CN104689395A - Experimental facility for dialyzer ultrafiltration rate and clearance rate - Google Patents
Experimental facility for dialyzer ultrafiltration rate and clearance rate Download PDFInfo
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- CN104689395A CN104689395A CN201310659664.4A CN201310659664A CN104689395A CN 104689395 A CN104689395 A CN 104689395A CN 201310659664 A CN201310659664 A CN 201310659664A CN 104689395 A CN104689395 A CN 104689395A
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- Prior art keywords
- dialysis
- dialysis machine
- pipeline
- conduit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/02—Equipment for testing the apparatus
Abstract
The invention relates to an experimental facility for a dialyzer ultrafiltration rate and a clearance rate. The experimental facility comprises a dialysis machine, a blood dialyzer, a water pump, a thermostatic water bath, a dialysis machine peristaltic pump mounted on the dialysis machine, a plurality of dialysis pipelines, and a waste liquor recovery tank arranged below the dialysis pipelines, wherein a water inlet and a dialysate discharge hole are formed in one side of the dialysis machine; a dialysate outlet and a dialysate inlet are formed in the other side of the dialysis machine; the water pump is respectively connected with a water inlet pipe and a water outlet pipe; the water outlet pipe is communicated with the water inlet of the dialysis machine; a pipeline drawn from the thermostatic water bath is twisted on the dialysis machine peristaltic pump on the dialysis machine and communicated with the dialysis pipelines. The experimental facility has the advantages of being capable of accurately determining the transmembrane pressure drop value of the blood dialyzer, so as to ensure the accuracy of the detection result.
Description
Technical field
The invention belongs to dialyser technical field, particularly relate to a kind of dialyser ultrafiltration rate and clearance rate experimental provision.
Background technology
Hemodialysis (Dialysis) is the principle utilizing semipermeable membrane, and the blood of patient and dialysis solution are introduced dialyser simultaneously, both in the both sides of dialyzer in flowing in the other direction, by the solute gradient of film both sides, osmotic gradient and hydraulic pressure gradient.Remove moisture too much in toxin and body to reach, simultaneously required in added body material, and maintain the object of electrolyte and acid-base balance.Clearance rate and ultrafiltrate coefficient are two main performances of dialyser, are also the key indexs evaluating dialyzer quality.
Clearance rate: clearance rate refers to the pure solute through hemodialyzer or transfusion filters.Conventional dialyser transfer area coefficient (KoA) represents.Can simply think KoA be blood and dialysis solution speed large time, the ml/min numerical value of the clearance rate of dialyser maximum possible.Commonly use small-molecule substance as carbamide, creatinine; Medium molecular substance is as vitamin B12, and β2-microglobulin is as the index evaluating clearance of dialyzer.General small throughput dialyser urea clearance rate 180-190ml/min, creatinine clearance rate 160-172ml/min, vitamin B12 clearance rate 60-80ml/min, removes β2-microglobulin hardly.High flux hemodialysis device urea clearance rate 185-192ml/min, creatinine clearance rate 172-180ml/min, vitamin B12 clearance rate 118-135ml/min, after β2-microglobulin dialysis, rate of descent is 40-60%.The clearance rate of dialyser directly reflects dialyzer to Solute removal ability, can know the elimination effect of dialyser to various harmful solute by the clearance rate parameter of dialyser.
Ultrafiltration rate: dialyzer is to the Scavenging activity of water, and its size determines dehydrating amount, and unit is ml/h.mmHg.Ultrafiltrate coefficient reflects the Scavenging activity of dialyzer to water.
Because experimental facilities of the prior art accurately and timely cannot determine the corresponding transmembrane pressure of hemodialyzer, therefore testing result can be affected.
Summary of the invention
The present invention provides a kind of dialyser ultrafiltration rate and the clearance rate experimental provision that accurately and timely can determine the corresponding transmembrane pressure difference of hemodialyzer for solving in known technology the technical problem that exists.
The technical scheme that the present invention takes for the technical problem existed in solution known technology is:
Dialyser ultrafiltration rate and clearance rate experimental provision, comprise dialysis machine, hemodialyzer, water pump, constant temperature water bath, be arranged on the dialysis machine peristaltic pump on dialysis machine, multiple dialysis pipeline and the devil liquor recovery groove be arranged on below dialysis pipeline, described dialysis machine side is provided with water inlet and dialysis solution floss hole, opposite side is provided with dialysis solution outlet and dialysis solution import, described water pump is connected to water inlet pipe and outlet pipe, described outlet pipe is communicated with the water inlet on dialysis machine, to draw in described constant temperature water bath on dialysis machine peristaltic pump that pipeline is wrapped on dialysis machine and with dialysis pipeline connection.
The present invention can also adopt following technical scheme:
Draw pipeline and first pipeline blood inlet of dialysing in described constant temperature water bath to be communicated with, described first Dialysis tubing way outlet is communicated with the blood inlet on hemodialyzer by conduit; Described hemodialyzer blood liquid outlet is communicated with by conduit and second pipeline blood inlet of dialysing, and the second dialysis pipeline blood outlet is communicated with devil liquor recovery groove by conduit; Described hemodialyzer dialysis solution outlet is communicated with the 3rd Dialysis tubing road dialysis solution import by conduit, and the 3rd Dialysis tubing way outlet is by conduit and dialysis machine dialysis solution inlet communication; Described dialysis machine dialysis solution outlet is by conduit and the 4th group of Dialysis tubing road dialysis solution inlet communication, and the 4th Dialysis tubing way outlet is by conduit and hemodialyzer dialysis solution inlet communication.
Described each dialysis pipeline is equipped with Pressure gauge.
Described constant temperature water bath is also equipped with heater.
Described hemodialyzer passes through detachable moveable support installing on dialysis machine.
The advantage that the present invention has and good effect are: because the present invention adopts technique scheme, namely by pipeline, the test fluid in constant temperature water bath is injected hemodialyzer, with enter the solute gradient of dialysis solution by film both sides of hemodialyzer, osmotic gradient and hydraulic pressure gradient to reach the object removing toxin, simultaneously required in added body material, and maintain the object of electrolyte and acid-base balance.After reaction completes, waste liquid is reclaimed.Utilize the Pressure gauge of four pipelines of dialysing to determine, enter the pressure of blood end respectively and go out, enter the pressure of dialysis solution end simultaneously, go out corresponding transmembrane pressure according to formulae discovery, then according to ultrafiltration volume, calculate corresponding ultrafiltration rate.Accurately and timely can determine the corresponding transmembrane pressure of hemodialyzer like this, ensure the accuracy of testing result.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
In figure: 1, constant temperature water bath; 2, heater; 3, water pump; 4, dialysis machine; 5, original dialysis solution import; 6, hemodialyzer; 6-1, blood inlet; 6-2, blood export; 6-3, dialysis solution import; 6-4, dialysis solution export; 7, Pressure gauge; 8, dialysis pipeline; 9, devil liquor recovery groove; 10, dialysis machine peristaltic pump; 11, water inlet pipe; 12, water inlet; 13, dialysis solution outlet; 14, outlet pipe; 15, dialysis solution import; 16, detachable moveable support; 17, dialysis solution floss hole.
Detailed description of the invention
For summary of the invention of the present invention, Characteristic can be understood further, hereby exemplify following examples, and coordinate accompanying drawing to be described in detail as follows:
Refer to Fig. 1, dialyser ultrafiltration rate and clearance rate experimental provision, comprise dialysis machine 4, hemodialyzer 6, water pump 3, constant temperature water bath 1, the dialysis machine peristaltic pump 10 be arranged on dialysis machine, multiple dialysis pipeline 8 and be arranged on the devil liquor recovery groove 9 below dialysis pipeline.Described dialysis machine be provided with original dialysis solution import 5 just above, water inlet 12 and dialysis solution floss hole 17 is provided with just above with adjacent side, be provided with dialysis solution with adjacent opposite side just above and export 13 and dialysis solution import 15, described water pump is connected to water inlet pipe 11 and outlet pipe 14, described outlet pipe is communicated with the water inlet on dialysis machine, to draw in described constant temperature water bath on dialysis machine peristaltic pump 10 that pipeline is wrapped on dialysis machine and with dialysis pipeline connection.Described hemodialyzer 6 is arranged on dialysis machine by detachable moveable support 16.In the present embodiment, draw pipeline and first pipeline blood inlet of dialysing in described constant temperature water bath and be communicated with, described first Dialysis tubing way outlet is communicated with the blood inlet 6-1 on hemodialyzer 6 by conduit; Described hemodialyzer blood outlet 6-2 is communicated with by conduit and second pipeline blood inlet of dialyse, and the second pipeline blood of dialysing exports by conduit connection devil liquor recovery groove 9; Described hemodialyzer dialysis solution outlet 6-4 is communicated with the 3rd Dialysis tubing road dialysis solution import by conduit, and the 3rd Dialysis tubing way outlet is communicated with dialysis machine dialysis solution import 15 by conduit; Described dialysis machine dialysis solution outlet 13 is by conduit and the 4th group of Dialysis tubing road dialysis solution inlet communication, and the 4th Dialysis tubing way outlet is communicated with hemodialyzer dialysis solution import 6-3 by conduit.
In the present embodiment, described each dialysis pipeline is equipped with Pressure gauge 7, and described constant temperature water bath is also equipped with heater 2.
In the test fluid of constant temperature water bath built with constant temperature 37 DEG C, by the conduit on dialysis machine peristaltic pump, the test fluid in constant temperature water bath is drunk up, and by conduit, test fluid is transported to mensuration first and dialyses in pipeline blood inlet, then held by the blood inlet 6-1 that conduit enters into dialyser 6; Dialysis solution outlet on dialysis machine by conduit with measure the 4th Dialysis tubing road dialysis solution inlet communication, the dialysis solution exported from dialysis machine is transported in mensuration the 4th dialysis pipeline, holds delivering into dialyser dialysis solution import 6-3 through conduit.Now, blood (test fluid) in dialyzer inside interacts with the dialysis solution of (dialyzer is outside) in dialyser and realizes dialyse (carrying out blood purification), after having dialysed, blood (waste liquid) after test is transported to mensuration second by conduit and dialyses in pipeline by dialyser blood outlet 6-2 end, is then discharged into devil liquor recovery groove 9 through conduit.Dialyser dialysis solution outlet 6-4 then (will complete blood purification process) by conduit, and dialysis solution is transported in mensuration the 3rd dialysis pipeline, and is delivered to dialysis machine dialysis solution import 15 through conduit, discharges finally by dialysis solution floss hole 17.
Claims (5)
1. a dialyser ultrafiltration rate and clearance rate experimental provision, it is characterized in that: comprise dialysis machine (4), hemodialyzer (6), water pump (3), constant temperature water bath (1), be arranged on the dialysis machine peristaltic pump (10) on dialysis machine, multiple dialysis pipeline (8) and the devil liquor recovery groove (9) be arranged on below dialysis pipeline, described dialysis machine side is provided with water inlet (12) and dialysis solution floss hole (17), opposite side is provided with dialysis solution outlet (13) and dialysis solution import (15), described water pump is connected to water inlet pipe (11) and outlet pipe (14), described outlet pipe is communicated with the water inlet (12) on dialysis machine, draw in described constant temperature water bath pipeline be wrapped in dialysis machine peristaltic pump (10) on dialysis machine upper and with dialysis pipeline connection.
2. dialyser ultrafiltration rate according to claim 1 and clearance rate experimental provision, it is characterized in that: draw pipeline and first pipeline blood inlet of dialysing in described constant temperature water bath and be communicated with, described first Dialysis tubing way outlet is communicated with the blood inlet on hemodialyzer by conduit; Described hemodialyzer blood liquid outlet is communicated with by conduit and second pipeline blood inlet of dialysing, and the second dialysis pipeline blood outlet is communicated with devil liquor recovery groove (9) by conduit; Described hemodialyzer dialysis solution outlet is communicated with the 3rd Dialysis tubing road dialysis solution import by conduit, and the 3rd Dialysis tubing way outlet is communicated with dialysis machine dialysis solution import (15) by conduit; Described dialysis machine dialysis solution outlet (13) is by conduit and the 4th group of Dialysis tubing road dialysis solution inlet communication, and the 4th Dialysis tubing way outlet is by conduit and hemodialyzer dialysis solution inlet communication.
3. dialyser ultrafiltration rate according to claim 2 and clearance rate experimental provision, is characterized in that: described each dialysis pipeline is equipped with Pressure gauge.
4. dialyser ultrafiltration rate according to claim 1 and clearance rate experimental provision, is characterized in that: described constant temperature water bath is also equipped with heater (2).
5. dialyser ultrafiltration rate according to claim 1 and clearance rate experimental provision, is characterized in that: described hemodialyzer passes through detachable moveable support installing on dialysis machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310659664.4A CN104689395A (en) | 2013-12-05 | 2013-12-05 | Experimental facility for dialyzer ultrafiltration rate and clearance rate |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310659664.4A CN104689395A (en) | 2013-12-05 | 2013-12-05 | Experimental facility for dialyzer ultrafiltration rate and clearance rate |
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| CN104689395A true CN104689395A (en) | 2015-06-10 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105363085A (en) * | 2015-12-10 | 2016-03-02 | 威海威高血液净化制品有限公司 | Blood purification device |
| CN106124139A (en) * | 2016-08-17 | 2016-11-16 | 上海佩尼医疗科技发展有限公司 | A kind of method of quick detection dialyser seepage |
| CN107875467A (en) * | 2017-12-29 | 2018-04-06 | 威海威高血液净化制品有限公司 | A kind of Multifunction blood dialyzer performance testing device and application method |
| CN108379678A (en) * | 2018-01-31 | 2018-08-10 | 东南大学 | A kind of hemo system dialysis-effect detecting system and its control method |
| CN111529788A (en) * | 2020-05-07 | 2020-08-14 | 深圳市中医院 | Peritoneal dialysis-based ultrafiltration volume prediction method |
| CN112945833A (en) * | 2021-03-04 | 2021-06-11 | 贝恩医疗设备(广州)有限公司 | Measure cerini dialyser cerini hollow fiber membrane water flux tester |
-
2013
- 2013-12-05 CN CN201310659664.4A patent/CN104689395A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105363085A (en) * | 2015-12-10 | 2016-03-02 | 威海威高血液净化制品有限公司 | Blood purification device |
| CN106124139A (en) * | 2016-08-17 | 2016-11-16 | 上海佩尼医疗科技发展有限公司 | A kind of method of quick detection dialyser seepage |
| CN106124139B (en) * | 2016-08-17 | 2019-01-29 | 上海佩尼医疗科技发展有限公司 | A kind of method of quick detection dialyzer leakage |
| CN107875467A (en) * | 2017-12-29 | 2018-04-06 | 威海威高血液净化制品有限公司 | A kind of Multifunction blood dialyzer performance testing device and application method |
| CN108379678A (en) * | 2018-01-31 | 2018-08-10 | 东南大学 | A kind of hemo system dialysis-effect detecting system and its control method |
| CN108379678B (en) * | 2018-01-31 | 2020-11-20 | 东南大学 | Hemodialysis machine dialysis effect detection system and control method thereof |
| CN111529788A (en) * | 2020-05-07 | 2020-08-14 | 深圳市中医院 | Peritoneal dialysis-based ultrafiltration volume prediction method |
| CN111529788B (en) * | 2020-05-07 | 2023-01-24 | 深圳市中医院 | Peritoneal dialysis-based ultrafiltration volume prediction method |
| CN112945833A (en) * | 2021-03-04 | 2021-06-11 | 贝恩医疗设备(广州)有限公司 | Measure cerini dialyser cerini hollow fiber membrane water flux tester |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150610 |