CN104523609A - Mongolian-medicine pill dosage form - Google Patents
Mongolian-medicine pill dosage form Download PDFInfo
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- CN104523609A CN104523609A CN201410693830.7A CN201410693830A CN104523609A CN 104523609 A CN104523609 A CN 104523609A CN 201410693830 A CN201410693830 A CN 201410693830A CN 104523609 A CN104523609 A CN 104523609A
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- nucleocapsid
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- core shell
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Abstract
A disclosed Mongolian-medicine pill dosage form is composed of a master batch, a first-order core shell and a second-order core shell; the master batch is disposed at the innermost layer, the exterior of the master batch is provided with the first-order core shell, and the exterior of the first-order core shell is provided with the second-order core shell; the master batch is prepared by performing low-temperature superfine crushing on a volatile material and performing combination; the first-order core shell is formed by crushing a part of medicinal materials and performing core shell combination and vibration forming through the vibration extrusion effect of a vibration medium for completely uniformly coating the periphery of the master batch; and the second-order core shell is formed by crushing residual medicinal materials with stable compositions and relatively good color and smell, and performing core shell combination and vibration forming through the extrusion effect of a vibration medium for completely uniformly coating the periphery of the first-order core shell. By employing the formed three-layer one-body composite particle structure, the precise particle compound with the three-layer one-body structure is capable of covering stink odor of Chinese and Mongolian medicines and avoiding loss of volatile compositions, has consistent smell and color, and has moistureproof performance, and the homogeneity of medicines is furthest guaranteed.
Description
Technical field
The present invention relates to mongolian medicine preparation field, be specifically related to a kind of mongolian medicine pill dosage form construct.
Background technology
The pill of traditional mongolian medicine is all the mixture of uniform component, but determines the quality problems such as middle mongolian medicine pill disperses is uneven, composition scatters and disappears, stripping is unreasonable, curative effect is unstable, toxicity due to the complexity of composition.
RouKouWuWei Pill medicinal ingredient and ratio as follows: Semen Myristicae 100 grams, Radix Inulae 80 grams, the Radix Aucklandiae 80 grams, Fructus Choerospondiatis 50 grams, Fructus Piperis Longi 10 grams.There is the heart of dispelling " conspicuous according to " sick.For vexed insomnia, irritability.
The party's contained drug can be divided into by dissolubility:
Water solublity active ingredient: gallic acid, 3,3 ＇-dimethoxy ellagic acid, cupreol, octadecanol, triacontanol, octacosane, salicylic acid etc. in Fructus Choerospondiatis;
Fat-soluble active ingredient: the volatile oil component such as nopinene, γ-terpinene, methyleugenol, myristic acid in Semen Myristicae; The volatile oil such as alantolactone, isoalantolactone in Radix Inulae; Note class in the Radix Aucklandiae; Distylin, Quercetin, protocatechualdehyde, daucosterol, alcohol, phthalic acid two (2-second-base) ester in Fructus Choerospondiatis; Alkaloid, amine, volatilization wet goods in Fructus Piperis Longi;
Wherein in Fructus Piperis Longi, Semen Myristicae, Radix Inulae, volatile oil component is volatile scatters and disappears, unstable.
Drug powder character:
The Radix Aucklandiae, Semen Myristicae matter are solid, mealiness; Radix Inulae matter is hard, not frangibility, mealiness; Fructus Choerospondiatis sarcocarp is thin, sepia, and matter is hard and crisp; Fructus Piperis Longi matter is hard and crisp, frangibility, and section is irregular, graininess.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, and a kind of mongolian medicine pill dosage form construct is provided, according to prescription drug dissolubility and dissolution, stability, pharmacodynamics, toxicology and the aspect information such as clinical practice and drug powder character are foundation, adopt solid dispersal, enclose, the general system of multilamellar, extrude-multiple the forming technique such as round as a ball, carry out matrix type, multilayer coating structure type, pellet form structural design and the preparations such as coated-skeleton conjunction type, make the balanced stripping of each composition energy in prescription, toxic component stable sustained-release, improve the stability of volatile ingredient, mask the bad smell of middle mongolian medicine, structure and pharmaceutical properties and clinical demand reach Optimum Matching, pill is made to reach safe and effective, compliance is good, stablize controlled prescription.
Technical scheme of the present invention is as follows:
A kind of mongolian medicine pill dosage form construct, by coatingparticles, one-level nucleocapsid and secondary nucleocapsid composition, coatingparticles is positioned at innermost layer, coatingparticles is outward one-level nucleocapsid, one-level nucleocapsid is outward secondary nucleocapsid, wherein coatingparticles is composited after superfine comminution at low temperature by volatile material, for the core of whole particle, one-level nucleocapsid is that part medical material is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around coatingparticles and formed, secondary nucleocapsid is that residual components is stablized, the good medical material of color and luster abnormal smells from the patient is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around one-level nucleocapsid and formed.
RouKouWuWei Pill dosage form construct, by coatingparticles, one-level nucleocapsid and secondary nucleocapsid composition, coatingparticles is positioned at innermost layer, coatingparticles is outward one-level nucleocapsid, one-level nucleocapsid is outward secondary nucleocapsid, wherein coatingparticles is by containing the Radix Inulae least stablizing volatile ingredient, the Radix Aucklandiae is composited, for the core of whole particle, one-level nucleocapsid is Fructus Piperis Longi, Semen Myristicae is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around coatingparticles and formed, secondary nucleocapsid is that Fructus Choerospondiatis is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around one-level nucleocapsid and formed.
The invention has the advantages that:
" three layers of one " composite particle structures molding, with the medical material containing effumability composition for coatingparticles, using part medical material as one-level nucleocapsid, using stable components, the good middle mongolian medicine material of color and luster abnormal smells from the patient as secondary nucleocapsid, together constitute can cover middle mongolian medicine bad smell, avoid the scattering and disappearing of volatile ingredient, abnormal smells from the patient color and luster is consistent, have the accurate particle composite of three layers of one of humidity resistance, this compound particle is as minimum drug delivery unit, farthest ensure that the homogeneity of medicine, improve the character of preparation.
Description of drawings 1 is overall structure schematic diagram of the present invention.
The invention will be further described below in conjunction with accompanying drawing for detailed description of the invention.
A kind of mongolian medicine pill dosage form construct, by coatingparticles 1, one-level nucleocapsid 2 and secondary nucleocapsid 3 form, coatingparticles 1 is positioned at innermost layer, coatingparticles 1 is outer is one-level nucleocapsid 2, one-level nucleocapsid 2 is outer is secondary nucleocapsid 3, wherein coatingparticles 1 is composited after superfine comminution at low temperature by volatile material, for the core of whole particle, one-level nucleocapsid 2 is that part medical material is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around coatingparticles and formed, secondary nucleocapsid 3 is that residual components is stablized, the good medical material of color and luster abnormal smells from the patient is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around one-level nucleocapsid and formed.
RouKouWuWei Pill dosage form construct, by coatingparticles 1, one-level nucleocapsid 2 and secondary nucleocapsid 3 form, coatingparticles 1 is positioned at innermost layer, coatingparticles 1 is outer is one-level nucleocapsid 2, one-level nucleocapsid 2 is outer is secondary nucleocapsid 3, wherein coatingparticles 1 is by containing the Radix Inulae least stablizing volatile ingredient, the Radix Aucklandiae is composited, for the core of whole particle, one-level nucleocapsid 2 is Fructus Piperis Longi, Semen Myristicae is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around coatingparticles and formed, secondary nucleocapsid 3 is that Fructus Choerospondiatis is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around one-level nucleocapsid and formed.
RouKouWuWei Pill dosage form construct processing method of the present invention is as follows:
1. coatingparticles Study on Preparation
A. coatingparticles structure of modification: Radix Inulae, the Radix Aucklandiae adopt particle design technology, are prepared into dispersed compound particle;
B. the Study on Preparation of coatingparticles: with the new compound particle after structure of modification for raw material, adopt the general method for making of coating pan, with roundness, particle size distribution, hardness, dissolution etc. for evaluation index, main to rotating speed, add powder speed, the technological parameter such as wetting agent sprays into speed, pathogenic wind-warm, wind speed investigates, suitably add a small amount of adjuvant if desired, to improve ball core performance;
2. outer pharmaceutical pack coating process research
A. outer drug particle structure of modification: Fructus Piperis Longi, Semen Myristicae adopt particle design technology to be prepared into both homodisperse compound particles formation one-level core-shell particles, and Fructus Choerospondiatis medicated powder adopts particle design technology to be prepared into secondary core-shell particles;
B. outer pharmaceutical pack coating process research: with the particle after structure of modification for raw material, still adopt the general method for making of coating pan, with roundness, particle size distribution, hardness, dissolution etc. for evaluation index, to rotating speed, add powder speed, the technological parameter such as wetting agent sprays into speed, pathogenic wind-warm, wind speed investigates, suitably add a small amount of adjuvant if desired, to improve pill behavior.
Claims (2)
1. a mongolian medicine pill dosage form construct, it is characterized in that, by coatingparticles (1), one-level nucleocapsid (2) and secondary nucleocapsid (3) composition, coatingparticles (1) is positioned at innermost layer, coatingparticles (1) is outward one-level nucleocapsid (2), one-level nucleocapsid (2) is outward secondary nucleocapsid (3), wherein coatingparticles (1) is composited after superfine comminution at low temperature by volatile material, for the core of whole particle, one-level nucleocapsid (2) is that part medical material is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around coatingparticles and formed, secondary nucleocapsid (3) is that residual components is stablized, the good medical material of color and luster abnormal smells from the patient is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around one-level nucleocapsid and formed.
2. RouKouWuWei Pill dosage form construct, it is characterized in that, by coatingparticles (1), one-level nucleocapsid (2) and secondary nucleocapsid (3) composition, coatingparticles (1) is positioned at innermost layer, coatingparticles (1) is outward one-level nucleocapsid (2), one-level nucleocapsid (2) is outward secondary nucleocapsid (3), wherein coatingparticles (1) is by containing the Radix Inulae least stablizing volatile ingredient, the Radix Aucklandiae is composited, for the core of whole particle, one-level nucleocapsid (2) is Fructus Piperis Longi, Semen Myristicae is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around coatingparticles and formed, secondary nucleocapsid (3) is that Fructus Choerospondiatis is after crushed by the effect of vibration medium squeeze, carry out nucleocapsid compound, vibration moulding, completely evenly be coated on around one-level nucleocapsid and formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410693830.7A CN104523609A (en) | 2014-11-27 | 2014-11-27 | Mongolian-medicine pill dosage form |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410693830.7A CN104523609A (en) | 2014-11-27 | 2014-11-27 | Mongolian-medicine pill dosage form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104523609A true CN104523609A (en) | 2015-04-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410693830.7A Pending CN104523609A (en) | 2014-11-27 | 2014-11-27 | Mongolian-medicine pill dosage form |
Country Status (1)
| Country | Link |
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| CN (1) | CN104523609A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861131A (en) * | 2005-05-13 | 2006-11-15 | 康国忠 | Qingkailing dixinwan pill prepn. and its prepn. method |
| CN102526124A (en) * | 2011-01-31 | 2012-07-04 | 成都科尔医药技术有限公司 | Traditional Chinese medicinal powder and preparation method thereof |
-
2014
- 2014-11-27 CN CN201410693830.7A patent/CN104523609A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1861131A (en) * | 2005-05-13 | 2006-11-15 | 康国忠 | Qingkailing dixinwan pill prepn. and its prepn. method |
| CN102526124A (en) * | 2011-01-31 | 2012-07-04 | 成都科尔医药技术有限公司 | Traditional Chinese medicinal powder and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 韩丽等: "适宜中药特性的粉体改性技术方法研究", 《中草药》 * |
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Application publication date: 20150422 |
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