CN104707182A - Intervertebral implant - Google Patents
Intervertebral implant Download PDFInfo
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- CN104707182A CN104707182A CN201310696169.0A CN201310696169A CN104707182A CN 104707182 A CN104707182 A CN 104707182A CN 201310696169 A CN201310696169 A CN 201310696169A CN 104707182 A CN104707182 A CN 104707182A
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- intervertebral implant
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- biological material
- powder
- degradable biological
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Abstract
The invention relates to an intervertebral implant, especially to an intervertebral implant that utilizes porous hydroxyapatite as the scaffold model filled with metal powder and undergoes sintering shaping to compose a locally degradable hydroxyapatite/metal bulk. The hydroxyapatit structure degrades gradually along with the time of implantation into the human body, and bone tissues guided to attach to the inside of porous metals so as to form a steady upper bone and lower bone fusion effect.
Description
Technical field
The present invention relates to a kind of medical implant technical field, specifically refer to a kind of local degradable and in the intervertebral implant of porous kenel, use composition local degradable oxyhydrogen-base apatite and metal mixed bulk, thus Guided Bone Regeneration and form the effect of firm upper and lower part bone fusion.
Background technology
Press, lumbar intervertebral fusion, mean to take out intervertebral disc from two joint vertebras, then the two is merged.This step has another name called for " spinal fusion ".Be generally used for treating the aching and limp sufferer such as unable of the persistent back pain, sciatica or the both legs that are caused by rachiopathys such as vertebra degeneration, intervertebral disk hernia.Spinal fusion is also the wherein important step that rectification deformity of spine (as scoliosis, spondylolysis or spinal trauma etc.) is performed the operation.
If implantation body's (or in order to repair the implant of osseous tissue) of repairing osseous tissue is biological absorbable while providing support function, practical application has great benefit.Existing spinal fusion device is made up of a metallic framework and the bioabsorbable material put in the inner, such as U.S. Patent number 5,645, the device shown in 598.Only, those are placed between two joint vertebraes in order to the planting system repairing osseous tissue, but and relative volume not enough for fear of the hardness of this implantation body own is less than this vertebrae, this implantation body is caused to produce sinkage, wearing and tearing even destroy the osseous tissue between vertebrae and vertebrae mutually on the contrary, particularly bring grievous injury especially to the end plane of vertebrae.
Separately, the structure that the support (major part is made up of biodegradable polymer) learned a skill for organizational project at present has porous can allow active somatic cell in cell cultivation process (usually taking from the patient in treatment) to infiltrate in structure.Through cell culture after a while, this kind has in the immune animal of the implanted removal of the support of cell (such as rat) or sufferers themselves's body (for ease of subsequent operation normally subcutaneous).The nutritional labeling provided in (several weeks are to the several months) Cell uptake animal or patient body during this period and breeding rapidly, support itself solution absorption gradually simultaneously.Afterwards, just from the subcutaneous taking-up implantation body of animal or patient (one real osseous tissue), (the injured or ill) position needing treatment is again implanted.Such as US6,139,578; US6,200,606; US5, the case one depicted such as 306,303 and US6,132,463.
But, if for tissue engineering technique support can by bio-absorbable, have sufficient hole can provide support again simultaneously, so such material just has an enormous advantage.Wherein as Chinese patent CN119346A: a kind of porous calcium phosphate bone cement containing pore former, it is characterized in that being made up of the calcium phosphate bone cement of routine and pore former, said pore former is one or more in slightly soluble salt, acid salt and basic salt or surfactant.But it is that its bad mechanical strength, cannot be used alone as bone fusions without fixing kenel bone cement.
And for example Chinese patent CN101099873A: a kind of manufacturing technique method of porous magnesium/hydroxyapatite, it is characterized in that hydroxylapatite powder and magnesium powder to be mixed in proportion, cold moudling, then sinters, magnesium is at high temperature vaporized, evaporated, and makes hydroxyapatite form cellular.After only magnesium high temperature removes, only surplus porous oxyhydrogen-base apatite body, equally has the problem of bad mechanical strength.
For another Chinese patent CN101797400A: a kind of containing HA how rice flour porous degradable magnesium alloy bone scaffold material, it is characterized in that, described porous degradable magnesium alloy bone scaffold material is by adding the magnesium powder of micro-refinement Zn crystal grain, HA how rice flour, and pore creating material composition, interim, how rice flour is 10 ~ 20% to magnesium-zinc alloy powder micro-50 ~ 80%, HA, and pore creating material forms, wherein, how rice flour is 10 ~ 20% to magnesium-zinc alloy powder micro-50 ~ 80%, HA, and pore creating material is 10 ~ 30%.After only magnesium high temperature removes, only surplus porous oxyhydrogen-base apatite body, equally has the problem of bad mechanical strength.
Moreover poroid hydroxyapatite (HA) material that conventional high temperature (usual >1000 DEG C) sinters does not possess the hole of enough micrometer/nanometer levels and is difficult to be absorbed by organism.On the other hand, the conventional biodegradable polymers being used for skeleton has again the shortcoming that intensity is relatively low and rate of dissolution is too high.In other words before considering lightweight, increasing biological combination, under topic, be necessary that development can promote the connected porous metal doctor material of bone guided.
Inventor in view of above-mentioned known promotion bone guided connected porous metal doctor material every shortcoming of derive, be urgently think to be improved innovation, finally successfully researched and developed this part one intervertebral implant.
Summary of the invention
Namely the object of the present invention is to provide a kind of intervertebral implant, use the intervertebral implant that can form the degradable oxyhydrogen-base apatite/metal block material in local, progressively degrade with implant into body time oxyhydrogen-base apatite structure, and inducting osseous tissue is sought connections with in porous metals inner, forms firm top and bottom bone syncretizing effect.
A time object of the present invention is to provide a kind of intervertebral implant, for using degradable high polymer material or the complex of ceramic material or metal material, manufacture and design the material with excellent properties and structure according to bionic principle, and there is the degradation rate regulating material.
Another object of the present invention is that providing a kind of possesses the biological behaviour of cell and the timbering material of culture efficiency, can have the intervertebral implant of good adaptation, combination and reparation after intervertebral implant is transplanted with body cavity hole.
The another object of the present invention is to provide a kind of intervertebral implant with good bio-compatibility, possesses no cytotoxicity, can not cause the advantage of the rejection of human bone time in implant into body when this intervertebral implant is cultivated in vitro.
An object again of the present invention is to provide a kind of intervertebral implant, this intervertebral implant has 3-D solid structure, and there is highly porous shape structure, this intervertebral implant has very large internal surface area, to be conducive to implantation, the adhesion of cell, be conducive to again the infiltration of cytotrophy composition and the discharge of metabolite.
His object of the present invention is to provide a kind of intervertebral implant, and this intervertebral implant has good surface activity, can promote the adhesion of cell and provide good microenvironment in the propagation on its surface for cell.
A kind of intervertebral implant of foregoing invention object can be reached, insert after metal-powder through thermal sintering for stent model for utilizing porous oxyhydrogen-base apatite, the intervertebral implant of the oxyhydrogen-base apatite/metal block material of composition local degradable, its preparation method, comprises the steps:
Step a, mixing: degradable biological material and the adhesive liquid that can produce Degradation in human body stir, and form a kind of micro-thick liquid;
Step b, be stained with and cover: be stained with to be covered with porous polymeric stent and state micro-thick liquid, make to be coated with this micro-thick liquid in the space of this polymeric stent surface and/or its hole, chamber shape;
Step c, drying and shaping: and complete be stained with cover after dry, micro-thick liquid is made to be coated in polymeric stent and hole, chamber shape closely spatially, and arrange different according to polymeric stent from Dong Zhuan space, chamber original porous, be closely coated in top layer and present identical porous arrangement;
Steps d, sintering remove: carry out high temperature sintering with air body of heater, and polymeric stent and adhesive are removed, to obtain a degradable biological material support of porous arrangement; And
Step e, fill around knot: utilize this degradable biological material support to insert metal-powder for stent model, and carry out vacuum high-temperature sintering, to obtain by a degradable biological material intervertebral implant mutually chimeric with metal-powder.
By this, through the specific implementation of above-mentioned technological means, make the present invention can pass through oxyhydrogen-base apatite biomaterial and there is good biological compatibility, bone conductibility and biological degradability, can occur gradually after in the intervertebral implant of oxyhydrogen-base apatite/metal block material to dissolve and biodegradation, after certain hour, lifeless oxyhydrogen-base apatite intervertebral implant dissolves disappearance gradually, replace by lived freshman bone tissue, also the hole, intervertebral implant implant into body chamber of oxyhydrogen-base apatite/metal block material is used, after in the hole, intervertebral implant implant into body chamber of oxyhydrogen-base apatite/metal block material, inducting osseous tissue is grown into Dong Zhuan space, chamber gradually, stop growing into of soft tissue simultaneously, thus the intervertebral implant realizing oxyhydrogen-base apatite/metal block material firmly mechanical bond in human bone, and effectively can increase the surcharge of product, and promote its economic benefit.
Accompanying drawing explanation
Fig. 1 is the concise and to the point schematic flow sheet of a kind of intervertebral implant of the present invention;
Fig. 2 is that the step of this kind of intervertebral implant makes schematic diagram;
Adnexa 1 ~ adnexa 4 is divided for cell and is shown in porous metal structure surface the action diagram being all normal condition cell behavior.
Detailed description of the invention
Refer to Fig. 1, a kind of intervertebral implant provided by the present invention, it is jointly made up of metal-powder and degradable biological material; Wherein, this degradable biological material has plural intercommunicating pore through sintering, and this metal-powder is then filled in this plural intercommunicating pore, and mutually chimeric with this degradable biological material through sintering.By this, degradable biological material contained by this intervertebral implant dissolves and cell-mediated biodegradation by body fluid then, a part participates in osseous tissue and implants local or the reconstruction of long-range osseous tissue, another part is excreted by metabolic system gradually, defect is finally made to be substituted by the osseous tissue of new life completely, and this metal rack plays permanent support effect simultaneously, i.e. bone tissue engineering stent material.Based on this, this degradable biological material also can be selected replaced by absorbable biological material, to reach effect as previously mentioned according to principle of identity.
Continuous ginseng Fig. 1 and 2, this intervertebral implant is made up of the following step, comprise: step a, mixing: degradable biological material and the adhesive liquid that can produce Degradation in human body stir, its whipping temp 1100 ~ 1300 DEG C, the time of being uniformly mixed is 10 ~ 60min, and forms a kind of micro-thick liquid; Wherein, this degradable biological material can be chosen as oxyhydrogen-base apatite, and this adhesive then can be chosen as polyvinyl acetate (also referred to as polyvinyl acetate, be called for short PVA, PVAc), it belongs to a kind of resilient synthetic polymer, preferably, the present embodiment system mixes polyvinyl acetate by oxyhydrogen-base apatite, to form oxyhydrogen-base apatite/PVA slurry as shown in Figure 2;
Step b, be stained with and cover: carry out being stained with the polymeric stent of porous (high-molecular support) and above-mentioned micro-thick liquid and cover operation and be coated with this micro-thick liquid in the space of polymeric stent surface and/or hole, chamber shape; Wherein this polymeric stent is made by ceramic material or metal material, and its polymeric stent all as shown in Figure 2 has Dong Zhuan space, plural chamber;
Step c, drying and shaping: and complete be stained with cover after dry in baking oven, bake out temperature 50 ~ 100 DEG C, the drying and shaping time is 8 ~ 24hr, make micro-thick liquid be coated in closely polymeric stent surface and/or hole, chamber shape spatially, and according to polymeric stent and/or Dong Zhuan space, chamber original porous arrangement difference, be closely coated in top layer and present the arrangement of identical porous; Preferably, after the present embodiment attaches oxyhydrogen-base apatite/PVA slurry with this polymeric stent, is make all to be coated with aforementioned slurry in this polymeric stent surface and Dong Zhuan space, chamber thereof, and the arrangement in porous kenel;
Steps d, sintering remove: carry out high temperature sintering with air body of heater, high temperature sintering temperature 1100 ~ 1300 DEG C, and polymeric stent and adhesive are removed, and then obtain the degradable biological material support of porous arrangement, join Fig. 2 in detail; And
Step e, fill around knot: utilize the biological material support of porous, degradable to insert metal-powder for stent model (support mountingmodel), wherein the stent model of this degradable biological material support can be intercommunicating pore stereochemical structure, and the wire diameter structure width of the stent model of this degradable biological material support is 10 μm ~ 200 μm, and the titanium that the optional self energy of metal-powder is prepared in thermal sintering mode, titanium alloy, zirconium, zircaloy, tantalum, more than the one of tantalum alloy or one mix, and after metal-powder sintering, it presents homogeneous metal ball body structure size, and be equal to and do not sinter front metal-powder particle diameter, metal-powder particle diameter is between 10 μm ~ 100 μm again, insert after this polymeric stent until metal-powder, carry out vacuum high-temperature sintering thereupon, vacuum high-temperature sintering temperature comparatively family is controlled in 1100 ~ 1300 DEG C, and the drying and shaping time is 1 ~ 3h, to obtain this degradable biological material this intervertebral implant mutually chimeric with metal-powder, preferably, the present embodiment system obtains the monolithic structure (namely the one local degradable of drawing guides the porous metal structure of stock regeneration) that jointly can sinter as the oxyhydrogen-base apatite of Fig. 2 and metal, and this bulk is the intervertebral implant in porous kenel of the present invention.
By this, to grow into Dong Zhuan space, chamber gradually to osseous tissue after ensureing intervertebral implant and implanting in the hole, intervertebral implant implant into body chamber that can obtain oxyhydrogen-base apatite/metal block material through above-mentioned preparation method, wherein oxyhydrogen-base apatite is implanted in the material for degradable in human body, the structure of matter in oxyhydrogen-base apatite material is the key factor determining its biological degradability, the calcium phosphorus ratio (Ca/P) of oxyhydrogen-base apatite is 1.65 ~ 1.75, apatite (apatite) structure of matter is still kept after sintering, bone guided effect is produced in new bone formation process, slowly degrade by the increase of Implantation Time, it is at a slow speed in degradation process, bone guided effect that oxyhydrogen-base apatite is outstanding can be utilized, the intervertebral implant guiding new bone tissue to enter oxyhydrogen-base apatite/metal block material from host bone along the intervertebral implant of oxyhydrogen-base apatite/metal block material is inner, reach top and the firm effect healing and realize that firmly machinery is fixing of inferior bone tissue.
In sum, through aforesaid structural design, the present invention can prepare a kind of porous metal structure, use the intervertebral implant of the oxyhydrogen-base apatite/metal block material that can form local degradable, with the time of its implant into body, wherein oxyhydrogen-base apatite structure is progressively degraded, and in degradation process, inducting osseous tissue is sought connections with in porous metal structure inner, make implanting portion form the bone fusion effect of firm top and bottom, make it have the effect changing and increase biological combination easily further.
A kind of intervertebral implant provided by the present invention, with aforementioned quote as proof case and other located by prior art mutually compare time, have more following advantages:
The intervertebral implant of this oxyhydrogen-base apatite/metal block material has biodegradability, and intervertebral implant should be degraded gradually in osseous tissue forming process, and does not affect the 26S Proteasome Structure and Function of newly-generated osseous tissue.
The intervertebral implant of this oxyhydrogen-base apatite/metal block material has plasticity, required shape can be processed to and there is certain mechanical strength, still can keep its shape in certain hour after in intervertebral implant, and make the new tissue formed have the profile meeting design.
Above-listed detailed description system illustrating for one of the present invention possible embodiments, only this embodiment be not used to the scope of the claims limiting the present invention, all do not depart from skill of the present invention spirit institute for it equivalence implement or change, all should be contained in the scope of the claims of this case.
In sum, this case not only really belongs to innovation in the kenel of space, and comparatively can commonly use the above-mentioned multinomial effect of article enhancement, fully should meet the Statutory Invention patent requirement of novelty and progressive, filing an application in whence in accordance with the law, earnestly asks your office and check and approve this part application for a patent for invention case, to encourage invention, to feeling moral just.
Claims (7)
1. an intervertebral implant, is characterized in that: it is jointly made up of metal-powder and degradable biological material;
Wherein, this degradable biological material has plural intercommunicating pore through sintering, and this metal-powder is then filled in this plural intercommunicating pore, and mutually chimeric with this degradable biological material through sintering.
2. intervertebral implant according to claim 1, is characterized in that: this degradable biological material is for oxyhydrogen-base apatite and adhesive are through sintering the stent model formed, and this stent model has this plural intercommunicating pore.
3. intervertebral implant according to claim 2, is characterized in that: the wire diameter structure width of this stent model is 10 μm ~ 200 μm.
4. intervertebral implant according to claim 1, is characterized in that: this metal-powder one of to be selected from titanium, titanium alloy, zirconium, zircaloy, tantalum and tantalum alloy or more than one mixing.
5. intervertebral implant according to claim 1, is characterized in that: this metal-powder presents homogeneous metal ball body structure size after sintering, and is equal to and does not sinter front metal-powder particle diameter, and this metal-powder particle diameter is between 10 μm ~ 100 μm.
6. prepare a method for intervertebral implant as claimed in claim 1, it is characterized in that: the method comprises the steps:
Step a, mixing: degradable biological material and the adhesive liquid that can produce Degradation in human body stir, and form a kind of micro-thick liquid;
Step b, be stained with and cover: be stained with porous polymeric stent and cover described micro-thick liquid, make to be coated with this micro-thick liquid in the space of this polymeric stent surface and/or its hole, chamber shape;
Step c, drying and shaping: and complete be stained with cover after dry, micro-thick liquid is made to be coated in polymeric stent and/or hole, chamber shape closely spatially, and according to polymeric stent and/or Dong Zhuan space, chamber original porous arrangement difference, be closely coated in top layer and present identical porous arrangement;
Steps d, sintering remove: carry out high temperature sintering with air body of heater, and polymeric stent and adhesive are removed, to obtain a degradable biological material support of porous arrangement; And
Step e, fill around knot: utilize this degradable biological material support to insert metal-powder for stent model, and carry out vacuum high-temperature sintering, to obtain by a degradable biological material intervertebral implant mutually chimeric with metal-powder.
7. the method preparing intervertebral implant according to claim 6, it is characterized in that: this degradable biological material is oxyhydrogen-base apatite, the stent model sintered by this oxyhydrogen-base apatite and this adhesive has plural intercommunicating pore, and the wire diameter structure width of this stent model is 10 μm ~ 200 μm.
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| CN201310696169.0A CN104707182B (en) | 2013-12-16 | 2013-12-16 | Intervertebral implant |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310696169.0A CN104707182B (en) | 2013-12-16 | 2013-12-16 | Intervertebral implant |
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| CN104707182A true CN104707182A (en) | 2015-06-17 |
| CN104707182B CN104707182B (en) | 2017-08-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107402373A (en) * | 2016-05-19 | 2017-11-28 | 财团法人金属工业研究发展中心 | Domain type locating module |
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| CN1647778A (en) * | 2004-11-29 | 2005-08-03 | 西安理工大学 | Method for preparing hole structure gradient changing spherical inner hole artificial bone |
| US20080249638A1 (en) * | 2007-04-05 | 2008-10-09 | Cinvention Ag | Biodegradable therapeutic implant for bone or cartilage repair |
| US20100209666A1 (en) * | 2009-02-19 | 2010-08-19 | Kori Rivard | Rough Porous Constructs |
| CN102014798A (en) * | 2008-03-18 | 2011-04-13 | 友和安股份公司 | Composite implant having porous structure filled with biodegradable alloy and method of magnesium-based manufacturing the same |
| CN103357063A (en) * | 2012-04-10 | 2013-10-23 | 中国科学院金属研究所 | Metal composite material capable of inducing bone growth and application thereof |
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2013
- 2013-12-16 CN CN201310696169.0A patent/CN104707182B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1647778A (en) * | 2004-11-29 | 2005-08-03 | 西安理工大学 | Method for preparing hole structure gradient changing spherical inner hole artificial bone |
| US20080249638A1 (en) * | 2007-04-05 | 2008-10-09 | Cinvention Ag | Biodegradable therapeutic implant for bone or cartilage repair |
| CN102014798A (en) * | 2008-03-18 | 2011-04-13 | 友和安股份公司 | Composite implant having porous structure filled with biodegradable alloy and method of magnesium-based manufacturing the same |
| US20100209666A1 (en) * | 2009-02-19 | 2010-08-19 | Kori Rivard | Rough Porous Constructs |
| CN103357063A (en) * | 2012-04-10 | 2013-10-23 | 中国科学院金属研究所 | Metal composite material capable of inducing bone growth and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107402373A (en) * | 2016-05-19 | 2017-11-28 | 财团法人金属工业研究发展中心 | Domain type locating module |
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