CN104688767B - Purposes of the An Taole in preparing for anti-additive medicament - Google Patents
Purposes of the An Taole in preparing for anti-additive medicament Download PDFInfo
- Publication number
- CN104688767B CN104688767B CN201510115830.3A CN201510115830A CN104688767B CN 104688767 B CN104688767 B CN 104688767B CN 201510115830 A CN201510115830 A CN 201510115830A CN 104688767 B CN104688767 B CN 104688767B
- Authority
- CN
- China
- Prior art keywords
- peach
- purposes
- preparing
- peace
- pleasure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 80
- 239000000654 additive Substances 0.000 title claims abstract description 35
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 54
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 54
- 229940079593 drug Drugs 0.000 claims abstract description 40
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims description 8
- 229960002069 diamorphine Drugs 0.000 claims description 8
- 206010002091 Anaesthesia Diseases 0.000 claims description 7
- 230000037005 anaesthesia Effects 0.000 claims description 7
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 6
- 230000003340 mental effect Effects 0.000 claims description 6
- 239000008896 Opium Substances 0.000 claims description 4
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 229940127240 opiate Drugs 0.000 claims description 4
- 229960001027 opium Drugs 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- ZPPBASOODYCKDP-YZZSNFJZSA-N (4r,4ar,7s,7ar,12bs)-9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;hydrochloride Chemical class Cl.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OCC ZPPBASOODYCKDP-YZZSNFJZSA-N 0.000 claims description 3
- XUDUTRMKKYUAKI-UHFFFAOYSA-N 3-[1-(1-phenylethyl)piperidin-4-yl]-1h-benzimidazol-2-one Chemical compound C1CC(N2C(NC3=CC=CC=C32)=O)CCN1C(C)C1=CC=CC=C1 XUDUTRMKKYUAKI-UHFFFAOYSA-N 0.000 claims description 3
- 244000025254 Cannabis sativa Species 0.000 claims description 3
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims description 3
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000002269 analeptic agent Substances 0.000 claims description 3
- 239000002249 anxiolytic agent Substances 0.000 claims description 3
- 230000000949 anxiolytic effect Effects 0.000 claims description 3
- 235000009120 camo Nutrition 0.000 claims description 3
- 235000005607 chanvre indien Nutrition 0.000 claims description 3
- 229960003920 cocaine Drugs 0.000 claims description 3
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical class C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 3
- 239000011487 hemp Substances 0.000 claims description 3
- 239000005554 hypnotics and sedatives Substances 0.000 claims description 3
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims description 3
- 229960001252 methamphetamine Drugs 0.000 claims description 3
- 230000001337 psychedelic effect Effects 0.000 claims description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 229960002715 nicotine Drugs 0.000 claims description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 abstract description 27
- 238000001784 detoxification Methods 0.000 abstract description 15
- 230000007812 deficiency Effects 0.000 abstract description 6
- 230000003533 narcotic effect Effects 0.000 abstract description 6
- 102000009025 Endorphins Human genes 0.000 abstract description 5
- 108010049140 Endorphins Proteins 0.000 abstract description 5
- 230000036592 analgesia Effects 0.000 abstract description 5
- 230000036407 pain Effects 0.000 abstract description 5
- 102000001490 Opioid Peptides Human genes 0.000 abstract description 4
- 108010093625 Opioid Peptides Proteins 0.000 abstract description 4
- 230000001154 acute effect Effects 0.000 abstract description 4
- 239000003399 opiate peptide Substances 0.000 abstract description 4
- 239000013589 supplement Substances 0.000 abstract description 4
- 206010042434 Sudden death Diseases 0.000 abstract description 3
- 230000009692 acute damage Effects 0.000 abstract description 3
- 210000003169 central nervous system Anatomy 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 3
- 239000004081 narcotic agent Substances 0.000 abstract description 3
- 208000019901 Anxiety disease Diseases 0.000 abstract description 2
- 230000036506 anxiety Effects 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 15
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 239000001272 nitrous oxide Substances 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 206010013654 Drug abuse Diseases 0.000 description 3
- 229910003798 SPO2 Inorganic materials 0.000 description 3
- 101100478210 Schizosaccharomyces pombe (strain 972 / ATCC 24843) spo2 gene Proteins 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 238000005339 levitation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 208000011117 substance-related disease Diseases 0.000 description 3
- 230000035488 systolic blood pressure Effects 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
- 206010000125 Abnormal dreams Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010001526 Air embolism Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101800005209 Deltorphin Proteins 0.000 description 1
- BHSURCCZOBVHJJ-NWOHMYAQSA-N Deltorphin A Chemical compound C([C@H](N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(N)=O)C1=CC=C(O)C=C1 BHSURCCZOBVHJJ-NWOHMYAQSA-N 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000003698 Heroin Dependence Diseases 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 208000027382 Mental deterioration Diseases 0.000 description 1
- 206010027374 Mental impairment Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 229960001797 methadone Drugs 0.000 description 1
- 208000022949 middle ear disease Diseases 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000009125 negative feedback regulation Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000024335 physical disease Diseases 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 201000003144 pneumothorax Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Abstract
The present invention, which is provided, pacifies the purposes that peach pleasure is used in anti-additive medicament in preparation, that is, a kind of new application that peace peach finds pleasure in, and is used for narcotics abstinence；An Taole is used as a kind of medicine being widely used in the analgesia of the early stage of acute injury and required analgesia time shorter operation and other invasive medical care precesses, with safety, effectively, it is easy, it is economical, it is noninvasive, the advantage of narcotic-based painkillers can be substituted, central nervous system can be activated, promote the release of endogenous opiatepeptide, body is caused to discharge endorphin deficiency because of long-term consume illegal drugs so as to supplement, old medicine is newly used, the scope of application is widened as anti-additive medicament, An Taole can also be alleviated painful caused by withrawal symptom simultaneously, releive anxiety, reduce acute sudden death etc. caused by serious withrawal symptom, so that addict received treatment is during whole detoxification treatment, no pain, keep clear-headed, loosen, comfortably, partner treatment.
Description
Technical field：
The present invention relates to anti-additive medicament, purposes of the peace peach pleasure in preparing for anti-additive medicament is more particularly said.
Background technology：
Take drugs and not only break up the normal physiological function and immunologic function of people, drug addict is caught a variety of diseases, and make one
Mental deterioration, entanglement, dignity of forfeiting personal dignity, addict is engaged in muscle power and the ability of intellectual work gradually weakens, or even most
After completely lose, as be unprofitable to society disabled person, even more serious then causes death, in terms of the species of drug abuse, take drugs
Crowd is still to abuse based on the opium drugs such as heroin.
It is all severe problem to quit drug abuse for any one current country, and effectively control withrawal symptom is the pass of detoxification treatment
Key, domestic drug rehabilitation is basic based on forced quarantine at present, and compulsory rehabilitation center's generally existing task weight, funds are nervous, manpower and materials
The many difficulties such as deficiency, treatment and nursing and supervisor's task are very heavy.Methadone has used half as traditional anti-additive medicament
Individual century, have the advantages that control withrawal symptom completely, it is long action time, safety, easy to use, but its main deficiency is for oneself
Body exists additive, and withdrawal is difficult, and withrawal symptom easily repeatedly, influences detoxification efficiency.Therefore, exploring drug rehabilitation good effect, safety can
Lean on, do not cause new drug habit, and the detoxification scheme of moderate, easy and safe to operate, curative effect certainly is imperative.
Peace peach pleasure of the present invention is then a kind of early stage analgesia and required analgesia for being widely used in acute injury
Time it is shorter operation and other invasive medical care precesses in medicine, by 50% nitrous oxide (N2) and 50% oxygen (O O2) composition
Mixed gas, have the advantages that safely, effectively, it is easy, economical, noninvasive, can substitute narcotic-based painkillers, work within 20 seconds.This
Inventor has found that the peace happy gas of peach can activate central nervous system, promotes the release of endogenous opiatepeptide, so as to supplement because long
Phase consumes illegal drugs and causes body to discharge endorphin deficiency, and stops after the suction peace happy gas of peach, and maincenter is within a certain period of time
It is still sustainable to produce a certain amount of endogenous opiatepeptide, so An Taole is listed as a by examining, clinical big
Measure the safe drugs that use, can old medicine newly use, widen the scope of application as anti-additive medicament, supplement is because of in long-term drug abuse body
The deficiency of deltorphin delta system internal endorphin caused by being suppressed, while can also alleviate pain caused by withrawal symptom, releive Jiao
Consider mood, reduce acute sudden death etc. caused by serious withrawal symptom so that addict received treatment is painless during whole detoxification treatment
Hardship, keeps clear-headed, loosens, comfortably, partner treatment.
The content of the invention：
The present invention provides a kind of new opplication of peace peach pleasure, and peace peach pleasure is applied into drug rehabilitation, opium drug is especially given up
Application in terms of heroin, the peace peach pleasure is by 50% nitrous oxide (N2) and 50% oxygen (O O2) composition mixed gas.
Concrete technical scheme is：
Purposes of the An Taole in preparing for anti-additive medicament, An Taole is used to give up anesthesia class, mental or alcohol
The application of class drugs.
Preferably, the anesthesia class drugs are opiates, m orphine, cocaines, ethylmorphine hydrochloride class, codeine class
Or synthesis arcotic class.
Preferably, the mental drugs are hypnotic sedative agent, anxiolytic, central stimulant or psychedelic.
Optimal, it is hemp, cocaine, methamphetamine, nicotine, heroin that the peace peach, which finds pleasure in for narcotics abstinence,.
Optimal, it is heroin that the peace peach, which finds pleasure in for narcotics abstinence,.
The happy 6-15 liters of peach are pacified in purposes of the An Taole in preparing for anti-additive medicament, every time suction, and male preferably inhales every time
Enter to pacify the happy 11-12 liters of peach, preferably the happy 9-10 liters of peach are pacified in suction to women every time；
Purposes of the An Taole in preparing for anti-additive medicament, suction peace peach is happy 2-3 times daily, preferably 3 times a day.
Purposes of the An Taole in preparing for anti-additive medicament, peace peach pleasure is administered alone；
Purposes of the An Taole in preparing for anti-additive medicament, peace peach pleasure is sub-packed in 2-40 and rises standby in steel cylinder.
As shown from the above technical solution, the invention provides a kind of An Taole new purposes application, that is, pacify peach pleasure and be used as
Drug rehabilitation, purposes of the An Taole in preparing for anti-additive medicament.
An Taole is listed for many years as one kind by examination ＆ approval, and the early stage for being widely used in acute injury eases pain and required
Analgesia time it is shorter operation and other invasive medical care precesses in medicine, with safely, effectively, it is easy, economical, noninvasive, make
The advantages of for anodyne, also there is significant effect for drug rehabilitation, on the one hand by activating central nervous system, promote endogenous
Property opioid peptides release, so as to supplement because long-term consume illegal drugs caused by body endorphin system is suppressed endorphin in vivo
Deficiency, on the other hand can also alleviate caused by withrawal symptom painful, anxiety of releiving, reduce caused by serious withrawal symptom
Acute sudden death etc. so that addict received treatment is during whole detoxification treatment, no pain, keeps clear-headed, loosens, comfortably, cooperation is controlled
Treat, finally eliminate to dependence of the drug addict for drugs.
Patient clinically has levitation or terrified sensation after An Taole suctions, just serves analgesic
Effect.In addict received treatment in use, still with levitation or it is terrified be felt as action confining method, having these
It can just stop sucking gas during sensation, complete treatment once.
Embodiment：
Purposes of the An Taole in preparing for anti-additive medicament, An Taole is used to give up anesthesia class, mental or alcohol
The application of class drugs；The anesthesia class drugs be opiates, m orphine, cocaines, ethylmorphine hydrochloride class, codeine class or
Synthesize arcotic class；The mental drugs are hypnotic sedative agent, anxiolytic, central stimulant or psychedelic.
Purposes of the An Taole in preparing for anti-additive medicament, An Taole is used to give up hemp, cocaine, methamphetamine, Ni Gu
Fourth, heroin；Especially heroin to give up effect best.
The happy 6-15 liters of peach are pacified in purposes of the An Taole in preparing for anti-additive medicament, every time suction, and male preferably inhales every time
Enter to pacify the happy 11-12 liters of peach, preferably the happy 9-10 liters of peach are pacified in suction to women every time；
Purposes of the An Taole in preparing for anti-additive medicament, suction peace peach is happy 2-3 times daily, preferably 3 times a day.
Purposes of the An Taole in preparing for anti-additive medicament, peace peach pleasure is administered alone；
Purposes of the An Taole in preparing for anti-additive medicament, peace peach pleasure is sub-packed in 2-40 and rises standby in steel cylinder.
Embodiment：
The pharmacodynamics clinical test of present invention peace peach pleasure；
The present invention is in Department of Justice of area of Ningxia Hui Autonomous Region, public security bureau subordinate Yinchuan forced quarantine narcotic house, Yinchuan woman
Forced quarantine narcotic house, Yinchuan public security narcotic house under the assistance of unit such as Wuzhong public security narcotic house, observes An Taole to Hai Luo
Detoxification curative effect and adverse reaction because of habituation withrawal symptom.The happy gas of peace peach used is by 50% nitrous oxide (N2O) and
50% oxygen (O2) composition mixed gas, peace peach pleasure prepares using the following method：In the temperature more than subzero 6 DEG C
Under, gaseous oxygen is dissolved in the nitrous oxide of liquid, both gases utilize " the slope print court of a feudal ruler " effect to remain under high pressure
Gaseous state is kept, O is formed after gasification2/N2O mixed gas, above-mentioned mixed gas can be placed in standby in the steel cylinder of 2-40 liters
With.
First, research object
Selection meets the 120 Patients with Heroin Dependence of DSM-IV opioid addict diagnostic criteria, and all cases are accorded with
Diagnostic criteria of the DSM-IV about " substance depilatory " is closed, the Drug Addicts of CCMD-3 diagnostic criteria are also complied with, urine is surveyed morphine and determined
Property experiment it is positive；Severe physical disease and other severe mental disturbances person are excluded, intestinal obstruction is excluded, air embolism, pneumothorax, insane
The respiratory disease such as epilepsy, obstructive respiration patient and acute upper respiratory infection, exclude nasosinusitis, middle ear diseases, eardrum and move
The ear nose larynx organ patients such as plant, exclusion previously have abuse analgesic history patient and pregnant woman.
2nd, research method
Clinical trial registration number of the present invention：ChiCTR-TRC-14005015, ethics official written reply number：Peaceful medical university ethics 2013-
174。
From ethics angle, it is contemplated that the pain of patient, the seminar being made up of statistics expert proposes test group
With control group according to 3：120 subjects are randomly divided into the people for the treatment of group 90 and the people of control group 30 by 1 packet at random, carry out by a definite date 7
It medication and observation, treatment group is using the peace happy gas detoxification of peach, and control group is using conventional forced quarantine method of abstention detoxification, control
Observe two groups and give up situation.
Using the method for single blind randomized control study, i.e.,：It will at random be grouped, controlling after subject number by random number code
First 10 minutes are treated by fixed research group membership Kaifeng ancestor's volume bag, intervention, patient and data collector are implemented according to random number equal
Intervention means are not known.
Control group is using conventional forced quarantine method of abstention (dry to guard against), i.e., in the case where not intervening to any drug rehabilitation, in nothing
In the presence of exogenous opioid, by the principle of drug addict itself Opioid System negative-feedback regu- lation, pass through 7-20 days
Clear-cutting forestland process reach gradually detoxification.
Treatment group is using the peace happy gas detoxification of peach：Get ready and use thing, addict received treatment is taken to therapeutic room, takes clinostatism, by this
Fixed research group membership is instructed test group subject；Every observation index before treatment is gathered by designated recorder person；
Air valve is opened by researcher, is that addict received treatment fixes mask, deeply breathes and suck the gas, inquires that it has levitation or scalp hair
The sensation of fiber crops can stop pacifying the suction of the happy gas of peach；The indices of patient after record treatment, doctor, association police and drug abstainer pair
The satisfaction of the poison-removing method.
3rd, observation index：
MAIN OUTCOME MEASURES：Use clinical refraining opium type material Syndrome Scale (The Clinical Opiate
Withdrawal Scale, COWS) withrawal symptom scoring is carried out, scale sets 11 contents, scored according to degree altogether, total subtotaling
5-12 points are slight, and 13-24 points are moderate, and 25-36 points are middle severe, are serious withrawal symptom more than 36 points.Withrawal symptom
Scoring<5 points are thought withrawal symptom complete incidence graph, you can terminate treatment.
Secondary observation index：HR, BP, SPO2 and adverse reaction (nauseous, drowsiness, noise sense, dizziness, bad dream, memory loss, mistake
Degree ventilation) influence.
4th, result of the test
Three after the treatment group's treatment found pleasure in using peace peach, four, five, six days detoxification numbers be respectively 25,28,26,11 people, treatment
Afterwards in addition to insomnia, other withrawal symptoms disappearance person works in which can descend, and stops treatment.
The control group detoxification personnel's various symptoms given up taking addictive drugs by force persistently are broken out, until the 7th -day-old of partial symptoms are still suffered from, nothing
Method is fallen asleep, and symptom just gradually mitigates after 7-10 days.
Table 1：The withrawal symptom scoring situation for the treatment of group and control group
Scored according to degree, total subtotaling 5-12 points are slight, and 13-24 points are moderate, and 25-36 points are middle severe, are more than
36 points are serious withrawal symptom.Withrawal symptom scores<5 points are thought withrawal symptom complete incidence graph, you can terminate treatment.From table
As can be seen that after suction peace peach finds pleasure in treatment, the equal complete incidence graph of withrawal symptom of drug abstainer, peace peach pleasure treatment is front and rear in lattice 1,
Effect significantly, and by continuous several days treatment, before suction peace peach pleasure, also alleviated by the withrawal symptom of drug abstainer,
It is in be decreased obviously trend that whole withrawal symptom degree, which is, and by the treatment of seven days, the withrawal symptom of drug abstainer was from seriously to
Complete incidence graph, only needs to oxygen comfort treatment for last two days.The withrawal symptom of control group is to moderate, not having still seriously
Give up, also want continual cure.Conventional forced quarantine method of abstention detoxification is considerably better than by the effect for pacifying peach pleasure treatment.
Table 2：Treatment group and control group drug abstainer mode of onset
It is lasting breaking-out from Table 2, it can be seen that control group does not have paresthesia epilepsy interval over the course for the treatment of, and 7 days
The course for the treatment of in, except insomnia is outer, to violate addiction number be always 30 people, that is, does not have effect.Treatment group is during the treatment of seven days, disease
Shape breaking-out interval time is increasingly longer, and number of persistently breaking out is fewer and fewer until nobody persistently breaks out, while before treatment
Phase, addict received treatment's criminal's addiction number in addition to insomnia is relatively more, but number falls below a people when later stage, and effect is notable.
The influence of the vital sign of each in therapeutic process：Heart rate, systolic pressure before control group, treatment patient's treatment, diastole
Pressure and SpO2 aspects not statistically significant (P values are all higher than 0.05).Heart rate, systolic pressure, diastolic pressure after treatment group patient treatment
Compare with SPO2, difference is statistically significant (P values are respectively less than 0.001).Diastolic blood pressure values are close to (P after two groups of patients treatment>
0.05), the statistically significant (P of comparing difference between heart rate, systolic pressure and SPO2 groups<0.05 or P<0.01).
Table 3：Treatment group and the oxygen saturation situation of control group
Conclusion：The peace happy gas of peach has effects rapid-action, noninvasive, without additive, Small side effects, significantly shortening detoxification time
Really；It is the medicine for having been approved by listing to pacify peach pleasure simultaneously, safe and convenient to use by clinical test, is bought while market is convenient；
Doctor's advice under doctor, drug abstainer self-administration under the simple guidance of medical personnel manages safe ready, is not required to specialty anesthesia doctor
Teacher, the features such as drug abstainer can participate in treatment under waking state.So An Taole has remarkable result, Ke Yituo for drug rehabilitation
Purposes is opened up, peace peach pleasure is regard as anti-additive medicament application.
Claims (12)
1. pacify purposes of the peach pleasure in preparing for anti-additive medicament, it is characterised in that：An Taole prepare be used for give up anesthesia class,
Purposes in mental or alcohol type drugs medicine.
2. purposes of the peace peach pleasure according to claim 1 in preparing for anti-additive medicament, it is characterised in that：The anesthesia
Class drugs are opiates, cocaines or synthesis arcotic class.
3. purposes of the peace peach pleasure according to claim 2 in preparing for anti-additive medicament, it is characterised in that：The opium
Class is one kind in m orphine, ethylmorphine hydrochloride class, codeine class.
4. purposes of the peace peach pleasure according to claim 1 in preparing for anti-additive medicament, it is characterised in that；The spirit
Class drugs are hypnotic sedative agent, anxiolytic, central stimulant or psychedelic.
5. purposes of the peace peach pleasure according to claim 1 in preparing for anti-additive medicament, it is characterised in that：The drugs
For hemp, cocaine, methamphetamine, nicotine, heroin.
6. purposes of the peace peach pleasure according to claim 1 in preparing for anti-additive medicament, it is characterised in that：The drugs
For heroin.
7. any one purposes of peace peach pleasure in preparing for anti-additive medicament according to claim 1-6, its feature exists
In：The happy 6-15 liters of peach are pacified in suction every time.
8. purposes of the peace peach pleasure according to claim 7 in preparing for anti-additive medicament, it is characterised in that：Male is preferred
The happy 11-12 liters of peach are pacified in suction every time, and preferably the happy 9-10 liters of peach are pacified in suction to women every time.
9. purposes of the peace peach pleasure according to claim 8 in preparing for anti-additive medicament, it is characterised in that：Suction daily
Pacify peach happy 2-3 times,
10. purposes of the peace peach pleasure according to claim 9 in preparing for anti-additive medicament, it is characterised in that：Inhale daily
Enter to pacify peach to find pleasure in 3 times.
11. purposes of the An Taole in preparing for anti-additive medicament according to any one in claim 9~10, it is special
Levy and be：An Taole is administered alone.
12. purposes of the peace peach pleasure according to claim 11 in preparing for anti-additive medicament, it is characterised in that：An Taole
It is sub-packed in 2-40 and rises standby in steel cylinder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510115830.3A CN104688767B (en) | 2015-03-17 | 2015-03-17 | Purposes of the An Taole in preparing for anti-additive medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510115830.3A CN104688767B (en) | 2015-03-17 | 2015-03-17 | Purposes of the An Taole in preparing for anti-additive medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104688767A CN104688767A (en) | 2015-06-10 |
| CN104688767B true CN104688767B (en) | 2017-10-24 |
Family
ID=53336593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510115830.3A Expired - Fee Related CN104688767B (en) | 2015-03-17 | 2015-03-17 | Purposes of the An Taole in preparing for anti-additive medicament |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104688767B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193838A (en) * | 2015-09-15 | 2015-12-30 | 宁夏恩多芬科技有限公司 | New technology of nitrous oxide quick-acting drug treatment |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1829522A (en) * | 2003-07-30 | 2006-09-06 | 液体空气卫生(国际)公司 | Inhalable gaseous medicine based on xenon and nitrous oxide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127165B (en) * | 2012-02-23 | 2015-03-11 | 李玉香 | Inhalation analgesic and manufacture method and application thereof |
| CN104337830A (en) * | 2013-11-12 | 2015-02-11 | 余建强 | Addiction-free inhalation rehabilitation agent |
-
2015
- 2015-03-17 CN CN201510115830.3A patent/CN104688767B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1829522A (en) * | 2003-07-30 | 2006-09-06 | 液体空气卫生(国际)公司 | Inhalable gaseous medicine based on xenon and nitrous oxide |
Non-Patent Citations (2)
| Title |
|---|
| MARK A.GILLMAN et al.Pharmacology of Psychotropic Analgesic Nitrous Oxide as a Multipotent Opioid Agonist.《International Journal of Ncuroscience》.1994,第76卷5-12. * |
| MARK A.GILLMAN et al.PSYCHOTROPIC ANALGESIC NITUOUS OXIDE FOR ACUTE COCAINE WITHDRAWAL IN MAN.《Intern.J.Neuroscience》.2006,第116卷847-857. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104688767A (en) | 2015-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104688767B (en) | Purposes of the An Taole in preparing for anti-additive medicament | |
| WRIGHT et al. | Lobeline sulfate: Its pharmacology and use in the treatment of the tobacco habit | |
| CN104337830A (en) | Addiction-free inhalation rehabilitation agent | |
| CN103127165B (en) | Inhalation analgesic and manufacture method and application thereof | |
| CN105193838A (en) | New technology of nitrous oxide quick-acting drug treatment | |
| Zingade et al. | Medical Emergencies in Dentistry: A Review | |
| Pirec et al. | Cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers. | |
| Stanley | Morphinism | |
| Meyer et al. | Pharmacology, Clinical and Experimental: A Groundwork of Medical Treatment, Being a Text-book for Students and Physicians | |
| Featherstone | Basal anaesthetics and allied substances: their use and misuse | |
| ZHANG et al. | Clinical observation on 78 cases of insomnia from Uganda treated by scalp acupuncture | |
| CN105031456A (en) | Traditional Chinese medicine prescription for relieving cough | |
| Arnott | The Question Considered:-Is it Justifiable to Administer Chloroform in Surgical Operations, After Its Having Proved Suddenly Fatal in Upwards of Fifty Cases, when Pain Can be Safely Prevented, Without Loss of Consciousness, by Momentary Benumbing Cold?. | |
| Slot et al. | PHARMACOLOGY AND THERAPEUTICS OF SODIUM EVIPAN | |
| CN116807675A (en) | Method for general anesthesia of pandas | |
| Wang | Study on the Clinical Effect of Dezocine and Remifentanil Combined with Propofol in Anesthesia for Painless Abortion | |
| Blundell | Painless Tooth-Extraction Without Chloroform. With Observations on Local Anæthesia by Congelation in General Surgery | |
| CN109966255A (en) | It is a kind of for adopting noninvasive analgesic and its application method in ovum art | |
| Tsapikova et al. | Progress in Anaesthesiology | |
| White | Anaesthetics | |
| Williams | PROGRESS OF MEDICAL SCIENCE. | |
| Hutchison et al. | An index of treatment by various writers | |
| Brown | EXPERIENCES WITH SODIUM AMYTAL AS A GENERAL ANÆSTHETIC | |
| Luckhardt | Historical High Lights and Shadows in the Discovery of General Anesthesia. | |
| Ferneini | 2 Inhalation Anesthetic Agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180119 Address after: Shanghai Lu Gong Xiang, Jinfeng District, Yinchuan City, silver 750002 the Ningxia Hui Autonomous Region Kyrgyzstan gentle Park 11-2-501 Patentee after: Ma Hong Address before: 750001 the Ningxia Hui Autonomous Region Yinchuan city Xingqing District in the East Nanxun bodied City block C room 505 Patentee before: NINGBO ENDORPHELLON TECHNOLOGY CO.,LTD. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171024 |