CN104548972B - A kind of preparation method of pharmaceutical bilobalide molecular engram polysulfones hybridized film - Google Patents
A kind of preparation method of pharmaceutical bilobalide molecular engram polysulfones hybridized film Download PDFInfo
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- CN104548972B CN104548972B CN201410617850.6A CN201410617850A CN104548972B CN 104548972 B CN104548972 B CN 104548972B CN 201410617850 A CN201410617850 A CN 201410617850A CN 104548972 B CN104548972 B CN 104548972B
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- bilobalide
- molecular engram
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- polysulfones
- benzoyl peroxide
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- MOLPUWBMSBJXER-NRSGSQFTSA-N Bilobalide A Chemical compound O([C@H]1OC2=O)C(=O)[C@@H](O)[C@@]11[C@@](C(C)(C)C)(O)C[C@H]3[C@@]21CC(=O)O3 MOLPUWBMSBJXER-NRSGSQFTSA-N 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 229920002492 poly(sulfones) Polymers 0.000 title claims abstract description 16
- 239000012528 membrane Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000011248 coating agent Substances 0.000 claims abstract description 18
- 238000000576 coating method Methods 0.000 claims abstract description 18
- 229920000642 polymer Polymers 0.000 claims abstract description 17
- 229920003288 polysulfone Polymers 0.000 claims abstract description 17
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 16
- 239000000178 monomer Substances 0.000 claims abstract description 15
- 239000004342 Benzoyl peroxide Substances 0.000 claims abstract description 13
- OMPJBNCRMGITSC-UHFFFAOYSA-N Incidol Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000019400 benzoyl peroxide Nutrition 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000003960 organic solvent Substances 0.000 claims abstract description 12
- 238000004090 dissolution Methods 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000011187 glycerol Nutrition 0.000 claims abstract description 6
- 238000007654 immersion Methods 0.000 claims abstract description 6
- 238000007710 freezing Methods 0.000 claims abstract description 3
- 239000003999 initiator Substances 0.000 claims abstract 2
- MOLPUWBMSBJXER-YDGSQGCISA-N Bilobalide Chemical compound O([C@H]1OC2=O)C(=O)[C@H](O)[C@@]11[C@@](C(C)(C)C)(O)C[C@H]3[C@@]21CC(=O)O3 MOLPUWBMSBJXER-YDGSQGCISA-N 0.000 claims description 26
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 8
- -1 tetramethylene dimethyl propylene Olefin Chemical class 0.000 claims description 8
- HRPVXLWXLXDGHG-UHFFFAOYSA-N acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 5
- FXHOOIRPVKKKFG-UHFFFAOYSA-N DMA Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 3
- BHBPJIPGXGQMTE-UHFFFAOYSA-N ethane-1,2-diol;2-methylprop-2-enoic acid Chemical group OCCO.CC(=C)C(O)=O.CC(=C)C(O)=O BHBPJIPGXGQMTE-UHFFFAOYSA-N 0.000 claims description 3
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 150000002596 lactones Chemical class 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 5
- 238000000926 separation method Methods 0.000 description 14
- 238000002425 crystallisation Methods 0.000 description 9
- 230000005712 crystallization Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 7
- 239000012071 phase Substances 0.000 description 7
- 210000004940 Nucleus Anatomy 0.000 description 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000005755 formation reaction Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 229920000344 Molecularly imprinted polymer Polymers 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N Theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000005039 chemical industry Methods 0.000 description 2
- 238000001311 chemical methods and process Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000004134 energy conservation Methods 0.000 description 2
- 229930003944 flavones Natural products 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N n-methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 240000002883 Ginkgo biloba Species 0.000 description 1
- 210000000582 Semen Anatomy 0.000 description 1
- 229960000278 Theophylline Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 102000004965 antibodies Human genes 0.000 description 1
- 108090001123 antibodies Proteins 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N flavone Chemical compound O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 235000000381 ginkgo Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003278 mimic Effects 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 239000005445 natural product Substances 0.000 description 1
- 229930014626 natural products Natural products 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 238000010951 particle size reduction Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003883 substance clean up Methods 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000003612 virological Effects 0.000 description 1
Abstract
The invention discloses the preparation method of a kind of pharmaceutical bilobalide molecular engram polysulfones hybridized film, comprise the steps: (1), the polysulfone membrane prepared is contacted with the solution containing benzoyl peroxide, then dry, it is thus achieved that film surface-coated has the polysulfone membrane of initiator；(2) molecular engram coating liquid, is prepared: by bilobalide dissolution of crystals in organic solvent；It is subsequently adding polymer monomer, and cross-linking agent；(3), by step 2) the molecular engram coating liquid coating for preparing contains on the surface of benzoyl peroxide to polysulfone membrane, temperature 40 60 DEG C is reacted 30 60 minutes, it is then added to freezing film in the deionized water of 25 DEG C, by the glycerine water solution immersion treatment 10～20h that mass concentration is 20～50%, last again with methanol is soaked 24 hours, thoroughly remove bilobalide crystal, then clean with deionized water, obtain described bilobalide molecular engram polysulfones hybridized film.
Description
Technical field
The present invention relates to the preparation method of a kind of bilobalide molecular engram polysulfones hybridized film.
Background technology
Lactone compound is widely present in plant kingdom, is one of important active ingredient of natural product, anti-
The aspect such as viral, anticancer has significant effect, is widely used to clinic.Effective ingredient ratio in plant
More complicated, at present the isolation and purification method that flavone compound is main there are macroreticular resin absorbing method, supercritical
Fluid extraction etc., but these technology exist and the compound that structure is similar can not be carried out clean cut separation and set
Standby investment is bigger waits deficiency.Membrane separation technique is the isolation technics that twentieth century is emerging, have energy-conservation, efficient,
Can the feature such as seriality operation, be applied in the separation of lactone compound, purification research achieve preferably
Progress.But the selectivity of membrance separation is carried out by molecular cut off at present, and lactone compound kind
Many, molecular weight is close, and structure is similar, it is difficult to realize the high Selective Separation to single flavone compound
Purification.
Molecular imprinting (Molecular Imprinting Technique) is to utilize molecularly imprinted polymer
" memory " function with microsphere stereochemical structure and shape carries out a kind of technology of specific molecular identification,
Therefore there is precordainment and identity, delivered relevant on " Nature " from Mosbach in 1993 etc.
Can separate theophylline molecularly imprinted polymer report since, developed rapidly, become chemistry, biology,
The crossing domain of the subject such as macromolecular material, medical science, at chromatographic stationary phases, Solid-Phase Extraction, membrance separation, exempts from
The aspects such as epidemic disease analysis, antibodies mimic, imitative biosensor, catalyst and synzyme show good application
Prospect.
Molecular engram film is a kind of new technique grown up on the basis of molecular imprinting, with dividing
Sub-trace and the two-fold advantage of membrane technology.The basic ideas of molecular engram film preparation are to introduce in polymerisation medium
Microsphere, removes microsphere after film forming, forms the network structure adapted with template molecule in film,
And it is inlaid with the functional group interacted with template molecule, when separating the mixture containing template molecule,
Template molecule can be gone out and efficiently separates out by Selective recognition.The preparation method of molecular engram film mainly has former
Position polymerization, phase inversion, surface modification, electrochemical process etc..Situ aggregation method and phase inversion are molecules
The preparation method of trace integral membrane.Situ aggregation method is that the polyreaction by free radical prepares molecular engram film,
Gained membrane porosity is low, and flux is little.Phase inversion is without radical polymerization, and preparation process is simple, is current
One of preparation method of more research.The trace point position that it is critical only that on control film that phase inversion prepares film is same
Time create the film with good pore morphology, improve the transmission characteristic of film while optimizing molecular recognition performance.
The molecular engram film prepared by phase inversion has good separating property in aqueous phase.But, although
Phase inversion is very suitable for the preparation of molecular engram film, but owing to the optimum condition of imprinted sites formation may
It not the formation condition of optimized membrane pore structure, so molecular engram film preparation process is subject to certain restrictions.
It addition, the imprinted sites of molecular engram film is randomly dispersed in inside and the surface of polymer phase, seriality duct
Formation there be difficulties involved when the separating property of film is all had a certain impact, make the separating property of film reduce,
Property high Selective Separation effectively continuous to target molecule there be difficulties involved when.
Membrane science has become an independent science.The most most widely used is polymeric membrane for separation, belongs to high score
The one of subfunction film.Separate film and effectively promote development and the raising of isolation technics.Its work of separation now
Can from initial microporous filter separation solidliquid mixture develop into molecular level mixture separation, saltout, electricity
The separation solving matter separates with transmission, gas and enrichment etc..Separate at present film biological engineering, desalinization,
In medicament slow release, controlled release and chemical process, the field such as the separation of mixture and steam has reached practical.
Separate film and there is the features such as energy-conservation, efficient, environmentally friendly.
In vegetable Chinese herbal medicine, extracting and developing active component is one of content of the modernization of Chinese medicine.The side extracted
Fado is traditional solvent extraction, or organic solvent, or water, or mixed solvent, or super faces
Boundary fluid CO2 etc..But no matter using which kind of solvent, that extracts isolated is crude extract, and its purification is many
Use recrystallization.
Solution crystallization is the traditional method of material purifies and separates, is also an important chemical process.Solute from
Solution crystallizes out and to experience two steps: nucleus generates and crystal growth.It is in supersaturation that nucleus generates
Solution generates a number of nucleus；And on the basis of nucleus, grow into crystal, then it is crystal growth.
The factor affecting whole crystallization process is a lot, such as the degree of supersaturation of solution, the existence of impurity, the speed of stirring
And various physical fields etc..In industrial crystallization, pursue high crystal growth rate to improve equipment
Production capacity, but actually rate of crystalline growth generally limiting by problems such as required specific product quality
System, does not allow to use raising degree of supersaturation to improve growth rate, will seek under suitable degree of supersaturation
Additive method is pushed to crystal growing process.The impact on crystallization kinetics of the such as sound field, Zhang Ximei etc. was once
Have studied the sound field impact on solution nucleation, stability of solution and crystal growth system, and further investigated its
Influencing Mechanism (Zhang Ximei, Qiu Taiqiu, Li Yuehua. the research [J] that solution crystallization kinetics is affected by sound field.
Chemistry circular, 1997,1:44～46)；The magnetic field impact on crystallization, bavin really respects to wait the most also to be had together
Sample finds, and utilizes the action of a magnetic field, controls crystal growth, make crystal particle size reduction (Chai Chengjing. magnetization skill
Art application in chemical separating field. chemical industry and engineering, 1999, (16) 4:245～249)；Its
His outfield facilitation to crystallizing also is effective.
Along with industrial expansion, efficient Crystallization Separation technology are at oil, chemical industry, biotechnology and ring
The application in the fields such as border protection is more and more extensive, and the research of industrial crystallization technology and correlation theory is also pushed to newly
Stage, domestic and international novel crystallization technology achieves greater advance, and wherein crystalization in supercritical fluid is a kind of new
The method for crystallising of type.
Summary of the invention
It is an object of the invention to propose the preparation method of a kind of bilobalide molecular engram polysulfones hybridized film.
For reaching this purpose, the present invention by the following technical solutions:
The preparation method of a kind of bilobalide molecular engram polysulfones hybridized film, comprises the steps: (1), will make
The polysulfone membrane got ready contacts with the solution containing benzoyl peroxide, then dries, it is thus achieved that film surface-coated has draws
Send out the polysulfone membrane of agent；The mass percentage content of benzoyl peroxide is 0.05～1%；
(2) molecular engram coating liquid, is prepared: by bilobalide dissolution of crystals in organic solvent；Then add
Enter polymer monomer, and cross-linking agent；Described bilobalide with the mass ratio of polymer monomer and cross-linking agent is:
1:1-3:2-8；Described organic solvent is N,N-dimethylacetamide or dimethylformamide or N-methyl
-2-Pyrrolidone, solution temperature is 45～65 DEG C, carries out ultrasonic disperse simultaneously；Described polymer monomer
For acrylamide；Described cross-linking agent is selected from ethylene glycol dimethacrylate or tetramethylene dimethyl allene
Acid esters；
(3), by step 2) the molecular engram coating liquid coating for preparing contains benzoyl peroxidating to polysulfone membrane
On the surface of thing, react 30-60 minute in temperature 40-60 DEG C, be then added in the deionized water of 25 DEG C
Freezing film, by the glycerine water solution immersion treatment 10～20h that mass concentration is 20～50%, uses the most again
Methanol soaks 24 hours, thoroughly removes bilobalide crystal, then cleans with deionized water, obtains described Semen Ginkgo
Lactone molecule trace polysulfones hybridized film.
Detailed description of the invention
Embodiment 1
The preparation method of a kind of bilobalide molecular engram polysulfones hybridized film, comprises the steps: (1), will make
The polysulfone membrane got ready contacts with the solution containing benzoyl peroxide, then dries, it is thus achieved that film surface-coated has draws
Send out the polysulfone membrane of agent；The mass percentage content of benzoyl peroxide is 1%；
(2) molecular engram coating liquid, is prepared: by bilobalide dissolution of crystals in organic solvent；Then add
Enter polymer monomer, and cross-linking agent；Described bilobalide with the mass ratio of polymer monomer and cross-linking agent is:
1:1:2；Described organic solvent is N,N-dimethylacetamide or dimethylformamide, and solution temperature is
45 DEG C, carry out ultrasonic disperse simultaneously；Described polymer monomer is acrylamide；Described cross-linking agent is selected from
Ethylene glycol dimethacrylate
(3), by step 2) the molecular engram coating liquid coating for preparing contains benzoyl peroxidating to polysulfone membrane
On the surface of thing, react 30 minutes in temperature 40 DEG C, be then added in the deionized water of 25 DEG C be frozen into
Film, by glycerine water solution immersion treatment 10h that mass concentration is 20%, last again with methanol is soaked 24 hours,
Thoroughly remove bilobalide crystal, then clean with deionized water, obtain described bilobalide molecular engram polysulfones
Hybridized film.
Embodiment 2
The preparation method of a kind of bilobalide molecular engram polysulfones hybridized film, comprises the steps: (1), will make
The polysulfone membrane got ready contacts with the solution containing benzoyl peroxide, then dries, it is thus achieved that film surface-coated has draws
Send out the polysulfone membrane of agent；The mass percentage content of benzoyl peroxide is 0.05%；
(2) molecular engram coating liquid, is prepared: by bilobalide dissolution of crystals in organic solvent；Then add
Enter polymer monomer, and cross-linking agent；Described bilobalide with the mass ratio of polymer monomer and cross-linking agent is:
1:3:8；Described organic solvent is dimethylformamide or METHYLPYRROLIDONE, and solution temperature is
65 DEG C, carry out ultrasonic disperse simultaneously；Described polymer monomer is acrylamide；Described cross-linking agent is selected from
Tetramethylene dimethylacrylate；
(3), by step 2) the molecular engram coating liquid coating for preparing contains benzoyl peroxidating to polysulfone membrane
On the surface of thing, react 60 minutes in temperature 60 C, be then added in the deionized water of 25 DEG C be frozen into
Film, by glycerine water solution immersion treatment 20h that mass concentration is 50%, last again with methanol is soaked 24 hours,
Thoroughly remove bilobalide crystal, then clean with deionized water, obtain described bilobalide molecular engram polysulfones
Hybridized film.
Embodiment 3
The preparation method of a kind of bilobalide molecular engram polysulfones hybridized film, comprises the steps: (1), will make
The polysulfone membrane got ready contacts with the solution containing benzoyl peroxide, then dries, it is thus achieved that film surface-coated has draws
Send out the polysulfone membrane of agent；The mass percentage content of benzoyl peroxide is 0.5%；
(2) molecular engram coating liquid, is prepared: by bilobalide dissolution of crystals in organic solvent；Then add
Enter polymer monomer, and cross-linking agent；Described bilobalide with the mass ratio of polymer monomer and cross-linking agent is:
1:2:6；Described organic solvent is N,N-dimethylacetamide, and solution temperature is 55 DEG C, carries out simultaneously
Ultrasonic disperse；Described polymer monomer is acrylamide；Described cross-linking agent is selected from tetramethylene dimethyl
Acrylate；
(3), by step 2) the molecular engram coating liquid coating for preparing contains benzoyl peroxidating to polysulfone membrane
On the surface of thing, react 50 minutes in temperature 50 C, be then added in the deionized water of 25 DEG C be frozen into
Film, by glycerine water solution immersion treatment 115h that mass concentration is 30%, it is little that last again with methanol soaks 24
Time, thoroughly remove bilobalide crystal, then clean with deionized water, obtain described bilobalide molecular engram
Polysulfones hybridized film.
Claims (1)
1. the preparation method of a pharmaceutical bilobalide molecular engram polysulfones hybridized film, it is characterised in that
Comprise the steps: (1), the polysulfone membrane prepared contacted with the solution containing benzoyl peroxide, then
Dry, it is thus achieved that film surface-coated has the polysulfone membrane of initiator；The mass percentage content of benzoyl peroxide
It is 0.05～1%；
(2) molecular engram coating liquid, is prepared: by bilobalide dissolution of crystals in organic solvent；Then add
Enter polymer monomer and cross-linking agent；Described bilobalide with the mass ratio of polymer monomer and cross-linking agent is
1:1-3:2-8；Described organic solvent is N,N-dimethylacetamide or dimethylformamide or N-first
Base-2-Pyrrolidone, solution temperature is 45～65 DEG C, carries out ultrasonic disperse simultaneously；Described polymer list
Body is acrylamide；Described cross-linking agent is selected from ethylene glycol dimethacrylate or tetramethylene dimethyl propylene
Olefin(e) acid ester；
(3), by step 2) poly-to containing benzoyl peroxide of the molecular engram coating liquid coating for preparing
On sulfone film surface, react 30-60 minute in temperature 40-60 DEG C, be then added in the deionized water of 25 DEG C
Freezing film, by the glycerine water solution immersion treatment 10～20h that mass concentration is 20～50%, uses the most again
Methanol soaks 24 hours, thoroughly removes bilobalide crystal, then cleans with deionized water, obtains described silver
Fructus Pruni lactone molecule trace polysulfones hybridized film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410617850.6A CN104548972B (en) | 2014-11-05 | A kind of preparation method of pharmaceutical bilobalide molecular engram polysulfones hybridized film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410617850.6A CN104548972B (en) | 2014-11-05 | A kind of preparation method of pharmaceutical bilobalide molecular engram polysulfones hybridized film |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104548972A CN104548972A (en) | 2015-04-29 |
| CN104548972B true CN104548972B (en) | 2017-01-04 |
Family
ID=
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0931583A1 (en) * | 1998-01-26 | 1999-07-28 | Kurita Water Industries Ltd. | Spiral wound type membrane module |
| CN1772356A (en) * | 2005-11-02 | 2006-05-17 | 华东理工大学 | Composite fiber membrane with chiral molecular imprint and its prepn and application |
| CN101406813A (en) * | 2008-11-20 | 2009-04-15 | 天津大学 | Method for producing polysulfones hybrid membrane with separated pore passages formed by LUM particles |
| CN102512993A (en) * | 2011-11-18 | 2012-06-27 | 天津工业大学 | Boron-removed polysulphone modified affinitive membrane as well as preparation method and application |
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0931583A1 (en) * | 1998-01-26 | 1999-07-28 | Kurita Water Industries Ltd. | Spiral wound type membrane module |
| CN1772356A (en) * | 2005-11-02 | 2006-05-17 | 华东理工大学 | Composite fiber membrane with chiral molecular imprint and its prepn and application |
| CN101406813A (en) * | 2008-11-20 | 2009-04-15 | 天津大学 | Method for producing polysulfones hybrid membrane with separated pore passages formed by LUM particles |
| CN102512993A (en) * | 2011-11-18 | 2012-06-27 | 天津工业大学 | Boron-removed polysulphone modified affinitive membrane as well as preparation method and application |
Non-Patent Citations (1)
| Title |
|---|
| 中药制剂分离与纯化新技术应用进展;陈秦娥等;《江西中医药》;20120630;第43卷(第354期);第72-76页 * |
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