CN104621158A - Sterilization composition containing prothioconazole and propineb and application thereof - Google Patents
Sterilization composition containing prothioconazole and propineb and application thereof Download PDFInfo
- Publication number
- CN104621158A CN104621158A CN201310573384.1A CN201310573384A CN104621158A CN 104621158 A CN104621158 A CN 104621158A CN 201310573384 A CN201310573384 A CN 201310573384A CN 104621158 A CN104621158 A CN 104621158A
- Authority
- CN
- China
- Prior art keywords
- propineb
- prothioconazoles
- bactericidal composition
- composition containing
- sterilization composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a sterilization composition containing prothioconazole and propineb and an application thereof. The sterilization composition takes prothioconazole and propineb as main effective ingredients. The sterilization composition can be applied to prevention and treatment of diseases of grains, fruit trees and vegetables, has a relatively high synergetic effect, can be used for overcoming and retarding drug resistance of bacteria with high sterilization speed and long duration, and reducing application cost, and has a prevention and treatment effect remarkably superior to that of a single preparation. The sterilization composition can be used for preventing and treating fungous diseases of crops, especially powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust disease, sclerotinia sclerotiorum, net blotch, scald, botrytis, black spot, brown blotch, black shank, early and late blight and other fungal diseases, and has an effect better than that of a single preparation.
Description
Technical field:
The present invention relates to a kind of bactericidal composition and application thereof, especially a kind of bactericidal composition and application thereof containing prothioconazoles and Propineb.
Background technology:
Prothioconazoles (Prothioconazole), it is the New-type wide-spectrum triazolinthione series bactericidal agent developed by Beyer Co., Ltd, chemical name: 2-(2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl-1-2-dihydro-3-1,2,4-triazole-3-sulfo-, molecular formula: C
14h
15c
l2n
3oS.Structural formula is as follows:
The mechanism of action of prothioconazoles is the precursor of sterol in Antifungi---the demethylation effect on lanosterol or the liquor-saturated l4 position of 24-methylene dihydro Mi hair, i.e. demethylation inhibitors (DMIs).Not only there is good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.By a large amount of field control effectiveness tests, result shows that prothioconazoles not only has good safety to crop, and preventing disease theraping effect is good, and volume increase obviously, and compare with triazole type biocide agent, prothioconazoles has the bactericidal activity of more wide spectrum.Be mainly used in control cereal crop as numerous diseases such as wheat, barley, rape, peanut, paddy rice and legume crops.Almost there is good control efficiency, as the powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc. of Wheat and barley to all wheat class diseases.The soil-borne disease of oily Lay and peanut can also be prevented and treated, as stalk break, and main foliage disease, as gray mold, black spot, brown spot, balck shank, stalk break and rust etc.
Propineb (Propineb), molecular formula: C5H10N2S4.Chemical name: many propylidene two (aminodithioformic acid).Structural formula:
White or micro-yellow powder.More than 160 DEG C decomposition.Vapour pressure <1mPa (20 DEG C).Relative density d231.813g/ml.Dissolubility (20 DEG C): water 0.01g/L, <0.1g/L in common solvent.Stable upon storage under cold, drying condition, decomposes in moist strong acid, highly basic medium.Mouse acute oral LD508500mg/kg great and mighty or powerful.1,2-trimethylene diamine and carbon disulphide, sodium hydroxide react, and product reacts i.e. obtained this product again with zinc nitrate.For preventing and treating potato, tomato powdery mildew, early blight and late blight etc.
The difficulty of prevention and cure of current phytopathogen is increasing, and on the one hand, along with the change of pattern of farming, the economic crops such as melon and fruit, vegetables cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under the medicament selection pressure continued, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention:
The object of the invention is the plant bactericidal composition containing prothioconazoles and Propineb providing a kind of applied widely, cost low, effective for above-mentioned technical problem.
A further object of the invention is to provide this bactericidal composition causes fungal disease medicine application as preparation control plant epiphyte, especially prevents and treats the application of the fungal disease medicine such as powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease, gray mold, black spot, brown spot, balck shank, early late blight as preparation.
The object of the invention is to be realized by following measures:
Contain a bactericidal composition for prothioconazoles and Propineb, wherein prothioconazoles and Propineb weight ratio are 1 ~ 70:1 ~ 50, are preferably 1 ~ 35:1 ~ 25, more preferably 1 ~ 10:1 ~ 20, most preferably are 1:2 ~ 6.
In bactericidal composition of the present invention, the percentage by weight that both prothioconazoles and Propineb account for composition is 2 ~ 80%, preferably 10 ~ 40%.
Described bactericidal composition, prothioconazoles and Propineb and known auxiliary agent and excipient are re-dubbed the formulation that agricultural chemicals allows.These known auxiliary agents have dispersant, diffusant, defoamer, wetting agent, disintegrant etc., calcium dodecyl benzene sulfonate can be adopted, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide addition product, the rare ether of polyoxyethylene polyoxy third, castor oil polyoxyethylene ether, polyoxyethylene nonylphenol ether, TWEEN Series, fatty alcohol-polyoxyethylene ether, polyethylene glycol series, Sulfonates, carboxylate, sulphate, phosphate, phosphite, lignosulfonates, xanthans, phenol formaldehyde condensate, ammonium salt, quaternary etc., excipient comprises cyclohexanone, dimethylbenzene, various solvent naphtha, water, antifreezing agent (as propane diols) and deionized water etc.Above auxiliary agent, excipient and other auxiliary material can be alone or and use.
Described bactericidal composition, its formulation is missible oil, wetting powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
The described bactericidal composition containing prothioconazoles and Propineb has the application preventing and treating resistance plant fungal disease medicine as preparation.
The described bactericidal composition containing prothioconazoles and Propineb prevents and treats the application of powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease, gray mold, black spot, brown spot, balck shank and early late blight medicine as preparation.
Beneficial effect of the present invention:
Bactericidal composition of the present invention is as the application of preparation control resistance plant fungi-medicine, and the application especially preventing and treating powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease, gray mold, black spot, brown spot, balck shank and early late blight medicine as preparation all has significant effect.Bactericidal composition of the present invention can produce higher synergistic function, and activity is greater than the activity of independent component.
Compared with prior art beneficial effect of the present invention: (1) is compared with single dose, said composition antagonism fungal disease as powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease, gray mold, black spot, brown spot, balck shank and early late blight have obvious synergistic function, overcome and delayed pesticide resistance, expanding prevention is composed, and significantly improves control efficiency; (2) control recruitment, drug cost is reduced; (3) alternative routine and the easy agricultural chemicals producing resistance; (4) compared with single dose, produce and use cost reduction; (5) the drug-fast generation of Antifungi, its successful uses higher than its single dose.
Embodiment:
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method, and " % " of the present invention is mass percent.
Two kinds of reactive compounds can be processed into any one formulation of permission, with specific embodiment, the preparation that two kinds of active ingredients are processed into are described below, but the preparation that these two kinds of active components can be processed be not limited only to following listed by.
Embodiment 1:
By prothioconazoles 5g, Propineb 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained active ingredient weight percentage is 15% wetting powder.
Embodiment 2:
By prothioconazoles 3g, Propineb 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained active ingredient weight percentage is 15% wetting powder.Embodiment 3:
By prothioconazoles 2g, Propineb 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and obtained active ingredient weight percentage is 14% wetting powder.Embodiment 4:
Take 5g prothioconazoles, 50g Propineb, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making active ingredient weight percentage is 55% prothioconazoles-Propineb aqueous emulsion.
Embodiment 5:
Take 2g prothioconazoles, 30g Propineb, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making active ingredient weight percentage is 32% prothioconazoles-Propineb microemulsion.
Embodiment 6:
Take 1g prothioconazoles, 5g Propineb, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, and making active ingredient weight percentage is 6% prothioconazoles-Propineb aqueous emulsion.
Embodiment 7:
Take 50g prothioconazoles, 20g Propineb, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor oil polyoxyethylene ether 2g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 70% prothioconazoles-Propineb missible oil.
Embodiment 8:
Take 2g prothioconazoles, 40g Propineb, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 42% prothioconazoles-Propineb missible oil.
Embodiment 9:
Take 5g prothioconazoles, 20g Propineb, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and making active ingredient weight percentage is 25% prothioconazoles-Propineb microemulsion.
Embodiment 10:
Take 5g prothioconazoles, 0.5g Propineb, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 5.5% prothioconazoles-Propineb missible oil.
Embodiment 11:
Take 5g prothioconazoles, 30g Propineb, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and making active ingredient weight percentage is 35% prothioconazoles-Propineb missible oil.
Embodiment 12:
Take 10g prothioconazoles, 10g Propineb, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make active ingredient weight percentage is 20% prothioconazoles-Propineb suspending agent.
Embodiment 13:
Take 30g prothioconazoles, 12g Propineb, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make active ingredient weight percentage is 42% prothioconazoles-Propineb suspending agent.
Embodiment 14:
Take 2g prothioconazoles, 5g Propineb, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, white carbon 3g, diatomite complement to 100g, and it is 7% prothioconazoles-Propineb water dispersion granule that above raw material is made active ingredient weight percentage by water dispersible granular agent method.
Embodiment 15:
Take 4g prothioconazoles, 13g Propineb, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 17% prothioconazoles-Propineb water dispersion granule that above raw material is made active ingredient weight percentage by water dispersible granular agent method.
Embodiment 16:
Take 5g prothioconazoles, 15g Propineb, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make active ingredient weight percentage is 20% prothioconazoles-Propineb suspending agent
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure different agents to the EC50 value of bacterial strain, adopt co-toxicity coefficient computational methods, calculate the co-toxicity coefficient (CTC) of mixture, determine the building performance of mixture, circular is as follows:
With single dose a certain in mixture for standard agent (usually selecting EC50 junior), calculate:
Single dose toxicity index=standard agent EC50/ single dose EC50 × 100
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
EC50 value × 100 of the EC50 value/mixture of actual measurement toxicity index=standard single dose
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
When co-toxicity coefficient classification: CTC is greater than 120, mixture has synergetic, and be antagonism when CTC is less than 80, CTC is summation action between 80-120.
Table 1: prothioconazoles+Propineb different ratio is to the indoor biometrics result of tomato late blight (Phytophthora infestans (Mont.) de Bary.)
| Medicament | Virulence regression equation | EC50（mg/L） | Co-toxicity coefficient |
| Prothioconazoles (A) | Y=2.24X+5.57 | 0.555 | - |
| Propineb (B) | Y=1.46X+3.96 | 5.128 | - |
| A:B=1:2 | Y=2.41X+2.78 | 8.319 | 152.02 |
| A:B=1:4 | Y=1.58X+3.29 | 12.032 | 148.72 |
| A:B=1:6 | Y=2.07X+2.68 | 13.168 | 165.28 |
Prothioconazoles (A) and Propineb (B) is adopted to test the indoor biometrics of tomato late blight with different ratio in table 1, as shown in Table 1, composition co-toxicity coefficient of the present invention is all greater than 120, and namely the present composition has good synergetic, and its effect is all better than single dose kind.
Field control effectiveness test:
1. test process: the difference of each composition of this experimental evidence establishes three dosings respectively, and wherein, dosing is active ingredient prothioconazoles (A) and active ingredient Propineb (B) quality sum.Contrast medicament is agricultural chemicals single dose 70% Propineb WP and 5% prothioconazoles ME and blank clean water experiment respectively.
2. test method: each plot area is 66.7m
2, repeat 3 times; Investigation drug effect method before dispenser after Investigation and Prevention is: random sampling 5 point in test treatment region, carries out severity Scaling, calculate preventive effect according to national field trial relevant criterion.Result of the test sees the following form:
Table 2 field control effectiveness test result
Shown by field efficacy result, as shown in Table 2, the present composition has obvious synergistic function, and the control efficiency of composition is excellent, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Claims (10)
1. contain a bactericidal composition for prothioconazoles and Propineb, it is characterized in that: described prothioconazoles and the weight ratio of Propineb are 1 ~ 70:1 ~ 50.
2. the bactericidal composition containing prothioconazoles and Propineb according to claim 1, is characterized in that: described prothioconazoles and the weight ratio of Propineb are 1 ~ 35:1 ~ 25.
3. the bactericidal composition containing prothioconazoles and Propineb according to claim 2, is characterized in that: described prothioconazoles and the weight ratio of Propineb are 1 ~ 10:1 ~ 20.
4. the bactericidal composition containing prothioconazoles and Propineb according to claim 3, is characterized in that: described prothioconazoles and the weight ratio of Propineb are 1:2 ~ 6.
5. the bactericidal composition containing prothioconazoles and Propineb according to claim 1, is characterized in that: the weight percentage that both described prothioconazoles and Propineb account for composition is 5.5 ~ 80%.
6. the bactericidal composition containing prothioconazoles and Propineb according to claim 5, is characterized in that: the weight percentage that both described prothioconazoles and Propineb account for composition is 10 ~ 40%.
7. the bactericidal composition containing prothioconazoles and Propineb according to claim 1, is characterized in that: described bactericidal composition with prothioconazoles and Propineb for principle active component and insecticides adjuvant, excipients are mixed with the formulation that agricultural chemicals allows.
8. the bactericidal composition containing prothioconazoles and Propineb according to claim 7, is characterized in that: described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
9. the bactericidal composition containing prothioconazoles and Propineb according to claim 1 has the application preventing and treating resistance plant fungal disease medicine as preparation.
10. the bactericidal composition containing prothioconazoles and Propineb according to claim 9 has the application preventing and treating powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease, gray mold, black spot, brown spot, balck shank and early late blight medicine as preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310573384.1A CN104621158A (en) | 2013-11-15 | 2013-11-15 | Sterilization composition containing prothioconazole and propineb and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310573384.1A CN104621158A (en) | 2013-11-15 | 2013-11-15 | Sterilization composition containing prothioconazole and propineb and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104621158A true CN104621158A (en) | 2015-05-20 |
Family
ID=53200810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310573384.1A Pending CN104621158A (en) | 2013-11-15 | 2013-11-15 | Sterilization composition containing prothioconazole and propineb and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104621158A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1252690A (en) * | 1997-04-18 | 2000-05-10 | 拜尔公司 | Fungicide active substance combinations |
| CN102258039A (en) * | 2011-08-26 | 2011-11-30 | 陕西美邦农药有限公司 | Bactericidal composition containing prothioconazole and thiocarbamates |
-
2013
- 2013-11-15 CN CN201310573384.1A patent/CN104621158A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1252690A (en) * | 1997-04-18 | 2000-05-10 | 拜尔公司 | Fungicide active substance combinations |
| CN102258039A (en) * | 2011-08-26 | 2011-11-30 | 陕西美邦农药有限公司 | Bactericidal composition containing prothioconazole and thiocarbamates |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104642331A (en) | Bactericidal composition containing prothioconazole and tebuconazole and application thereof | |
| CN104621130A (en) | Sterilization composition containing prothioconazole and azoxystrobin and application thereof | |
| CN105766952A (en) | Sterilization composition containing isopyrazam and folpet and application of sterilization composition | |
| CN104621126A (en) | Sterilization composition containing prothioconazole and difenoconazole and application thereof | |
| CN104621123A (en) | Sterilization composition containing prothioconazole and fluopicolide and application thereof | |
| CN104621125A (en) | Sterilization composition containing prothioconazole and trifloxystrobin and application thereof | |
| CN104621168A (en) | Sterilization composition containing prothioconazole and prochloraz-manganese chloride and application thereof | |
| CN105766933A (en) | Bixafen and prothioconazole containing bactericidal composition and application thereof | |
| CN104642335B (en) | A kind of bactericidal composition containing prothioconazoles and bupirimate and application thereof | |
| CN104621127A (en) | Sterilization composition containing prothioconazole and fenoxanil and application thereof | |
| CN104621129A (en) | Sterilization composition containing prothioconazole and metalaxyl-M and application thereof | |
| CN105794794A (en) | Bactericidal composition containing isopyrazam and tiadinil and application of bactericidal composition | |
| CN104642333A (en) | Prothioconazole and kresoxim-methyl-containing sterilization composition and application thereof | |
| CN104642376A (en) | Bactericidal composition containing prothioconazole and flusilazole and application thereof | |
| CN104642367A (en) | Bactericidal composition containing prothioconazole and prochloraz and application thereof | |
| CN104621149A (en) | Sterilization composition containing prothioconazole and thifluzamide and application thereof | |
| CN104621154A (en) | Sterilization composition containing prothioconazole and benthiavalicarb-isopropyl and application thereof | |
| CN104621158A (en) | Sterilization composition containing prothioconazole and propineb and application thereof | |
| CN104642328A (en) | Sterilization composition containing prothioconazole and isoprothiolane and use thereof | |
| CN104642332A (en) | Bactericidal composition containing prothioconazole and diniconazole and application thereof | |
| CN105532721A (en) | Sterilization composition containing bixafen and ethirimol and application of sterilization composition | |
| CN104621155A (en) | Sterilization composition containing prothioconazole and polyoxin and application thereof | |
| CN104621153B (en) | A kind of bactericidal composition containing prothioconazoles and Propamocarb and application thereof | |
| CN104621128A (en) | Sterilization composition containing prothioconazole and metalaxyl and application thereof | |
| CN104621124A (en) | Sterilization composition containing prothioconazole and myclobutanil and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150520 |