CN104644996A - Medicine composition for treating hyperplasia of mammary glands and application thereof - Google Patents
Medicine composition for treating hyperplasia of mammary glands and application thereof Download PDFInfo
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- CN104644996A CN104644996A CN201510041492.3A CN201510041492A CN104644996A CN 104644996 A CN104644996 A CN 104644996A CN 201510041492 A CN201510041492 A CN 201510041492A CN 104644996 A CN104644996 A CN 104644996A
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Abstract
The invention belongs to the technical field of medicines, and in particular relates to a medicine composition for treating hyperplasia of mammary glands and application thereof. The medicine composition comprises the following components: Angelica sinensis, taxillus chinensis, rhizoma curculiginis, longspur epimedium, herba cistanche, Morinda officinalis, leonurus, Thunberg Fritillary Bulb, dried orange peel, semen brassicae, rhizoma cyperi and cinnamon. The composition is a pure traditional Chinese medicine composition, the prescription is reasonable, the medicine is applied based on an overall analysis of the illness and the patient's condition, and has better treatment effect to hyperplasia of mammary glands, in particular disharmony of thoroughfare and conception vessels type hyperplasia of mammary glands.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of medical composition and its use for the treatment of cyclomastopathy.
Background technology
Cyclomastopathy is also known as mammary dysplasia, fibrocystic disease of breast, be a kind of disease of comprehensive various clinical disease, comprise mammoplasia's disease (mastalgia), adenosis of breast, cystic cyclomastopathy etc., its sickness rate is because being subject to the attention of medical circle in increasing trend year by year.Sick for Chong and Ren channel disorder type mastoproliferation, Chinese medicine is thought, rushes wantonly two arteries and veins and arises from uterus, behavior breast in its QI and blood, lower behavior warp, and punching is appointed with kidney phase and and gone.If suffer from a deficiency of the kidney, Chong and Ren channel disorder, QI and blood addiction is stagnant, ties to gather to form in breast.Chong and Ren channel disorder type mastoproliferation disease is more common in the people of ferritic weakness, and age of onset is usually comparatively large, now women's deficiency of kidney-QI, yin and yang imbalance.Use Chinese traditional treatment, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, can effectively reduce untoward reaction and side effect, have good Research Significance and clinical generalization value.
Summary of the invention
The invention provides a kind of new pharmaceutical composition for the treatment of cyclomastopathy, overcome the deficiency of Chinese and western medicine preparation in the past, have good curative effect to Chong and Ren channel disorder type mastoproliferation, and have no side effect.Described pharmaceutical composition is obtained by following raw material: Radix Angelicae Sinensis, Herba Taxilli, Rhizoma Curculiginis, Herba Epimedii, Herba Cistanches, Radix Morindae Officinalis, Herba Leonuri, Bulbus Fritillariae Thunbergii, Rhizoma Cyperi, Cortex Cinnamomi.
Preferably, described pharmaceutical composition also comprises Pericarpium Citri Reticulatae and Semen Sinapis Albae.
The technical scheme adopted for solving its technical problem is the pharmaceutical composition of described treatment cyclomastopathy, be made up of the medicine of following weight: Radix Angelicae Sinensis 15-20 part, Herba Taxilli 10-20 part, Rhizoma Curculiginis 10-20 part, Herba Epimedii 5-15 part, Herba Cistanches 15-25 part, Radix Morindae Officinalis 1-6 part, Herba Leonuri 1-8 part, Bulbus Fritillariae Thunbergii 5-10 part, Rhizoma Cyperi 5-10 part, Cortex Cinnamomi 1-6 part.
Preferably, described pharmaceutical composition also comprises the medicine of following weight: Pericarpium Citri Reticulatae 5-10 part and Semen Sinapis Albae 5-15 part.
Most preferred technique scheme of the present invention is, described pharmaceutical composition of the present invention, is obtained by the raw material of following weight portion: Radix Angelicae Sinensis 18 parts, Herba Taxilli 15 parts, Rhizoma Curculiginis 15 parts, Herba Epimedii 10 parts, Herba Cistanches 20 parts, Radix Morindae Officinalis 3 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Thunbergii 8 parts, Pericarpium Citri Reticulatae 8 parts, Semen Sinapis Albae 10 parts, Rhizoma Cyperi 8 parts, Cortex Cinnamomi 3 parts.
Present invention also offers the preparation method of described pharmaceutical composition, specifically comprise the steps: the water raw material Radix Angelicae Sinensis of above-mentioned weight portion, Herba Taxilli, Rhizoma Curculiginis, Herba Epimedii, Herba Cistanches, Radix Morindae Officinalis, Herba Leonuri, Bulbus Fritillariae Thunbergii, Pericarpium Citri Reticulatae, Semen Sinapis Albae, Rhizoma Cyperi, Cortex Cinnamomi being added 8 times amount of medical material gross weight, decoct twice, after each 2 hours, filter, filtrate is concentrated into thick paste, crushed after being dried after merging.
Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to use or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.Preferably, pharmaceutical composition of the present invention conveniently preparation technology be prepared into tablet or capsule.Described capsule is after being pulverized by active component and and adjuvant sodium alginate, MgCO
3, stearic acid crosses 80 mesh sieves, mix homogeneously, granulate with dry granulating machine, 20 mesh sieves carry out granulate, particles filledly in hard capsules, namely obtain this product by obtained.
The present invention also asks to protect aforementioned pharmaceutical compositions in the purposes of preparation treatment cyclomastopathy particularly in preparation treatment Chong and Ren channel disorder type mastoproliferation medicine.In clinical observation process, treatment group comes off 4 routine cases, and matched group comes off 5 routine cases, and this 9 routine patient is all improvement backed off after randoms, and effectively to add up curative effect, all the other all complete clinical observation.Treatment group efficacy result is as follows: clinical cure 9 example (15.0%), effective 32 examples (53.3%), effective 15 examples (25.0%), invalid 4 examples (6.7%), total effective rate 93.3%; Matched group clinical cure 3 example (5.0%), effective 20 examples (33.3%), effective 24 examples (40.0%), invalid 13 examples (21.7%), total effective rate 78.3%.Between two groups, total effective rate compares, and treatment group is apparently higher than matched group.In treatment group therapeutic process, vital sign steadily and without serious adverse reactions such as allergy, treatment terminates rear lab index routine blood test, routine urinalysis etc. to the routine patient for the treatment of group 60 and carries out statistical procedures, shows no obvious abnormalities.Result shows that the clinical application of we is safely and effectively, and relapse rate is low, is worth studying and applying further.
Further, pharmaceutical composition of the present invention, described Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Herba Taxilli, bitter, sweet, flat.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.
Rhizoma Curculiginis, pungent, heat; Poisonous.Return kidney,liver,spleen warp.Kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.For sexual impotence cold sperm, muscles and bones flaccidity is soft, the cold numbness of waist knee joint, yang deficiency cold diarrhea.
Herba Epimedii, acrid, sweet, warm.Return liver, kidney channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Can be used for impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Herba Cistanches, sweet, salty, temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.
Radix Morindae Officinalis, sweet, pungent, tepor.Return kidney, Liver Channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Herba Leonuri, bitter, pungent, be slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Bulbus Fritillariae Thunbergii is bitter, cold.Return lung, heart channel.Heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing, for wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.
Rhizoma Cyperi, pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Cortex Cinnamomi, pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Pericarpium Citri Reticulatae, bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Semen Sinapis Albae, pungent; Temperature.Lung; Liver; Spleen; Stomach; Pericardium channel.Reduce phlegm by drink; Mass dissipating and swelling eliminating.Main cough with asthma abundant expectoration; Fullness in the chest and hypochondriac pain; Numb limbs and tense tendons; Arthralgia; Multiple abscess caused by damp-phlegm; Carbuncle of yin nature toxic swelling.
Bulbus Fritillariae Thunbergii preventing phlegm from forming and stopping coughing in side of the present invention, heat clearing away eliminating stagnation; Herba Taxilli, Yin Yang Huo ﹑ Rhizoma Curculiginis, Herba Cistanches, Radix Morindae Officinalis kidney-replenishing, bone and muscle strengthening; Rhizoma Cyperi dispersing the stagnated live-QI to relieve the stagnation of QI, the Semen Sinapis Albae of hard masses softening and resolving, the Pericarpium Citri Reticulatae of activating QI to eliminate phlegm eliminating stagnation; Radix Angelicae Sinensis, Herba Leonuri promoting blood flow to regulate menstruation, Cortex Cinnamomi dispersing cold for relieving pain.Pharmaceutical composition reasonable recipe of the present invention, all medicines share, can nourishing the liver and kidney, regulate that punching is appointed, blood circulation promoting and dispersing pathogen accumulation, the size of the sick lump of Chong and Ren channel disorder type mastoproliferation and pain are had clear improvement.Through clinical practice checking, its determined curative effect, mild in medicine property and, do not occur toxic and side effects and untoward reaction, safety coefficient is high, clinical observation total effective rate nearly 95%.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
The each raw material of the present invention is taken: Radix Angelicae Sinensis 18 parts, Herba Taxilli 15 parts, Rhizoma Curculiginis 15 parts, Herba Epimedii 10 parts, Herba Cistanches 20 parts, Radix Morindae Officinalis 3 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Thunbergii 8 parts, Pericarpium Citri Reticulatae 8 parts, Semen Sinapis Albae 10 parts, Rhizoma Cyperi 8 parts, Cortex Cinnamomi 3 parts by following weight portion.
Preparation technology is as follows:
After the raw material Radix Angelicae Sinensis of above-mentioned weight portion, Herba Taxilli, Rhizoma Curculiginis, Herba Epimedii, Herba Cistanches, Radix Morindae Officinalis, Herba Leonuri, Bulbus Fritillariae Thunbergii, Pericarpium Citri Reticulatae, Semen Sinapis Albae, Rhizoma Cyperi, Cortex Cinnamomi are pulverized respectively, add the water of 8 times amount of medical material gross weight, decoct twice, after each 2 hours, filter, filtrate is concentrated into thick paste, crushed after being dried after merging.Those skilled in the art directly can be used as medicine and be used or on this active component basis and appropriate amount of auxiliary materials sodium alginate, MgCO
3, stearic acid crosses 80 mesh sieves, mix homogeneously, granulate with dry granulating machine, 20 mesh sieves carry out granulate, particles filledly in hard capsules, namely obtain this product by obtained.
When using medicine composite for curing cyclomastopathy of the present invention, take prepared capsule, containing crude drug amount 0.4g, every day 3 times, each 3, take half an hour after meal for every.
Embodiment 2
The each raw material of the present invention is taken: Radix Angelicae Sinensis 15 parts, Herba Taxilli 10 parts, Rhizoma Curculiginis 10 parts, Herba Epimedii 5 parts, Herba Cistanches 15 parts, Radix Morindae Officinalis 1 part, Herba Leonuri 1 part, Bulbus Fritillariae Thunbergii 5 parts, Pericarpium Citri Reticulatae 5 parts, Semen Sinapis Albae 5 parts, Rhizoma Cyperi 5 parts, Cortex Cinnamomi 1 part by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 3
The each raw material of the present invention is taken: Radix Angelicae Sinensis 20 parts, Herba Taxilli 20 parts, Rhizoma Curculiginis 20 parts, Herba Epimedii 15 parts, Herba Cistanches 25 parts, Radix Morindae Officinalis 6 parts, Herba Leonuri 8 parts, Bulbus Fritillariae Thunbergii 10 parts, Pericarpium Citri Reticulatae 10 parts, Semen Sinapis Albae 15 parts, Rhizoma Cyperi 10 parts, Cortex Cinnamomi 6 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 4
The each raw material of the present invention is taken: Radix Angelicae Sinensis 15 parts, Herba Taxilli 10 parts, Rhizoma Curculiginis 20 parts, Herba Epimedii 15 parts, Herba Cistanches 15 parts, Radix Morindae Officinalis 6 parts, Herba Leonuri 8 parts, Bulbus Fritillariae Thunbergii 10 parts, Pericarpium Citri Reticulatae 10 parts, Semen Sinapis Albae 5 parts, Rhizoma Cyperi 10 parts, Cortex Cinnamomi 6 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 5
The each raw material of the present invention is taken: Radix Angelicae Sinensis 20 parts, Herba Taxilli 20 parts, Rhizoma Curculiginis 10 parts, Herba Epimedii 5 parts, Herba Cistanches 25 parts, Radix Morindae Officinalis 1 part, Herba Leonuri 1 part, Bulbus Fritillariae Thunbergii 5 parts, Pericarpium Citri Reticulatae 5 parts, Semen Sinapis Albae 15 parts, Rhizoma Cyperi 5 parts, Cortex Cinnamomi 1 part by following weight portion.
Preparation technology is with embodiment 1.
The clinical observation of embodiment 6 medicine composite for curing cyclomastopathy of the present invention
1, case-data: that selects hospital ward and outpatient clinic meets Chong and Ren channel disorder type mastoproliferation patient 120 example, is divided into treatment group, matched group at random.Wherein, treatment group: in 60 routine patients, the oldest 55 years old, minimum 35 years old, 44 years old mean age; Course of disease 1-5.Matched group: in 60 routine patients, the oldest 54 years old, minimum 35 years old, 45 years old mean age; Course of disease 1-4.5.The physical data there was no significant differences such as two groups of Genders, age, courses of disease, have comparability.
2, diagnosis basis:
(1) tcm diagnosis standard:
1) most have a flat lump at the outside upper quadrant of breast, and that lays one's hand on has the tough hard tubercle of beans size, can have tenderness.Lump border owes clear, with surrounding tissue adhesion.;
2) breast can have distending pain, the often growth and decline with susceptible to anger, and the moon of being everlasting is premenstrual to be increased the weight of, and alleviates after menstruation;
3) molybdenum palladium x-ray breast is taken the photograph sheet, cold light source strong illumination, liquid crystal thermography picture etc. inspections and is helped diagnosis.Make histopathological examination if desired.
(2) Chong and Ren channel disorder disease CM syndrome differentiation criterion: be more common in middle-aged women.The lump in breast moon is premenstrual to be increased the weight of, through after extenuate.Weak with the soreness of waist, tired, menstruation is imbalance successively, and the few color of amount is light, or amenorrhea.Light red tongue, tongue is white, deep-thready pulse.
(3) Western medicine diagnose standard
1) 35-55 year young women is apt to occur in.
2) symptom: breast has weight distending pain in various degree, twinge, tractive pain or dull pain, and can involve side or bilateral breast, pain, in periodically, changes with menstrual cycle or emotion changes.Some pain is irregular uncorrelated with menstrual cycle, or some is without pain.
3) sign: one or both sides breast can touch single or multiplely to differ in size, form is irregular, matter is tough, obscure boundary lump, has tenderness.Be apt to occur in outside upper quadrant, also dispersible in whole breast breast.Lump is graininess, nodositas, streak or lamellar, not of uniform size, and not etc., obscure boundary, with skin adhesion for soft or hard.
4) nipple discharge: discharge or when touching by certain latex dust system voluntarily, can cause nipple discharge, mostly be white or yellow green, or in slurry.
5) mammary gland color ultrasound is super checks: mammary gland tissue thickens, and fills the air distribution, differs in size, opaque dark area of fluid, and rounded or oval, cyst wall is smooth, and ventilative sound is good, the interstitial Echoenhance between capsule.
6) mammary gland molybdenum palladium x-ray takes the photograph sheet: visible mammary gland presents comparatively uniform density and increases shade, can occur at a quadrant or multiple quadrant.
7) pathological diagnosis: typical cystic hyperplasia of breast pathological change.
3, case standard is included in:
(1) age 35-55 year, women;
(2) in meeting, Western medicine diagnose standard and syndrome CM syndrome differentiation criterion;
Drug therapy is not carried out in (3) 3 months;
(4) clinical observation " Informed Consent Form " is signed.
4, Excluded cases standard:
(1) clinical observation " Informed Consent Form " is not signed;
(2) gestation or women breast-feeding their children;
(3) drug allergy or can not resistance to receptor is used to this research;
(4) the severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system are associated with, psychotic;
(5) breast tumor is merged, mastitis or other mastopathy person;
(6) age is below 35 years old or more than 55 years old person.
5, case standard is rejected:
(1) rear discovery is included in exclusion standard disease patient;
(2) case of medication is not specified by testing program;
(3) drug administration process data logging is incomplete, cannot judge curative effect person.
6, to come off and termination criteria:
(1) observe in patient exit voluntarily, person lost to follow-up;
(2) there is the person that should not continue reception test such as complication or special physiological change in experimenter;
(3) serious adverse reaction occurs person in test, should stop clinical trial in time.
Come off and answer itemized record reason with the case stopped, and the switching of its last curative effect testing result is added up for final result.
7, usage and dosage:
Treatment group: take medicine composite for curing of the present invention, capsule prepared by Example 1, every containing crude drug amount 0.4g, every day 3 times, each 3, after meal half an hour warm water delivery service.
Matched group: Yougui Wan, the kidney-Yang-Reinforcing Bolus (the accurate word Z11021040 of traditional Chinese medicines, the heavy 9g big honeyed pills of every ball; Every 100 heavy 10g water-honeyed pills) oral.1 ball, 3 times on the one.
A menstrual cycle is a course for the treatment of, and serve on two courses for the treatment of, menstrual phase is withdrawn.
8, curative effect determinate standard:
(1) cure: mastalgia is eliminated, lump in breast disappears;
(2) effective: mastalgia disappears, lump in breast disappearance > 1/2;
(3) effective: mastalgia alleviates, mass reduction > 1/3;
(4) invalid: mastalgia does not alleviate, lump in breast is unchanged or increase.
9, therapeutic effect:
In clinical observation process, treatment group comes off 4 routine cases, and matched group comes off 5 routine cases, and this 9 routine patient is all improvement backed off after randoms, and effectively to add up curative effect, all the other all complete clinical observation.Treatment group efficacy result is as follows: clinical cure 9 example (15.0%), effective 32 examples (53.3%), effective 15 examples (25.0%), invalid 4 examples (6.7%), total effective rate 93.3%; Matched group clinical cure 3 example (5.0%), effective 20 examples (33.3%), effective 24 examples (40.0%), invalid 13 examples (21.7%), total effective rate 78.3%.Between two groups, total effective rate compares, and treatment group is apparently higher than matched group.
In treatment group therapeutic process, vital sign steadily and without serious adverse reactions such as allergy, treatment terminates rear lab index routine blood test, routine urinalysis etc. to the routine patient for the treatment of group 60 and carries out statistical procedures, shows no obvious abnormalities.Result shows that the clinical application of we is safely and effectively, and relapse rate is low, is worth studying and applying further.
Claims (6)
1. treat the pharmaceutical composition of cyclomastopathy for one kind, it is characterized in that, its raw material primarily of following weight portion obtains: Radix Angelicae Sinensis 15-20 part, Herba Taxilli 10-20 part, Rhizoma Curculiginis 10-20 part, Herba Epimedii 5-15 part, Herba Cistanches 15-25 part, Radix Morindae Officinalis 1-6 part, Herba Leonuri 1-8 part, Bulbus Fritillariae Thunbergii 5-10 part, Rhizoma Cyperi 5-10 part, Cortex Cinnamomi 1-6 part.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, described pharmaceutical composition also comprises Pericarpium Citri Reticulatae 5-10 part and Semen Sinapis Albae 5-15 part.
3. pharmaceutical composition as claimed in claim 2, is characterized in that, its raw material primarily of following weight portion obtains: Radix Angelicae Sinensis 18 parts, Herba Taxilli 15 parts, Rhizoma Curculiginis 15 parts, Herba Epimedii 10 parts, Herba Cistanches 20 parts, Radix Morindae Officinalis 3 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Thunbergii 8 parts, Pericarpium Citri Reticulatae 8 parts, Semen Sinapis Albae 10 parts, Rhizoma Cyperi 8 parts, Cortex Cinnamomi 3 parts.
4. the pharmaceutical composition as described in as arbitrary in claim 1-3, it is characterized in that, described pharmaceutical composition is oral formulations.
5. pharmaceutical composition as claimed in claim 4, it is characterized in that, described oral formulations is tablet or capsule.
6. the purposes of the pharmaceutical composition as described in as arbitrary in claim 1-3 in preparation treatment Chong and Ren channel disorder type mastoproliferation medicine.
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| CN201510041492.3A CN104644996A (en) | 2015-01-27 | 2015-01-27 | Medicine composition for treating hyperplasia of mammary glands and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816607A (en) * | 2016-04-18 | 2016-08-03 | 张瑞武 | Traditional Chinese medicinal composition for treating breast hyperplasia and preparation method thereof |
| CN117298239A (en) * | 2023-10-12 | 2023-12-29 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Pure natural plant herbal mammary gland dredging essence liquid |
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| CN101024058A (en) * | 2006-02-23 | 2007-08-29 | 杨国银 | Medicine composition for treating hyperplasia of mammary glands |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101024058A (en) * | 2006-02-23 | 2007-08-29 | 杨国银 | Medicine composition for treating hyperplasia of mammary glands |
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| 安泽余: "中医药治疗乳腺增生病临床研究进展", 《河北中医》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105816607A (en) * | 2016-04-18 | 2016-08-03 | 张瑞武 | Traditional Chinese medicinal composition for treating breast hyperplasia and preparation method thereof |
| CN117298239A (en) * | 2023-10-12 | 2023-12-29 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Pure natural plant herbal mammary gland dredging essence liquid |
| CN117298239B (en) * | 2023-10-12 | 2024-08-30 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Plant herbal mammary gland dredging essence liquid |
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