CN104649996B - Isothiazole oxime ether derivatives as well as preparation method and application thereof - Google Patents
Isothiazole oxime ether derivatives as well as preparation method and application thereof Download PDFInfo
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- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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Abstract
The invention provides isothiazole oxime ether derivatives as well as a preparation method and an application thereof, and relates to isothiazole oxime ether compounds. The isothiazole oxime ether derivatives have a chemical structure formula as shown in III. The invention discloses a structure general formula and a synthesis method of the compounds and an application of the compounds as insecticides, fungicides, anti-plant virus agents and plant activators, and an application and a preparation method of the compounds and agriculturally acceptable assistants or synergists and commercial insecticides, acaricides, fungicides, anti-plant virus agents and plant activators applied to prevention and treatment of diseases, insect pests, mites and virus diseases in agriculture, forestry and horticulture in combination.
Description
Technical field
Technical scheme is related to contain the heterocyclic compound of S and in particular to 3,4- bis- chloroisothiazole class chemical combination containing N
Thing, i.e. 3,4- bis- chloroisothiazole oxime ether derivatives.
Background technology
Heterocyclic compound has an extensive biological activity, and the bioactive compound major part of patent literature is miscellaneous
Cycle compound.Different thiazoles compound has extensive biological activity, and in 1988, Melnikov noted in pesticide research work
Potential extensive biological activity (Mel ' the nikov N.N.Basic current trends in the of isothiazole compounds of anticipating
development of production and use of chemical agents for protection of plants
and plant growth regulators.Zhurnal Vseoyuznogo Khimic heskogo Obshchestva
Im.D.I.Mendeleeva.1988,33 (6), 602-609.).Isothiazole compounds are widely used in grinding of pesticide and medical product
Study carefully exploitation (Engel, Stefan.et al.WO 9738987.1997-10-23).The kind of viable commercial product has：Antibacterial
Benziothiazolinone (benziothiazolinone), allyl isothiazole (probenazole), isotianil (isotianil) (quiet.
There is the different thiazoles compound progress of biological activity. pesticide, 2011,50 (3)：157-158.)
In order to find and find more efficiently, wide spectrum, low toxicity, low ecological risk and with existing antibacterial no interactions resistance
Novel pesticide guide, present invention design has synthesized class isothiazole oxime ether derivatives, has carried out the sieve of the biological activity of system simultaneously
Choosing and evaluation, provide high activity candidate compounds to studying for New pesticides discovery.
Content of the invention
The technical problem to be solved is：The synthetic method of the new isothiazole oxime ether derivatives of one class is provided, carries
Biological activity for this kind of compound modulates agricultural, gardening and health and forestry plant insect and the phytopathy original and its mensure
Method, provides these compounds in the middle application of agriculture field, horticultural field, field of forestry and health field simultaneously.
The present invention solves this technical problem and be employed technical scheme comprise that：There is agriculture field, horticultural field, field of forestry
Parasite killing, acaricidal activity, bactericidal activity, anti-phytoviral activity, induction plant produce 3, the 4- bis- chloroisothiazole oxime of anti-disease activity
The chemical structure of general formula of ether compound is shown in formula III：
Wherein, R1It is selected from：Hydrogen, amino, methyl；R2It is selected from：Hydrogen, methyl, ethyl, 2- chloroethyl, pi-allyl, propargyl, 2-
Butine -1- base, 2- octyne -1- base, 2- TRIFLUOROMETHYLBENZOYL.
The synthetic method of 3, the 4- bis- chloroisothiazole oxime ether derivatives III of the present invention is as follows：
Wherein, R1It is selected from：Hydrogen, amino, methyl；R2It is selected from：Hydrogen, methyl, ethyl, 2- chloroethyl, pi-allyl, propargyl, 2-
Butine -1- base, 2- octyne -1- base, 2- TRIFLUOROMETHYLBENZOYL
As above, shown in reaction equation, compound III, according to the difference of reaction raw materials I, can be added with hydroxylamine hydrochloride with cyano group
Become, the method preparation of aldehydes or ketones and hydroxylamine hydrochloride condensation reaction.
The concrete grammar of the synthesis of the compounds of this invention and biological activity determination is divided into following steps：
A. the preparation of compound II：
Add 1.12 mMs of compound I in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of ethanol, add
2.24 mMs of oxammonium hydrochloride .s, 0.11 gram of Deca triethylamine in final reaction system, that is, 1.12 mMs, it is stirred at room temperature 1 hour,
Removal of solvent under reduced pressure after reaction completely, with 10 milliliters of diluted ethyl acetate, adds 10 milliliters of water, isolates organic layer,
Twice of aqueous layer with ethyl acetate back extraction, merges organic layer, and organic layer saturated sodium-chloride is washed one time, and anhydrous sodium sulfate drying is taken out
Filter, removal of solvent under reduced pressure, residue obtains compound II through 200～300 mesh silica gel column chromatography purification, and eluant is Celsius for 60～90
The petroleum ether of degree: ethyl acetate, according to the difference of product, volume ratio is 9: 1 to 2: 1, yield 80-95%；Prepared by compound II
Amount and the volume of reaction vessel expand or shrink by corresponding proportion；The chemical constitution of compound II and physical and chemical parameter are shown in Table 1.
B. the preparation method one of part of compounds III：
Add 1.02 mMs of compound II in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of acetonitriles, to reaction
Middle add 0.21 gram, i.e. 1.53 mMs of potassium carbonate, add 1.53 mMs of R in the most backward reaction system2- X, is stirred at room temperature
Overnight, reactant liquor is concentrated after terminating by reaction, and residue, with 10 milliliters of diluted ethyl acetate, adds 10 milliliters of water that solid is complete
Portion dissolves, and isolates organic layer, aqueous layer with ethyl acetate back extraction one time, merges organic layer, organic layer saturated sodium-chloride washes one
Time, anhydrous sodium sulfate drying, sucking filtration, removal of solvent under reduced pressure, residue obtains compound through 200～300 mesh silica gel column chromatography purification
III, eluant is 60～90 degrees Celsius of petroleum ether: ethyl acetate, and according to the difference of product, volume ratio is 20: 1 to 8: 1, receives
Rate 25-85%；The volume of the amount of compound III preparation and reaction vessel is expanded or shunk by corresponding proportion；The change of compound III
Learn structure and physical and chemical parameter is shown in Table 1.
C. the preparation method two of part of compounds III：
Add 2.36 mMs of compound II in 25 milliliters of single necked round bottom flask, with 5 milliliters of DMFs
Dissolving, adds 1.15 grams in reaction, i.e. 3.54 mMs of cesium carbonates add 3.54 mMs in the most backward reaction system
R2- X, is stirred at room temperature 2 hours, after reaction terminates, adds 10 milliliters of water in reactant liquor, is extracted with ethyl acetate, isolates
Organic layer, twice of aqueous layer with ethyl acetate back extraction, merge organic layer, organic layer saturated sodium-chloride washes one time, anhydrous sodium sulfate
It is dried, sucking filtration, removal of solvent under reduced pressure, residue obtains white solid through 200～300 mesh silica gel column chromatography purification, and eluant is
60～90 degrees Celsius of petroleum ether: ethyl acetate, volume ratio is 20: 1, yield 23%；The amount of compound III preparation and reaction are held
The volume of device is expanded or shunk by corresponding proportion.The chemical constitution of compound III and physical and chemical parameter are shown in Table 1.
D. the preparation method three of part of compounds III：
Add 1.03 mMs of compound II in 50 milliliters of single necked round bottom flask, the dichloromethane with 25 milliliters of dryings is molten
Solution, then to 0.13 gram of Deca triethylamine in reaction system, that is, 1.24 mMs, ice bath stirs 15 minutes, under ice bath stirring
In backward reaction system, Deca is dissolved in 1.24 mMs in 10 milliliters of dry methylene chloride of compound R2- X, was stirred at room temperature
At night, reactant liquor is concentrated after terminating by reaction, and residue from dichloromethane dissolves, and organic layer uses saturated sodium bicarbonate, saturation successively
Saline solution is respectively washed one time, anhydrous sodium sulfate drying, sucking filtration, and rotary evaporation removes solvent, and residue is through 200～300 mesh silicagel columns
Chromatography purification obtains white solid, and eluant is 60～90 degrees Celsius of petroleum ether: ethyl acetate, and volume ratio is 20: 1, yield
60-70%；The volume of the amount of compound III preparation and reaction vessel is expanded or shunk by corresponding proportion.The chemistry of compound III
Structure and physical and chemical parameter are shown in Table 1.
E. the preparation method four of part of compounds III：
Add 0.55 mM of compound I in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of ethanol, then to reaction
1.10 mMs of NH of middle addition2OR2HCl, 0.11 gram of Deca triethylamine in final reaction system, that is, 1.10 mMs, room temperature is stirred
Mix 1 hour, removal of solvent under reduced pressure after reaction completely, with diluted ethyl acetate, add a small amount of water, isolate organic layer, water
Layer ethyl acetate back extraction one time, merges organic layer, and organic layer saturated sodium-chloride is washed one time, anhydrous sodium sulfate drying, sucking filtration,
Removal of solvent under reduced pressure, residue obtains compound III through 200～300 mesh silica gel column chromatography purification, and eluant is 60～90 degrees Celsius
Petroleum ether: ethyl acetate, according to the difference of product, volume ratio is 20: 1 to 9: 1, yield 60-95%；Prepared by compound III
Amount and the volume of reaction vessel expand or shrink by corresponding proportion；The chemical constitution of compound III and physical and chemical parameter are shown in Table 1.
F. the bactericidal activity of the isothiazole oxime ether derivatives of the present invention measures：
The sterilization of isothiazole oxime ether derivatives III of the present invention or bacteriostatic activity adopt thalli growth rate algoscopy, specifically
Step is：1.8 milligrams of samples are taken to be dissolved in 2 dimethylformamides, then with the water containing a certain amount of polysorbas20 emulsifying agent
Solution is diluted to the medicament of 500 mcg/ml, reagent agent is aseptically respectively drawn 1 milliliter in culture dish, then divides
Not Jia Ru 9 milliliters of PDA culture mediums, make 50 mcg/ml pastille flat boards after shaking up, done with the flat board adding 1 milliliter of aquesterilisa
Blank, cuts bacterium disk with 4 millimeters of card punch of diameter along mycelia outer rim, moves on pastille flat board, puts in equilateral triangle
Put, often process and be repeated 3 times, culture dish is placed on culture in 24 ± 1 degrees Celsius of constant incubators, colony diameter to be compareed expands to
Investigate each process bacterium disk extension diameter after 2-3 centimetre, average, compare the relative bacteriostasis rate of calculating with blank, for trying bacterium
Plant the kind of the most of typical plant pathogen actually occurring for field in China's agricultural production, its title and code name are as follows：
AS：Tomato early blight bacterium, its Latin is entitled：Alternaria solani、BC：Botrytis cinerea pers, its Latin is entitled：
Botrytis cinerea、CA：Peanut Cercospora bacteria, its Latin is entitled：Cercospora arachidicola、GZ：Semen Tritici aestivi is red
Mould pathogenic bacteria, its Latin is entitled：Gibberella zeae、PI：Phytophthora infestans, its Latin is entitled：Phytophthora
infestans(Mont.)de Bary、PP：Botryosphaeria berengeriana f. sp, its Latin is entitled：Physalospora piricola、PS：
Rhizoctonia solani Kuhn, its Latin is entitled：Pellicularia sasakii、RC：Rhizoctonia cerealis, its Latin is entitled：
Rhizoctonia cerealis、SS：Sclerotinia sclerotiorum, its Latin is entitled：Sclerotinia sclerotiorum.
G. the inducing anti-disease activity of the isothiazole oxime ether derivatives of the present invention measures：
The screening technique of activity is as follows, and tobacco mosaic virus (TMV) is abbreviated as TMV：
(1). positive control activating plants agent：The tiadinil that quality purity purity is more than 99.5% is selected to be positive control
Activating plants agent；Tiadinil is abbreviated as TDL；
(2). the screening technique of the evoking tobacco anti-TMV activity of isothiazole oxime ether derivatives：Direct antiviral activity in vitro
Mensure carried out using half leaf method；Live body induction is by common cigarette consistent for seedling age, and 3 basins are one group, before first 7 days of inoculation
The tobacco seedlings processing, processing mode includes：Spray test compounds solution 2 to 3 times, 10 milliliters every time, or soil treatment, every time
10 milliliters, mensure concentration is 100 mcg/ml, the 7th day frictional inoculation TMV on the Nicotiana tabacum L. newly growing, and tobacco seedlings are placed in its life
After cultivating 3 days under long preference temperature and illumination, check incidence, comprehensive scab number is calculated as follows out test compound pair
The induction antiviral effect of TMV, each process sets 3 repetitions, and blank and standard agent comparison select water and TDL respectively：
Wherein, R is the inducing effect of noval chemical compound TMV anti-to Nicotiana tabacum L., unit：%；CK compares the average of blade for clear water
Withered spot number, unit：Individual；I is to induce the average withered spot number processing rear blade, unit through compound：Individual；
In addition to carrying out the mensure of above-mentioned induced activity, carried out controlling of the aminothiazole anti-TMV of carboxylic acid derivates IV simultaneously
Treat activity, the mensure of passivation activity, protection activity and induced activity.
H. the mensure to aphid cytotoxicity for the isothiazole oxime ether derivatives of the present invention：
The isothiazole oxime ether derivatives III of the present invention is determined as follows to aphid cytotoxicity：Using infusion process, Semen Viciae fabae
Aphid, its Latin is entitled：Aphis laburni Kaltenbach (ALK), the normal population of indoor feeding；Weigh test compound
2.5 milligrams in beaker, 1 DMF of Deca, i.e. DMF, plus 5 milliliters of acetone vibration dissolving samples, add
The water having Tween 80 is configured to the solution to be measured of 200 mcg/ml；By with least 60 black bean aphids for examination bean plant from
Cut in basin, impregnate 5 seconds in each medicinal liquid to be measured, take out and gently get rid of unnecessary medicinal liquid, be inserted in by water saturated sea
Moisturizing on silk floss, with, on bell glass cover, the opening of bell glass upper end with gauze sealing in case aphid escapes, put by raising after medicinal liquid is done
Aphid death state is checked, standard is after putting 48 hours：Can be creeped with test worm or can stand or six Tiao Tuineng strenuous exercises equal
For the worm that lives；With clear water for comparison, imidacloprid is positive control, calculates corrected mortality.
The invention has the beneficial effects as follows：Isothiazole oxime ether derivatives III has carried out guide's optimization, and the new chemical combination to synthesis
Thing has carried out the screening of insecticidal activity and bacteriostatic activity and antiviral activity.
The present invention is by specific preparation and biological activity determination embodiment more specific explanation isothiazole oxime ether derivatives III
Synthesis and biological activity and application, described embodiment is only used for illustrating the present invention and the unrestricted present invention, especially raw
Thing activity is merely illustrative of, and unrestricted this patent, and specific embodiment is as follows：
Embodiment 1
Change the preparation method of house thing II：
Add 1.12 mMs of compound I in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of ethanol, add
2.24 mMs of oxammonium hydrochloride .s, 0.11 gram of Deca triethylamine in final reaction system, that is, 1.12 mMs, it is stirred at room temperature 1 hour,
Removal of solvent under reduced pressure after reaction completely, with 10 milliliters of second mound ethyl ester dilution, adds 10 milliliters of water, isolates organic layer,
Twice of aqueous layer with ethyl acetate back extraction, house organic layer, organic layer saturated sodium-chloride is washed one time, and anhydrous sodium sulfate drying is taken out
Filter, removal of solvent under reduced pressure, residue is prayed purification through 200～300 mesh silica gel column layers and is obtained compound II, and eluant is Celsius for 60～90
The petroleum ether of degree: ethyl acetate, according to the difference of midbody product, volume ratio is 9: 1-2: 1, yield 80-95%；Work as R1For first
During base, nuclear magnetic data is as follows：1HNMR(CDCl3) δ 2.43 (s, 3H), 1.64 (s, 1H).
Embodiment 2
Change the preparation method one of house thing III：
Add 1.02 mMs of compound II in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of acetonitriles, to reaction
Middle add 0.21 gram, i.e. 1.53 mMs of potassium carbonate, add 1.53 mMs of R in the most backward reaction system2- X, is stirred at room temperature
Overnight, reactant liquor is concentrated after terminating by reaction, 10 milliliters of diluted ethyl acetate of residue, and the water of 10 milliliters of addition is by solid
All dissolve, isolate organic layer, aqueous layer with ethyl acetate back extraction one time, merge organic layer, organic layer saturated sodium-chloride is washed
One time, anhydrous sodium sulfate drying, sucking filtration, removal of solvent under reduced pressure, residue is leant on layer through 200～300 mesh silica gel and is prayed purification and obtains chemical combination
Thing III, eluant is 60～90 degrees Celsius of petroleum ether: ethyl acetate, and according to the difference of product, volume ratio is 20: 1 to 8: 1,
Yield 25-85%；Work as R2During for 2-butyne -1- base, nuclear magnetic data is as follows：1HNMR(CDCl3) δ 4.69 (q, J=2.3Hz, 2H),
2.31 (s, 3H), 1.81 (t, J=2.4Hz, 3H).
Embodiment 3
The preparation method two of compound III：
Add 2.36 mMs of compound II in 25 milliliters of single necked round bottom flask, with 5 milliliters of DMFs
Dissolving, adds 1.15 grams in reaction, i.e. 3.54 mMs of cesium carbonates add 3.54 mMs in the most backward reaction system
R2- X, is stirred at room temperature 2 hours, after reaction terminates, adds 10 milliliters of water in reactant liquor, is extracted with ethyl acetate, isolates
Organic layer, twice of aqueous layer with ethyl acetate back extraction, merge organic layer, organic layer saturated sodium-chloride washes one time, anhydrous sodium sulfate
It is dried, sucking filtration, removal of solvent under reduced pressure, residue obtains white solid through 200～300 mesh silica gel column chromatography purification, and eluant is
60～90 degrees Celsius of petroleum ether: ethyl acetate, volume ratio is 20: 1, yield 23%；Work as R1For amino, R2For 2-butyne -1- base
When, nuclear magnetic data is as follows：1HNMR(CDCl3) δ 5.23 (br, 2H), 4.58 (s, 2H), 1.81 (s, 3H)
Embodiment 4
The preparation method three of compound III：
Add 1.03 mMs of compound II in 50 milliliters of single necked round bottom flask, the dichloromethane with 25 milliliters of dryings is molten
Solution, then to 0.13 gram of Deca triethylamine in reaction system, that is, 1.24 mMs, ice bath stirs 15 minutes, under ice bath stirring
In backward reaction system, Deca is dissolved in 1.24 mMs in 10 milliliters of dry methylene chloride of compound R2- X, was stirred at room temperature
At night, reactant liquor is concentrated after terminating by reaction, and residue from dichloromethane dissolves, and organic layer uses saturated sodium bicarbonate, saturation successively
Saline solution is respectively washed one time, anhydrous sodium sulfate drying, sucking filtration, and rotary evaporation removes solvent, and residue is through 200～300 mesh silicagel columns
Chromatography purification obtains white solid, eluting punishment is 60～90 degrees Celsius of petroleum ether: ethyl acetate, and volume ratio is 20: 1, yield
60-70%；Work as R1For hydrogen, R2For 2- TRIFLUOROMETHYLBENZOYL, when X is chlorine, nuclear magnetic data is as follows：1HNMR(CDCl3)δ7.88
(s, 1H), 7.73 (s, 1H), 7.59 (s, 2H).
Embodiment 5
The preparation method four of compound III：
Add 0.55 mM of compound I in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of ethanol, then to reaction
1.10 mMs of NH of middle addition2OR2HCl, 0.11 gram of Deca triethylamine in final reaction system, that is, 1.10 mMs, room temperature is stirred
Mix 1 hour, removal of solvent under reduced pressure after reaction completely, with 10 milliliters of diluted ethyl acetate, add 10 milliliters of water, isolated
Machine layer, aqueous layer with ethyl acetate back extraction one time, merge organic layer, organic layer saturated sodium-chloride washes one time, anhydrous sodium sulfate is done
Dry, sucking filtration, removal of solvent under reduced pressure, residue obtains compound III through 200～300 mesh silica gel column chromatography purification, eluant be 60～
90 degrees Celsius of petroleum ether: ethyl acetate, according to the difference of product, volume ratio is 20: 1 to 9: 1, yield 60-95%；Work as R1For
Hydrogen, R2During for ethyl, nuclear magnetic data is as follows：1H NMR(CDCl3) δ 7.86 (s, 1H), 4.50 (q, J=7.1Hz, 2H), 1.46
(t, J=7.1Hz, 3H).
Embodiment 6
The Antibacterial Activity result of the isothiazole oxime ether derivatives of the present invention：
The title of frequently seen plants pathogenic fungi of present invention test and code name are as follows：AS：Tomato early blight bacterium, its latin name
For：Alternaria soldni、BC：Botrytis cinerea pers, its Latin is entitled：Botrytis cinerea、CA：Semen arachidis hypogaeae brown patch
Pathogenic bacteria, its Latin is entitled：Cercospora arachidicola、GZ：Fusarium graminearum, its Latin is entitled：Gibberella
zeae、PI：Phytophthora infestans, its Latin is entitled：Phytophthora infestans(Mont.)de Bary、PP：Herba Marsileae Quadrifoliae
Fruit Target spot pathogen, its Latin is entitled：Physalosporapiricola、PS：Rhizoctonia solani Kuhn, its Latin is entitled：
Pellicularia sasakii、RC：Rhizoctonia cerealis, its Latin is entitled：Rhizoctonia cerealis、SS：Sclerotina Sclerotiorum in Winter Rape
Core pathogenic bacteria, its Latin is entitled：Sclerotinia sclerotiorum, these strains have good representativeness, can represent
The kind of most of pathogen that field occurs in agricultural production.Thalli growth rate method measurement result is shown in Table 2, and table 2 shows, 50
During mcg/ml, all compounds of present invention synthesis all have different degrees of bactericidal activity.Compound CL01-36B, CL02-
02nd, CL02-03, CL02-06, CL02-43 to the inhibitory activity of tomato early blight bacterium more than 50%, wherein compound CL01-
48th, the inhibitory activity of CL02-11, CL02-16 nearly 70%, the inhibitory activity of especially compound CL01-35, CL01-36A reaches
90%, it is significantly higher than comparison medicament Fluoxastrobin.The Activity Results of Semen arachidis hypogaeae Cercospora asparagagas are shown, compound CL01-48, CL02-06,
The activity of CL02-11 is higher than 55%, and the inhibitory activity of wherein compound CL01-35 reaches 82%, is significantly higher than the phonetic bacterium of comparison medicament
The activity of ester, wherein CL01-36A is optimal, reaches 100%.The active testing result of fusarium graminearum is shown, compound
More than 80%, the activity of wherein compound CL01-36A, CL02-06 reaches 100% to the activity of CL01-35, CL01-48, activity
It is significantly higher than comparison medicament Fluoxastrobin.The Activity Results of Botryosphaeria berengeriana f. sp are shown, compound CL01-35, CL02-02,
More than 95%, the activity of wherein compound CL01-36A, CL01-48, CL02-16 reaches the suppression ratio of CL02-34
100%.The active testing of botrytis cinerea pers is shown, the activity of compound CL01-35, CL02-02 more than 80%, wherein
The activity of compound CL01-36A, CL01-34 has exceeded 90%, higher than comparison medicament Fluoxastrobin.Work to Sclerotinia sclerotiorum
Property test show, the activity of compound CL01-36A, as comparison medicament Fluoxastrobin, reaches 100%.Work to Rhizoctonia cerealis
Property test display, the activity of compound CL01-35, CL01-36A, CL01-48, CL02-02 is above comparison medicament Fluoxastrobin,
Exceed 88%, the activity of especially compound CL02-34 reaches 100%.The active testing of Rhizoctonia solani Kuhn is shown, chemical combination
Thing CL01-35, the activity of CL01-36B, CL02-11 more than 80%, wherein compound CL01-36A, CL01-48, CL02-16
Activity optimal, reach 100%, activity is significantly higher than comparison medicament Fluoxastrobin.The active testing of Ma Lingzhu late disease bacteria is shown,
The activity of compound CL01-35, CL01-36A reaches 100%, is significantly higher than comparison medicament Fluoxastrobin.Above-claimed cpd from synthesis
Bactericidal activity can be seen that the bactericidal activity that compound CL01-35, CL01-36A have wide spectrum, except compound CL01-35
90% is less than to peanut Cercospora bacteria inhibitory activity, compound CL01-35, CL01-36A all exist to other bacterium inhibitory activity
More than 90%.
Embodiment 7
The insecticidal activity of the isothiazole oxime ether derivatives of the present invention：
Insecticidal activity assay the results are shown in Table 3, and table 3 is visible：When reagent agent concentration is 100 mg/litre, observation effect 72
After hour, compound is weaker to the toxic action of black bean aphid, and part of compounds is even without toxic action.
Embodiment 8
The anti-TMV activity of the isothiazole oxime ether derivatives of the present invention：
The measurement result of TMV activity is shown in Table 4, and table 4 shows, the majority of compounds of the present invention has preferably anti-TMV's
Activity；In 100 mcg/ml, all compounds of present invention synthesis all have different degrees of anti-TMV activity.In treatment mould
Under formula, the suppression ratio of compound CL01-36A, CL02-03, CL02-33, CL02-34 is higher than 75%, higher than comparison medicament Ningnan
Mycin.Under passivation pattern, compound CL01-36A, CL01-36B, CL01-43, CL01-48, CL02-02, CL02-06,
The suppression ratio of CL02-09, CL02-11, CL02-16, CL02-37 is higher than 80%, higher than comparison medicament virazole, wherein, changes house
The suppression ratio of thing lfy005-34 and lfy006-27 is higher than 70%.Under induction pattern, compound CL01-35, CL01-36A,
The suppression ratio of CL01-43, CL02-03, CL02-36 is all more than 50%.It can be seen that, the majority of compounds of the present invention has very well
Anti- TMV activity.
Embodiment 9
The isothiazole oxime ether derivatives of the present invention and agriculturally acceptable auxiliary agent and following one or more commodity parasite killing
Agent group is combined in the purposes preparing in compounded pesticides：
Described commodity insecticide is selected from：Chlopyrifos, sub- Nong, Acetamiprid, Affirm (Merck Co.), milbemectin, AVM hereinafter
Rhzomorph, pleocidin, fenvalerate, esfenvalerate, cypermethrin, effective cypermethrin, Grenade (ICI)., bromine cyanogen chrysanthemum
Ester, Fenpropathrin, Beta- cyfloxylate, cyfloxylate, Lambda- Grenade (ICI)., Permanone, benzyl chloride
Chrysanthemum ester, allethrin, cyhalothrin, Biphenthrin, Permethrin, ethofenprox, flumethrin, fluvalinate, pyrrole worm
Quinoline, Acetamiprid, Nitenpyram, imidaclothiz, thiacloprid, Diacloden, clothianidin, MTI-446, clothianadin, Da Tenan, diflubenzuron, go out
Young urea, Teflubenzuron, deinsectization are grand, HEXAFLUMURON, Cascade, pyridine worm are grand, lufenuron, poisonous insect urea, penfluron, Noviflumuron are many
Fluorine urea, its CAS 121451-02-3, flucycloxuron, Novaluron are Novaluron, chlorfluazuron, Bay sir 6874 i.e. { 1-
[(3.5- bis- chloro- 4) 4-nitrophenoxy phenyl 3-3- (2- chlorobenzene)-urea }, Bay SIR-8514 be [1- (4- trifluoromethoxy
Phenyl) -3- (2- chlorobenzene)-urea], piperazine worm urea, Bistrifluron be bistrifluron, furan tebufenozide, tebufenozide, chlorine worm acyl
Hydrazine, methoxyfenozide, ring tebufenozide, Rogor, omethoate, dichlorvos, orthene, triazophos, quintiofoss, pyridazine sulfur
Phosphorus, isazofos, isoprocarb, sevin, Aphox, meta-tolyl-N-methylcarbamate (MTMC), Mobucin, cartap, Bassa, leaf disperse, carbaryl, rosickyite
Carbofuran, carbosulfan, cartap, fenisobromolate, Hexythiazox, fenpyroximate, pyridaben, clofentezine, propargite, diafenthiuron, third
Carbosulfan, pymetrozine, Envidor, spiral shell worm ester, spiral shell worm ethyl ester, butene-fipronil, azacyclotin, Buprofezin, phonamiphoss, fluorine worm
Nitrile, Cupric sulfate, dimehypo, chlorantraniliprole, Flubendiamide, fluorine cyanogen insect amide, cyanogen insect amide, Tolfenpyrad, tebufenpyrad, bromine worm
Nitrile, pyrazinones, etoxazole, tebufenpyrad, rattle away young ketone, Nylar, emaricin；The isothiazole oxime ether derivatives of the present invention are in gained
Total weight/mass percentage composition in compounded pesticides is 1%-90%, and the isothiazole oxime ether derivatives of the present invention and described commodity kill
The ratio of worm agent is mass percent 1%: 99% to 99%: 1%；The dosage form that described compounded pesticides are suitable for is selected from seed treatment
Emulsion, aqueous emulsion, big granule, microemulsion, suspension emulsion, water-soluble granule, soluble thick agent, water-dispersible granules, poison grain, aerosol
Agent, block poison bait, sustained-release block, dense poison bait, CG/Encapsulated granule, micro-capsule suspension, Waterless Seed Dressing powder, cream, electrostatic spray agent, oil
Bag aqueous emulsion, oil in water emulsion, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog rod, seed treatment suspending agent, smog piece,
Smog ball, granular poison bait, foaming agent, drift powder, ointment, thermal fog, solid-liquid mixing dress agent, liquid liquid mixing dress agent, harl
Gu agent, solid/mixing fill agent, medicine paint, microgranule, oil suspending agent, oil-dispersing property powder, lamellar poison bait, dense colloid, sprinkle and pour agent, plant clothing
Agent, liniment, fritter poison bait, suspended emulsion, film forming oil preparation, soluble powder, seed treatment water solube powder, ultra-low volume are hanged
Floating agent, follow the trail of powder, ultra low volume liquids, steam releasing agent, any one in wet-mixing kind water-dispersible powder；Described compounding
The plant that insecticide is suitable for is selected from Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, Herba bromi japonici, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Ma Lingzhu, Maninot esculenta crantz., Semen sojae atricolor, Holland
Bean, Semen Viciae fabae, Semen Pisi sativi, Semen phaseoli radiati, Semen Phaseoli, Cotton Gossypii, silkworm and mulberry, Semen arachidis hypogaeae, Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, Caulis Sacchari sinensis, coffee, cocoa, people
Ginseng, Bulbus Fritillariae Uninbracteatae, rubber, Cortex cocois radiciss, Elaeis guineensis Jacq., Folium Agaves Sisalanae, Nicotiana tabacum L., Fructus Lycopersici esculenti, Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis, hot pickled mustard tube, Radix Betae, Brassica campestris L,
Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo, hami melon, Fructus Chaenomeliss, Fructus Mali pumilae, mandarin orange, peach tree, tea, wild vegetable, bamboo sprout, Flos lupuli (Flos Humuli Lupuli), Fructus Piperiss, Fructus Musae,
Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；The insect pest of described compounded pesticides preventing and treating is selected from Locusta migratoria manilensis (Meyen), reading room management, Chinese rice grasshopper, Japan
Yellow ridge locust, single thorn Gryllotalpa, Oriental burmeister, rice thripses, onion thrips, greenhouse thrips, haplothrips aculeatus, Mai Jian pipe thrips, greenhouse white lead
Louse, Bemisia tabaci, rice green leafhopper, green leaf hopper, chlorita biguttula, speckle clothing plant hopper, brown paddy plant hopper, white backed planthopper, small brown rice planthopper, the flat angle of Caulis Sacchari sinensis fly
Louse, cotten aphid, green bugs, grain aphid, black peach aphid, kaoliang aphid, radish aphid, icerya purchasi, Pseudaulacaspis pentagona, unaspis shield kuwana, san jose scale, white
Wax insect, ceroplastes rubens, Didesmococcus koreanus Borchs, pear lace bug, Fructus Musae lace bug, thin corner piece stinkbug, Orius minutus, slender rice bug, paddy fly, rice are brown
Stinkbug, scotinophora lurida, Nezara viridula smaragdula Fabricius., green plant bug, alfalfa plant bug, black striped plant bug, chrysopa septempunctata, beautiful Herba Marsileae Quadrifoliae sandfly, Chinese green lacewing, rain moth, casemaking clothes moth, Huang
Limacodidae, brown Limacodidae, thosea siensis, gelechiid, pink bollworm, sweet work gelechiid, diamondback moth, small heart-eating peach worm, eating-core bean worm, the little food of Fructus Persicae
Heart worm, Fructus Mali pumilae Spilonota lechriaspis, brown belt length leaf roller, Adoxophyes cyrtosema, striped rice borer, bean-pod borer, Pyrausta nubilalis (Hubern)., yellow rice borer, dish
Snout moth's larva, rice leaf roller, bar snout moth's larva, Notarchaderogata, dichocrocis punctiferalis, armyworm, Prodenia litura, rice green caterpillar, anomis flava, Radix Betae night
Moth, pink rice borer, bollworm, ancient cooking vessel point diamond, black cutworm, big cutworm, yellow cutworm, steal acute tonsillitis, gypsymoth, palaearctic sweet potato,
The yellow a kind of butterfly harmful to crop plants of greenish brown hawk moth, straight burr rice hesperiidae, pelopidas mathias, Papilio xuthus, Common Mormon, cabbage butterfly, pyrameis indica, Boehmeria,
Bean brassica rapa, Venus ground beetle, wrinkle sheath ground beetle, wheat head ground beetle, pleonomus canaliculatus, Agriotes subrittatus Motschulsky, khapra beetle, attagenus piceus, Citrus are little
Buprestid beetle, golden edge buprestid beetle, tenebrio molitor, dark mealworm, red flour beetle, confused flour beetle, Aerugo different beetle, H. parallela, North China
Holotrichia oblita, mulberry borer, longicorn beetle, nadezhdiella cantori, pink neck Anoplophorae seu Aprionae, big daikon leaf beetle, daicon leaf beetle, aulacophora femoralises, yellow knee
Flea beetle, Callosobruchus chinensises, pea weevil, broad bean weevil, sitophilus zea-maises, rice weevil, dolerus tritici, pear fruit sawfly, fulminant leucorrhagia with yellowish discharge ichneumon wasp, armyworm white star ichneumon wasp,
Corn earworm hangs cocoon ichneumon wasp, Campoletis chlorideae, snout moth's larva stain wart ichneumon wasp, mosquito, fly, horsefly, wheat midge, contarinia tritici, rice wart
Mosquito, citrus fruit fly, melonfly, the latent fly of wheat leaf ash, Americal rice leaf miner, Soybean stem borer, frit fly, Hylemyia Platura Meigen, onion fly, Radix Raphani fly,
Full skirt Exorista civilis, Pyrausta nubilalis (Hubern). are strict to post fly, armyworm.
Embodiment 10
In the isothiazole oxime ether derivatives of the present invention and agriculturally acceptable auxiliary agent and following commodity antibacterial
Any one or more group is combined in the purposes preparing in composite bactericide：
Described commodity antibacterial lures amine, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- selected from diazosulfide, tiadinil, first thiophene
Formic acid, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- sodium formates, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- Ethyl formates, 4- bromomethyl -1,
2,3- thiadiazoles -5- Ethyl formates, 4- iodomethyl -1,2,3- thiadiazoles -5- Ethyl formates, 4- bromomethyl -5- methyl isophthalic acid, 2,3-
Thiadiazoles, 4- iodomethyl -5- methyl isophthalic acid, 2,3- thiadiazoles, 4,4- dibromo methyl isophthalic acid, 2,3- thiadiazoles -5- Ethyl formates, 3,4-
Two chloroisothiazole -5- formic acid, 3,4- bis- chloroisothiazole -5- sodium formate, 3,4- bis- chloroisothiazole -5- Ethyl formate, DL- beta-amino
Butanoic acid, isotianil, virazole, antofine, Ningnanmycin, first thiophene lure amine, salicylic acid, cytosintetidemycin, dichloro-isonicotinic acid, allyl
Isothiazole, cymoxanil, thiram, ziram, Mancozeb, AL-PHOSETHYL aluminum tris(ethyl phosphite), thiophanate-methyl, Bravo, enemy can pine, procymidone,
Fenpropidin, thiophanate methyl, thiophanate, Metalaxyl-M, salicylic acid, flumorph, dimethomorph, mefenoxam, efficient benzene frost
Spirit, double chlorine zarilamid, flusulfamide, first flusulfamide, thiophene fluorine bacterium amine, flutolanil, tecloftalam, ring propionyl bacterium amine, cyflufenamid, ring acyl
Bacterium amine, zarilamid, Silthiopham, furametpyr, pyrrole metsulfovax, mandipropamid, zoxamide, fenfuram, carboxin, second
Bacterium profit, RP-26019, Fluoxastrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, SSF 126, orysastrobin, ZEN 90160, azoles bacterium amine
Ester, trifloxystrobin, Enestroburin, alkene oxime amine, oxygen ring azoles, bromuconazole, SAN-619F, Difenoconazole, olefin conversion, efficient alkene azoles
Alcohol, epoxiconazole, RH-7592, Fluquinconazole, bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-ylmethyl)silane, Flutriafol, hexaconazole, glyoxalin, kind bacterium azoles, metconazole, nitrile bacterium azoles, penta bacterium
Azoles, propiconazole, prothioconazoles, simeconazoles, Tebuconazole, tetraconazole, Triadimenol, triticonazole, bitertanol, probenazole, wheat
Fringe is peaceful, imazalil, efficient imazalil, Prochloraz, fluorine bacterium azoles, cyazofamid, Fenamidone, imidazoles, pefurazoate, cycloheximide triazole,
Pyridine bacterium azoles, mould spirit, white spirit, Guardian, Grandox fumigant, octhilinone, benthiozole, dodemorph, butadiene morpholine, ten
Morpholine, fenpiclonil, CGA-173506, fluazinam, pyrifenox, ring pyridine bacterium amine, Boscalid, fluopicolide, pyridine bacterium amine, phonetic collarium
Amine, fluorine mepanipyrim, ferimzone, mepanipyrim, pyrimethanil, Fenarimol, nuarimol, chinomethionat, dithianon, ethoxy quinoline
Quinoline, hydroxyquinoline, the third oxygen quinoline, quinoxyfen, diethofencarb, iprovalicarb, benzene metsulfovax, Propamocarb, methasulfocarb, edifenphoses,
Iprobenfos, pyrazophos, tolelofos-methyl, blasticidin-Ss, kasugarnycin, polyoxin, Polyoxin, valida, well ridge are mould
Element, streptomycin, metalaxyl, furalaxyl, M 9834, ofurace, mebenil, carbendazim, benomyl, thiophanate-methyl, triazolone,
Bupirimate, dimethirimol, ethirimol, difoltan, captan, folpet, vinclozolin, fluoromide, sclerotium
Only, Isoprothiolane, kitazine, Yekuzuo, pentachloronitrobenzene, Mancozeb, Propineb, phosethyl-Al, sulfur, Bordeaux mixture,
Copper sulfate, copper oxychloride, Red copper oxide, Copper hydrate, metrafenone, Pencycuron, diclomezin, Rabcide, pyroquilon, volution bacterium
Amine, tricyclazole, triforine, the pyridine of many fruits, the pungent salt of biguanide, iminoctadine, botran, benzene flusulfamide, toluene flusulfamide, indocate,
Fenaminosulf, oxolinic acide, probenazole, bronopol, iodomethane, metham-sodium, enemy line ester, dazomet, nemamort, lythidathion,
Cadusafos, O,O-diethyl O-[p-(methylsulfinyl)phenyl, thionazin, fenamiphos, phonamiphoss, O-2,4-dichlorophenyl O,O-diethyl phosphorothioate, isazofos, fosthietan, oxamyl, Aldicarb, grams hundred
Prestige, vikane, dichloropropylene, dichloro-isonicotinic acid, allyl isothiazole；The isothiazole oxime ether derivatives of the present invention compound in gained and kill
Total weight/mass percentage composition in microbial inoculum is 1%-90%, the isothiazole oxime ether derivatives of the present invention and described commodity antibacterial
Ratio is mass percent 1%: 99% to 99%: 1%；The dosage form that described composite bactericide is suitable for is selected from appointing in following dosage forms
Meaning is a kind of：Wettable powder, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment Emulsion, water
Emulsion, big granule, microemulsion, oil-suspending agent, the seed with coated pesticidal, water-soluble granule, soluble thick agent, water dispersible grain
Agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, CG/Encapsulated granule, Waterless Seed Dressing powder, cream, electrostatic spray agent, oil
Bag aqueous emulsion, oil in water emulsion, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog rod, seed treatment suspending agent, smog piece,
Smog ball, granular poison bait, foaming agent, drift powder, ointment, thermal fog, solid-liquid mixing dress agent, liquid liquid mixing dress agent, harl
Gu agent, solid/mixing fill agent, medicine paint, seed treatment liquor, microgranule, oil-dispersing property powder, lamellar poison bait, dense colloid, sprinkle and pour
Agent, liniment, suspended emulsion, film forming oil preparation, soluble powder, seed treatment water solube powder, ultra-low volume suspending agent, tracking
Powder, ultra low volume liquids, steam releasing agent, wet-mixing kind water-dispersible powder；The plant that described composite bactericide is suitable for is selected from
Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, Herba bromi japonici, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Rhizoma Solani tuber osi, Maninot esculenta crantz., Semen sojae atricolor, garden pea, Semen Viciae fabae, Semen Pisi sativi, Semen phaseoli radiati, little
Bean, Cotton Gossypii, silkworm and mulberry, Semen arachidis hypogaeae, Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, Caulis Sacchari sinensis, coffee, cocoa, Radix Ginseng, Bulbus Fritillariae Uninbracteatae, rubber, Cortex cocois radiciss, oil
Palm fibre, Folium Agaves Sisalanae, Nicotiana tabacum L., Fructus Lycopersici esculenti, Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis, hot pickled mustard tube, Radix Betae, Brassica campestris L, Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo, Kazakhstan
Close melon, Fructus Chaenomeliss, Fructus Mali pumilae, mandarin orange, peach tree, tea, wild vegetable, bamboo sprout, Flos lupuli (Flos Humuli Lupuli), Fructus Piperiss, Fructus Musae, Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；Institute
State the applicable controlling disease of composite bactericide to be selected from：Wheat rust, wheat scab, wheat powdery mildew, wheat virus disease, Semen Tritici aestivi
Avenge mould leaf blight, Semen Tritici aestivi compacted spore leaf spot, flag smut of wheat, take-all, wheat sharp eyespot, Semen Tritici aestivi downy mildew, Rhizoma Solani tuber osi
Late blight, wart of potatoes, potato scab, target, bacterial ring rot o potato, potato bacterial wilt, Ma Ling
Potato balck shank, Potyviruses and viroid disease, Ma Lingzhu soft rot, dry rot of potato, Rhizoma Solani tuber osi verticillium wilt, Rhizoma Solani tuber osi
Tar spot, Ma Lingzhu bacterial wilt, Ma Lingzhu ring rot, Ma Lingzhu balck shank, bacterial soft rot of potato, cotton wilt, cotton yellow
Wither disease, angular leaf spot of cotton, red leaf blight, cotton seedling blight, Cotton Gossypii damping off, cotton anthracnose, cotton spoting verticillium wilt, cotton charcoal
Cellulitis disease, cotton spoting verticillium wilt, rice blast, rice sheath blight disease, water rice brown spot, small round sclerotial disease of rice, Oryza sativa L. are disliked
Seedling diseases, downymildewofrice, rice green smut, rice leaf sheath rot, bacterial blight of rice, bacterial leaf streak of rice, Oryza sativa L.
Bacterial Footrot, stripe disease, black streaked dwarf virus of rice, Oryza sativa L. rice black sclerotium stalk rot, the leaf blight of corn, jade
Rice helminthosporium maydis, Helminthosporium carbonum, maize brown spot, maize sheath blight, corn rust, maize head smut, Corn Stalk Rot, jade
Rice smut, Semen Maydiss dry rot, maize virus disease and corn stalk rot disease, sclerotinia rot of colza, Rape virus disease, oilseed rape downy mildew,
White rust of colza, root rot, soybean sclerotinia crown rot, grey speck of soybean, soybean Mosaic, soy bean cyst roundworm, Semen sojae atricolor
Root-knot nematode, soybean rust, soybean anthracnose, bacterial pustule of soybean, Semen sojae atricolor spot blight, downy mildew, Semen arachidis hypogaeae green grass or young crops are withered
Disease, Diplodia gossypina, Semen arachidis hypogaeae root rot, the cercospora brown spot of peanut, Peanut Web Blotch Disease, activity of peanuts disease, Peanut Scab, Nicotiana tabacum L. green grass or young crops are withered
Disease, wildfire, Nicotiana tabacum L. hollw stalk, Tobacco Angular Leaf Spot Disease, black shank, Alternaria alternate, frog-eye leaf spot of tobacco, Nicotiana tabacum L. anthrax
Disease, black root of tobacco, fusarium tabacinum root rot, Tobacco seedling diseases, Nicotiana tabacum L. damping-off, Nicotiana tabacum L. junk leaf spot, Nicotiana tabacum L. are white
Powder disease, Nicotiana tabacum L. southern blight, Nicotiana tabacum L. melasma, tobacco mosaic disease, cucumber mosaic virus, etch virus of tobacco, Chinese cabbage downy mildew, Chinese cabbage are soft
Maize ear rot, Chinese cabbage Tipburn Disease, Chinese cabbage virosiss, Cabbage Leaf Spot, Seed detection, Chinese cabbage anthrax, cabbage clubroot, Fructus Lycopersici esculenti
Bacterial speck, tomato late blight, Fructus Lycopersici esculenti blossom-end rot, Fructus Lycopersici esculenti powdery mildew, Fructus Lycopersici esculenti damping off, Fructus Lycopersici esculenti Flos Pelargonii mosaic disease, kind
Eggplant bacterial speck, tomato yellow leaf curl virus, leaf muld of tomato, tomato virus disease, tomato late blight, Fructus Lycopersici esculenti damping off with
Damping-off, Fructus Lycopersici esculenti deformation fruit, Fructus Lycopersici esculenti perforation fruit, tomato black ring virus disease, Fructus Lycopersici esculenti rot stem nematodes disease, tamato fruit buphthalmos disease,
Fructus Lycopersici esculenti stain root rot, Fructus Lycopersici esculenti stain root rot, Fructus Lycopersici esculenti branch spore fruit rot, Fructus Lycopersici esculenti heartrot, Fructus Lycopersici esculenti Rhizopus fruit rot, Fructus Lycopersici esculenti are low
Warm obstacle, Fructus Lycopersici esculenti bolter, Fructus Lycopersici esculenti physiological leaf curl, Fructus Lycopersici esculenti damping off, Fructus Lycopersici esculenti fruit drop disease, Fructus Lycopersici esculenti bud blight, kind
Eggplant soft rot, Fructus Lycopersici esculenti stem rot, tomato seedling damping-off, Fructus Lycopersici esculenti sun burn, Fructus Lycopersici esculenti shot hole, Fructus Lycopersici esculenti Hydrargyri Oxydum Rubrum disease, tomato virus disease, kind
Eggplant cracked fruit, canker of tomato, Fructus Lycopersici esculenti umbilicuss corruption fruit, Fructus Lycopersici esculenti Semen Sesami pinta bacterium, bacterial spot of tomato, Fructus Lycopersici esculenti rot leaf poison
Disease, tomato yellow leaf curl virus disease, Fructus Solani melongenae cotton disease, Fructus Solani melongenae sclerotiniose, Fructus Solani melongenae bacterial wilt, Fructus Solani melongenae Phomopisis vexans, eggplant verticillium wilt,
Fructus Solani melongenae leaf spot, Fructus Solani melongenae early blight, Fructus Solani melongenae virosiss, Fructus Solani melongenae leaf spot disease, Fructus Solani melongenae leaf mold, Fructus Solani melongenae powdery mildew, Fructus Solani melongenae spot disease,
Fructus Solani melongenae coal spot disease, cercospora leaf spot of egg plant, helminthosporium leaf blight and fruit rot of egg plant, Fructus Solani melongenae epidemic disease, eggplant anthracnose, Fructus Solani melongenae rhizopus soft rot, Fructus Solani melongenae
Droop, grey mould of egg plant, Fructus Solani melongenae base rot disease, Fructus Capsici Capsicum annuum L. virosiss, Fructus Capsici early blight, Fructus Capsici leukoderma, Fructus Capsici white star
Disease, Fructus Capsici leaf spot, Fructus Capsici Scald, Fructus Capsici sooty mold, capsicum wilt, Fructus Capsici sclerotiniose, Fructus Capsici sunscald, Fructus Capsici virus
Disease, Fructus Capsici malformed fruit, Fructus Capsici blossom-end rot, Fructus Capsici soft rot, bacterial spot of pepper, Fructus Capsici bar virus scab, Fructus Capsici pythium rot, Fructus Capsici
Black pointss, Fructus Capsici spot blight, Fructus Capsici melasma, Fructus Capsici verticillium wilt, pepper bacterial leaf spot, Fructus Capsici brown rot, Fructus Capsici root-rot
Disease, Fructus Capsici damping-off, pepper anthracnose, Fructus Capsici brown spot, Fructus Capsici downy mildew, Botrytis cinerea, Fructus Capsici leaf blight, Fructus Capsici leaf mold
Disease, Fructus Capsici damping off, capsicum epidemic disease, downy mildew of garpe, uncinula necator, brown spot of grape, grapevine leafroll disease, Grapevine Fan Leaf Virus
Disease, Fructus Vitis viniferae rust, Fructus Vitis viniferae ring spot, Fructus Vitis viniferae leaf spot, the little brown spot of Fructus Vitis viniferae, Fructus Vitis viniferae zonate spot, Fructus Vitis viniferae graywall, Fructus Vitis viniferae young sprout
The golden yellow disease of wasting disease, Fructus Vitis viniferae mosaic disease, Fructus Vitis viniferae wasting disease, Fructus Vitis viniferae stripe disease, Fructus Vitis viniferae, Fructus Vitis viniferae infectivity necrosis disease, Fructus Vitis viniferae Huang point
Disease, Fructus Vitis viniferae lug disease, Fructus Vitis viniferae vein necrosis disease, Grapevine fleck virus disease, the starlike mosaic disease of Fructus Vitis viniferae, Fructus Vitis viniferae Pearls, Fructus Vitis viniferae
White rot, bitter rot or anthracnose of grape, Fructus Vitis viniferae room rot, grape grey mould, grapevine anthracnose, black rot of grape, Fructus Vitis viniferae big room rot, Portugal
Grape coal selects that disease, Fructus Vitis viniferae are brown to select disease, Fructus Vitis viniferae mould dirt disease, Fructus Vitis viniferae bitter rot, grape branch spore rot, Fructus Vitis viniferae penicilliosiss, iron link chain
Lattice spore canker, apple tree canker, dry rot of apple, ring rot of apple, Fructus Mali pumilae branch Peptic Ulcerss, Fructus Mali pumilae bleb Peptic Ulcerss, Herba Marsileae Quadrifoliae
Really red clothing disease, Fructus Mali pumilae die back disease, Fructus Mali pumilae branch-rot, apple anthracnose, Apple Mould Core, rust of apple (Gymnosporangium yamadai), Fructus Mali pumilae blossom rot, Fructus Mali pumilae
Brown rot, black fruit rot of apple, Fructus Mali pumilae phytophthora rot, Apple Sooty, sick apple marssonina leaf spot, alternaria leaf spot of apple, Fructus Mali pumilae wheel speckle
Disease, Fructus Mali pumilae graywall, apple mildew, scab of apple, silver leaf of apple, Fructus Mali pumilae invade seven property root rot, armillariella root rot of apple, Herba Marsileae Quadrifoliae
Fruit Root-rot disease, Fructus Mali pumilae southern blight, apple violet root rot, rosellinia trunk rot of apple, Apple crown gall, Fructus Mali pumilae decline disease, Fructus Mali pumilae rust fruit
Disease, apple mosaic, apple green wrinkle fruit disease, Fructus Mali pumilae fruit-shrink disease, Apple little leaf, apple chlorosis, Fructus Mali pumilae bitter pit, Fructus Mali pumilae water
Cardiopathia, apple superficial scald, carbuncle apple scab, Gold Delicious apple fruit russeting, green mold of apple, Fructus Mali pumilae soft rot, Apples meat powder
Continuous disease, apple pulp brown stain disease, Fructus Mali pumilae brown heart, pear scab, black rot of pear, Fungus of Pear Canker Disease, pears southern blight, pear tree wood are rotten
Disease, pears die back disease, rust of pear, Pear black spot, pears graywall, pears brown spot, pears Socty Blotch And Greasy Blotch, pears top rot, pears fruit-shrink disease, pears are yellow
Leaf disease, anthracnose of peach, Fructus Persicae reality maize ear rot, peach fruit maize ear rot, Fructus Persicae soft rot, Fructus Persicae Peptic Ulcerss, peach tree powdery mildew, peach brown rot, Fructus Persicae scab
Disease, the abnormal fruit disease of Fructus Persicae, peach tree sooty mould, peach tree leaf-curl, peach tree fungoids shothole disease, peach tree Bacterial septicaemia syndrome, peach tree tikka
Disease, peach tree leaf rust, peach tree mosaic disease, peach tree red-leaf disease, peach tree canker, peach gummosis, peach tree wood rot, peach tree dry up
Disease, Peach crown gall, peach tree root rot, peach tree root knot nematode disease, Citrus Huanglongbing pathogen, exocortis, the broken leaf disease of Citrus, Citrus
Decline disease, Satsuma dwarf virus, citrus bacterial canker disease, citrus scab, citrus anthracnose, Citrus foot rot, Citrus resin disease,
Citrus bleeding disease, Citrus fuliginous, Citrus powdery mildew, Citrus fat select maculopathy, Citrus plan fat selects maculopathy, the red clothing of Citrus is sick,
Citrus felt fungus, Citrus seedling blight, Citrus Seedling epidemic disease, banana bunchy top disease, Banana Mosaic Disease, Fructus Musae Fusarium spp. wither
Disease, Cercospora musae bacterium leaf spot, the Fructus Musae secretly mould leaf spot of double spore, the mould leaf spot of the little Dou Shi of Fructus Musae, banana freckle, Banana Leaf pestilence
Disease, banana anthracnose, banana crown rot, Caulis et Folium Brassicae capitatae bacterial black rot, cottony rot of cabbage, cabbage black rot, black spot of cabbage, sweet
Blue brown spot, Caulis et Folium Brassicae capitatae blastomere disease, Caulis et Folium Brassicae capitatae virosiss, Caulis et Folium Brassicae capitatae soft rot, Caulis et Folium Brassicae capitatae bolting disease, cabbage downy mildew, Caulis et Folium Brassicae capitatae anthrax in advance
Disease, black leg of cabbage, Caulis Sacchari sinensis pineapple disease, smut of sugarcane, sugarcane ratoon stunting disease, Caulis Sacchari sinensis brown streak, sugarcane rust, Sorghum vulgare Pers. are black
Fringe disease, Sorghum vulgare Pers. leaf spot, Sorghum vulgare Pers. anthrax, Sorghum vulgare Pers. leaf blight, Sorghum vulgare Pers. virosiss.
Embodiment 11
The isothiazole oxime ether derivatives of the present invention and agriculturally acceptable auxiliary agent and with following commodity antiviral agent in
Any one or more group be combined in the compounding anti-plant virus agent of preparation, the purposes in activating plants agent：
Described commodity antiviral agent is selected from：Diazosulfide, tiadinil, first thiophene lure amine, 4- methyl isophthalic acid, 2,3- thiophenes two
Azoles -5- formic acid, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- sodium formates, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- Ethyl formates, 4- bromine first
Base -1,2,3- thiadiazoles -5- Ethyl formates, 4- iodomethyl -1,2,3- thiadiazoles -5- Ethyl formates, 4- bromomethyl -5- methyl -
1,2,3- thiadiazoles, 4- iodomethyl -5- methyl isophthalic acid, 2,3- thiadiazoles, 4,4- dibromo methyl isophthalic acid, 2,3- thiadiazoles -5- formic acid second
Ester, 3,4- bis- chloroisothiazole -5- formic acid, 3,4- bis- chloroisothiazole -5- sodium formate, 3,4- bis- chloroisothiazole -5- Ethyl formate,
DL- beta-aminobutyric acid, virazole, antofine, Ningnanmycin, first thiophene lure amine, salicylic acid, cytosintetidemycin, dichloro-isonicotinic acid, allyl
Isothiazole, well ridge azanol, jingganmycin；The isothiazole oxime ether derivatives of the present invention compound anti-plant virus agent, plant in gained
Total weight/mass percentage composition in activator is 1%-90%, the isothiazole oxime ether derivatives of the present invention and described commodity antiviral
The ratio of agent is mass percent 1%: 99% to 99%: 1%；Described compounding anti-plant virus agent, the dosage form of activating plants agent
Selected from wettable powder, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment Emulsion, water and milk
Agent, big granule, microemulsion, oil-suspending agent, the seed with coated pesticidal, water-soluble granule, soluble thick agent, water dispersible grain
Agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, CG/Encapsulated granule, Waterless Seed Dressing powder, cream, electrostatic spray agent, oil
Bag aqueous emulsion, oil in water emulsion, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog rod, seed treatment suspending agent, smog piece,
Smog ball, granular poison bait, foaming agent, drift powder, ointment, thermal fog, solid-liquid mixing dress agent, liquid liquid mixing dress agent, harl
Gu agent, solid/mixing fill agent, medicine paint, seed treatment liquor, microgranule, oil-dispersing property powder, lamellar poison bait, dense colloid, sprinkle and pour
Agent, liniment, suspended emulsion, film forming oil preparation, soluble powder, seed treatment water solube powder, ultra-low volume suspending agent, tracking
Any one in powder, ultra low volume liquids, steam releasing agent, wet-mixing kind water-dispersible powder；Described compounding anti-phytopathy
Toxic agent, activating plants agent be suitable for plant be selected from Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, Herba bromi japonici, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Ma Lingzhu, Maninot esculenta crantz.,
Semen sojae atricolor, garden pea, Semen Viciae fabae, Semen Pisi sativi, Semen phaseoli radiati, Semen Phaseoli, Cotton Gossypii, silkworm and mulberry, Semen arachidis hypogaeae, Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, Caulis Sacchari sinensis, coffee
Coffee, cocoa, Radix Ginseng, Bulbus Fritillariae Uninbracteatae, rubber, Cortex cocois radiciss, Elaeis guineensis Jacq., Folium Agaves Sisalanae, Nicotiana tabacum L., Fructus Lycopersici esculenti, Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis, hot pickled mustard tube,
Radix Betae, Brassica campestris L, Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo, hami melon, Fructus Chaenomeliss, Fructus Mali pumilae, mandarin orange, peach tree, tea, wild vegetable, bamboo sprout, Flos lupuli (Flos Humuli Lupuli),
Fructus Piperiss, Fructus Musae, Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；The virus disease that described compounding anti-plant virus agent, activating plants agent are suitable for is selected from
Rice dwarf virus disease, BYDV, stripe virus disease, fern leaf of tomato viral disease, pepper mosaic virus disease viral disease, tobacco veinal necrosis virus disease,
Any one of maize dwarf mosaic, cauliflower mosaic viruses, Citrus virosiss, cymbidium mosaic virus, cybidium ring spot virus.
Embodiment 12
The isothiazole oxime ether derivatives of the present invention and agriculturally acceptable auxiliary agent and with following commodity acaricide in
Any one or more group is combined in prepares Compositional acaricide and its purposes in preventing and treating plant mites evil：
Described commodity acaricide is selected from azacyclotin, plictran, fenbutatin oxide, three phosphor tins, chlorfenviphos, dimethylvinphos, bar poison
Phosphorus, dichlorvos, heptenophos, Menites, Azodrin, 2-dichloroethylk dimethyl phosphate, chlopyrifos, Diothyl, imino-formyl chloride sulfur phosphorus, omethoate, enemy kill
Phosphorus, Ethodan, Malathion, methacrifos, Phosalone, phoxim, methylpyrimidine sulfur phosphorus, quintiofoss, sulfotep, triazophos,
Kilval, isocarbophoss, Bayer 71628, propetamphos, dialifos, phosmet, acrinathrin, Biphenthrin, chlorine fluorine cyanogen chrysanthemum
Ester, smart gamma cyhalothrin, Fenpropathrin, flucythrinate, flumethrin, taufluvalinate, brofluthrinate, biphenyl hydrazine
Ester, fenothiocarb, Aldicarb, butocarboxim, oxamyl, Talcord, thiofanox, benomyl, sok, carbofuran, fourth sulfur gram hundred
Prestige, meta-tolyl-N-methylcarbamate (MTMC), promacyl, Carzol, single carbonamidine, medimeform, Amitraz, Spanon, benzyl benzoate, fenisobromolate, fourth fluorine demodicid mite
Ester, acequinocyl, Nissol, Cascade, macro tetrolide, piericidin, thuringiensin, tetranactin, macro tetrolide, avilamycin,
Doractin, eprinomectin, ivermectin, selamectin, moxidectin, pyrethrin, nicotine, matrine, nimbin,
Rotenone, tebufenpyrad, pyridaben, fenpyroximate, clofentezine, propargite, Hexythiazox, Envidor, fluacrypyrim, chlorfenizon, propargite,
Pyridaben；In gained Compositional acaricide, total weight/mass percentage composition in the composition is the isothiazole oxime ether derivatives of the present invention
1%-90%, the isothiazole oxime ether derivatives of the present invention and the acaricidal ratio of described commodity arrive for mass percent 1%: 99%
99%: 1%；The dosage form of described Compositional acaricide is selected from wettable powder, micro-capsule suspension, dispersible body preparation, can divide
Scattered solid preparation, seed treatment Emulsion, aqueous emulsion, big granule, microemulsion, oil-suspending agent, the seed with coated pesticidal, water solublity
Granule, soluble thick agent, water-dispersible granules, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, CG/Encapsulated granule, dry mixing
Plant powder, cream, electrostatic spray agent, water in oil emulsion, oil in water emulsion, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog
Rod, seed treatment suspending agent, smog piece, smog ball, granular poison bait, foaming agent, drift powder, ointment, thermal fog, solid-liquid mix
Gu attaching together punishment, liquid liquid mixing dress agent, harl agent, solid/mixing dress agent, medicine paint, seed treatment liquor, microgranule, oil-dispersing property powder
Agent, lamellar poison bait, dense colloid, sprinkle pour agent, liniment, suspended emulsion, film forming oil preparation, soluble powder, seed treatment water solublity
Appointing in powder, ultra-low volume suspending agent, tracking powder, ultra low volume liquids, steam releasing agent, wet-mixing kind water-dispersible powder
Meaning is a kind of；Described Compositional acaricide be suitable for plant be selected from Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, Herba bromi japonici, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Ma Lingzhu,
Maninot esculenta crantz., Semen sojae atricolor, garden pea, Semen Viciae fabae, Semen Pisi sativi, Semen phaseoli radiati, Semen Phaseoli, Cotton Gossypii, silkworm and mulberry, Semen arachidis hypogaeae, Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, sweet
Sugarcane, coffee, cocoa, Radix Ginseng, Bulbus Fritillariae Uninbracteatae, rubber, Cortex cocois radiciss, Elaeis guineensis Jacq., Folium Agaves Sisalanae, Nicotiana tabacum L., Fructus Lycopersici esculenti, Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis,
Hot pickled mustard tube, Radix Betae, Brassica campestris L, Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo, hami melon, Fructus Chaenomeliss, Fructus Mali pumilae, mandarin orange, peach tree, tea, wild vegetable, bamboo sprout, beer
Hops, Fructus Piperiss, Fructus Musae, Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；Described Compositional acaricide be suitable for demodicid mite evil selected from Tetranychidae, Tenuipalpidae,
Furan line demodicid mite, Eriophyidae, tetranychus telariuses belong to, the evil mite of Eriophyidae, and these evil mites are worldwide Agricultural Mites, forestry harmful mites, gardening evil
Demodicid mite and health evil mite.
The chemical constitution of isothiazole oxime ether derivatives III of table 1 present invention and physical and chemical parameter
The bacteriostatic activity (suppression ratio/% of 50 mcg/ml) of the isothiazole oxime ether derivatives III of table 2 present invention
| Sequence number | Compound | AS | CA | GZ | PP | BC | SS | RC | PS | PI |
| 1 | CL01-35 | 93.1 | 82.4 | 94.7 | 97.70 | 82.90 | 92.60 | 98.50 | 98.00 | 100 |
| 2 | CL01-36A | 96.6 | 100 | 100 | 100 | 94.30 | 100 | 94.00 | 100 | 100 |
| 3 | CL01-36B | 51.7 | 47.1 | 52.6 | 90.70 | 51.40 | 85.20 | 68.70 | 84.00 | 77.60 |
| 4 | CL01-43 | 48.3 | 29.4 | 36.8 | 55.80 | 51.40 | 40.70 | 53.70 | 56.00 | 55.20 |
| 5 | CL01-48 | 68.18 | 64.29 | 80.95 | 100 | 100 | 87.50 | 92.31 | 100 | 59.09 |
| 6 | CL02-02 | 52.63 | 45.45 | 11.76 | 95.24 | 84.62 | 18.18 | 88.24 | 60.98 | 52.63 |
| 7 | CL02-03 | 56.78 | 36.98 | 67.31 | 39.85 | 24.76 | 45.73 | 11.65 | 17.98 | 47.94 |
| 8 | CL02-06 | 59.09 | 57.14 | 100 | 75.86 | 36.36 | 18.75 | 50.00 | 31.43 | 9.09 |
| 9 | CL02-09 | 13.64 | 7.14 | 19.05 | 13.79 | 9.09 | 52.08 | 65.38 | 62.86 | 4.55 |
| 10 | CL02-11 | 68.18 | 57.14 | 61.90 | 65.52 | 72.73 | 60.42 | 69.23 | 88.57 | 22.73 |
| 11 | CL02-16 | 68.18 | 50.00 | 71.43 | 100 | 18.18 | 18.75 | 65.38 | 100 | 77.27 |
| 14 | CL02-23 | 15.79 | 45.45 | 17.65 | 33.33 | 3.85 | 20.45 | 52.94 | 43.90 | 10.53 |
| 15 | CL02-33 | 15.79 | 27.27 | 17.65 | 47.62 | 30.77 | 56.82 | 35.29 | 26.83 | 31.58 |
| 16 | CL02-34 | 31.58 | 72.73 | 35.29 | 95.24 | 96.15 | 65.91 | 100 | 36.59 | 26.32 |
| 17 | CL02-35 | 36.84 | 9.09 | 5.88 | 85.71 | 69.23 | 40.91 | 82.35 | 53.66 | 31.58 |
| 18 | CL02-36 | 10.53 | 18.18 | 23.53 | 38.10 | 15.38 | 29.55 | 76.47 | 4.88 | 0 |
| 19 | CL02-37 | 0 | 0 | 5.88 | 14.29 | 30.77 | 15.91 | 11.76 | 9.76 | 21.05 |
| 20 | CL02-38 | 0 | 0 | 0 | 9.52 | 19.23 | 0 | 70.59 | 19.51 | 0 |
| 21 | CL02-43 | 50.34 | 18.97 | 27.89 | 78.40 | 55.64 | 56.59 | 18.92 | 34.65 | 6.34 |
| 22 | CL02-44 | 35.67 | 45.38 | 54.65 | 73.82 | 57.72 | 17.53 | 11.83 | 32.86 | 46.92 |
| 23 | CL02-45 | 22.73 | 21.43 | 9.52 | 48.28 | 0 | 10.42 | 84.62 | 65.71 | 13.64 |
| 24 | CLB01-15 | 13.56 | 54.87 | 52.76 | 8.63 | 8.99 | 13.67 | 24.63 | 27.85 | 47.98 |
| 26 | Fluoxastrobin | 46.88 | 55.56 | 75.00 | 91.18 | 71.43 | 100 | 88.10 | 84.06 | 80.77 |
Insecticidal activity (target mortality rate (%), 100 mg/litre of the isothiazole oxime ether derivatives III of table 3 present invention；Silkworm
Bean aphid 48 hours, other 72 hours)
| Numbering | Compound | Aphid | Numbering | Compound | Aphid |
| 1 | CL01-35 | 16.08 | 12 | CL02-23 | 9.91 |
| 2 | CL01-36A | 4.80 | 13 | CL02-33 | 20.83 |
| 3 | CL01-36B | 4.00 | 14 | CL02-34 | 11.15 |
| 4 | CL01-43 | 1.72 | 15 | CL02-35 | 2.83 |
| 5 | CL01-48 | 16.32 | 16 | CL02-36 | 10.46 |
| 6 | CL02-02 | 4.34 | 17 | CL02-37 | 6.63 |
| 7 | CL02-03 | 8.23 | 18 | CL02-38 | 6.78 |
| 8 | CL02-06 | 1.32 | 19 | CL02-43 | 3.56 |
| 9 | CL02-09 | 19.05 | 20 | CL02-44 | 5.81 |
| 10 | CL02-11 | 5.13 | 21 | CL02-45 | 3.76 |
| 11 | CL02-16 | 4.34 | 22 | CLB01-15 | 4.96 |
Activity (the suppression of 100 mcg/ml of the isothiazole oxime ether derivatives III resisting tobacco mosaic virus of table 4 present invention
Rate/%)
| Sequence number | Compound | Treatment | Passivation | Induction |
| 1 | CL01-35 | 38.30±4.34 | 52.00±4.55 | 52.33±4.96 |
| 2 | CL01-36A | 83.21±2.28 | 89.18±1.85 | 62.14±4.37 |
| 3 | CL01-36B | 26.93±3.13 | 95.26±3.62 | 16.12±0.28 |
| 4 | CL01-43 | 70.84±5.82 | 90.71±1.86 | 59.15±2.95 |
| 5 | CL01-48 | 49.93±1.79 | 82.66±4.75 | 18.53±2.15 |
| 6 | CL02-02 | 68.94±2.97 | 88.40±2.90 | 0 |
| 7 | CL02-03 | 91.26±2.51 | 44.18±4.82 | 57.35±5.44 |
| 8 | CL02-06 | 44.19±5.12 | 90.35±3.23 | 14.29±1.28 |
| 9 | CL02-09 | 5.20±0.48 | 90.60±5.20 | 3.62±2.26 |
| 10 | CL02-11 | 11.64±3.76 | 85.28±1.29 | 0 |
| 11 | CL02-16 | 20.85±4.34 | 85.38±3.80 | 2.71±0.71 |
| 12 | CL02-23 | 17.94±1.73 | 70.25±5.91 | 31.44±4.04 |
| 13 | CL02-33 | 88.14±2.28 | 27.06±6.14 | 47.68±3.55 |
| 14 | CL02-34 | 78.11±2.13 | 24.40±3.34 | 40.91±4.30 |
| 15 | CL02.35 | 27.76±2.82 | 31.18±2.73 | 32.18±4.72 |
| 16 | CL02-36 | 84.13±1.79 | 30.69±4.55 | 56.19±3.34 |
| 17 | CL02-37 | 39.02±2.97 | 93.45±1.85 | 48.73±1.46 |
| 18 | CL02-38 | 73.54±2.51 | 35.58±3.62 | 46.50±3.43 |
| 19 | CL02-43 | 31.17±2.12 | 36.96±1.86 | 47.57±2.59 |
| 20 | CL02-44 | 41.49±4.48 | 32.80±4.75 | 52.59±3.10 |
| 21 | CL02-45 | 36.37±3.76 | 40.40±2.59 | 35.67±4.74 |
| 22 | CLB01-15 | 31.65±2.28 | 35.65±4.82 | 41.12±5.32 |
| 23 | Ningnanmycin | 74.10±2.04 | - | - |
| 24 | TDL | - | - | 65.00±2.00 |
| 25 | BTH | - | - | 78.00±1.34 |
| 26 | SZG-7 | - | - | 79.00±2.27 |
| 27 | Virazole | - | 78.00±1.00 | - |
Claims (10)
1. class isothiazole oxime ether derivatives it is characterised in that：There is the general structure as shown in formula III：
III：
Wherein, R1It is selected from：Hydrogen, amino, methyl；R2It is selected from：Hydrogen, methyl, ethyl, 2- chloroethyl, pi-allyl, propargyl, 2- fourth
Alkynes -1- base, 2- octyne -1- base, 2- TRIFLUOROMETHYLBENZOYL.
2. the synthetic method of the isothiazole oxime ether derivatives III described in claim 1, according to raw material sources, concrete synthetic route
As follows：
When I is the aldehydes or ketones of isothiazole, i.e. R1During for hydrogen or methyl, the synthetic route of isothiazole oxime ether derivatives III is as follows：
Wherein, R1It is selected from：Hydrogen, methyl；R2It is selected from：Hydrogen, methyl, ethyl, 2- chloroethyl, pi-allyl, propargyl, 2-butyne -1-
Base, 2- octyne -1- base, 2- TRIFLUOROMETHYLBENZOYL；
Isothiazole oxime ether derivatives III can be with 3,4- bis- chloroisothiazole -5- first cyanogen for Material synthesis, and concrete route is as follows：
R2It is selected from：Hydrogen, methyl, ethyl, 2- chloroethyl, pi-allyl, propargyl, 2-butyne -1- base, 2- octyne -1- base, 2- trifluoro
Methyl benzoyl；
The synthesis concrete grammar of the isothiazole oxime ether derivatives III described in claim 1 is divided into following steps：
A. the preparation of compound II：
Add 1.12 mMs of compound I in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of ethanol, add 2.24 millis
Mole hydrochloride azanol, 0.11 gram of Deca triethylamine in final reaction system, that is, 1.12 mMs, it is stirred at room temperature 1 hour, has reacted
Removal of solvent under reduced pressure after entirely, with 10 milliliters of diluted ethyl acetate, adds 10 milliliters of water, isolates organic layer, and water layer is used
Twice of ethyl acetate back extraction, merges organic layer, and organic layer saturated sodium-chloride is washed one time, anhydrous sodium sulfate drying, sucking filtration, decompression
Remove solvent, residue obtains compound II through 200～300 mesh silica gel column chromatography purification, and eluant is 60～90 degrees Celsius of stone
Oily ether: ethyl acetate, according to the difference of product, volume ratio is 9: 1 to 2: 1, yield 80-95%；
B. the preparation method one of the isothiazole oxime ether derivatives III described in claim 1：
Add 1.02 mMs of compound II in 25 milliliters of single necked round bottom flask, dissolved with 15 milliliters of acetonitriles, add in reaction
Enter 0.21 gram, i.e. 1.53 mMs of potassium carbonate, in the most backward reaction system, add 1.53 mMs of R2- X, was stirred at room temperature
At night, reactant liquor is concentrated after terminating by reaction, and residue, with 10 milliliters of diluted ethyl acetate, adds 10 milliliters of water that solid is whole
Dissolving, isolates organic layer, aqueous layer with ethyl acetate back extraction one time, merges organic layer, organic layer saturated sodium-chloride is washed one time,
Anhydrous sodium sulfate drying, sucking filtration, removal of solvent under reduced pressure, residue obtains compound III through 200～300 mesh silica gel column chromatography purification,
Eluant is 60～90 degrees Celsius of petroleum ether: ethyl acetate, and according to the difference of product, volume ratio is 20: 1 to 8: 1, yield
25-85%；
C. the preparation method two of the isothiazole oxime ether derivatives III described in claim 1：
Add 2.36 mMs of compound II in 25 milliliters of single necked round bottom flask, dissolved with 5 milliliters of DMFs,
Add 1.15 grams in reaction, i.e. 3.54 mMs of cesium carbonates, add 3.54 mMs of R in the most backward reaction system2- X, room
Temperature stirring 2 hours, after reaction terminates, adds 10 milliliters of water in reactant liquor, is extracted with ethyl acetate, isolates organic layer,
Twice of aqueous layer with ethyl acetate back extraction, merges organic layer, and organic layer saturated sodium-chloride is washed one time, and anhydrous sodium sulfate drying is taken out
Filter, removal of solvent under reduced pressure, residue obtains white solid through 200～300 mesh silica gel column chromatography purification, and eluant is taken the photograph for 60～90
The petroleum ether of family name's degree: ethyl acetate, volume ratio is 20: 1, yield 23%；
D. the preparation method three of the isothiazole oxime ether derivatives III described in claim 1：
Add 1.03 mMs of compound II in 50 milliliters of single necked round bottom flask, dissolved with the dichloromethane a heatable brick bed of 25 milliliters of dryings,
Again to 0.13 gram of Deca triethylamine in reaction system, that is, 1.24 mMs, ice bath stir 15 minutes, ice bath stirring under after to
In reaction system, Deca is dissolved in the compound R of 1.24 mMs in 10 milliliters of dry methylene chloride2- X, is stirred overnight at room temperature,
Reactant liquor is concentrated after terminating by reaction, and residue from dichloromethane dissolves, and organic layer uses saturated sodium bicarbonate, saturated common salt successively
Water is respectively washed one time, anhydrous sodium sulfate drying, sucking filtration, and rotary evaporation removes solvent, and residue is through 200～300 mesh silica gel column chromatographies
Purification obtains white solid, and eluant is 60～90 degrees Celsius of petroleum ether: ethyl acetate, and volume ratio is 20: 1, yield 60-
70%；
E. the preparation method four of the isothiazole oxime ether derivatives III described in claim 1：
Add 0.55 mM of compound I or 3,4- bis- chloroisothiazole -5- first cyanogen in 25 milliliters of single necked round bottom flask, with 15 millis
Rise ethanol dissolving, then add 1.10 mMs of NH in reaction2OR2HCl, 0.11 gram of Deca triethylamine in final reaction system,
I.e. 1.10 mMs, it is stirred at room temperature 1 hour, removal of solvent under reduced pressure after reaction completely, with diluted ethyl acetate, add a small amount of
Water, isolates organic layer, aqueous layer with ethyl acetate back extraction one time, merges organic layer, and organic layer saturated sodium-chloride washes one time, no
Aqueous sodium persulfate is dried, sucking filtration, removal of solvent under reduced pressure, and residue obtains compound III through 200～300 mesh silica gel column chromatography purification, washes
De- agent is 60～90 degrees Celsius of petroleum ether: ethyl acetate, and according to the difference of product, volume ratio is 20: 1 to 9: 1, yield 60-
95%.
3. purposes in preparing insecticide for the isothiazole oxime ether derivatives described in claim 1.
4. purposes in preparing antibacterial for the isothiazole oxime ether derivatives described in claim 1.
5. purposes in preparing resisting tobacco mosaic virus agent for the isothiazole oxime ether derivatives described in claim 1.
6. purposes in preparing activating plants agent for the isothiazole oxime ether derivatives described in claim 1.
7. the isothiazole oxime ether derivatives described in claim 1 and agriculturally acceptable auxiliary agent and following one or more commodity
Purposes in preparing compounded pesticides for the insecticide composition；Described commodity insecticide is selected from：Chlopyrifos, sub- Nong, Acetamiprid, first
Amino avilamycin, milbemectin, avilamycin, pleocidin, fenvalerate, esfenvalerate, cypermethrin, efficient chlorine
Cyano chrysanthemate, Grenade (ICI)., decises, Fenpropathrin, cyfloxylate, Permanone, permethrin, propylene chrysanthemum
Ester, Biphenthrin, Permethrin, ethofenprox, flumethrin, fluvalinate, imidacloprid, Acetamiprid, Nitenpyram, chlorine
Thiophene quinoline, thiacloprid, Diacloden, clothianidin, MTI-446, clothianadin, Da Tenan, diflubenzuron, d ichlorbenzuron, Teflubenzuron, deinsectization are grand, fluorine
Bell urea, Cascade, pyridine worm are grand, lufenuron, poisonous insect urea, penfluron, Noviflumuron are noviflumuron, its CAS 121451-
02-3, flucycloxuron, Novaluron are Novaluron, chlorfluazuron, Bay sir 6874 is 1- [(3.5- bis- chloro- 4) 4- Nitrobenzol
Phenyl 3-3- (2- chlorobenzene)-urea, Bay SIR-8514 are 1- (4- Trifluoromethoxyphen-l) -3- (2- chlorobenzene)-urea, piperazine worm
Urea, Bistrifluron are bistrifluron, furan tebufenozide, tebufenozide, chlorine tebufenozide, methoxyfenozide, ring tebufenozide, pleasure
Really, omethoate, dichlorvos, orthene, triazophos, quintiofoss, pyridaphethione, isazofos, isoprocarb, sevin, anti-
Aphid prestige, meta-tolyl-N-methylcarbamate (MTMC), Mobucin, cartap, Bassa, leaf disperse, carbaryl, Benfuracard micro, carbosulfan, cartap,
Fenisobromolate, Hexythiazox, fenpyroximate, pyridaben, clofentezine, propargite, diafenthiuron, Benfuracard micro, pymetrozine, Envidor, spiral shell
Worm ester, spiral shell worm ethyl ester, butene-fipronil, azacyclotin, Buprofezin, phonamiphoss, ethiprole, Cupric sulfate, dimehypo, chlorantraniliprole,
Flubendiamide, fluorine cyanogen insect amide, cyanogen insect amide, Tolfenpyrad, tebufenpyrad, chlorfenapyr, pyrazinones, etoxazole, tebufenpyrad, rattle away children
Ketone, Nylar, emaricin；Total matter in gained compounded pesticides for the isothiazole oxime ether derivatives described in claim 1
Amount percentage composition is 1%-90%, and the ratio of the isothiazole oxime ether derivatives described in claim 1 and described commodity insecticide is
Mass percent 1%: 99% to 99%: 1%；Described compounded pesticides be suitable for dosage form be selected from seed treatment Emulsion, aqueous emulsion,
Big granule, microemulsion, water-soluble granule, soluble thick agent, water-dispersible granules, poison grain, aerosol, block poison bait, sustained-release block,
Dense poison bait, CG/Encapsulated granule, micro-capsule suspension, Waterless Seed Dressing powder, cream, electrostatic spray agent, water in oil emulsion, oil-in-water breast
Agent, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog rod, seed treatment suspending agent, smog piece, smog ball, granular poison bait,
Thermal fog, medicine paint, microgranule, oil suspending agent, oil-dispersing property powder, lamellar poison bait, dense colloid, sprinkle pour agent, seed coat agent, liniment,
Suspended emulsion, film forming oil preparation, soluble powder, seed treatment water solube powder, ultra-low volume suspending agent, follow the trail of powder, ultralow
Any one in volume liquids, wet-mixing kind water-dispersible powder；The plant that described compounded pesticides are suitable for is selected from Oryza glutinosa, little
Wheat, Fructus Hordei Vulgaris, Herba bromi japonici, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Rhizoma Solani tuber osi, Maninot esculenta crantz., Semen sojae atricolor, garden pea, Semen Viciae fabae, Semen Pisi sativi, Semen phaseoli radiati, Semen Phaseoli, Cotton Gossypii,
Silkworm and mulberry, Semen arachidis hypogaeae, Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, Caulis Sacchari sinensis, coffee, cocoa, Radix Ginseng, Bulbus Fritillariae Uninbracteatae, rubber, Cortex cocois radiciss, Elaeis guineensis Jacq., Folium Agaves Sisalanae,
Nicotiana tabacum L., Fructus Lycopersici esculenti, Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis, hot pickled mustard tube, Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo, hami melon, Fructus Chaenomeliss, Fructus Mali pumilae, Citrus chachiensis Hort.
Fructus Citri tangerinae, peach tree, tea, wild vegetable, bamboo sprout, Flos lupuli (Flos Humuli Lupuli), Fructus Piperiss, Fructus Musae, Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；Described compounded pesticides preventing and treating
Insect pest is selected from Locusta migratoria manilensis (Meyen), reading room management, Chinese rice grasshopper, Patanga japonica (l.Bol.), single thorn Gryllotalpa, Oriental burmeister, rice thripses, cigarette Ji
Horse, greenhouse thrips, haplothrips aculeatus, Mai Jian pipe thrips, Trialeurodes vaporariorum Westwood, Bemisia tabaci, rice green leafhopper, green leaf hopper, chlorita biguttula, speckle
Clothing plant hopper, brown paddy plant hopper, white backed planthopper, small brown rice planthopper, Caulis Sacchari sinensis flat angle plant hopper, cotten aphid, green bugs, grain aphid, black peach aphid, Sorghum vulgare Pers.
Aphid, radish aphid, icerya purchasi, Pseudaulacaspis pentagona, unaspis shield kuwana, san jose scale, wax insect, ceroplastes rubens, Didesmococcus koreanus Borchs, pear lace bug, Fructus Musae net
Stinkbug, thin corner piece stinkbug, Orius minutus, slender rice bug, paddy fly, niphe elongata, scotinophora lurida, Nezara viridula smaragdula Fabricius., green plant bug, alfalfa plant bug, in
Optic atrophy stinkbug, chrysopa septempunctata, beautiful Chrysopa, Chinese green lacewing, rain moth, casemaking clothes moth, cnidocampa flavescens walker, brown Limacodidae, thosea siensis, gelechiid, pink bollworm, sweet
Potato gelechiid, diamondback moth, small heart-eating peach worm, eating-core bean worm, small heart-eating peach worm, Fructus Mali pumilae Spilonota lechriaspis, brown belt length leaf roller, plan
Smaller apple leaf roller, striped rice borer, bean-pod borer, Pyrausta nubilalis (Hubern)., yellow rice borer, Oeobia undalis, rice leaf roller, bar snout moth's larva, Notarchaderogata, Fructus Persicae moth
Snout moth's larva, armyworm, Prodenia litura, rice green caterpillar, anomis flava, beet armyworm, pink rice borer, bollworm, ancient cooking vessel point diamond, black cutworm,
Big cutworm, yellow cutworm, robber acute tonsillitis, gypsymoth, palaearctic sweet potato, greenish brown hawk moth, straight burr rice hesperiidae, pelopidas mathias, Citrus phoenix
Butterfly, Common Mormon, cabbage butterfly, pyrameis indica, a Boehmeria Huang a kind of butterfly harmful to crop plants, bean brassica rapa, Venus ground beetle, wrinkle sheath ground beetle, wheat head ground beetle, ditch
The little buprestid beetle of wireworm, Agriotes subrittatus Motschulsky, khapra beetle, attagenus piceus, Citrus, golden edge buprestid beetle, tenebrio molitor, dark mealworm, red plan
Ostomatid, confused flour beetle, Aerugo different beetle, H. parallela, holotrichia oblita, mulberry borer, longicorn beetle, nadezhdiella cantori, Fructus Persicae
Red neck Anoplophorae seu Aprionae, big daikon leaf beetle, daicon leaf beetle, aulacophora femoralises, phyllotreta striolata, Callosobruchus chinensises, pea weevil, broad bean weevil, sitophilus zea-maises, rice
As, dolerus tritici, pear fruit sawfly, fulminant leucorrhagia with yellowish discharge ichneumon wasp, armyworm white star ichneumon wasp, corn earworm hang cocoon ichneumon wasp, Campoletis chlorideae, snout moth's larva stain wart
Ichneumon wasp, mosquito, fly, horsefly, wheat midge, contarinia tritici, pachydiplosis oryzae, citrus fruit fly, melonfly, wheat leaf ash latent fly, America
Liriomyza bryoniae, Soybean stem borer, frit fly, Hylemyia Platura Meigen, onion fly, Radix Raphani fly, full skirt Exorista civilis, Pyrausta nubilalis (Hubern). are strict to post fly, armyworm.
8. the isothiazole oxime ether derivatives described in claim 1 and agriculturally acceptable auxiliary agent and following commodity antibacterial
In any one or more group be combined in the purposes preparing in composite bactericide；Described commodity antibacterial be selected from diazosulfide,
Tiadinil, first thiophene lure amine, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- formic acid, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- sodium formates, 4-
Methyl isophthalic acid, 2,3- thiadiazoles -5- Ethyl formates, 4- bromomethyl -1,2,3- thiadiazoles -5- Ethyl formates, 4- iodomethyl -1,2,3-
Thiadiazoles -5- Ethyl formate, 4- bromomethyl -5- methyl isophthalic acid, 2,3- thiadiazoles, 4- iodomethyl -5- methyl isophthalic acid, 2,3- thiadiazoles,
4,4- dibromo methyl isophthalic acids, 2,3- thiadiazoles -5- Ethyl formates, 3,4- bis- chloroisothiazole -5- formic acid, 3,4- bis- chloroisothiazole -5-
Sodium formate, 3,4- bis- chloroisothiazole -5- Ethyl formate, DL- beta-aminobutyric acid, isotianil, virazole, antofine, Ningnan are mould
Element, first thiophene lure amine, salicylic acid, cytosintetidemycin, dichloro-isonicotinic acid, allyl isothiazole, cymoxanil, thiram, ziram, maneb
Zinc, AL-PHOSETHYL aluminum tris(ethyl phosphite), thiophanate-methyl, Bravo, enemy can pine, procymidone, fenpropidin, thiophanate methyl, thiophanate, Metalaxyl-M,
Salicylic acid, flumorph, dimethomorph, mefenoxam, benalaxyl-M, double chlorine zarilamid, flusulfamide, first flusulfamide, thiophene fluorine
Bacterium amine, flutolanil, tecloftalam, ring propionyl bacterium amine, cyflufenamid, fenhexamid, zarilamid, Silthiopham, furametpyr, pyrrole thiophene
The phonetic bacterium of bacterium amine, mandipropamid, zoxamide, fenfuram, carboxin, chlozolinate, RP-26019, Fluoxastrobin, dimoxystrobin, fluorine
Ester, kresoxim-methyl, SSF 126, orysastrobin, ZEN 90160, pyraclostrobin, trifloxystrobin, Enestroburin, alkene oxime amine, oxygen ring
Azoles, bromuconazole, SAN-619F, Difenoconazole, olefin conversion, efficient olefin conversion, epoxiconazole, RH-7592, Fluquinconazole, bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-ylmethyl)silane,
Flutriafol, hexaconazole, glyoxalin, kind bacterium azoles, metconazole, nitrile bacterium azoles, Wu Junzuo, propiconazole, prothioconazoles, simeconazoles, penta azoles
Alcohol, tetraconazole, Triadimenol, triticonazole, bitertanol, probenazole, furidazol, imazalil, efficient imazalil, Prochloraz,
Fluorine bacterium azoles, cyazofamid, Fenamidone, imidazoles, pefurazoate, cycloheximide triazole, pyridine bacterium azoles, mould spirit, frost spirit, thiazole bacterium
Amine, Grandox fumigant, octhilinone, benthiozole, dodemorph, butadiene morpholine, tridemorph, fenpiclonil, CGA-173506, fluazinam,
Pyrifenox, ring pyridine bacterium amine, Boscalid, fluopicolide, pyridine bacterium amine, cyprodinil, fluorine mepanipyrim, ferimzone, mepanipyrim, phonetic
Mould amine, Fenarimol, nuarimol, chinomethionat, dithianon, ethoxyquin, hydroxyquinoline, the third oxygen quinoline, benzene oxygen quinoline
Quinoline, diethofencarb, iprovalicarb, benzene metsulfovax, Propamocarb, methasulfocarb, edifenphoses, iprobenfos, pyrazophos, tolelofos-methyl,
Blasticidin-Ss, kasugarnycin, polyoxin, Polyoxin, valida, jingganmycin, streptomycin, metalaxyl, furalaxyl, benzene frost
Spirit, ofurace, mebenil, carbendazim, benomyl, thiophanate-methyl, triazolone, bupirimate, dimethirimol, second are phonetic
Phenol, difoltan, captan, folpet, vinclozolin, fluoromide, dimethachlon, Isoprothiolane, kitazine, Yekuzuo, five
Chloronitrobenzene, Mancozeb, Propineb, phosethyl-Al, sulfur, Bordeaux mixture, copper sulfate, copper oxychloride, Red copper oxide, hydrogen
Copper oxide, metrafenone, Pencycuron, diclomezin, Rabcide, pyroquilon, volution bacterium amine, tricyclazole, triforine, the pyridine of many fruits, double
The pungent salt of guanidine, iminoctadine, botran, benzene flusulfamide, toluene flusulfamide, indocate, fenaminosulf, oxolinic acide, probenazole, bromine
Nitre alcohol, iodine first a heatable brick bed, metham-sodium, enemy line ester, dazomet, nemamort, lythidathion, cadusafos, O,O-diethyl O-[p-(methylsulfinyl)phenyl, thionazin, fenamiphos,
The different cigarette of phonamiphoss, O-2,4-dichlorophenyl O,O-diethyl phosphorothioate, isazofos, fosthietan, oxamyl, Aldicarb, carbofuran, vikane, dichloropropylene, dichloro
Acid, allyl isothiazole；Total percent mass in gained composite bactericide for the isothiazole oxime ether derivatives described in claim 1
Content is 1%-90%, and the ratio of the isothiazole oxime ether derivatives described in claim 1 and described commodity antibacterial is quality hundred
Divide and compare 1%: 99% to 99%: 1%；The dosage form that described composite bactericide is suitable for is selected from any one in following dosage forms：Wettable
Property powder, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment Emulsion, aqueous emulsion, big granule,
Microemulsion, oil-suspending agent, the seed with coated pesticidal, water-soluble granule, soluble thick agent, water-dispersible granules, poison grain, aerosol
Agent, block poison bait, sustained-release block, dense poison bait, CG/Encapsulated granule, Waterless Seed Dressing powder, cream, electrostatic spray agent, water in oil emulsion, Shui Bao
Oil emulsion, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog rod, seed treatment suspending agent, smog piece, smog ball, granular poison
Bait, thermal fog, medicine paint, seed treatment liquor, microgranule, oil-dispersing property powder, lamellar poison bait, dense colloid, sprinkle pour agent, smear
Agent, suspended emulsion, film forming oil preparation, soluble powder, seed treatment water solube powder, ultra-low volume suspending agent, follow the trail of powder, super
Low capacity liquor, wet-mixing kind water-dispersible powder；The plant that described composite bactericide is suitable for is selected from Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, swallow
Wheat, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Rhizoma Solani tuber osi, Maninot esculenta crantz., Semen sojae atricolor, garden pea, Semen Viciae fabae, Semen Pisi sativi, Semen phaseoli radiati, Semen Phaseoli, Cotton Gossypii, silkworm and mulberry, Semen arachidis hypogaeae,
Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, Caulis Sacchari sinensis, coffee, cocoa, Radix Ginseng, Bulbus Fritillariae Uninbracteatae, rubber, Cortex cocois radiciss, Elaeis guineensis Jacq., Folium Agaves Sisalanae, Nicotiana tabacum L., Fructus Lycopersici esculenti,
Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis, hot pickled mustard tube, Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo, hami melon, Fructus Chaenomeliss, Fructus Mali pumilae, mandarin orange, peach tree, tea,
Wild vegetable, bamboo sprout, Flos lupuli (Flos Humuli Lupuli), Fructus Piperiss, Fructus Musae, Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；The controlling disease choosing that described composite bactericide is suitable for
From：Mould leaf blight, Semen Tritici aestivi compacted spore leaf spot, little avenged by wheat rust, wheat scab, wheat powdery mildew, wheat virus disease, Semen Tritici aestivi
Wheat smut, take-all, wheat sharp eyespot, Semen Tritici aestivi downy mildew, the late blight of potato, wart of potatoes, Rhizoma Solani tuber osi skin ulcer
Scall, target, bacterial ring rot o potato, potato bacterial wilt, blakleg of potato, Potyviruses and viroid disease
Evil, bacterial soft rot of potato, dry rot of potato, Rhizoma Solani tuber osi verticillium wilt, black scurf of potato, potato bacterial wilt, Rhizoma Solani tuber osi ring
Maize ear rot, blakleg of potato, bacterial soft rot of potato, cotton wilt, cotton verticillium wilt, angular leaf spot of cotton, red leaf blight, Cotton Gossypii
Damping-off, Cotton Gossypii damping off, cotton anthracnose, cotton spoting verticillium wilt, cotton anthracnose, cotton spoting verticillium wilt, rice blast,
Rice sheath blight disease, water rice brown spot, small round sclerotial disease of rice, bakanae disease of rice, downymildewofrice, rice green smut, water
Sheath rot of rice plant, bacterial blight of rice, bacterial leaf streak of rice, Characters of Erwinia chrysanthemi pv. zeae, stripe disease, water
Rice black streak dwarf, Oryza sativa L. rice black sclerotium stalk rot, the leaf blight of corn, corn southern leaf blight, Helminthosporium carbonum, Semen Maydiss brown patch
Disease, maize sheath blight, corn rust, maize head smut, Corn Stalk Rot, corn smut, Semen Maydiss dry rot, Semen Maydiss virus
Disease and corn stalk rot disease, sclerotinia rot of colza, Rape virus disease, oilseed rape downy mildew, white rust of colza, root rot, Semen sojae atricolor bacterium
Core disease, grey speck of soybean, soybean Mosaic, soy bean cyst roundworm, root-knot nematode, soybean rust, soybean anthracnose,
Bacterial pustule of soybean, Semen sojae atricolor spot blight, downy mildew, bacterial wilt of peanut, Diplodia gossypina, Semen arachidis hypogaeae root rot, Semen arachidis hypogaeae
Brown spot, Peanut Web Blotch Disease, activity of peanuts disease, Peanut Scab, tobacco bacterial wilt, wildfire, Nicotiana tabacum L. hollw stalk, Nicotiana tabacum L.
Angular leaf spot, black shank, Alternaria alternate, frog-eye leaf spot of tobacco, anthracnose of tobacco, black root of tobacco, fusarium tabacinum root
Maize ear rot, Tobacco seedling diseases, Nicotiana tabacum L. damping-off, Nicotiana tabacum L. junk leaf spot, Powdery Mildew in Tobacco, Nicotiana tabacum L. southern blight, Nicotiana tabacum L. melasma, cigarette
Showy flowers of herbaceous plants leaf disease, cucumber mosaic virus, etch virus of tobacco, Chinese cabbage downy mildew, soft rot of cabbage, Chinese cabbage Tipburn Disease, Chinese cabbage virosiss,
Cabbage Leaf Spot, Seed detection, Chinese cabbage anthrax, cabbage clubroot, bacterial spot of tomato, tomato late blight, Fructus Lycopersici esculenti
Blossom-end rot, Fructus Lycopersici esculenti powdery mildew, Fructus Lycopersici esculenti damping off, Fructus Lycopersici esculenti Flos Pelargonii mosaic disease, tomato bacterial speck, tomato yellow leaf curl
Poison, leaf muld of tomato, tomato virus disease, tomato late blight, Fructus Lycopersici esculenti damping off and damping-off, Fructus Lycopersici esculenti deform fruit, Fructus Lycopersici esculenti is bored a hole really,
Tomato black ring virus disease, Fructus Lycopersici esculenti rot stem nematodes disease, tamato fruit buphthalmos disease, Fructus Lycopersici esculenti stain root rot, Fructus Lycopersici esculenti stain root rot,
Fructus Lycopersici esculenti branch spore fruit rot, Fructus Lycopersici esculenti heartrot, Fructus Lycopersici esculenti Rhizopus fruit rot, Fructus Lycopersici esculenti low temperature obstacle, Fructus Lycopersici esculenti bolter, Fructus Lycopersici esculenti physiological volume
Leaf disease, Fructus Lycopersici esculenti damping off, Fructus Lycopersici esculenti fruit drop disease, Fructus Lycopersici esculenti bud blight, Tomato soft rot, Fructus Lycopersici esculenti stem rot, tomato seedling damping-off,
The rotten fruit of Fructus Lycopersici esculenti sun burn, Fructus Lycopersici esculenti shot hole, Fructus Lycopersici esculenti Hydrargyri Oxydum Rubrum disease, tomato virus disease, Fructus Lycopersici esculenti cracked fruit, canker of tomato, Fructus Lycopersici esculenti umbilicuss,
Fructus Lycopersici esculenti Semen Sesami pinta bacterium, bacterial spot of tomato, Fructus Lycopersici esculenti rot leaf viral disease, tomato yellow leaf curl virus disease, Fructus Solani melongenae cotton disease,
Fructus Solani melongenae sclerotiniose, Fructus Solani melongenae bacterial wilt, Fructus Solani melongenae Phomopisis vexans, eggplant verticillium wilt, Fructus Solani melongenae leaf spot, Fructus Solani melongenae early blight, Fructus Solani melongenae virosiss,
Fructus Solani melongenae leaf spot disease, Fructus Solani melongenae leaf mold, Fructus Solani melongenae powdery mildew, Fructus Solani melongenae spot disease, Fructus Solani melongenae coal spot disease, cercospora leaf spot of egg plant, Fructus Solani melongenae are black
Rot, Fructus Solani melongenae epidemic disease, eggplant anthracnose, Fructus Solani melongenae rhizopus soft rot, wilt of eggplant, grey mould of egg plant, Fructus Solani melongenae base rot disease, peppery
Green pepper Capsicum annuum L. virosiss, Fructus Capsici early blight, Fructus Capsici leukoderma, pepper white star disease, Fructus Capsici leaf spot, Fructus Capsici Scald, Fructus Capsici dirt are mould
Disease, capsicum wilt, Fructus Capsici sclerotiniose, Fructus Capsici sunscald, pepper virus disease, Fructus Capsici malformed fruit, Fructus Capsici blossom-end rot, the soft corruption of Fructus Capsici
Disease, bacterial spot of pepper, Fructus Capsici bar virus scab, Fructus Capsici pythium rot, macrosporium leaf spot of red pepper, Fructus Capsici spot blight, Fructus Capsici melasma, Fructus Capsici
Verticillium wilt, pepper bacterial leaf spot, Fructus Capsici brown rot, Fusarium solani, Fructus Capsici damping-off, pepper anthracnose, Fructus Capsici brown patch
Disease, Fructus Capsici downy mildew, Botrytis cinerea, Fructus Capsici leaf blight, pepper leaf mold, Fructus Capsici damping off, capsicum epidemic disease, Fructus Vitis viniferae downy mildew
Disease, uncinula necator, brown spot of grape, grapevine leafroll disease, Grapevine Fan Leaf Virus Disease, Fructus Vitis viniferae rust, Fructus Vitis viniferae ring spot, Fructus Vitis viniferae tikka
Disease, the little brown spot of Fructus Vitis viniferae, Fructus Vitis viniferae zonate spot, Fructus Vitis viniferae graywall, Fructus Vitis viniferae young sprout wasting disease, Fructus Vitis viniferae mosaic disease, Fructus Vitis viniferae wasting disease, Portugal
The golden yellow disease of grape stripe disease, Fructus Vitis viniferae, Fructus Vitis viniferae infectivity necrosis disease, Fructus Vitis viniferae Huang select disease, Fructus Vitis viniferae lug disease, Fructus Vitis viniferae vein necrosis disease, Portugal
Grape spot disease viral disease, the starlike mosaic disease of Fructus Vitis viniferae, Fructus Vitis viniferae Pearls, fruit white rot of grape, bitter rot or anthracnose of grape, Fructus Vitis viniferae room rot, Portugal
Grape gray mold, grapevine anthracnose, black rot of grape, Fructus Vitis viniferae big room rot, Fructus Vitis viniferae coal select disease, Fructus Vitis viniferae brown select disease, the mould dirty disease of Fructus Vitis viniferae,
Fructus Vitis viniferae bitter rot, grape branch spore rot, Fructus Vitis viniferae penicilliosiss, Fructus Vitis viniferae Alternaria rot, apple tree canker, Fructus Mali pumilae dry rot
Disease, ring rot of apple, Fructus Mali pumilae branch Peptic Ulcerss, Fructus Mali pumilae bleb Peptic Ulcerss, Pink Disease of Apple, Fructus Mali pumilae die back disease, Fructus Mali pumilae branch-rot, Herba Marsileae Quadrifoliae
Fruit anthrax, Apple Mould Core, rust of apple (Gymnosporangium yamadai), Fructus Mali pumilae blossom rot, apple brown rot, black fruit rot of apple, Fructus Mali pumilae phytophthora rot, Fructus Mali pumilae
Sooty mould, sick apple marssonina leaf spot, alternaria leaf spot of apple, Glomerella cingulata, Fructus Mali pumilae graywall, apple mildew, the black star of Fructus Mali pumilae
Disease, silver leaf of apple, Fructus Mali pumilae infectivity root rot, armillariella root rot of apple, Fructus Mali pumilae Root-rot disease, Fructus Mali pumilae southern blight, apple violet root rot,
Rosellinia trunk rot of apple, Apple crown gall, Fructus Mali pumilae decline disease, apple rough skin disease, apple mosaic, apple green wrinkle fruit disease, Fructus Mali pumilae contracting
Fruit disease, Apple little leaf, apple chlorosis, Fructus Mali pumilae bitter pit, Fructus Mali pumilae water core, apple superficial scald, carbuncle apple scab, gold
Hat Fructus Mali pumilae fruit russeting, green mold of apple, Fructus Mali pumilae soft rot, Apples meat powder silk floss disease, apple pulp brown stain disease, Fructus Mali pumilae brown heart, pears
Scab, black rot of pear, Fungus of Pear Canker Disease, pears southern blight, pear tree wood rot, pears die back disease, rust of pear, Pear black spot, pears ash
Pinta, pears brown spot, pears Socty Blotch And Greasy Blotch, pears top rot, pears fruit-shrink disease, pears yellowtop, anthracnose of peach, Fructus Persicae reality maize ear rot, peach fruit maize ear rot,
Fructus Persicae soft rot, Fructus Persicae Peptic Ulcerss, peach tree powdery mildew, peach brown rot, peach scab, the abnormal fruit disease of Fructus Persicae, peach tree sooty mould, peach tree leaf curl
Disease, peach tree fungoids shothole disease, peach tree Bacterial septicaemia syndrome, peach leaves pinta, peach tree leaf rust, peach tree mosaic disease, peach tree are red
Leaf disease, peach tree canker, peach gummosis, peach tree wood rot, peach tree die back disease, Peach crown gall, peach tree root rot, Radix Persicae
The broken leaf disease of Root-knot, Citrus Huanglongbing pathogen, exocortis, Citrus, citrus decline, Satsuma dwarf virus, c itrus canker
Disease, citrus scab, citrus anthracnose, Citrus foot rot, Citrus resin disease, Citrus bleeding disease, Citrus fuliginous, Citrus white lead
Disease, Citrus fat select maculopathy, Citrus are intended fat and selected maculopathy, Citrus red clothing disease, Citrus felt fungus, Citrus seedling blight, Citrus
Seedling epidemic disease, banana bunchy top disease, Banana Mosaic Disease, research of fusarium wilt disesase of banana, Cercospora musae bacterium leaf spot, Fructus Musae secretly double spores
The mould leaf spot of the little Dou Shi of mould leaf spot, Fructus Musae, banana freckle, Banana Leaf pestilence, banana anthracnose, banana crown rot, Caulis et Folium Brassicae capitatae
Bacterial black rot, cottony rot of cabbage, cabbage black rot, black spot of cabbage, Caulis et Folium Brassicae capitatae brown spot, Caulis et Folium Brassicae capitatae blastomere disease, Caulis et Folium Brassicae capitatae virus
Disease, Caulis et Folium Brassicae capitatae soft rot, Caulis et Folium Brassicae capitatae bolting disease, cabbage downy mildew, Caulis et Folium Brassicae capitatae anthrax, black leg of cabbage, Caulis Sacchari sinensis pineapple disease, Caulis Sacchari sinensis in advance
Smut, sugarcane ratoon stunting disease, Caulis Sacchari sinensis brown streak, sugarcane rust, Sorghum vulgare Pers. smut, Sorghum vulgare Pers. leaf spot, Sorghum vulgare Pers. anthrax, height
Beam leaf blight, Sorghum vulgare Pers. virosiss.
9. the isothiazole oxime ether derivatives described in claim 1 and agriculturally acceptable auxiliary agent and with following commodity antiviral
Any one or more group in agent is combined in the compounding anti-plant virus agent of preparation, the purposes in activating plants agent；Described commodity resist
Viral agent is selected from：Diazosulfide, tiadinil, first thiophene lure amine, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- formic acid, 4- methyl isophthalic acid,
2,3- thiadiazoles -5- sodium formates, 4- methyl isophthalic acid, 2,3- thiadiazoles -5- Ethyl formates, 4- bromomethyl -1,2,3- thiadiazoles -5- first
Acetoacetic ester, 4- iodomethyl -1,2,3- thiadiazoles -5- Ethyl formates, 4- bromomethyl -5- methyl isophthalic acid, 2,3- thiadiazoles, 4- iodine first
Base -5- methyl isophthalic acid, 2,3- thiadiazoles, 4,4- dibromo methyl isophthalic acid, 2,3- thiadiazoles -5- Ethyl formates, 3,4- bis- chloroisothiazole -5-
Formic acid, 3,4- bis- chloroisothiazole -5- sodium formate, 3,4- bis- chloroisothiazole -5- Ethyl formate, DL- beta-aminobutyric acid, virazole,
Antofine, Ningnanmycin, first thiophene lure amine, salicylic acid, cytosintetidemycin, dichloro-isonicotinic acid, allyl isothiazole, well ridge azanol, Jing Gang
Mycin；Isothiazole oxime ether derivatives described in claim 1 are total in the compounding anti-plant virus agent of gained, activating plants agent
Weight/mass percentage composition is 1%-90%, the ratio of the isothiazole oxime ether derivatives described in claim 1 and described commodity antiviral agent
Example is mass percent 1%: 99% to 99%: 1%；Described compounding anti-plant virus agent, activating plants agent dosage form be selected from can
WP, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment Emulsion, aqueous emulsion, big grain
Agent, microemulsion, oil-suspending agent, with the seed of coated pesticidal, water-soluble granule, soluble thick agent, water-dispersible granules, poison grain,
Aerosol, block poison bait, sustained-release block, dense poison bait, CG/Encapsulated granule, Waterless Seed Dressing powder, cream, electrostatic spray agent, water in oil emulsion,
Oil in water emulsion, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog rod, seed treatment suspending agent, smog piece, smog ball, grain
Shape poison bait, thermal fog, medicine paint, seed treatment liquor, microgranule, oil-dispersing property powder, lamellar poison bait, dense colloid, sprinkle pour agent, painting
Smear agent, suspended emulsion, film forming oil preparation, soluble powder, seed treatment water solube powder, ultra-low volume suspending agent, follow the trail of powder,
Any one in ultra low volume liquids, wet-mixing kind water-dispersible powder；Described compounding anti-plant virus agent, activating plants agent are fitted
Plant be selected from Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, Herba bromi japonici, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Rhizoma Solani tuber osi, Maninot esculenta crantz., Semen sojae atricolor, garden pea, Semen Viciae fabae,
Semen Pisi sativi, Semen phaseoli radiati, Semen Phaseoli, Cotton Gossypii, silkworm and mulberry, Semen arachidis hypogaeae, Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, Caulis Sacchari sinensis, coffee, cocoa, Radix Ginseng, Bulbus Fritillariae Uninbracteatae,
Rubber, Cortex cocois radiciss, Elaeis guineensis Jacq., Folium Agaves Sisalanae, Nicotiana tabacum L., Fructus Lycopersici esculenti, Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis, hot pickled mustard tube, Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo,
Hami melon, Fructus Chaenomeliss, Fructus Mali pumilae, mandarin orange, peach tree, tea, wild vegetable, bamboo sprout, Flos lupuli (Flos Humuli Lupuli), Fructus Piperiss, Fructus Musae, Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；
The virus disease that described compounding anti-plant virus agent, activating plants agent are suitable for is withered selected from rice dwarf virus disease, BYDV, striped leaf
Disease, fern leaf of tomato viral disease, pepper mosaic virus disease viral disease, tobacco veinal necrosis virus disease, maize dwarf mosaic, cauliflower mosaic
Poison, any one of Citrus virosiss, cymbidium mosaic virus, cybidium ring spot virus.
10. the isothiazole oxime ether derivatives described in claim 1 and agriculturally acceptable auxiliary agent and with following commodity mite killing
Any one or more group in agent is combined in prepares Compositional acaricide and its purposes in preventing and treating plant mites evil；Described commodity kill
Demodicid mite agent is selected from azacyclotin, plictran, fenbutatin oxide, three phosphor tins, chlorfenviphos, dimethylvinphos, crotoxyphos, dichlorvos, heptenophos, speed
Go out phosphorus, Azodrin, 2-dichloroethylk dimethyl phosphate, chlopyrifos, Diothyl, imino-formyl chloride sulfur phosphorus, omethoate, dioxathion, Ethodan, Malathion,
Methacrifos, Phosalone, phoxim, methylpyrimidine sulfur phosphorus, quintiofoss, sulfotep, triazophos, Kilval, isocarbophoss, methylamine
Phosphorus, propetamphos, dialifos, phosmet, acrinathrin, Biphenthrin, lambda-cyhalothrin, smart gamma cyhalothrin,
Fenpropathrin, flucythrinate, flumethrin, taufluvalinate, brofluthrinate, Bifenazate, fenothiocarb, Aldicarb, fourth
Ketone prestige, oxamyl, Talcord, thiofanox, benomyl, sok, carbofuran, carbosulfan, meta-tolyl-N-methylcarbamate (MTMC), promacyl, cut down
Worm amidine, single carbonamidine, medimeform, Amitraz, Spanon, benzyl benzoate, fenisobromolate, cyflumetofen, acequinocyl, Nissol, fluorine
Worm urea, macro tetrolide, piericidin, thuringiensin, tetranactin, macro tetrolide, avilamycin, doractin, Ai Pulinuo bacterium
Element, ivermectin, selamectin, moxidectin, pyrethrin, nicotine, matrine, nimbin, rotenone, tebufenpyrad, demodicid mite of rattling away
Ketone, fenpyroximate, clofentezine, propargite, Hexythiazox, Envidor, fluacrypyrim, chlorfenizon, propargite, pyridaben；Claim 1 institute
In gained Compositional acaricide, total weight/mass percentage composition in the composition is 1%-90% to the isothiazole oxime ether derivatives stated, power
It is mass percent 1%: 99% to 99% that profit requires isothiazole oxime ether derivatives described in 1 and the acaricidal ratio of described commodity
: 1%；The dosage form of described Compositional acaricide is selected from wettable powder, micro-capsule suspension, dispersible body preparation, dispersibles admittedly
Body preparation, seed treatment Emulsion, aqueous emulsion, big granule, microemulsion, oil-suspending agent, the seed with coated pesticidal, water solublity grain
Agent, soluble thick agent, water-dispersible granules, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, CG/Encapsulated granule, Waterless Seed Dressing
Powder, cream, electrostatic spray agent, water in oil emulsion, oil in water emulsion, smoke candle, granula subtilises, smoke candle, smoke cartridge, smog
Rod, seed treatment suspending agent, smog piece, smog ball, granular poison bait, thermal fog, medicine paint, seed treatment liquor, microgranule, oil
Scattered property powder, lamellar poison bait, dense colloid, sprinkle pour agent, liniment, suspended emulsion, film forming oil preparation, soluble powder, seed treatment
Any one in water solube powder, ultra-low volume suspending agent, tracking powder, ultra low volume liquids, wet-mixing kind water-dispersible powder
Kind；The plant that described Compositional acaricide is suitable for is selected from Oryza glutinosa, Semen Tritici aestivi, Fructus Hordei Vulgaris, Herba bromi japonici, Semen Maydiss, Sorghum vulgare Pers., Rhizoma Dioscoreae esculentae, Rhizoma Solani tuber osi, wood
Potato, Semen sojae atricolor, garden pea, Semen Viciae fabae, Semen Pisi sativi, Semen phaseoli radiati, Semen Phaseoli, Cotton Gossypii, silkworm and mulberry, Semen arachidis hypogaeae, Brassica campestris L, Semen Sesami, Helianthi, Radix Betae, Caulis Sacchari sinensis,
Coffee, cocoa, Radix Ginseng, Bulbus Fritillariae Uninbracteatae, rubber, Cortex cocois radiciss, oil, Folium Agaves Sisalanae, Nicotiana tabacum L., Fructus Lycopersici esculenti, Fructus Capsici, Radix Raphani, Fructus Cucumidis sativi, Chinese cabbage, Herba Apii graveolentis, squeezing
Dish, Herba Alii fistulosi, Bulbus Allii, Citrullus vulgariss, Fructus Melo, hami melon, Fructus Chaenomeliss, Fructus Mali pumilae, mandarin orange, peach tree, tea, wild vegetable, bamboo sprout, Flos lupuli (Flos Humuli Lupuli), Fructus Piperiss, perfume (or spice)
Any of several broadleaf plants, Fructus Caricae, Cymbidium ensifolium (L.) Sw., potted landscape；The demodicid mite evil that described Compositional acaricide is suitable for is selected from Tetranychidae, Tenuipalpidae, furan line demodicid mite, wart demodicid mite
Section, tetranychus telariuses belong to, the evil mite of Eriophyidae, and these evil mites are worldwide Agricultural Mites, forestry harmful mites, gardening evil mite and health evil
Demodicid mite.
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| CN106995420B (en) * | 2016-01-26 | 2019-05-31 | 南开大学 | A kind of thiadiazoles oxime ether methoxy base acrylate derivative and its preparation method and application |
| CN105622597B (en) * | 2016-01-26 | 2018-08-17 | 南开大学 | A kind of chloro isothiazole anabasine compound and its preparation method and application |
| CN106332702A (en) * | 2016-08-24 | 2017-01-18 | 文山苗乡三七科技有限公司 | Comprehensive prevention and treatment measures for radix notoginseng round spot disease |
| EA202191181A1 (en) * | 2018-10-31 | 2021-08-06 | Кумиай Кемикал Индастри Ко., Лтд. | METHOD FOR CONTROLLING DISEASES OF FINE CEREALS, SEEDS OF FINE CEREALS AND METHOD FOR REDUCING LOSSES FROM THE POSITION OF FINE CEREALS |
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| CN1029189C (en) * | 1990-09-20 | 1995-07-05 | 三井东压化学株式会社 | Isothiazolecarboxylic acid derivatives, rice blast control agents containing same as active ingredients, and rice blast control method applying control agents |
| WO1995026956A1 (en) * | 1994-04-01 | 1995-10-12 | Shionogi & Co., Ltd. | Oxime derivative and bactericide containing the same as active ingredient |
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