CN104694848A - Biodegradable quaternary iron-based alloy material and preparation method thereof - Google Patents
Biodegradable quaternary iron-based alloy material and preparation method thereof Download PDFInfo
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- CN104694848A CN104694848A CN201510042513.3A CN201510042513A CN104694848A CN 104694848 A CN104694848 A CN 104694848A CN 201510042513 A CN201510042513 A CN 201510042513A CN 104694848 A CN104694848 A CN 104694848A
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- 239000000956 alloy Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract description 59
- 229910052742 iron Inorganic materials 0.000 title abstract description 32
- 238000000498 ball milling Methods 0.000 claims abstract description 44
- 239000000843 powder Substances 0.000 claims abstract description 29
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 22
- 238000000227 grinding Methods 0.000 claims abstract description 12
- 229910052751 metal Inorganic materials 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 12
- 239000002184 metal Substances 0.000 claims abstract description 8
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 7
- 229910052755 nonmetal Inorganic materials 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 4
- 229910052709 silver Inorganic materials 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 3
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical group [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 27
- 238000009413 insulation Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 238000000465 moulding Methods 0.000 claims description 11
- 238000005275 alloying Methods 0.000 claims description 7
- 229910045601 alloy Inorganic materials 0.000 abstract description 16
- 238000006731 degradation reaction Methods 0.000 abstract description 12
- 230000015556 catabolic process Effects 0.000 abstract description 10
- 229910052710 silicon Inorganic materials 0.000 abstract description 5
- 229910052717 sulfur Inorganic materials 0.000 abstract description 4
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 229910001092 metal group alloy Inorganic materials 0.000 abstract description 2
- 238000005260 corrosion Methods 0.000 description 19
- 230000007797 corrosion Effects 0.000 description 19
- 239000011572 manganese Substances 0.000 description 12
- 239000011777 magnesium Substances 0.000 description 5
- 229910001566 austenite Inorganic materials 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229910000640 Fe alloy Inorganic materials 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052748 manganese Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229910015136 FeMn Inorganic materials 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910000914 Mn alloy Inorganic materials 0.000 description 1
- 239000010953 base metal Substances 0.000 description 1
- 229910002056 binary alloy Inorganic materials 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- -1 ferrous metals Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910000765 intermetallic Inorganic materials 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229910002058 ternary alloy Inorganic materials 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Abstract
The invention discloses a biodegradable quaternary iron-based alloy material. Chemical components of the biodegradable quaternary iron-based alloy material are as follows: Fe-30Mn-nX-kY, wherein n and k are percentage in mass (wt.%), n is not smaller than 1% and not lager than 3%, 5 is not smaller than 0.05% and not larger than 3%; X is a metal alloy element including one of Mg, Zn and Ag; Y is a nonmetal alloy element including one of C, Si and S. A preparation method for the biodegradable quaternary iron-based alloy material comprises the following steps: mixing metal and nonmetal powder of the components, adding the mixture into a liquid-nitrogen type ball mill to perform ball milling in a ratio of grinding media to material of (20-25) to 1 for 16-24 hours to obtain pre-pressed and pre-formed powder, wherein the rotation speed of the ball mill is 400-450r/min, and the ball mill stops for 30 minutes after operating for 120 minutes every time; preserving the temperature and the pressure for 30-60 minutes under 4-6GPa at 1200-1600 DEG C to synthesize the biodegradable quaternary iron-based alloy material. The biodegradable quaternary iron-based alloy material is simple in preparation process, low in cost, safe and non-toxic and capable of remarkably increasing the degradation rate.
Description
Technical field
The present invention relates to a kind of degradable alloy material and preparation method thereof.
Background technology
At present, study hotter degradable metal material and mainly concentrate on pure magnesium, magnesium-base metal alloy and pure iron, ferrous metals alloy two general orientation.Compared with Magnuminium, pure iron and alloy thereof have excellent mechanical property, and in degradation process, do not have evolving hydrogen reaction to occur.In addition, Fe is also extremely important trace element in human body, and Related Experimental Study shows, pure iron or iron alloy have certain biological safety as implant.Good biocompatibility is also a large advantage of pure iron and alloy thereof, according to some current achievements in research, comprises the extracorporeal blood experiment of pure iron and iron alloy, cytotoxicity experiment and animal experiment in vivo etc., all shows that it has good biocompatibility.
The corrosion degradation process of iron-based biomaterial is subject to various factors, mainly comprises its chemical composition, processing mode, residing environment etc.In the corrosion resistance improving iron and alloy thereof, have a lot of scholar carried out a large amount of research work, and achievement is remarkable, but about reducing the corrosion resistance of iron and alloy thereof, improving the work rare report of its degradation rate.The slower degradation rate of iron is its topmost restriction bottleneck as biodegradable metals material.
In order to improve the degradation rate of pure iron, researchers have carried out a large amount of explorations to be attempted, and the Standard Electrode Potentials of Mn is lower than Fe, and can many investigators be locked in Mn using sight and improve on the degradation rate of Fe as alloying element.As Hermawan H etc. has prepared Fe-(25% ~ 35%) Mn alloy by powder metallurgic method, have studied the impact of alloying on iron first, find that its degradation rate is compared with pure iron slightly to increase, but also have larger distance from the requirement of Clinical practice, the raising of iron-based biomaterial degradation rate also has very large space.
Summary of the invention:
The object of the present invention is to provide that a kind of preparation technology is simple, with short production cycle, safety non-toxic, the biodegradable quaternary ferrous alloy material that can significantly improve degradation rate and preparation method thereof.The present invention mainly passes through in Fe, Mn powder, to add a kind of metallic element and a kind of non-metallic element, compressing tablet after ball milling, the biological alloy of high-pressure synthesis iron-based.
Biodegradable quaternary ferrous alloy material of the present invention, its chemical composition is: Fe-30Mn-nX-kY, n, k are mass percent (wt.%), wherein 1%≤n≤3%, 0.5%≤k≤3%; X is metallic alloying element, comprises the one in Mg, Zn, Ag; Y is non-metallic alloying elements, comprises the one in C, Si, S.Mentioned component is equal >=99.9% metal of purity or non-metal powder.
The preparation method of above-mentioned biodegradable quaternary ferrous alloy material:
By the metal of mentioned component and non-metal powder mixing, add in liquid nitrogen type ball mill by the ratio of grinding media to material of 20 ~ 25:1 and carry out ball milling, rotating speed is 400 ~ 450r/min, often stall 30min after running 120min, ball milling 16 ~ 24h, by the powder pre-molding obtained, then uses six-plane piercer at 4 ~ 6GPa, heat-insulation pressure keeping 30 ~ 60min at 1200 ~ 1600 DEG C, synthesising biological degradable quaternary ferrous alloy material.
Active metal element M g, Zn that the present invention adds, make it solid solution by the mode of ball milling and enter in Fe, reduce the standard potential of Fe, accelerate the corrosion of Fe; The inert metal elements A g added, makes it the intermetallic compound of generation little and homodisperse cathodic process and improves galvanic corrosion; Non-metallic element C, Si, S of adding, be human essential elements, wherein the existence of C element can participate in the phase in version of Fe, and Si can promote the formation of reticular tissue and bone, and S is also one of required major element of health.
The present invention compared with prior art tool has the following advantages:
1, preparation technology is simple, with short production cycle, adopts six-plane piercer high-temperature and high-pressure conditions next time shaping after the pressed powder that ball milling is obtained.
2, safety non-toxic, the alloying element of interpolation is human essential elements, can improve degradation rate, can promote bone growth again, supplements health essential element.
3, compared with FeMn binary alloy and FeMn-x ternary alloy, its degradation rate improves two orders of magnitude, and satisfactory mechanical property.
Accompanying drawing explanation
Fig. 1 is the XRD figure of Fe30Mn3Mg0.5C prepared by the embodiment of the present invention 1.
Fig. 2 is the corrosion electric current density figure of Fe30Mn3Zn0.5Si prepared by the embodiment of the present invention 2.
Fig. 3 is the corrosion electric current density figure of Fe30Mn3Ag 0.5S prepared by the embodiment of the present invention 3.
Fig. 4 is the corrosion electric current density figure of Fe30Mn1Zn3Si prepared by the embodiment of the present invention 4.
Fig. 5 is the corrosion electric current density figure of Fe30Mn1Ag3C prepared by the embodiment of the present invention 5.
Fig. 6 is the optical electron microscope figure of Fe30Mn1Mg3S prepared by the embodiment of the present invention 6.
Fig. 7 is the corrosion electric current density figure of Fe30Mn2Mg 1.5Si prepared by the embodiment of the present invention 7.
Fig. 8 is the corrosion electric current density figure of Fe30Mn1.5Zn 2C prepared by the embodiment of the present invention 8.
Fig. 9 is the corrosion electric current density figure of Fe30Mn2Ag 2.5S prepared by the embodiment of the present invention 9.
Embodiment:
Embodiment 1
Powder purity is >=99.9%, mass percent be 66.5% Fe, the Mn of 30%, the Mg of 3% and 0.5% C mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 20:1 and carry out ball milling, rotating speed 400r/min, every ball milling 120min, stop 30min, continue ball milling 20h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 4GPa, heat-insulation pressure keeping 30min synthesising biological degradable quaternary ferrous alloy material at 1200 DEG C.
As seen from Figure 1, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn3Mg0.5C, its phase composite is the oxide compound of austenite structure and manganese, relative to the Fe30Mn of single phase austenite tissue, generate second-phase, accelerate the erosion rate of iron-based body.
Embodiment 2
Powder purity is >=99.9%, mass percent be 66.5% Fe, the Mn of 30%, the Zn of 3% and 0.5 Si mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 25:1 and carry out ball milling, rotating speed 450r/min, every ball milling 120min, stop 30min, continue ball milling 24h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 6GPa, heat-insulation pressure keeping 60min synthesising biological degradable quaternary ferrous alloy material at 1600 DEG C.
As seen from Figure 2, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn3Zn0.5Si, and corrosion electric current density is relative to 3.6 × 10 of Fe30Mn
-4mAcm
-2, brought up to 0.032mAcm
-2.
Embodiment 3
Powder purity is >=99.9%, mass percent be 66.5% Fe, the Mn of 30%, the Ag of 3% and 0.5 S mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 20:1 and carry out ball milling, rotating speed 400r/min, every ball milling 120min, stop 30min, continue ball milling 24h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 5GPa, heat-insulation pressure keeping 60min synthesising biological degradable quaternary ferrous alloy material at 1400 DEG C.
The material that high pressure is prepared as seen from Figure 3 consists of the biodegradable quaternary ferrous alloy material of Fe30Mn3Ag0.5S, and corrosion electric current density is relative to 3.6 × 10 of Fe30Mn
-4mAcm
-2, brought up to 0.035mAcm
-2.
Embodiment 4
Powder purity is >=99.9%, mass percent be 66% Fe, the Mn of 30%, the Zn of 1% and 3% Si mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 25:1 and carry out ball milling, rotating speed 450r/min, every ball milling 120min, stop 30min, continue ball milling 16h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 4GPa, heat-insulation pressure keeping 60min synthesising biological degradable quaternary ferrous alloy material at 1200 DEG C.
As seen from Figure 4, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn1Zn3Si, and corrosion electric current density is relative to 3.6 × 10 of Fe30Mn
-4mAcm
-2, brought up to 0.031mAcm
-2.
Embodiment 5
Powder purity is >=99.9%, mass percent be 66% Fe, the Mn of 30%, the Ag of 1% and 3% C mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 20:1 and carry out ball milling, rotating speed 450r/min, every ball milling 120min, stop 30min, continue ball milling 20h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 6GPa, heat-insulation pressure keeping 30min synthesising biological degradable quaternary ferrous alloy material at 1600 DEG C.
As seen from Figure 5, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn1Ag3C, and corrosion electric current density is relative to 3.6 × 10 of Fe30Mn
-4mAcm
-2, brought up to 0.037mAcm
-2.
Embodiment 6
Powder purity is >=99.9%, mass percent be 66% Fe, the Mn of 30%, the Mg of 1% and 3% S mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 25:1 and carry out ball milling, rotating speed 450r/min, every ball milling 120min, stop 30min, continue ball milling 16h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 4GPa, heat-insulation pressure keeping 30min synthesising biological degradable quaternary ferrous alloy material at 1600 DEG C.
As seen from Figure 6, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn1Mg3S, and optical texture is made up of austenite and second-phase.
Embodiment 7
Powder purity is >=99.9%, mass percent be 66.5% Fe, the Mn of 30%, the Mg of 2% and 1.5% Si mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 23:1 and carry out ball milling, rotating speed 430r/min, every ball milling 120min, stop 30min, continue ball milling 20h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 5GPa, heat-insulation pressure keeping 40min synthesising biological degradable quaternary ferrous alloy material at 1500 DEG C.
As seen from Figure 7, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn2Mg1.5Si, and corrosion electric current density is relative to 3.6 × 10 of Fe30Mn
-4mAcm
-2, brought up to 0.035mAcm
-2.
Embodiment 8
Powder purity is >=99.9%, mass percent be 66.5% Fe, the Mn of 30%, the Zn of 1.5% and 2% C mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 25:1 and carry out ball milling, rotating speed 425r/min, every ball milling 120min, stop 30min, continue ball milling 20h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 5GPa, heat-insulation pressure keeping 50min synthesising biological degradable quaternary ferrous alloy material at 1500 DEG C.
As seen from Figure 8, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn1.5Zn2C, and corrosion electric current density is relative to 3.6 × 10 of Fe30Mn
-4mAcm
-2, brought up to 0.036mAcm
-2.
Embodiment 9
Powder purity is >=99.9%, mass percent be 65.5% Fe, 30%Mn, 2%Ag and 2.5% S mixing, add liquid nitrogen type ball crusher in the ratio of ratio of grinding media to material 22:1 and carry out ball milling, rotating speed 450r/min, every ball milling 120min, stop 30min, continue ball milling 22h, collect the alloy powder pre-molding under 6MPa after ball milling, then six-plane piercer is put at 5.5GPa, heat-insulation pressure keeping 45min synthesising biological degradable quaternary ferrous alloy material at 1450 DEG C.
As seen from Figure 9, the material that high pressure is prepared consists of the biodegradable quaternary ferrous alloy material of Fe30Mn2Ag2.5S, and corrosion electric current density is relative to 3.6 × 10 of Fe30Mn
-4mAcm
-2, brought up to 0.035mAcm
-2.
Claims (3)
1. a biodegradable quaternary ferrous alloy material, is characterized in that: its chemical composition is: Fe-30Mn-nX-kY, n, k are mass percent (wt.%), wherein 1%≤n≤3%, 0.5%≤k≤3%; X is metallic alloying element, comprises the one in Mg, Zn, Ag; Y is non-metallic alloying elements, comprises the one in C, Si, S.
2. biodegradable quaternary ferrous alloy material according to claim 1, is characterized in that: described composition is equal >=99.9% metal of purity or non-metal powder.
3. the preparation method of biodegradable quaternary ferrous alloy material according to claim 1, it is characterized in that: by the metal of mentioned component and non-metal powder mixing, add in liquid nitrogen type ball mill by the ratio of grinding media to material of 20 ~ 25:1 and carry out ball milling, rotating speed is 400 ~ 450r/min, stall 30min, ball milling 16 ~ 24h after the 120min that often operates, by the powder pre-molding obtained, then at 4 ~ 6GPa, heat-insulation pressure keeping 30 ~ 60min at 1200 ~ 1600 DEG C, synthesising biological degradable quaternary ferrous alloy material.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648676A (en) * | 2017-11-08 | 2018-02-02 | 谭思暄 | A kind of degradable iron-based angiocarpy bracket material and preparation method thereof |
| CN108677099A (en) * | 2018-04-17 | 2018-10-19 | 西南大学 | Medical degradable Fe-Mn-Ag alloy materials and preparation and application |
| US10512495B2 (en) | 2017-12-28 | 2019-12-24 | Industrial Technology Research Institute | Method for fabricating medical device and applications thereof |
| CN110952038A (en) * | 2019-11-27 | 2020-04-03 | 苏州森锋医疗器械有限公司 | Biodegradable iron alloy, preparation method and device |
| IT202000003611A1 (en) * | 2020-02-21 | 2021-08-21 | Getters Spa | Bioabsorbable pseudoelastic Fe-Mn-X-Y alloys for medical implants |
| CN113755738A (en) * | 2021-09-10 | 2021-12-07 | 广东粤海华金科技股份有限公司 | Degradable iron-based alloy material and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110318219A1 (en) * | 2010-06-28 | 2011-12-29 | Biotronik Ag | Implant and method for producing the same |
| US20120279881A1 (en) * | 2009-01-08 | 2012-11-08 | Bio Dg, Inc. | Implantable medical devices comprising bio-degradable alloys |
| CN102776435A (en) * | 2011-05-13 | 2012-11-14 | 中国科学院金属研究所 | Degradable Fe-Mn-C ternary iron alloy material and its application |
| US20130243699A1 (en) * | 2011-12-07 | 2013-09-19 | Regents Of The University Of Minnesota | Biodegradable Magnetic Nanoparticles and Related Methods |
| KR101395141B1 (en) * | 2013-05-29 | 2014-05-15 | 대구가톨릭대학교산학협력단 | Manufacturing method of alloy composition for bio-material |
| CN104662191A (en) * | 2012-07-10 | 2015-05-27 | 韦恩堡金属研究产品公司 | Biodegradable alloy wire for medical devices |
-
2015
- 2015-01-28 CN CN201510042513.3A patent/CN104694848B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120279881A1 (en) * | 2009-01-08 | 2012-11-08 | Bio Dg, Inc. | Implantable medical devices comprising bio-degradable alloys |
| US20110318219A1 (en) * | 2010-06-28 | 2011-12-29 | Biotronik Ag | Implant and method for producing the same |
| CN102776435A (en) * | 2011-05-13 | 2012-11-14 | 中国科学院金属研究所 | Degradable Fe-Mn-C ternary iron alloy material and its application |
| US20130243699A1 (en) * | 2011-12-07 | 2013-09-19 | Regents Of The University Of Minnesota | Biodegradable Magnetic Nanoparticles and Related Methods |
| CN104662191A (en) * | 2012-07-10 | 2015-05-27 | 韦恩堡金属研究产品公司 | Biodegradable alloy wire for medical devices |
| KR101395141B1 (en) * | 2013-05-29 | 2014-05-15 | 대구가톨릭대학교산학협력단 | Manufacturing method of alloy composition for bio-material |
Non-Patent Citations (2)
| Title |
|---|
| HENDRA HERMAWAN ET AL.: "Process of prototyping coronary stents from biodegradable Fe-Mn alloys", 《ACTA BIOMATERIALIA》 * |
| 徐文利 等: "新型生物可降解Fe-30Mn-1C合金的性能研究", 《金属学报》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648676A (en) * | 2017-11-08 | 2018-02-02 | 谭思暄 | A kind of degradable iron-based angiocarpy bracket material and preparation method thereof |
| US10512495B2 (en) | 2017-12-28 | 2019-12-24 | Industrial Technology Research Institute | Method for fabricating medical device and applications thereof |
| CN108677099A (en) * | 2018-04-17 | 2018-10-19 | 西南大学 | Medical degradable Fe-Mn-Ag alloy materials and preparation and application |
| CN110952038A (en) * | 2019-11-27 | 2020-04-03 | 苏州森锋医疗器械有限公司 | Biodegradable iron alloy, preparation method and device |
| IT202000003611A1 (en) * | 2020-02-21 | 2021-08-21 | Getters Spa | Bioabsorbable pseudoelastic Fe-Mn-X-Y alloys for medical implants |
| WO2021165333A1 (en) | 2020-02-21 | 2021-08-26 | Saes Getters S.P.A. | Bioresorbable pseudoelastic fe-mn-x-y alloys for medical implants |
| CN113755738A (en) * | 2021-09-10 | 2021-12-07 | 广东粤海华金科技股份有限公司 | Degradable iron-based alloy material and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN104694848B (en) | 2017-03-29 |
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