CN104606634A - Traditional Chinese medicine composition for treating hemicrania, and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating hemicrania, and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating hemicrania, and a preparation method of the traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese pharmacology and pharmaceutics. The traditional Chinese medicine composition is prepared from the following raw medicines: sticktight, tenuifolia, artemisia stelleriana, cassia twigs, mountain licorice, white baneberry, radix curcumae, peach kernels, liquorice, semen boitae, ligusticum wallichii, rhizoma acori graminei, astragalus membranaceus, white atractylodes rhizome, leonurus, white paeony roots, pinellia ternata and salvia miltiorrhiza. The traditional Chinese medicine composition disclosed by the invention has the benefits that the compounding is simple, the absorption effect is good, the curative effect is obvious, side effects are not generated, and the safety is high; the traditional Chinese medicine composition is favorable for relieving symptoms for patients in time.
Description
Technical field
The invention belongs to Chinese materia medica and galenic pharmacy technical field, relate to and be used for the treatment of migrainous Chinese medicine composition, and the preparation method of this Chinese medicine composition.
Background technology
Neurology Department is independently secondary subject, main diagnosis and treatment cerebrovascular disease (cerebral infarction, cerebral hemorrhage), migraine, brain inflammation disease (encephalitis, meningitis), myelitis, epilepsy, dementia, nervous system degeneration are sick, metabolic disease and heredopathia, trigeminal neuralgia, sciatic neuropathy, peripheral neuropathy (numb limbs and tense tendons, unable) and myasthenia gravis etc.
Migraine is a kind of misery, the disease sometimes making people's weakness, and it is often relevant to multiple Neurological signs.Its prevalence in crowd is higher than other nervous system disease any.In the past, migrainous treatment was considered to directly cause migrainous meningovascular pathologic change mainly for treatment.Now, people more and more in depth recognize that abnormality of nerve function may be that disease produces and causes an intraictal larger reason.
At present, the migrainous method of domestic and international treatment is more, as western medicine method, the conventional medicine such as pizotifen, amitriptyline is treated, and substantially all has some curative effects, but can only take stopgap measures and can not effect a permanent cure, and the side effect of these medicines is a lot, especially very large to lesions of liver and kidney, just relief of symptoms, cannot play the object of thoroughly curing.
Summary of the invention
Technical problem to be solved by this invention is to provide one and is used for the treatment of migrainous Chinese medicine composition.
English name or the Latin name of raw material of Chinese medicine of the present invention are called: Herba Bidentis Bipinnatae Herba BidentisBipinnatae; Herba Schizonepetae Herba Schizonepetae; Herba Artemisiae Sieversianae Herba Artemisiae Sieversianae, Ramulus Cinnamomi Ramulus Cinnamomi; Ramulus et Folium Mussaendae Pubescentis Caulis et Folium Mussaenda Pubescentis; Rhizoma Arisaematis Rhodobryum giganteum (Schwaegr.) Par. [Bryum giganteumSchwaegr.; Mnium giganteum Schwaegr.], different name has blood coagulation resisting function also known as Rhodobryum giganteum(Hook.) Par., Rhodobryum giganteum, and tranquilizing by nourishing the heart cures mainly neurasthenia; Radix Curcumae Radix Curcumae; Semen Persicae SemenAmygdali; Radix Glycyrrhizae Radix et Rthizoma Glycyrrhizae; Semen Platycladi Semen Platycladi, Rhizoma Chuanxiong Rhizoma Chuanxiong; Rhizoma Acori Graminei Rhizoma Acori Tatarinowii; Radix Astragali RadixAstragali; Rhizoma Atractylodis Macrocephalae Rhizoma Atractylodis Macrocephalae; Herba Linderniae Crustaceae HerbaLeonuri; Radix Paeoniae Alba Radix Paeoniae Alba; Rhizoma Pinelliae Rhizoma Pinelliae; Radix Salviae Miltiorrhizae RadixSalviae Miltiorrhizae; Fructus Schisandrae Chinensis (Radix Schisandrae Bicoloris Fructus Schisandrae Chinensis and/or Fructus Schisandrae Sphenantherae Fructus Schisandrae Sphenanthenae), Radix Rehmanniae Rehmanniaglutinosa (Gaetn.) Libosch.ex Fisch.et Mey. Scrophulariaceae, Radix Rehmanniae platymiscium, the tuber of Radix Rehmanniae.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: one is used for the treatment of migrainous Chinese medicine composition, is made up of following crude drug: Herba Bidentis Bipinnatae, Herba Schizonepetae, Herba Artemisiae Sieversianae, Ramulus Cinnamomi, Ramulus et Folium Mussaendae Pubescentis, Rhizoma Arisaematis, Radix Curcumae, Semen Persicae, Radix Glycyrrhizae, Semen Platycladi, Rhizoma Chuanxiong, Rhizoma Acori Graminei, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Leonuri, the Radix Paeoniae Alba, the Rhizoma Pinelliae, Radix Salviae Miltiorrhizae.
Be used for the treatment of migrainous Chinese medicine composition as above, preferably, be made up of the crude drug of following weight portion: Herba Bidentis Bipinnatae 2 ~ 4 parts, Herba Schizonepetae 4 ~ 6 parts, Herba Artemisiae Sieversianae 5 ~ 8 parts, Ramulus Cinnamomi 5 ~ 7 parts, Ramulus et Folium Mussaendae Pubescentis 5 ~ 6 parts, Rhizoma Arisaematis 4 ~ 6 parts, Radix Curcumae 4 ~ 5 parts, 5 ~ 15 parts, Semen Persicae, 5 ~ 10 parts, Radix Glycyrrhizae, Semen Platycladi 3 ~ 4 parts, Rhizoma Chuanxiong 2 ~ 3 parts, Rhizoma Acori Graminei 15 ~ 25 parts, the Radix Astragali 15 ~ 25 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 25 parts, Herba Leonuri 15 ~ 25 parts, the Radix Paeoniae Alba 10 ~ 20 parts, the Rhizoma Pinelliae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts.
Be used for the treatment of migrainous Chinese medicine composition as above, preferably, Herba Bidentis Bipinnatae 3 parts, Herba Schizonepetae 5 parts, Herba Artemisiae Sieversianae 7 parts, Ramulus Cinnamomi 6 parts, Ramulus et Folium Mussaendae Pubescentis 5 parts, Rhizoma Arisaematis 5 parts, Radix Curcumae 4 parts, 12 parts, Semen Persicae, 9 parts, Radix Glycyrrhizae, Semen Platycladi 4 parts, Rhizoma Chuanxiong 2 parts, Rhizoma Acori Graminei 23 parts, the Radix Astragali 24 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Herba Leonuri 22 parts, the Radix Paeoniae Alba 17 parts, the Rhizoma Pinelliae 18 parts, Radix Salviae Miltiorrhizae 14 parts.
The present invention also provides the preparation method being used for the treatment of migrainous Chinese medicine composition as mentioned above, comprises the following steps:
Step (1), weighs crude drug according to above-mentioned weight portion, and directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture;
Step (2), obtains Chinese medicine extract with water and/or alcohol extraction gained Traditional Chinese drug mixture.
The present invention is used for the treatment of the preparation method of migrainous Chinese medicine composition as mentioned above, further, also comprise step (3), the Chinese medicine extract prepared to step (2) crosses 60-80 mesh sieve, adds the Radix Rehmanniae of 60-80 mesh sieve and the water extract of Fructus Schisandrae Chinensis; The weight ratio of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 1:2 ~ 6; The weight portion of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 2 ~ 5% of crude drug total weight parts.
The present invention adopts above-mentioned further beneficial effect to be: the water extract adding Radix Rehmanniae and Fructus Schisandrae Chinensis in Chinese medicine extract prepared by step (2), not only can to cooperatively interact treatment migraine with the property of medicine of crude drug, and research also finds to add the Radix Rehmanniae of aforementioned proportion and Fructus Schisandrae Chinensis can significant prolongation Chinese medicine extract shelf lives.
Also find in above-mentioned preparation process, Chinese medicine extract prepared by step (2) is placed after 10 hours after crossing 60-80 mesh sieve, namely have and precipitate generation in a large number, and add the generation that the Radix Rehmanniae of aforementioned proportion and Fructus Schisandrae Chinensis effectively can reduce precipitation, within the shortest 40 hours, just occur precipitation.
Be used for the treatment of the preparation method of migrainous Chinese medicine composition as above; preferably; also comprise the concentrated, dry of Chinese medicine extract or Chinese drugs agentia and make the step of capsule: the operation that above-mentioned steps is concrete is: Chinese medicine extract or Chinese drugs agentia are-0.07MPa at pressure; temperature 70-80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 45-55 DEG C of drying, loads dried particles that frequency is 606-630THz, wave-length coverage is in the blue capsule shells of hydroxypropyl emthylcellulose (HPMC) in the material of 476nm-495nm.
Present invention employs wave-length coverage to take up the present invention in the blue capsule shells of 476nm-495nm and be used for the treatment of migrainous Chinese medicine composition, can the stability of significant prolongation medicine drug effect.
Be used for the treatment of the preparation method of migrainous Chinese medicine composition as above, preferably, with water extraction gained Traditional Chinese drug mixture, described abstract methods is: the water extraction 1 ~ 3 time adding Chinese medicine weight 6 ~ 10 times, carries 1 ~ 3 hour at every turn.Preferably, extract three times, first time adds the water extraction 2 hours of Chinese medicine weight 10 times, and second time and third time all add the water 1 hour of Chinese medicine weight 8 times, merge mixed liquor.
Be used for the treatment of the preparation method of migrainous Chinese medicine composition as above, preferably, described abstract methods is: the water extraction 2 times adding Chinese medicine weight 8 times, carries 2 hours at every turn.
The invention has the beneficial effects as follows: the mutual compatibility of plurality of raw materials medicine of the present invention obtains medicament, and preparation is simple, and good absorbing effect, evident in efficacy, have no side effect, safety is high, is conducive to sufferer and alleviates condition of illness in time.
Detailed description of the invention
Be described principle of the present invention and feature below in conjunction with embodiment, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 2g, Herba Schizonepetae 6g, Herba Artemisiae Sieversianae 5g, Ramulus Cinnamomi 7g, Ramulus et Folium Mussaendae Pubescentis 5g, Rhizoma Arisaematis 6g, Radix Curcumae 4g, Semen Persicae 15g, Radix Glycyrrhizae 5g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 25g, Radix Astragali 15g, Rhizoma Atractylodis Macrocephalae 25g, Herba Leonuri 15g, Radix Paeoniae Alba 20g, Rhizoma Pinelliae 10g, Radix Salviae Miltiorrhizae 20g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 2 times of Traditional Chinese drug mixture weight 6 times, carries 2 hours at every turn and obtain Chinese medicine extract.
The Chinese medicine extract that embodiment 1 method is prepared by the present invention concentrated, dry and make the step of capsule: the operation that above-mentioned steps is concrete is: Chinese medicine extract or Chinese drugs agentia are-0.07MPa at pressure; temperature 80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 55 DEG C of dryings; dried particles being loaded the material that frequency is 606THz, wavelength is 490nm is in the blue capsule shells of hydroxypropyl emthylcellulose (HPMC), and each capsule loads medicine 0.5g.
Embodiment 2
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 3g, Herba Schizonepetae 5g, Herba Artemisiae Sieversianae 7g, Ramulus Cinnamomi 6g, Ramulus et Folium Mussaendae Pubescentis 5g, Rhizoma Arisaematis 5g, Radix Curcumae 4g, Semen Persicae 12g, Radix Glycyrrhizae 9g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 23g, Radix Astragali 24g, Rhizoma Atractylodis Macrocephalae 18g, Herba Leonuri 22g, Radix Paeoniae Alba 17g, Rhizoma Pinelliae 18g, Radix Salviae Miltiorrhizae 14g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 1 time of Traditional Chinese drug mixture weight 9 times, carries 3 hours at every turn and obtain Chinese medicine extract.
The Chinese medicine extract that embodiment 2 method is prepared by the present invention concentrated, dry and make the step of capsule: the operation that above-mentioned steps is concrete is: Chinese medicine extract or Chinese drugs agentia are-0.07MPa at pressure; temperature 80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 45 DEG C of dryings; dried particles being loaded the material that frequency is 630THz, wavelength is 479nm is in the blue capsule shells of hydroxypropyl emthylcellulose (HPMC), and each capsule loads medicine 0.5g.
Embodiment 3
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 3g, Herba Schizonepetae 5g, Herba Artemisiae Sieversianae 7g, Ramulus Cinnamomi 6g, Ramulus et Folium Mussaendae Pubescentis 5g, Rhizoma Arisaematis 5g, Radix Curcumae 4g, Semen Persicae 12g, Radix Glycyrrhizae 9g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 23g, Radix Astragali 24g, Rhizoma Atractylodis Macrocephalae 18g, Herba Leonuri 22g, Radix Paeoniae Alba 17g, Rhizoma Pinelliae 18g, Radix Salviae Miltiorrhizae 14g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 2 times of Traditional Chinese drug mixture weight 8 times, carries 2 hours at every turn and obtain Chinese medicine extract.
The Chinese medicine extract that embodiment 3 method is prepared by the present invention concentrated, dry and make the step of capsule: the operation that above-mentioned steps is concrete is: Chinese medicine extract or Chinese drugs agentia are-0.07MPa at pressure; temperature 80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 45 DEG C of dryings; dried particles being loaded the material that frequency is 400, wavelength is 620nm is in the red capsule shell of hydroxypropyl emthylcellulose (HPMC), and each capsule loads medicine 0.5g.
Embodiment 4
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 3g, Herba Schizonepetae 5g, Herba Artemisiae Sieversianae 7g, Ramulus Cinnamomi 6g, Ramulus et Folium Mussaendae Pubescentis 5g, Rhizoma Arisaematis 5g, Radix Curcumae 4g, Semen Persicae 12g, Radix Glycyrrhizae 9g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 23g, Radix Astragali 24g, Rhizoma Atractylodis Macrocephalae 18g, Herba Leonuri 22g, Radix Paeoniae Alba 17g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 2 times of Traditional Chinese drug mixture weight 8 times, carries 2 hours at every turn and obtain Chinese medicine extract.
Embodiment 5
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 3g, Herba Schizonepetae 5g, Herba Artemisiae Sieversianae 7g, Ramulus Cinnamomi 6g, Ramulus et Folium Mussaendae Pubescentis 5g, Rhizoma Arisaematis 5g, Radix Curcumae 4g, Semen Persicae 12g, Radix Glycyrrhizae 9g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 23g, Radix Astragali 24g, Rhizoma Atractylodis Macrocephalae 18g, Herba Leonuri 22g, Radix Paeoniae Alba 17g, Rhizoma Pinelliae 18g, Radix Salviae Miltiorrhizae 14g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 2 times of Traditional Chinese drug mixture weight 8 times, carries 2 hours at every turn and obtain Chinese medicine extract.Step 3, adds the water extract Chinese drugs agentia (add the water extraction 3 times of Traditional Chinese drug mixture weight 10 times, carry 3 hours at every turn) of Radix Rehmanniae and Fructus Schisandrae Chinensis in Chinese medicine extract; The weight ratio of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 1:6; The weight of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 8g.
The Chinese drugs agentia that embodiment 5 method is prepared by the present invention concentrated, dry and make the step of capsule: the operation that above-mentioned steps is concrete is: Chinese drugs agentia is-0.07MPa at pressure; temperature 80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 45 DEG C of dryings; dried particles being loaded the material that frequency is 500, wavelength is 590nm is in the orange capsule shells of hydroxypropyl emthylcellulose (HPMC), and each capsule loads medicine 0.5g.
Embodiment 6
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 3g, Herba Schizonepetae 5g, Herba Artemisiae Sieversianae 7g, Ramulus Cinnamomi 6g, Ramulus et Folium Mussaendae Pubescentis 5g, Fructus Schisandrae Chinensis 5g, Radix Curcumae 4g, Semen Persicae 12g, Radix Glycyrrhizae 9g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 23g, Radix Astragali 24g, Rhizoma Atractylodis Macrocephalae 18g, Herba Leonuri 22g, Radix Paeoniae Alba 17g, Rhizoma Pinelliae 18g, Radix Salviae Miltiorrhizae 14g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 2 times of Traditional Chinese drug mixture weight 8 times, carries 2 hours at every turn and obtain Chinese medicine extract.Step 3, adds the water extract Chinese drugs agentia (add the water extraction 2 times of Traditional Chinese drug mixture weight 6 times, carry 2 hours at every turn) of Radix Rehmanniae and Fructus Schisandrae Chinensis in Chinese medicine extract; The weight ratio of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 1:4; The weight of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 6g.
The Chinese drugs agentia that embodiment 6 method is prepared by the present invention concentrated, dry and make the step of capsule: the operation that above-mentioned steps is concrete is: Chinese drugs agentia is-0.07MPa at pressure; temperature 80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 45 DEG C of dryings; dried particles being loaded the material that frequency is 500, wavelength is 590nm is in the orange capsule shells of hydroxypropyl emthylcellulose (HPMC), and each capsule loads medicine 0.5g.
Embodiment 7
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 2g, Herba Schizonepetae 6g, Herba Artemisiae Sieversianae 5g, Ramulus Cinnamomi 7g, Ramulus et Folium Mussaendae Pubescentis 5g, Rhizoma Arisaematis 6g, Radix Curcumae 4g, Semen Persicae 15g, Radix Glycyrrhizae 5g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 25g, Radix Astragali 15g, Rhizoma Atractylodis Macrocephalae 25g, Herba Leonuri 15g, Radix Paeoniae Alba 20g, Rhizoma Pinelliae 10g, Radix Salviae Miltiorrhizae 20g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 2 times of Traditional Chinese drug mixture weight 8 times, carries 2 hours at every turn and obtain Chinese medicine extract.Step 3, the water extract adding Radix Rehmanniae and Fructus Schisandrae Chinensis in Chinese medicine extract obtains Chinese drugs agentia (add the water extraction 2 times of Traditional Chinese drug mixture weight 6 times, carry 2 hours at every turn); The weight ratio of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 1:2; The weight of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 11g.
The Chinese drugs agentia that said method is prepared by the present invention concentrated, dry and make the step of capsule: the operation that above-mentioned steps is concrete is: Chinese drugs agentia is-0.07MPa at pressure; temperature 80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 55 DEG C of dryings; dried particles being loaded the material that frequency is 630THz, wavelength is 479nm is in the blue capsule shells of hydroxypropyl emthylcellulose (HPMC), and each capsule loads medicine 0.5g.
Embodiment 8
Be used for the treatment of migrainous Chinese medicine composition, be made up of the crude drug of following weight:
Herba Bidentis Bipinnatae 3g, Herba Schizonepetae 5g, Herba Artemisiae Sieversianae 7g, Ramulus Cinnamomi 6g, Ramulus et Folium Mussaendae Pubescentis 5g, Rhizoma Arisaematis 5g, Radix Curcumae 4g, Semen Persicae 12g, Radix Glycyrrhizae 9g, Semen Platycladi 4g, Rhizoma Chuanxiong 2g, Rhizoma Acori Graminei 23g, Radix Astragali 24g, Rhizoma Atractylodis Macrocephalae 18g, Herba Leonuri 22g, Radix Paeoniae Alba 17g, Rhizoma Pinelliae 18g, Radix Salviae Miltiorrhizae 14g.
The preparation method of Chinese medicine composition, comprises the following steps:
Step 1, by each crude drug according to selected weight weighing, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture; Step 2, adds the water extraction 2 times of Traditional Chinese drug mixture weight 8 times, carries 2 hours at every turn and obtain Chinese medicine extract.Step 3, adds sodium benzoate and the potassium sorbate mixture 20g by 1:1 weight proportion in Chinese medicine extract.
Embodiment 1 to embodiment 7 capsule shells is bought from Hangzhou Sai Xu Food Machinery Co., Ltd..The capsule of different colour systems embodiment 1 to embodiment 7 prepared is tested over time in same temperature damp condition storage drug effect drug effect.
Effect example 1
1, clinical data: inventor, from 2010 to 2013, carries out clinical observation treatment to 700 routine migraineurs, wherein man 420 example, female 280 example, the age is between 18 ~ 72 years old.
2, Therapeutic Method is: oral, once-a-day, in each 120 ~ 200g of crude drug, and one after each meal; Continue 60 days.
3, curative effect determinate standard: cure: migrainous Clinical symptom and sign disappears, functional activity recovers normal.Effective: migraine clinical symptoms is clearly better or substantially disappears.Invalid: Clinical symptom and sign is without improvement.
Take embodiment 1 tcm product patient 100.Clinical effectiveness: cure 13 examples, effective 83 examples, invalid 4 examples, total effective rate is 96%.
Take embodiment 2 tcm product patient 100.Clinical effectiveness: cure 10 examples, effective 85 examples, invalid 5 examples, total effective rate is 95%.
Take embodiment 3 tcm product patient 100.Clinical effectiveness: cure 16 examples, effective 78 examples, invalid 6 examples, total effective rate is 94%.
Take embodiment 4 tcm product patient 100.Clinical effectiveness: cure 0 example, effective 55 examples, invalid 45 examples, total effective rate is 55%.Owing to having lacked the Rhizoma Pinelliae in embodiment 4, these two kinds of key components of Radix Salviae Miltiorrhizae have caused therapeutic effect to be deteriorated.
Take embodiment 5 tcm product patient 100.Clinical effectiveness: cure 14 examples, effective 80 examples, invalid 6 examples, total effective rate is 94%.
Take embodiment 6 tcm product patient 100.Clinical effectiveness: cure 16 examples, effective 79 examples, invalid 5 examples, total effective rate is 95%.
Take embodiment 7 tcm product patient 100.Clinical effectiveness: cure 15 examples, effective 78 examples, invalid 7 examples, total effective rate is 93%.
Effect example 2
1, clinical data: inventor was from 2012 to 2015, use embodiment 1,2,3,5,6 embodiment 7 to store bimestrial capsule under the same conditions and clinical observation treatment is carried out to 500 routine migraineurs, wherein man 220 example, female 280 example, the age is between 25 ~ 70 years old.
2, Therapeutic Method is: oral, 2 times on the one, one time 5, in each 120 ~ 200g of crude drug, one after each meal; Continue 60 days.
3, curative effect determinate standard: cure: migrainous Clinical symptom and sign disappears, functional activity recovers normal.Effective: migraine clinical symptoms is clearly better or substantially disappears.Invalid: Clinical symptom and sign is without improvement.
Take capsule patient 100 in embodiment 1.Clinical effectiveness: cure 14 examples, effective 83 examples, invalid 3 examples, total effective rate is 97%.
Take capsule patient 100 in embodiment 2.Clinical effectiveness: cure 12 examples, effective 83 examples, invalid 4 examples, total effective rate is 95%.
Take capsule patient 60 in embodiment 3.Clinical effectiveness: cure 5 examples, effective 43 examples, invalid 12 examples, total effective rate is 80%.
Take capsule patient 60 in embodiment 5.Clinical effectiveness: cure 6 examples, effective 40 examples, invalid 14 examples, total effective rate is 76.6%.
Take capsule patient 60 in embodiment 6.Clinical effectiveness: cure 7 examples, effective 39 examples, invalid 14 examples, total effective rate is 76.6%.
Take capsule patient 60 in embodiment 7.Clinical effectiveness: cure 8 examples, effective 37 examples, invalid 15 examples, total effective rate is 75%.
As can be seen from effect example 1 and effect example 2 result, the blue capsule shells that use material is hydroxypropyl emthylcellulose (HPMC) effectively can maintain the original effective ingredient of this Chinese medicine preparation in storage.
Tcm product prepared by effect example 3 Example 1-8 carries out storage experiment
Experimentation is as follows, is placed on by tcm product prepared by 100g embodiment 1-7 in 250ml beaker; Store in calorstat beaker being placed in 30 degrees Celsius.Observed the precipitation status of tcm product every 10 hours, and whether there is abnormal flavour impact and take.
Conventional Chinese medicinal formulae is all take in liquid form after boiling, but needs each serving with front boiling, if once boil the dose taken for twice, then medicine occurs precipitation at storage process, emits bad smell and cannot take.The present invention adds the water extract of Radix Rehmanniae and Fructus Schisandrae Chinensis in Chinese medicine extract, enabling the Chinese medicine once boiled within 2-3 days, taking, decreasing the time boiling and expend.And compared with the antiseptic of routine, the time that precipitation or abnormal flavour occur all more rearward.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. one kind is used for the treatment of migrainous Chinese medicine composition, it is characterized in that, the medicament be made up of following crude drug: Herba Bidentis Bipinnatae, Herba Schizonepetae, Herba Artemisiae Sieversianae, Ramulus Cinnamomi, Ramulus et Folium Mussaendae Pubescentis, Rhizoma Arisaematis, Radix Curcumae, Semen Persicae, Radix Glycyrrhizae, Semen Platycladi, Rhizoma Chuanxiong, Rhizoma Acori Graminei, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Leonuri, the Radix Paeoniae Alba, the Rhizoma Pinelliae, Radix Salviae Miltiorrhizae.
2. be according to claim 1ly used for the treatment of migrainous Chinese medicine composition, it is characterized in that, be made up of the crude drug of following weight portion: Herba Bidentis Bipinnatae 2 ~ 4 parts, Herba Schizonepetae 4 ~ 6 parts, Herba Artemisiae Sieversianae 5 ~ 8 parts, Ramulus Cinnamomi 5 ~ 7 parts, Ramulus et Folium Mussaendae Pubescentis 5 ~ 6 parts, Rhizoma Arisaematis 4 ~ 6 parts, Radix Curcumae 4 ~ 5 parts, 5 ~ 15 parts, Semen Persicae, 5 ~ 10 parts, Radix Glycyrrhizae, Semen Platycladi 3 ~ 4 parts, Rhizoma Chuanxiong 2 ~ 3 parts, Rhizoma Acori Graminei 15 ~ 25 parts, the Radix Astragali 15 ~ 25 parts, the Rhizoma Atractylodis Macrocephalae 15 ~ 25 parts, Herba Leonuri 15 ~ 25 parts, the Radix Paeoniae Alba 10 ~ 20 parts, the Rhizoma Pinelliae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts.
3. be according to claim 2ly used for the treatment of migrainous Chinese medicine composition, it is characterized in that, be made up of the crude drug of following weight portion: Herba Bidentis Bipinnatae 3 parts, Herba Schizonepetae 5 parts, Herba Artemisiae Sieversianae 7 parts, Ramulus Cinnamomi 6 parts, Ramulus et Folium Mussaendae Pubescentis 5 parts, Rhizoma Arisaematis 5 parts, Radix Curcumae 4 parts, 12 parts, Semen Persicae, 9 parts, Radix Glycyrrhizae, Semen Platycladi 4 parts, Rhizoma Chuanxiong 2 parts, Rhizoma Acori Graminei 23 parts, the Radix Astragali 24 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Herba Leonuri 22 parts, the Radix Paeoniae Alba 17 parts, the Rhizoma Pinelliae 18 parts, Radix Salviae Miltiorrhizae 14 parts.
4. be used for the treatment of a preparation method for migrainous Chinese medicine composition, it is characterized in that, comprise the following steps:
Step (1), after weighing according to the weight portion being used for the treatment of each crude drug in migrainous Chinese medicine composition described in Claims 2 or 3, directly each raw material of Chinese medicine of mixing obtains Traditional Chinese drug mixture;
Step (2), obtains Chinese medicine extract with water and/or alcohol extraction gained Traditional Chinese drug mixture.
5. the preparation method being used for the treatment of migrainous Chinese medicine composition according to claim 4, it is characterized in that, also comprise step (3), the Chinese medicine extract prepared to step (2) crosses 60-80 mesh sieve, and the water extract of the Radix Rehmanniae and Fructus Schisandrae Chinensis that added 60-80 mesh sieve makes Chinese drugs agentia; The weight ratio of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 1:2 ~ 6; The weight portion of described Radix Rehmanniae and Fructus Schisandrae Chinensis is 2 ~ 5% of crude drug total weight parts.
6. the preparation method being used for the treatment of migrainous Chinese medicine composition according to claim 4 or 5, is characterized in that, also comprises the concentrated, dry of Chinese medicine extract or Chinese drugs agentia and makes the step of capsule:
The operation that above-mentioned steps is concrete is: Chinese medicine extract or Chinese drugs agentia are-0.07MPa at pressure; temperature 70-80 DEG C subtracts and is concentrated into paste and granulates on granulator; cross 18 mesh sieve granulate; 45-55 DEG C of drying, loads dried particles that frequency is 606-630THz, wave-length coverage is in the blue capsule shells of hydroxypropyl emthylcellulose (HPMC) in the material of 476nm-495nm.
7. the preparation method being used for the treatment of migrainous Chinese medicine composition according to claim 4, is characterized in that, with water extraction gained Traditional Chinese drug mixture, described abstract methods is: the water extraction 1 ~ 3 time adding Chinese medicine weight 6 ~ 10 times, carries 1 ~ 3 hour at every turn.
8. the preparation method being used for the treatment of migrainous Chinese medicine composition according to claim 4, is characterized in that, described abstract methods is: the water extraction 2 times adding Chinese medicine weight 8 times, carries 2 hours at every turn.
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| CN1895438A (en) * | 2006-06-21 | 2007-01-17 | 三九医药股份有限公司 | Chinese-medicinal composition for treating cephalagia and its preparation |
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