CN104557593A - Preparation process of paracetamol - Google Patents
Preparation process of paracetamol Download PDFInfo
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- CN104557593A CN104557593A CN201410760834.2A CN201410760834A CN104557593A CN 104557593 A CN104557593 A CN 104557593A CN 201410760834 A CN201410760834 A CN 201410760834A CN 104557593 A CN104557593 A CN 104557593A
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- paracetamol
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Abstract
The invention discloses a preparation process of paracetamol. The preparation process comprises the following steps: 1) adding 1 part by weight of deionized water, 0.1 part by weight of metal zinc, 18 parts by weight of p-aminophenol and 34 parts by weight of acetic acid to a reactor, increasing the temperature to 45 DEG C, and stirring evenly to obtain a reaction liquid; 2) inputting the reaction liquid into a dehydration membrane device for reacting for 8 hour under the pressure of -0.1MPa on the back-pressure side, and extracting moisture; 3) cooling the temperature to 15 DEG C, crystalizing for 8 hours, and centrifugally filtering to obtain paracetamol crystals; and 4) drying in vacuum at 60 DEG C for 20 hours at the vacuum degree of -0.1MPa, thereby obtaining the finished product paracetamol. The preparation process of the paracetamol is capable of avoiding the generation of waste acids, improving the product quality and reducing the energy consumption of the product.
Description
Technical field
The present invention relates to the preparation technology of Paracetamol.
Background technology
At present, the production process of Paracetamol has spent acid and produces, and energy consumption is higher, and quality product haves much room for improvement.
Summary of the invention
The object of the present invention is to provide a kind of preparation technology of Paracetamol, it can avoid the generation of spent acid, improves quality product, reduces product energy consumption.
For achieving the above object, technical scheme of the present invention designs a kind of preparation technology of Paracetamol, comprises the steps:
1) 1 parts by weight of deionized water, 0.1 part by weight of metal zinc, 18 weight part p-aminophenol, 34 parts by weight acetic acid are added reactor, be warming up to 45 DEG C, stir, obtain reaction solution;
2) reaction solution is inputted dehydrated film device, react 8 hours, back pressure wall pressure is-0.1MPa, extracts moisture out;
3) be cooled to 15 DEG C, crystallization 8 hours, centrifuging, obtains Paracetamol crystallization;
4) in 60 DEG C of vacuum-dryings 20 hours, vacuum tightness is-0.1Mpa, obtains Paracetamol finished product.
Advantage of the present invention and beneficial effect are: the preparation technology providing a kind of Paracetamol, and it can avoid the generation of spent acid, improves quality product, reduce product energy consumption.
Embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is further described.Following examples only for technical scheme of the present invention is clearly described, and can not limit the scope of the invention with this.
The technical scheme that the present invention specifically implements is:
A preparation technology for Paracetamol, comprises the steps:
1) 1 parts by weight of deionized water, 0.1 part by weight of metal zinc, 18 weight part p-aminophenol, 34 parts by weight acetic acid are added reactor, be warming up to 45 DEG C, stir, obtain reaction solution;
2) reaction solution is inputted dehydrated film device, react 8 hours, back pressure wall pressure is-0.1MPa, extracts moisture out;
3) be cooled to 15 DEG C, crystallization 8 hours, centrifuging, obtains Paracetamol crystallization;
4) in 60 DEG C of vacuum-dryings 20 hours, vacuum tightness is-0.1Mpa, obtains Paracetamol finished product.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (1)
1. the preparation technology of Paracetamol, is characterized in that, comprises the steps:
1) 1 parts by weight of deionized water, 0.1 part by weight of metal zinc, 18 weight part p-aminophenol, 34 parts by weight acetic acid are added reactor, be warming up to 45 DEG C, stir, obtain reaction solution;
2) reaction solution is inputted dehydrated film device, react 8 hours, back pressure wall pressure is-0.1MPa, extracts moisture out;
3) be cooled to 15 DEG C, crystallization 8 hours, centrifuging, obtains Paracetamol crystallization;
4) in 60 DEG C of vacuum-dryings 20 hours, vacuum tightness is-0.1Mpa, obtains Paracetamol finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410760834.2A CN104557593A (en) | 2014-12-13 | 2014-12-13 | Preparation process of paracetamol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410760834.2A CN104557593A (en) | 2014-12-13 | 2014-12-13 | Preparation process of paracetamol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104557593A true CN104557593A (en) | 2015-04-29 |
Family
ID=53074773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410760834.2A Pending CN104557593A (en) | 2014-12-13 | 2014-12-13 | Preparation process of paracetamol |
Country Status (1)
| Country | Link |
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| CN (1) | CN104557593A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105152956A (en) * | 2015-08-05 | 2015-12-16 | 安丘市鲁安药业有限责任公司 | Process and device for acylation reaction of acetaminophen |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010072277A1 (en) * | 2008-12-22 | 2010-07-01 | Klosterfrau Berlin Gmbh | Local anesthetic for relieving breast pain |
| CN101250131B (en) * | 2008-03-15 | 2011-02-16 | 西北师范大学 | Preparation technique of p-acetyl aminophenol |
| CN103508916A (en) * | 2013-10-25 | 2014-01-15 | 山东新华制药股份有限公司 | Preparation technology for paracetamol |
-
2014
- 2014-12-13 CN CN201410760834.2A patent/CN104557593A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101250131B (en) * | 2008-03-15 | 2011-02-16 | 西北师范大学 | Preparation technique of p-acetyl aminophenol |
| WO2010072277A1 (en) * | 2008-12-22 | 2010-07-01 | Klosterfrau Berlin Gmbh | Local anesthetic for relieving breast pain |
| CN103508916A (en) * | 2013-10-25 | 2014-01-15 | 山东新华制药股份有限公司 | Preparation technology for paracetamol |
Non-Patent Citations (2)
| Title |
|---|
| 吴晓云等: "对乙酰氨基苯酚生产技术", 《精细石油化工进展》 * |
| 李勤耕等: "扑热息痛工艺改进", 《华西药学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105152956A (en) * | 2015-08-05 | 2015-12-16 | 安丘市鲁安药业有限责任公司 | Process and device for acylation reaction of acetaminophen |
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Application publication date: 20150429 |