CN104622515B - Body fluid electroconductibility sensor - Google Patents
Body fluid electroconductibility sensor Download PDFInfo
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- CN104622515B CN104622515B CN201510090647.2A CN201510090647A CN104622515B CN 104622515 B CN104622515 B CN 104622515B CN 201510090647 A CN201510090647 A CN 201510090647A CN 104622515 B CN104622515 B CN 104622515B
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Abstract
A body fluid electroconductibility sensor comprises a signal excitation source, analog conditioning circuits and a sensor probe. The signal excitation source is used for generating alternating signals capable of passing through a human body and synchronous positive and negative clock signals. A current signal output end of the signal excitation source is connected with the sensor probe, so that excitation can be output into the human body via the sensor probe. The synchronous positive and negative signals are connected with corresponding clock signal input ends of the analog conditioning circuits. The analog conditioning circuits are used for receiving the synchronous positive and negative clock signals of the signal excitation source, processing body fluid electroconductibility test signals collected by the sensor probe and outputting analog body fluid voltage signals, namely body fluid electroconductibility signals. The body fluid electroconductibility sensor has the advantage that the variation situation of body fluid ionic concentration affected by ovulatory cycles of corresponding women can be obtained according to varied data information of body fluid electroconductibility effectively, and accordingly, ovulation conditions of the women can be reflected.
Description
Technical field
The present invention relates to medical/domestic medical device field, in particular for sensing equipment field of ovulating, specifically
A kind of body fluid (saliva, urine, perspiration) conductivity sensor.
Background technology
Women passes through renin angiotensin in preovulatory, in blood estrogen level increase, the estrogen in blood
Na+, K+, Ca+ plasma concentration in II system fading margin body fluid, can cause the same period of human body fluid (saliva, perspiration, urine) total amount
Property change.Therefore it is female sharp during the same period change energy direct reaction blood for detect human body fluid (saliva, perspiration, urine) ion can be passed through
Element is changed with the synchronism of lutropin, and can shift to an earlier date 5 days or so predicting ovulation phases, and accuracy rate is very high, but
The method of testing for being currently based on this principle is but rarely used.Wherein one of reason is exactly also do not have the test female of maturation on market
Property by ovulatory cycle affected human body fluid (saliva, perspiration, urine) ion concentration change method of testing or instrument.
The content of the invention
The purpose of the present invention is, for the problems referred to above, to propose a kind of body fluid (saliva, perspiration, urine) conductivity sensor,
Corresponding women can effectively be obtained by ovulatory cycle according to the data message of body fluid (saliva, perspiration, urine) electric conductivity change
Body fluid (saliva, perspiration, urine) the ion concentration situation of change of impact, so as to reflect female ovulation situation.
The technical scheme is that：
A kind of body fluid conductivity sensor, it includes signal driving source, simulated modulation circuit and sensor probe；
Described signal driving source is used to produce the standard AC signal that can pass through human body and synchronous positive and negative clock signal,
The AC signal outfan of signal driving source is connected with sensor probe, is input into human body, letter by sensor probe as excitation
The positive and negative clock signal of synchronization of number driving source is connected with the corresponding clock signal input terminal of simulated modulation circuit；
Described simulated modulation circuit receives the positive and negative clock signal of synchronization of signal driving source, and sensor probe is adopted
The body fluid conductance measurement signal of collection carries out processing output body fluid analog voltage signal i.e. body fluid electric conductivity signal.
The signal driving source of the present invention includes AC signal generator, current-limiting circuit, fixed amplitude circuit and low latency phase inverter,
Described AC signal generator produces standard AC signal, and its signal output part sequentially passes through current-limiting circuit and fixed amplitude circuit,
Exported by sensor probe afterwards, the AC signal that described AC signal generator is produced also is exported as positive clock signals
To the positive clock signals input of simulated modulation circuit, the AC signal that AC signal generator is produced is also as positive clock signals
Export to the signal input part of low latency phase inverter, the signal output part of low latency phase inverter exports negative clock signal to simulating tune
The negative clock signal input of reason circuit.
The standard AC signal of the present invention, including standard sine wave, square wave and triangular wave；AC signal generator is produced
The AC wave shape of more than 500Hz, amplitude are 100mV -1V.
The simulated modulation circuit of the present invention includes low pass filter, waveform split circuit and waveform synthetic circuit, described
One end of low-pass filter circuit connects the body fluid conductance measurement signal that probe is gathered as the input of simulated modulation circuit, filtered
The corresponding signal input part of body fluid conductance measurement signal input waveform split circuit, the clock signal input terminal of waveform split circuit
It is connected with the corresponding positive and negative clock signal output terminal of signal driving source, the outfan and waveform synthetic circuit of waveform split circuit
Signal input part be connected, the output output body fluid electric conductivity signal of the output of waveform synthetic circuit as simulated modulation circuit.
The low pass filter of the present invention adopts second-order low-pass filter, preferred second order Butterworth LPF.
The waveform split circuit of the present invention includes four analog switches, and the electric signal input end of four analog switches is connect respectively
The body fluid conductance measurement signal of probe collection, the clock signal input terminal of analog switch one, two connect the output of signal driving source respectively
Positive clock, the clock signal input terminal of analog switch three, four connects the negative clock of signal driving source output respectively so that probe is adopted
The body fluid conductance measurement signal of collection passes through simulation in the positive half cycle of AC signal by analog switch one, two in negative half period
Switch three, four.
The waveform synthetic circuit of the present invention includes buffer one, two and biasing comparison circuit, the letter of described buffer one
Number input connects the signal output part of analog switch one, three, the signal input of buffer two as the input of waveform synthetic circuit
Another input as waveform synthetic circuit is held to connect the signal output part of analog switch two, four, buffer one, two is for separating
The ac small signal the opened i.e. waveform of body fluid conductance measurement signal carries out coupling synthesis, and the signal output part of buffer one, two is equal
It is connected with the signal input part of biasing comparison circuit, the described signal output part for biasing comparison circuit is used as waveform synthetic circuit
Output be sensor output, export body fluid electric conductivity signal.
The buffer one, two of the present invention adopts amplifier follower, preferred rail-to-rail amplifier follower.
The comparator that the biasing comparison circuit of the present invention is put using biasing.
Sensor of the invention probe can adopt medical stainless steel piece, flexible electrode using conductor material, conductor material
Circuit board, conducting polymer or electrical-conductive nanometer material；The inner surface of sensor probe has surfactant, and outer surface plating is useful
In antiseptical layers of chrome.
Beneficial effects of the present invention：
The body fluid conductivity sensor of the present invention can obtain the data of body fluid (saliva, perspiration, urine) electric conductivity change
Information, according to aforementioned information effectively can obtain body fluid (saliva, perspiration, urine) that corresponding women affected by ovulatory cycle from
Sub- concentration change situation, so as to reflect female ovulation situation.
Sensor of the invention is capable of achieving to become based on female ovulatory period human body fluid (saliva, perspiration, urine) ion concentration
The method of the principle test ovulation physiological period of change.And pass through data accuracy that the method measures base body more conventional
Warm method of testing, saliva crystallization observational method, cervical mucuss observational method are higher, and can shift to an earlier date 5--7 days or so predicting ovulation days,
This be also in the market can earliest and Precise detection of ovulation day method.
Sensor of the invention can be designed to various forms according to test body fluid species and the needs of test position；The biography
The low manufacture cost of sensor, it is easy to industrialization, with good market prospect.
The simulated modulation circuit of the present invention includes low pass filter, waveform split circuit and waveform synthetic circuit, and simulation is adjusted
Faint body fluid electrical conductance of the reason circuit by analysis human body, safety accurately measure the changing features of Human Physiology, this sensor
Measurement requirement, testee were measured before daily activity starts.
In the waveform split circuit of the present invention, due to the body fluid conductance signal and the signal driving source that return from probe sensor
I.e. AC signal is synchronous, therefore is passed through in the positive half cycle of the body fluid conductance measurement signal in AC signal of probe collection
Analog switch one, two, passes through analog switch three, four in negative half period.The positive and negative of body fluid conductance signal can so be efficiently separated
Half cycle, carries out waveform processing respectively, and as a result accuracy is high；In waveform synthetic circuit afterwards, isolate digital-to-analogue using buffer
Translation interface, so that the input resistance for making digital-to-analogue conversion interface affects to be minimized, analog switch in waveform split circuit in addition
The positive and negative body fluid conductance measurement signal for producing forms the body fluid of complete cycle by two buffer couplings and then by comparator
Conductance measurement signal, the method can by the small-signal of human body fluid conductance accurately amplified and quantitatively with measurement.
Description of the drawings
Fig. 1 is the theory diagram of the present invention.
Fig. 2 is the theory diagram of the signal driving source of the present invention.
Fig. 3 is the theory diagram of the simulated modulation circuit of the present invention.
Specific embodiment
The present invention is further illustrated with reference to the accompanying drawings and examples.
As shown in figure 1, a kind of body fluid conductivity sensor, it includes signal driving source, simulated modulation circuit and sensor
Probe；
Described signal driving source is used to produce the standard AC signal that can pass through human body and synchronous positive and negative clock signal,
The AC signal outfan of signal driving source is connected with sensor probe, is input into human body, letter by sensor probe as excitation
The positive and negative clock signal of synchronization of number driving source is connected with the corresponding clock signal input terminal of simulated modulation circuit；Described standard
AC signal, including standard sine wave, square wave and triangular wave；AC signal generator produces the AC wave shape of more than 500Hz, width
It is worth for 100mV -1V.
Described simulated modulation circuit receives the positive and negative clock signal of synchronization of signal driving source, and sensor probe is adopted
The body fluid conductance measurement signal of collection carries out processing output body fluid analog voltage signal i.e. body fluid electric conductivity signal；(conditioned signal
It can be the sine wave signal of 2kHz that input is standard AC signal, and amplitude is 700mV, and the signal returned from sensor probe is
With the impedance signal of sine wave homophase)
When being embodied as：
Signal driving source：In order to reduce corrosion and damage of the human body fluid (saliva, perspiration, urine) to sensor probe,
On signal driving source, it is necessary to which employing can pass through the low-voltage alternating-current small-signal of human body.Human body fluid (saliva, perspiration, urine) is led
Electrical sensor using corresponding current limliting and fixed ampllitude operation from the signal generating circuit for producing, are carried out to signal, and by this signal
The signal of telecommunication returned from sensor probe is processed as the clock of simulated modulation circuit.In order to avoid human body mucomembranous surface
Change of electrolyte, should adopt more than 500Hz waveform；In order to reduce the corrosion of probe, AC signal should be adopted, is adopted herein
As a example by sine wave signal；In order to safely allow electric current by human body mucomembranous surface, the small-signal of amplitude limit should be adopted, here by people
The Small Current Signal of body is less than 0.5mA.
Simulated modulation circuit：The major function of simulated modulation circuit has：Low-pass filter circuit, waveform are separated and Waveform composition
Deng.
Simulated modulation circuit also includes concentration range demarcating module, and the module is serially connected in the front end of low-pass filter circuit, wraps
TVS amplitude limiter circuits are included, open circuit amplifies measure circuit and short circuit amplification determines circuit：The normal person drawn by bulk sampling sample
Body body fluid (saliva, perspiration, urine) electric conductivity excursion, demarcates to the signal that sensor is returned, so as to improper
Method of testing carries out hardware exclusion.(hardware scope demarcation is the measured value of the measured value with off state of short circuit sensor state
Scope.It is 0-2048 that scope can be surveyed, and human normal scope estimated value is 300-2000)
Low-pass filter circuit：Process is filtered by low-pass filter circuit, i.e. second order Butterworth LPF, with
Just, during high speed analog-to-digital conversion, reduce impact of the noise conversion value to measured value.
Waveform split circuit：The Part I of hardware circuit is by waveform split circuit, is mainly used in entering mould
Positive-negative half-cycle process is carried out to the ac small signal that test position is returned before number converter.
Signal driving source not only as the signal source by human body but also as the clock source of waveform separation circuit part, to ensure
Phase invariant when converting to waveform.Low latency phase inverter in figure can use the integrated phase inverters of CMOS, such as 74HC04.Visit
Respectively by analog switch one, two, three, four, wherein analog switch one, two uses timing clock to the measurement conductance signal that head is returned
System, three, four using negative clock control, and the conductance signal measured after so processing passes through analog switch one, two in positive half cycle,
By analog switch three, four during negative half period, the process of waveform is completed afterwards by waveform synthetic circuit.
Waveform composition：The Part II of hardware algorithm circuit is by waveform synthetic circuit, is mainly used in separating
The waveform for processing of ac small signal carry out coupling synthesis, finally carry out data acquisition to rear class analog-digital converter.
Waveform composition part be mainly to separation after the positive and negative buffer put by biasing respectively, be then compared
Output.Buffer can use rail-to-rail amplifier follower, comparison circuit to be the comparator that biasing is put.
Waveform after above step and method are processed, can export the body fluid analog voltage signal for collecting as body fluid
Electric conductivity signal；Body fluid conductivity level accurately and is intuitively reacted most.
Sensor probe：Sensor probe uses medical stainless steel piece, inner surface to use special scaling powder and surface to live
Property agent, and in outer surface coating etc., for anticorrosion.
Three are partially integrated in a module, form human body fluid (saliva, perspiration, urine) conductivity sensor,
External interface can be passed through directly to pass the data signal for being available for analog-digital converter conversion.
Part that the present invention does not relate to is same as the prior art or can be realized using prior art.
Claims (11)
1. a kind of body fluid conductivity sensor, is characterized in that it includes signal driving source, simulated modulation circuit and sensor probe；
Described signal driving source is used to produce the standard AC signal that can pass through human body and synchronous positive and negative clock signal, signal
The AC signal outfan of driving source is connected with sensor probe, is input into human body by sensor probe as excitation, and signal swashs
Encourage the positive and negative clock signal of synchronization in source to be connected with the corresponding clock signal input terminal of simulated modulation circuit；
Described simulated modulation circuit receives the positive and negative clock signal of synchronization of signal driving source, and to sensor probe collection
Body fluid conductance measurement signal carries out processing output body fluid analog voltage signal i.e. body fluid electric conductivity signal；
Described signal driving source includes AC signal generator, current-limiting circuit, fixed amplitude circuit and low latency phase inverter, described
AC signal generator produces standard AC signal, and its signal output part sequentially passes through current-limiting circuit and fixed amplitude circuit, Zhi Houtong
Sensor probe output is crossed, the AC signal that described AC signal generator is produced also is exported to simulation as positive clock signals
The positive clock signals input of modulate circuit, AC signal generator produce AC signal also as positive clock signals export to
The signal input part of low latency phase inverter, the signal output part of low latency phase inverter export negative clock signal to simulated modulation circuit
Negative clock signal input；
Described simulated modulation circuit includes low pass filter, waveform split circuit and waveform synthetic circuit, described low pass filtered
One end of wave circuit connects the body fluid conductance measurement signal that probe is gathered, filtered body fluid electricity as the input of simulated modulation circuit
Lead the corresponding signal input part of measurement signal input waveform split circuit, the clock signal input terminal and signal of waveform split circuit
The positive and negative clock signal output terminal of correspondence of driving source is connected, the outfan of waveform split circuit and the signal of waveform synthetic circuit
Input is connected, and the output of waveform synthetic circuit exports body fluid electric conductivity signal as the output of simulated modulation circuit.
2. body fluid conductivity sensor according to claim 1, is characterized in that described standard AC signal, including standard
Sine wave, square wave and triangular wave.
3. body fluid conductivity sensor according to claim 1, is characterized in that described low pass filter is low using second order
Bandpass filter.
4. body fluid conductivity sensor according to claim 3, is characterized in that described second-order low-pass filter adopts two
Rank Butterworth LPF.
5. body fluid conductivity sensor according to claim 1, is characterized in that described waveform split circuit includes four
Analog switch, the electric signal input end of four analog switches connect the body fluid conductance measurement signal of probe collection, analog switch respectively
First, two clock signal input terminal connects the positive clock of signal driving source output, the clock signal input of analog switch three, four respectively
End connects the negative clock of signal driving source output respectively,
So that the body fluid conductance measurement signal of probe collection passes through analog switch one, two in the positive half cycle of AC signal, negative
Pass through analog switch three, four during half cycle.
6. body fluid conductivity sensor according to claim 1, is characterized in that described waveform synthetic circuit includes buffering
Device one, two and biasing comparison circuit, the signal input part of described buffer one connect simulation as the input of waveform synthetic circuit
The signal output part of switch one, three, the signal input part of buffer two connect simulation as another input of waveform synthetic circuit and open
Two, four signal output part is closed, buffer one, two is for the ac small signal to the separating i.e. ripple of body fluid conductance measurement signal
Shape carries out coupling synthesis, and the signal output part of buffer one, two is connected with the signal input part of biasing comparison circuit, described
The signal output part of biasing comparison circuit as waveform synthetic circuit output be sensor output, export body fluid electric conductivity and believe
Number.
7. body fluid conductivity sensor according to claim 6, is characterized in that described buffer one, two adopts amplifier
Follower.
8. body fluid conductivity sensor according to claim 7, is characterized in that described amplifier follower adopts rail-to-rail
Amplifier follower.
9. body fluid conductivity sensor according to claim 6, is characterized in that described biasing comparison circuit adopts biasing
The comparator put.
10. body fluid conductivity sensor according to claim 1, is characterized in that described sensor probe adopts conductor material
Material, conductor material adopt medical stainless steel piece, flexible electrode circuit board, conducting polymer or electrical-conductive nanometer material.
11. body fluid conductivity sensors according to claim 1, is characterized in that the inner surface tool of described sensor probe
There is surfactant, outer surface is coated with for antiseptical layers of chrome.
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| CN201510090647.2A CN104622515B (en) | 2015-02-27 | 2015-02-27 | Body fluid electroconductibility sensor |
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| CN201510090647.2A CN104622515B (en) | 2015-02-27 | 2015-02-27 | Body fluid electroconductibility sensor |
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| CN112630268A (en) * | 2020-11-26 | 2021-04-09 | 燕山大学 | Bipolar miniature ion concentration sensor and measurement system thereof |
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| CN204542210U (en) * | 2015-02-27 | 2015-08-12 | 江苏矽望电子科技有限公司 | body fluid conductivity sensor |
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| DE4137303C2 (en) * | 1991-11-13 | 1993-12-02 | Rheintechnik Weiland & Kaspar | Process for measuring the electrical conductivity of body fluids, as well as the related measuring probe |
| CN1127628A (en) * | 1995-01-28 | 1996-07-31 | 中国医学科学院基础医学研究所 | Organism body fluid distribution measuring analyzer |
| JP2001212098A (en) * | 2000-01-31 | 2001-08-07 | Tanita Corp | Equipment for measuring bioelectric impedance whose circuit is integrated into one chip |
| CN2669791Y (en) * | 2003-08-05 | 2005-01-12 | 彭飞 | Human body impedance measuring devices |
| CN100421617C (en) * | 2006-08-16 | 2008-10-01 | 中山市创源电子有限公司 | Human body impedance measuring apparatus and fat meter using same |
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| CN204542210U (en) * | 2015-02-27 | 2015-08-12 | 江苏矽望电子科技有限公司 | body fluid conductivity sensor |
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Application publication date: 20150520 Assignee: HANGZHOU WELBEING MEDICAL TECHNOLOGY CO.,LTD. Assignor: CYNOWARE ELECTRONICS Inc. Contract record no.: 2016320000227 Denomination of invention: Body fluid electroconductibility sensor License type: Exclusive License Record date: 20161228 |
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Denomination of invention: Body fluid conductivity sensor Granted publication date: 20170517 Pledgee: Nanjing Bank Co.,Ltd. Nanjing Financial City Branch Pledgor: CYNOWARE ELECTRONICS Inc. Registration number: Y2024980015258 |
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