CN104640604A - High porosity cellulosic sponge - Google Patents
High porosity cellulosic sponge Download PDFInfo
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- CN104640604A CN104640604A CN201380028037.9A CN201380028037A CN104640604A CN 104640604 A CN104640604 A CN 104640604A CN 201380028037 A CN201380028037 A CN 201380028037A CN 104640604 A CN104640604 A CN 104640604A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/729—Agar; Agarose; Agaropectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Abstract
The present invention provides compositions, devices, and methods for affecting, among other things, weight loss and/or weight control, by sequestering nutrients or other compounds such as toxins from absorption in the digestive tract. The compositions, devices, and methods employ one or more members made of a compressible, absorbent matrix material. In various embodiments, the matrix material is suitable for routine use. The compressible absorbent matrix material has a size, shape and/or geometry configured for efficient packing into a small space, and/or configured to absorb and substantially retain digested material in the stomach. The devices and compositions may further comprise one or more hydrogel(s), soluble or insoluble fibers, waxes, and/or gums to provide the desired mechanical properties and/or absorptive or shielding properties.
Description
Related application
This application claims the U.S. Patent application No.13/841 submitted on March 15th, 2013,138 and the U.S. Provisional Application No.61/616 that submits on March 27th, 2012, the priority of 037, its disclosure is incorporated to herein by reference.
Technical field
The present invention relates to device, compositions and method, it is for reducing from the nutrient of food absorption taken in or the amount of other compounds in gastrointestinal tract (GI track), and other purposes.
Background technology
Term " overweight " refers to the body weight higher than normal range.Overweight and obesity disease by calculate Body Mass Index (BMI) determine, BMI be in order to kilogram metering body weight divided by with the height of meter Ji Liang square.The overweight BMI that is usually defined by is 25kg/m
2to 29.9kg/m
2, obesity is defined by BMI>=30kg/m usually
2, and serious fatness is defined by BMI>=40kg/m usually
2(or under the existence of other medical science coexisting diseases BMI>=35kg/m
2).BMI is less than about 22.0kg/m
2desirable, although this may be difficulty and perhaps be unpractical target for many individualities.
Overweight and obesity disease becomes worldwide healthy epidemic diseases along with day by day popularizing.The data collected by 2007 based on Center for Disease Control (CDC) and NIH, in the U.S., the American more than 2/3rds is overweight and the American of 26% to 55% fat.In the world, Overweight and obesity disease affects developed country and developing country simultaneously.Such as, be fat at the population of Britain about 23%, by contrast, be about 11% to 23% in Mexico, be about 30% to 40% in South Africa, and be about 10% in Pakistan.
Overweight and obesity disease is relevant to many health risks, comprises type 2 diabetes mellitus, hypertension, dyslipidemia, coronary heart disease, cancer and apoplexy etc., and premature death.Compared with the individuality of normal type, BMI is 26.5kg/m
2to 29.9kg/m
2relevant mortality risk is increased to 1.5 times.BMI>=30kg/m
2the mortality risk of a variety of causes of those individualities be increased to 2 to 3 times.Economic implications is very large; The cost of the Overweight and obesity disease of the publication citation U.S. of Brookings Institution (Brookings institute) is annual at least 1,470 hundred million dollars.From the visual angle of medical science and economics, slimming argument is all clearly.
At present, can be used for slimming method and comprise behavior modification (metatrophia and exercise therapy), Drug therapy and fat surgical operation.By means of only going on a diet and tempering the needs of patients Drug therapy of object of failing to realize to lose weight.The FDA approved medicines of two classes clearly for losing weight.Sympathomimetic drug (such as, phendimetrazine, diethylpropion, phentermine (phentermine)) stimulates the release of norepinephrine and/or suppresses its re uptake in teleneuron.Draw an analogy, this effect is similar to caffeine, but the effect produced than caffeine is much better than.Sympathomimetic not only causes appetite inhibiting but also can cause hypertension and potential myocardial infarction, and therefore FDA restriction uses < 12 weeks to it.Ephedrine is the one of this apoplexy due to endogenous wind, and it exits from the market because of these adverse side effects recently.
Malabsorption medicine is the another kind of medicine of FDA approval for obesity.Orlistat (orlistat) is unique representative of this kind of medicine.Orlistat changes fat digestion by suppressing pancreatic lipase, causes 30% institute to absorb fatty malabsorption.This fat excretion in feces, instead of by body absorption.Orlistat be uniquely obtain FDA approval can for a long time for the medicine (up to 4 years) of obesity.
For the patient suffering from serious fatness, the unique confirmed mechanism that long term weight alleviates is bariatric surgery.Bariatric surgery is affected by malabsorption and/or restriction and loses weight.Malabsorption (orlistat as above) refers to feeding incomplete absorption.Health does not absorb the calorie of the whole amount be present in meals or given food.Restriction refers to the size reducing stomach, thus produces early stage satiety and reduce food consumption.
The Overweight and obesity patient not meeting the BMI standard of serious fatness will not perform the operation as the feasible selection lost weight, because be usually limited to severe obesity for the Insurance coverage of these programs.Therefore, Overweight and obesity patient a kind of FDA only can be used to permit for slimming medicine.Therefore, for the needs lost weight and the existence of body weight control succedaneum is very large.
Summary of the invention
The invention provides compositions, apparatus and method, its by make nutrient or other compounds (such as, ethanol or toxin) isolation and the absorption avoided in digestive tract affect lose weight and/or body weight control and other in.In numerous embodiments, use the compositions of compressible absorption bases material, apparatus and method are suitable for conventional use.
In an aspect, the invention provides a kind of device or compositions, it comprises to be designed for and to absorb in digestive tract and substantially the retain nutrient substance component of one or more compressible absorption bases material of---being such as present in the nutrient substance in stomach after a meal---.Device or compositions can use one or more of hydrogel, solubility or insoluble fibre, wax and/or natural gum further, to provide the mechanical performance of expectation and/or absorption or shielding properties, as described in detail herein.In some embodiments, device is the form of capsule, and it comprises can be the host material component of tubular form.Alternatively, device or compositions can be food additives.
In one aspect of the method, the invention provides one for absorbing and retaining (such as, shielding) from the nutrient of digestive tract Absorption or the method for other compounds.The method comprise be provided in feed before, feed during or feed posterior phraynx under device or capsule.Object can be object that is overweight or obesity, and said composition or device can lose weight for impact routinely.Alternatively, object such as can need the object of body weight control for normal type due to form or fat history.
In numerous embodiments, the oral device swallowed or compositions comprise " sponge " or " spongy pipe " of one or more compression or densifie state, and it is once enter in gastrointestinal tract and will expand.Spongy substrate or shelf structure (scaffolding) greatly expand the volume of displacement in the expansion process of sponge.Such as, in some embodiments, the fluid of spongy material self Absorbable rod ten times or more times himself weight, this contributes to material forming is shelf structure.When sponge is expanded, it not only absorbs ten times of its volumes, but is immersed in all fluids be contained in the void space of shelf structure.In other words, " chamber " or " hole " of sponge considerably increases the volume of institute's absorption fluids.Then these fluids then will be retained in the inside of sponge shelf structure by the hydrogel in the sponge cell-wall in each chamber of sealing.
More particularly, sponge absorbs a part of chyme float in stomach, thus reduces the amount carrying out absorbing obtainable food in small intestinal.In like fashion, calorie and health " isolation ", facilitate and lose weight.This device or compositions design make ability and/or the maximizing efficiency and avoiding and the side effect relevant based on the treatment of medicine for obesity of nutritious compound absorption (with the isolation of adjoint nutrient).Such as, the geometry of material and/or host material and one or more of hydrogel, solubility and/or insoluble fibre, wax and/or natural gum together provide the mechanical performance of expectation, comprise the efficient packaging of host material and the elasticity of expectation and/or expansion character, and expect to nutraceutical absorption with subsequently to the performance of the isolation and shield of Digestion.
In numerous embodiments, the present invention contributes to reversing in food industry the fiber reduced gradually in food and the trend replaced with sugar.The present invention is therefore also for diet provides the absorption that fiber eliminates sugar simultaneously.
In numerous embodiments, the present invention absorbs the fluid being rich in sugar and/or ethanol, and this sugar and/or ethanol are normally solvable, and therefore, the nutrient lower than other solubilities is easier by gastrointestinal absorption.In addition, sugar and/or ethanol may not benefit health.These fluids then may be combined thing and device isolation subsequently under it is in native state and/or gel state or viscous liquid state.Such as, this fluid is by absorption, reaction or as next isolated in soluble fiber combines with other compounds.Therefore, health will " be seen " (such as, can absorb between the period of digestion) less nutrient (such as, sugar, carbohydrate, fat, ethanol and ethanol etc.), and in contrast, more useful fiber " will be seen ".
In numerous embodiments, the invention provides under one's belt or in gastrointestinal tract, isolate compound, liquid (such as ethanol), medicine or other the dangerous or noxious substances being ready or being ingested unwillingly.Said composition or device have and absorb and suck institute and absorb material and make its gel also safely and naturally by potentiality that it removes in body.
In numerous embodiments, the invention provides nutraceutical isolation, and do not change individual normal diet, well-balanced flavour and by ordinary consumer feeding amount commonly in an efficient way.
Device of the present invention and compositions can be lost weight for lasting routinely or chronically by Overweight and obesity person, or are used for body weight control by the individuality of standard body weight.Such as, this device can use weekly once to two ten times, uses 1 year or the several years (such as, 1,2,3 year or more year).This device can use 1 to 3 time (such as, often using during meal) every day, uses 1,2 or 3 year or more year.Alternatively, it can may be wished the individual short-period used of the standard body weight of the laissez-faire calorie " injury " brought reducing them by excessive diet.Therefore, these apparatus and method can be the obesity of several hundred million people in world wide and overweightly provide solution that is cheap, safety, deposit in disease, life-span, health care cost and global economy burden and bring corresponding interests thereupon in relevant medical science.
This device and compositions can be used for the digestion or the biological effect that absorb and stop toxin or the alcohol be ready or be ingested unwillingly.In these embodiments, this device or compositions need not be used routinely, but can take together with having the food of the risk comprising toxin, or take based on the knowledge of contratoxin picked-up, or can be used for the impact of avoiding or resisting luxus consumption ethanol.
Accompanying drawing explanation
Fig. 1 to Figure 16 illustrates the exemplary design for absorbent material.
Figure 17 to Figure 20 illustrates exemplary absorbent material.
Figure 21 to Figure 26 illustrates other exemplary design for device of the present invention.
Detailed description of the invention
The invention provides compositions, apparatus and method, it avoids affecting from the absorption digestive tract losing weight and/or body weight control etc. by making nutrient or other compounds (such as toxin) isolation.Said composition, apparatus and method use one or more component be made up of compressible absorption bases material.In numerous embodiments, this host material is applicable to conventional application.This compressible absorption bases material has and is configured to be packaged into efficiently in little space and/or is configured to absorb under one's belt and basic size, shape and/or the geometry retaining material through digestion.This device and compositions also can comprise one or more of hydrogel, solubility or insoluble fibre, wax and/or natural gum, to provide the mechanical performance of expectation and/or absorption or shielding properties.
Said composition and device decrease the nutraceutical calorie absorption of intake body.The operational approach of this device can be called " malabsorption ", wherein nutrient is absorbed by host material (such as, spongy material) and isolates in the gastrointestinal tract.Therefore, segregate nutrient not by intestinal metabolism or absorption, and is drained together with host material.This device is inertia and passively works and substantially do not disturb body metabolism, in fact, and the nutrient that absorbs with the Absorption of other digestion activities from intestinal villi of this device " shielding ".
In some embodiments, compressible absorption bases material can be spongy material, and can be the form of " spongy pipe " and/or " sponge drop ".Although pipe can be simple shape the most directly perceived for host material, host material can be or may not be the shape of pipe, because other geometries will be suitable and/or favourable in some embodiments.Such as, determine shape by mechanically sponge being ground to form fritter to produce without any and be erose sponge sheet unique separately each other, it can be suitable and/or favourable in some embodiments.The surface configuration comprising volume ratio sponge in sponge is even more important.
Spongy material can be naturally occurring material can be maybe foamed artificial type sponge, and it comprises the space of multiple opening---can be such as opening irregular or regular in shape or closed " unit "---and limited by spongy substrate " cell-wall ".Spongy material can also be such material, space that is that it has rule or the irregular sky replaced and that close, its there is the geometry of restriction or amorphous space or restriction with the mixing of irregular or amorphous space.In some embodiments, spongy material has the structure designed geometrically can disintegrating (collapse) under machinery, chemistry or heat effect or its combination, and can present the shape of expansion subsequently, the shape of expansion can be the shape of original-shape (before compression) or another kind of expection.The shape expanded usually in response to the interaction of gastric content and/or with the chemical interaction being present in suitable additives in device after remove machinery, chemistry or heat effect and occur.
When host material is subject to mechanical compress, heat and/or chemical treatment (such as, by making materials chemistry modification, crosslinked (crosslinking), compound or covalent bonding compound etc.) time, its size and/or volume can be decreased to size much smaller than the volume of original unpressed size and/or expansion and/or volume.Compressible character allows multiple host material component efficient packet to load in little space, such as, for the capsule sent or other carriers.Such as, size or the volume of compression can be less than about 50% of dilation dimension, or in other embodiments, be less than about 40% of the size of expansion or volume, be less than about 30%, be less than about 25%, be less than about 20%, be less than about 15%, be less than about 10%, be less than about 5%, be less than about 1%, be less than about 0.5% or be less than about 0.1%.Usually, the mechanical compress applied in release or chemical restraint (such as, by chemical reaction, destruction, crosslinked etc.) or both after, material can present its initial larger shape.
The mechanism of the expansion of host material may be also elastic return, although wherein material also inelastic body itself, but after a period of time of compression and/or pressurization, still can have enough stiffness (such as, molecule creep time long enough) thus material still can present its original-shape at least in part.
Host material mechanically can be flattened and stacking or compress simply, to be then encapsulated in such as in the conventional medicine capsule swallowed.Host material is usually by can being compressed and can forming by the material elastic and/or with resilience of absorbing fluid and/or material in digestive tract.Host material has inner porosity usually as natural sponge.The unit of sponge or sponge-like material can be arbitrary and/or unbodied (the artificial or natural sponge such as, with usually commercially available is the same).Alternatively, in some embodiments, the unit of spongy material can be more regular and/or rule on geometry, as cellular or other geometries and/or volume arrangement.
Relative to the device comprising the amorphous of natural fiber and/or non-geometric structure, the geometry of host material also can provide to the expansion of this device and its digestible fluid absorbs and/or the amplification of hold facility and/or the effect of multiplication.Relative to amorphous device (such as, there is erose device), this amplification and/or multiplication effect can be at least 2 times, at least 5 times, at least 10 times, at least 50 times or at least 100 times.Therefore, these embodiments need this device or the compositions of much smaller quantity, quality, volume, dosage or amount.Such as, in some embodiments, user only needs to swallow piller or capsule (such as, the pill of stock size or capsule).With amplification as herein described and/or the effect of doubling consistent, this piller or capsule effectively can provide larger digestible fluid absorbability and therefore make it isolate or shield and avoid being crossed body absorption.
In some embodiments, that can be the routine produced by conventional method or the natural sponge of spongy material.In other embodiments, sponge-type materials can be produced by such as foaming agent, activating agent, penetrating agent, and by extrusion molding, blow molding, injection mo(u)lding, thermoforming, machinery or the formation such as chemistry engraving and shaping.Alternatively, spongy material can by by smaller fragment and/or geometry and/or the unit that is shaped arbitrarily be assembled into comparatively big unit and making, it allows carefully to select sponge like morphology.Such as, spongy material can pass through expressing technique, blow molding process, injection or the preparation of thermoforming moulding technology, or can mechanically and/or chemically die or mechanically engraving or formation.Spongy material can for partly or entirely elastic, elastomeric, be with or without resilience force, recoil or partially rigid or semirigid and/or plastics.Figure 17 to Figure 20 describes and is applicable to some exemplary spongy material of the present invention.
Usual selection spongy material makes cell-wall will have " shape memory ", and namely once make applied machinery and/or the release of chemical compression stress, then unit usually recovers at least in part or is expanded to its original size and/or shape.In some embodiments, spongy material can only expand due to the moisture absorption making host material expand and shrink, and is similar to because air is compressed into swelling (swelling) caused in expandable plastic matrix (such as expandable bounce-back room).
The expansion mechanism of institute's release spongy material can be that under the physiological condition such as making material be in stomach by the recovery of shape-memory material, (such as, at 37 DEG C) presents its original-shape at least in part.Elastomer or material with resilience can be used for spongy material such as elastomeric material as latex, guayule, polyurethane rubber, silicone rubber, cellulose, nano-cellulose, acrylonitrile-butadiene rubber or biomaterial such as elastin laminin, collagen and/or other native proteins, or after the time period extended, can maintain and preserve its original-shape under compression or return to shape memory or present any other suitable material difform.Alternatively, the mechanism that expands may be because the absorption of fluids of sponge to a great extent---such as, when comprising the material as hemicellulose with high-selenium corn power, and can sponge shelf structure be expanded hydrodynamic force.
Spongy substrate can be safe for people is swallowed material form.The example of suitable material comprises: the polymer of polyurethane, nylon, polyethylene, polypropylene, polyacrylate, EVA, natural rubber, silicon, silicone rubber, latex, EPDM rubber, n-butyl acetate rubber, acrylonitrile-butadiene rubber, PVA, PLA or copolymer.Suitable elastomeric biomaterials comprises silicones, thermoplastic elastomer (TPE), polyolefin and polydiene elastomer, poly-(vinyl chloride), natural rubber, Guayule rubber, Heparinized Polymers, hydrogel, polypeptide and elastomer, it can with other polymer or natural or artificial elastomer and/or filler as clay, starch, elastic fiber, elastic microfibers, elastic nano fiber mixing, and it can also mix with inertia and/or native compound such as cellulose and its derivant, elasticity and non-resilient filler and powder.
For substrate other suitable materials comprise natural polymer such as cellulose, nano-cellulose, Bacterial cellulose, cellulose fibre, microfibre and nanofiber, methylcellulose, ethyl cellulose, ethylmethylcellulose, other cellulose derivatives, with natural or synthesize or cellulose that syntheitic elastomers and/or filler mix and natural hydrogel (as chitosan), opuntia and other disaccharide and natural clay (such as Montmorillonitum).
In some embodiments, the spongy material of the character that all expectations are provided substantially can be used, such as swelling, absorb, soak, shielding, retain, disintegrate and biocompatible, biodegradable and only can comprise natural material.
In some embodiments, suitable sponge can by making undersized especially porous fiber element sponge generation carboxylation and being added into surperficial high hydrophilic functional groups---such as having COONa and COOK of the substitution value between 0.2 to 0.3---produces.
The disintegrate of host material is suitable or in the embodiment that shows in the gastrointestinal tract, can use biodegradable filler, compound or fiber.The part or all of disintegrate of these compounds, filler or fiber in digestive tract can induce partly or entirely disintegrating of spongy material.Therefore, by regulating the ratio of this additive to affect the Mean disintegration time of material.Exemplary filler can comprise starch and/or other polysaccharide.
The scope of the size of spongy substrate can be such as diameter for about 1nm to about 25mm, or about 1 μm to about 100 μm.The scope of the length of this spongy pipe can be such as about 1 μm to 3 ".Therefore, the geometry of this " pipe " can change according to selected width and length.In addition, the sponge of different size and shape can be used optionally to catch different particle size and/or suspension and/or colloid.Therefore, capsule can comprise the mixture of the sponge with multiple exterior geometry, spongy material, sponge form etc.
In addition, can select to make packaging or stacking maximizing efficiency to sponge geometry, or the quantity of compressible sponge in capsule is maximized, make the nutrient isolating power of each capsule maximize thus.
Said composition and device also can comprise other materials that are natural or synthesis with the absorption of the mechanical performance or expectation that provide expectation and/or shielding properties.
The fluid absorbed to prevent this device is released subsequently, and fluid is once namely absorption should be held in inside or be isolated in host material.In addition, should make to avoid being exposed to digestive enzyme through absorption fluids or material.Therefore, can make through absorption fluids gel or be prepared into and have more viscosity.Therefore by one or more of hydrogel, fiber and/or natural gum by the nutrient of catching sealing or be isolated from pipe.This hydrogel, fiber and/or natural gum directly can be bonded in spongy material, with sponge wall substrate and mix, to be contained in and/or to be scattered in sponge unit inner or be positioned at the specific region of pipe, such as, the entrance of pipe as herein described or opening part.
When not being subject to the restriction of mechanism of any particular theory or interpretation of scheme or effect, this device partly can work in the mode of the behavior being similar to dietary fiber in digestive system (such as, solubility and/or soluble fiber).In other words, compositions and device can reduce and/or slow down gastrointestinal tract Middle nutrition thing absorption and/or nutraceutical transmission can be promoted.Therefore, in some embodiments, compositions and device can comprise natural fiber as much as possible---solubility or insoluble or both combination.In some embodiments, the combination of solubility and insoluble fibre is used.Can comprise insoluble fibre to provide the mechanical performance expected especially as described herein, it comprises expansion and shielding.Also can comprise viscosity that is that insoluble fiber is captured for the adhesive properties (mucillagenic) of the gel of its fluid and/or increase, restriction, encapsulating or entrained fluid.
The limiting examples of suitable hydrogel comprises: polyvinyl alcohol, poly-(ethyl oxazoline), polyvinyl acetate-polyvinyl alcohol copolymer, poly-(2-2-(Acryloyloxy)ethanol), poly-(2-hydroxyethyl methylacrylate), carboxymethyl cellulose, polyacrylic acid and its copolymer, disaccharide, polysaccharide, chitosan, alginate, water soluble protein and Polynucleotide, natural clay (such as Montmorillonitum), sodium bentonite, absorbency fiber, superabsorbent fibers, microfibre and nanofiber, micron powder and nanometer powder combine with it.
Hydrogel in mixed sponge shape material and/or mucus and/or gummy compound form the unit of the caused sponge of compound, hole or wall to become permeability lower, and therefore can the turnover of suppression fluid after digestible fluid initial absorption or isolation.There are many different compounds realizing this effect---artificial and/or natural.Exemplary native compound can comprise water-soluble fibre, natural gum etc. as described above.Absorption Characteristics (profile) and/or other performances (such as, expansion character, absorbability, mechanical performance etc.) expected that expectation is provided can be selected to single hydrogel, natural gum or fibrous material or its mixture.
To be scattered in spongy substrate or to add to this place and one or more of hydrogels, fiber and/or the natural gum be mechanically contained in pipe or pipe unit can seal unit, thus the motion producing fluid (fiidds) can by the multiple sealing partially or completely limited or the compartment partly sealed, thus prevent absorbed nutrient from leaking or being permeated by digestive enzyme, because sponge will through <31 tract before excretion.One or more of hydrogels, fiber and/or natural gum in sponge cell-wall by swelling together with liquid until the expansion of sponge unit encloses axial hole wholly or in part.Another effect of one or more of hydrogel, fiber and/or natural gum can be make spongy pipe mechanically more stable or firm, so as to resist better in colon finally by time pipe just in case by situation about naturally excreting.
In some embodiments, nutrient is captured in sponge by one or more of hydrogel, fiber and/or natural gum, then sponge disintegrate after passing through upper gastro-intestinal tract.Such as, these components can occur maximum nutritious compound absorption gastrointestinal part after disintegrate, make it possible to not need mechanical stability.In this case, can carry out selection to spongy material makes material at least partly or all in the disintegrate of gastrointestinal bottom, with guarantee to remove pipe luxus consumption or clinically slowly enteral discharge the safety of (such as, avoiding the blocking of enteral) aspect.
In some embodiments, compositions and device comprise insoluble and water soluble dietary fiber, such as resistant starch, non-resistant starch and non-starch polysaccharides(nsp).Example comprises araboxylan, cellulose, dextrin, insulin, lignin, wax, chitin, colloid, beta glucan and oligosaccharide, and it comprises galactose and oligofructose.Other exemplary polysaccharide comprise polysaccharide hydrogen ethyl ester as pectin.Compositions and device can use the mixture of the mixture of different insoluble fibres, different soluble fiber and/or each mixture that is insoluble and soluble fiber one or more of.In some embodiments, the mixture of the fiber of two types (such as, insoluble and solubility) can be used.One or more of insoluble fibre can provide " sponge " skeleton and/or can provide function of shielding.
In some embodiments, compositions or device comprise the one or more of soluble fiber being selected from extracellular polysaccharide mucus.This extracellular polysaccharide mucus can from Aloe (Aloe vera), white Herba basellae rubrae (Baseila alba) (Herba basellae rubrae) (Malabar spinach), Radix et Caulis Opuntiae Dillenii, Chondrus crispus (Chondrus crispus) (Irish moss), Rhizoma Dioscoreae (Dioscorea opposita) (Rhizoma Dioscoreae, Chang Mount medicine), sun-dew (Drosera) (Herba Droserae Lunatae), Semen Trigonellae, Semen Lini, Sargassum (kelp), licorice (liquorice root), marshmallow, Verbascum, Abelmoschus esculentus, elargol Chrysanthemum (Parthenium), butterwort (Pingiucula) (butterwort), psyllium, Salvia hispanolum (Salvia hispanica) (Salvia Hispanica L.) seed, Elm (Ulmus) Cortex Myricae Rubrae (red elm) or any other suitable plant.
In these and other embodiments, compositions and device can comprise cellulose or cellulose derivative, such as methylcellulose, ethyl cellulose and/or methylethylcellulose.
In these and other embodiments, compositions and device can comprise natural gum, such as can available from Sargassum and other source those.Said composition comprises polyeletrolyte: agar (E406), alginic acid (E400) and sodium alginate (E401); With carrageenin (E407).The natural gum obtained from non-sea-plant resource comprises polyeletrolyte: the Radix Acaciae senegalis (E414) from the resin of wattle (Acacia tree), the gum ghatti from the resin of elm chloroxylon swietenia (Anogeissus tree), from the tragacantha shrub (E413) of the resin of Radix Astragali shrub (Astragalus shrub) and the POLY-karaya (E416) of resin from sterculia nobilis tree (Sterculia tree).Other natural gums comprise the guar gum (E412) from Guar beans, the carob (E410) from the seed of Ceratonia siliqua, the beta glucan from Herba bromi japonici or barley bran, the tunny gum available from popular feeling fruit tree, set from Dipterocarpaceae (Dipteroearpaceae) resin reach horse natural gum, glucomannan (E425), the gum mastic available from mastic shrub, chewing gum from Amorphophallus konjac plant.In some embodiments, mucus material comprises Semen Plantaginis (Psyllium) the seed shell from Plantago plant, the PiceameyeriRehd. Et Wils. natural gum from PiceameyeriRehd. Et Wils. tree, the natural gum that draws the tara gum of the seed of tree (E417) from tower and/or produced by bacterial fermentation, such as polyeletrolyte: gellan gum (E418) and xanthan gum (E415).Also animal fiber can be used, such as keratin (such as silk etc.), elastin laminin and/or collagen.These natural gums or fiber can available from commercial source.
One or more of hydrogel, fiber, wax and/or natural gum are by via such as providing the expansion that chemically expansible is host material to provide other mechanism (or power) via the absorption of water and other fluids.Such as, host material is inflatable or be present in the one or more of hydrogels of sponge cell-wall, fiber and/or gummy Absorbable rod water and fluid and make cell-wall hardening to make spongy pipe return to its original size and/or the shape at compression and/or heap prestack at least partly.
In some embodiments, device or compositions comprise independent or chemically with hemicellulose or the xylan of mechanical compound.This short chain polysaccharides (hemicellulose) is comparatively cheap and have very strong fluid absorbency.Such as, this device or compositions can comprise hemicellulose-citrate-chitosan, aerogel foam, be all elastic and have absorbability both it.In these and other embodiments, this device or compositions comprise or comprise further one or more of filler such as crystalline cellulose and/or amorphous cellulose, lignin or other hardening compounds.In this embodiment, the decompressor of substrate is built in the result being absorption of fluids in a way, and it can make the shelf structure material hardens of sponge and can expand entire expanse.
In some embodiments, compositions or device comprise the ester of hemicellulose and organic acid (such as, having carboxyl).Example comprises hemicellulose citrate, hemicellulose acetate and other organic acid, and it makes foam have flexibility and the elastic recoil of expectation.In other embodiments, compositions or device only comprise hemicellulose or hemicellulose and chitosan.Further, the embodiment of device or compositions can use starch-citrate-chitosan, starch-chitosan or starch-hemicellulose-chitosan.
In order to obtain the colloidization of expectation, when presence or absence hemicellulose-citrate-chitosan, other compound can be comprised.This compound comprises polytype cellulose or other compounds that is artificial and synthesis, such as one or more of: bovine serum albumin pectate, pectin-ethyl cellulose, Calcium Pectate and chitosan, naproxen colloid (naproxen pectin), de-esterification colloid, pectic acid gel of zinc, amylose, chondroitin sulfate (crosslinked or noncrosslinking), cyclodextrin, dextran, calcium alginate and alginate, locust bean gum, guar gum, glutaraldehyde and chloropropylene oxide.Such as, in some embodiments, employ guar gum, it can be mixed to or only be scattered in hemicellulose substrate foam sponge.
Another mechanism that host material expands can comprise the combination introducing compound and/or protein analogue matter or the structure arranged in the mode being similar to myoarchitecture, wherein shrink, expand and/or reverse a kind of component relative to another kind of component can cause rotating and/or reversing or expansion, thus cause the expansion of material.
Another mechanism discharging compressed host material can comprise the foaming and/or gas release agent that are activated by the heat of stomach and/or sour environment, and it can produce gas and/or foam to make material (such as, NaCO
3deng) expand.Similarly, when the sour environment of spongy material and stomach reacts, all or part spongy material can react with gastric acid, and it increases volume at least in part and makes sponge return to its original-shape.Usually, after the capsule (such as gelatine capsule etc.) comprising compressed material dissolves, be released to host material in stomach and usually expand and absorption fluids wherein at gastric.
But, another mechanism expanded can comprise the some parts of sponge and the electrostatic of other parts and/or magnetic repulsive force and/or captivation, or a pipe and another manage or be contained in pill or introduce the electrostatic interaction of the similar solid in stomach independently.In another embodiment, host material can be introduced with the distorted shape with elastic expansion mechanism as above, then it can untie and expand.
In some embodiments, nutraceutical catching also can by the distortion of host material (such as, winding as caramel) or rotate cause, in this case, host material can have flat geometric configuration, although this mechanism may have other shapes and can comprise the mechanism of absorption relevant to spongy material.Mentioned machine-processed one or combination can cause or induce this distortion and/or rotation above.
Host material can be columniform, and can have ellipse, avette, square, rectangle, triangle or polygon or trapezoidal cross section or shape.In addition, multiple rule or irregularly shaped or cross section can be used for forming compositions and device, and given " pipe " can comprise one of zone of dispersion of multiple special shape or cross section.Geometry and cross section can support that efficient packet loads in such as capsule, make " pipe " of q.s to be sent in little space.Geometry, cross section and hatch frame also can allow the efficient absorption of peptic digestion product.Geometry or the shape of mixing are also possible.Fig. 1 to Figure 16 describes many exemplary shape and cross section geometry.In addition, as shown, host material will have one or more axially open or aperture, although substantially all there is more than one aperture along on its any axle along its most major axis usually.Fig. 1 to Figure 16 shows multiple possible pore structure.
One or more hole can be placed in the middle or can off-center along the main shaft of pipe (such as, along the longest side).One or more hole can have circle, star, cross or other segmentation geometries (see Fig. 1 to Figure 16).The object in this hole is the quick absorption promoting stomach Middle nutrition thing.The sponge structure with hole is designed to promote to enter to and is trapped in the sponge of more large scale particle, otherwise may be absorbed into the inside of sponge.In addition, one or more hole reduces the volume of compressed pipe in capsule usually, therefore can hold more pipe in single capsule and single capsule or its can isolate the nutrient of more volume together with single pill.
In some embodiments, device or compositions can comprise one or more of releasing agent in one or more chamber or in the unit of sponge, so that the adhesion between the wall avoiding unit.This releasing agent can be natural or artificial wax, the polymer of wax and elastic natural gum or only substratum, such as polyvinyl, or Polyethylene Glycol, or only polyethylene.In some embodiments, releasing agent is dissolved in stomach or is natural foaming agent (such as, sodium bicarbonate).
The external surface layer of host material can be complete, smooth and without perforation or hole substantially, or can have the very little some holes of possibility in some embodiments.This all or part of complete top layer can avoid due to digestion in machinery and enzymatic catalysis cause absorb nutraceutical loss from host material.But in some embodiments, the outside of host material is substantially identical with inside and can be perforated.
Nutrient to be absorbed enters host material via opening usually, and described opening can be present in the end not having skin, or is located across the opening in hole of pipe.Can to sponge geometry and in sponge the number of pipe and position select to receive most probable number MPN object pipe at fixing capsule volume, thus guarantee, once pipe discharges from capsule, to recover most probable shape memory, maximize with the absorption of the combination making each pipe or these or other factor.
Host material is extruded by routine or is made after the shape expected in machine cuts by the foaming of material.Alternatively, host material can by tape punching press of advancing fast.Host material is encapsulated by mip rolls spongy material sheet.As conventional in pharmaceuticals industry, torrent can operate the film of packaging or protection compound.Such as, material can be PLA or other natural or artificial materials.Mip rolls compresses and cutting host material simultaneously, and roll around sponge die diaphragm seal.The die sponge that great majority these pair of film comprises is deposited in normal capsules gel cap or in other similar containers.Although a kind of similar technique---more miniaturization---can be used for manufacturing the prerequisite of sponge as food.By at main shelf structure material (such as, foam) in mechanically punching hole manufacture " spongy " substrate of shelf structure, and on itself after folding porose core unit material, rotate folding or gluing or mechanically fastening porose band thus keep three dimensional structure, and then compressed and encapsulate.Roller also can be designed to not only flatten sponge, but also provides transverse compression.
According to size, the present invention can use the encapsulating of host material, micron encapsulating or nanometer to encapsulate.These wrapper technologies are known, and such as micronutrient or drug delivery.In some embodiments, this device and compositions is encapsulated with casein.The technology of micron encapsulating or nanometer encapsulating comprises: pan coating, air suspension coating, spray-drying, ionotropy gel, cohesion, in-situ polymerization.In other embodiments, by freezing sponge of encapsulating compressive state.Once by compression and freezing, the spongy substrate with a small amount of water is compressed to allow to be easy to encapsulate by continuing.
When treated sponge is expanded form, sponge can such as mix to recompress sponge and make it be configured as wraps by granule with seasoning fat, and behaviour is carried out swallowing ready.
For losing weight or body weight control, described compositions or device before dining, period or swallow afterwards, or to be ingested in the such as period such as breakfast, fast food any other food intake time.By regulating capsule size, the number of pipe and the total absorptivity of capsule, capsule can especially for large or little size human body and/or less or many appetite and changing.Once swallow the capsule comprising such as " spongy pipe ", then capsule under one's belt or enteral dissolve with fully disposable or (such as, delay release) releasing tube in groups.No longer by capsule machinery or chemical restraint through releasing tube subsequently by expanding, absorbs, catch, close, immersion tube discharges a part of content of stomach existing for the moment or intestinal.
In some embodiments, compositions or device can be directly used in food the calorie content (such as mixed with food) to reduce the food comprising this device.Such as, this device can be disperseed, add and/or is mixed in food or as being used for being added in food product (such as, independent component in the food of pre-packaged, the food supplied in company with restaurant or with the food in consanguinity, in the beverage etc.) is included in packaged food.In one embodiment, this device (such as, capsule etc.) can be made to have certain scale or size makes this device to mix with prepared food or to be added into wherein.Such as, there is such as spherical or ellipsoid geometry be of a size of and be such as less than about 500 μm, be less than about 250 μm, be less than about 100 μm, be less than about 50 μm, be less than about 40 μm, be less than about 30 μm, be less than about 20 μm, be less than about 10 μm, be less than about 5 μm or be less than the little sponge " drop " of about 1 μm (or arbitrarily other values or scope or value wherein or the value lower than it) can at such as chocolate, coating, fruit jam, peanut butter, butter, corn, flour, sweet food, confection, cake, dough/pasta, pasta, sugar such as sucrose or fructose or high-fructose corn syrup, even soft drink or alcoholic beverage, fruit juice and/or any other for sell or at the restaurant in supply food on or within.
The small size of these capsules can allow it to avoid being destroyed during chewing, and it can be made not discovered by taste bud.Such as, compositions can be tasteless, and/or can be proportionally given it is provided level and smooth " mouthfeel ".Once enter in stomach, device or " drop " will discharge and then inflatable, absorption fluids from any encapsulating material, and in some embodiments apparatus design being become like this (such as, as described herein), fluid gel that is that make absorption or that encapsulate.
When the food needs comprising this device are cooked further and/or prepare (such as flour, dough etc.), can select to prevent from being exposed to heat and/or being exposed to cooking fluid to encapsulating material.This encapsulating can be subject to the impact of the material can resisting this heat and/or fluid exposure, but can degrade in the gastrointestinal tract or dissolve in addition.Such as, heat-resisting and/or heat stability can be selected, at normality pH fluid-resistant but the encapsulating material dissolved at sour environment (such as, under one's belt).Exemplary materials comprises polylactic acid (PLA), and it can resist the temperature up to 190 degrees Celsius.
Device and compositions can be used for the digestion or the biological agent that absorb and stop toxin or the ethanol be ready or be ingested unwillingly, in these embodiments, device or compositions need not use routinely, but can take together with having the food of the risk comprising toxin, or the knowledge according to contratoxin picked-up is taken, or can be used for the impact of avoiding or resisting luxus consumption ethanol.
Should understand and use term " isolation ", " shielding ", " comprising ", " avoiding assimilation " and similar term used herein not to mean absolute sense.In other words, effectiveness of the present invention is that device is for partly isolating and reducing/hinder the ability absorbed.
Following non-limiting example will illustrate many aspects of the present invention.Certainly, be to be understood that example only illustrates that some embodiment of the present invention is not construed as limiting scope of the present invention, scope of the present invention is limited by the claim appended by the ending of this description.
Example
In one example, commercially available pure cellulose sponge is obtained.Sponge is cut into less tubular form, and its diameter is about 3mm to 4mm, and length is about 1 inch.Then in carboxymethyl cellulose (CMC) powder (hydrogel), band is coated with.Then the band through hydrogel coating of cutting is inserted and have in polyethylene terephthalate (PET) pipe of about 6 μm of heavy walls (such as, the thickness of hair) and about 4mm to 5mm internal diameter.Prepare a collection of about 100 PET being filled with sponge to manage.
Then the PET pipe longitudinal arrangement of the such filling sponge of 20 bundle, compression inserting are about 25mm and diameter to be about in the gelatine capsule of 9mm and to form " pill ".Each pill is weighed as about 500mg.
Obtain commercially available canned chicken soup and be poured in plastic containers.Sugar, salt and Fructus Citri Limoniae juice are added in chicken soup simulate environment (such as, acidity) and the content of stomach after pickuping food.Then mixture is heated to the temperature of about 35 DEG C to about 40 DEG C.
Then prepare as mentioned above pill is inserted in mixture, and described mixture is stirred a few minutes.After about 2.5 minutes, gelatine capsule is dissolved and starts to discharge sponge.Swelling the sponge discharged by dissolving gel capsule.Continue stir about 10 minutes.
Then with filter sponge saturated for soup removed from mixture and weigh.Make this experiment repeat 4 times again, amount to 5 experiments.The gross weight of sponge is in the scope of about 13 grams to about 19 grams.
Spongy pipe has more rigidity after absorption soup mixture.Fluid mixture is made to enter in spongy unit, wherein by those fluids of CMC gel.Therefore, in exemplary experiment, sponge absorbs the soup mixture of about 18.5 grams from 0.5 gram of initial weight to 19 gram final weight.
Calorie content based on estimated soup mixture is about 4kcal/g, and consider dilute with water soup, calculate the nutrient that exemplary pill Absorbable rod is about 72Kcal, this will be isolated and avoid being absorbed in the gastrointestinal tract and metabolism.Therefore, such as, as described in 5 pills can isolate the nutrient of the little hamburger be equivalent to from user diet.Therefore, the people of companion food consumption about 5 exemplary pill can reduce by the body weight of about 15 pounds every year.
Further developing and improving of the packaging of spongy material as herein described, its geometry, the hydrogel used and sponge will improve this sponge significantly and comprise the calorie absorption ability of pill of this sponge.Such as, comprise by expand and sponge prepared by the spongy material absorbing about 100 times of its initial volumes there is about 2.5cm
3the sponge pill of volume can be caught up to about 250cm
3fluid.This volume (i.e. 250cm
3) be equivalent at least 250 grams of nutrients, and therefore can realize the calorie that each pill isolates about 1000kcal.
By described herein and be interpreted as explaination the present invention by the embodiment illustrated by aforementioned exemplary, and should not should be understood to restriction.On the contrary, present disclosure comprise as claims embody its alternative form and equivalents.
Claims (21)
1. a device, comprise one or more component of compressible absorption bases material, it has and is configured to be packaged into efficiently in little space and/or is configured to absorb under one's belt and basic size, shape and/or the geometry retaining material through digestion.
2. device as claimed in claim 1, wherein, described absorption bases material has the shape of restriction.
3. device as claimed in claim 1, wherein, described absorption bases material is pipe.
4. device as claimed in claim 3, wherein, described pipe comprises one or more internal cavities be connected with outside.
5. device as claimed in claim 4, wherein, described internal cavities has the shape of restriction.
6. device as claimed in claim 1, wherein, described host material comprises elastomer, latex, guayule, polyurethane rubber, silicone rubber, cellulose, nano-cellulose, acrylonitrile-butadiene rubber, elastin laminin, collagen or its combination.
7. device as claimed in claim 1, wherein, described device recovers its original shape after being compressed.
8. device as claimed in claim 1, it also comprises other compounds one or more of be selected from hydrogel, solubility or insoluble fibre, wax and natural gum or its mixture.
9. device as claimed in claim 8, wherein, described hydrogel comprises polyvinyl alcohol, poly-(ethyl oxazoline), polyvinyl acetate-polyvinyl alcohol copolymer, poly-(2-2-(Acryloyloxy)ethanol), poly-(2-hydroxyethyl methylacrylate), carboxymethyl cellulose, polyacrylic acid, acrylic copolymer, disaccharide, polysaccharide, chitosan, alginate, water soluble protein, Polynucleotide, natural clay, Montmorillonitum, sodium bentonite, absorbency fiber, superabsorbent fibers, microfibre, nanofiber, micron powder, nanometer powder and combination thereof.
10. device as claimed in claim 8, wherein, described device comprises extracellular polysaccharide mucus, cellulose, cellulose derivative, hemicellulose, keratin, elastin laminin, collagen and their mixture.
11. devices as claimed in claim 8, wherein, described device comprises agar, alginic acid, sodium alginate, carrageenin, Radix Acaciae senegalis, gum ghatti, tragacantha shrub (E413), POLY-karaya, guar gum, carob, beta glucan, tunny gum, reaches horse natural gum, glucomannan, frankincense gum, Semen Plantaginis seed shell, PiceameyeriRehd. Et Wils. natural gum, tara gum, gellan gum, xanthan gum and their mixture.
12. devices as claimed in claim 1, described device is suitable to safety for routine uses.
13. devices as claimed in claim 1, it has basic geometry as Suo Shi one of Fig. 1 to Figure 16 and Figure 21 to Figure 26.
14. devices as claimed in claim 1, wherein, described device is the form of capsule.
15. devices as claimed in claim 1, wherein, described device is through the gastrointestinal tract of object, and basic maintenance is perfect.
16. devices as claimed in claim 1, wherein, described device is dissolved in the gastrointestinal tract of object.
Isolate for making nutrient or compound and avoid in the systemic method of gastrointestinal tract for 17. 1 kinds, it comprises the device swallowed according to any one of claim 1 to 16.
18. 1 kinds of methods being used for the treatment of obesity, it object comprised to obesity provides the device according to any one of claim 1 to 16.
19. methods as described in claim 17 or 18, wherein, use described device routinely.
20. 1 kinds of Foods or drinkses, it comprises the device according to any one of claim 1 to 16.
21. 1 kinds of kit utilitys, it comprises the device according to any one of Foods or drinks and claim 1 to 16.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911305985.8A CN111494332A (en) | 2012-03-27 | 2013-03-15 | High porosity cellulose sponge |
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| US201261616037P | 2012-03-27 | 2012-03-27 | |
| US61/616,037 | 2012-03-27 | ||
| PCT/US2013/032513 WO2013148359A1 (en) | 2012-03-27 | 2013-03-15 | High porosity cellulosic sponge |
| US13/841,138 US20140276330A1 (en) | 2013-03-15 | 2013-03-15 | High porosity cellulosic sponge |
| US13/841,138 | 2013-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201911305985.8A Division CN111494332A (en) | 2012-03-27 | 2013-03-15 | High porosity cellulose sponge |
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| CN104640604A true CN104640604A (en) | 2015-05-20 |
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|---|---|---|---|
| CN201380028037.9A Pending CN104640604A (en) | 2012-03-27 | 2013-03-15 | High porosity cellulosic sponge |
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| Country | Link |
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| JP (1) | JP6230592B2 (en) |
| CN (1) | CN104640604A (en) |
| CA (1) | CA2868808A1 (en) |
| RU (1) | RU2662566C1 (en) |
| WO (1) | WO2013148359A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9220688B2 (en) | 2004-02-10 | 2015-12-29 | Slendine Sa | Device and method for reducing calorie intake |
| US9320715B2 (en) | 2011-03-29 | 2016-04-26 | Slendine Sa | Devices and methods for weight control and weight loss |
| CN107033392A (en) * | 2017-03-28 | 2017-08-11 | 常州大学 | A kind of high preparation method for receiving dirty cleaning sponge |
| CN110333588A (en) * | 2019-08-12 | 2019-10-15 | 程慧玲 | One kind communicating networked devices based on Internet of Things security key |
| CN110743513A (en) * | 2019-11-01 | 2020-02-04 | 浙江科技学院 | Preparation method of cellulose sponge for copper ion adsorption |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102523225B1 (en) | 2016-05-19 | 2023-04-18 | 디카피노,인크. | Caffeine-adsorbing substances, caffeine-adsorbing systems, decaffeination systems and related methods for removing caffeine from solutions |
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| WO2010110882A1 (en) * | 2009-03-23 | 2010-09-30 | Paolo Costa | Absorption barrier and method of using the same |
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| US20030072804A1 (en) * | 2001-03-19 | 2003-04-17 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
| EP1718279A2 (en) * | 2004-02-10 | 2006-11-08 | Itzhak Katz | Device and method for reducing calorie intake |
| JP2009523462A (en) * | 2006-01-23 | 2009-06-25 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | Methods for reducing animal food intake and controlling body weight |
| WO2009086119A2 (en) * | 2007-12-20 | 2009-07-09 | 7L, Llc | Swallowable self-expanding gastric space occupying device |
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| DE102008061536A1 (en) * | 2008-12-03 | 2010-06-10 | Aesculap Ag | Medical-technical absorbent body, in particular for the removal of wound fluids from human and / or animal body cavities |
| EP2482912B1 (en) * | 2009-09-30 | 2019-10-23 | Lohmann & Rauscher GmbH & Co. KG | Vacuum sponge drainage |
| US20110295299A1 (en) * | 2010-03-03 | 2011-12-01 | Gavin Braithwaite | Gastric volume filling construct |
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- 2013-03-15 WO PCT/US2013/032513 patent/WO2013148359A1/en active Application Filing
- 2013-03-15 CN CN201380028037.9A patent/CN104640604A/en active Pending
- 2013-03-15 CA CA2868808A patent/CA2868808A1/en not_active Abandoned
- 2013-03-15 RU RU2014143014A patent/RU2662566C1/en not_active IP Right Cessation
- 2013-03-15 JP JP2015503342A patent/JP6230592B2/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010110882A1 (en) * | 2009-03-23 | 2010-09-30 | Paolo Costa | Absorption barrier and method of using the same |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9220688B2 (en) | 2004-02-10 | 2015-12-29 | Slendine Sa | Device and method for reducing calorie intake |
| US9724306B2 (en) | 2004-02-10 | 2017-08-08 | Slendine Ag | Device and method for reducing calorie intake |
| US11786474B2 (en) | 2004-02-10 | 2023-10-17 | Biolumen Inc. | Device and method for reducing calorie intake |
| US9320715B2 (en) | 2011-03-29 | 2016-04-26 | Slendine Sa | Devices and methods for weight control and weight loss |
| CN107033392A (en) * | 2017-03-28 | 2017-08-11 | 常州大学 | A kind of high preparation method for receiving dirty cleaning sponge |
| CN110333588A (en) * | 2019-08-12 | 2019-10-15 | 程慧玲 | One kind communicating networked devices based on Internet of Things security key |
| CN110333588B (en) * | 2019-08-12 | 2020-09-29 | 深圳市承和润文化传播股份有限公司 | Internet of things-based security key communication networking equipment |
| CN110743513A (en) * | 2019-11-01 | 2020-02-04 | 浙江科技学院 | Preparation method of cellulose sponge for copper ion adsorption |
| CN110743513B (en) * | 2019-11-01 | 2022-06-14 | 浙江科技学院 | Preparation method of cellulose sponge for copper ion adsorption |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013148359A1 (en) | 2013-10-03 |
| JP2015515308A (en) | 2015-05-28 |
| CA2868808A1 (en) | 2013-10-03 |
| RU2662566C1 (en) | 2018-07-26 |
| JP6230592B2 (en) | 2017-11-15 |
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