CN104667438A - Cartilage rehabilitation stimulation device on basis of low-intensity pulse ultrasonic wave and control method of cartilage rehabilitation stimulation device - Google Patents
Cartilage rehabilitation stimulation device on basis of low-intensity pulse ultrasonic wave and control method of cartilage rehabilitation stimulation device Download PDFInfo
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Abstract
The invention provides a cartilage rehabilitation stimulation device on the basis of a low-intensity pulse ultrasonic wave and a control method of the cartilage rehabilitation stimulation device. The device comprises a processor module, a signal generator module, a PWM (Pulse Width Modulation) analog switch module, a controllable gain amplification module, a power amplifier, an inductance capacitance matching circuit and an ultrasonic transducer. The control method comprises the following steps: the signal generator module generates a required sine wave signal with the frequency of 1.5 MHz; a processor controls the PWM analog switch module, so that an output signal is a pulse sine wave signal with the repetition frequency of 1 KHz, the pulse width of 200 [mu]s and the signal frequency of 1.5MHz; after the output signal is transferred to the ultrasonic transducer by the inductance capacitance matching circuit, the low-intensity pulse ultrasonic wave with the intensity of 30mW/cm<2> is output. The cartilage rehabilitation stimulation device on the basis of the low-intensity pulse ultrasonic wave and the control method of the cartilage rehabilitation stimulation device are adopted to make a stimulation plan for cartilage injury patients with different ages and different disease causes, namely, a stimulation position and stimulation time are determined, so as to help the cartilage injury patients to rehabilitate or achieve the purpose of delaying senile knee joint cartilage degeneration.
Description
Technical field
The invention belongs to biological electronic technology and biomedical engineering field, specifically a kind of cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound and control method thereof.
Background technology
Along with developing rapidly of science and technology, the application of electronic technology relevant with medical level is more and more extensive, and medical electronics also gets more and more in the application of family and hospital.Annual have the fracture of millions of example and cartilage injury's case to occur, to being used for the treatment of or promoting that the demand of the Medical Instruments that fracture and cartilage injury repair is increasing, simultaneously also more and more higher to the requirement of its stability and power consumption.Therefore, develop special ultrasonic cartilage rehabilitation electronic equipment and there is very important using value.
Cartilage to play weight-bearing load in organization of human body, reduce and close the important effect such as internode skeleton friction.
Summary of the invention
The object of the present invention is to provide a kind of cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound and control method thereof.
Technical scheme of the present invention is:
Based on a cartilage rehabilitation stimulating apparatus for low intensity pulsed ultrasound, comprising: processor module, signal generator module, PWM analog switch module, controllable gain amplification module, power amplifier, inductance capacitance match circuit and ultrasonic transducer;
The control input end of the control output end difference connection signal generator module of processor module, the control input end of controllable gain amplification module and the control input end of PWM analog switch module, the outfan of signal generator module connects the input of controllable gain amplification module, the outfan of controllable gain amplification module connects the input of power amplifier, the outfan of power amplifier connects the input of PWM analog switch module, the outfan of PWM analog switch module connects the input of inductance capacitance match circuit, the outfan of inductance capacitance match circuit connects the input of ultrasonic transducer, the low intensity pulsed ultrasound that ultrasonic transducer exports acts on cartilage.
Described signal generator module comprises sinusoidal signal generator and prime wave filter;
Processor module controls the sinusoidal signal that sinusoidal signal generator produces 1.5MHz, processor module connects sinusoidal signal generator and PWM analog switch module by serial line interface, the outfan of sinusoidal signal generator connects the input of prime wave filter, and the outfan of prime wave filter connects the input of controllable gain amplification module.
Described sinusoidal signal generator comprises phase accumulator, waveform ROM and D/A converter; The outfan of the input connection handling device of phase accumulator, the outfan of phase accumulator connects the input of waveform ROM, and the outfan of waveform ROM connects the input of D/A converter, and the outfan of D/A converter connects the input of prime wave filter.
The low intensity pulsed ultrasound parameter that described ultrasonic transducer exports is A, and namely hyperacoustic intensity is 30mW/cm
2, frequency is 1.5MHz, pulse width is 200 μ s, and repetition rate is 1KHz, adopts parameter to be that the low intensity pulsed ultrasound of A stimulates cartilage, and then promotes the growth of cartilage or delay cartilage degradation speed.
Described controllable gain amplification module is used for obtaining peak value according to the output signal of signal generator module and is 7.6V and peak-to-peak value is the sine wave signal of the 1.5MHz of 15.2V.
Described signal generator module is for generation of the sine wave signal of frequency 1.5MHz.
The sine wave signal that described PWM analog switch module is used for signal generator module produces carries out pulsewidth modulation, and obtaining repetition rate is 1KHz, and pulse width is 200 μ s and dutycycle is the ultrasonic signal of 20%.
Described controllable gain amplification module exports by its D/A change-over circuit the gain amplification that variable magnitude of voltage carries out sinusoidal signal according to processor.
Described inductance capacitance match circuit, for realizing the variable resistance function of ultrasonic transducer, adopts series inductance to reach the object of impedance matching to ultrasonic transducer, and then makes ultrasonic transducer produce 1.5MHz ultrasound wave.
The control method of the described cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound, is characterized in that, comprise the following steps:
Step 1: produce control signal by processor module, sinusoidal signal generator produces the sine wave signal of required frequency 1.5MHz;
Step 2: the sinusoidal signal that sinusoidal signal generator produces enters controllable gain amplifier after prime filter filtering, exports by D/A change-over circuit the gain amplification that variable magnitude of voltage controls sinusoidal signal by processor;
Step 3: the signal after gain is amplified carries out power amplification through power amplification circuit again;
Step 4: produce that frequency is 1KHz, pulse width is 200 μ s by processor timer internal and dutycycle be 20% pwm pulse signal controls PWM analog switch module, make output signal for repetition rate is 1KHz, pulse width is 200 μ s, signal frequency is 1.5MHz pulsed sine wave signal;
Step 5: pulsed sine wave signal is after inductance capacitance match circuit passes to ultrasonic transducer, output parameter is the low intensity pulsed ultrasound of A, the cartilage of this ultrasonic stimulation damaged and then promotion cartilage-derived growth, or the knee cartilage of old people is stimulated, and then delay its cartilage degradation.
Beneficial effect:
The present invention, in conjunction with relevant animal experimental result, determines that design strength is 30mW/cm
2, frequency is 1.5MHz, and pulse width is 200 μ s, and repetition rate is the low intensity pulsed ultrasound cartilage rehabilitation stimulating apparatus of 1KHz, carries out stimulation therapy to damaged cartilage.The rehabilitation of damaged cartilage can be promoted under this parameter low intensity pulsed ultrasound stimulates, delay senile knee cartilage and degenerate.The present invention can be adopted to be that the cartilage injury patient of all ages and classes and the cause of disease formulates stimulation protocol, namely to determine the position that stimulates and duration, to help cartilage injury's patients ' recovery or to reach the object delaying senile knee cartilage and degenerate.It should be noted that, direct object of the present invention is not obtain diagnostic result or health status, and is only to provide device and the control method thereof that can promote the rehabilitation of damaged cartilage under a kind of low intensity pulsed ultrasound stimulates, and does not carry out medical diagnosis.
Accompanying drawing explanation
Fig. 1 is the cartilage rehabilitation stimulating apparatus structured flowchart based on low intensity pulsed ultrasound of one embodiment of the present invention;
Fig. 2 is the ultrasonic signal generator structural representation of one embodiment of the present invention;
Fig. 3 is that the DDS of one embodiment of the present invention produces waveform process schematic;
Fig. 4 is DSP and the AD9833 hardware connecting circuit figure of one embodiment of the present invention;
Fig. 5 is the active low-pass filter circuit theory diagrams of one embodiment of the present invention;
Fig. 6 is the AD603 internal structure schematic diagram of one embodiment of the present invention;
Fig. 7 is the generation 0dB to+40dB of one embodiment of the present invention, the AD603 chip connection figure of 30MHz bandwidth;
Fig. 8 is the signal generator module principle figure of one embodiment of the present invention;
Fig. 9 is the power amplifier module schematic diagram of one embodiment of the present invention;
Figure 10 is the PWM analog switch module principle figure of one embodiment of the present invention;
Figure 11 is the PWM analog switch output waveform schematic diagram of one embodiment of the present invention;
Figure 12 is the controllable gain amplification module schematic diagram of one embodiment of the present invention;
Figure 13 is the theoretic equivalent circuit diagram of ultrasonic transducer of one embodiment of the present invention;
The equivalent circuit diagram of the ultrasonic transducer that Figure 14 (a) is one embodiment of the present invention;
The ultrasonic transducer that Figure 14 (b) is one embodiment of the present invention and inductance capacitance match circuit figure thereof;
Equivalent circuit under the ultrasonic transducer resonant condition that Figure 14 (c) is one embodiment of the present invention;
Figure 15 is the ultrasonic transducer of one embodiment of the present invention and the artificial circuit figure of inductance capacitance match circuit thereof;
The amplitude-frequency characteristic figure of the ultrasonic transducer impedance analysis that Figure 16 (a) is one embodiment of the present invention;
The phase-frequency characteristic figure of the ultrasonic transducer impedance analysis that Figure 16 (b) is one embodiment of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiments of the present invention are described in further detail.
A kind of cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound, as shown in Figure 1, comprising: processor module, signal generator module, PWM analog switch module, controllable gain amplification module, power amplifier, inductance capacitance match circuit and ultrasonic transducer;
The control input end of the control output end difference connection signal generator module of processor module, the control input end of controllable gain amplification module and the control input end of PWM analog switch module, the outfan of signal generator module connects the input of controllable gain amplification module, the outfan of controllable gain amplification module connects the input of power amplifier, the outfan of power amplifier connects the input of PWM analog switch module, the outfan of PWM analog switch module connects the input of inductance capacitance match circuit, the outfan of inductance capacitance match circuit connects the input of ultrasonic transducer, the low intensity pulsed ultrasound that ultrasonic transducer exports acts on cartilage, and then promote the growth of cartilage or delay cartilage degradation speed.
Signal generator module comprises sinusoidal signal generator and prime wave filter; Adopt TMS320F2812 control AD9833 chip and add MC34071 chip in rear class, as shown in Figure 8;
Processor module controls the sinusoidal signal that sinusoidal signal generator produces 1.5MHz, processor module connects sinusoidal signal generator and PWM analog switch module by serial line interface, the outfan of sinusoidal signal generator connects the input of prime wave filter, and the outfan of prime wave filter connects the input of controllable gain amplification module.
Sinusoidal signal generator adopts the low-power consumption of being produced by ADI company, programmable waveform generator AD9833, and it can produce sine wave, triangular wave, square wave output.Operating voltage range is 2.3V ~ 5.5V, is that 25MHz situation lower frequency range can reach 0MHz ~ 12.5MHz and frequency and phase place can digital programmables, meets low-power consumption, produce the requirement of 1.5MHz pulse, and can realize the dynamic adjustments of frequency at dominant frequency clock.
First, according to direct digital synthesis technique (Direct Digital Synthesizer, DDS) principle, utilize TMS320F2812 control AD9833 chip design to complete signal generator module; Adopt AD603 chip, utilize the software-controllable characteristic of chip, adopt the design of two-stage series connection cascade system to achieve controllable gain amplification module; Adopt AD811 chip, utilize its low noise, low distortion, wide bandwidth characteristic, design achieves power amplifier module; Utilize TMS320F2812 to produce pwm pulse modulation, achieve PWM analog switch module with analog switch chip design.Finally complete the design of low intensity pulsed ultrasound rehabilitation stimulating apparatus.
As shown in Figure 2, sinusoidal signal generator comprises phase accumulator, waveform ROM and D/A converter; The outfan of the input connection handling device of phase accumulator, the outfan of phase accumulator connects the input of waveform ROM, and the outfan of waveform ROM connects the input of D/A converter, and the outfan of D/A converter connects the input of prime wave filter.
Control signal output frequency is carried out by programming setup control word K, operation principle is by frequency division or frequency multiplication by the derived reference signal of input, thus obtain final required frequency, it produces waveform principle is according to Nyquist (Nyquist) sampling theorem and Digital Signal Processing, corresponding phase information is found by being kept at the mode of the sinusoidal wave data in waveform ROM by look-up table, finally, analog sine wave signal is obtained by D/A converter and prime wave filter, and Fig. 3 shows DDS and frequency control word K is converted into output frequency f
0process.
DDS output signal frequency f
0, reference clock frequency f
c, phase accumulator figure place N and frequency control word K relation as follows:
f
0＝(K×f
c)/2
N
The minimum frequency resolution of DDS is:
Δf
min＝f
c/2
N
When needs change output signal frequency, as long as change frequency control word, to make it output frequency therewith corresponding, and when next clock arrives, accumulator just can add up using new frequency control word as step-length.From above formula, when reference frequency f
cwith phase accumulator figure place N mono-timing, just can changing output frequency by changing frequency control word, when revising phase accumulator figure place N, just can realize any frequency resolution.
The signal frequency exported at about 1.5MHz, AD9833 chip due to desired signal frequency is unstable, carries out perfect further so present embodiment increases one-stage low-pass ripple to waveform.Present embodiment adopts active low-pass filter as prime wave filter, selects MC34071 chip.MC34071 has 4.5MHz bandwidth, can power by one pole, meets the demands.Low-pass filtering cut-off frequency is 3MHz.Active low-pass filter circuit as shown in Figure 5.
Processor adopts TMS320F2812 minimum system plate, transmits control word and work schedule by the GPIO mouth of TMS320F2812.TMS320F2812 is the dsp chips of a 32 fixed points, is the dsp chip of the high-performance for controlling, multi-functional, high performance-price ratio.The sinusoidal signal that the active crystal oscillator that the reference clock frequency that in present embodiment, AD9833 chip uses is 25MHz produces.The GPIOA0 (PWM1) of reference clock frequency SCLK and the TMS320F2812 that the input of AD9833 chip frequency word uses is connected; The GPIOA2 (PWM2) of AD9833 renewal frequency signal FSYNC and TMS320F2812 is connected; Outside reference clock frequency MCLK is connected with the output of active crystal oscillation signal.And the control word write of AD9833 is realized by the GPIOA1 (PWM3) of TMS320F2812, writing mode is serial mode, can realize the output of the signal of different frequency and out of phase by writing different control words.Control word is write by the clock signal of SCLK and FSYNC, its clock signal is simulated by programming Control GPIO mouth, just control word can be write AD9833 in conjunction with the control word sent and clock signal to realize controlling it, realize the output of the good sine wave signal of outfan.DSP produces sine wave signal by three serial line interface Based Intelligent Control AD9833 chips, and hardware connecting circuit as shown in Figure 4.
Low intensity pulsed ultrasound (low-intensity pulsed ultrasound, LIPUS) can promote the reparation of bone and cartilage injury.Present embodiment determines ultrasonic parameters according to bioassay results, and namely intensity is 30mW/cm2, frequency is 1.5MHz, pulse width be 200 μ s and repetition rate is 1KHz.
The cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound of present embodiment obtains by controllable gain amplification module the 1.5MHz sine wave that peak value is 7.6V (peak-to-peak value is 15.2V), drives ultrasonic transducer to send required low intensity pulsed ultrasound through PWM analog switch, power amplifier, inductance capacitance match circuit.
As shown in figure 12, controllable gain amplification module adopts series connection two-stage to amplify mode, sets, thus sets its amplification, reach required designing requirement according to the selection of input voltage.
Controllable gain amplification module adopts AD603 chip to carry out gain amplification, and the pin list of AD603 is in table 1.AD603 internal structure schematic diagram as shown in Figure 6, this chip internal comprises three parts, be respectively control module, R-2R trapezoid resistance network and fixed gain amplifier, input signal is inputted by ladder network, after overdamping, export from fixed gain amplifier end, the reference voltage of gain control interface can control its attenuation, control interface with DSP through to calculate and the voltage exported by D/A chip is connected, can carry out the Based Intelligent Control of attenuation thus.The bandwidth of operation of AD603 can reach KHz level to 30MHz in addition, only has the gain that can reach about 40dB during one-level amplifier, and two-stage cascade amplifies the gain that can reach about 80dB.
The pin list of table 1AD603
When input VINP (i.e. chip 3 foot) input signal at ladder network, signal is decayed through ladder network, attenuation is only determined by the voltage difference between 1 foot of chip, 2 feet, amount of gain can determine very accurately, its structure provides a kind of linear gain effect, when control voltage is between-0.5V ~+0.5V, gain can realize linear increase.
Will carry out gain amplifying signal to be inputted by ladder network end, and decay through ladder network, its attenuation is by control end, and the voltage difference namely between foot 1 and foot 2 controls, and its voltage difference is called as VG, and attenuation can reach 40dB/V, i.e. 25mV/dB.
Because the fixed gain amplifier gain in chip AD603 is determined by foot 5 (FDBK) and foot 7 (VOUT), adopt method of attachment as shown in Figure 7,5 feet of AD603,7 feet connect 2k Ω resistance, 4 foot ground connection, the first order realizes gain 36.5dB, and produces the 10MHz bandwidth being greater than system requirements.
Power amplifier schematic diagram as shown in Figure 9.Present embodiment adopts AD811 integrated power amplification chip as power amplifier, and the running voltage of this chip can reach 15V, and its amplification can keep stable when frequency is higher, and has low noise and other advantages, basic satisfied amplification requirement.AD811 is the operational amplifier of a wideband current feedback-type, 120MHz bandwidth gain is-3dB, differential gain, phase error can reach 0.01% and 0.01 ° respectively, there is low differential gain and low phase error properties, it also meets the requirement of 0.1dB flat gain in addition, AD811 also has low current noise, high DC precision in addition, is also applicable to wide dynamic scope and uses.Due to the structure of its Current Negative Three-Point Capacitance, its bandwidth has feedback resistance to determine, can change bandwidth by the resistance changing feedback resistance.AD811 is dual power supply, and supply voltage can reach ± 4.5V ~ ± 18V.In order to determine final amplification, present embodiment adopts slide rheostat as feedback resistance, determines its amplification through experiment.
PWM analog switch module as shown in Figure 10.Be 1KHz to obtain repetition rate, dutycycle is the ultrasonic signal of 20%, and the sine wave signal sent needs through pulsewidth modulation.Because pwm signal is produced by TMS320F2812, sine wave signal is produced by signal generator module, only needs an extraneous analog switch.PWM analog switch model choice CD4051 chip in present embodiment.CD4501 chip allows digital signal to control it, and what can meet the analogue signal with positive and negative amplitude carries out accessible output.VEE and VCC determines the conducting resistance R of chip jointly, works as VCC=5V, during VEE=0V, and R=280 Ω; When VCC>10V, VEE=0V, R=100 Ω.When the value of VCC is higher, its conducting resistance is lower, but relative conducting digital signal also needs to improve its voltage, after circuit board testing, determine VEE sky to connect, VCC connects 5V voltage, the 3V positive voltage that PWM produces enough makes its conducting, and its conducting resistance also has no significant effect output signal.
Figure 11 is shown in by PWM analog switch output waveform schematic diagram.
The parameter A of low intensity pulsed ultrasound is: intensity is 30mW/cm
2, frequency is 1.5MHz, pulse width is 200 μ s, and repetition rate is 1KHz.Treatment time is every day N time, and each T minute, N=1, T=20 during beginning, user can adjust the value of N and T according to patient feedback.
The technical scheme of present embodiment is tested on circuit boards, programming and testing is carried out in Code Composer Studio 3.3, and devise the pcb board of schematic diagram and correspondence thereof, complete welding and the debugging of pcb board, complete the output that peak-to-peak value is the sine wave of 15.2V, meet the requirement of ultrasonic transducer.Well demonstrate enforceability of the present invention.
Control signal is produced by TMS320F2812 minimum system plate, control chip AD9833 produces required frequency 1.5MHz sine wave signal, this sinusoidal signal carries out gain amplification through controllable gain amplifier, its gain controls to be exported variable magnitude of voltage to control by D/A change-over circuit by TMS320F2812, and the signal after gain is amplified carries out power amplification through power amplification circuit again; Producing frequency by TMS320F2812 timer internal is 1KHz, dutycycle is the pwm pulse signal of 20%, control simulation switch realizes PWM analog switch module, make to output signal for repetition rate be 1KHz, signal frequency is the pulsed sine wave signal of 1.5MHz.This signal is after inductance capacitance match circuit passes to ultrasonic transducer, and just exportable parameter is the low intensity pulsed ultrasound of A.With the cartilage of this ultrasonic stimulation damaged, and then promote cartilage-derived growth; Or the knee cartilage of old people is stimulated, and then delay its cartilage degradation.
The theoretic equivalent circuit of ultrasonic transducer that present embodiment adopts, as shown in figure 13, C in figure
0for direct capacitance, in the parallel branch of ultrasonic transducer equivalent circuit, its value is passing through to measure and transducer static electric capacity in the frequency of resonant frequency, and it is mainly by dielectric constant and the electrode size decision of piezoelectric ceramics; L
1for dynamic inductance, be caused by transducer vibrations quality; C1 is dynamic capacity, expression be the mechanical compliance of transducer; R1 is the dynamic electric resistor of mechanical loss, and the branch road at L1, C1, R1 place is called as series arm.
In order to actual environment Dynamic Matching, through the equivalent circuit diagram of the ultrasonic transducer that emulation testing adopts Figure 14 (a) to be one embodiment of the present invention, and then obtain the ultrasound wave of 1.5Mhz.The ultrasonic transducer that Figure 14 (b) is one embodiment of the present invention and inductance capacitance match circuit figure thereof, inductance capacitance coupling can better realize the variable resistance function of transducer, and adopt series inductance to reach the object of impedance matching to ultrasonic transducer, inductance value can determine that ultrasonic transducer is under being operated in series resonance frequency, still under being operated in parallel resonance frequency, after inductance coupling, ultrasonic transducer can be equivalent to a pure resistance R, equivalent circuit under the ultrasonic transducer resonant condition that Figure 14 (b) is corresponding is as shown in Figure 14 (c).
In present embodiment, peak value is that the sine voltage of 7.6V can drive ultrasonic transducer to produce ultrasound wave, and when inductance capacitance match circuit makes voltage amplification factor be 3, the voltage peak that only need add inductance capacitance match circuit is 2.53V.
Figure 15 is the ultrasonic transducer of one embodiment of the present invention and the artificial circuit figure of inductance capacitance match circuit thereof, and wherein: inductance L=1 μ H, electric capacity C=9nF, C1=1nF, R1=30 Ω, sinusoidal signal frequency is 1.5MHz, and voltage peak is 2.53V.Illustrate that the value of inductance capacitance in this matching process can produce the sine waveform of 1.5Mhz through emulation testing.For Figure 15, emulate the impedance operator of ultrasonic transducer in the simlink in matlab, transducer impedance analysis result as shown in figure 16.The amplitude-frequency characteristic figure of the ultrasonic transducer impedance analysis that Figure 16 (a) is one embodiment of the present invention, the phase-frequency characteristic figure of the ultrasonic transducer impedance analysis that 16 (b) is one embodiment of the present invention.As seen from Figure 16, when the frequency inputing to transducer signal reaches its resonant frequency 1.5MHz, equiva lent impedance is close to 30 Ω, and phase-frequency characteristic is better, is null value.
The present invention's key is a kind of cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound of design, intelligent chip TMS320F2812 core board is utilized to control, produce the sine waveform of required frequency, after amplifying, obtain the signal of telecommunication of adjustable gain, deliver to ultrasonic transducer through inductance capacitance match circuit and produce ultrasound wave.
In the process of design circuit plate, as far as possible by the modules in design separately, the devices such as the chip that each module possesses, resistance, electric capacity, power supply, contact pin, are placed in a region as much as possible, facilitate the later stage to debug.In addition, power interface is placed on the side of circuit board as far as possible, arranges one by one in line with first big after small principle to components and parts.Mark is write clearly time schematic diagram is drawn, for later stage welding and debugging are all saved time as far as possible.The pcb board of the design is 10cm × 10cm size, is enough put onboard by all elements.
Based on the control method of the cartilage rehabilitation stimulating apparatus of low intensity pulsed ultrasound, comprise the following steps:
Step 1: produce control signal by processor module, sinusoidal signal generator produces the sine wave signal of required frequency 1.5MHz;
Step 2: the sinusoidal signal that sinusoidal signal generator produces enters controllable gain amplifier after prime filter filtering, exports by D/A change-over circuit the gain amplification that variable magnitude of voltage controls sinusoidal signal by processor;
Step 3: the signal after gain is amplified carries out power amplification through power amplification circuit again;
Step 4: produce that frequency is 1KHz, pulse width is 200 μ s by processor timer internal and dutycycle be 20% pwm pulse signal controls PWM analog switch module, make output signal for repetition rate is 1KHz, pulse width is 200 μ s, signal frequency is 1.5MHz pulsed sine wave signal;
Step 5: pulsed sine wave signal is after inductance capacitance match circuit passes to ultrasonic transducer, output parameter is the low intensity pulsed ultrasound of A, the cartilage of this ultrasonic stimulation damaged and then promotion cartilage-derived growth, or the knee cartilage of old people is stimulated, and then delay its cartilage degradation.
Although the foregoing describe the specific embodiment of the present invention, one skilled in the art should be appreciated that these only illustrate, can make various changes or modifications, and do not deviate from principle of the present invention and essence to these embodiments.Scope of the present invention is only defined by the appended claims.
Claims (10)
1. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound, it is characterized in that, comprising: processor module, signal generator module, PWM analog switch module, controllable gain amplification module, power amplifier, inductance capacitance match circuit, ultrasonic transducer;
The control input end of the control output end difference connection signal generator module of processor module, the control input end of controllable gain amplification module and the control input end of PWM analog switch module, the outfan of signal generator module connects the input of controllable gain amplification module, the outfan of controllable gain amplification module connects the input of power amplifier, the outfan of power amplifier connects the input of PWM analog switch module, the outfan of PWM analog switch module connects the input of inductance capacitance match circuit, the outfan of inductance capacitance match circuit connects the input of ultrasonic transducer, the low intensity pulsed ultrasound that ultrasonic transducer exports acts on cartilage.
2. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, it is characterized in that, described signal generator module comprises sinusoidal signal generator and prime wave filter;
Processor module controls the sinusoidal signal that sinusoidal signal generator produces 1.5MHz, processor module connects sinusoidal signal generator and PWM analog switch module by serial line interface, the outfan of sinusoidal signal generator connects the input of prime wave filter, and the outfan of prime wave filter connects the input of controllable gain amplification module.
3. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 2, it is characterized in that, described sinusoidal signal generator comprises phase accumulator, waveform ROM and D/A converter; The outfan of the input connection handling device of phase accumulator, the outfan of phase accumulator connects the input of waveform ROM, and the outfan of waveform ROM connects the input of D/A converter, and the outfan of D/A converter connects the input of prime wave filter.
4. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, is characterized in that, the low intensity pulsed ultrasound parameter that described ultrasonic transducer exports is A, and namely hyperacoustic intensity is 30mW/cm
2, frequency is 1.5MHz, pulse width is 200 μ s, and repetition rate is 1KHz, adopts parameter to be that the low intensity pulsed ultrasound of A stimulates cartilage, and then promotes the growth of cartilage or delay cartilage degradation speed.
5. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, it is characterized in that, described controllable gain amplification module is used for obtaining peak value according to the output signal of signal generator module and is 7.6V and peak-to-peak value is the sine wave signal of the 1.5MHz of 15.2V.
6. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, it is characterized in that, described signal generator module is for generation of the sine wave signal of frequency 1.5MHz.
7. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, it is characterized in that, the sine wave signal that described PWM analog switch module is used for signal generator module produces carries out pulsewidth modulation, obtaining repetition rate is 1KHz, and pulse width is 200 μ s and dutycycle is the ultrasonic signal of 20%.
8. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, it is characterized in that, described controllable gain amplification module exports by its D/A change-over circuit the gain amplification that variable magnitude of voltage carries out sinusoidal signal according to processor.
9. the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, it is characterized in that, described inductance capacitance match circuit is for realizing the variable resistance function of ultrasonic transducer, adopt series inductance to reach the object of impedance matching to ultrasonic transducer, and then make ultrasonic transducer produce 1.5MHz ultrasound wave.
10. the control method of the cartilage rehabilitation stimulating apparatus based on low intensity pulsed ultrasound according to claim 1, is characterized in that, comprise the following steps:
Step 1: produce control signal by processor module, sinusoidal signal generator produces the sine wave signal of required frequency 1.5MHz;
Step 2: the sinusoidal signal that sinusoidal signal generator produces enters controllable gain amplifier after prime filter filtering, exports by D/A change-over circuit the gain amplification that variable magnitude of voltage controls sinusoidal signal by processor;
Step 3: the signal after gain is amplified carries out power amplification through power amplification circuit again;
Step 4: produce that frequency is 1KHz, pulse width is 200 μ s by processor timer internal and dutycycle be 20% pwm pulse signal controls PWM analog switch module, make output signal for repetition rate is 1KHz, pulse width is 200 μ s, signal frequency is 1.5MHz pulsed sine wave signal;
Step 5: pulsed sine wave signal is after inductance capacitance match circuit passes to ultrasonic transducer, output parameter is the low intensity pulsed ultrasound of A, the cartilage of this ultrasonic stimulation damaged and then promotion cartilage-derived growth, or the knee cartilage of old people is stimulated, and then delay its cartilage degradation.
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| CN106039600A (en) * | 2016-05-17 | 2016-10-26 | 西安交通大学 | Wirelessly-controlled wearable ultrasonic nerve stimulation apparatus |
| CN106344119A (en) * | 2016-10-25 | 2017-01-25 | 厚凯（天津）医疗科技有限公司 | Direct excitation type ultrasonic power driving system |
| CN107296993A (en) * | 2017-06-14 | 2017-10-27 | 成都润泰智通科技有限公司 | Using the Wound treatment apparatus of phase difference technology |
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| WO2021052356A1 (en) * | 2019-09-16 | 2021-03-25 | The Hong Kong Polytechnic University | Bone stimulartor and bone stimulation system for bone fracture healing |
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| CN106039600A (en) * | 2016-05-17 | 2016-10-26 | 西安交通大学 | Wirelessly-controlled wearable ultrasonic nerve stimulation apparatus |
| CN106344119A (en) * | 2016-10-25 | 2017-01-25 | 厚凯（天津）医疗科技有限公司 | Direct excitation type ultrasonic power driving system |
| CN107296993A (en) * | 2017-06-14 | 2017-10-27 | 成都润泰智通科技有限公司 | Using the Wound treatment apparatus of phase difference technology |
| CN109224325A (en) * | 2018-08-17 | 2019-01-18 | 广州合舜医疗器械有限公司 | A kind of finishing impression instrument driving circuit |
| CN110465005A (en) * | 2019-08-20 | 2019-11-19 | 青岛市即墨区人民医院 | A kind of eye treatment device |
| WO2021052356A1 (en) * | 2019-09-16 | 2021-03-25 | The Hong Kong Polytechnic University | Bone stimulartor and bone stimulation system for bone fracture healing |
| CN112754604A (en) * | 2019-11-05 | 2021-05-07 | 重庆迈科唯医疗科技有限公司 | Ultrasonic knife host, ultrasonic knife system and automatic matching method for impedance of transducer of ultrasonic knife system |
| CN112754604B (en) * | 2019-11-05 | 2022-02-01 | 重庆迈科唯医疗科技有限公司 | Ultrasonic knife host, ultrasonic knife system and automatic matching method for impedance of transducer of ultrasonic knife system |
| CN112535809A (en) * | 2020-12-01 | 2021-03-23 | 成都沃特塞恩电子技术有限公司 | Power regulation system and short wave therapeutic instrument |
| CN112535809B (en) * | 2020-12-01 | 2021-08-24 | 成都沃特塞恩电子技术有限公司 | Power regulation system and short wave therapeutic instrument |
| CN114674180A (en) * | 2022-03-21 | 2022-06-28 | 北京北科烁普科技有限公司 | Video monitoring type directional sound wave dispersing device based on wireless transmission |
| CN114674180B (en) * | 2022-03-21 | 2023-08-18 | 北京北科烁普科技有限公司 | Video monitoring type directional sound wave dispersing device based on wireless transmission |
| CN115192926A (en) * | 2022-07-13 | 2022-10-18 | 苏州思萃电子功能材料技术研究所有限公司 | Self-adaptive ultrasonic bone repair treatment system and treatment method |
| CN116439231A (en) * | 2023-06-09 | 2023-07-18 | 山东第一医科大学(山东省医学科学院) | Ultrasonic stimulation method for improving preservation effect of in-vitro bone cartilage tissue |
| CN116439231B (en) * | 2023-06-09 | 2023-09-19 | 山东第一医科大学(山东省医学科学院) | Ultrasonic stimulation method for improving preservation effect of in-vitro bone cartilage tissue |
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