CN104530097B - Double triazole-tetrafluoro boric acid copper complex of anthracene nucleus with catalysis phenyl boric acid and preparation method thereof - Google Patents
Double triazole-tetrafluoro boric acid copper complex of anthracene nucleus with catalysis phenyl boric acid and preparation method thereof Download PDFInfo
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- CN104530097B CN104530097B CN201410769464.9A CN201410769464A CN104530097B CN 104530097 B CN104530097 B CN 104530097B CN 201410769464 A CN201410769464 A CN 201410769464A CN 104530097 B CN104530097 B CN 104530097B
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- triazole
- boric acid
- tatrz
- base
- anthracene
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- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 150000001454 anthracenes Chemical class 0.000 title claims abstract description 10
- -1 triazole-tetrafluoro boric acid copper Chemical compound 0.000 title claims abstract description 6
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 238000006555 catalytic reaction Methods 0.000 title abstract description 11
- 239000010949 copper Substances 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000005859 coupling reaction Methods 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000007809 chemical reaction catalyst Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000003054 catalyst Substances 0.000 claims description 11
- 239000013078 crystal Substances 0.000 claims description 11
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 230000005260 alpha ray Effects 0.000 claims description 3
- 239000004305 biphenyl Substances 0.000 claims description 3
- 235000010290 biphenyl Nutrition 0.000 claims description 3
- 229910002804 graphite Inorganic materials 0.000 claims description 3
- 239000010439 graphite Substances 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 2
- 239000012074 organic phase Substances 0.000 claims description 2
- 239000003208 petroleum Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 241000638935 Senecio crassissimus Species 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 20
- 150000003852 triazoles Chemical class 0.000 description 15
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 150000004699 copper complex Chemical class 0.000 description 10
- 229910052763 palladium Inorganic materials 0.000 description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 10
- 238000003786 synthesis reaction Methods 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 7
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical class C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 6
- 229910052723 transition metal Inorganic materials 0.000 description 6
- 150000003624 transition metals Chemical class 0.000 description 6
- BRUOAURMAFDGLP-UHFFFAOYSA-N 9,10-dibromoanthracene Chemical compound C1=CC=C2C(Br)=C(C=CC=C3)C3=C(Br)C2=C1 BRUOAURMAFDGLP-UHFFFAOYSA-N 0.000 description 5
- 229960004643 cupric oxide Drugs 0.000 description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 description 5
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 150000004696 coordination complex Chemical class 0.000 description 4
- 150000002460 imidazoles Chemical class 0.000 description 4
- 239000002798 polar solvent Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 229910017981 Cu(BF4)2 Inorganic materials 0.000 description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 2
- 206010054949 Metaplasia Diseases 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 238000006880 cross-coupling reaction Methods 0.000 description 2
- 238000002447 crystallographic data Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052748 manganese Inorganic materials 0.000 description 2
- 239000011572 manganese Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 150000001455 metallic ions Chemical class 0.000 description 2
- 230000015689 metaplastic ossification Effects 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 150000003217 pyrazoles Chemical class 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229910052703 rhodium Inorganic materials 0.000 description 2
- 239000010948 rhodium Substances 0.000 description 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 2
- 229910052707 ruthenium Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- ZXBVATFSHBMXOL-UHFFFAOYSA-N copper;2h-triazole Chemical compound [Cu].C=1C=NNN=1 ZXBVATFSHBMXOL-UHFFFAOYSA-N 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000005564 crystal structure determination Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000001027 hydrothermal synthesis Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000005311 nuclear magnetism Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
- B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
- B01J31/181—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine
- B01J31/1815—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine with more than one complexing nitrogen atom, e.g. bipyridyl, 2-aminopyridine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/32—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen
- C07C1/321—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen the hetero-atom being a non-metal atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/10—Complexes comprising metals of Group I (IA or IB) as the central metal
- B01J2531/16—Copper
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Catalysts (AREA)
Abstract
The present invention relates to double triazole-tetrafluoro boric acid copper complex of anthracene nucleus with catalysis phenyl boric acid and preparation method thereof, disclose one { [Cu (tatrz)2(H2O)2](BF4)2} (1) (tatrz=1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole) preparation method and as catalysis phenyl boric acid coupling reaction there is potential using value.It is to use " normal temperature volatility process ", i.e. Cu (BF4)2Get off to prepare this complex with tatrz stirring at normal temperature volatilization condition.The present invention further discloses { [Cu (tatrz)2(H2O)2](BF4)2} (1) (tatrz=1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole) can be as the application in terms of the coupling reaction catalyst of phenyl boric acid.
Description
The present invention obtains state natural sciences fund general project (21471113), Tianjin Education Commission funded projects
(20140506), Tianjin Normal University's Middl-age and youth faculty Academic innovations advances planning item and Tianjin innovation team of institution of higher education
Training plan subsidizes (TD12-5038).
Technical field
The invention belongs to Inorganic synthese technical field, relate to copper complex { [Cu (tatrz)2(H2O)2](BF4)2} (1)
The preparation method of (tatrz=1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole) and work
For the application in terms of the catalyst of phenyl boric acid coupling reaction.
Background technology
A research always active field of high selectivity is carried out with transition metal complex catalysis.With commonly
Synthesizing mean is difficult to the reaction realized, and busy use transition metal complex can a step complete in a mild condition.Therefore, adopt
Make catalyst with metal complex and develop the organic synthesis of high selectivity, high conversion, be the most interesting
Problem.In organic synthesis, general conventional transition metal has nickel, palladium, copper, ruthenium, rhodium, manganese etc., and wherein palladium complex demonstrates many
Sample catalysis.Palladium catalysed cross coupling reaction kind is a lot, and these reactions are at synthesis of natural product, polymer, functional material, liquid
Crystalline substance, drug molecule and bioactive compound all have been widely used.But palladium catalyst is relatively costly, if can be with cheap
Copper complex replaces expensive palladium catalyst, it is achieved the process of reaction, is possible not only to cost-effective, and is expected to industry metaplasia
Produce.
1,2,4-triazole and derivative thereof have the coordination feature of pyrazoles and imidazoles concurrently, are that the bridging that coordination ability is stronger is joined
Body, has synthesized and has characterized substantial amounts of monokaryon, multinuclear and multidimensional compound the most.These parts can be former with the nitrogen on 1,2
Son forms N1, N2-bridging pattern with metallic ion coordination, can be by 2,4 for 4 unsubstituted 1,2,4-triazole derivatives
On nitrogen-atoms formed N2, N4-bridging pattern, this N2, N4-bridging pattern is with the N1 of imidazoles in metalloenzyme, N3-bridging pattern
Similar.Specific use for triazole class compounds is also manifested by the design of molecular device, and synthesis has different dimension
Metal complex has been the vital step of device.
The present invention is i.e. to select Cu (BF4)2With 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-
Triazole (tatrz) prepares copper complex { [Cu (tatrz) under normal temperature condition2(H2O)2](BF4)2} (1).Catalysis experiments
Proving, this complex can be applied as the catalyst of phenyl boric acid coupling reaction.
Summary of the invention
Offer double triazole-copper complex { [Cu (tatrz) of a kind of anthracene nucleus is provided2(H2O)2]
(BF4)2(1) monocrystalline and preparation method thereof.
Following technical scheme is current inventor provides for this:
Double triazole the copper complex { [Cu (tatrz) of anthracene nucleus2(H2O)2](BF4)2} (1) (tatrz = 1-[9-(1H-1,2,
4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole) and structural motif as shown in Figure 1.
The present invention further discloses double triazole the copper complex { [Cu (tatrz) of anthracene nucleus2(H2O)2](BF4)2} (1)
The monocrystalline of (tatrz=1-[9-(1H-1,2,4-triazole-1-bases) anthracene-10-base]-1H-1,2,4-triazoles), its feature exists
Use APEX II CCD single crystal diffractometer in this mono-crystalline structures, use through graphite monochromatised Mok alpha ray (λ=
0.71073) it is incident radiation, collects point diffraction with ω-2 θ scan mode, obtain structure cell ginseng through least square refinement
Number, utilizes software to solve single crystal data from difference Fourier electron-density map:
The crystallographic data of table 1. complex 1
Double triazole the copper complex { [Cu (tatrz) of anthracene nucleus of the present invention2(H2O)2](BF4)2} (1) (tatrz = 1-
[9-(1H-1,2,4-triazole-1-bases) anthracene-10-base]-1H-1,2,4-triazoles) preparation method of monocrystalline, its feature is at it
To use " normal temperature volatility process ", i.e. Cu (BF4)2Get off to obtain to be suitable for X-ray single crystal diffraction with tatrz stirring at normal temperature volatilization condition
Yellow rhabdolith.Wherein CH3CN and H2The volume ratio of O is 4:6, Cu (BF4)2It is 1:1 with the mol ratio of tatrz；
The more detailed preparation method of the present invention is as follows:
Double triazole the copper complex { [Cu (tatrz) of a kind of anthracene nucleus2(H2O)2](BF4)2} (1) (tatrz = 1-[9-(1H-
1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazoles) preparation method of monocrystalline, its feature " often uses at it
Temperature volatility process ", i.e. Cu (BF4)2Get off to obtain being suitable for the yellow rod of X-ray single crystal diffraction with tatrz stirring at normal temperature volatilization condition
Shape crystal.Wherein CH3CN and H2The volume ratio of O is 4:6, Cu (BF4)2It is 1:1 with the mol ratio of tatrz；
Solvent of the present invention is mixed solvent, CH3CN and H2O。
Wherein Cu (BF4)2It is 1:1 with the mol ratio of tatrz.
The present invention further discloses the double triazole copper complex of a kind of anthracene nucleus and there is the effect of catalysis phenyl boric acid coupling reaction.
Double triazole the copper complex { [Cu (tatrz) of a kind of anthracene nucleus disclosed by the invention2(H2O)2](BF4)2} (1) (tatrz
=1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole) monocrystalline have the advantage that and feature
It is:
(1) operation is simple and easy to do.
(2) reaction yield is high, and the purity of products obtained therefrom is high.
(3) { [Cu (tatrz) prepared by the present invention2(H2O)2](BF4)2} (1) (tatrz = 1-[9-(1H-1,2,
4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazoles) production cost is low, and method is easy, is suitable for large-scale production.
Accompanying drawing explanation
The crystal structure primitive figure of Fig. 1: complex 1；
The tomograph of Fig. 2: complex 1.
The nuclear-magnetism figure of Fig. 3: biphenyl.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, and embodiment is only explanatory, is in no way intended to it
Limit the scope of the present invention by any way.All of raw material is such as: anthracene nucleus etc. are all to enter from chemical reagents corporation both domestic and external
Row is bought, and through continuation purification but does not directly use.Wherein Cu (BF4)2, CH3CN is by commercially available.
Embodiment 1
The preparation of 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole (tatrz) part
The preparation side of 1-of the present invention [9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole
Method, its feature is using " one kettle way ", and in polar solvent, by 9,10-dibromoanthracene, triazole, potassium carbonate and cupric oxide are in heating
Under the conditions of prepare this organic compound；Wherein 9,10-dibromoanthracene: triazole: potassium carbonate: the mol ratio of cupric oxide is 2:10:30:1；
The present invention preferred 9,10-dibromoanthracene (I): triazole (II): potassium carbonate: the mol ratio of cupric oxide is 2:10:30:1；Instead
Answer temperature 80-200 DEG C, 12-120 hour reaction time.
The more detailed preparation method of the present invention is as follows:
A kind of preparation method of 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole its
Being characterised by, in polar solvent, using " one kettle way ", by 9,10-dibromoanthracene, triazole, potassium carbonate and cupric oxide are at fire-bar
This organic compound is prepared under part；
Polar solvent of the present invention is DMF.
Wherein 9,10-dibromoanthracene: triazole: potassium carbonate: the mol ratio of cupric oxide is 2:10-15:30:1；
Embodiment 2
Cu(BF4)2With 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole (tatrz)
Mol ratio be 1:1；
Tatrz (0.0624 g, 0.2 mmol) and Cu (BF4)2(0.0691 g, 0.2 mmol) is at H2O (6 mL)
And CH3In the mixed solvent of CN (4 mL), stirring at normal temperature filtered after half an hour, and filtrate normal temperature volatilization X-ray single crystal diffraction is analyzed
Yellow rhabdolith.Productivity: 35% (calculating based on tatrz).Elementary analysis (C36H28B2CuF8N12O2) theoretical value (%): C,
48.16；H, 3.14；N, 18.72.Measured value: C, 48.15；H, 3.16；N, 18.69.
Embodiment 3
Crystal structure determination uses APEX II CCD single crystal diffractometer, use through graphite monochromatised Mok alpha ray (λ=
0.71073) it is incident radiation, collects point diffraction with ω-2 θ scan mode, obtain structure cell ginseng through least square refinement
Number, utilizes software to solve crystal structure from difference Fourier electron-density map, and through Lorentz lorentz and polarity effect correction.All of
H atom is synthesized by difference Fourier and determines through preferable position calculation.Detailed axonometry data are shown in Table 1.Structural motif is shown in
Fig. 1, the three-dimensional structure of complex is shown in Fig. 2.
The crystallographic data of table 1. complex 1
Embodiment 4
Cu(BF4)2With 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole (tatrz)
Mol ratio be 1:1；
We also attempted other ratios, such as Cu (BF4)2With 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-
Base]-1H-1, the mol ratio of 2,4-triazoles (tatrz) is 2:1, and the most no matter the length of hydro-thermal reaction time, all can not get crystalline state
Compound.Therefore Cu (BF4)2With 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole
(tatrz) mol ratio be 1:1 be optimum response proportioning.
Embodiment 4
A research always active field of high selectivity is carried out with transition metal complex catalysis.With commonly
Synthesizing mean is difficult to the reaction realized, and busy use transition metal complex can a step complete in a mild condition.Therefore, adopt
Make catalyst with metal complex and develop the organic synthesis of high selectivity, high conversion, be the most interesting
Problem.In organic synthesis, general conventional transition metal has nickel, palladium, copper, ruthenium, rhodium, manganese etc., and wherein palladium complex demonstrates many
Sample catalysis.Palladium catalysed cross coupling reaction kind is a lot, and these reactions are at synthesis of natural product, polymer, functional material, liquid
Crystalline substance, drug molecule and bioactive compound all have been widely used.But palladium catalyst is relatively costly, if can be with cheap
Copper complex replaces expensive palladium catalyst, it is achieved the process of reaction, is possible not only to cost-effective, and is expected to industry metaplasia
Produce.
1,2,4-triazole and derivative thereof have the coordination feature of pyrazoles and imidazoles concurrently, are that the bridging that coordination ability is stronger is joined
Body, has synthesized and has characterized substantial amounts of monokaryon, multinuclear and multidimensional compound the most.These parts can be former with the nitrogen on 1,2
Son forms N1, N2-bridging pattern with metallic ion coordination, can be by 2,4 for 4 unsubstituted 1,2,4-triazole derivatives
On nitrogen-atoms formed N2, N4-bridging pattern, this N2, N4-bridging pattern is with the N1 of imidazoles in metalloenzyme, N3-bridging pattern
Similar.Specific use for triazole class compounds is also manifested by the design of molecular device, and synthesis has different dimension
Metal complex has been the vital step of device.
The present invention is i.e. to select Cu (BF4)2With 1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-
Triazole (tatrz) prepares copper complex { [Cu (tatrz) when normal temperature volatilization2(H2O)2](BF4)2} (1).Catalysis
It is demonstrated experimentally that this complex can be applied as the catalyst of phenyl boric acid coupling reaction.
1 g phenyl boric acid, 0.2 g Cs is weighed in 25 mL beakers2CO3, 3 mL DMF and 0.1 g catalyst (complex
1), stirring 1 hour under room temperature, TLC monitoring (PE:EA=1:1) reaction is complete, 10 mLCH2Cl220 mL are used again after extracted products
Distilled water washs, organic phase sewage MgSO4Being dried, filter, precipitation, the thick product obtained strips post with petroleum ether, obtains
Biphenyl.
Claims (2)
1. the double triazole copper complex monocrystalline application in terms of preparing phenyl boric acid coupling reaction catalyst of anthracene nucleus, it is characterised in that should
Mono-crystalline structures uses APEX II CCD single crystal diffractometer, uses through graphite monochromatised Mok alpha ray, λ=0.71073
For incident radiation, collect point diffraction with ω-2 θ scan mode, obtain cell parameter through least square refinement, from difference Fu
Vertical leaf electron-density map utilizes software to solve single crystal data:
The molecular formula of the double triazole copper complex monocrystalline of described anthracene nucleus: [Cu (tatrz)2(H2O)2](BF4)2, wherein tatrz=
1-[9-(1H-1,2,4-triazole-1-base) anthracene-10-base]-1H-1,2,4-triazole.
Application the most according to claim 1, wherein the method for phenyl boric acid coupling reaction is as follows:
1 g phenyl boric acid, 0.2 g Cs is weighed in 25 mL beakers2CO3, the catalyst complexes monocrystalline of 3 mL DMF and 0.1 g,
Stirring 1 hour under room temperature, TLC monitors, 10 mLCH2Cl2Washing with 20 mL distilled water after extracted products, organic phase is with anhydrous again
MgSO4Being dried, filter, precipitation, the thick product obtained strips post with petroleum ether, obtains biphenyl.
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| Title |
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| Aerobic homocoupling of arylboronic acids catalysed by copper terephthalate metal–organic frameworks;Kasi Pitchumani et al.;《Green Chemistry》;20140224;第16卷;第2865-2875页 * |
| Homocoupling of Arylboronic Acids Catalyzed by 1,10-Phenanthroline-Ligated Copper Complexes in Air;N Kirai et al.;《Eur. J. Org. Chem.》;20091231;第12卷;第1864-1867页 * |
| Ju-Yan Liu et al..Anion-Exchange and Anthracene-Encapsulation within Copper(II) and Manganese(II)-Triazole Metal− * |
| Organic Confined Space in a Single Crystal-to-Single Crystal Transformation Fashion.《Inorg. Chem.》.2014,第53卷(第12期),第5972-5985页. * |
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