CN1046315C - Multidose anaerobic indicator - Google Patents
Multidose anaerobic indicator Download PDFInfo
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- CN1046315C CN1046315C CN91108195A CN91108195A CN1046315C CN 1046315 C CN1046315 C CN 1046315C CN 91108195 A CN91108195 A CN 91108195A CN 91108195 A CN91108195 A CN 91108195A CN 1046315 C CN1046315 C CN 1046315C
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- icing sugar
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Abstract
The present invention relates to a multidose anaerobic indicator which is composed of color changing powdered sugar, a pH regulating agent, a reducing agent, a color developing agent and an excipient. Color developing reaction is sensitive, and the present invention can be made into products of liquid type, paper type, tablet type, etc., can be used for anaerobic culture, deoxidization seal and oxygen presence monitoring, and is the matching product of a dual-sucking seal storage agent for fresh preservation.
Description
The present invention proposes a kind of multi-form anaerobism indicator, can make the product of aqua, charta, three kinds of formulations of tablet on demand, the blue look of general demonstration during aerobic, the color that shows pink or other requirements during anaerobic can be used for that anaerobic bacteria culture, deoxygenation are sealed up for safekeeping, food product pack or other occasion aerobic whether monitorings.Be the auxiliary products of " dual-sucking seal-storage agent for fresh-keeping, its preparation method and use thereof " (Chinese invention patent CN1012561B).
Detecting at present aerobic whether indicator has common U.S. blue indicator (aqua), Japan's special clear JP61152299 blue oxygen indicator of disclosed methyl (tablet) etc., all is one-pack type, uses limitation, and ubiquity variable color sensitive issue not too.
The purpose of this invention is to provide anaerobism indicator a kind of variable color sensitivity, multi-form, can make aqua, charta, tablet on demand, both can be used for food product pack, can be used for anaerobic bacteria culture again.The present invention adopts module formulating of recipe thought for this reason, the indicator composition is divided into five relatively independent functional blocks---colour-changing agent, PH conditioning agent, developer, reductive agent, vehicle, based on colour-changing agent, difference (vehicle change) along with forming mode, suitably the correction work point is developed purpose to realize multi-form.
Purpose of the present invention can reach by following measure:
A kind of multi-form anaerobism indicator, form by colour-changing agent, PH conditioning agent, reductive agent, developer and several parts of vehicle, utilize in the variable color powder oxidation-reduction indicator composition oxidation state also ortho states show that the characteristic of different colours (show blue look, go back ortho states and become colourless as methyne orchid, quiet blue sulfonate oxidation state) is formulated, it is characterized in that:
1, contains the variable color Icing Sugar that carbohydrate and reversible oxidation-reduction indicator are made colour-changing agent;
2, the PH conditioning agent that contains basic metal, alkaline earth metal hydroxides or other bases;
3, contain with good grounds colour developing requirement and the developer matched;
4, based on the variable color Icing Sugar, can make the product of aqua, charta, three kinds of formulations of tablet, its weight is composed as follows:
The variable color Icing Sugar:
1 part of colour-changing agent
PH conditioning agent 1.6-5 part
Icing Sugar 240-560 part
Distilled water 10-20 part
Colour developing liquid:
1 part of developer
1 part of PH conditioning agent
Distilled water 800-4300 part
Form formula:
| Project name | Tablet | Charta | Aqua |
| The variable color Icing Sugar | 5-30 part | ||
| The PH conditioning agent | 0.5-12 part | ||
| Reductive agent | 0-15 part | ||
| Colour developing liquid | 0-30 part | ||
| Vehicle | 40-160 part | Adding distil water dilutes molten Jie | |
| Diluting condition | Charta---distilled water: the variable color powder=(40-200): 1 distilled water: colour developing liquid=(10-300): 1 aqua---distilled water: the variable color powder=(200-300): 1 distilled water: colour developing liquid=(100-850): 1 | ||
| Show Color | Show also ortho states color (when not adding developer) of developer color or colour-changing agent when showing colour-changing agent oxidation state color anaerobic during aerobic | ||
The variable color Icing Sugar is an indicator basal component, its aqueous solution is exactly a kind of anaerobism indicator, it is the alkaline mixt of a kind of carbohydrate (as glucose, fructose, sucrose, maltose, lactose etc.) and oxidation-reduction indicator, the most frequently used carbohydrate is a glucose, and the most frequently used variable color Icing Sugar is a glucose---methyne blue discoloration powder.The colour-changing agent that contains in the variable color powder is a kind of reversible oxidation-reduction indicator (as safranine fourth, phenol safranine, methyl orchid, methyne orchid, Diao Tianqing, quiet blue sulfonate, N-phenylanthranilic acid, a diphenylamine-sulfonate, ferrosin is ferrous, the nitro ferrosin is ferrous, to ethoxy chrysol etc.).Contain methyl orchid, quiet orchid---the indicator of colour-changing agents such as sulfonate, show blue look during aerobic, become colourless during anaerobic; Show redly when containing the indicator aerobic of Diao Tianqing colour-changing agent, show colourless during anaerobic; Show purple when containing the indicator aerobic of sodium diphenylaminesulfonate colour-changing agent, show colourless during anaerobic; Contain that ferrosin is ferrous, the indicator of the ferrous colour-changing agent of nitro ferrosin, show sky blue during aerobic, become red or the like during anaerobic.
The PH conditioning agent is that a kind of alkali (as basic metal, alkaline earth metal hydroxides or other bases) is used for the correction work point.
Developer can add in prescription and can not add, and depends primarily on the anaerobic state colour developing and requires and the colour-changing agent kind.When the colour-changing agent of selecting for use also ortho states show (as methyl orchid, methyne orchid, quiet orchid---sulfonate, N-phenylanthranilic acid, Diao Tianqing etc.) when colourless, consider to add developer, this moment, metachromasia did not take place in developer, only work to show anaerobic state indicator color, therefore, can be according to the colour developing requirement, choose the various metachromatic pigment, acid base indicator, dyestuff do not participated in and make developer, as select for use rose red b, orange beta-naphthol, phenol red, phenolphthalein or orchil to make developer, show red indicator in the time of can making anaerobic; Select for use bromothymol blue, nitrazine yellow, thymol blue, xylenol orchid etc. to make developer, show the indicator of blue look in the time of can making anaerobic.Commonly used is red developer.When colour-changing agent this when the reduction attitude can show certain color (the ferrous ortho states of going back of, nitro ferrosin ferrous as ferrosin shows red), can not add developer, this moment, the indicator color was determined by the colour-changing agent color.
Vehicle is the be shaped general name of required filler, binding agent, lubricant of compressing tablet, and the material that can be used as filler has the oxyhydroxide of aluminium, magnesium, beryllium, vitriol, carbonate, hydrophosphate, phosphoric acid salt, white bole etc.; The material that can make binding agent has starch, gelatin, gum arabic, carboxymethyl cellulose, Xylo-Mucine, ethyl cellulose, Macrogol 4000, Microcrystalline Cellulose polyvinyl alcohol etc.; The material that can make lubricant has hard acid ester salt, talcum powder, hard ester acid, aqueous paraffin wax, boric acid, differential silica gel etc.It consists of:
Filler: binding agent: lubricant=(20-80): (20-70): (1-3).
In case of necessity, also can add iron protochloride, dichloride copper, tin protochloride, zinc chloride or other strong reductants such as Cu, Sn in the prescription, Fe, Zn etc. make reductive agent.
The present invention has following advantage compared to existing technology:
This prescription has the color reaction sensitivity and (goes back ortho states and deaeration time basic synchronization, the chance oxygen secondary color time is several minutes only), the color that shows during anaerobic, can be with the different characteristics that become of developer kind, the remarkable difference of it and existing indicator also is to have multi-form, can make aqua on demand, charta, products such as tablet, these characteristics are that the present invention is exclusive, it is the product of we modularization formulating of recipe research method of creating itself, uses this method to make us successfully solve " dual-sucking seal-storage agent for fresh-keeping, its preparation method and use thereof " (seeing CN1012561B) series product development and the adjustable key problem in technology of CO2/O2 specific absorption; Also have only this method of utilization, just might make the invention hope of multi-form anaerobism indicator become the fact.
Formulation examples: show the optional glucose of peach liquid anaerobism indicator when showing blue look, anaerobic when requiring the preparation aerobic---methyne blue discoloration Icing Sugar is made colour-changing agent, is phenol redly made developer, sodium hydroxide is made the PH conditioning agent, by aforementioned aqua formulated.
Claims (8)
1, a kind of multi-form anaerobism indicator comprises colour-changing agent, PH conditioning agent, reductive agent, developer and vehicle, it is characterized in that:
1), contains the variable color Icing Sugar that carbohydrate and reversible oxidation-reduction indicator are made colour-changing agent;
2) the PH conditioning agent that, contains basic metal, alkaline earth metal hydroxides or other bases;
3), contain with good grounds colour developing requirement and the developer matched;
4), based on the variable color Icing Sugar, can make the product of aqua, charta, three kinds of formulations of tablet, its weight is composed as follows:
The variable color Icing Sugar:
1 part of colour-changing agent
PH conditioning agent 1.6-5 part
Icing Sugar 240-560 part
Distilled water 10-20 part
Colour developing liquid:
1 part of developer
1 part of PH conditioning agent
Distilled water 800-4300 part
Tablet formulation:
Variable color Icing Sugar 5-30 part
PH conditioning agent 0.5-12 part
Reductive agent 0-15 part
Colour developing liquid 0-30 part
Vehicle 40-160 part
Charta, aqua prescription:
Variable color Icing Sugar 5-30 part
PH conditioning agent 0.5-12 part
Reductive agent 0-15 part
Colour developing liquid 0-30 part
Diluting condition---adding distil water dilution dissolving:
Charta---distilled water: the variable color Icing Sugar=(40-200): 1
Distilled water: colour developing liquid=(10-300): 1
Aqua---distilled water: the variable color Icing Sugar=(200-300): 1
Distilled water: colour developing liquid=(100-850): 1
Show Color:
Show colour-changing agent oxidation state color during aerobic, show also ortho states color (when not adding developer) of developer color or colour-changing agent during anaerobic.
2, multi-form anaerobism indicator according to claim 1 is characterized in that the variable color Icing Sugar is a glucose---methyne blue discoloration powder.
3, multi-form anaerobism indicator according to claim 1, it is characterized in that developer can choose rose red b, phenol red, show red developer when phenolphthalein is made anaerobic; Choose bromothymol blue, thymol blue, xylenol orchid show blue look when making anaerobic developer.
4, multi-form anaerobism indicator according to claim 1 is characterized in that can adding iron protochloride, dichloride copper, tin protochloride, zinc chloride or other strong reductants such as Cu, Sn in the prescription, Fe, Zn make reductive agent.
5, multi-form anaerobism indicator according to claim 1 is characterized in that vehicle is made up of be shaped required filler, binding agent, lubricant of compressing tablet, and its component is:
Filler: binding agent: lubricant=(20-80): (20-70): (1-3).
6, multi-form anaerobism indicator according to claim 5, the material that it is characterized in that can be used as filler has oxyhydroxide, vitriol, carbonate, the white bole of aluminium, magnesium, beryllium.
7, multi-form anaerobism indicator according to claim 5 is characterized in that the material that can be used as binding agent has starch, carboxymethyl cellulose, Xylo-Mucine, polyvinyl alcohol, ethyl cellulose, Microcrystalline Cellulose.
8, multi-form anaerobism indicator according to claim 5, the material that it is characterized in that can be used as lubricant have hard ester acid and its esters, talcum powder, differential silica gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN91108195A CN1046315C (en) | 1991-10-11 | 1991-10-11 | Multidose anaerobic indicator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN91108195A CN1046315C (en) | 1991-10-11 | 1991-10-11 | Multidose anaerobic indicator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1071461A CN1071461A (en) | 1993-04-28 |
| CN1046315C true CN1046315C (en) | 1999-11-10 |
Family
ID=4909112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN91108195A Expired - Fee Related CN1046315C (en) | 1991-10-11 | 1991-10-11 | Multidose anaerobic indicator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1046315C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2525930T3 (en) * | 2005-08-02 | 2015-01-02 | Baxter International Inc. | Oxygen indicator for use in medical products and packaging containing an oxygen indicator |
| EP2762883B1 (en) * | 2011-09-30 | 2019-04-17 | ARKRAY, Inc. | Method for determining color change in oxidation-reduction indicator |
| CN103451261A (en) * | 2013-08-18 | 2013-12-18 | 青岛高科技工业园海博生物技术有限公司 | Anaerobic indicator |
| CN103868917A (en) * | 2014-03-25 | 2014-06-18 | 广东广益科技实业有限公司 | Powder oxygen indicator and preparation method thereof |
| CN104792778B (en) * | 2015-03-25 | 2018-02-27 | 广东广益科技实业有限公司 | A kind of oxygen indicator preparation method |
| KR102525572B1 (en) * | 2016-02-19 | 2023-04-25 | 가부시키가이샤 도키와 산교 | Oxygen detecting composition and oxygen detecting body |
| CN109856125B (en) * | 2018-12-15 | 2021-02-19 | 华南理工大学 | Oxygen-indicating type multi-tungstic acid cluster compound deoxidizer and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4023934A (en) * | 1975-12-22 | 1977-05-17 | Marion Laboratories, Inc. | Color indicator apparatus for presence of oxygen |
| JPS5448294A (en) * | 1977-09-22 | 1979-04-16 | Toppan Printing Co Ltd | Indicator for detecting capacity of oxygennsensitive substance and oxygen absorbent |
-
1991
- 1991-10-11 CN CN91108195A patent/CN1046315C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4023934A (en) * | 1975-12-22 | 1977-05-17 | Marion Laboratories, Inc. | Color indicator apparatus for presence of oxygen |
| JPS5448294A (en) * | 1977-09-22 | 1979-04-16 | Toppan Printing Co Ltd | Indicator for detecting capacity of oxygennsensitive substance and oxygen absorbent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1071461A (en) | 1993-04-28 |
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