CN104662164A - 缺氧诱导因子(hif)活性报告细胞系 - Google Patents

缺氧诱导因子(hif)活性报告细胞系 Download PDF

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Publication number
CN104662164A
CN104662164A CN201380040870.5A CN201380040870A CN104662164A CN 104662164 A CN104662164 A CN 104662164A CN 201380040870 A CN201380040870 A CN 201380040870A CN 104662164 A CN104662164 A CN 104662164A
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China
Prior art keywords
hif
cells
cell
gene
cell line
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Pending
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CN201380040870.5A
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English (en)
Chinese (zh)
Inventor
诺拉兹哈·莎菲
艾瑞克·J·斯坦布里奇
哈提嘉·尤索夫
刘显烨
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Universiti Putra Malaysia (UPM)
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Universiti Putra Malaysia (UPM)
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Filing date
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Application filed by Universiti Putra Malaysia (UPM) filed Critical Universiti Putra Malaysia (UPM)
Publication of CN104662164A publication Critical patent/CN104662164A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/505—Erythropoietin [EPO]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7038—Hypoxia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201380040870.5A 2012-08-02 2013-01-29 缺氧诱导因子(hif)活性报告细胞系 Pending CN104662164A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
MYPI2012003492 2012-08-02
MYPI2012003492A MY172311A (en) 2012-08-02 2012-08-02 Hypoxia inducible factor (hif) activity reporter cell line
PCT/MY2013/000013 WO2014021705A1 (en) 2012-08-02 2013-01-29 Hypoxia inducible factor (hif) activity reporter cell line

Publications (1)

Publication Number Publication Date
CN104662164A true CN104662164A (zh) 2015-05-27

Family

ID=48040394

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380040870.5A Pending CN104662164A (zh) 2012-08-02 2013-01-29 缺氧诱导因子(hif)活性报告细胞系

Country Status (7)

Country Link
US (1) US9995730B2 (https=)
EP (1) EP2880177B1 (https=)
JP (1) JP6309520B2 (https=)
CN (1) CN104662164A (https=)
IN (1) IN2015DN00205A (https=)
MY (1) MY172311A (https=)
WO (1) WO2014021705A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101849964B1 (ko) * 2016-07-26 2018-04-19 울산대학교 산학협력단 Il-7 발현 리포터 세포주 및 이를 이용한 면역결핍 질환 치료제 스크리닝 방법
AU2021240417A1 (en) * 2020-03-26 2022-10-20 AskBio Inc. Forskolin-inducible promoters and hypoxia-inducible promoters

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037390A1 (en) * 2003-06-04 2005-02-17 Irm Llc, A Delaware Limited Liability Company Methods and compositions for modulating erythropoietin expression

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834306A (en) * 1994-12-23 1998-11-10 Sri International Tissue specific hypoxia regulated therapeutic constructs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037390A1 (en) * 2003-06-04 2005-02-17 Irm Llc, A Delaware Limited Liability Company Methods and compositions for modulating erythropoietin expression

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KALUZ ET AL.: "Rational design of minimal hypoxia-inducible enhancers", 《BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS》 *
KEN ET AL.: "The expression of erythropoietin triggered by Danggui Buxue Tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells", 《JOURNAL OF ETHNOPHARMACOLOGY》 *
KEN Y.Z. ZHENG等: "he expression of erythropoietin triggered by Danggui Buxue Tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells", 《JOURNAL OF ETHNOPHARMACOLOGY》, vol. 132, 17 August 2010 (2010-08-17), pages 259 - 267, XP 027417957 *
MORWENNA ET AL.: "Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit(HIF-1α)", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 *
SHIBATA T 等: "Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes", 《INTERNATIONAL JOURNAL OF RADIATION：ONCOLOGY BIOLOGY PHYSICS》, vol. 42, no. 2, 1 November 1998 (1998-11-01), pages 913 - 916, XP 002975914, DOI: doi:10.1016/S0360-3016(98)00298-3 *

Also Published As

Publication number Publication date
MY172311A (en) 2019-11-21
US20150168376A1 (en) 2015-06-18
EP2880177B1 (en) 2017-07-19
JP6309520B2 (ja) 2018-04-11
IN2015DN00205A (https=) 2015-06-12
WO2014021705A1 (en) 2014-02-06
JP2015524272A (ja) 2015-08-24
EP2880177A1 (en) 2015-06-10
US9995730B2 (en) 2018-06-12

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Application publication date: 20150527