CN104693217B - Method for preparing cefixime - Google Patents
Method for preparing cefixime Download PDFInfo
- Publication number
- CN104693217B CN104693217B CN201510090398.7A CN201510090398A CN104693217B CN 104693217 B CN104693217 B CN 104693217B CN 201510090398 A CN201510090398 A CN 201510090398A CN 104693217 B CN104693217 B CN 104693217B
- Authority
- CN
- China
- Prior art keywords
- cefixime
- preparation
- solvent
- cephem
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510090398.7A CN104693217B (en) | 2015-02-28 | 2015-02-28 | Method for preparing cefixime |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510090398.7A CN104693217B (en) | 2015-02-28 | 2015-02-28 | Method for preparing cefixime |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104693217A CN104693217A (en) | 2015-06-10 |
CN104693217B true CN104693217B (en) | 2017-01-11 |
Family
ID=53340808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510090398.7A Active CN104693217B (en) | 2015-02-28 | 2015-02-28 | Method for preparing cefixime |
Country Status (1)
Country | Link |
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CN (1) | CN104693217B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111592557A (en) * | 2020-05-09 | 2020-08-28 | 河北合佳医药科技集团股份有限公司 | One-step environment-friendly preparation method of 7-amino-3-vinyl cephalosporanic acid |
CN115326950A (en) * | 2022-07-27 | 2022-11-11 | 广州白云山医药集团股份有限公司白云山制药总厂 | Method for detecting dissolution rate of cefixime |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001023393A1 (en) * | 1999-09-30 | 2001-04-05 | Otsuka Kagaku Kabushiki Kaisha | 3-cephem derivative crystal and method for preparing the same |
WO2005100367A1 (en) * | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | Intermediates useful in the synthesis of 3-(2-substituted vinyl) cephalosporins |
MX2007007476A (en) * | 2004-12-21 | 2007-08-15 | Lupin Ltd | Process for the preparation of cefixime. |
CN101319246B (en) * | 2008-07-17 | 2012-02-15 | 浙江昂利康制药有限公司 | Process for preparing cefixime |
CN103923104B (en) * | 2014-04-25 | 2016-04-13 | 湖北凌晟药业有限公司 | 7-phenylacetylamino-3-vinyl-4-cephemcarboxylic acid is to the preparation method of methoxy benzyl ester |
-
2015
- 2015-02-28 CN CN201510090398.7A patent/CN104693217B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN104693217A (en) | 2015-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent for invention or patent application | ||
CB02 | Change of applicant information |
Address after: Taizhou City, Zhejiang province 318020 gate Huangyan Jiangkou Road Economic Development Zone No. 10 Applicant after: ZHEJIANG HUAFANG PHARMACEUTICAL CO., LTD. Address before: Taizhou City, Zhejiang province 318020 gate Huangyan Jiangkou Road Economic Development Zone No. 10 Applicant before: Shandong Changyi Sifang Pharmaceutical Co., Ltd. |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: SHANDONG CHANGYI SIFANG PHARMACEUTICAL CO., LTD. TO: ZHEJIANG HUAFANG PHARMACEUTICAL CO., LTD. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190116 Address after: 261313 No. 1 Sifang Road, Xiaying Economic Development Zone, Changyi City, Weifang City, Shandong Province Patentee after: Shandong Changyi Sifang Pharmaceutical Chemical Co., Ltd. Address before: 318020 No. 10 Dazhalu Road, Jiangkou Economic Development Zone, Huangyan District, Taizhou City, Zhejiang Province Patentee before: ZHEJIANG HUAFANG PHARMACEUTICAL CO., LTD. |
|
TR01 | Transfer of patent right |