CN104523754A - Cod-liver oil drop pill for promoting infant development - Google Patents
Cod-liver oil drop pill for promoting infant development Download PDFInfo
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- CN104523754A CN104523754A CN201410801526.XA CN201410801526A CN104523754A CN 104523754 A CN104523754 A CN 104523754A CN 201410801526 A CN201410801526 A CN 201410801526A CN 104523754 A CN104523754 A CN 104523754A
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Abstract
The invention discloses a cod-liver oil drop pill for promoting infant development. The cod-liver oil drop pill consists of a drop pill body and content packaged in the drop pill body, wherein the drop pill body is formed by mixing gelatin, glycerol and water in a conventional proportion. The cod-liver oil drop pill is characterized in that the content consists of the following components in percentage by weight: 40-60% of cod-liver oil, 20-40% of walnut oil, 10-30% of algae oil DHA (docosahexaenoic acid), and 0.06-0.1% of natural vitamin E. The cod-liver oil drop pill is simple in material composition, scientific in formula, proper in proportioning, good in digestive absorption, and convenient to take; the components generate a synergistic effect to achieve effects of promoting infant brain development, retinal development, and the like; meanwhile, the cold-liver oil drop pill is beneficial to balancing metabolism and promoting the infant nervous system and skeletal development.
Description
Technical field
The present invention relates to the dietetic product changing food nutrition character, especially a kind of cod-liver oil drop pill promoting infant development.
Background technology
Drop pill, after solid or liquid medicine and substrate mix heat fused, instills in not miscible liquid coolant, shrinks a kind of quick-effective preparation being condensed into ball.Its principal agent is mainly dispersed in substrate in colloid, molecule or microcrystalline state, and medicine total surface area is increased, thus dissolution rate is accelerated, and absorb completely, bioavailability is high, and dosage is accurate, and medicine stability is high, not facile hydrolysis, oxidation.
At present, have been reported about the health food containing cod liver oil, such as, disclosed in the CN103284153A Chinese invention patent application description that JIUYUE in 2013 was applied for by By-Health Co., Ltd. disclosed in 11 days " cod liver oil soft capsule and preparation method thereof ", its content is cod liver oil 450 ~ 540g, natural Vitamin E 0.45 ~ 0.55g, its dosage form is soft capsule, and this soft capsule dosage form exists the shortcomings such as onset is slow, gastrointestinal reaction.
Summary of the invention
In order to overcome, onset in prior art is slow, the deficiency of gastrointestinal reaction, the invention provides the cod-liver oil drop pill of promotion infant development that a kind of scientific formula, proportioning are appropriate, digest and assimilate.
The technical solution adopted for the present invention to solve the technical problems is: a kind of cod-liver oil drop pill promoting infant development, it is made up of drop pill body and the content be encapsulated in this drop pill body, described drop pill body be by gelatin, glycerol, water routinely ratio make, it is characterized in that: described content is made up of the component of following weight percents: cod liver oil 40 ~ 60%, walnut oil 20 ~ 40%, algae oil DHA10 ~ 30%, natural Vitamin E 0.06 ~ 0.1%, the percentage by weight sum of each component is 100%.
The preferred technical solution of the present invention is: the percentage by weight of described component is respectively: cod liver oil 50%, walnut oil 30%, algae oil DHA19.92%, natural Vitamin E 0.08%.
Cod-liver oil drop pill of the present invention can be passed through the preparation of glue, content preparation, pill, whole ball, drying, wash the operations such as ball and make, produce the cod-liver oil drop pill that content content is 300mg ~ 600mg/ ball.Its drop pill body is made up in the ratio of 100:100:40 of gelatin, glycerol, water.The concrete preparation technology of cod-liver oil drop pill of the present invention is same as the prior art, repeats no more.
Usage of the present invention and consumption are: every day, recommended amounts was 1g.Be every day 2 times by human body recommended intake, each 1, can long-term taking.
In the present invention, each component effect is as follows: the liver oil content of morrhua is up to 40%, and cod liver oil, except being rich in all vitamin A of common cod-liver oil, outside vitamin D, also contains human brain, eye development necessary DHA, DPA, ARA.Cod liver oil becomes the superfine product in cod-liver oil, is described as " liquid golden "; Walnut oil is that the Semen Juglandis choosing high-quality does waste natural fruit oil juice out, and its taste fresh is pure, nutritious, mouthfeel is light, and fatty acid configuration is similar to breast milk, easy digested absorption, is the high-class healthy edible oil of childhood development phase.Its nutrient content: unsaturated fatty acid content >=92%, linoleic acid Ω-6 >=56%, linolenic acid Ω-3 >=14%, be rich in the nutrient substance such as natural VA, VD, acidity≤0.5, the light free from extraneous odour of mouthfeel, and pure raw original flavor is particularly suitable for the tender and lovely stomach of baby; Algae can by self fermentation synthesis DHA, and therefore algae DHA content is high, and EPA content is extremely low, and the ratio extracting DHA and EPA from algae is 20:1, and the DHA that algae is extracted is pure natural, vegetal, oxidation resistance is strong, EPA content is few; The DHA that algal oil extracts is conducive to the absorption of child most, and effectively can promote the growth of baby's retina and brain; Vitamin E is also known as vitamin e; it is a kind of fatsoluble vitamin having 8 kinds of forms; it is an important antioxidant; easily oxidized material can be protected in vivo; reduce over the generation of lipid oxide; the protein active structure of energy stabilizing cell membrane, promotes the normal development of muscle and keeps the elasticity of skin, making skin and health maintain vigour.In the cod-liver oil drop pill of promotion infant development of the present invention, cod liver oil strand is little, in addition walnut oil acidity≤0.5, the light free from extraneous odour of mouthfeel, and pure raw original flavor is particularly suitable for the tender and lovely the intestines and stomach of baby; The interpolation of algae oil DHA simultaneously adds the ratio of DHA and EPA in product, more meets child's recommended amounts, there will not be the problem of excessive amount.Organic cold pressing walnut oil, containing natural value physical property vitamin A, D composition, by the interpolation recommending amount can reduce cod-liver oil, while cost-saving, also can reduce the fishlike smell of cod liver oil, easily be accepted by child the sense of taste.The interpolation of vitamin E can with the synergism such as the polyphenolic substance in walnut oil, chromocor compound, have very strong non-oxidizability, in protection raw material, the unsaturated fatty acid of high-load is not oxidized, ensure that the biological activity of product.Drops of the present invention has stronger protection to content, not only Orally-administrable but also can sublingual administration, be comprehensive stability good, be easy to that storage carries, taking convenience, untoward reaction are few, Modern New preparation safely and efficiently.Raw material of the present invention composition is simple, scientific formula, proportioning are appropriate, digest and assimilate, and has and promotes infant brain development, the effects such as retinal development, contribute to balancing metabolism simultaneously, promote nervous system in children, skeleton development.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Raw materials usedly in the present embodiment be commercial products, wherein,
Cod liver oil is purchased from the holy promise of Norway, and content is VA2500IU/g, VD250IU/g.The liver oil content of this morrhua is up to 40%, and cod liver oil, except being rich in all vitamin A of common cod-liver oil, outside vitamin D, also contains human brain, eye development necessary DHA, DPA, ARA.Cod liver oil becomes the superfine product in cod-liver oil, is described as " liquid golden ".
Walnut oil is purchased from Handan morning twilight, and LA content is 50%-69%.This walnut oil taste fresh is pure, nutritious, mouthfeel is light, and fatty acid configuration is similar to breast milk, easy digested absorption, is the high-class healthy edible oil of childhood development phase.Its nutrient content: unsaturated fatty acid content >=92%, linoleic acid Ω-6 >=56%, linolenic acid Ω-3 >=14%, be rich in the nutrient substance such as natural VA, VD, acidity≤0.5, the light free from extraneous odour of mouthfeel, and pure raw original flavor is particularly suitable for the tender and lovely stomach of baby.
DHA is healthy and free from worry purchased from riverhead for algae oil, and DHA content is 45%.The DHA of this algae oil is pure natural, vegetal, oxidation resistance is strong, EPA content is few; The ratio of DHA and EPA is 20:1, is conducive to the absorption of child most, and effectively can promote the growth of baby's retina and brain.
Natural Vitamin E is fragrant purchased from her treasured of Zhejiang, and VE content is 1000IU/g.This vitamin E is a kind of fatsoluble vitamin having 8 kinds of forms; it is an important antioxidant; easily oxidized material can be protected in vivo; reduce over the generation of lipid oxide; the protein active structure of energy stabilizing cell membrane; promote the normal development of muscle and keep the elasticity of skin, making skin and health maintain vigour.
In the cod-liver oil drop pill of promotion infant development of the present invention, cod liver oil strand is little, in addition walnut oil acidity≤0.5, the light free from extraneous odour of mouthfeel, and pure raw original flavor is particularly suitable for the tender and lovely the intestines and stomach of baby; The interpolation of algae oil DHA simultaneously adds the ratio of DHA and EPA in product, more meets child's recommended amounts, there will not be the problem of excessive amount.Organic cold pressing walnut oil, containing natural value physical property vitamin A, D composition, by the interpolation recommending amount can reduce cod-liver oil, while cost-saving, also can reduce the fishlike smell of cod liver oil, easily be accepted by child the sense of taste.The interpolation of vitamin E can with the synergism such as the polyphenolic substance in walnut oil, chromocor compound, have very strong non-oxidizability, in protection raw material, the unsaturated fatty acid of high-load is not oxidized, ensure that the biological activity of product.Drops of the present invention has stronger protection to content, not only Orally-administrable but also can sublingual administration, be comprehensive stability good, be easy to that storage carries, taking convenience, untoward reaction are few, Modern New preparation safely and efficiently.
embodiment 1
A kind of cod-liver oil drop pill promoting infant development, it is made up of drop pill body and the content be encapsulated in this drop pill body, drop pill body is made up in the ratio of 100:100:40 of gelatin, glycerol, water, its content is made up of the component of following weight percents: cod liver oil 50%, walnut oil 30%, algae oil DHA19.92%, natural Vitamin E 0.08%.The cod-liver oil drop pill raw material composition of the promotion infant development that the present embodiment provides is simple, scientific formula, and proportioning is appropriate, digests and assimilates, taking convenience, has and promotes infant brain development, the effects such as retinal development.
embodiment 2
A kind of cod-liver oil drop pill promoting infant development, it is made up of drop pill body and the content be encapsulated in this drop pill body, drop pill body is made up in the ratio of 100:100:40 of gelatin, glycerol, water, and its content is made up of the component of following weight percents: cod liver oil 40%, walnut oil 40%, algae oil DHA19.9%, natural Vitamin E 0.1%.The cod-liver oil drop pill raw material composition of the promotion infant development that the present embodiment provides is simple, scientific formula, and proportioning is appropriate, digests and assimilates, taking convenience, has and promotes infant brain development, the effects such as retinal development.
embodiment 3
A kind of cod-liver oil drop pill promoting infant development, it is made up of drop pill body and the content be encapsulated in this drop pill body, drop pill body is made up in the ratio of 100:100:40 of gelatin, glycerol, water, and its content is made up of the component of following weight percents: cod liver oil 60%, walnut oil 29.94%, algae oil DHA10%, natural Vitamin E 0.06%.The cod-liver oil drop pill raw material composition of the promotion infant development that the present embodiment provides is simple, scientific formula, and proportioning is appropriate, digests and assimilates, taking convenience, has and promotes infant brain development, the effects such as retinal development.
embodiment 4
A kind of cod-liver oil drop pill promoting infant development, it is made up of drop pill body and the content be encapsulated in this drop pill body, drop pill body is made up in the ratio of 100:100:40 of gelatin, glycerol, water, and its content is made up of the component of following weight percents: cod liver oil 49.9%, walnut oil 20%, algae oil DHA30%, natural Vitamin E 0.1%.The cod-liver oil drop pill raw material composition of the promotion infant development that the present embodiment provides is simple, scientific formula, and proportioning is appropriate, digests and assimilates, taking convenience, has and promotes infant brain development, the effects such as retinal development.
In embodiment of the present invention 1-4, involved product is all be prepared from according to following process steps:
1) preparation of glue: get gelatin and add suitable quantity of water and make it expand; Another glycerol and water being put in glue pot is heated to 70 ~ 80 DEG C, mix homogeneously, and the gelatin adding expansion stirs, and fusing, is incubated 1 ~ 2 hour, leaves standstill, foam is floated, and the foam that removing is floated filters with clean calico, insulation, for subsequent use;
2) preparation of content: take cod liver oil, walnut oil, algae oil DHA, natural Vitamin E mixing by proportioning, fully stir evenly, for subsequent use;
3) pill: by step 1) glue for preparing, step 2) content for preparing respectively splendid attire in hopper, by dripping machine shower nozzle, two liquid are sprayed by concentric tube by friction speed, glue flows out from the skin of pipe, content flows out from central canal, in the exit of concentric tube, a certain amount of content is wrapped up by glue, and be added dropwise in another kind of not miscible liquid coolant, after glue contact cooling liquid, formation is made it spherical due to surface tension effects, and solidify gradually and form drop pill, wherein, the temperature of glue and content controls at about 60 DEG C, it is 10 ~ 17 DEG C that coolant temperature controls, room temperature 10 ~ 20 DEG C, water dropper temperature 40 ~ 50 DEG C,
4) whole ball: by step 3) first evenly stall with goods spread out on the ground for sale is on gauze for the drop pill that oozes, and below 10 DEG C, low temperature is dried more than 4 hours, then wipes the liquid coolant on surface with pill wiping machine;
5) dry with wash ball: by step 4) drop pill 95% ethanol of wiping surface cool liquid washes away the surperficial oil reservoir of drop pill, then dries up washing liquid, in 40 ~ 50 DEG C of dryings about 24 hours; Take out dry drop pill, lamp inspection, after the useless ball of removing, use 95% washing with alcohol, then dry up at 40 ~ 50 DEG C, pack, finished product.
the cod-liver oil drop pill of the promotion infant development provided with embodiment 1 below carries out zoopery, further illustrates fish oil drop pill of the present invention and mainly has the effect promoting brain development.
1), experiment material
Be sample by the cod-liver oil drop pill given by embodiment 1.The firm male mouse of kunming 80 from breast, body weight 10 ~ 11g.
2), animal experiment
Mice is divided into four groups at random, and often organize each 20 mices, wherein experimental group three components is not labeled as A, B, C group, and matched group one group echo is D group, carries out feed material respectively to these four groups of mices.
A group: one group of mice in the cod-liver oil drop pill sample provided with embodiment 1 and the random feed experimental group of normal diet stirring and evenly mixing;
B group: the DHA of DHA equivalent contained in the cod-liver oil drop pill sample provided with embodiment 1 is converted to a certain amount of algae oil, with arbitrary group of mice in the random feed experimental group of normal diet stirring and evenly mixing;
C group: the ALA of ALA equivalent contained in the cod-liver oil drop pill sample provided with embodiment 1 is converted to a certain amount of walnut oil, remains one group of mice with normal diet stirring and evenly mixing feed experimental group;
D group: only using the normal diet feeding mice of equivalent as blank.
After mice feeds 40 days, Jumping test (experimental result is in table 1) and water maze laboratory (experimental result is in table 2) are carried out respectively to each group of mice.
table 1 Jumping test result
| Group | Incubation period | Error number |
| A group | 151.1±10.56 | 0.72±0.23 |
| B group | 138.6±14.2 | 1.01±0.32 |
| C group | 119.8±14.3 | 1.25±0.25 |
| D group | 104.6±14.46 | 1.45±0.34 |
table 2 maze experiment result
| Group | Walk the labyrinth time | Error number |
| A group | 30.72±5.98 | 2.38±0.32 |
| B group | 41.05±7.23 | 3.45±0.58 |
| C group | 58.86±8.48 | 4.03±0.72 |
| D group | 68.25±6.55 | 4.68±0.55 |
Table 1 data show, diving tower comparatively control group mice prolongation incubation period of three groups of experimental mice, error number comparatively control group mice minimizing, the longest with A group mice diving tower incubation period (151.1 ± 10.56) in three groups of experimental grouies, be longer than B group and C group mice diving tower incubation period, especially be obviously longer than and D group mice diving tower incubation period, difference has significance (P < 0.05).
Table 2 data show, three groups of experimental mice comparatively control group mice are walked the labyrinth time (68.25 ± 6.55) and are all shortened, wherein the A group rat/mouse labyrinth time is 30.72 ± 5.98, comparatively there is remarkable shortening the D group rat/mouse labyrinth time, difference has significance (P < 0.05), and error number also significantly reduces (P < 0.05).Above result shows that DHA and ALA has certain promotion to developing mice spatial discrimination learning and memory, but A group feedstuff compared with the B group feedstuff of equivalent or the facilitation of C group feedstuff to developing mice spatial discrimination learning and memory of equivalent more remarkable.
As can be seen here, cod-liver oil drop pill of the present invention has the effect promoting brain development.
Claims (2)
1. one kind promotes the cod-liver oil drop pill of infant development, it is made up of drop pill body and the content be encapsulated in this drop pill body, described drop pill body be by gelatin, glycerol, water routinely ratio mix, it is characterized in that: described content is made up of the component of following weight percents: cod liver oil 40 ~ 60%, walnut oil 20 ~ 40%, algae oil DHA10 ~ 30%, natural Vitamin E 0.06 ~ 0.1%, the percentage by weight sum of each component is 100%.
2. a kind of cod-liver oil drop pill promoting infant development according to claim 1, is characterized in that: the percentage by weight of described component is respectively: cod liver oil 50%, walnut oil 30%, algae oil DHA19.92%, natural Vitamin E 0.08%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259235A (en) * | 2018-08-31 | 2019-01-25 | 安徽济生元药业有限公司 | A kind of improvement eyesight promotes brain development cod liver oil soft capsule |
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| CN101028335A (en) * | 2006-02-28 | 2007-09-05 | 上海水产大学 | Walnut oil health-care soft capsule |
| CN101336902A (en) * | 2008-08-12 | 2009-01-07 | 西安交通大学 | Liposomes sodium morrhuate |
| CN103284153A (en) * | 2013-06-18 | 2013-09-11 | 汤臣倍健股份有限公司 | Cod liver oil soft capsule and preparation method thereof |
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2014
- 2014-12-22 CN CN201410801526.XA patent/CN104523754A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101028335A (en) * | 2006-02-28 | 2007-09-05 | 上海水产大学 | Walnut oil health-care soft capsule |
| CN101023963A (en) * | 2007-03-28 | 2007-08-29 | 汪昔奇 | Method for preparing natural astaxanthin and fishliver oil |
| CN101336902A (en) * | 2008-08-12 | 2009-01-07 | 西安交通大学 | Liposomes sodium morrhuate |
| CN103284153A (en) * | 2013-06-18 | 2013-09-11 | 汤臣倍健股份有限公司 | Cod liver oil soft capsule and preparation method thereof |
Non-Patent Citations (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109259235A (en) * | 2018-08-31 | 2019-01-25 | 安徽济生元药业有限公司 | A kind of improvement eyesight promotes brain development cod liver oil soft capsule |
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Application publication date: 20150422 |