CN104546838B - Tablet and preparation method thereof - Google Patents
Tablet and preparation method thereof Download PDFInfo
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- CN104546838B CN104546838B CN201410822886.8A CN201410822886A CN104546838B CN 104546838 B CN104546838 B CN 104546838B CN 201410822886 A CN201410822886 A CN 201410822886A CN 104546838 B CN104546838 B CN 104546838B
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- amoxicillin
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Abstract
The present invention relates to a kind of tablet and preparation method thereof, tablet is composed of the following components according to mass percent：Amoxicillin 15%~30%, potassium clavulanate mixture 5%~15%, filler 30%~65%, crospovidone 1.5%~8%, PVP K30 0.6%~3%, silica 1 %~3%, Compritol 888 ATO 1%~5%；PVP K30 adds in absolute ethyl alcohol and configures composite adhesives；First Amoxicillin, filler, crospovidone are added in granulator and mixed, adhesive is added in mixed process；The amoxicillin granules prepared are added mixer with potassium clavulanate mixture, silica and Compritol 888 ATO again to mix, are discharged, tabletting.The tablet of the present invention is pelletized using half wet process, is remained to so that potassium clavulanate is not degradable, effectively the stability of guarantee medicine.
Description
It is on July 16th, 2013 applying date that the application, which is, Application No. 201310297361.2, entitled " compound
The divisional application of amoxicillin and clavulanate potassium tablets and preparation method thereof ".
Technical field
The present invention relates to the preparation process of a kind of medicine and the medicine, especially a kind of tablet, belongs to pharmaceutical preparation skill
Art field.
Background technology
The compound preparation that amoxicillin and clavulanate potassium tablets are made of Amoxicillin and potassium clavulanate, Ah therein
Amdinocillin is spectrum penicillin antibiotics, and potassium clavulanate only has faint antibacterial activity in itself, but has powerful spectrum
Beta-lactam enzyme hydrolysis.In-vitro antibacterial research shows that clavulanic acid can improve Amoxicillin to Klebsiella common variation bar
4~32 times of the antibacterial activity of the minority enteron aisle producing enzyme bacillus such as bacterium, improves 32 times of the antibacterial activity to Hemophilus influenzae, improves Ah not
Antibacterial activity 4~32 times of the XiLin to that Moraxella of card.Clinical practice also indicates that amoxicillin and clavulanate potassium compound preparation expands
The big antibiotic property of Amoxicillin, strengthens its antibacterial strength, has the advantages that good effect, incidence of side effects are relatively low, into
For in caused by clinical treatment producing enzyme drug-fast bacteria and sensitive bacteria, the preferred antibiotics of severe infection.
Clinically the most commonly used amoxicillin and clavulanate potassium compound preparation is oral tablet at present.In the market Ah Moses
Woods potassium clavulanate oral tablet is first to mix Amoxicillin with potassium clavulanate mostly, is then mixed again with other auxiliary materials
Technique.The preparation method of tablet is divided into wet granule compression tablet method and compressing dry granulation, wet granule compression tablet by preparation process
Method is the method that prepared by the addition liquid adhesive of the powder of medicine and auxiliary material after mixing particle, due to potassium clavulanate
Easily decompose, so traditional wet granule compression tablet method is not suitable for the preparation of amoxicillin clavulanate potassium tablets.
Chinese patent literature CN200810212280.7 discloses a kind of amoxicillin/clavulanate potassium 8: 1 and its system
Preparation Method.8: 1 tablet of amoxicillin/clavulanate potassium, be with the good Amoxicillin of quality controllability, mixture homogeneity/gram
Blended stock is main ingredient source among clavulanic acid potassium (8: 1), and the preparation method technique is relatively simple.
Chinese patent literature CN200910074500.9 discloses a kind of preparation side of amoxicillin and clavulanate potassium tablets
Method, 120~135 parts of Amoxicillin, 40~45 parts of potassium clavulanate, 27~32 parts of microcrystalline cellulose, cross-linked carboxymethyl cellulose
1~3 part of sodium, 1~3 part of superfine silica gel powder, 2~4 parts of magnesium stearate；After Amoxicillin is pelletized, according to 4: 1 mass ratio, with gram
Clavulanic acid potassium mixes, and forms major ingredient；By auxiliary material superfine silica gel powder, Ac-Di-Sol (ADS) and microcrystalline cellulose according to
Equivalent gradually-increased mixes, then progressively increases to put into mixer with major ingredient equivalent and mix 36~70 minutes；Mixed powder is subjected to tabletting.Should
After preparation method mixes amoxicillin granules with potassium clavulanate, then add all auxiliary materials with equivalent gradually-increased and mixed,
Incorporation time is longer, and charging requires more stringent, the stability of technique not easy to control.
Both the above is all typical compressing dry granulation, is widely used in amoxicillin clavulanate potassium tablet
The preparation of agent, but compressing dry granulation production tablet due to high pressure can cause crystal transfer and activity reduce, to tablet
Stability have an impact, in addition, be also particularly easy to produce capping, sticking phenomena such as, tablet appearance condition is undesirable.
The content of the invention
The technical problem to be solved in the present invention is propose that one kind uses wet granulation, remain to so that potassium clavulanate is not easy
Degraded, effectively ensures the amoxicillin clavulanate potassium tablets of the stability of medicine, and a kind of technique is simple, operation
Simplicity, controllability are good, can guarantee that the preparation method of the amoxicillin clavulanate potassium tablets of tablet surface smooth and beautiful appearance.
The present invention is to solve the technical solution that above-mentioned one of technical problem proposes to be：A kind of amoxicillin carat
The sour potassium tablets of dimension, it is composed of the following components according to mass percent：Amoxicillin 15%~30%, potassium clavulanate mixture
5%~15%, filler 30%~65%, crospovidone 1.5%~8%, PVP K30 0.6%~3%, silica
1%~3%, Compritol 888 ATO 1%~5%；The mass ratio of the Amoxicillin and potassium clavulanate is 1: 1 to 10: 1.Gram
Clavulanic acid potassium mixture is the mixture mixed by potassium clavulanate and microcrystalline cellulose according to mass ratio 1: 1.
In order to enable the Color uniformity of tablet is good, there is color and luster, surface is speckless, and a kind of preferable technical solution is：
Colouring agent is further included in said components, the mass percentage content of the colouring agent is 0.05%~1%.
In order to enable when the tablet is as animal chew piece, there is preferably taste, facilitate animal to take, it is a kind of preferable
Technical solution is：The mass percentage content of above-mentioned essence is 1%~5%.
In order to enable the compressing stability higher of the tablet, a kind of preferable technical solution are：Above-mentioned filler is
The mass ratio of one or both of microcrystalline cellulose and calcium monohydrogen phosphate, the Amoxicillin and potassium clavulanate is 4: 1.
The present invention is to solve the technical solution that another above-mentioned technical problem proposes to be：A kind of amoxicillin carat dimension
The preparation method of sour potassium tablets, comprises the following steps：
A. dispensing：Raw material is weighed, the tablet is composed of the following components according to mass percent：Amoxicillin 15%~
30%, potassium clavulanate mixture 5%~15%, filler 30%~65%, crospovidone 1.5%~8%, povidone
K300.6%~3%, silica 1 %~3%, Compritol 888 ATO 1%~5%；The Amoxicillin and potassium clavulanate
Mass ratio be 1: 1 to 10: 1；The PVP K30, which all adds, fully dissolves configuration composite adhesives in absolute ethyl alcohol, described
The gross mass of adhesive accounts for the 25%~30% of raw material gross mass；
B. Amoxicillin is pelletized：Amoxicillin, filler, crospovidone are added in granulator and mixed 3 to 8 minutes,
The adhesive configured is added in mixed process, is dried after completion granulation, whole grain, amoxicillin granules is made；
C. it is total mixed：By the amoxicillin granules prepared and potassium clavulanate mixture, silica and behenyl acid glycerol
Ester is added in mixer, and mixing discharges after 8 to 12 minutes；
D. tabletting.
In order to enable the Color uniformity of tablet is good, there is color and luster, surface is speckless, and a kind of preferable technical solution is：
Colouring agent is further included in the component of above-mentioned tablet, the mass percentage content of the colouring agent is 0.05%~1%, and colouring agent exists
When configuring adhesive, all add in adhesive, and fully dissolve.
In order to enable when the tablet is as animal chew piece, there is preferably taste, facilitate animal to take, it is a kind of preferable
Technical solution is：Essence is further included in the component of above-mentioned tablet, the mass percentage content of the essence is 1%~5%, described
Essence together adds mixed in total mix with amoxicillin granules, potassium clavulanate mixture, silica and Compritol 888 ATO
Conjunction machine is mixed.
In order to enable the compressing stability higher of the tablet, a kind of preferable technical solution are：Above-mentioned filler is
The mass ratio of one or both of microcrystalline cellulose and calcium monohydrogen phosphate, the Amoxicillin and potassium clavulanate is 4: 1.
In order to ensure the quality of tablet, a kind of preferable technical solution is：It is dry when in Amoxicillin, granulation is dried
It is less than 3.0% to moisture.
A kind of technical solution is further preferred that：Above-mentioned colouring agent is red ferric oxide, the essence be beef flavor,
Chicken meat flavor or essence with pork taste, the savory essence of preferably beef.
The good effect that the present invention has：
(1) lubricant is added in amoxicillin clavulanate potassium tablets of the invention, lubricant refers to reduce
The auxiliary material of frictional force between particle or tablet and die wall.The tablet of the present invention is as used magnesium stearate as lubricant, due to hard
Fatty acid magnesium has stronger hydrophobicity, and contact angle is 121 °, such as improper use, can make the hydrophobicity of tablet strengthen, and influences water wetting
Tablet, slows down the disintegration of tablet and the dissolution rate of medicine, can also increase the hardness of tablet, so magnesium stearate is used for compound Ah not
With certain limitation during the clavulanate potassium tablets of XiLin.The tablet of the present invention using Compritol 888 ATO as lubricant,
In the case where opposite incorporation time is shorter, Compritol 888 ATO has adhesion characteristic, can still be effectively reduced tablet by die hole
Power needed for middle release, improves the compressibility in tablet and capsule manufacture, and on disintegration time and insoluble drug release without influence.
Compritol 888 ATO can prevent that frictional force is big and makes tabletting difficult；Pressure during tabletting is evenly distributed, and make the density of tablet
Uniformly；Tablet is reduced by the power needed for being released in die hole；It can in addition contain improve the appearance of tablet, make tablet surface it is bright,
It is smooth.
(2) the Amoxicillin granulation in amoxicillin clavulanate potassium tablets of the invention uses wet granulation work
Skill, adhesive are added in absolute ethyl alcohol to configure and formed by PVP K30, and absolute ethyl alcohol volatilizees in preparation process, therefore
The preparation process of the tablet is more succinct, and Forming Quality is more preferable.
(3) formula of amoxicillin clavulanate potassium tablets of the invention is by selecting suitable crospovidone to make
It is disintegrant, suitable PVP K30 as adhesive, suitable silica is as glidant, suitable behenyl acid glycerol
Ester reduces potassium clavulanate and degrades in wet granulation, tablet yield rate is high, and tablet quality is stablized, medicine as lubricant
Stability is high.
(4) preparation method of amoxicillin clavulanate potassium tablets of the invention first by disintegrant, filler and Ah
Amoxicillin granules are made by wet granulation in Amdinocillin powder, then by amoxicillin granules, potassium clavulanate mixture, help stream
Agent and mix lubricant carry out tabletting, and technique is simple, easy to operate, and raw material incorporation time is shorter, while more importantly can be with
The degraded of potassium clavulanate has been efficiently controlled, has ensured the stability of medicine, the appearance of tablet, water compared with dry method direct tablet compressing
Point, tablet weight variation and its stability it is also more excellent.
Embodiment
(embodiment 1)
During the amoxicillin clavulanate potassium tablets tabletting of the present embodiment the quality control of every 180 ±
13.5mg, forms per tablet according to following component and dosage configuration：
Potassium clavulanate mixture is the mixing mixed by potassium clavulanate and microcrystalline cellulose according to mass ratio 1: 1
Thing.Crospovidone, red ferric oxide and absolute ethyl alcohol configuration composite adhesives add in tablet manufacture, and absolute ethyl alcohol is in piece
Volatilize in agent preparation process, in tablet into kind without residue.
The preparation method of the amoxicillin clavulanate potassium tablets of the present embodiment, including step in detail below：
A. dispensing：Suitable Amoxicillin powder, potassium clavulanate mixture, microcrystalline cellulose are weighed according to formula dosage
Element, calcium monohydrogen phosphate, crospovidone, silica, Compritol 888 ATO and beef flavor, and sieve respectively.Configure 50mg
Adhesive, adhesive adds the PVP K-30 for accounting for adhesive gross mass 5% and to account for adhesive total using absolute ethyl alcohol as solvent
0.2% red ferric oxide of quality is stirred, spare after PVP K-30 and red ferric oxide fully dissolve.
B. Amoxicillin is pelletized：By the Amoxicillin powder configured, microcrystalline cellulose, calcium monohydrogen phosphate, crospovidone
Add in granulator and mix 5 minutes, the adhesive configured is slowly added into mixed process, done after completing granulation
It is dry, until moisture is less than 3.0%, whole grain is finally carried out, amoxicillin granules are made.
C. it is total mixed：By the amoxicillin granules prepared and the potassium clavulanate mixture configured, silica, behenyl
Acid glyceride and beef flavor are added in three-dimensional motion mixer, and mixing discharges after ten minutes.
D. tabletting：According to the content calculation piece weight of main ingredient component in particle, raw material is pressed into the piece of 180 ± 13.5mg
Agent.
E. pack：Packed using double aluminium foils.
Between mixing in stringent control production process, between granulation, between tabletting, the humidity and temperature of make-up room.
(embodiment 2)
The remainder of the amoxicillin clavulanate potassium tablets of the present embodiment is same as Example 1, difference
It is：
The quality control of every is formed in 900 ± 45mg, every tablet according to following component and dosage configuration during tabletting：
The remainder of the preparation method of the amoxicillin clavulanate potassium tablets of the present embodiment and 1 phase of embodiment
Together, difference is：Be in step B will configure Amoxicillin powder, microcrystalline cellulose, calcium monohydrogen phosphate, the poly- dimension of crosslinking
Ketone is added in granulator and mixed 8 minutes.It is that the amoxicillin granules that will be prepared are mixed with the potassium clavulanate configured in step C
Compound, silica, Compritol 888 ATO and beef flavor are added in three-dimensional motion mixer, and mixing discharges after 12 minutes.
Raw material is pressed into the tablet of 900 ± 45mg in step D.
(embodiment 3)
The remainder of the amoxicillin clavulanate potassium tablets of the present embodiment is same as Example 1, difference
It is：
The quality control of every is in 1800 ± 36mg during tabletting, per tablet according to following component and dosage configuration and
Into：
The remainder of the preparation method of the amoxicillin clavulanate potassium tablets of the present embodiment and 1 phase of embodiment
Together, difference is：Be in step B will configure Amoxicillin powder, microcrystalline cellulose, calcium monohydrogen phosphate, the poly- dimension of crosslinking
Ketone is added in granulator and mixed 3 minutes.It is that the amoxicillin granules that will be prepared are mixed with the potassium clavulanate configured in step C
Compound, silica, Compritol 888 ATO and beef flavor are added in three-dimensional motion mixer, and mixing discharges after 8 minutes.Step
Raw material is pressed into the tablet of 1800 ± 36mg in rapid D.
(embodiment 4)
The remainder of the amoxicillin clavulanate potassium tablets of the present embodiment is same as Example 1, difference
It is：
Formed per tablet according to following component and dosage configuration：
Embodiment 5
The remainder of the amoxicillin clavulanate potassium tablets of the present embodiment is same as Example 1, difference
It is：
Formed per tablet according to following component and dosage configuration：
(comparative example 1)
During the amoxicillin clavulanate potassium tablets tabletting of this comparative example the quality control of every 180 ±
13.5mg, forms per tablet according to following component and dosage configuration：
Potassium clavulanate mixture is the mixing mixed by potassium clavulanate and microcrystalline cellulose according to mass ratio 1: 1
Thing.
The preparation method of the amoxicillin clavulanate potassium tablets of this comparative example, including step in detail below：
A. suitable Amoxicillin powder, potassium clavulanate mixture, microcrystalline cellulose, crosslinking are weighed according to formula dosage
Povidone, silica, Compritol 888 ATO and beef flavor, and sieve respectively.
B. the Amoxicillin powder configured and potassium clavulanate mixture are mixed into major ingredient, by microcrystalline cellulose, phosphorus
Sour hydrogen calcium, crospovidone are mixed according to equivalent gradually-increased, then with major ingredient equivalent progressively increase input granulator in mix 30 minutes with
On.
C. discharge, tabletting, packaging.
(comparative example 2)
During the amoxicillin clavulanate potassium tablets tabletting of this comparative example the quality control of every 180 ±
13.5mg, forms per tablet according to following component and dosage configuration：
The preparation method of the amoxicillin clavulanate potassium tablets of this comparative example, including step in detail below：
A. suitable Amoxicillin powder, potassium clavulanate mixture, microcrystalline cellulose, phosphoric acid are weighed according to formula dosage
Hydrogen calcium, crospovidone, silica, Compritol 888 ATO and beef flavor, and sieve respectively.Configure the bonding of 50ml
Agent, adhesive add the PVP K-30 for accounting for adhesive gross mass 5% and account for adhesive gross mass using absolute ethyl alcohol as solvent
0.2% red ferric oxide is stirred, spare after PVP K-30 and red ferric oxide fully dissolve.
B. it is the Amoxicillin powder configured, potassium clavulanate mixture, microcrystalline cellulose, calcium monohydrogen phosphate, crosslinking is poly-
Dimension ketone, which is added in granulator, to be mixed 5 minutes, and the adhesive configured is slowly added into mixed process, is carried out after completing granulation
It is dry, until moisture is less than 3.0%, finally carry out whole grain.
C. it is total mixed, the particle prepared the and silica configured, Compritol 888 ATO and beef flavor are added
In three-dimensional motion mixer, mixing discharges after ten minutes.
D. tabletting, packaging.
(comparative example 3)
The remainder of the amoxicillin clavulanate potassium tablets of this comparative example is same as Example 1, difference
Be in：Lubricant in formula instead of Compritol 888 ATO using magnesium stearate.
The quality control of every is in 180 ± 13.5mg during tabletting, per tablet according to following component and dosage configuration and
Into：
The preparation method of the amoxicillin clavulanate potassium tablets of the present embodiment is same as Example 1.
According to《Chinese Pharmacopoeia》In (two editions) annex XIXC in 2005《Bulk pharmaceutical chemicals and the important investigation item of pharmaceutical preparation stability
Mesh reference table》The project of listed corresponding formulation, 40 DEG C are placed on by the sample of each embodiment and comparative example, relative humidity 65%
The accelerated test of 3 months is carried out under environment, detects the appearance of sample, tablet weight variation, content, related material and dissolution rate, and with 0
It data compare.Each embodiment and comparative example the results are shown in Table 1.
The result of the test of the sample of 1 each embodiment of table and comparative example
Knowable to comparative example 3 and each embodiment are contrasted, in as a result of magnesium stearate as lubricant, cause
The piece hardness of the formula is big, and the dissolution rate of medicine is slow, and employs Compritol 888 ATO as lubricant, adds suitable behenyl
Acid glyceride has the effect of adhesive concurrently, can effectively improve the compressibility of tablet, to disintegration time and insoluble drug release without shadow
Ring.
Knowable to comparative example 2 and each embodiment are contrasted, the impurity in the tablet of comparative example 2 is substantially than each embodiment
Impurity is more, and after the accelerated test of 3 months, the impurity in the tablet of comparative example 2 is more obvious.In addition, the carat of comparative example 2
The sour dissolution rate of dimension is significantly lower than the clavulanic acid dissolution rate of each embodiment, and after the accelerated test of 3 months, clavulanic acid contains
Amount significantly reduces, and degraded is extremely serious, it follows that wet granulation directly results in clavulanic acid degradable, stability of drug products
Decline.
Knowable to comparative example 1 and each embodiment are contrasted, using dry method direct tablet compressing, sliver, and piece weight are easily produced
Difference is big, the content heterogeneity of clavulanic acid and Amoxicillin in sample.And the sample appearance of embodiment 1 to 5, moisture, piece weight
The result of difference and its stability is substantially better than comparative example 1, it is shown that the superiority of formula and technique.
Amoxicillin clavulanate potassium tablets of the present invention and preparation method thereof are not limited to the various embodiments described above, on
State embodiment and be only intended to clearly illustrate example of the present invention, and be not the restriction to embodiments of the present invention.
For those of ordinary skill in the field, other various forms of changes can also be made on the basis of the above description
Or change.There is no necessity and possibility to exhaust all the enbodiments.And these spirit for belonging to the present invention are extended out
Obvious changes or variations still in protection scope of the present invention among.
Claims (3)
1. a kind of preparation method of tablet, it is characterised in that comprise the following steps：
A. dispensing：Raw material is weighed, the tablet is composed of the following components according to mass percent：Amoxicillin 15%~30%, gram
Clavulanic acid potassium mixture 5%~15%, filler 55%~65%, crospovidone 1.5%~8%, PVP K30 0.6%~3%, two
The sum of silica 1%~3%, Compritol 888 ATO 1%~5%, content percentage of each component are 100%；The potassium clavulanate mixes
Compound is the mixture mixed by potassium clavulanate and microcrystalline cellulose according to mass ratio 1: 1；The Amoxicillin with gram
The mass ratio of clavulanic acid potassium is 1: 1 to 10: 1；The PVP K30 all adds fully to dissolve in absolute ethyl alcohol and is configured to bond
Agent, the gross mass of described adhesive account for the 25%~30% of raw material gross mass；
B. Amoxicillin is pelletized：Amoxicillin, filler, crospovidone are added in granulator and mixed 3 to 8 minutes, mixed
Prepared adhesive is added during conjunction, is dried after completion granulation, whole grain, amoxicillin granules is made；In A Moxi
When woods granulation is dried, drying to moisture is less than 3.0%；
C. it is total mixed：The amoxicillin granules prepared and potassium clavulanate mixture, silica and Compritol 888 ATO are added
Enter in mixer, mixing discharges after 8 to 12 minutes；
D. tabletting.
2. the preparation method of tablet according to claim 1, it is characterised in that：The filler is microcrystalline cellulose and phosphorus
One or both of sour hydrogen calcium, the mass ratio of the Amoxicillin and potassium clavulanate is 4: 1.
A kind of 3. tablet made of preparation method as claimed in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410822886.8A CN104546838B (en) | 2013-07-16 | 2013-07-16 | Tablet and preparation method thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310297361.2A CN103340855B (en) | 2013-07-16 | 2013-07-16 | Compound amoxicillin and clavulanate potassium tablet and preparation method thereof |
| CN201410822886.8A CN104546838B (en) | 2013-07-16 | 2013-07-16 | Tablet and preparation method thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310297361.2A Division CN103340855B (en) | 2013-07-16 | 2013-07-16 | Compound amoxicillin and clavulanate potassium tablet and preparation method thereof |
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| CN104546838A CN104546838A (en) | 2015-04-29 |
| CN104546838B true CN104546838B (en) | 2018-05-01 |
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| CN113274357B (en) * | 2021-05-28 | 2022-12-27 | 广州白云山医药集团股份有限公司白云山制药总厂 | Amoxicillin medicine and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1681497A (en) * | 2002-07-16 | 2005-10-12 | 兰贝克赛实验室有限公司 | Dispersible tablets for oral administration |
| WO2006066930A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Stable pharmaceutical composition comprising amoxicillin and clavulanic acid |
| CN101502511A (en) * | 2008-09-09 | 2009-08-12 | 山东淄博新达制药有限公司 | Amoxicillin/clavulanate potassium tablet and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240285A (en) * | 2011-04-21 | 2011-11-16 | 南京仕必得生物技术有限公司 | Amoxicillin and potassium clavulanate tablet for dogs and cats, and its preparation method and application |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1681497A (en) * | 2002-07-16 | 2005-10-12 | 兰贝克赛实验室有限公司 | Dispersible tablets for oral administration |
| WO2006066930A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Stable pharmaceutical composition comprising amoxicillin and clavulanic acid |
| CN101502511A (en) * | 2008-09-09 | 2009-08-12 | 山东淄博新达制药有限公司 | Amoxicillin/clavulanate potassium tablet and preparation method thereof |
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| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 201500 Jinshan District, Shanghai Golden Road 855 Lane 14, 4, 1-3 floors. Patentee after: Shanghai Hanwei Bio-Pharmaceutical Technology Co., Ltd. Address before: 201203 4 floor, 12 tower 899, Zu Chong Road, Zhangjiang High Tech Park, Pudong New Area, Shanghai Patentee before: Shanghai Hanwei Bio-Pharmaceutical Technology Co., Ltd. |