biological's barrier 2337 stretch and ensure that its flat far-end being butted on applicator 2320.According to an embodiment of the present, tissue biological's barrier 2337 stretches thus is formed substantially without interface of wrinkling with the far-end of applicator 2320.According to an embodiment of the present, make tissue biological's barrier 2337 stretch to make to produce interference engagement between the far-end of tissue biological's barrier 2337 and applicator 2320.According to an embodiment of the present, make in the remote extension of applicator 2320 to tissue cavity 2338, tissue biological's barrier 2337 stretched and ensure that the interference engagement between the far-end of tissue biological's barrier 2337 and applicator 2320.According to an embodiment of the present, applicator 2320 can be recessed to applicator intracavity up to approximate 0.020 inch.According to an embodiment of the present, the far-end of applicator 2320 can extend to 0-0.030 inch in tissue cavity 2338 and preferably approximate 0.010 inch, thus tissue biological's barrier 2337 is stretched and produce interference engagement between the far-end and tissue biological's barrier 2337 of applicator 2320.According to an embodiment of the present, the combination of the vacuum in interference engagement and applicator chamber 2346 makes air pocket, folding line and the fold that may otherwise produce in extensible tissue biological barrier 2337 minimize.
According to an embodiment of the present, biofluid can be isolated from generator 2301 by generator biological barrier 2317.According to an embodiment of the present, biofluid can be isolated from applicator 2320 by applicator biological barrier 2332.According to an embodiment of the present, biofluid can be isolated from applicator 2320 by tissue biological's barrier 2337.According to an embodiment of the present, applicator biological barrier 2332 provides the isolation between tissue cavity 2338 and applicator 2320, thus allows air to pass through but stop biofluid or other fluids (such as KY Jelly) to arrive applicator 2320.According to an embodiment of the present, the circuitous path in vacuum barrier 2343 and vacuum loop 2341 contributes to biofluid or other fluid isolation in applicator biological barrier 2332.According to an embodiment of the present, the circuitous path in applicator biological barrier 2332, vacuum loop 2341, vacuum barrier 2343 and vacuum passage 2333 combination be placed in before vacuum barrier 2343 prevented back pressure (such as issuable back pressure when by making vacuum tube and atmospheric pressure ventilate to terminate evacuation) to order about biofluid or other fluids enter applicator chamber 2346.According to an embodiment of the present, applicator biological barrier 2332 can be can from Harrington Plastics obtain with approximate 0.1 micron of to 1.0 microns and preferably hydrophobic filter in aperture of approximate 0.45 micron.
According to an embodiment of the present, applicator 2320 comprises a large amount of beneficial aspects.According to an embodiment of the present, aerial array 2355 contributes to producing large damage or damage field under applicator 2320 single is placed.According to an embodiment of the present, aerial array 2355 contributes to producing the damage up to being similar to 30 millimeters × approximate eight millimeters of cross sections.According to an embodiment of the present, can contribute to producing continuous damage by rapid translating microwave energy between the radiating guide 2364 in aerial array 2355.According to an embodiment of the present, can contribute to producing discontinuous damage by the selected radiating guide 2364 microwave energy is applied in aerial array 2355.According to an embodiment of the present, can contribute to producing damage under the part on tissue boundary surface 2336 by the selected radiating guide 2364 microwave energy is applied in aerial array 2355.According to an embodiment of the present, the position that aerial array 2355 can be used to optionally need user produces damage.
According to an embodiment of the present, generator 2301 comprises a large amount of beneficial aspects.According to an embodiment of the present, when fault condition being detected, such as when following condition, generator 2301 will not start or by therapy discontinued: energy cable 2322 is not connected, and one or more coldplate thermocouple 2395 or cooling path thermocouple 2326 are not connected; One or more coldplate thermocouple 2395 place measure temperature beyond predetermined restriction, such as 45 degrees Celsius; The temperature (can indicate the temperature of coolant cavity 2360) measured at cooling path thermocouple 2326 place exceeds predetermined restriction, such as 45 degrees Celsius; There is fault in amplifier 2306; Reflection power exceeds predetermined restriction, such as 19.5 watts.According to an embodiment of the present, when detect there is fault condition in PWM servo circuit time, such as, when following condition, generator 2301 will start or therapy discontinued: the power stage of microwave links 2403 is not maintained in predetermined window; In 400 ms of instruction, do not set the power stage of microwave links 2403; The power stage of microwave links 2403 is not maintained in preset range, such as ask power ± 13 watts in; The reflection power measured at directional coupler 2406 place and the ratio of forward power exceed predetermined restriction.According to an embodiment of the present, when such as following fault condition being detected, generator 2301 will start or therapy discontinued: the temperature measured at one or more coldplate thermocouple 2395 or cooling path thermocouple 2325 place increases or the speed that reduces exceeds predetermined restriction; The speed of the temperature measured at one or more coldplate thermocouple 2395 or cooling path thermocouple 2325 place increases or reduces to exceed predetermined restriction.According to an embodiment of the present, generator 2301 can transmit the output within the scope of 40-100 watt.According to an embodiment of the present, generator 2301 can increase with the increment of 5 watts or reduce output.According to an embodiment of the present, generator 2301 can to keep in output power range ± the precision of 3 watts.According to an embodiment of the present, generator 2301 can keep the output frequency of 5.8 GHz ± approximate 25 KHz.According to an embodiment of the present, the temperature of cooling fluid 2361 can to control in the scope of approximate-5 to approximate 600 and the precision of approximate ± 2.50 degrees centigrade by cooler 2310.
According to an embodiment of the present, the present invention includes patient's position fixing process.According to a kind of embodiment of process of the present invention, can use such as patient's positioning equipment 2492 that patient is positioned at supine position.According to a kind of embodiment of process of the present invention, position patient can be carried out by the arm of position patient to expose axillary fossa (such as by lifting the arm of patient and the hands of patient being placed on its lower head).According to a kind of embodiment of process of the present invention, user can identify or produce the boundary mark on patient's axillary fossa.According to a kind of embodiment of process of the present invention, such boundary mark can be such as birthmark, speckle, cicatrix or other personal features.According to a kind of embodiment of process of the present invention, can by using such as pen, permanent marking device, to tatoo or the prepared Chinese ink labelling of little sterilization produces such boundary mark.
According to an embodiment of the present, the present invention includes treatment road sign.According to a kind of embodiment of process of the present invention, once patient is located and identifies or create suitable boundary mark, then boundary mark can be used to produce treatment road sign.According to an embodiment of the present, the model of such as treating model 2483 can be used to produce treatment road sign.According to a kind of embodiment of process of the present invention, treatment model 2483 can be used to the position of the various road sign elements identifying therapeutic scheme.According to a kind of embodiment of process of the present invention, treatment model 2483 can be used to the road sign element in labelling area for treatment, and area for treatment is such as the axillary fossa of the various elements with area for treatment.According to a kind of embodiment of process of the present invention, such element can comprise such as one or more fix position 2485 and one or more device position point 2487.According to a kind of embodiment of process of the present invention, such element can comprise such as one or more fix position 2485 and one or more applicator and place labelling 2489.According to a kind of embodiment of process of the present invention, it can be alignment mark of such as tatooing that such element can comprise such as one or more fix position 2485 and one or more boundary mark alignment mark 2491().According to a kind of embodiment of process of the present invention, can on patient skin labelling outlet mark element position before use in area for treatment the boundary mark identifying or produce to carry out locating therapy model 2483.According to a kind of embodiment of process of the present invention, identify that the labelling of road sign element can by doctor for guiding therapeutic scheme.
According to a kind of embodiment of process of the present invention, in some cases, once-existing section of possibility between treatment, such as a few week, to be enough to need to provide additional anesthetic before continual cure area for treatment.According to a kind of embodiment of process of the present invention, when time-event or time period be enough to remove or disappear be coated with previously produced for identifying the labelling of road sign element time, may be necessary that by such as make to treat model 2483 and be aligned in the boundary mark that previously identifies or produce and use treatment model 2483 again labelling skin again set up these labellings.According to a kind of embodiment of process of the present invention, the photo of area for treatment can be used to help to produce or align treatment model 2483 so that treatment subsequently.
According to a kind of embodiment of process of the present invention, once treat full area for treatment, then the dresser in the region modified can be needed to treat the region needing modification by such as using only treatment.
According to an embodiment of the present, the present invention includes anaesthesia process.According to a kind of embodiment of process of the present invention, therapeutic scheme can comprise anesthesia procedures region at least partially.According to a kind of embodiment of process of the present invention, when therapeutic scheme comprises the region of anaesthetizing and will be treated, the fix position 2485 on treatment model 2483 can be used to identify and mark in area for treatment and will be injected narcotic position.According to a kind of embodiment of process of the present invention, suitable anesthetis can comprise lignocaine or be with adrenergic lignocaine.According to a kind of embodiment of process of the present invention, anesthetis can be injected in hypodermic layer.According to a kind of embodiment of process of the present invention, suitable lidocaine concentrations can comprise the lidocaine solution of 2%, 3%, 4% or 5%.According to a kind of embodiment of process of the present invention, suitable Adrenaline Concentration can comprise the solution of 1 to 100000.According to a kind of embodiment of process of the present invention, suitable injection system can comprise ring block or penetration mode.According to a kind of embodiment of process of the present invention, in one is treated, with 1:100, the anesthetis be made up of 2% lignocaine of 000 Adrenaline Concentration can with every square centimeter of approximate every three square centimeter of 1.2 cc of 0.4 cc(of skin surface in area for treatment) Cmax be injected in area for treatment.According to a kind of embodiment of process of the present invention, for having the applicator of the aerial array 2355 comprising four radiating guides 2364, narcotic appropriate amount can be the approximate 0.3 every injection site of cc.According to a kind of embodiment of process of the present invention, fix position can be positioned under the center of the hole of radiating guide 2364.According to a kind of embodiment of process of the present invention, each axillary fossa can use the anesthetis of approximate 10 cc.According to a kind of embodiment of process of the present invention, each axillary fossa can use the anesthetis of approximate 20 cc.According to a kind of embodiment of process of the present invention, narcotic Cmin can be approximate 0.2 cc every square centimeter or the approximate 0.15 every injection site of cc.According to a kind of embodiment of process of the present invention, in order to minimize the Fluid Volume of injection and thus minimize the change organizing dielectric property caused by anesthetis, may be necessary that and utilize specific anesthetis concentration, such as with 1 to 100, the Adrenaline Concentration of 000 4% lignocaine, the total amount of the anesthetis fluid of use can be reduced such as half by it.According to a kind of embodiment of process of the present invention, use additional anesthetic agent that energy can be made more uniformly to be distributed in destination organization, and the selectivity of energy can be reduced by the energy density reduced in given tissue regions.
According to an embodiment of the present, the present invention includes the process of correct location applicator 2320.According to a kind of embodiment of process of the present invention, therapeutic scheme can also comprise locating therapy equipment, such as disposable for applicator 2320 device 2363 is positioned on the district that will be treated in area for treatment, such as vacuum acquisition methods is used to obtain tissue in such as tissue cavity 2338, by the microwave energy be such as exposed to from applicator 2320 treat obtain tissue, and by such as from tissue cavity 2338 remove vacuum pressure to discharge obtain tissue.According to a kind of embodiment of process of the present invention, therapeutic equipment can be moved to the new treatment region in area for treatment subsequently, and repeatedly process until the treated district that will be treated or its limit subset.According to an embodiment of the present, when therapeutic equipment moves to another location from a position, road sign treatment labelling can be used to therapeutic equipment to be aligned on non-treated tissue.According to an embodiment of the present, road sign treatment labelling also can be used to guarantee the tissue with in predefined procedure treatment area for treatment.
According to an embodiment of the present, the present invention includes the process for generation of the damage in patient skin.According to a kind of embodiment of process of the present invention, for obtaining the tissue effect of needs when applying energy, correct location applicator 2320 may be important.According to a kind of embodiment of process of the present invention, when applicator 2320 and disposable device 2363 are placed in against skin surface, tissue can be obtained by being drawn in by tissue in tissue cavity 2338.According to a kind of embodiment of process of the present invention, tissue acquisition can be realized by such as producing vacuum in tissue cavity 2338.According to a kind of embodiment of process of the present invention, once be organized in tissue cavity 2338, then microwave energy can from the distal end radiation of therapeutic equipment in tissue.According to a kind of embodiment of process of the present invention, the microwave energy of radiation can pass epidermis and corium at least partially, and this microwave energy can reflect the critical interfaces left in skin at least partially, such as corium-subcutaneous interface or the interface between corium and gland shape region.According to a kind of embodiment of process of the present invention, when microwave energy to be radiated in obtained tissue and to be reflected off critical interfaces, can produce standing wave, this can cause producing peak value SAR region in the intradermal of contiguous critical interfaces.According to a kind of embodiment of process of the present invention, tissue in peak value SAR region will be not dielectrically heated, thus the tissue destroying or damage in peak value SAR region and produce can such as by conduct or radiation be transmitted to the heat of surrounding tissue (comprising the tissue be positioned at below critical interfaces).According to a kind of embodiment of process of the present invention, its heat propagated can destroy or damage structure, comprises the sweat gland or hair follicle that are such as positioned at and propagate heat path.According to a kind of embodiment of process of the present invention, by microwave energy propagate into by cause in injury tissue direct dielectric heating can increase propagate heat the injury that produces.According to a kind of embodiment of process of the present invention, can by such as control obtain the surface of tissue temperature reduce or eliminate the tissue injury owing to such as propagating in epidermis and dermis that heat causes.According to a kind of embodiment of process of the present invention, can by such as make cooling fluid 2361 flow through obtain the applicator 2320 of the near surface of tissue far-end control obtain the temperature of tissue.According to a kind of embodiment of process of the present invention, can by such as applying to cool skin surface before microwave energy, when applying microwave energy cooling skin surface or after applying microwave energy, cool skin surface control obtain the temperature of the surface of tissue.
According to a kind of embodiment of process of the present invention, during the tissue effect that generation is desirable in many skin types (comprising people, pig and mammiferous skin), this process is effective.According to a kind of embodiment of process of the present invention, when treating mammal in addition to a person maybe when treating various disease, disease or area for treatment, described process can be changed by using the treatment model of remodeling to produce treatment road sign.
According to an embodiment of the present, the present invention includes the process used according to system of the present invention.According to a kind of embodiment of process of the present invention, in the treatment using native system, various power, time and chilling temperature setting and algorithm and its dependent variable, such as biological barrier structure, can be used to produce acceptable clinical effectiveness.According to a kind of embodiment of process of the present invention, unacceptable clinical effectiveness can comprise serious skin damage.According to a kind of embodiment of process of the present invention, clinical relevant long-term injury should do not caused for the epidermis or upper corium for the treatment of patient (such as human or animal).According to a kind of embodiment of process of the present invention, serious skin damage can comprise serious burn and the foaming of skin.According to a kind of embodiment of process of the present invention, unacceptable clinical effectiveness can comprise the loss (namely can cause ulcer or the open sore part of infection) of physical integrity or the visible cicatrix of epidermal area.According to a kind of embodiment of process of the present invention, the aesthetics that unacceptable clinical effectiveness can comprise skin changes, it can comprise: the undesirable outward appearance of therapentic part or texture change, this is the direct result of application of microwave energy, comprises the undesirable permanent aesthetic variation of therapentic part color and the undesirable obvious permanent aesthetic variation of skin texture.According to a kind of embodiment of process of the present invention, aesthetic variation that is that occur during treatment or that need the time to solve afterwards may not be that undesirable aesthetics changes.According to a kind of embodiment of process of the present invention, be wish when using native system treatment to the injury of fat, but can not reach the degree that is harmful to for the treatment of patient.According to a kind of embodiment of process of the present invention, unacceptable clinical effectiveness can comprise the injury of blood vessel to large and muscle.
According to a kind of embodiment of process of the present invention, use native system treatment after, when with control tissue samples compared with time, it is abnormal that the apocrine gland (when it is present) under the corium/corium of therapentic part in border region should show.According to a kind of embodiment of process of the present invention, use native system treatment after, when with control tissue samples compared with time, it is abnormal that the exocrine gland (when it is present) under the corium/corium of therapentic part in border region should show.According to a kind of embodiment of process of the present invention, after the treatment of use native system, gland structure should structurally be changed.According to a kind of embodiment of process of the present invention, after the treatment of use native system, the injury for hair follicle may be desired result, because this contributes to permanently removing hair.
According to a kind of embodiment of process of the present invention, start treatment by applicator 2320 being placed in above the tissue that will be treated.According to a kind of embodiment of process of the present invention, started by click starting button 2464 and bleed with continual cure.According to a kind of embodiment of process of the present invention, carry out continual cure by the tissue obtained in chamber 2338.According to a kind of embodiment of process of the present invention, by making cooling fluid 2361 through applicator 2320 thus cooling the tissue be bonded in tissue cavity 2338, carry out continual cure.According to a kind of embodiment of process of the present invention, by carrying out continual cure with scheduled time through-put power.According to a kind of embodiment of process of the present invention, by comprising radiating guide 2364a, 2364b, 2364c and 2364d in one embodiment through radiating guide 2364() circulation microwave energy carrys out continual cure.According to a kind of embodiment of process of the present invention, carry out continual cure by continuing the cooling tissue be bonded in tissue cavity after stopping power delivery after one is predetermined in the cold period.According to a kind of embodiment of process of the present invention, carry out continual cure by the vacuum pressure discharged in tissue cavity 2338 after process cold after end.According to a kind of embodiment of process of the present invention, remove applicator 2320 by treatment site and disposable device 2363 carrys out continual cure.According to a kind of embodiment of process of the present invention, when there is additional treatment position and needing therapeutic process, by mobile applicator 2320 to next position and repeat step in previous steps or more step come continual cure.According to a kind of embodiment of process of the present invention, continual cure is until treated all plan positions.
According to an embodiment of the present, the present invention includes program elements.According to a kind of embodiment of process of the present invention, the anesthetis that the key element of process can comprise use, the energy used, the cooling of using and the vacuum pressure used.According to a kind of embodiment of process of the present invention, comprise the anesthetis such as used, the energy used, the cooling of using and the program elements of vacuum pressure used can be modified based on patient characteristic (such as skin thickness).
According to an embodiment of the present, the present invention includes the process for applying energy to the area for treatment in patient.According to a kind of embodiment of process of the present invention, the energy putting on tissue can be determined according to the time quantum being radiated in-house power and power unlatching.According to a kind of embodiment of process of the present invention, being radiated in-house ceiling capacity can be the amount producing required damage and do not injure the necessary energy of its hetero-organization.According to a kind of embodiment of process of the present invention, being radiated in-house least energy can be the amount producing the necessary energy of required damage.According to a kind of embodiment of process of the present invention, tissue effect's (comprising unwanted tissue effect) can become with the energy of per unit area.According to a kind of embodiment of process of the present invention, the energy spread apart is more, then tissue effect is less.According to a kind of embodiment of process of the present invention, the ceiling capacity being transferred to skin can be the energy causing not extending to intraepidermal damage.According to a kind of embodiment of process of the present invention, the ceiling capacity being transferred to skin can be the energy causing the damage extended in corium the first half.According to a kind of embodiment of process of the present invention, the ceiling capacity being transferred to skin can be the energy of the damage causing extending on corium in 2/3rds parts.According to a kind of embodiment of process of the present invention, being radiated in-house power can become with the power at output generator place and applicator loss (comprising the loss in applicator cable).According to a kind of embodiment of process of the present invention, applicator loss can be such as be similar to 50 percent, (desirable or in loss-free applicator, be radiated in-house power and substantially equal the power that generator exports) only approximate 50/1sts of the power that generator 2301 is launched actually to be coupled in skin.According to an embodiment of the present, in applicator 2320 according to the present invention, loss is determined according to many factors, and described factor is such as cooling fluid 2361 composition, coolant cavity 2360 thickness, coldplate 2340 composition and coldplate 2340 thickness.According in the system 2309 of an embodiment of the present invention, wherein the loss of applicator 2320 is approximate 50 percent, the period then will the microwave power of generator radiation 80 watts being needed to continue 2.5 to 3.5 seconds, thus the intradermal of the tissue kept in approximate 100 joules to applicator far-end of coupling.According to an embodiment of the present, in the embodiment of the present invention that hope is treated with following condition, namely when microwave energy with the frequency radiation of approximate 5.8 gigahertzs by applicator 2320 and cooling fluid 2361 is cooled to approximate 15 degree celsius temperature and cycles through coolant cavity 2360 time, expection is produced desirable damage in the axillary fossa of human patients.According to a kind of embodiment of process of the present invention, expect such treatment to injure or damage at least sweat gland (such as apocrine gland or exocrine gland) of human patients and significantly can not injure the skin for the treatment of region outside.According to an embodiment of the present, in use, there is the applicator 2320 of four aerial arrays 2355 and have in the process of rear cold period of approximate 20 seconds, can at approximate 35 seconds internal therapy 1 × 3 cm area.
According to an embodiment of the present, have in the system 2309 of 2dB loss in applicator cable (energy cable 2322, duplexer 2357 and interconnect cable 2372 that can be long by such as 6 feet be formed), it is desirable to reduce approximate 37% from the signal of generator 2301 before arriving radiating guide 2364.According to an embodiment of the present, in following system 2309, namely because the absorption of such as cooling fluid 2361 and spurious emissions cause is 2dB from the loss being input to the tissue that tissue cavity 2338 engages of radiating guide 2364, the signal now from the input of radiating guide 2364 reduces to be similar to 37% between the input and skin surface of radiating guide 2364.According to an embodiment of the present, have 2dB cable loss and 2dB applicator in the system 2309 of the loss of tissue, signal power exports at generator 2301 and be reduced approximate 60% between tissue load.According to an embodiment of the present, in system 2309, the generator 2301 exporting 80 watts is coupled in tissue by causing the microwave power of approximate 32 watts, and the generator 2301 exporting 60 watts is coupled in tissue by causing the microwave power of approximate 24 watts, and the generator exporting 55 watts is coupled to causing the microwave power of approximate 22 watts in tissue.According in the system 2309 of an embodiment of the present invention, can pass through the element in change microwave circuit, such as cable laying, regulates the power arriving tissue.
According to an embodiment of the present, the present invention includes application vacuum to obtain the process of the tissue in tissue cavity 2338.According to an embodiment of the present, the vacuum putting on disposable device 2363 should be enough to make skin engagement in the tissue cavity 2338 of applicator, is butted on tissue boundary surface 2336 so that tissue is flat and can not injures tissue.According to an embodiment of the present, for the tissue cavity 2338 with approximate 1 cubic inch of (TS) volume and there are approximate 3.8 area in square inches tissue boundary surface 2336 for, suitable vacuum pressure can be between approximate 20 to two ten seven and preferably approximate 20 inches of mercury (measuring in the output of vacuum pump).According to an embodiment of the present, obtain tissue completely in order to ensure before energy applications to applicator, can obtain in the period in a vacuum before energy applications and apply vacuum.According to an embodiment of the present, it can be such as two to three seconds that suitable vacuum obtains the period.According to an embodiment of the present, successfully can obtain by not having vacuum sound to carry out signalisation at the far-end of applicator 2320.According to an embodiment of the present, can by indicating successful vacuum to obtain from the sound of generator 2301 or visual signal.According to an embodiment of the present, vacuum obtains and can be used to further on skin, produce suction sign, and this identifies contributing to user the region be treated.
According to an embodiment of the present, stop to after organizing transmission energy in applicator 2320, vacuum pressure can be maintained tissue to be remained on a scheduled time slot in tissue cavity 2338.According to an embodiment of the present, the described period can be cool the period after such as treating, and in this period, tissue is kept the cooling fluid against coldplate and continues to loop through applicator.According to an embodiment of the present, the suitable rear cold period can be between approximate zero to six ten seconds and preferably approximate 20 seconds.According to an embodiment of the present, the suitable rear cold period is specified by the amount of the energy being transferred to tissue.According to an embodiment of the present, when applicator is in the rear cold stage, generator also can produce sound or visual signal, so that applicator is not removed too early.
According to an embodiment of the present, narcotic process is transmitted before present invention resides in patient's upper use micro-wave therapeutic equipment.According to an embodiment of the present, transmission anesthetis can affect about being transferred to the decision organizing how many energy, because anesthetis can absorb some emittance, stops it to arrive area for treatment.According to an embodiment of the present, although such as injector to inject can be used to transmit anesthetis, but transmit narcotic alternative method and can comprise microneedle array or iontophoresis device.According to an embodiment of the present, anesthetis also can be injected in oil layer or be injected in the mode intercepting all neural perception in treatment region (axillary fossa of such as human patients).
According to an embodiment of the present, the present invention includes the method measuring skin thickness.According to an embodiment of the present, the skin thickness in area for treatment also can affect the amount that be transmitted the energy obtaining the tissue effect required.According to an embodiment of the present, thicker skin can need more energy correctly to treat.According to an embodiment of the present, a kind of mode of skin thickness in concrete region of measuring applies microwave energy by skin surface to monitor the temperature of skin surface.According to an embodiment of the present, particularly, the slope that temperature increases can indicate the skin thickness below applicator.According to an embodiment of the present, such as, before treated tissue, the short pulse of microwave energy can be used to indicate skin thickness by observed responses in the skin temperature of this pulse, and if skin temperature response is relatively slow, then the response of this skin temperature can be used for the amount of the treatment energy by such as increasing transmission and changes the amount of the energy of transmission.
According to an embodiment of the present, the present invention includes treatment model.Performing in process according to an embodiment of the present, user can use such as treats model 2483 to produce road sign.According to an embodiment of the present, such as, when treating axillary fossa, user can use the treatment model 2483 being designed to arm-pit areas.According to an embodiment of the present, such model can be selected to the axillary fossa of adaptive patient, the approx. dimension of axillary fossa, and can select from model class library, the hair district of the length and width or axillary fossa of such as passing through use axillary fossa is as choice criteria.According to an embodiment of the present, the suitable model for axillary fossa can be oval or pyriform.
According to an embodiment of the present, except using axillary fossa size and dimension to select suitably to treat except model 2483, the feature of axillary fossa or arbitrarily area for treatment can be used to select suitable applicator 2320 or for selecting suitable starting algorithm for the radiating guide 2364 in concrete applicator or aerial array.
According to an embodiment of the present, present invention resides on patient skin and make with lubricator to contribute to obtaining the method for tissue.According to an embodiment of the present, process can be included on skin and make with lubricator (such as K-Y jelly) with auxiliary acquisition.According to an embodiment of the present, process can comprise the friction using and lubricate and reduce when skin is drawn in tissue cavity 2338.According to an embodiment of the present, process can comprise the structural power using and lubricate and balance around tissue cavity 2338.According to an embodiment of the present, process can comprise and makes with lubricator auxiliaryly to guarantee so that the mode be correctly positioned in tissue cavity 2338 obtains destination organization by destination organization.According to an embodiment of the present, process can comprise the size and persistent period that make with lubricator to reduce suction sign.According to an embodiment of the present, process can comprise the size of the air pocket between surface and tissue boundary surface 2336 making the skin with lubricator reduced in tissue cavity 2338.
According to an embodiment of the present, the present invention includes a large amount for the treatment of characterized.According to an embodiment of the present, the method reducing perspiration is described.According to an embodiment of the present, the method reducing perspiration generation in patient body is described.According to an embodiment of the present, the method for the treatment of axillary fossa hyperhidrosis is described.According to an embodiment of the present, the method for the treatment of hyperhidrosis is described.According to an embodiment of the present, the method removing hair is described.According to an embodiment of the present, the method preventing hair from regrowing is described.According to an embodiment of the present, the method for the treatment of bromhidrosis is described.According to an embodiment of the present, method tissue being removed to nerve is described.According to an embodiment of the present, the method for the treatment of portwine stain is described.According to an embodiment of the present, the angiomatous method for the treatment of is described.According to an embodiment of the present, the psoriasic method for the treatment of is described.According to an embodiment of the present, the method reducing perspiration is described.According to an embodiment of the present, the method reducing perspiration is described.According to an embodiment of the present, electromagnetic energy is used to Acne treatment.According to an embodiment of the present, the method for the treatment of sebaceous gland is described.According to an embodiment of the present, the method for eliminating bacteria is described.According to an embodiment of the present, the method eliminating bacterium acidi propionici is described.According to an embodiment of the present, the method for the treatment of inflammation is described.
According to an embodiment of the present, electromagnetic energy can be used to reduce perspiration.According to an embodiment of the present, the perspiration that electromagnetic energy can be used in minimizing patient body produces.According to an embodiment of the present, electromagnetic energy can be used to the hyperhidrosis for the treatment of axillary fossa.According to an embodiment of the present, electromagnetic energy can be used to treat hyperhidrosis.According to an embodiment of the present, electromagnetic energy can be used to remove hair.According to an embodiment of the present, electromagnetic energy can be used to prevent hair regeneration.According to an embodiment of the present, electromagnetic energy can be used to treat bromhidrosis.According to an embodiment of the present, electromagnetic energy can be used to cutting tissue neural.According to an embodiment of the present, electromagnetic energy can be used to treat portwine stain.According to an embodiment of the present, electromagnetic energy can be used to treat hemangioma.According to an embodiment of the present, electromagnetic energy can be used to treat psoriasis.According to an embodiment of the present, electromagnetic energy can be used to reduce perspiration.In an embodiment of the present invention, electromagnetic energy can be used to Acne treatment.In an embodiment of the present invention, electromagnetic energy can be used to treat sebaceous gland.In an embodiment of the present invention, electromagnetic energy can be used to eliminating bacteria.In an embodiment of the present invention, electromagnetic energy can be used to eliminate bacterium acidi propionici.In an embodiment of the present invention, electromagnetic energy can be used to from hair follicle cleaning scaling fat.In an embodiment of the present invention, electromagnetic energy can be used to the hair follicle clearing up blocking.In an embodiment of the present invention, electromagnetic energy can be used to eliminate blackhead.In an embodiment of the present invention, electromagnetic energy can be used to clear up blackhead.In an embodiment of the present invention, electromagnetic energy can be used to clear up milium.In an embodiment of the present invention, electromagnetic energy can be used to reduce inflammation.In an embodiment of the present invention, electromagnetic energy can be used to burn fat.In an embodiment of the present invention, electromagnetic energy can be used to reduce liparitosis.
According to an embodiment of the present, the disposable medical equipment of description comprises: the tissue cavity being positioned at disposable member distal end; Be positioned at the applicator chamber of disposable member proximal; Separate tissue biological's barrier of tissue cavity and applicator interface (interface); And the vacuum loop in conjunctive tissue chamber and applicator chamber.According to an embodiment of the present, tissue cavity can comprise: tissue boundary surface, and tissue boundary surface comprises: around the vacuum passage of tissue biological's barrier; To flow the vacuum ports be communicated with vacuum passage and vacuum loop; And around the chamber wall of tissue cavity.According to an embodiment of the present, chamber wall also comprises compliant member.According to an embodiment of the present, compliant member has the height between approximate 0.15 inch to approximate 0.25 inch.According to an embodiment of the present, compliant member has the height of approximate 0.25 inch.According to an embodiment of the present, chamber wall also comprises the lubricant being at least partially coated with chamber wall.According to an embodiment of the present, lubricant is selected from by silicone oil, Teflon, Parylene or the group that forms of other suitable coating materials being convenient to obtain tissue.According to an embodiment of the present, applicator chamber comprises: applicator interface surface, and wherein applicator interface surface is around tissue biological's barrier; Around the applicator interface wall of applicator interface surface; And the vacuum seal of proximal end in applicator chamber, vacuum seal is oriented to seal applicator chamber hermetically when applicator is positioned at applicator intracavity.According to an embodiment of the present, the degree of depth that applicator chamber has is enough to receive and engages applicator so that the distal contact tissue biological barrier of applicator, to produce interference engagement between the far-end and tissue biological's barrier of applicator.According to an embodiment of the present, the degree of depth that applicator chamber has is enough to guarantee that in the applicator of applicator intracavity, biological barrier being moved in tissue cavity is similar between 0.001 inch to approximate 0.030 inch.According to an embodiment of the present, the degree of depth that applicator chamber has is enough to guarantee that the applicator being positioned at applicator intracavity makes biological barrier move to approximate 0.010 inch of tissue cavity.According to an embodiment of the present, the degree of depth that applicator chamber has is enough to receive and engage applicator so that the distal contact tissue biological barrier of applicator, thus between the far-end and tissue biological's barrier of applicator, produces interference engagement when assembling in tissue cavity.According to an embodiment of the present, tissue biological's barrier is flexible.According to an embodiment of the present, tissue biological's barrier is film.According to an embodiment of the present, tissue biological's barrier has the thickness between 0.0001 inch to approximate 0.030 inch.According to an embodiment of the present, tissue biological's barrier has the thickness of approximate 0.0005 inch.According to an embodiment of the present, vacuum loop comprises: main vacuum passage, and main vacuum passage flows with applicator chamber and is communicated with; All to flow the vacuum ports be communicated with main vacuum passage and tissue cavity.According to an embodiment of the present, vacuum loop also comprises: to flow the vacuum coupling be communicated with main vacuum passage; Applicator biological barrier between main vacuum passage and applicator chamber.According to an embodiment of the present, applicator biological barrier is positioned at the first side of disposable medical equipment, and vacuum coupling is positioned at the second side of disposable medical equipment.According to an embodiment of the present, main vacuum passage is included in the circuitous path between vacuum coupling and applicator biological barrier.According to an embodiment of the present, main vacuum passage also comprises the vacuum barrier be positioned near applicator biological barrier.According to an embodiment of the present, the main vacuum passage between vacuum ports contact vacuum coupling and vacuum barrier.
According to an embodiment of the present, the present invention includes the method for the vacuum pressure in balance medical treatment device, its medical device comprises applicator and disposable device, described disposable device comprises the tissue cavity and applicator chamber of being separated by flexible tissue biological barrier, and described method comprises the steps: applicator to be placed on applicator intracavity so that applicator sealing applicator chamber opening; Tissue is placed near tissue cavity to organize seal tissue chamber opening at least in part; From tissue cavity's withdrawing air; And from applicator chamber withdrawing air.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device, the method also comprises the steps: applicator to be placed on applicator intracavity so that the far-end of applicator and tissue biological's barrier form interference engagement.According to an embodiment of the present, the method for the vacuum pressure balanced in medical treatment device also comprises the steps: applicator to be placed on applicator intracavity so that tissue biological's barrier is stretched in tissue cavity by the far-end of applicator.According to an embodiment of the present, the method for the vacuum pressure balanced in medical treatment device also comprises the steps: tissue biological's barrier to be stretched to the distance in tissue cavity between approximate 0.001 inch to approximate 0.030 inch.According to an embodiment of the present, the method for the vacuum pressure balanced in medical treatment device also comprises the steps: tissue biological's barrier to be stretched to the distance of in tissue cavity approximate 0.010 inch.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device, wherein comprises the step by biological barrier withdrawing air from the step of applicator chamber withdrawing air.
According to an embodiment of the present, use the method producing damage in the region of the skin histology of medical treatment device below the first area of corium, wherein said medical treatment device comprises applicator and disposable device, this applicator comprises coldplate, this disposable device comprises the tissue cavity and applicator chamber of being separated by flexible tissue biological barrier, and described method comprises the steps: applicator to be placed on applicator intracavity so that applicator sealing applicator chamber opening; Skin histology is placed near tissue cavity to organize seal tissue chamber opening at least in part; From tissue cavity's withdrawing air; From applicator chamber withdrawing air tissue is drawn in applicator intracavity; Propagate electromagnetic energy by coldplate and tissue biological's barrier.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device, the method also comprises the steps: applicator to be placed on applicator intracavity so that the far-end of applicator and tissue biological's barrier form interference engagement.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device, the method also comprises the steps: applicator to be placed on applicator intracavity so that tissue biological's barrier is stretched in tissue cavity by the far-end of applicator.According to an embodiment of the present, the method for the vacuum pressure balanced in medical treatment device also comprises the steps: tissue biological's barrier to be stretched to the distance in tissue cavity between approximate 0.001 inch to approximate 0.030 inch.According to an embodiment of the present, the method for the vacuum pressure balanced in medical treatment device also comprises the steps: tissue biological's barrier to be stretched to the distance of in tissue cavity approximate 0.010 inch.According to an embodiment of the present, the method for the vacuum pressure balanced in medical treatment device also comprises the steps: applicator to be placed on applicator intracavity so that the far-end of applicator and tissue biological's barrier form interference engagement.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device, wherein comprises the step by biological barrier withdrawing air from the step of applicator chamber withdrawing air.
According to an embodiment of the present, describe energy transmission applicator, it comprises: at the disposable interface of applicator far-end, and this disposable interface comprises disposable engaging mechanism; Antenna structure, it comprises at least one the antenna hole of the far-end Propagation of Energy be configured to by applicator; And comprise the cooling circuit of coldplate, wherein cooling circuit be placed between antenna and the far-end of applicator at least partially.According to an embodiment of the present, described antenna comprises: multiple antenna; Be arranged to the distribution member to multiple antenna propagation energy.According to an embodiment of the present, distribution member comprises microwave switch.According to an embodiment of the present, distribution member comprises power divider.According to an embodiment of the present, energy transmission applicator also comprises the dispersing element between hole and applicator far-end.According to an embodiment of the present, cooling circuit also comprises the cooling chamber between antenna hole and the proximal lateral of coldplate.According to an embodiment of the present, cooling circuit at least partially between antenna and the far-end of applicator.According to an embodiment of the present, waveguide assemblies comprises: the multiple radiating guides being positioned at antenna holder; Be arranged to the distribution member to multiple antenna propagation energy.According to an embodiment of the present, distribution member comprises microwave switch.According to an embodiment of the present, distribution member comprises power divider.According to an embodiment of the present, energy transmission applicator also comprises the multiple dispersing elements between hole and applicator far-end.According to an embodiment of the present, cooling circuit also comprises the cooling chamber between antenna hole and the proximal lateral of coldplate.According to an embodiment of the present, waveguide assemblies comprises: the multiple radiating guides being positioned at antenna holder; Be arranged to the distribution member to multiple antenna propagation energy.According to an embodiment of the present, cooling circuit is also included in the cooling channel in antenna holder, and cooling channel is connected to cooling chamber.According to an embodiment of the present, waveguide assemblies comprises: multiple radiating guide; And the multiple isolated components between antenna.According to an embodiment of the present, waveguide assemblies also comprises first isolated component at the first end place being positioned at waveguide assemblies and is positioned at second isolated component at the second end place of waveguide assemblies.According to an embodiment of the present, isolated component comprises the pad of microwave absorbing material.According to an embodiment of the present, isolated component comprises microwave choke.According to an embodiment of the present, radiating guide comprises: inner dielectric piece; At the shell of all gussets except hole around inner dielectric piece.According to an embodiment of the present, coldplate comprises: proximal end face; Distal surface; One or more thermocouple groove in distal surface; And be positioned at one or more thermocouple of thermocouple groove.According to an embodiment of the present, thermocouple groove is configured to be parallel to the E-field of being launched by waveguide assemblies when the energy propagated is microwave energy.According to an embodiment of the present, microwave energy is propagated with TE10 pattern.
According to an embodiment of the present, describe the method using energy transmission applicator cools tissue, this energy transmission applicator comprises antenna hole and coldplate, this coldplate has proximal end face and distal surface and is placed in the far-end of energy transmission applicator, and antenna hole is adjacent to coldplate to be placed in energy transmission applicator, the method comprises the steps: to make to organize in the energy transmission applicator that is bonded near coldplate; Apply energy to tissue, this energy is through coldplate; And cooling fluid is passed through between antenna hole and the proximal end face of coldplate.
According to an embodiment of the present, describe the method for distributing electromagnetic energy to tissue, the method comprises the steps: from antenna hole emittance; Emittance is by cooling fluid, and wherein cooling fluid flows through the cooling chamber below hole; Emittance is through being positioned at the dispersing element of cooling chamber; Emittance is by being positioned at the coldplate on hole opposite; Emittance is by tissue biological's barrier of coldplate distal side.
According to an embodiment of the present, describe the method to aerial array supplying energy, the method comprises the steps: the switch supply electromagnetic energy to being positioned at applicator, and wherein this switch is connected to one or more radiating guide; In scheduled time slot by switch to first wave guide antenna provision electromagnetic energy; Applicator is not reorientated by switch to Second Wave lead antenna supply electromagnetic energy in scheduled time slot.According to an embodiment of the present, to the method for aerial array supplying energy, wherein the first and second radiating guides are adjacent one another are.According to an embodiment of the present, describe the method to aerial array supplying energy, the method comprises the steps: the applicator supply electromagnetic energy to comprising power divider, and wherein power divider is connected to one or more radiating guide; Power divider is connected to continuously at least two in one or more radiating guide described; Do not reorientate applicator; The energy supply to individual antenna is kept in scheduled time slot.
According to an embodiment of the present, describe the microwave links control circuit used in medical treatment device microwave generator, this control circuit comprises: the directional coupler being coupled to the output of microwave links; Be coupled to the power detector of directional coupler, this power detector comprises forward power detector and reverse power detector, and power detector comprises attenuator and detector diode; Be coupled to the forward power look-up table of forward power detector, this forward lookup table comprises the data be associated with the feature of forward power detector; Be coupled to the reverse power look-up table of reverse power detector, this reverse power look-up table comprises the data be associated with the feature of reverse power detector; Be coupled to the duty factor circuit of forward power look-up table, wherein this duty factor circuit is coupled to the switch in microwave links, and this switch is suitable for the duty factor of the input signal of the amplifier controlled in microwave links.
According to an embodiment of the present, describe the method controlled from the output of the microwave links in medical treatment device microwave generator, the method comprises the steps: the forward power signal of the output detecting microwave links; Forward power signal be fed in forward power look-up table, this forward power look-up table comprises the related data of the electrical feature based on forward power detector; According to relevant data modifications forward power signal; Amended forward power signal is fed to duty factor circuit, and wherein this duty factor circuit is suitable for the duty factor of the input signal of the amplifier controlled in microwave links.
According to an embodiment of the present, describe patient support apparatus, it comprises: center support; Be connected to the first and second arm support members of core with the first predetermined angle, wherein said first predetermined angle is between approximate 15 degree to approximate 35 degree.According to an embodiment of the present, the first predetermined angle is approximate 25 degree.
According to an embodiment of the present, describe treatment model, it comprises: flexible and transparent substrate, and this flexible and transparent substrate comprises: be printed on one or more area for treatment profile suprabasil; Be printed on suprabasil multiple equidistant fix position; Be printed on suprabasil multiple model location to indicate; Be printed on suprabasil multiple applicator and place sign.
According to an embodiment of the present, describe the method for hyperhidrosis in treatment patient body, it comprises: patient be placed on patient support apparatus; Treatment model is aligned in the boundary mark on patient's axillary fossa; Patient's axillary fossa marks fix position; Patient's axillary fossa marks applicator position point; Applicator is made to be aligned in applicator position point; Cooling is applied to patient's axillary fossa; Energy is applied to patient's axillary fossa; Make energy conversion by the multiple antennas in applicator; Remove applicator and use alignment mark that applicator is moved to the second therapentic part.
Describe that to be looked at as be only description to the principle of the invention above.In addition, because those skilled in the art can easily recognize a large amount of modification and change, so do not wish to limit the invention to shown and described precision architecture and operation.Although describe preferred embodiment, but do not deviating from situation of the present invention defined by the claims and can change details.
Claims (17)
1. an energy transmission system, comprising:
Energy transmission applicator (2320);
Be positioned at the disposable interface of described applicator far-end, described disposable interface comprises:
Be positioned at the tissue cavity (2338) of the far-end of described disposable medical device (2363), described tissue cavity (2338) comprises the compliant member (2375) being positioned at its far-end, to provide the sealing between skin and described tissue cavity (2338) around the outward flange that described compliant member (2375) is positioned at tissue cavity (2338);
Be positioned at the applicator chamber (2346) of the near-end of described disposable medical equipment (2363);
Connect the vacuum loop (2341) in described tissue cavity (2338) and described applicator chamber (2346), described vacuum loop (2341) is connected to vacuum pressure source;
The flexible membrane of formative tissue biological barrier (2337), described tissue cavity (2338) and described applicator chamber (2346) separate by described tissue biological barrier (2337), and described tissue biological barrier (2337) is the dielectric material that can pass through microwave energy;
Form the film filter of applicator biological barrier (2332), described applicator biological barrier (2332) is arranged in the vacuum loop (2341) between described tissue cavity (2338) and described applicator chamber (2346), with the vacuum pressure in balanced tissue cavity (2338) and applicator chamber (2346); And
Be positioned at the vacuum seal (2348) of the near-end of described applicator chamber (2346), when applicator (2320) is arranged in described applicator chamber (2346), described vacuum seal (2348) is oriented to seal described applicator chamber (2346),
Antenna structure (2364), it comprises at least one the antenna hole of the described far-end Propagation of Energy be configured to by described applicator, and
Comprise the cooling circuit (2376) of coldplate (2340), being placed at least partially between described antenna and the described far-end of described applicator of wherein said cooling circuit.
2. energy transmission system according to claim 1, wherein said antenna comprises:
Multiple antenna;
Be configured to the distribution member (2357) to energy described in described multiple antenna propagation.
3. energy transmission system according to claim 2, wherein said distribution member comprises microwave switch (2357).
4. energy transmission system according to claim 2, wherein said distribution member comprises power divider (2357).
5. energy transmission system according to claim 1, wherein said energy transmission allotter also comprises:
Dispersing element (2378) between described hole and the described far-end of described applicator.
6. energy transmission system according to claim 1, wherein said cooling circuit also comprises:
Cooling chamber (2360) between described antenna hole and the proximal lateral of described coldplate.
7. energy transmission system according to claim 1, wherein said antenna structure comprises waveguide assemblies (2358), and described waveguide assemblies comprises multiple antenna holes of the described far-end Propagation of Energy be configured to by described applicator.
8. energy transmission system according to claim 7, wherein said waveguide assemblies comprises:
Be positioned at multiple radiating guides (2364) of antenna holder (2374);
Be configured to the distribution member to energy described in described multiple antenna propagation.
9. energy transmission system according to claim 8, wherein said distribution member comprises microwave switch.
10. energy transmission system according to claim 8, wherein said distribution member comprises power divider.
11. energy transmission systems according to claim 7, wherein said energy transmission applicator also comprises:
Multiple dispersing elements between described hole and the described far-end of described applicator.
12. energy transmission systems according to claim 7, wherein said cooling circuit also comprises the cooling chamber between described antenna hole and the proximal lateral of described coldplate.
13. energy transmission systems according to claim 12, wherein said waveguide assemblies comprises:
Be positioned at multiple radiating guides of antenna holder;
Be configured to the distribution member to energy described in described multiple antenna propagation.
14. energy transmission systems according to claim 13, wherein said cooling circuit is also included in the cooling channel in described antenna holder, and described cooling channel is connected to described cooling chamber.
15. energy transmission systems according to claim 7, wherein said coldplate comprises:
Proximal end face;
Distal surface;
One or more thermocouple groove in described distal surface; And
Be positioned at one or more thermocouple of described thermocouple groove.
16. energy transmission systems according to claim 15, wherein said thermocouple groove is configured to be parallel to the E-field of being launched by described waveguide assemblies when the energy of described propagation is microwave energy.
17. energy transmission systems according to claim 16, wherein said microwave energy is with TE
10pattern is propagated.
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1327407P | 2007-12-12 | 2007-12-12 | |
| US61/013274 | 2007-12-12 | ||
| US4593708P | 2008-04-17 | 2008-04-17 | |
| US61/045937 | 2008-04-17 | ||
| PCT/US2008/060935 WO2008131302A2 (en) | 2007-04-19 | 2008-04-18 | Methods and apparatus for reducing sweat production |
| USPCT/US08/60922 | 2008-04-18 | ||
| USPCT/US08/60940 | 2008-04-18 | ||
| PCT/US2008/060922 WO2009075903A1 (en) | 2007-04-19 | 2008-04-18 | Systems and methods for creating an effect using microwave energy to specified tissue |
| PCT/US2008/060940 WO2008131306A1 (en) | 2007-04-19 | 2008-04-18 | Systems and methods for creating an effect using microwave energy to specified tissue |
| PCT/US2008/060929 WO2009075904A1 (en) | 2007-04-19 | 2008-04-18 | Methods, devices, and systems for non-invasive delivery of microwave therapy |
| USPCT/US08/60929 | 2008-04-18 | ||
| USPCT/US08/60935 | 2008-04-18 | ||
| US12/107,025 US9427285B2 (en) | 2007-04-19 | 2008-04-21 | Systems and methods for creating an effect using microwave energy to specified tissue |
| US12/107025 | 2008-04-21 | ||
| US19694808P | 2008-10-22 | 2008-10-22 | |
| US61/196948 | 2008-10-22 | ||
| CN200880126637.8A CN101970046B (en) | 2007-12-12 | 2008-12-12 | Disposable medical equipment and system thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880126637.8A Division CN101970046B (en) | 2007-12-12 | 2008-12-12 | Disposable medical equipment and system thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104707263A true CN104707263A (en) | 2015-06-17 |
| CN104707263B CN104707263B (en) | 2017-09-12 |
Family
ID=48014608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510013609.7A Active CN104707263B (en) | 2007-12-12 | 2008-12-12 | Energy transmission system |
Country Status (3)
| Country | Link |
|---|---|
| JP (3) | JP5978245B2 (en) |
| CN (1) | CN104707263B (en) |
| SG (1) | SG186642A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821493A (en) * | 2017-03-24 | 2017-06-13 | 深圳半岛医疗有限公司 | Microneedle theraphy head and microneedle theraphy device |
| CN108348757A (en) * | 2015-09-09 | 2018-07-31 | Cpg技术有限责任公司 | Medical Devices inside electric power with the surface wave being guided |
| CN111031932A (en) * | 2017-08-31 | 2020-04-17 | 史密夫和内修有限公司 | Computer controlled remote power module for use with battery controlled surgical tools |
| CN112168334A (en) * | 2019-01-30 | 2021-01-05 | 苏州信迈医疗器械有限公司 | Radio frequency ablation instrument with temperature dynamic smoothing function |
| CN112244993A (en) * | 2020-10-31 | 2021-01-22 | 杭州诺生医疗科技有限公司 | Radio frequency ablation instrument |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197860A (en) * | 1977-11-21 | 1980-04-15 | Rca Corporation | Hyperthermia applicator |
| JPS62149347U (en) * | 1986-03-13 | 1987-09-21 | ||
| BR9305925A (en) * | 1992-02-20 | 1997-08-26 | Humanteknik Ab | Device for vacuum affixing an object to a surface electrode unit and absorber for a vacuum electrode assembly |
| EP0597463A3 (en) * | 1992-11-13 | 1996-11-06 | Dornier Med Systems Inc | Thermotherapiesonde. |
| US6104959A (en) * | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
| GB0425765D0 (en) * | 2004-11-23 | 2004-12-22 | Gyrus Medical Ltd | Tissue resurfacing |
| US20030181890A1 (en) * | 2002-03-22 | 2003-09-25 | Schulze Dale R. | Medical device that removably attaches to a bodily organ |
| GB2387544B (en) * | 2002-10-10 | 2004-03-17 | Microsulis Plc | Microwave applicator |
| JP2008501441A (en) * | 2004-06-07 | 2008-01-24 | エドワーズ ライフサイエンシーズ コーポレイション | Method and device for directional resection of tissue |
| JP2006289098A (en) * | 2005-04-12 | 2006-10-26 | Inolase 2002 Ltd | Apparatus for vacuum-assisted light-based treatment of skin |
-
2008
- 2008-12-12 SG SG2012090429A patent/SG186642A1/en unknown
- 2008-12-12 CN CN201510013609.7A patent/CN104707263B/en active Active
-
2014
- 2014-05-07 JP JP2014095998A patent/JP5978245B2/en active Active
-
2016
- 2016-07-25 JP JP2016145299A patent/JP6320470B2/en active Active
-
2018
- 2018-04-03 JP JP2018071617A patent/JP2018140185A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108348757A (en) * | 2015-09-09 | 2018-07-31 | Cpg技术有限责任公司 | Medical Devices inside electric power with the surface wave being guided |
| CN106821493A (en) * | 2017-03-24 | 2017-06-13 | 深圳半岛医疗有限公司 | Microneedle theraphy head and microneedle theraphy device |
| CN106821493B (en) * | 2017-03-24 | 2024-02-27 | 深圳半岛医疗集团股份有限公司 | Microneedle therapy head and microneedle therapy apparatus |
| CN111031932A (en) * | 2017-08-31 | 2020-04-17 | 史密夫和内修有限公司 | Computer controlled remote power module for use with battery controlled surgical tools |
| CN111031932B (en) * | 2017-08-31 | 2023-09-29 | 史密夫和内修有限公司 | Computer controlled remote power module for use with battery controlled surgical tools |
| CN112168334A (en) * | 2019-01-30 | 2021-01-05 | 苏州信迈医疗器械有限公司 | Radio frequency ablation instrument with temperature dynamic smoothing function |
| CN112168335A (en) * | 2019-01-30 | 2021-01-05 | 苏州信迈医疗器械有限公司 | Radio frequency ablation instrument with repeated ablation prevention function |
| CN112168334B (en) * | 2019-01-30 | 2021-12-03 | 苏州信迈医疗器械有限公司 | Radio frequency ablation instrument with temperature dynamic smoothing function |
| CN112244993A (en) * | 2020-10-31 | 2021-01-22 | 杭州诺生医疗科技有限公司 | Radio frequency ablation instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6320470B2 (en) | 2018-05-09 |
| JP5978245B2 (en) | 2016-08-24 |
| SG186642A1 (en) | 2013-01-30 |
| JP2018140185A (en) | 2018-09-13 |
| CN104707263B (en) | 2017-09-12 |
| JP2016185400A (en) | 2016-10-27 |
| JP2014184317A (en) | 2014-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101970046B (en) | Disposable medical equipment and system thereof | |
| US8825176B2 (en) | Apparatus for the noninvasive treatment of tissue using microwave energy | |
| US10779887B2 (en) | Systems and methods for creating an effect using microwave energy to specified tissue | |
| US20100211059A1 (en) | Systems and methods for creating an effect using microwave energy to specified tissue | |
| JP6320470B2 (en) | System, apparatus method, and procedure for non-invasive tissue treatment using microwave energy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: California, USA Patentee after: Beautiful net Co. Address before: California, USA Patentee before: Beautiful China Technology Co. Address after: California, USA Patentee after: Beautiful China Technology Co. Address before: California, USA Patentee before: Miramar Labs, Inc. |
|
| CP01 | Change in the name or title of a patent holder |