CN104621102A

CN104621102A - Method for preparing adhesive abamectin polydopamine microcapsule by employing emulsion interface polymerization method

Info

Publication number: CN104621102A
Application number: CN201410310095.7A
Authority: CN
Inventors: 贾鑫; 盛文波; 李卫; 刘志勇
Original assignee: Shihezi University
Current assignee: Shihezi University
Priority date: 2014-06-26
Filing date: 2014-06-26
Publication date: 2015-05-20
Anticipated expiration: 2034-06-26
Also published as: CN104621102B

Abstract

The invention relates to a method for preparing an adhesive abamectin polydopamine microcapsule by employing an emulsion interface polymerization method, and aims at solving the problems that abamectin is easy to decompose in light, and most of dosage forms cannot effectively remain on a plant leaf surface. The method comprises the following steps: with a Tris-HCl buffer liquid containing cetyltrimethylammonium chloride (1.5%m/v of water phase) as a water solution, and an n-butyl alcohol solution containing abamectin as an oil phase, carrying out oxidizing auto-polymerization on an emulsion interface through polydopamine (the density is 1mg/mL); carrying out mechanical agitation at room temperature for 24 hours; and centrifugally washing to obtain the abamectin polydopamine microcapsule with stickiness and light stability, wherein the microcapsule has temperature and pH control-release property. The abamectin polydopamine microcapsule which is uniform in size, high in loading capacity and high in stickiness can be prepared by the method disclosed by the invention; and the method is high in yield and simple in steps, and can be applied to industrialization.

Description

A kind of emulsion interface polymerization prepares the method that adhesiveness Avermectin gathers dopamine microcapsules

Technical field

The present invention relates to one and first Avermectin is carried out emulsification, then on emulsion interface, carry out oxidation auto polymerization by dopamine and derivative, obtain the method for the microcapsules with adhesiveness, temperature controlled release, pH controlled release and photostability.

Background technology

China is large agricultural country, and pest is multiple, take place frequently, retransmit.Use chemical pesticide control disease, worm, crop smothering be main at present and effectively preventing means.But the agricultural chemicals sprayed away at present only has 20% ~ 30% to hold stays and be deposited on target, other 70% ~ 80% drift or be lost in soil, pollutes the living environment of animals and humans.The reason causing agricultural chemicals to waste and to run off mainly contains two: one, is applied in the agricultural chemicals on crops, can not need to asking medicine according to crop growth, after exposing to the sun and rain, most of can volatilization or be decomposed and cannot effectively utilize; Its two, the conventional formulations of pesticide can not be formed in crop surface effectively sprawls and stops, and result in most of agricultural chemicals and runs off very soon after administration.

Avermectin is a kind of dual-purpose antibiotic of novel farming animals of efficient, low toxicity, high selectivity, is the substitute products of China's high-toxic pesticide.But Avermectin is the labile material of a kind of chance light, improves the Agricultural Exploitation of its photostability for Avermectin, and the prolongation lasting period has great importance.At present, adopting load technology Avermectin to be embedded in controlled-release material is delay its light to decompose and the effective way carrying out slow releasing.Wherein, polyethylene glycol, hollow porous Nano-meter SiO_2 ₂, gelatin, TiO ₂, mesoporous activated carbon, inorganic mineral diatomite and natural and synthesized polymer material be all commonly used for the stable sustained-release carrier of Avermectin to prepare sustained release preparation.But the Avermectin controlled release agent type of current bibliographical information all concentrates on photostability and slow releasing that research improves Avermectin, and changes the Co ntrolled release type Avermectin formulation also rarely seen report of release rule according to external environmental condition change.Especially researcher is seldom had can to notice the interaction of these insecticides and different plant leaf surface.Therefore, develop between same plant leaf surface and have stronger active force, extend its time of staying at crop surface, the novel agrochemical formulation simultaneously with photostability and controlled capability is particularly important.

Summary of the invention

See that light easily decomposes for Avermectin, conventional missible oil formulation organic matter usage amount is large and different and cause that availability is low, usage amount large and the problem of environmental pollution in the different plant leaf surface time of staying, intend from bionics angle, in conjunction with control release technic, based on dopamine chemistry, by the method for emulsion polymerisation, prepare bionic adhesion Avermectin and gathered dopamine microcapsules; The research of its release dynamics shows that these microcapsules have control slowly-releasing and photostability; Verify that bionical poly-dopamine microcapsules water suspension ties up on cotton and corn blade face and has adhesion property by ESEM.This research gathers the development of dopamine controlled release agricultural chemicals for bionic adhesion Avermectin and applies based theoretical.Meanwhile, research and development and application for being suitable for the controlled release agricultural chemicals of Xinjiang crop and environmental quality provide technical support.The technical solution adopted in the present invention step is as follows:

First 1.5g hexadecyltrimethylammonium chloride (1.5%m/v aqueous phase) is dissolved in the aqueous solution obtaining surfactant in 100mL Tris-HCl (pH=8.5) buffer solution, 0.1g Avermectin is dissolved in 10mL n-butanol and obtains oil phase; Then oil phase is joined rapidly in the aqueous solution above, high degree of agitation 30min; Add 0.1g dopamine (concentration is 1mg/mL) subsequently and on emulsion interface, carry out oxidation auto polymerization, 300r/min mechanical agitation 24h under room temperature.Water centrifuge washing 3-4 time, 45 DEG C of vacuum dryings obtain the microcapsules with adhesiveness and photostability, and these microcapsules have temperature and pH controlled capability.In these microcapsules, the load capacity of Avermectin can reach 66.5%, and productive rate can reach 75% ~ 85%.

Accompanying drawing explanation

The Avermectin that emulsion interface polymerization obtains by field emission microscopy observation gathers dopamine microcapsules, and as can be seen from the figure capsule size is homogeneous, particle diameter, at about 215nm, has good adhesiveness.Accompanying drawing 1 gathers the SEM photo of dopamine microcapsules for Avermectin.

Embodiment

Below in conjunction with embodiment, the present invention will be further described, but content of the present invention is not limited only to content involved in embodiment.

1.5g hexadecyltrimethylammonium chloride (1.5%m/v aqueous phase) is first dissolved in the aqueous solution obtaining surfactant in 100mLTris-HCl (pH=8.5) buffer solution by embodiment 1, and 0.1g Avermectin is dissolved in 10mL n-butanol and obtains oil phase; Then oil phase is joined rapidly in the aqueous solution above, high degree of agitation 30min; Add 0.1g dopamine (concentration is 1mg/mL) subsequently and on emulsion interface, carry out oxidation auto polymerization, 300r/min mechanical agitation 24h under room temperature.Water centrifuge washing 3-4 time, 45 DEG C of vacuum dryings obtain the microcapsules with adhesiveness and photostability, and these microcapsules have temperature and pH controlled capability.In these microcapsules, the load capacity of Avermectin can reach 66.5%, and productive rate can reach 75% ~ 85%.

Claims

1. the present invention relates to a kind of emulsion interface polymerization and prepare the method that adhesiveness Avermectin gathers dopamine microcapsules, it is characterized in that following steps:

First 1.5g hexadecyltrimethylammonium chloride (1.5%m/v aqueous phase) is dissolved in the aqueous solution obtaining surfactant in 100mL Tris-HCl (pH=8.5) solution, 0.1g Avermectin is dissolved in 10mL n-butanol and obtains oil phase; Then oil phase is joined rapidly in the aqueous solution above, high degree of agitation 30min; Add 0.1g dopamine (concentration is 1mg/mL) subsequently and on emulsion interface, carry out oxidation auto polymerization, 300r/min mechanical agitation 24h under room temperature, obtain the microcapsules with adhesiveness and photostability, and these microcapsules have temperature and pH controlled capability.In these microcapsules, the load capacity of Avermectin can reach 66.5%, and productive rate can reach 75% ~ 85%.

2. according to right 1, it is characterized in that: dissolve hexadecyltrimethylammonium chloride with Tris-HCl buffer solution (pH=8.5), surfactant concentration is 1.5% (m/v aqueous phase); By n-Butanol soluble Avermectin (concentration is 10mg/mL) as oil phase, profit phase volume ratio is 1: 10; Oil phase joins rapidly in the aqueous solution of surfactant, high degree of agitation 30min; Dopamine concentration is 1mg/mL; Each raw material add order, rotating speed and the control in reaction time; Product washes centrifugal 3-4 time with water, isolates the microcapsules of size uniformity, 45 DEG C of vacuum dryings.