CN104603621B - Removable many barrels and bio-sensing quantifier - Google Patents

Abstract

In certain embodiments, removable sensor box (100) includes the framework (108) with at least two wall, these walls define to accommodate the room of multiple biosensor (102), described framework has and defines hole (104) and the bottom of at least one sealing flange (106), and described framework (108) also includes the drying material that can reduce the humidity in framework (108).The size of described framework (108) may be set so that, before being inserted in blood glucose monitor by this framework, limits the plurality of sensor (102) by interference fit.

Description

Removable many barrels and bio-sensing quantifier

Cross-Reference to Related Applications

This application claims entitled " the Replaceable Multistrip submitted on May 31st, 2012 Cartridge and Biosensor Meter is replaceable " the priority of the 61/653rd, No. 603 U.S. Provisional Application, and by quoting and being included in.

Technical field

The present invention relates generally to a kind of blood glucose monitoring system for determining the concentration of glucose in blood, in particular it relates to a kind of be used in combination with blood glucose monitoring system for adjusting the sensor box of biosensor.

Background technology

Usually need quickly obtain blood sample and this blood sample is analyzed.It is relevant with blood glucose monitoring system for needing the example obtaining blood sample, and user must use this system to monitor the blood sugar level of user continually.

The erratic people of glucose concentration level is medically periodically required to their glucose concentration level of self-monitoring.Erratic glucose concentration level can be caused by many reasons, including disease, such as, diabetes.The purpose of monitoring glucose concentration level is to determine glucose concentration level, is then Tai Gao or the lowest according to glucose concentration level, and takes corrective action so that glucose concentration level returns to normal range.The failure that takes corrective action can have serious impact.When blood sugar level drops too low, so-called hypoglycemia will occur, people can become cardiopalmus, tremble, dizziness.The judgment of this people can die down, and this people finally can remain unconscious.If blood sugar level becomes the highest, then people also can become seriously to fall ill, and so-called hyperglycemia will occur.Hypoglycemia and hyperglycemia both of which are the most life-threatening emergencies.

A kind of method of the blood sugar level of monitor is to use portable hand-held blood glucose test equipment.The portability of these equipment makes no matter user which can test their blood sugar level easily at.This blood glucose measurement equipment includes gathering blood in order to the biosensor analyzed.A type of biosensor is electrochemica biological sensor.This electrochemica biological sensor includes the reagent being designed for reacting with the blood glucose in blood, and in order to produce oxidation current on the electrode in being configured at electrochemica biological sensor, this oxidation current exists direct proportional relation with the blood sugar concentration of user.Such biosensor is described in United States Patent (USP) US 5, and 120,420, US 5,660,791 and US 5, in 759,364, each of which is completely combined in this article.Another type of sensor is optical biosensor, and it comprises the reagent that the chrominance response being designed for producing user blood glucose concentration level identifies.Then the spectroscope by being incorporated in this test equipment reads this chrominance response.Such optical biosensor is described in United States Patent (USP) US 5, and in 194,393, it is incorporated herein by reference in full.

In order to check the blood sugar level of a people, use hemostix to obtain one from the finger tip of this people and bleed, be then used by biosensor and gather this blood.This biosensor being inserted in test device contacts this drop of blood.This biosensor extracts this blood in biosensor by capillarity, and electrochemical reaction subsequently is measured by testing device, and then this test device determines the blood sugar concentration in blood.Once test result shows that this biosensor just goes out of use in the display device of test device.Each new test needs new biosensor.

With reference now to Fig. 1 and 2, respectively show the packing container 30(" sensor packaging container " of test equipment 10 and biosensor 12) example.Sensor bag 30 is designed for being placed in test equipment 10.Before each test, the machinery that the acquisition zone 14 of each biosensor 12 is devices under in 10 is released, and packs through it, is extended out by groove 16, in order to gather blood sample from this test equipment 10.Test device 10 includes the slide block 18 in order to be pushed ahead by biosensor 12.In FIG, shown biosensor 12 extends out from test equipment 10.Test equipment 10 is extended in acquisition zone 14, and contact area is arranged on the other end of this biosensor 12, as illustrated in fig. 1 and 2, is retained in test equipment 10.This contact area includes the terminal that electrode is electrically connected to be positioned at the quantifier of test equipment 10, and this quantifier is for measuring the oxidation current produced on electrode by the reaction of blood glucose and reagent.This test device includes display device 20.

With reference now to Fig. 2, shown biosensor 12 is positioned in sensor packaging container 30.This sensor packaging container 30 is made up of disk 32, and this disk 32 has ten radially arranged independent compartments (blister) 34.This disk is made up of aluminium foil or laminated plastic, and it uses and bursts forth foil lid sealing, thus is kept apart with ambient humidity and other sensors by sensor.Each biosensor 12 keeps dry by being positioned at the desiccant of the desiccant compartment 37 adjoined with compartment 34.

In order to retrieve sensor, being arranged on the machinery in test equipment 10, such as blade, move downwardly through and burst forth the paper tinsel single elongated compartment 34 of entrance, finally closest to the center of separation disc 32, then the edge towards blister 34 moves radially.During do so, blade in compartment with the contact area 38(fish tail of sensor) engage.Travelling radially of blade promotes the tip of sensor to pass and bursts forth paper tinsel 36, and through the part of test equipment 10, so that the fully extended test in the acquisition zone of sensor 12 equipment 10 be ready to receive liquid testing sample, e.g., blood.To this stage, when sensor wears out from paper tinsel 36, it is essential that the band between base and the tip of sensor is through can standing the power purely of generation.The method of the sensor that this offer is ready to use is described more fully below in United States Patent (USP) US 5, and in 575,403, it is incorporated herein by reference in full.

Operate about test equipment 10 and sensor packaging container 30 and the more details of mechanical aspects are described more fully below in United States Patent (USP) US 5,575,403, US 5,630,986, US 5,738,244, US 5,810,199, US 5,854,074, US 5,856,195 and US 8, in 105,536, their full text is incorporated herein by reference.

Big area is taken with flat relevant disadvantage is that of array of this test equipment.Such flat array packing container can be accommodated the size of test equipment therein, constrain the size (that is, the quantity of sensor) of packing container, therefore be difficult to increase the quantity of the sensor of each packing container.Additionally, the quantifier of prior art and cartridge include too many parts, these parts must be replaced with each new box.Finally, sensor must be processed by user, it reduces the accuracy of reading.Therefore it provides a kind of removable box will be useful, wherein, removable part is little, and easy is on quantifier, causes relatively low use cost and higher certainty of measurement.

Summary of the invention

In certain embodiments, removable sensor box includes the framework with at least two wall, these walls define to accommodate the room of multiple biosensor, and described framework has the bottom defining hole and sealing flange, and described framework also includes the drying material that can reduce the humidity in framework.The size of described framework may be before being inserted in blood glucose monitor by this framework, is temporarily limited the plurality of sensor by interference fit.Alternatively, described sensor temporarily may be limited by the thin pearl of hot melt adhesive.

In further embodiments, blood glucose monitor includes the tank body being able to receive that replaceable sensor box.Upper strata spring may be provided with between described framework and described tank body.Described framework may be sealed for accommodating the casing of described tank body.Lower floor's spring may be provided with between described tank body and described casing.Quantifier housing may seal the top of described framework.

In certain embodiments, replaceable sensor box potentially includes housing, is arranged in described housing for receiving the framework of multiple biosensor, and drives the spring of the plurality of biosensor.Possible configuration and arrangement have bar sorter, in order to the top slide along described framework, in order to launch top biosensor from the plurality of biosensor.Described blood glucose monitor may be additionally included in the receiving channel bottom described monitor, in order to receive the sample being positioned on biosensor.At least one electrode possible configuration in described case top is connected to the biosensor of bar sorter with being used for contacting.Other changes potentially include for attaching the lid to the arm on bar sorter, so that the motion of described lid drives described bar sorter.

Accompanying drawing explanation

The various embodiments of presently disclosed distribution system are disclosed referring to the drawings:

Fig. 1 is the schematic cross-section of the test equipment of prior art；

Fig. 2 is the schematic cross-section of sensor packaging container foil lid removed of prior art；

Fig. 3 A-E is the replaceable cartridge according to one embodiment of the present of invention and the schematic cross-section of its use in quantifier；

Fig. 3 F is the schematic cross-section of the alternative box with hoistable platform according to an alternative embodiment of the invention；

Fig. 4 A and 4B is the perspective view of the sensor box with sorter according to one embodiment of the present of invention；

Fig. 4 C and 4D is the schematic cross-section of the box shown in Fig. 4 A；

Fig. 5 A-D is the perspective view of the blood glucose monitor according to one embodiment of the present of invention and the sensor box being arranged in this monitor；

Fig. 6 A-C is the perspective view of the blood glucose monitor according to an alternative embodiment of the invention and the sensor box being arranged in this monitor；

Fig. 7 A-C is the perspective view of the blood glucose monitor according to the third embodiment of the present invention and the sensor box being arranged in this monitor；

Fig. 8 A-C is the perspective view of the blood glucose monitor according to the fourth embodiment of the present invention and the sensor box being arranged in this monitor；

Fig. 9 A-C is the perspective view of the blood glucose monitor according to the fifth embodiment of the present invention and the sensor box being arranged in this monitor；

Figure 10 A-C is the perspective view of the blood glucose monitor according to the sixth embodiment of the present invention and the sensor box being arranged in this monitor；

Figure 11 A and 11B is the perspective view of the tank body of the slide block according to an alternative embodiment of the invention and association；

Figure 11 C and 11D is the perspective view of the tank body of the slide block according to an alternative embodiment of the invention and association；

Figure 12 A is the schematic cross-section of the replaceable cartridge with anti-clogging function according to one embodiment of the present of invention；

Figure 12 B is the side schematic view of the replaceable cartridge with feedback characteristics according to one embodiment of the present of invention；

The schematic cross-section of the lid of an embodiment of invention according to Figure 13 A and 13B；

Figure 14 A and 14B is the rear end schematic diagram with the replaceable cartridge processing compartment according to one embodiment of the present of invention and schematic cross-section；

Figure 15 A-C is the schematic diagram of the replaceable cartridge with contraction spring according to one embodiment of the present of invention.

Hereinafter with reference to accompanying drawing, various embodiments of the present invention are illustrated.It is to be appreciated that these accompanying drawings depict only some embodiments of the present invention, therefore should not be taken as limiting the scope of the present invention.

Detailed description of the invention

With reference now to Fig. 3 A, which show according to an embodiment of the invention for storing multiple biosensor 102(such as, the biosensor 12 in conjunction with described in Fig. 1 and 2) sensor box 100.Sensor 100 provides environment sealing, generally moistureproof for storing multiple biosensors 102.An embodiment according to sensor box 100, multiple biosensors 102 are stacked, as shown in Figure 3A in the way of generally putting on the other side by one.In this configuration, the outer rim of biosensor 102 alignment perpendicular to one another.Generally, in use, the sensor box 100 from neighbouring sealing flange 106 distributes sensor 102.Sealing flange 106 may be grouped into by the single continuous print radially protruding part of the circumference around drying material 108, or potentially includes two or more independent sector.For a user, compared to bottle, provide sensor more convenient in box.First, this box is that sensor provides storeroom in low-humidity environment, and allows less, comparatively cheap sensor, uses minimum operation, it is common that by mobile bar, can be increased in quantifier by these sensors.

The biosensor 102 stacked and drying material 108 vapor communication being arranged in sensor box 100.The inside of tank body 250 is maintained at suitable humidity level by drying material 108, so that the reagent material being arranged in biosensor 102 will not affect adversely before use.The form of drying material 108 is pouch, ball material, PUR, the shape moulded or can be with other forms being easily provided in sensor box 100.Increase enough desiccant and protect service life, but not necessarily increase the shelf life of box.The cover foil being dried or other packing containers may be needed for extra protection against the tide.Though shown drying material 108(Fig. 3 A) towards the part setting of the side of sensor box 102 and bottom, according to the alternative embodiment of sensor box 100, drying material 108 can be actually disposed in sensor box 100 Anywhere.The amount of this drying material 108 being positioned in sensor box 100 will depend upon which that sensor box 100 is internal and maintains the amount needed for drying regime.A kind of 13x synthesis of molecular sieve that can produce with the Multisorb technology company that the type of commercially available drying material in one embodiment of the invention is New York, United States Buffalo city, can be to be the forms such as powder, granule and pearl.

Sensor box 100 is made up of rigidity or semi-rigid material (as formed the plastics of framework).This material can be moistureproof.Each biosensor about 0.5 inch (about 12.7mm) is long, and about 0.03 inch (about 0.76mm) is thick, and about 0.2 inch (5.08mm) is wide.The size of the inside of sensor box 100 is only slightly larger than the length and width of biosensor 120, to allow biosensor 102 can vertically move (as described below) in sensor box but can not swinging (as shown in Figure 3A), the stacking of biosensor 102 therefore can be maintained.Such as, according to an embodiment of sensor box 100, this sensor box 100 has the inner width W of about 0.52 inch (about 13.21mm), and the internal depth (as shown in Figure 3A) of about 0.22 inch (about 5.59mm).For being suitable to accommodate the embodiment of the sensor box of 50 sensors, internal height H may be about 2.25 inches (about 57.15mm).This internal height H can be changed according to sensor box 100 optional embodiment, thus adapts to the number that biosensor 102 is increased or decreased.

In certain embodiments, the open top of sensor 100 may deliberately have and biosensor 102 slightly different size, cause a small amount of magnitude of interference, this contributes to during generating, and when this sensor box 100 is written in quantifier, allow biosensor 102 keep fixing, be described below.

The framework of box 100 potentially includes the wall for accommodating biosensor 102.In at least some example, this framework potentially includes two relative walls, has the edge of two openings between the two wall.Alternatively, this framework potentially includes three or four walls.As shown in Figure 3A, the framework of sensor box 100 may also include the hole 104 being positioned at the bottom of box.Hole 104 is configured to opening, hole or the hole of any executor's (as shown in Figure 3 C) being able to receive that form of springs, below will be described in detail.Hole 104 provides a passage, and by this passage, biosensor can be pushed up in box 100.It is understood that by the single hole 104 of Fig. 3 A distance explanation, it is also possible in this framework, form multiple hole 104.Additionally, hole 104 need not be arranged on the middle part of framework, it is also possible to be arranged on corner or the edge of framework.

Sensor box 100 can form described single assembly, and packaged to sell separately.Some sensor storage bottles provide damp-proof layer, desiccant and sealing, but also need to the additional components relevant to the delivery process of sensor, such as, the executor of lifting spring form, this executor needs to release biosensor the entrance cave, top of the array of sensor stack.Parts extra in box may increase nonrecurring charge.

In contrast, the embodiment of sensor box 100 only includes the minimum parts needed for box system reliable operation, and this system is to provide the framework (not having six faces) of sufficiently dry agent for expected service life and sealing.The necessary remainder of blood glucose monitor running can be formed as a part for reusable quantifier.In this way, it is possible to reduce the cost of the removable sensor box 100 being intended for single use.

Fig. 3 B illustrates the sensor box 100 being loaded into quantifier housing 200.Quantifier housing 200 potentially includes the taper accessory 204 that will contact with sealing flange 106.In loading process, the taper accessory 204 in quantifier housing 200 engages with sensor box 100, and by allowing biosensor 102 can freely movably make this sensor box 100 deform.Alternatively, taper accessory 204 or other accessories may be used for depressing box lock, otherwise stop biosensor to drop out.As shown in Figure 3 B, quantifier housing 200 and the sensor box 100 of assembling define isolation channel 202, and this isolation channel 202 will allow the independent expansion of biosensor 102.In this way, the most only launch a biosensor 102, decrease interference during assembling.

Tank body 250 and casing 260 may be coupled to quantifier housing 200, as shown in Figure 3 C.Waterproof tank body 250 can be arranged in quantifier casing 260, and is configured in this casing 26 slide.Tank body 250 or casing 260, or both of which is configurable to include arrestment mechanism, so that tank body 250 will not separate from casing 260.The executor of upper strata spring 270 form can be arranged in tank body 250, and the biosensor 102 of the hole 104 arrival driving through sensor box 100.A pair lower floor's spring 272 can be provided with between tank body 250 and casing 100.Along with box 100 is advanced in tank body 250 and casing 260, biosensor 102 is pushed up to the delivery surface of quantifier housing 200 by upper strata spring 270.Lower floor's spring 272 combines casing 260 and oppresses tank body 250 crush seal flange 260 and housing 200, in order to create the environment of sealing in tank body 250.Tank body is shifted onto on sealing flange 106 by the lower floor's spring 272 in casing 250, and this sealing flange 106 is clipped between tank body 250 and quantifier 200, is sealed in dry environment by biosensor 102.In one embodiment, the elastic force of lower floor's spring 272 can be higher than the elastic force of upper strata spring 270 to connect together tank body 250, flange 106 and housing 200 in sealing structure.This be assembly static or storage position.It is understood that upper strata spring 270 and lower floor's spring 272 can each include single spring.Or there are multiple springs of identical or different spring constant.Except the upper and lower spring, executor can include other elements upwards transmitted by biosensor towards feed mechanism, such that it is able to use this biosensor.Such as, executor potentially includes the Manual lifting platform 195 being arranged on below lowermost biosensing device, and this hoistable platform stretches out, as illustrated in Figure 3 F from the hole 104 of the side of box 100.Manually this hoistable platform may be pushed up, so that biosensor 102 moves towards feed mechanism.This executor potentially includes other for transmitting the displacement of biosensor or non-displacement component.

As shown in Fig. 3 C-3E, it is possible to use single biosensor 102 is released sensor box 102 by push rod 300.As shown in Figure 3 D, close along with push rod 300, tank body 250 is pushed away slightly downward, pressure of releasing from the sealing flange 106 of box 100.When push rod 300 is pushed further into, as shown in Figure 3 D, the shoulder of this push rod contact seals, and tank body is lifted remove.Isolation channel 202 ensure that an only one of which biosensor 102 is pushed by push rod 300.

Fig. 4 A illustrates the second embodiment of the sensor box 400 for storing multiple biosensor (not shown).Sensor box 400 provides environment sealing, generally moistureproof for storing the plurality of biosensor.Box 400 can be made up of rigidity or semi-rigid material (as formed the plastics of framework).Thermoplastic is included for forming the common used material of box 400.In the present embodiment, box 400 shape is generally elliptical, however, it is possible to use the most required shape.Unlike box 100, sensor box 400 does not include bottom opening, is therefore arranged on the biosensor in sensor box 400 completely and atmospheric isolation, until this biosensor is ejected.Therefore box 400 can serve as independent box, is used alone after packaging, or box 400 can be incorporated directly in quantifier.When the independent box that box 400 is used as that individual consumer uses, box 400 allows personal user to store and distributes biosensor.The size and shape of box 400 allows user to be held in the palm of the hand of this user by box 400, it is also possible to this box 400 is put into the pocket of user.Box 400 also allows for user by liquid sample storage on a biosensor, and is placed in quantifier by this biosensor, it is not necessary to the biosensor that physical contact or touch are stored therein.Natural, as compartmentalized box for holding assorted fruits and candies 400 is included in the design of test sensor (discussing in the examples below), biosensor physically can be released from box 400 and be placed in tester measuring device by user.

According to an embodiment, multiple biosensors be generally put on the other side by one in the way of push away and put.Each biosensor has the first edge 413 and the second edge 415, and this first and second edge 413,415 is in alignment with each other.Sensor box 400 includes the tank body 430 being arranged in casing 440.Sensor box 400 is with the difference of box 100, and box 400 includes the cap body part 410 with integrated sorter 425.Sorter 425 is configurable to slide along cap body part 410 level in orbit.The edge of sorter 425 is also configured as being connected with biosensor or engaging, in order to biosensor is released box 400, below it will be carried out more thorough explanation.

Fig. 4 B-4C illustrates that the sensor box 400(not having casing 400 does not the most include biosensor).As shown in Figure 4 C, multiple sensors 412 are supported in tank body 412 by base 452, the top 458 of deflection sensor box 400.Spring 470 can drive base 452 and biosensor to the top of the box 400 near sorter 425.Can also use alternative mechanism that base 452 and/or biosensor 412 are advanced to the top of box 400.For example, it is possible to pawl-and-gearing mechanism or metering device are brought in box, with providing moving upward of biosensor 412.It is similar to.The U.S. Patent application US 13/730 of entitled " the many barrels " that be similar to December in 2012 submission on the 28th, the allotter of the design disclosed in 436 can be utilized, herein by quoting, this application is included.Sensor box 400 is also possible that the protection cap (not shown) being arranged on above cap body part 410, in order to protect sorter 425 from damage during storage or loading.

Fig. 4 C and 4D is the schematic cross-section of the tank body 400 of the biosensor 412 wherein with stacking.The shown bar sorter 400 first biosensor 412A near the top being positioned at biosensor 412 heap.Bar sorter 400 includes protuberance 460, and the height HF at the edge 462 of this protuberance 460 is slightly lower than the height HB of biosensor 412A.In other words, the height HB of biosensor 412A should be slightly larger than the height HF of protuberance 460.Such as, if the height HB of biosensor 412A is 0.43mm, the height HF of protuberance 460 can be slightly lower than 0.43mm, such as, for 0.34mm.It is understood that this enforcement only provides an example, however, it is possible to use the test strip of any size.In such alternative embodiment, biosensor also will have the protuberance 460 that height HF is slightly lower than the height HB of biosensor.In this alternative embodiment, the height HB scope of biosensor can be between 0.30mm to 0.50mm, and protuberance 460 corresponding height HF can but be not restricted to that such scope between 0.29 to 0.49.

In use, user will open or removable cover is to expose sorter 425.Sorter 425 can slide in X-direction level, and therefore the edge of protuberance 460 engages with the edge 413 of test strip 412A.When sliding on sorter 425 X in the horizontal direction, biosensor 412 moves transversely across the top of the residue biosensor in heap.First edge 413 of biosensor 412 is moved into exit passageway 482 by sorter 425, and enter the opening 484 of tank body 430, so, first and second edges 413 of biosensor 412A, 415 no longer align or conllinear with the first and second edges 413,415 remaining biosensor in heap.Once sorter moves the length (Fig. 4 A) of top rail 411, and the first edge 413 of biosensor is by free or unsettled.Second edge 415 of biosensor 412A is maintained in exit passageway 482, it is allowed to user places liquid sample on biosensor 412.Although sorter the most only pushes away a sensor, but frictional force can also drag forward adjacent sensor.The limitation in height of opening 484 only one of which sensor can be pushed forward and be pulled to outside the opening of box.Then, box 400 can be moved by user towards tester measuring device (not shown), and is placed between biosensor 412A in tester measuring device, it is not necessary to touches, processes or contact biosensor 412A.Then, sorter 425 may be returned to its initial position by user, and closure caps, storage sensor box 400 is to use later.

Fig. 5 A-D illustrates the 3rd embodiment of the equipment including the sensor box 500 being arranged in blood glucose monitor.Sensor box 500 is similar to sensor box 400, except sensor box 500 can be used together with blood glucose monitor 550.Blood glucose monitor 550 potentially includes the c-type chamber being located in monitor of the shape of 500 in box, and for biosensor 502 being received the receiving slit 560 of the inside of monitor.In at least some example, each sensor box 500 includes the coding being positioned at the bottom of box.This coding can be read to determine the brand of the biosensor used, type or kind by blood glucose monitor 550.The difference manufactured due to biosensor, this coding allows blood glucose monitor automatically can calibrate according to the biosensor used.In other embodiments, each single biosensor includes for being calibrated, the coding that can be read by blood glucose monitor 500.Blood glucose monitor 550 can also include LCD display 590 and multiple functional keys (that is, power supply, display setting, biosensor selection etc.).This blood glucose monitor 550 also includes button 595, this button 595 can be in order to change the setting of display 590, such as contrast and/or color, in order to open or close this equipment, or in order to check this equipment whether normal operation, as checked battery electric quantity, and switch between pattern, or adjust for various test strip.

In use, user can open lid 580 by lid 580 being climbed over hinge 578 at the top of blood glucose monitor 550, in order to exposes slip sorter 525.Then, user can receive biosensor 502 at the square upward sliding sorter 525 of arrow " B1 " through the top of quantifier from box 500.Blood sample can be placed on biosensor 502, and, the biosensor of this sampling be directed into receiving slit 502, in order to obtains the test result about blood glucose on display 590.

Fig. 6 A-C further illustrates another embodiment of the blood glucose monitor 650 with sensor box 600.Sensor box 600 may look like any sensor box discussed above, and can include the sorter 625 for driving biosensor 602.Optional cap 680 can also be included, in order to protection sorter 625 and the top of assembly.

As shown in Figure 6B, blood glucose monitor 650 can include the electrode 615 contacting biosensor with measuring relevant blood glucose information.Compared to the embodiment above with reference to Fig. 5 A-5D, blood glucose monitor 650 can contact biosensor 602 without user and be used.On the contrary, the lid 680 on the possible hinge-opening 678 of user, at the square upward sliding sorter 625 of arrow " B2 ", thus skid off biosensor 602.Blood sample can be placed on biosensor 602, and uses sorter 625, is slipped back in blood glucose monitor 650 by biosensor 602 with the direction that arrow " B2 " is contrary.Electrode 615 may contact biosensor 602, can obtain test result from display 690.Therefore, user is without contacting biosensor 602, and this causes more accurate result.

In at least some example of the present embodiment, other parts of lid 680 and this equipment can be separable, and being connectable to blood glucose monitor 650 or any side of sensor box 600, so, this equipment can be used by the user of dexterous user and lefthanded simultaneously.In such embodiments, two hinges 678 can be arranged on any side of sensor box 600, and so, lid 680 can connect or pivot around arbitrary hinge.The symmetry of this equipment allows simple conversion between dexterous structure and dexterous structure.

In another embodiment, as figures 7 a-c, a kind of automanual blood glucose monitor 750 is illustrated.Except cap 780, other are similar to blood glucose monitor 650 to this blood glucose monitor 750.In this example, cap 780 is connected to the back side of blood glucose monitor 750, and the saddle 725 being connected on sensor box 700 by ribbon 732 by hinge 778, so, opening of lid 780 can also promote saddle 725 to launch biosensor 702, as shown in figures 7 b and 7 c.In at least some example, lid 780 can also be connected to slide block 725 by arm 735.As shown in figures 7 b and 7 c, by opening lid 780, biosensor 702 is pushed out, and is in the position that can place blood sample thereon.Close lid 780 and mobile slide block 725 is returned to its initial position.

Fig. 8 A-C, 9A-C and 10A-C illustrate the embodiment of several changes of the present invention.Fig. 8 A-C illustrates passing and the embodiment of re-orientation of sensor box 800.Sensor box 800 may look like the sensor box shown in Fig. 4 A and 4B, and includes above with respect to any element described in embodiment.Such as, as shown in Figure 8 A, sensor box 800 includes being connected to, by hinge 878, the casing 860 that has on the lid 880 of safety 881.Sensor box also includes sorter 825 and spill spin block 806.In order to use sensor box 800, lid 880 can be opened to expose sorter 825 by lid 880 is climbed over hinge 878 by user.Sorter 825 can be used to be released by biosensor 802, and lid 880 can be closed.Spill spin block 806 may be coupled to cover 880, so, closes lid 880 and makes spill spin block 806 rotate in the direction of arrow " R ", expose biosensor 802 by the safety 881 of lid 880.Therefore, the second position readjusted by biosensor 802, and this makes some users be readily appreciated that.

In Fig. 9 A-C, distance illustrates a kind of embodiment having and automatically passing, and it includes spring loaded propeller.As shown in Figure 9 A, lid 980 is pushed upwardly, and lid 980 is connected to slide block 925 by the ribbon 932 of spring push-rod form.The closedown of lid 980 causes spring push-rod by biosensor 902 out and through the front portion of equipment.This concept is similar to the design of Fig. 7 A-C, and except biosensor 902 is by the mobile front portion passing the equipment 900 relative with hinge 932, and when covering 980 closedown, biosensor 902 is unfolded.

Figure 10 A-C illustrates that be similar in Fig. 8 A-C passes and the embodiment of re-orientation.In the present embodiment, sensor box 1000 includes articulated lid 1080, lid 1080 opening as shown in Figure 10 B.When cover 1080 closedown time, sorter (not shown) makes biosensor 1002 push ahead, and use spill spin block (also not showing) by biosensor 1002 reorientation so that this biosensor 1002 towards user advance.Therefore, using above-mentioned spill spin block, biosensor by reorientation, and can pass to user with each face of various angles and sensor box 1000.Except these embodiments, other several characteristics of description can increase to any described sensor box or quantifier to facilitate the reliability using and increasing product.Such as, when using sensor box or quantifier, when slide block or sorter are part circulations, it may occur however that fault.Specifically, user may make slide block move forward to engage with biosensor, and by this biosensor partly towards the outside propelling of equipment.But, if the user while stop this slide block before completing forward stroke, and return it to original position, then this slide block may engage with the second biosensor.In certain embodiments, this equipment is configured to once deliver a biosensor.Therefore, during when two biosensors while attempt to the groove going out box stretches out, moving forward of this slide block may be hindered.This slide block returns to original position be likely to be due to the joint of itself and extra biosensor and aggravate this problem.

Additionally, single " knuckle ", bending or damage biosensor may result in blockage in the groove of box.Once a biosensor is stuck in groove, and other biological sensor may also be stuck.In order to solve the blocking of biosensor, characteristics more explained below.These characteristics can in conjunction with or be used in combination with above-mentioned any embodiment.

Figure 11 A is the perspective view of the slide block 1122 with sorter 1125 and claw 1126 for engaging with biosensor.Sorter 1125 can be formed in any structure illustrated above.Claw 1126 can be formed by horizontal flexible ratchet wheel material.When increasing that claw 1126 (such as, the one side identical with sorter) is used in combination with the tank body 1120 of Figure 11 B below slide block 1122, the problem that blocking can be alleviated.Tank body 1130 includes the ratchet 1132 extended from original position 1136 to final position 1138, and based on this ratchet 1132, claw 1126 can move.Tank body 1130 also includes being parallel to the smooth track 1134 that ratchet 1132 extends.

In use, the claw 1126 of slide block 1122 can slide along the ratchet 1132 of tank body 1130.Claw 1126 and ratchet 1132 are configured to this claw 1126 and can not may only move in the opposite direction in direction of advance on this ratchet 1132.Once claw 1126 has travelled forward and has crossed this ratchet, and claw 1126 can be driven is moved down into smooth track 1134.Archetype display track 1132 is tapered to order about claw to track 1134 from one end, uncertain this whether must be in the final position in arrow " P " direction.Therefore, claw 1126 and slide block 1122 can move back into original position 1136 from final position 1138 on smooth track 1134.In this way, slide block 1122 must complete the whole stroke on ratchet 1132 before correcting action, thus produces less biosensor blocking.

One deformation of the present embodiment is as shown in Figure 11 C and 11D.Being similar to the embodiment of figure 11 above A-B, the present embodiment includes the slide block with sorter 1125.Replacing the claw 1128 in the rear end of slide block 1122, the slide block of Figure 11 C includes flexible stop tab 1127.This stop tab 1127 guides at tank body 1130 on ratchet 1132, and as shown in Figure 11 D, it is included in a pair pocket 1142 on original position 1136 and final position 1138, and this instead of smooth track to pocket 1142.Pocket 1142 can form sufficiently large space, thus allows the reverse in flexible stop tab 1127 direction.

Stop tab 1127 can on ratchet 1132 from original position 1136 to final position 1138 forward slip, but can not move in opposite direction.Stop tab 1127 once arrives the pocket 1142 being positioned at final position 1138, it can in pocket 1142 torsional direction, and again from ratchet 1132 return.Therefore, in this way, stop tab 1127 is only reversible in pocket 1142, and slide block 1122 only (such as, being positioned at the two ends of pocket 1142 at ratchet 1132) conversion direct of travel in circulation.Therefore, this change also forces slide block 1122 to complete the whole stroke on ratchet 1132 before correcting action, thus produces less biosensor blocking.

But Figure 12 A is to be similar to the replaceable cartridge of Fig. 3 B has the schematic cross-section of the replaceable cartridge of anti-clogging characteristic.Sensor box 100 can be loaded in quantifier housing 200.Quantifier housing 200 potentially includes the taper accessory 204 of contact sealing flange 106.In loading process, the taper accessory 204 in quantifier housing 200 engages with sensor box 100, and by allowing biosensor 102 can freely movably make this sensor box 100 deform.Sensor box 100 may also include the deflector 1202 being connected on hinge 1204.Deflector 1202 can rotate up in the side of arrow " O " around hinge 1204, thus opens and provide the approach of the inside entering sensor box 100.Therefore, when the biosensor of deformation or multiple biosensor 102 can not the most out time, deflector 1202 can create the occasional passage of more than one biosensor, in order to clear blocking.

But Figure 12 B is to be similar to the replaceable cartridge 400 shown in Fig. 4 B has the schematic cross-section of the replaceable cartridge of feedback function.Feedback function 1024 to be formed in the recess form below sorter 425 and cap body part 410, and can provide a user with patter sound or the sense of touch feedback of position about sorter 425.Therefore, user, it can be appreciated that this sorter 425 has arrived at the terminal of forward stroke or backstroke, reduces the danger of biosensor blocking.Except recess, it is to be understood that feedback function 1024 can also include raised line, projection, recess or other functional parts allowing sorter 425 to provide sense of touch to feed back smoothing described in example performed as described above and travel across track when.It is understood that replaceable cartridge 400 can include one, two, three, four or multiple feedback function parts 1204, and these feedback function parts 1204 can include any of above combination.

Except these characteristics, the lid of equipment can be changed further to prevent blocking and Partial Resection biosensor.Specifically, if slide block or sorter do not complete whole forward stroke, the biosensor of Partial Resection may be stayed in box.That block or Partial Resection biosensor can allow dampness access arrangement, thus damages biosensor.

Figure 13 A and 13B is the schematic cross-section of the lid 1380 according to one embodiment of the present of invention.As it can be seen, lid 1380 potentially includes the spine 1382 of the length along lid, and there is the little chamber 1384 for receiving sorter.Spine 1382 one end (such as, original position) in sorter returns to chamber 1384 is front, prevents from covering 1380 closedowns on sensor box.Therefore, spine 1382 can not allow to cover 1380 closedowns, until sorter returns to original position.This characteristic can be used alone, it is also possible to combines any characteristic disclosed above and uses.

The processing region of the biosensor for using can also be included in any embodiment illustrated above.Figure 14 A and 14B is the schematic cross-section of such a box.Replaceable cartridge 1400 is included in the process compartment 1484 in lid 1480.Process compartment 1484 to be connected with surrounding air by the treatment trough 1482 at sensor box 1400 back.Lid 1480 may be able to be opened to expose sorter recited above or slide block on hinge 1478.User can close lid 1480 after using this biosensor, and is processed in compartment 1484 by contaminated biosensor by treatment trough 1482.Processing compartment 1484 can be by other component seal any of equipment.Additionally, treatment trough 1482 can include isolating valve 1486, in order to prevent contaminated biosensor from dropping out process compartment 1484.When processing, compartment 1484 is full, or this equipment does not has biosensor, and user can process the whole equipment with contaminated biosensor.

Except ratchet with the lid of spine, characteristic can be increased automatically sorter to be retracted into original position.Figure 15 A-C is the schematic diagram of the replaceable cartridge 1500 of the contraction spring 1510 having and being connected to sorter 1525.Contraction spring 1510 potentially includes constant force spring 1525 to promote sorter 1525 to return to original position.Therefore, user can drive sorter 1525 to engage with biosensor, and promotes this sorter to resist spring force.Once user discharges this sorter 1525, and contraction spring 1510 will force sorter 1525 correcting action.In this way, it is possible to reduce engage the probability of multiple.

Although describing the present invention by reference to specific embodiment, it needs to be understood that, these embodiments merely illustrate principle and the application of the present invention.Accordingly, it would be desirable to be appreciated that, embodiment illustrated can be made many changes, it is also possible to design other arrangements, without deviating from appended spirit and scope of the invention as.

It should be appreciated that the respective dependent claims that proposes of the application and feature can by from former claim is proposed different in the way of combine.It should also be appreciated that the characteristic relevant with single embodiment can be shared with other described embodiments.

Claims (11)

1. a removable sensor box, including:

Framework, this framework has the drying material of the humidity that can reduce in this framework, and is used for accommodating multiple biological biography Sensor；And

Bar sorter, it is configured and arranged as the top slide along described framework, from described many in forward stroke Individual biosensor launches top biosensor, and in backstroke, returns to the initial bit of this sorter Putting, described bar sorter includes flexible catch, for providing the ratcheting action at the top along described framework；With And

At least one anti-clogging structure, it includes the deflector being positioned on described removable sensor box, this deflection Be partially configured to temporarily allow the biosensor of deformation or more than one biosensor leave described can be more The sensor box changed.

Removable sensor box the most according to claim 1, it is characterised in that described framework includes multiple Ratchet and parallel smooth track, described framework is configured to closely cooperate with the described claw of described bar sorter, And allow the forward stroke along described ratchet and the backstroke along described smooth track.

Removable sensor box the most according to claim 1, it is characterised in that described deflector connects On the hinge of described removable sensor box, and it is configured to rotate about the rotation of described hinge, and entrance is provided The approach of the inside of described removable sensor box.

Removable sensor box the most according to claim 1, it is characterised in that described anti-clogging structure bag Include at least one feedback arrangement.

Removable sensor box the most according to claim 4, it is characterised in that at least one feedback described Structure is configured to when described bar sorter arrives the terminal of advance or backstroke provide sense of touch feedback.

Removable sensor box the most according to claim 4, it is characterised in that at least one feedback described Structure includes the recess arranged on said frame.

Removable sensor box the most according to claim 1, it is characterised in that described sensor box also wraps Including the lid at top for covering described framework, described lid has the spine of longitudinal extension and for receiving described bar The chamber of sorter.

Removable sensor box the most according to claim 7, it is characterised in that described lid is only configured to Could close when described bar sorter is in one end of described framework.

Removable sensor box the most according to claim 7, it is characterised in that described lid define for Receive the process compartment of contaminated biosensor, and for described contaminated biosensor is inserted into Treatment trough in described process compartment.

Removable sensor box the most according to claim 1, it is characterised in that described anti-clogging structure bag Including the contraction spring being connected to described bar sorter, this contraction spring is configured to make described bar sorter return to institute State original position.

11. removable sensor boxes according to claim 10, it is characterised in that described contraction spring is Constant force spring.