CN104548381A - Soft-foundation conformal uniform light irradiation photodynamics therapy device - Google Patents

Soft-foundation conformal uniform light irradiation photodynamics therapy device Download PDF

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Publication number
CN104548381A
CN104548381A CN201510055034.5A CN201510055034A CN104548381A CN 104548381 A CN104548381 A CN 104548381A CN 201510055034 A CN201510055034 A CN 201510055034A CN 104548381 A CN104548381 A CN 104548381A
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China
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therapy
soft
light
uniform light
foundation
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CN201510055034.5A
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Chinese (zh)
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何林欢
胡晓明
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北京理工大学
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Priority to CN201510055034.5A priority Critical patent/CN104548381A/en
Publication of CN104548381A publication Critical patent/CN104548381A/en

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Abstract

The invention relates to a soft-foundation conformal uniform light irradiation photodynamics therapy device. Area of a treated patient is acquired by performing three-dimensional reconstruction on a body surface focus area, a contact face is made by a high-transparency soft-foundation material such as flexible silica gel, and therapy light is guided in by optical fibers and uniformly distributed by a light uniformizing plate and transparent liquid. The soft-foundation conformal uniform light irradiation photodynamics therapy device can be accurately fitted with the focus area, number of the optical fibers, power of the therapy light and wavelength of the therapy light can be changed according to therapy needs, different requirements on body surface photodynamics therapy are met, and therapy effect is improved.

Description

一种软基适形均匀光照射光动力治疗装置 A soft conformable yl uniform light irradiation apparatus for photodynamic therapy

技术领域 FIELD

[0001] 本发明涉及一种软基、适形均匀光照射光动力治疗装置,适用于体表皮肤疾病接触照射的光动力治疗,例如鲜红斑痣,座疮等。 [0001] The present invention relates to a group of soft, conformable uniform light irradiation for photodynamic therapy apparatus for photodynamic therapy of skin diseases contacting surface irradiation, e.g. PWS, acne and the like.

技术背景 technical background

[0002] 光动力疗法(TOT)是利用光敏剂与特定波长光进行辐射产生光动力反应,即一系列光化学反应,其反应生成物(激发态单线态氧分子)具有极强的氧化性,能杀死周围病变的细胞,进而达到治疗目的的一种新技术,相比传统治疗方案,PDT具有副作用小、毒性低、选择适用性好、微创等优点。 [0002] Photodynamic therapy (the TOT) is the photosensitizer light radiation with a particular wavelength photodynamic reactions, i.e., a series of photochemical reaction, reaction product (excited singlet oxygen molecules) has strong oxidation resistance, can kill the cells around the lesion, so as to achieve a new technology for therapeutic purposes, as compared to the conventional treatment program, with the PDT side effects, low toxicity, good applicability selected, minimally invasive advantages.

[0003] 光动力治疗有三个关键影响因素:光敏剂,光源和细胞中的氧分子。 [0003] Photodynamic therapy has three key factors: a photosensitizer, light and oxygen molecules in the cells. 目前各种光动力治疗仪器的光源大多固定在硬基板上,不能根据治疗要求进行相应的弯曲调整。 Most of the current light source for various photodynamic therapy apparatus is fixed to the solid substrate, can not be adjusted according to the treatment appropriate bending requirements. 因而导致不同部位或者同一部位不同曲率不同角度病灶区域接收到的光功率密度不同,如面部,颈部。 Resulting in different parts of different curvatures at different angles or areas of the same lesion site different received power density, such as the face, neck. 治疗光源不能同时垂直均匀照射不同曲率方向不同角度的病灶区域皮肤,病灶区内皮肤接收到差异较大的光功率密度,极大程度影响治疗效果。 Treatment uniform illumination light can not perpendicular direction of curvature at different angles in different regions of the skin lesions, skin lesions zone large difference received power density, greatly affect the treatment. 此外,光动力治疗过程中由于治疗光带有较高的能量,会使治疗部位发热,让患者稍感不适,本装置采用高透明液体做光传播介质不仅可提高治疗光照的均匀性,也能降低病灶区域温度,减轻患者在治疗过程中的痛苦。 Further, since the process of photodynamic therapy with high energy light treatment, the treatment site causes fever, the patient some discomfort, the present apparatus with high light propagation medium transparent liquid do not only improve the therapeutic illumination uniformity, but also reduce the temperature of the lesion area, alleviate the suffering of patients in the treatment process.

发明内容 SUMMARY

[0004] 本发明是一种体表皮肤疾病的光动力治疗装置,通过所述装置组合可以实现治疗光在病灶区域各个位置方向的均匀照射。 [0004] The present invention is an apparatus for photodynamic therapy of surface skin diseases, uniform illumination light can be achieved in various directions focus position of the region treated by a combination of means.

[0005] 本发明的技术方案为:运用三维重建系统对病灶区域进行三维重建确定病灶区域的面积和形状,经三维展开后得到相应大小的平面,将高透明柔性材料结合匀光板和内表面镀反光膜的硬质板组成前后两个封闭空腔,并在前空腔内充满高透明液体,治疗光源通过光纤导入,光纤末端插入治疗装置后空腔内距匀光板合适距离,根据病情严重程度,后空腔盖可以制造成不同孔数量的板,以插入不同数量的光纤,导入不同光功率密度的治疗光进行治疗。 [0005] aspect of the present invention are: the use of three-dimensional reconstruction system lesion area three-dimensional reconstruction to determine the area and shape of the lesion area, the expanded three-dimensionally to obtain a plane corresponding size, high transparent flexible material binding uniform light plate and the inner surface of the plating hard plate form two reflective film before and after the cavity is closed, and filled with a liquid highly transparent front cavity, the treatment light through the optical fiber introduction, the cavity insert from the rear end of the fiber plate uniform light therapy device suitable distance, according to the severity of the disease after the cavities can be manufactured to cover a different number of wells of the plate, to insert a different number of optical fibers, the optical power density introduced into the treatment of different light treatment.

附图说明 BRIEF DESCRIPTION

[0006] 图1为该光动力治疗装置的治疗图 [0006] FIG photodynamic therapy treatment device of FIG. 1 for

[0007] 图2为该装置的立体结构图 [0007] FIG 2 is the three-dimensional structure of the apparatus of FIG.

[0008] 图3左侧为该装置的正视图,右侧为正视图沿A-----A的剖面图。 [0008] The means for the left side elevational view of FIG. 3, right side cross-sectional view taken along A ----- A front view of FIG.

[0009] 图2中I为光纤、2-1为匀光板、2-2为高透明液体、2_3为高透明柔性材料具体实施方案 [0009] I is the fiber of FIG. 2, the uniform light board 2-1, 2-2 for the high-transparent liquid, transparent flexible material 2_3 high specific embodiment

[0010] 如图1所示,首先根据三维重建系统对患者病灶区域的三维重建模型得到病灶区域的平面结构模型,选取合适的(2-3)高透明柔性材料,结合(2-1)匀光板和内表面镀反光膜的挡板制作成接触面与病灶区域大小相同的封闭腔体,在前空腔内装满(2-2)高透明液体,为了提高治疗效果要求前空腔注满液体后不能有气泡,根据治疗需求选择相应数量的 [0010] As shown, the first three-dimensional reconstruction of the three-dimensional reconstruction system model of the lesion region of the patient to obtain a flat structure model lesion area, select the appropriate (2-3) highly transparent flexible material, in combination (2-1) evenly light board and the inner surface of the reflective film coating baffles made to the same contact surface with the sealed cavity lesion area size, the front cavity filled with (2-2) high transparent liquid, in order to enhance the therapeutic effect requires the front cavities filled after the liquid can not have bubbles, a corresponding number selected according to need of treatment

(I)光纤导入相应波长的治疗光源,插在后盖上(I)光纤末端离(2-1)匀光板合适位置处。 (I) corresponding fiber introduction treatment source wavelength, after inserting the cover (I) from the end of the fiber (2-1) even light board place. (2-3)高透明柔性材料恰好覆盖完体表病灶区域,使治疗光能够垂直均匀的投射在病灶区域上,治疗区域内的光照密度分布均匀,同时用(2-2)高透明液体,既能使光功率密度分布均匀,又能给病灶区域降温,使治疗过程更加舒适。 (2-3) a transparent flexible material just high surface finish coverage area of ​​the lesion, so that a uniform therapeutic light is vertically projected on the focus area, the light density within the treatment area distribution, simultaneously with (2-2) high transparent liquid, both the light power density distribution, but also to focus regional cooling, make the treatment process more comfortable.

[0011] 以上所述,仅是本发明的实施例而已,并非对本发明的结构做任何形式上的限制。 [0011] In the above, merely embodiments of the present invention, but do not form any limitation to the structure of the present invention. 凡是依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰,均仍属于本发明的技术方案的范围内。 Where any simple modifications based on the technical essence of the present invention is made to the above embodiment of the embodiment, modifications and equivalent, are still within the scope of the technical solutions of the present invention.

Claims (4)

1.一种软基适形均匀光照射光动力治疗装置,其特征在于可以根据体表病灶区域的大小和严重程度进行相适应的调整,接触面能完全贴合病灶区域,治疗光均匀照射病灶区域。 1. A soft conformable yl uniform light illumination photodynamic treatment device, characterized in that the adaptation phase may be adjusted according to the size and surface area lesion severity, the contact surface can completely fit the lesion area, the lesion area of ​​uniform illumination light therapy .
2.根据权利要求1中的一种软基适形均匀光照射光动力治疗装置,其特征在于与体表接触表面由柔性硅胶等高透明软基质材料组成。 The group A soft conformable uniform light is irradiated in PDT apparatus as claimed in claim 1, characterized in that the contact surface with the body contour of a flexible transparent soft silicone matrix material.
3.根据权利要求1中的一种软基适形均匀光照射光动力治疗装置,其特征在于治疗光源经光纤由装置后部导入,光纤数量及光源波长可由疾病严重程度决定。 The group 1 A soft conformable uniform light irradiation apparatus for photodynamic therapy, wherein the treatment device is by the rear light source into an optical fiber, the severity of the number of optical fibers and a light source wavelength may be determined as claimed in claim diseases.
4.根据权利要求1中的一种软基适形均匀光照射光动力治疗装置,其特征在于治疗光源需经匀光板和高透明液体组成的匀光系统后才能到达治疗区域。 The group 1 A soft conformable uniform light illumination photodynamic treatment device, characterized in that to reach the treatment area after the treatment of the uniform illumination system subject to uniform light source boards and high transparent liquid composition as claimed in claim.
CN201510055034.5A 2015-02-03 2015-02-03 Soft-foundation conformal uniform light irradiation photodynamics therapy device CN104548381A (en)

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EP1818077A1 (en) * 2006-02-03 2007-08-15 WaveLight AG Phototherapy device for treating the skin
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CN102716551A (en) * 2011-03-29 2012-10-10 朱建国 LED planar transparent soft-base conformal phototherapy body
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CN103380240A (en) * 2011-01-21 2013-10-30 娇韵诗实验室 Illuminated fabric, device for administering light to the skin, kit and method for implementing same
CN103623507A (en) * 2013-12-21 2014-03-12 罗建华 Medical beautifying facial mask
CN103930162A (en) * 2011-09-08 2014-07-16 拉卢米埃有限公司 Light therapy platform system
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Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743249B1 (en) * 1997-08-25 2004-06-01 Philip G. Alden Treatment device for photodynamic therapy and method for making same
WO2001023032A2 (en) * 1999-09-30 2001-04-05 Ceramoptec Industries, Inc. Device and method for application of radiation
US20050177093A1 (en) * 2002-03-04 2005-08-11 Barry Hart M. Joint / tissue inflammation therapy and monitoring device
CN1738663A (en) * 2002-11-12 2006-02-22 帕洛玛医疗技术公司 Apparatus for performing optical dermatology
EP1818077A1 (en) * 2006-02-03 2007-08-15 WaveLight AG Phototherapy device for treating the skin
CN101670152A (en) * 2009-09-10 2010-03-17 北京理工大学 Photodynamic therapy system
CN102753235A (en) * 2009-12-16 2012-10-24 皇家飞利浦电子股份有限公司 Light treatment system
CN103380240A (en) * 2011-01-21 2013-10-30 娇韵诗实验室 Illuminated fabric, device for administering light to the skin, kit and method for implementing same
CN102716551A (en) * 2011-03-29 2012-10-10 朱建国 LED planar transparent soft-base conformal phototherapy body
CN103930162A (en) * 2011-09-08 2014-07-16 拉卢米埃有限公司 Light therapy platform system
CN102784440A (en) * 2012-09-04 2012-11-21 北京理工大学 Intelligent light irradiation therapeutic apparatus
CN103623507A (en) * 2013-12-21 2014-03-12 罗建华 Medical beautifying facial mask
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