CN104586379A - Method and device for outputting parameters of fetal heart rate curve - Google Patents
Method and device for outputting parameters of fetal heart rate curve Download PDFInfo
- Publication number
- CN104586379A CN104586379A CN201510031500.6A CN201510031500A CN104586379A CN 104586379 A CN104586379 A CN 104586379A CN 201510031500 A CN201510031500 A CN 201510031500A CN 104586379 A CN104586379 A CN 104586379A
- Authority
- CN
- China
- Prior art keywords
- heart rate
- fetal heart
- rate curve
- peak
- trough
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002458 fetal heart Anatomy 0.000 title claims abstract description 289
- 238000000034 method Methods 0.000 title claims abstract description 28
- 238000012544 monitoring process Methods 0.000 claims abstract description 8
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 claims description 16
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 12
- 238000005259 measurement Methods 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 3
- 238000002372 labelling Methods 0.000 claims description 3
- 230000001133 acceleration Effects 0.000 abstract description 11
- 238000012545 processing Methods 0.000 abstract description 2
- 208000031427 Foetal heart rate deceleration Diseases 0.000 description 12
- 230000001605 fetal effect Effects 0.000 description 12
- 238000012806 monitoring device Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 208000006893 Fetal Hypoxia Diseases 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 210000003754 fetus Anatomy 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000035606 childbirth Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 208000032943 Fetal Distress Diseases 0.000 description 1
- 206010016855 Foetal distress syndrome Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010069140 Myocardial depression Diseases 0.000 description 1
- 206010045451 Umbilical cord compression Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000001444 hypervagal effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/024—Measuring pulse rate or heart rate
- A61B5/02411—Measuring pulse rate or heart rate of foetuses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Pregnancy & Childbirth (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The invention is suitable for the technical field of medical signal processing, and provides a method and a device for outputting parameters of a fetal heart rate curve. The method comprises the following steps of according to an original signal collected by fetal heart monitoring equipment, generating the fetal heart rate curve; extracting the fetal heart rate curve within a specified period of time; measuring the wave peak/wave trough parameters of the fetal heart rate curve within the specified period of time; simultaneously outputting the fetal heart rate curve and the measured wave peak/wave trough parameters. The method has the advantage that the wave peaks/wave troughs in the fetal heart rate curve can be accurately identified, so the outputted fetal heart rate curve can visually and correctly display the fetal heart rate acceleration and deceleration conditions, and a medical staff can conveniently and accurately perform identification according to the outputted fetal heart rate curve, and the identifying accuracy is improved.
Description
Technical Field
The invention belongs to the technical field of medical signal processing, and particularly relates to a method and a device for outputting parameters of a fetal heart rate curve.
Background
Fetal heart rate is an important index for judging safety risk of a fetus in a uterus, and clinically, the fetal heart rate comprises the conditions of fetal heart rate acceleration and fetal heart rate deceleration, wherein the fetal heart rate acceleration accompanying fetal movement is one of important indexes for good fetal reserve, and the lack of fetal heart rate acceleration for a long time is a sign of fetal hypoxia, and at the moment, the fetal condition is determined through corresponding clinical tests and corresponding intervention measures are taken; fetal heart rate deceleration is the simplest and most effective method for determining fetal safety during the childbirth period, and in the whole progress of the labor process, approximately 50% -70% of the childbirth cases can have fetal heart rate deceleration, including early deceleration, late deceleration, variable deceleration and prolonged deceleration. Early deceleration is generally considered to be caused by pressure on fetal head and has little relation with fetal hypoxia; late deceleration is caused by hypervagal nerve hyperactivity and/or myocardial depression due to hypoxia, and occurs mainly in fetal hypoxia caused by decreased uterine-placental blood flow, placental hypofunction, and the like; the variant deceleration is mainly caused by umbilical cord compression, and fetal distress is prompted when severe variant deceleration or atypical variant deceleration occurs; prolonged deceleration suggests possible hypotension in the supine position, which requires timely finding and treatment.
Clinically, analysis and diagnosis need to be performed according to a fetal heart rate curve in a fetal heart uterine contraction monitoring (CTG) curve, and an important aspect in the process is to further draw a clinical diagnosis conclusion by identifying and analyzing peaks/troughs in the fetal heart rate curve, and analyzing information such as the number, amplitude, duration, type, relation with uterine contractions and the like of the fetal heart rate acceleration and the fetal heart rate deceleration in the fetal heart rate curve. The above analysis and diagnosis process will affect the classification of fetal heart rate curves and will also affect the final diagnostic conclusions that medical personnel make with respect to the pregnant woman and the fetus.
However, when the fetal heart rate curve is output, whether the fetal heart rate curve is displayed at a central station of a obstetrical department or displayed on a bedside machine, or printed on printing paper, due to limited space of a screen or the printing paper, the fetal heart rate curve can be compressed to different degrees, and the compression particularly causes that peaks/troughs are difficult to identify due to deformation, or partial detailed information of the peaks/troughs is hidden and cannot be accurately identified, so that acceleration and deceleration of the fetal heart rate cannot be accurately identified; meanwhile, under the condition of the prior art, a doctor can only identify the wave crest/wave trough by naked eyes, for example, the duration time of the fetal heart rate deceleration required in the definition of the extension deceleration is more than or equal to 2 minutes, and under the condition that the fetal heart rate curve is compressed and only identified by the naked eyes, the doctor cannot distinguish whether the deceleration duration time is 1 minute, 59 seconds or 2 minutes, and can only judge by experience, so that the condition of inaccurate judgment can be caused, the integral analysis result of the fetal heart rate curve by the doctor is influenced, and misdiagnosis can be caused.
Disclosure of Invention
The embodiment of the invention aims to provide a method and a device for outputting parameters of a fetal heart rate curve, and aims to solve the problem that in the prior art, the peak/trough is difficult to accurately identify because the fetal heart rate curve is compressed during output.
The embodiment of the invention is realized in such a way that a method for outputting parameters of a fetal heart rate curve comprises the following steps:
generating a fetal heart rate curve according to an original signal acquired by fetal heart monitoring equipment;
extracting the fetal heart rate curve in a specified time period;
measuring a peak/trough parameter of the fetal heart rate curve for the specified time period;
and simultaneously outputting the fetal heart rate curve and the measured peak/trough parameters.
Optionally, the measuring the peak/trough parameter of the fetal heart rate curve for the specified time period comprises:
calculating a fetal heart rate mean value H of the fetal heart rate curve of the specified time period;
generating a line segment A which is parallel to a time axis and has a vertical coordinate of H within the specified time period of the fetal heart rate curve;
generating a line segment B which is parallel to a time axis and has a vertical distance with the line segment A as a first preset threshold value L within the specified time period of the fetal heart rate curve;
extracting an intersection point of the line segment A and the fetal heart rate curve of the specified time period;
judging whether any two adjacent intersection points meet the condition that the distance between the two intersection points is larger than a second preset threshold value T and whether the fetal heart rate curve between the two intersection points has a part exceeding the line segment B, if so, acquiring the fetal heart rate curve between the two adjacent intersection points;
measuring the peak/trough parameters based on the acquired fetal heart rate curve.
Optionally, said measuring said peak/trough parameter based on said marked fetal heart rate curve comprises performing at least one of:
detecting a peak value point M of the acquired fetal heart rate curve, measuring a vertical distance DL from the peak value point M to the line segment A, and outputting the DL as the amplitude of the peak/trough;
detecting the time length DS of the acquired fetal heart rate curve, and outputting the DS as the duration of the wave crest/wave trough;
detecting a starting point N and a peak point M of the acquired fetal heart rate curve, measuring a horizontal distance DR from the starting point N to the peak point M, and determining the DR as the generation time of the wave crest/wave trough.
Optionally, the measuring the peak/trough parameter of the fetal heart rate curve for the specified time period comprises:
generating a line segment C perpendicular to a time axis in the fetal heart rate curve;
according to the detected movement instruction, the line segment C is horizontally moved and displayed at a corresponding position, so that the amplitude of the peak/trough is determined according to the intersection point of the line segment C and the peak/trough of the fetal heart rate curve.
Optionally, the extracting the fetal heart rate curve for the specified time period comprises:
receiving a selection instruction input by a user, and detecting a time period selected by the selection instruction in the fetal heart rate curve;
extracting the fetal heart rate curve for the selected time period from the fetal heart rate curves.
Optionally, the simultaneously outputting the fetal heart rate curve and the measured peak/trough parameter comprises:
generating an independent time axis in a designated area, wherein the time axis corresponds to the time axis of the fetal heart rate curve one by one in time, and the designated area comprises a blank area between the fetal heart rate curve and the uterine contraction strength curve;
marking the peak/trough parameters at the corresponding positions of the independent time axis of the designated area according to the occurrence time of the peak/trough parameters;
and simultaneously outputting the fetal heart rate curve and the labeled wave crest/wave trough parameters.
Another object of an embodiment of the present invention is to provide a device for outputting parameters of a fetal heart rate curve, including:
the generating unit is used for generating a fetal heart rate curve according to the original signals collected by the fetal heart monitoring equipment;
the extraction unit is used for extracting the fetal heart rate curve in a specified time period;
the measuring unit is used for measuring the peak/trough parameters of the fetal heart rate curve in the specified time period;
and the output unit is used for simultaneously outputting the fetal heart rate curve and the measured peak/trough parameters.
Optionally, the measurement unit comprises:
the calculating subunit is used for calculating a fetal heart rate mean value H of the fetal heart rate curve of the specified time period;
a segment A generation subunit, configured to generate a segment A parallel to a time axis and having a vertical coordinate of the H within the specified time period of the fetal heart rate curve;
a segment B generating subunit, configured to generate a segment B that is parallel to a time axis and has a vertical distance from the segment A of a first preset threshold L within the specified time period of the fetal heart rate curve;
an intersection point extracting subunit, configured to extract an intersection point between the line segment a and the fetal heart rate curve in the specified time period;
a judging subunit, configured to judge whether any two adjacent intersection points meet a condition that a distance between the two intersection points is greater than a second preset threshold T and whether a fetal heart rate curve between the two intersection points exceeds the line segment B, and if so, obtain the fetal heart rate curve between the two adjacent intersection points;
a first measuring subunit, configured to measure the peak/trough parameter based on the acquired fetal heart rate curve.
Optionally, the first measurement subunit is specifically configured to perform at least one of the following three items:
detecting a peak value point M of the acquired fetal heart rate curve, measuring a vertical distance DL from the peak value point M to the line segment A, and outputting the DL as the amplitude of the peak/trough;
detecting the time length DS of the acquired fetal heart rate curve, and outputting the DS as the duration of the wave crest/wave trough;
detecting a starting point N and a peak point M of the acquired fetal heart rate curve, measuring a horizontal distance DR from the starting point N to the peak point M, and determining the DR as the generation time of the wave crest/wave trough.
Optionally, the measurement unit comprises:
a line segment C generation subunit operable to generate a line segment C perpendicular to a time axis in the curve;
and the second measuring subunit is used for horizontally moving and displaying the line segment C at a corresponding position according to the detected moving instruction so as to determine the amplitude of the peak/trough according to the intersection point of the line segment C and the peak/trough of the fetal heart rate curve.
Optionally, the extraction unit includes:
the receiving subunit is used for receiving a selection instruction input by a user and detecting a time period selected by the selection instruction in the fetal heart rate curve;
a curve extraction subunit, configured to extract the fetal heart rate curve of the selected time period from the fetal heart rate curve.
Optionally, the output unit includes:
a time axis generating subunit, configured to generate an independent time axis in a designated area, where the time axis corresponds to a time axis of the fetal heart rate curve one-to-one in time, and the designated area includes a blank area between the fetal heart rate curve and the uterine contraction strength curve;
a labeling subunit, configured to label, according to occurrence time of the peak/valley parameter, the peak/valley parameter at a corresponding position of the independent time axis in the designated area;
and the output subunit is used for simultaneously outputting the fetal heart rate curve and the labeled wave crest/wave trough parameters.
The embodiment of the invention can accurately identify the wave crest/wave trough in the fetal heart rate curve, so that the output fetal heart rate curve can intuitively and accurately display the acceleration and deceleration conditions of the fetal heart rate, the medical staff can conveniently and accurately identify according to the output fetal heart rate curve, and the identification accuracy is improved.
Drawings
FIG. 1 is a flowchart of an implementation of a method for outputting parameters of a fetal heart rate curve according to an embodiment of the present invention;
fig. 2 is a flowchart of a specific implementation of the method S102 for outputting parameters of a fetal heart rate curve according to an embodiment of the present invention;
fig. 3 is a flowchart illustrating a specific implementation of the method S103 for outputting parameters of a fetal heart rate curve according to an embodiment of the present invention;
fig. 4 is a flowchart illustrating a specific implementation of the method S103 for outputting parameters of a fetal heart rate curve according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of the fetal heart rate curve output when the fetal heart rate is accelerated according to the parameter output method of the fetal heart rate curve provided by the embodiment of the invention;
FIG. 6 is a schematic diagram of the fetal heart rate curve output when the fetal heart rate decelerates according to the parameter output method of the fetal heart rate curve provided by the embodiment of the invention;
fig. 7 is a block diagram of a parameter output device for a fetal heart rate curve according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Fig. 1 shows an implementation flow of a parameter output method of a fetal heart rate curve provided by an embodiment of the present invention, which is detailed as follows:
in S101, a fetal heart rate curve is generated according to the raw signals collected by the fetal heart monitoring device.
The fetal heart rate monitoring device can complete the acquisition of original signals through the probe after being started, converts the acquired original signals into corresponding fetal heart rate and uterine cavity pressure data and puts the data into a specified cache region, a background program of the fetal heart rate monitoring device generates and displays a fetal heart rate curve according to the data stored in the cache region, and the generated fetal heart rate curve takes time as a horizontal coordinate and the fetal heart rate as a vertical coordinate.
In S102, the fetal heart rate curve for a specified time period is extracted.
In this embodiment, the fetal heart rate curve of the specified time period may be a fetal heart rate curve currently displayed on a screen of the fetal heart monitoring device, or may also be a fetal heart rate curve within a time period selected by a user through inputting a selection instruction in the fetal heart rate curve, specifically, a selection instruction input by the user is received, the time period selected by the selection instruction in the fetal heart rate curve is detected, and then the fetal heart rate curve of the selected time period is extracted from the fetal heart rate curve.
As an embodiment of the present invention, as shown in fig. 2, the receiving a selection instruction input by a user, and detecting a time period selected by the selection instruction in the fetal heart rate curve includes:
in S201, a start point selection instruction input by a user is received, and a first input position of the start point selection instruction in the fetal heart rate curve is detected.
In S202, an endpoint selection instruction input by a user is received, and a second input position of the endpoint selection instruction in the fetal heart rate curve is detected.
In this embodiment, a start point selection button and an end point selection button may be generated on an operation interface of the fetal heart rate monitoring device, after the start point selection button is triggered, a click operation is performed at any position in a fetal heart rate graph, and when the start point selection is completed, the position is the first input position; and after the end point selection button is triggered, clicking any position in the fetal heart rate curve graph to finish end point selection, wherein the position is a second input position.
In S203, two separators are generated at the first input position and the second input position of the fetal heart rate curve, respectively.
In S204, the time period selected in the fetal heart rate curve is determined based on the two separators.
The separator may be a line segment, or may be another form of separation mark. Taking a line segment as an example, after the selection of the starting point and the end point is completed, the system background automatically generates two line segments which are perpendicular to and intersect with the time axis on the first input position and the second input position respectively, and then the two intersection points of the line segment and the time axis are the time starting point and the time end point of the time period selected by the user respectively, so that the selection of the time period is completed.
In the process of selecting the starting point and the end point, whether a corresponding selection instruction is received within a preset time length can be judged, if yes, S203 is executed, and if not, the input of the selection instruction is continuously waited.
As another embodiment of the present invention, the receiving a selection instruction input by a user, and detecting a time period selected by the selection instruction in the fetal heart rate curve may be further implemented by: after receiving two selection instructions input by a user, respectively detecting input positions of the two selection instructions in a fetal heart rate curve, respectively generating two line segments perpendicular to a time axis at the two detected input positions, and taking a line segment between two intersection points as the time period selected in the fetal heart rate curve. In contrast to the embodiment shown in fig. 2, the present embodiment does not need to particularly determine the start point and the end point when the selection instruction input is performed, and directly takes the time period between two input positions as the selected time period. Furthermore, if a third or even further selection instruction is received, these selection instructions may be refused to be responded to, or the time period selected in the fetal heart rate curve may be determined otherwise according to a preset manner, such as according to the last two selection instructions, or according to the first selection instruction and the last selection instruction, and so on.
The embodiment can accurately and quickly complete the selection of the time period, and the generated line segment can also directly pass through the fetal heart rate curve to complete the data interception of the fetal heart rate curve, so that the fetal heart rate curve corresponding to the selected time period is extracted.
In S103, a peak/trough parameter of the fetal heart rate curve for the specified time period is measured.
Wherein the peak/trough parameters include, but are not limited to: amplitude of a peak/trough, duration of a peak/trough, or generation time of a peak/trough (including rise time of a peak and fall time of a trough). As shown in fig. 3, the S103 is implemented by:
in S301, a fetal heart rate mean H of the fetal heart rate curve for the specified time period is calculated.
And calculating based on the fetal heart rate data in the specified time period to obtain the fetal heart rate mean value H of the fetal heart rate curve in the period.
In S302, a segment a parallel to the time axis and having the ordinate of H is generated within the specified time period of the fetal heart rate curve.
In S303, a segment B parallel to the time axis and having a vertical distance from the segment a of a first preset threshold L is generated in the specified time period of the fetal heart rate curve.
In this embodiment, based on the analysis requirement for the fetal heart rate curve, if the acceleration condition of the fetal heart rate needs to be analyzed currently, the position of the generated line segment B is higher than that of the line segment a; if the deceleration condition of the fetal heart rate needs to be analyzed currently, the position of the generated line segment B is lower than that of the line segment A.
In addition, the line segment a and the line segment B may be set as a line segment group capable of moving simultaneously in a direction parallel to the time axis within the specified time period, and in the moving state, when the cursor is moved onto the line segment a or the line segment B, the cursor may be converted into a hand tool to prompt the user that the line segment a and the line segment B can be moved simultaneously at this time so as to position the line segment a and the line segment B at the most appropriate baseline positions. During the above movement, the line segment a and the line segment B must always maintain the vertical distance of L.
In S304, an intersection of the line segment a and the fetal heart rate curve for the specified time period is extracted.
In S305, it is determined whether any two adjacent intersection points satisfy that the distance between the two intersection points is greater than a second preset threshold T and the fetal heart rate curve between the two intersection points has a portion exceeding the line segment B, if so, the fetal heart rate line segment between the two adjacent intersection points is obtained.
Because the line segment A represents the fetal heart rate mean value of the fetal heart rate curve in the specified time period, an intersection point exists between the line segment A and the fetal heart rate curve, every two adjacent intersection points are sequentially judged, and whether the two adjacent intersection points meet the following two conditions simultaneously is judged:
1. whether the distance (i.e., the time length) between the two intersection points is greater than a second preset threshold T;
2. whether a part exceeding the line segment B exists in the fetal heart rate curve between the two intersection points or not is judged, wherein if the acceleration condition of the fetal heart rate is analyzed currently, whether the part higher than the line segment B exists in the fetal heart rate curve between the two intersection points or not is judged; if the current analysis shows that the fetal heart rate is in the deceleration condition, judging whether a fetal heart rate curve between the two intersection points has a part lower than the line segment B or not.
If both of the above conditions are met, a fetal heart rate curve between the two intersection points is obtained, and the fetal heart rate curve between the two intersection points may be marked, for example, the portion of the fetal heart rate curve is shown in bold.
In S306, measuring the peak/trough parameters based on the acquired fetal heart rate curve, the peak/trough parameters including: amplitude, duration, or generation time of the peaks/valleys.
Specifically, the starting point N and the peak point M of the partial fetal heart rate curve are first determined, and at least one of the following three items is performed:
1. detecting a peak value point M of the acquired fetal heart rate curve, measuring a vertical distance DL from the peak value point M to the line segment A, and outputting the DL as the amplitude of the peak/trough;
2. detecting the time length DS of the acquired fetal heart rate curve, and outputting the DS as the duration of the wave crest/wave trough;
3. detecting a starting point N and a peak point M of the acquired fetal heart rate curve, measuring a horizontal distance DR from the starting point N to the peak point M, and determining the DR as the generation time of the wave crest/wave trough.
As an embodiment of the present invention, as shown in fig. 4, S103 may also be:
in S401, a segment C perpendicular to the time axis is generated in the fetal heart rate curve.
In S402, according to the detected movement instruction, the line segment C is horizontally moved and displayed at a corresponding position, so as to determine the amplitude of the peak/trough according to the intersection of the line segment C and the peak/trough of the fetal heart rate curve.
In this embodiment, the line segment C can be regarded as the scale, and move the line segment C to form the nodical with crest/trough of the fetal heart rate curve through the removal instruction to can be according to this nodical range that measures crest/trough directly perceived, fast in scale position on line segment C. Obviously, the segment C may also be moved to form an intersection point with any position of the fetal heart rate curve according to the movement instruction, so as to measure the fetal heart rate at any position of the fetal heart rate curve.
In addition, the peak point M may be obtained according to the amplitude of the peak/trough determined by the line segment C, or may be obtained according to a built-in algorithm.
In S104, the fetal heart rate curve and the measured peak/trough parameter are output simultaneously.
In this embodiment, the output result includes the fetal heart rate curve and the peak/trough parameter measured in S103, and fig. 5 and 6 respectively show the fetal heart rate curve output schematic diagrams of the analysis of the acceleration condition and the deceleration condition of the fetal heart rate. The description will be made by taking fig. 6 as an example:
in fig. 6, the upper curve is the fetal heart rate curve in the CTG curve, the lower curve is the contraction strength curve in the CTG curve, the partial fetal heart rate curves satisfying the above two conditions are marked with bold marks, the corresponding start point N and peak point M are identified in the time range of the fetal heart rate curve of each segment of marks, meanwhile, an independent time axis is set in the space region P below the segment of fetal heart rate curve (between the fetal heart rate curve and the contraction strength curve), the time axis corresponds to the time axis of the fetal heart rate curve one by one in time, the display region of the time axis supports the same screen display or the same printing with the fetal heart rate curve, based on the time axis, the peak/trough parameters are marked at the corresponding position of the independent time axis in the blank region P, the displayed parameters correspond to the occurrence time of the parameters one by one and are proper to the CTG curve without being covered, and preventing the CTG curve data from being influenced, and finally, simultaneously outputting the fetal heart rate curve and the labeled wave crest/wave trough parameters. For example, "fall time: the identification position of 24s "coincides with the falling time period of its corresponding trough; "falling time: the identified position of 52s "coincides with the falling time period of its corresponding trough.
The output mode of S104 includes but is not limited to at least one of the following:
1. outputting the fetal heart rate curve and the measured peak/trough parameters to a storage device for storage;
2. outputting the fetal heart rate curve and the measured peak/trough parameters to a display device for displaying;
3. and outputting the fetal heart rate curve and the measured wave crest/wave trough parameters to a printing device for printing.
From this one, medical staff can conveniently look over the fetal heart rate curve that has passed through the sign in display device, perhaps look over the fetal heart rate curve that has passed through the sign that has been printed out by printing device, and the fetal heart rate curve that has passed through the sign can be stored well in storage device, shows output or printout when being convenient for follow-up needs.
Meanwhile, if the peak/trough parameters are displayed in the blank area between the fetal heart rate curve and the uterine contraction strength curve, the following technical effects can be produced: since the uterine contraction directly reflects the degree of fetal compression, the oxygen supply condition of the fetus is related to, and the insufficient oxygen supply leads to the fetal central nervous system adjusting the fetal heart rate to adapt to the environmental change, which is one of the means for the clinician to examine the fetal reserve capacity and the central nervous system adjusting capacity, the regular uterine contraction occurring in the birth process generally corresponds to the regular fetal heart rate change types, but the fetal states corresponding to different fetal heart rate change types are different definitely, for example, when the regular uterine contraction causes the fetal heart rate to generate regular early deceleration, the fetal head is just compressed and harmless, but when the regular uterine contraction causes the fetal heart rate to generate regular late deceleration, the fetal head is seriously insufficient in oxygen supply, possibly harming the fetal nervous system, and the measures need to be taken immediately for treatment. Therefore, clinically, a doctor needs to continuously analyze the correlation between the time and the amplitude of the uterine contraction and the appearance of the peak/trough by combining the time, the duration and the amplitude of the rising/falling of the peak/trough and the uterine contraction intensity in the duration, and then can analyze the corresponding type of the peak/trough, so that the peak/trough parameters are displayed in a blank area between a fetal heart rate curve and a uterine contraction intensity curve, the series connection of the peak/trough related information and the uterine contraction curve information can be realized, and a diagnosis result can be conveniently obtained.
The embodiment of the invention can accurately identify the wave crest/wave trough in the fetal heart rate curve, so that the output fetal heart rate curve can intuitively and accurately display the acceleration and deceleration conditions of the fetal heart rate, the medical staff can conveniently and accurately identify according to the output fetal heart rate curve, the identification accuracy is improved, and the misdiagnosis probability is reduced.
Fig. 7 is a block diagram of a parameter output device for fetal heart rate curves according to an embodiment of the present invention, which can be located in a fetal heart rate monitoring apparatus, for executing the parameter output method for fetal heart rate curves according to the above embodiment. For convenience of explanation, only the portions related to the present embodiment are shown.
Referring to fig. 7, the apparatus includes:
the generating unit 71 generates a fetal heart rate curve according to the original signal collected by the fetal heart monitoring device.
The extracting unit 72 extracts the fetal heart rate curve of a specified time period.
A measuring unit 73 for measuring the peak/trough parameter of the fetal heart rate curve for the specified time period.
And an output unit 74 for outputting the fetal heart rate curve and the measured peak/trough parameters.
Optionally, the extracting unit 72 is specifically configured to:
and extracting a fetal heart rate curve currently displayed on the fetal heart rate monitoring equipment screen.
Optionally, the extracting unit 72 includes:
and the detection subunit receives a selection instruction input by a user and detects a time period selected by the selection instruction in the fetal heart rate curve.
And the curve extraction subunit extracts the fetal heart rate curve of the selected time period from the fetal heart rate curves.
Optionally, the detection subunit is specifically configured to:
receiving a starting point selection instruction input by a user, and detecting a first input position of the starting point selection instruction in the fetal heart rate curve;
receiving an end point selection instruction input by a user, and detecting a second input position of the end point selection instruction in the fetal heart rate curve;
generating two line segments which are perpendicular to each other and intersect on a time axis at the first input position and the second input position respectively;
and determining the time period selected in the fetal heart rate curve according to two generated intersections of the two line segments and a time axis.
Optionally, the measurement unit 73 includes:
and the calculating subunit is used for calculating the fetal heart rate mean value H of the fetal heart rate curve in the specified time period.
And the line segment A generating subunit generates a line segment A which is parallel to a time axis and has the ordinate of H in the specified time period of the fetal heart rate curve.
And the line segment B generating subunit generates a line segment B which is parallel to the time axis and has a vertical distance with the line segment A as a first preset threshold value L in the specified time period of the fetal heart rate curve.
And the intersection point extraction subunit extracts the intersection point of the line segment A and the fetal heart rate curve of the specified time period.
And the judging subunit is used for judging whether any two adjacent intersection points meet the condition that the distance between the two intersection points is greater than a second preset threshold value T and whether the fetal heart rate curve between the two intersection points exceeds the line segment B, and if so, acquiring the fetal heart rate curve between the two adjacent intersection points.
And the first measuring subunit is used for measuring the wave crest/wave trough parameters based on the acquired fetal heart rate curve.
Optionally, the quantum measurement unit is specifically configured to perform at least one of the following three items:
detecting a peak value point M of the acquired fetal heart rate curve, measuring a vertical distance DL from the peak value point M to the line segment A, and outputting the DL as the amplitude of the peak/trough;
detecting the time length DS of the acquired fetal heart rate curve, and outputting the DS as the duration of the wave crest/wave trough;
detecting a starting point N and a peak point M of the acquired fetal heart rate curve, measuring a horizontal distance DR from the starting point N to the peak point M, and determining the DR as the generation time of the wave crest/wave trough.
Optionally, the measurement unit 73 includes:
and the line segment C generating subunit generates a line segment C which is vertical to the time axis in the fetal heart rate curve.
And the second measuring subunit horizontally moves and displays the line segment C at a corresponding position according to the detected movement instruction so as to determine the amplitude of the peak/trough according to the intersection point of the line segment C and the peak/trough of the fetal heart rate curve.
Optionally, the output unit 74 is specifically configured to:
outputting the fetal heart rate curve and the measured peak/trough parameters to a storage device for storage; or,
outputting the fetal heart rate curve and the measured peak/trough parameters to a display device for displaying; or,
and outputting the fetal heart rate curve and the measured wave crest/wave trough parameters to a printing device for printing.
Optionally, the output unit 74 includes:
a time axis generating subunit, configured to generate an independent time axis in a designated area, where the time axis corresponds to a time axis of the fetal heart rate curve one-to-one in time, and the designated area includes a blank area between the fetal heart rate curve and the uterine contraction strength curve;
a labeling subunit, configured to label, according to occurrence time of the peak/valley parameter, the peak/valley parameter at a corresponding position of the independent time axis in the designated area;
and the output subunit is used for simultaneously outputting the fetal heart rate curve and the labeled wave crest/wave trough parameters. The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (12)
1. A method for outputting parameters of a fetal heart rate curve is characterized by comprising the following steps:
generating a fetal heart rate curve according to an original signal acquired by fetal heart monitoring equipment;
extracting the fetal heart rate curve in a specified time period;
measuring a peak/trough parameter of the fetal heart rate curve for the specified time period;
and simultaneously outputting the fetal heart rate curve and the measured peak/trough parameters.
2. The method of claim 1, wherein said measuring a peak/trough parameter of the fetal heart rate curve for the specified time period comprises:
calculating a fetal heart rate mean value H of the fetal heart rate curve of the specified time period;
generating a line segment A which is parallel to a time axis and has a vertical coordinate of H within the specified time period of the fetal heart rate curve;
generating a line segment B which is parallel to a time axis and has a vertical distance with the line segment A as a first preset threshold value L within the specified time period of the fetal heart rate curve;
extracting an intersection point of the line segment A and the fetal heart rate curve of the specified time period;
judging whether any two adjacent intersection points meet the condition that the distance between the two intersection points is larger than a second preset threshold value T and whether the fetal heart rate curve between the two intersection points has a part exceeding the line segment B, if so, acquiring the fetal heart rate curve between the two adjacent intersection points;
measuring the peak/trough parameters based on the acquired fetal heart rate curve.
3. The method of claim 2, wherein said measuring said peak/trough parameters based on said acquired fetal heart rate profile comprises performing at least one of:
detecting a peak value point M of the acquired fetal heart rate curve, measuring a vertical distance DL from the peak value point M to the line segment A, and outputting the DL as the amplitude of the peak/trough;
detecting the time length DS of the acquired fetal heart rate curve, and outputting the DS as the duration of the wave crest/wave trough;
detecting a starting point N and a peak point M of the acquired fetal heart rate curve, measuring a horizontal distance DR from the starting point N to the peak point M, and determining the DR as the generation time of the wave crest/wave trough.
4. The method of claim 1, wherein said measuring a peak/trough parameter of the fetal heart rate curve for the specified time period comprises:
generating a line segment C perpendicular to a time axis in the fetal heart rate curve;
according to the detected movement instruction, the line segment C is horizontally moved and displayed at a corresponding position, so that the amplitude of the peak/trough is determined according to the intersection point of the line segment C and the peak/trough of the fetal heart rate curve.
5. The method of claim 1, wherein said extracting said fetal heart rate curve for a specified period of time comprises:
receiving a selection instruction input by a user, and detecting a time period selected by the selection instruction in the fetal heart rate curve;
extracting the fetal heart rate curve for the selected time period from the fetal heart rate curves.
6. A method according to any one of claims 1 to 5, wherein said simultaneously outputting said fetal heart rate curve and said measured peak/trough parameter comprises:
generating an independent time axis in a designated area, wherein the time axis corresponds to the time axis of the fetal heart rate curve one by one in time, and the designated area comprises a blank area between the fetal heart rate curve and the uterine contraction strength curve;
marking the peak/trough parameters at the corresponding positions of the independent time axis of the designated area according to the occurrence time of the peak/trough parameters;
and simultaneously outputting the fetal heart rate curve and the labeled wave crest/wave trough parameters.
7. A parameter output device for a fetal heart rate curve, comprising:
the generating unit is used for generating a fetal heart rate curve according to the original signals collected by the fetal heart monitoring equipment;
the extraction unit is used for extracting the fetal heart rate curve in a specified time period;
the measuring unit is used for measuring the peak/trough parameters of the fetal heart rate curve in the specified time period;
and the output unit is used for simultaneously outputting the fetal heart rate curve and the measured peak/trough parameters.
8. The apparatus of claim 7, wherein the measurement unit comprises:
the calculating subunit is used for calculating a fetal heart rate mean value H of the fetal heart rate curve of the specified time period;
a segment A generation subunit, configured to generate a segment A parallel to a time axis and having a vertical coordinate of the H within the specified time period of the fetal heart rate curve;
a segment B generating subunit, configured to generate a segment B that is parallel to a time axis and has a vertical distance from the segment A of a first preset threshold L within the specified time period of the fetal heart rate curve;
an intersection point extracting subunit, configured to extract an intersection point between the line segment a and the fetal heart rate curve in the specified time period;
a judging subunit, configured to judge whether any two adjacent intersection points meet a condition that a distance between the two intersection points is greater than a second preset threshold T and whether a fetal heart rate curve between the two intersection points exceeds the line segment B, and if so, obtain the fetal heart rate curve between the two adjacent intersection points;
a first measuring subunit, configured to measure the peak/trough parameter based on the acquired fetal heart rate curve.
9. The apparatus of claim 8, wherein the first measurement subunit is specifically configured to perform at least one of:
detecting a peak value point M of the acquired fetal heart rate curve, measuring a vertical distance DL from the peak value point M to the line segment A, and outputting the DL as the amplitude of the peak/trough;
detecting the time length DS of the acquired fetal heart rate curve, and outputting the DS as the duration of the wave crest/wave trough;
detecting a starting point N and a peak point M of the acquired fetal heart rate curve, measuring a horizontal distance DR from the starting point N to the peak point M, and determining the DR as the generation time of the wave crest/wave trough.
10. The apparatus of claim 7, wherein the measurement unit comprises:
a segment C generating subunit, configured to generate a segment C perpendicular to a time axis in the fetal heart rate curve;
and the second measuring subunit is used for horizontally moving and displaying the line segment C at a corresponding position according to the detected moving instruction so as to determine the amplitude of the peak/trough according to the intersection point of the line segment C and the peak/trough of the fetal heart rate curve.
11. The apparatus of claim 7, wherein the extraction unit comprises:
the detection subunit is used for receiving a selection instruction input by a user and detecting a time period selected by the selection instruction in the fetal heart rate curve;
a curve extraction subunit, configured to extract the fetal heart rate curve of the selected time period from the fetal heart rate curve.
12. The apparatus of any one of claims 7 to 11, wherein the output unit comprises:
a time axis generating subunit, configured to generate an independent time axis in a designated area, where the time axis corresponds to a time axis of the fetal heart rate curve one-to-one in time, and the designated area includes a blank area between the fetal heart rate curve and the uterine contraction strength curve;
a labeling subunit, configured to label, according to occurrence time of the peak/valley parameter, the peak/valley parameter at a corresponding position of the independent time axis in the designated area;
and the output subunit is used for simultaneously outputting the fetal heart rate curve and the labeled wave crest/wave trough parameters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510031500.6A CN104586379B (en) | 2015-01-21 | 2015-01-21 | Method and device for outputting parameters of fetal heart rate curve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510031500.6A CN104586379B (en) | 2015-01-21 | 2015-01-21 | Method and device for outputting parameters of fetal heart rate curve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104586379A true CN104586379A (en) | 2015-05-06 |
| CN104586379B CN104586379B (en) | 2017-05-24 |
Family
ID=53112682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510031500.6A Active CN104586379B (en) | 2015-01-21 | 2015-01-21 | Method and device for outputting parameters of fetal heart rate curve |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104586379B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108742599A (en) * | 2018-03-20 | 2018-11-06 | 深圳大学 | A kind of foetus health early warning system and method |
| CN109567866A (en) * | 2018-10-15 | 2019-04-05 | 广东宝莱特医用科技股份有限公司 | A kind of processing method of Fetal Heart Rate period variation |
| CN109567869A (en) * | 2018-10-15 | 2019-04-05 | 广东宝莱特医用科技股份有限公司 | Accelerate movable method and system on a kind of processing fetal heart rate curve |
| CN113640445A (en) * | 2021-08-11 | 2021-11-12 | 贵州中烟工业有限责任公司 | Characteristic peak identification method based on image processing, computing equipment and storage medium |
| CN113907734A (en) * | 2020-07-10 | 2022-01-11 | 纬创资通股份有限公司 | Signal processing method, apparatus and non-transitory computer readable storage medium |
| CN115177232A (en) * | 2022-07-25 | 2022-10-14 | 深圳市其利天下技术开发有限公司 | Fetal heart rate detection method and device and terminal equipment |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060079783A1 (en) * | 2004-09-30 | 2006-04-13 | Clark David W | Method and system for deriving a fetal heart rate without the use of an electrocardiogram in non-3D imaging applications |
| WO2006079992A1 (en) * | 2005-01-31 | 2006-08-03 | Koninklijke Philips Electronics N.V. | Method and system for deriving a heart rate without the use of an electrocardiogram in non-3d imaging applications |
| CN102048558A (en) * | 2011-01-28 | 2011-05-11 | 深圳市理邦精密仪器股份有限公司 | Fetal heart rate signal processing method and device thereof |
| CN102302363A (en) * | 2011-06-29 | 2012-01-04 | 深圳市理邦精密仪器股份有限公司 | Device and method for automatically identifying fetal heart rate baseline |
| CN102319063A (en) * | 2011-07-26 | 2012-01-18 | 深圳市理邦精密仪器股份有限公司 | Device and method for improving acceleration identification accuracy of fetal heart rate data |
| WO2013053290A1 (en) * | 2011-10-13 | 2013-04-18 | 深圳市理邦精密仪器股份有限公司 | Device and method for improving identification accuracy of fetal heart rate deceleration |
| CN103784130A (en) * | 2014-01-24 | 2014-05-14 | 深圳市理邦精密仪器股份有限公司 | Method and system for improving fetal heart rate curve efficiency |
-
2015
- 2015-01-21 CN CN201510031500.6A patent/CN104586379B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060079783A1 (en) * | 2004-09-30 | 2006-04-13 | Clark David W | Method and system for deriving a fetal heart rate without the use of an electrocardiogram in non-3D imaging applications |
| WO2006079992A1 (en) * | 2005-01-31 | 2006-08-03 | Koninklijke Philips Electronics N.V. | Method and system for deriving a heart rate without the use of an electrocardiogram in non-3d imaging applications |
| CN102048558A (en) * | 2011-01-28 | 2011-05-11 | 深圳市理邦精密仪器股份有限公司 | Fetal heart rate signal processing method and device thereof |
| CN102302363A (en) * | 2011-06-29 | 2012-01-04 | 深圳市理邦精密仪器股份有限公司 | Device and method for automatically identifying fetal heart rate baseline |
| CN102319063A (en) * | 2011-07-26 | 2012-01-18 | 深圳市理邦精密仪器股份有限公司 | Device and method for improving acceleration identification accuracy of fetal heart rate data |
| WO2013053290A1 (en) * | 2011-10-13 | 2013-04-18 | 深圳市理邦精密仪器股份有限公司 | Device and method for improving identification accuracy of fetal heart rate deceleration |
| CN103784130A (en) * | 2014-01-24 | 2014-05-14 | 深圳市理邦精密仪器股份有限公司 | Method and system for improving fetal heart rate curve efficiency |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108742599A (en) * | 2018-03-20 | 2018-11-06 | 深圳大学 | A kind of foetus health early warning system and method |
| CN109567866A (en) * | 2018-10-15 | 2019-04-05 | 广东宝莱特医用科技股份有限公司 | A kind of processing method of Fetal Heart Rate period variation |
| CN109567869A (en) * | 2018-10-15 | 2019-04-05 | 广东宝莱特医用科技股份有限公司 | Accelerate movable method and system on a kind of processing fetal heart rate curve |
| CN109567869B (en) * | 2018-10-15 | 2022-03-11 | 广东宝莱特医用科技股份有限公司 | Method and system for processing accelerated activities on fetal heart rate curve |
| CN113907734A (en) * | 2020-07-10 | 2022-01-11 | 纬创资通股份有限公司 | Signal processing method, apparatus and non-transitory computer readable storage medium |
| CN113907734B (en) * | 2020-07-10 | 2024-10-11 | 纬创资通股份有限公司 | Signal processing method, device and non-transitory computer readable storage medium |
| CN113640445A (en) * | 2021-08-11 | 2021-11-12 | 贵州中烟工业有限责任公司 | Characteristic peak identification method based on image processing, computing equipment and storage medium |
| CN113640445B (en) * | 2021-08-11 | 2024-06-11 | 贵州中烟工业有限责任公司 | Characteristic peak identification method based on image processing, computing device and storage medium |
| CN115177232A (en) * | 2022-07-25 | 2022-10-14 | 深圳市其利天下技术开发有限公司 | Fetal heart rate detection method and device and terminal equipment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104586379B (en) | 2017-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104586379B (en) | Method and device for outputting parameters of fetal heart rate curve | |
| US9801609B2 (en) | Device and method for enhancing accuracy of recognizing fetus heart rate acceleration data | |
| CN103735259B (en) | Electrocardio signal quality determination indication method and system | |
| Romano et al. | Software for computerised analysis of cardiotocographic traces | |
| EP2224346A2 (en) | ECG signal analysis tool | |
| KR20160016460A (en) | Apparatus and method for visualization of region of interest | |
| CN102512150B (en) | Alarm method and alarm device for fetal monitoring | |
| CN113040823B (en) | Ultrasonic imaging equipment and ultrasonic image analysis method | |
| CN104586378A (en) | Method and device for outputting fetal heart rate curve | |
| CN106963361B (en) | Detection method, detection device and the electrocardio equipment of limb leads misconnection | |
| CN103190913B (en) | Fetal movement recognition method, fetal movement recognition equipment and fetal monitor | |
| CN105147269A (en) | Noninvasive continuous blood pressure measuring method | |
| Romagnoli et al. | Digital cardiotocography: What is the optimal sampling frequency? | |
| CN104055506B (en) | A kind of fetal monitoring data processing method and device | |
| CN108618777A (en) | The processing method and processing device of ST segment signals, cardioelectric monitor equipment in electrocardiosignal | |
| CN109567869B (en) | Method and system for processing accelerated activities on fetal heart rate curve | |
| CN106805960A (en) | Portable fetus patient monitor | |
| WO2012140966A1 (en) | Biophotonic measurement device, biophotonic measurement device operating method, and biophotonic measurement data analysis and display method | |
| JPWO2019004394A1 (en) | Monitoring device for mother and fetus, display device for monitoring device | |
| CN110236594B (en) | A fetal movement signal identification and marking method, system, medium and equipment | |
| CN201147302Y (en) | Synthetic physical ability testing device | |
| CN109589137A (en) | Method, apparatus, terminal and the computer readable storage medium of movement of the foetus identification | |
| KR20130017642A (en) | Display method for bio-signal | |
| CN112716525B (en) | Fetal heart rate processing method and device and readable storage medium | |
| CN102715897B (en) | Method for determining average heart rates of fetuses on basis of fetal electrocardio spectrograms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |