CN104529975A - Method for extracting 6-methylluteolin from eleocharis tuberose peels - Google Patents
Method for extracting 6-methylluteolin from eleocharis tuberose peels Download PDFInfo
- Publication number
- CN104529975A CN104529975A CN201410833028.3A CN201410833028A CN104529975A CN 104529975 A CN104529975 A CN 104529975A CN 201410833028 A CN201410833028 A CN 201410833028A CN 104529975 A CN104529975 A CN 104529975A
- Authority
- CN
- China
- Prior art keywords
- crude product
- methyl
- extract
- methyl alcohol
- dry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VSHICDFQSGJNPK-UHFFFAOYSA-N 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methylchromen-4-one Chemical compound C=1C(=O)C2=C(O)C(C)=C(O)C=C2OC=1C1=CC=C(O)C(O)=C1 VSHICDFQSGJNPK-UHFFFAOYSA-N 0.000 title claims abstract description 83
- 238000000034 method Methods 0.000 title claims abstract description 13
- 241000202829 Eleocharis Species 0.000 title abstract 4
- 235000016067 Polianthes tuberosa Nutrition 0.000 title abstract 4
- 244000014047 Polianthes tuberosa Species 0.000 title abstract 4
- 239000000284 extract Substances 0.000 claims abstract description 34
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 21
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- 238000005227 gel permeation chromatography Methods 0.000 claims abstract description 9
- 238000000926 separation method Methods 0.000 claims abstract description 9
- 238000004440 column chromatography Methods 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 129
- 239000012043 crude product Substances 0.000 claims description 36
- 235000003283 Pachira macrocarpa Nutrition 0.000 claims description 29
- 235000014364 Trapa natans Nutrition 0.000 claims description 29
- 235000009165 saligot Nutrition 0.000 claims description 29
- 241001083492 Trapa Species 0.000 claims description 26
- 238000000605 extraction Methods 0.000 claims description 22
- 150000001408 amides Chemical class 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 9
- 239000000725 suspension Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 238000000746 purification Methods 0.000 claims description 7
- 239000003480 eluent Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 235000019441 ethanol Nutrition 0.000 claims description 4
- 238000001953 recrystallisation Methods 0.000 claims description 4
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 claims description 3
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 abstract description 5
- 229920002647 polyamide Polymers 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 239000002699 waste material Substances 0.000 abstract description 3
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 description 5
- 240000001085 Trapa natans Species 0.000 description 4
- 238000007654 immersion Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 2
- OKKJLVBELUTLKV-VMNATFBRSA-N methanol-d1 Chemical compound [2H]OC OKKJLVBELUTLKV-VMNATFBRSA-N 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000234646 Cyperaceae Species 0.000 description 1
- 244000103152 Eleocharis tuberosa Species 0.000 description 1
- 235000014309 Eleocharis tuberosa Nutrition 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002659 luteolin Chemical class 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410833028.3A CN104529975B (en) | 2014-12-29 | 2014-12-29 | Corm Eleocharitis skin extracts the method for 6-methyl luteolin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410833028.3A CN104529975B (en) | 2014-12-29 | 2014-12-29 | Corm Eleocharitis skin extracts the method for 6-methyl luteolin |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104529975A true CN104529975A (en) | 2015-04-22 |
CN104529975B CN104529975B (en) | 2016-07-06 |
Family
ID=52845647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410833028.3A Active CN104529975B (en) | 2014-12-29 | 2014-12-29 | Corm Eleocharitis skin extracts the method for 6-methyl luteolin |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104529975B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101269161A (en) * | 2008-05-20 | 2008-09-24 | 贺州学院 | Technique for extracting total flavone from eleocharis dulcis trin.ex henschel husk |
CN103087546A (en) * | 2013-01-18 | 2013-05-08 | 江汉大学 | Method for extracting pigments in eleocharis tuberose peel |
-
2014
- 2014-12-29 CN CN201410833028.3A patent/CN104529975B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101269161A (en) * | 2008-05-20 | 2008-09-24 | 贺州学院 | Technique for extracting total flavone from eleocharis dulcis trin.ex henschel husk |
CN103087546A (en) * | 2013-01-18 | 2013-05-08 | 江汉大学 | Method for extracting pigments in eleocharis tuberose peel |
Also Published As
Publication number | Publication date |
---|---|
CN104529975B (en) | 2016-07-06 |
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PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20150422 Assignee: Guangxi Hengfengda Supply Chain Management Co.,Ltd. Assignor: HEZHOU University Contract record no.: X2023980046610 Denomination of invention: Method for Extracting 6-Methyl Luteolin from Water Chestnut Peel Granted publication date: 20160706 License type: Common License Record date: 20231108 Application publication date: 20150422 Assignee: Pingle Leyao Food Co.,Ltd. Assignor: HEZHOU University Contract record no.: X2023980046448 Denomination of invention: Method for Extracting 6-Methyl Luteolin from Water Chestnut Peel Granted publication date: 20160706 License type: Common License Record date: 20231108 |