CN104548346A - Injecting type nerve stimulator with electromagnetic coupling link power supply - Google Patents
Injecting type nerve stimulator with electromagnetic coupling link power supply Download PDFInfo
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- CN104548346A CN104548346A CN201510024691.3A CN201510024691A CN104548346A CN 104548346 A CN104548346 A CN 104548346A CN 201510024691 A CN201510024691 A CN 201510024691A CN 104548346 A CN104548346 A CN 104548346A
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Abstract
The invention discloses an injecting type nerve stimulator with an electromagnetic coupling link power supply. The injecting type nerve stimulator with the electromagnetic coupling link power supply comprises a cylinder outer shell with a hollow cavity, electrodes connected with through-holes on the two ends of the outer shell in a sleeving and penetrating mode, an eye hole formed in a bulb of one of the electrode, a chargeable battery arranged inside the outer shell, a micro controller, a micro nerve stimulator module, a data receiving module, a power source management module, a biological and temperature sensor, a pressure sensor, a magnetic sensor, magnetic cores, coils and filler and the like. The position between the electrodes and the outer shell are sealed. The multiple functional modules are powered by electric energy coupled through the magnetic cores and the coils. The multiple sensors are used for monitoring environment variables and supervising the nerve stimulation process. The filler is used for the space-filling and the component-fixing. According to the injecting type nerve stimulator, an implantable nerve stimulator can be directly injected by an injector without reaching target spot nerves or muscle tissue, and the nerve stimulator is applicable to a situation which needs a long term or higher impulse amplitude stimulation.
Description
Technical field
The invention belongs to biomedical electronics Medical Instruments technical field.Relate to a kind of injection nerve stimulator, more specifically relate to the injection nerve stimulator that a kind of electromagnetic coupled link is powered.The present invention is mainly used in biologic medical, stimulates neural or muscle.
Background technology
Nerve stimulator is a kind of biologic medical electronic installation.It carries out functional nerve electricity irritation for generation of low-frequency electric pulse to organism, to reach relieving the pain caused by diseases symptom, and the effects such as the function of recovery or adjustment nerve or muscle.Nerve stimulator can by neurologist, and nurse or the technical staff through training calibrate, to meet the concrete needs of individuals patients.In the market comparative maturity and most widely used be embedded nerve stimulator.This nerve stimulator must be implanted in the health of people or other animals by surgical operation, there is following limitation: 1) embedded nerve stimulator is implanted in health the operation (needing about 12 hours as implanted brain depth stimulator) needed by the long period, patient must stand certain misery; 2) relative to the specific target nerve needing to stimulate, the size of embedded nerve stimulator is relatively large, can not be implanted in shape or the limited target nerve of volume or muscular tissue (as brain); In order to stimulus signal is conducted to brain position, need on electrode, introduce longer electrode extension lead; But electrode extension lead is easy to be moved, likely cause an electricity irritation in the position of mistake, this greatly can increase the risk of infection.And be often diffused in whole system in the infection that any part of embedded nerve stimulator is brought out, in this case, must again be changed battery or whole implantable neural stimulator by surgical operation; 3) general on Vehicles Collected from Market embedded nerve stimulator mainly uses non-charging battery to power, and electric energy can be depleted in 4 to 10 years, and now need replacing battery of again performing the operation, therefore its life cycle management is shorter; 4) implant embedded nerve stimulator after implanting, if occur uncomfortable, when needs remove or change, need again to perform the operation, the secondary injury therefore caused when injected organism tissue is larger.
Summary of the invention
The object of the invention is, in order to solve and overcome above-mentioned prior art, the technical problem especially existing for embedded nerve stimulator and defect, to provide the injection nerve stimulator that a kind of electromagnetic coupled link is powered.The injection nerve stimulator that electromagnetic coupled link of the present invention is powered, there is no relevant document introduction at present, does not also search relevant patent document.
For achieving the above object, the technical solution used in the present invention is:
The injection nerve stimulator that electromagnetic coupled link is powered, is made up of shell 1, electrode 2, rechargeable battery 3, microcontroller and micro-nerve stimulator module 4, data reception module 5, power management module 6, biology and temperature sensor 7, pressure transducer 8, Magnetic Sensor 9, magnetic core 10, coil 11, eyelet 12 and implant 13 etc.
Described shell 1 is in order to protect injection nerve stimulator and tissue mutually from the erosion of the other side.Described electrode 2 is the interfaces between injection nerve stimulator and bio-tissue.Described rechargeable battery 3 stores the electric energy that described magnetic core 10 and described coil 11 are coupled, and powers for other functional module.Described microcontroller and micro-nerve stimulator module 5 are for generation of, management and the operation controlling injection nerve stimulator; Wherein micro-nerve stimulator produces the pulse of polarity, amplitude, dutycycle and a frequency-adjustable, provides suitable electricity irritation by described electrode 2 to neural or muscular tissue; Microcontroller for managing and control the operation of injection nerve stimulator, such as, starts or stops stimulation, monitoring neurobehavioral, read data information etc.The stimulus signal information that described data reception module 5 sends for external signal transmitter of decoding, as polarity, amplitude, dutycycle and frequency etc.Electric energy after conversion is carried out rectification, filtering and voltage stabilizing etc., to drive other functional module by described power management module 6.Biosensor and temperature sensor are integrated on one module by described biology and temperature sensor 7; Wherein the former is for detecting the behavior of nerve or muscular tissue, extracts physiology in the signal of telecommunication and organism or biochemical parameter etc.; The latter is used for temperature and the temperature of interface between itself and residing tissue of perception injection nerve stimulator.Described pressure transducer 8 is for measuring the pressure change in vivo of the rear injection nerve stimulator of injection, early warning risk.Described Magnetic Sensor 9 for measuring the changes of magnetic field in body, early warning risk.Described magnetic core 10 and coil 11 are for energy and data transmission.Described eyelet 12 is in order to remove injection nerve stimulator in a short time.Described implant 13 is filled for space and parts are fixed.
Described shell 1 is for having the cylinder of cavity, and cylindrical two ends offer a through hole of coaxial line; Described electrode 2 is 2 cylinders installed respectively in through-holes, and cylindrical one end wears in the through hole being connected to shell 1, and is connected to described microcontroller and micro-nerve stimulator module 4 by plain conductor, and another elongated end termination is bulb; Described rechargeable battery 3 is cylindrical, is arranged on the left end in described shell 1 cavity, rechargeable battery 3 cylindrical outer surface is set with described magnetic core 10 and the 2 layers of described coil 11 being wrapped in described magnetic core 10 outer surface; Described Magnetic Sensor 9, power management module 6, microcontroller and micro-nerve stimulator module 4, data reception module 5, biological and temperature sensor 7 and pressure transducer 8 are from left to right in order and the mutually isolated right-hand member be placed in described shell 1 cavity; Two power connections of described rechargeable battery 3 are connected to described Magnetic Sensor 9, power management module 6, microcontroller and micro-nerve stimulator module 4, data reception module 5, biology and temperature sensor 7 and pressure transducer 8 in the mode of series connection successively; Described microcontroller and micro-nerve stimulator module 4 also have two paths of signals to be connected to described data reception module 5; The two paths of signals of described biology and temperature sensor 7, a road signal of described pressure transducer 8, and a road signal of described Magnetic Sensor 9 is all connected to described data reception module 6; First two joints of described coil 11 are connected to described power management module 6, then after Capacitance Coupled, are connected to data reception module 5; Described eyelet 12 is through holes for centerline hole and electrode 2 axis perpendicular that the bulb of arbitrary in described 2 electrodes 2 is offered.Described implant 13 fills the inner remaining space of described shell 1, and fixes its inner all parts.
The material manufacture with bio-compatibility of above-mentioned shell 1, as pottery or glass in any one, preferably ceramic; Its external diameter is less than the internal diameter of corresponding injection needle.
The conductor manufacture with bio-compatibility of above-mentioned electrode 2, as in platinum, platinum-iridium alloy, yttrium oxide, titanium nitride, silkworm silk any one, preferred platinum; The diameter of above-mentioned electrode 2 is less than the internal diameter of above-mentioned shell 1; The diameter of its bulb is greater than its cylindrical diameter.
Above-mentioned rechargeable battery 3 has high-octane rechargeable battery (as lithium ion battery etc.) by employing, and its diameter and length are less than diameter and the length of above-mentioned magnetic core 10 respectively.
Signal between above-mentioned rechargeable battery 3, microcontroller and micro-nerve stimulator module 4, data reception module 5, power management module 6, biological and temperature sensor 7, pressure transducer 8, Magnetic Sensor 9 is connected by metallic bond zygonema.
Above-mentioned magnetic core 10 adopts the manufacture of high magnetic conductivity ferrite iron core.
Above-mentioned coil 11 is manufactured by plain conductor.
The diameter of above-mentioned eyelet 12 is less than the diameter of the bulb of described electrode 2.
Above-mentioned implant 13 is any one in epoxy resin or gel, preferred epoxy.
A kind of electromagnetic coupled link of the present invention injection nerve stimulator of powering compared with prior art tool has the following advantages and beneficial effect:
The injection nerve stimulator of 1, powering due to a kind of electromagnetic coupled link of the present invention small-sized, so can be injected in target nerve or muscular tissue by syringe, and small-bore injection needle in can selecting (as 16G and following), to reduce the damage to live body muscular tissue or nerve in injection process.
The injection nerve stimulator of 2, powering due to a kind of electromagnetic coupled link of the present invention can be injected in the embedded nerve stimulator inaccessiable target nerve of institute or muscular tissue, therefore do not need electrode extension lead, thus greatly reduce the risk of infection.
The injection nerve stimulator of 3, powering due to a kind of electromagnetic coupled link of the present invention adopts electromagnetic coupled link to power, and its energy is wireless transmission, and can be stored in rechargeable battery, and therefore do not need to change battery, life cycle management is long.
The injection nerve stimulator of 4, powering due to a kind of electromagnetic coupled link of the present invention has eyelet, if therefore occur uncomfortable at the initial stage of injection, fast can remove at original mouth place, the secondary injury caused when injected organism tissue is little.
Accompanying drawing explanation
Fig. 1 is organigram of the present invention;
Fig. 2 is the interface signal connection diagram between electrode 2 and microcontroller and micro-nerve stimulator module 4;
Fig. 3 is rechargeable battery 3 and microcontroller and micro-nerve stimulator module 4, data reception module 5, power management module 6, biological and temperature sensor 7, power supply signal connection diagram between pressure transducer 8 and Magnetic Sensor 9;
Fig. 4 is microcontroller and micro-nerve stimulator module 4, data reception module 5, power management module 6, biological and temperature sensor 7, data signal connection diagram between pressure transducer 8 and Magnetic Sensor 9;
Fig. 5 is coil 11 and the interface signal connection diagram between data reception module 5 and power management module 6;
In figure: 1. shell, 2. electrode, 3. rechargeable battery, 4. microcontroller and micro-nerve stimulator module, 5. data reception module, 6. power management module, 7. biological and temperature sensor, 8. pressure transducer, 9. Magnetic Sensor, 10. magnetic core, 11. coils, 12. eyelets, 13. implants.
Detailed description of the invention
In order to deepen the understanding of the present invention, below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, and this embodiment, only for explaining the present invention, does not form the regulation to scope.
The implication of " inside and outside " described in the present invention refers to relative to nerve stimulator itself, points in the direction of nerve stimulator inside is, otherwise is outward, but not the specific restriction to nerve stimulator of the present invention.
When the implication of " left and right " described in the present invention refers to reader just to accompanying drawing, the left side of reader is a left side, and the right of reader is the right side, but not the specific restriction to nerve stimulator of the present invention.
The indirect connection that can be the direct connection between parts also can be by other parts between parts of the implication of " connection " described in the present invention.
As Fig. 1, Fig. 2, Fig. 3, shown in Fig. 4 and Fig. 5, the injection nerve stimulator that electromagnetic coupled link is powered, is made up of shell 1, electrode 2, rechargeable battery 3, microcontroller and micro-nerve stimulator module 4, data reception module 5, power management module 6, biology and temperature sensor 7, pressure transducer 8, Magnetic Sensor 9, magnetic core 10, coil 11, eyelet 12 and implant 13 etc.
Described shell 1 is for having the cylinder of cavity, and its external diameter (Φ 1) is 1 millimeter, and internal diameter is 0.9 millimeter, and length (L1) is 4 millimeters, is manufactured by pottery; The described cylindrical two ends of ceramic package 1 offer the through hole that coaxial line diameter is 0.42 millimeter, each ceramic cap placing a sealing in through hole.The bulb that described electrode 2 is 0.6 millimeter by the cylinder of diameter (Φ 21) 0.4 millimeter, length 0.4 millimeter and end diameter (Φ 22) is formed, and all adopts metal platinum manufacture; To form anelectrode and negative electrode in the circular hole that two cylindrical ends of described platinum electrode 2 are enclosed within described shell 1 ceramic cap respectively, and employing take aluminium oxide as the ceramic metal seal ring seal of primary raw material; Its anelectrode and negative electrode are connected to described microcontroller and micro-nerve stimulator module 4 by plain conductor (NS_OUT+ and NS_OUT-) respectively, as shown in Figure 2.The injection lithium ion chargeable battery that described rechargeable battery 3 adopts Qullion company of the U.S. to manufacture, its diameter is 0.6 millimeter, and length is 3 millimeters; Be placed in the left side of described shell 1 inner cylinder.Described Magnetic Sensor 9, power management module 6, microcontroller and micro-nerve stimulator module 4, data reception module 5, biological and temperature sensor 7 and pressure transducer 8 functional module from left to right successively and the mutually isolated space be placed on the right of described shell 1 inner cylinder, and all adopt the CMOS technology manufacture based on 90 nanometers.Described rechargeable battery 3, microcontroller and micro-nerve stimulator module 4, data reception module 5, power management module 6, biology and temperature sensor 7 are connected by metallic bond zygonema with pressure transducer 8, Magnetic Sensor 9 signal each other.Two power connection lines (BAT+ and BAT-) of described rechargeable battery 3 are connected to described Magnetic Sensor 9, power management module 6, microcontroller and micro-nerve stimulator module 4, data reception module 5, biology and temperature sensor 7 and pressure transducer 8 in the mode of series connection successively, as shown in Figure 3.Described microcontroller and the control between micro-nerve stimulator module 4 and data reception module 5 with communicate by I
2c bus (SDA and SCL) signal realizes; The bio signal (BIO) that described biology and temperature sensor 7 are produced and temperature signal (TEMP) input described data reception module 5; The pressure signal (PRESSURE) that described pressure transducer 8 is produced inputs described data reception module 5; The magnetic signal (MAGNETIC) that described Magnetic Sensor 9 is produced inputs described data reception module 5, as shown in Figure 4.First two joint line (WIRE+ and WIRE-) of described coil 11 are connected to described power management module 6, and then after Capacitance Coupled, (DATA_RX+ and DATA_RX-) is connected to data reception module 5, as shown in Figure 5.Described magnetic core 10 is made up of the semicylinder high magnetic conductivity ferrite iron core of two pieces of hollows, and its external diameter is 0.85 millimeter, and internal diameter is 0.75 millimeter, and length is 3.2 millimeters; Described magnetic core 10 is sleeved on described rechargeable battery 3.The thin copper wire that described coil 11 is 50 microns by diameter divides the two-layer outer surface being wrapped in described magnetic core 10, and its two joints are connected with described power management module 6, as shown in Figure 3.Described eyelet 12 is through holes for centerline hole and electrode 2 axis perpendicular that the bulb of arbitrary in described 2 electrodes 2 is offered, and its diameter (Φ 12) is 0.1 millimeter.Described implant 13 adopts epoxy resin, fills the inner remaining space of described shell 1, and fixes its inner other parts all.All parts being loaded after in described shell 1, the ceramic cap of described shell 1 being enclosed within its cylindrical end and sealing, and seal with O shape ceramic seal circle and ceramic seal glue.
Above embodiment, is only the present invention's preferably detailed description of the invention.Certainly; the present invention also can have other various embodiments, when not deviating from the present invention's spirit and essence thereof, is anyly familiar with those skilled in the art; when various corresponding equivalent arrangements can be made according to the present invention, the protection domain of the claim appended by the present invention all should be belonged to.
The diameter of the injection nerve stimulator that a kind of electromagnetic coupled link of the present invention is powered and length all very little, can small-bore injection needle by syringe and in selecting (as 16G and following), by its direct injection in the embedded nerve stimulator inaccessiable target nerve of institute or muscular tissue, and can fast remove.The present invention had both been applicable to the occasion needing long-time stimulus, was also applicable to the occasion needing to stimulate compared with high impulse amplitude.
Claims (10)
1. an electromagnetic coupled link injection nerve stimulator of powering, comprises shell (1), electrode (2), rechargeable battery (3), microcontroller and micro-nerve stimulator module (4), data reception module (5), power management module (6), biological and temperature sensor (7), pressure transducer (8), Magnetic Sensor (9), magnetic core (10) and coil (11); It is characterized in that: described shell (1) is for having the cylinder of cavity, and cylindrical two ends offer a through hole of coaxial line; Described electrode (2) is install 2 cylinders in through-holes respectively, cylindrical one end wears in the through hole being connected to shell (1), and being connected to described microcontroller and micro-nerve stimulator module (4) by plain conductor, another elongated end termination is bulb; Described rechargeable battery (3) is for cylindrical, be arranged on the left end in described shell (1) cavity, rechargeable battery (3) cylindrical outer surface be set with described magnetic core (10) and be wrapped in 2 layers of described coil (11) of described magnetic core (10) outer surface; Described Magnetic Sensor (9), power management module (6), microcontroller and micro-nerve stimulator module (4), data reception module (5), biological and temperature sensor (7) and pressure transducer (8) are from left to right in order and the mutually isolated right-hand member be placed in described shell (1) cavity; Two power connections of described rechargeable battery (3) are connected to described Magnetic Sensor (9), power management module (6), microcontroller and micro-nerve stimulator module (4), data reception module (5), biology and temperature sensor (7) and pressure transducer (8) in the mode of series connection successively; Described microcontroller and micro-nerve stimulator module (4) also have two paths of signals to be connected to described data reception module (5); The two paths of signals of described biology and temperature sensor (7), a road signal of described pressure transducer (8) and a road signal of described Magnetic Sensor (9) are all connected to described data reception module (6); Two joints of described coil (11) are first connected to described power management module (6), after Capacitance Coupled, be then connected to data reception module (5).
2. the electromagnetic coupled link according to claim 1 injection nerve stimulator of powering, is characterized in that: be also provided with the implant (13) for fixing described Magnetic Sensor (9), power management module (6), microcontroller and micro-nerve stimulator module (4), data reception module (5), biological and temperature sensor (7) and pressure transducer (8) in the cavity of described shell (1).
3. the electromagnetic coupled link according to claim 1 injection nerve stimulator of powering, is characterized in that: the eyelet (12) bulb of arbitrary in described 2 electrodes (2) also offering centerline hole and electrode (2) axis perpendicular.
4. the electromagnetic coupled link according to claim 1 injection nerve stimulator of powering, is characterized in that: described magnetic core (10) is made up of the semicylinder of two pieces of hollows, adopts the manufacture of high magnetic conductivity ferrite iron core.
5. the electromagnetic coupled link according to claim 1 and 2 injection nerve stimulator of powering, is characterized in that: the material of described shell (1) in pottery or glass any one, preferably ceramic.
6. the injection nerve stimulator that the electromagnetic coupled link according to claim 1 or 3 is powered, is characterized in that: the material of described electrode (2) is any one in platinum, platinum-iridium alloy, yttrium oxide, titanium nitride, silkworm silk, preferred platinum.
7. the injection nerve stimulator that the electromagnetic coupled link according to claim 1,3 or 6 is powered, is characterized in that: described electrode (2) cylindrical diameter is less than the internal diameter of described shell (1); Its bulb diameter is greater than its cylindrical diameter.
8. the electromagnetic coupled link according to claim 1 injection nerve stimulator of powering, is characterized in that: described rechargeable battery (3) is for having high-octane lithium ion battery.
9. the electromagnetic coupled link according to claim 1 injection nerve stimulator of powering, is characterized in that: described coil (11) is plain conductor structure.
10. the electromagnetic coupled link according to claim 2 injection nerve stimulator of powering, is characterized in that: described implant (13) in epoxy resin or gel any one, preferred epoxy.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018094342A1 (en) * | 2016-11-21 | 2018-05-24 | Cardiac Pacemakers, Inc | Implantable medical device with a magnetically permeable housing and an inductive coil disposed about the housing |
| US10918875B2 (en) | 2017-08-18 | 2021-02-16 | Cardiac Pacemakers, Inc. | Implantable medical device with a flux concentrator and a receiving coil disposed about the flux concentrator |
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| US20120245652A1 (en) * | 2000-08-18 | 2012-09-27 | Boston Scientific Neuromodulation Corporation | Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction |
| CN104107507A (en) * | 2014-07-09 | 2014-10-22 | 庞德兴 | Passive minimally-invasive subcutaneous nerve interventional chip based on RFID radio frequency technology |
| WO2014205407A2 (en) * | 2013-06-22 | 2014-12-24 | Micron Devices Llc | Methods and devices for the selective modulation of excitable tissue |
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Patent Citations (4)
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| US20120245652A1 (en) * | 2000-08-18 | 2012-09-27 | Boston Scientific Neuromodulation Corporation | Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction |
| CN101773701A (en) * | 2010-01-11 | 2010-07-14 | 杭州诺尔康神经电子科技有限公司 | Nerve stimulator |
| WO2014205407A2 (en) * | 2013-06-22 | 2014-12-24 | Micron Devices Llc | Methods and devices for the selective modulation of excitable tissue |
| CN104107507A (en) * | 2014-07-09 | 2014-10-22 | 庞德兴 | Passive minimally-invasive subcutaneous nerve interventional chip based on RFID radio frequency technology |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2018094342A1 (en) * | 2016-11-21 | 2018-05-24 | Cardiac Pacemakers, Inc | Implantable medical device with a magnetically permeable housing and an inductive coil disposed about the housing |
| US11147979B2 (en) | 2016-11-21 | 2021-10-19 | Cardiac Pacemakers, Inc. | Implantable medical device with a magnetically permeable housing and an inductive coil disposed about the housing |
| US10918875B2 (en) | 2017-08-18 | 2021-02-16 | Cardiac Pacemakers, Inc. | Implantable medical device with a flux concentrator and a receiving coil disposed about the flux concentrator |
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| CN104548346B (en) | 2017-02-22 |
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Effective date of registration: 20201222 Address after: Room 502-2, building 5, No. 49, Wengang South Road, Yannan high tech Zone, Yancheng City, Jiangsu Province 224000 (CNx) Patentee after: YANCHENG YIDONG TECHNOLOGY SERVICE Co.,Ltd. Address before: Meng Xi Road 212003 Zhenjiang city of Jiangsu province Jingkou District No. 2 Patentee before: JIANGSU University OF SCIENCE AND TECHNOLOGY Effective date of registration: 20201222 Address after: Room 206 (CNx), xifuhe digital intelligent innovation community Exhibition Center building, 49 Wengang South Road, Yannan high tech Zone, Yancheng City, Jiangsu Province Patentee after: Yancheng Yannan high tech Zone xifuhe digital intelligent industry development Co.,Ltd. Address before: Room 502-2, building 5, No. 49, Wengang South Road, Yannan high tech Zone, Yancheng City, Jiangsu Province 224000 (CNx) Patentee before: YANCHENG YIDONG TECHNOLOGY SERVICE Co.,Ltd. |