CN104523229A - Image acquisition system for breast cancer diagnosis equipment - Google Patents
Image acquisition system for breast cancer diagnosis equipment Download PDFInfo
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- CN104523229A CN104523229A CN201410828085.2A CN201410828085A CN104523229A CN 104523229 A CN104523229 A CN 104523229A CN 201410828085 A CN201410828085 A CN 201410828085A CN 104523229 A CN104523229 A CN 104523229A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/70—Means for positioning the patient in relation to the detecting, measuring or recording means
- A61B5/708—Breast positioning means
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Abstract
The invention discloses an image acquisition system for a breast cancer diagnosis equipment. The image acquisition system for the breast cancer diagnosis equipment comprises a mounting rack, an LED light source which is arranged on the mounting rack and used for producing infrared light, and an image acquisition module which is arranged on the mounting rack and at the upper portion of the LED light source and is used for receiving the infrared light which is emitted by the LED light source and penetrates the examined breast; the image acquisition module comprises a CCD vidicon used for shooting dynamic images and an air bag used for compressing the breast. Uniform distributed pressure can be exerted on the breast by the image acquisition module through the air bag, so that the blood content and the deoxygenated hemoglobin can be driven to produce obvious changes, and therefore mammary gland malignant lesion characteristics detected by adopting the two features of the blood content and the deoxygenated hemoglobin is 6-8 years earlier than that detected by the traditional imaging methods.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of special equipment for diagnosing mammary cancer.
Background technology
In scientific and technological circle, the process of new vascular generation has proved has direct association with the advolution of most of cancer, and it also has close ties with other more than 70 kinds of human diseasess simultaneously.
New vascular generation is the key organism process occurred in health tissues and diseased tissue.Under normal circumstances, new vascular generation is necessary for regeneration, fetal development and wound repair.In these cases, complicated neo-angiogenesis process maintains delicate balance.This balance is completed by the multiple new vascular generation stimulating growth factor, cardiovascular inhibitor, cell aggregation molecule, extracellular matrix and other regulatory factor combineds effect.But, new vessels too much or very little will be produced when this balance is destroyed, thus cause different pathological states, as cancer, rheumatic arthritis and coronary artery disease etc.As all cells, the tumor cell at initial stage needs the supply of continuously nutrient and oxygen, and waste elimination.Tumor, when very little state (about diameter about 1mm), is just enough to provide nutrient and excrete wastes by cell membrane.When diameter of tumor growth is more than 1mm, tumor cell just as the health tissues around it, must generate their blood supply system.Tumor be formed with a progressive process, be that cell repeatedly gene mutation occurs and the result of accumulation.Along with these abnormal sudden changes accumulate, by quantitative change to qualitative change, cell obtains the characteristic of malignant cell gradually, the fertility namely strengthened, the property invaded transfer ability etc.Mammary neoplasms development and new vascular generation relation as shown in Figure 5.Do not invade surrounding tissue at carcinoma, before metastasis, use topical therapeutic means, coordinate whole body therapeutic, great majority (more than 90%) carcinoma can be made to be effected a radical cure.
Significant optical contrast's mechanism that the low Optical Absorption Characteristics relatively uniform due to mammary gland tissue and cancerous issue angiogenic effect provide, as hemoglobin concentration rising and blood oxygen saturation reduction etc., optical breast chromatographic technique is in sensitivity, the aspect such as specificity and safety comparatively X-ray, magnetic resonance and traditional anatomy imaging mode such as ultrasonic have potential comprehensive advantage. and existing various optical diagnostic method is mostly only to optics or the fluorescent characteristic imaging of organizer: as blood oxygen diffuse optical chromatography can principle obtain for differentiating the intrinsic physiological feature organizing good evil degree, but due to the serious pathosis of its inverse problem and rely on the finiteness of endogenous contrast, there is precision deficiency in the method and pseudomorphism disturbs large shortcoming in actual applications, exogenous contrast strengthen (2 ~ 4 times) mechanism that the significant difference that fluorescence diffused light chromatography relies on fluorescent agent pharmacokinetics performance between pathological changes and normal structure provides, can more reliably obtain knub position information, but the intrinsic physiological feature of organizer cannot be obtained.
Closely knit capillary network is shot through with in normal cell tissue.Blood capillary is made up of endotheliocyte, is responsible for supply nutrient, discharges refuse.When cell hypoxia, cell tissue will discharge neovascularity somatomedin, such as VEGF (VEGF) and basic fibroblast growth factor (bFGF), stimulates vascular endothelial cell breed and form new blood capillary.Some tumor cell, also as normal cell, has the ability of secretion neovascularity somatomedin, thus can attract endotheliocyte from adjacent tissue, and cause endothelial cell proliferation.By impelling the growth of blood capillary in tumor, tumor cell can directly obtain containing enriching nutrient and the development of oxygen confession growth of tumour cell from blood, and being transferred out its excrete wastes by neovasculature, tumor cell also therefore ramp simultaneously extensive diffusive.Whether doctor can exist by observing tumor specimen the stage of development that compactness capillary network judges tumor, and predicts the evolution in its future.The neo-angiogenesis process of tumor is as follows:
(i) starting stage: pathological tissues (tumor) generates and release new angiogenesis factor, and is diffused in the tissue of surrounding by these somatomedin.
(ii) vascular endothelial cell proliferation and the stage of intrusion: neovascularity somatomedin is attached on the sensor of neighbouring vascular endothelial cell.Inner at vascular endothelial cell, signal sends from cell surface to nucleus, and cell starts to produce new molecule, comprises enzyme.The cellular matrix of the shell sample around blood vessel is dissolved a duck eye by enzyme.Vascular endothelial cell starts schizogamy, and by solution cavity to the growth migration of tumor direction.Be called the particular molecule of adhesion molecule or cellular integration element (α v β 3 and α v β 5), help stretching vascular bud forward most advanced and sophisticated.One is called matrix metalloproteinase, can dissolve the tissue sprouting blood vessel front end, along with the expansion of blood vessel, organize the shape be just transformed into around blood vessel.The vascular endothelial cell sprouted is around formation vascular canal, and each vascular canal couples together and forms complete vascular ring with blood circulation.
(iii) in the mature blood vessel stage: the generation of special myocyte can provide structural support for newly-generated vascular canal, the growth of neovascularity is made to keep stable.Blood starts at newly-generated intravascular flow.These neovascularity be exactly tumor depend on for existence containing the structure enriching nutrient and blood, make tumor can ramp spreading in vivo.Do not have this environment, newborn tumor tissues will be confined within about scope of 1 cubic millimeter, because lack nutrient conveying and refuse to discharge blood circulation and the extinction that suffocates by the encirclement of the Excreta of cell self.
The new vessels of malignant tissue has common common characteristic.These features comprise " unique vascular morphology " and " new vascular generation feature ".Whether dynamic optical imager can detect this feature, and can be used for assisted diagnosis malignant tissue and exist.This feature that tumor neovasculature generates is very not identical with inflammation simple under benign state, has the feature that following tumor neovasculature generates:
(i) high density and high blood content: for tumor provides the blood vessel of nutrient more than the blood vessel of normal structure, closeer.By using Angiography, imaging is carried out to several groups of breast carcinoma.Microvessel density around cancerous tumours is maximum compared with other places.
(ii) resistance of blood flow: for the blood vessel of supporting tumor to generate shows the resistance of blood flow larger than normal blood vessels under slight pressurization.
(iii) vascular leakage: for the blood vessel of supporting tumor to generate there will be the phenomenon of blood vessel (wall) seepage under external pressure.Blood vessel wall due to tumor region has higher permeability, so the space flowing pressure of tumor area is higher, it and blood capillary pressure close to and balance with its maintenance.The space flowing pressure of this phenomenon and normal structure forms a sharp contrast.In tumor area, this high-voidage flowing pressure can cause the necrosis of endothelium and the seepage of blood vessel.
(iv) oxygen consumption and light propagation attenuation: because tumor quick growth fraction normal structure needs more oxygen, entrained by the blood vessel generated for supporting tumor, the consumption of blood oxygen will be quite large.In addition, oxygen-free blood has light propagation attenuation characteristics.
When tumor growth is to more than one cubic millimeter of (1mm
3) after, just need vasoganglion to supply nutrient and oxygen and excrete wastes.The angiopoietic complex process of this inside tumor is called as tumor " new vascular generation ".In breast carcinoma field, tumor neovasculature generates and clinical meaning is research emphasis always.High microvessel density in breast carcinoma is relevant with the trend that neoplasm metastasis spreads.Breast carcinoma is a kind of disease relying on new vascular generation, and all solid tumors, once grow blood supply system, just likely change malignant tumor into.New vascular generation is the process that tumor growth forms neovascularity, and this process makes tumor can obtain nutrient and discharge refuse.
Summary of the invention
Technical problem to be solved by this invention is: for the deficiency of existing diagnostic device, provides a kind of image-taking system of the equipment in order to diagnosing mammary cancer.
For realizing the object of the present invention, be achieved by the following technical solutions: a kind of image-taking system of breast cancer diagnosis apparatus, include installing rack, be arranged on installing rack one in order to produce the LED light source of infrared light, and be arranged on installing rack above LED light source one and send through LED light source in order to receive and to penetrate the image collection module of the infrared light by inspection breast; The infrared light wavelength that described LED light source produces is between 620nm and 685nm; Described image collection module includes one in order to take the ccd video camera of dynamic image, and one in order to extrude the air bag of breast; Described air bag is connected with an air accumulator with a vacuum tank by pipeline, air bag and vacuum tank, the tank connected pipeline of gas storage are connected to electromagnetic valve, be connected with air between air accumulator and vacuum tank from the compressor in vacuum tank suction air accumulator, be provided with air pressure probe in air bag and air accumulator, described air pressure probe and two electromagnetic valves are electrically connected with a controller.
Preferably: described LED light source includes multiple LED with array arrangement and formed, LED send infrared light wavelength be 640nm.
Preferably: described installing rack includes a video camera mounting plate longitudinally arranged, be connected to an infrared installing rack of side, video camera mounting plate bottom, and be connected to the crane of video camera mounting plate lower end, described crane longitudinal sliding motion is arranged on an elevating bracket, described LED light source is fixedly mounted on infrared installing rack, and described ccd video camera is fixedly mounted on video camera mounting plate.
Preferably: the angle forming 50-60 degree residing for described infrared installing rack between plane and video camera mounting plate.
Preferably: described image collection module includes a shooting hood, described shooting hood is fixedly mounted on described video camera mounting plate, described ccd video camera is arranged in shooting hood near the side of video camera mounting plate, be connected with a soft air-bag support below described shooting hood, described air bag is fixed on air-bag support.
Preferably: described LED is welded on a wiring board and forms array, on wiring board, from outer to inner the capable often row of 1-7 is uniformly distributed 15 LED, eighth row is uniformly distributed 13 LED, 9th row is uniformly distributed 9 LED, line-spacing between LED and row are apart from being 0.5 inch, and LED array is symmetrical.
Compared with prior art, the invention has the beneficial effects as follows: image-taking system of the present invention applies equally distributed pressure by air bag to mammary gland and orders about blood content and deoxyhemoglobin generation significantly change.Specifically, the pressure of air bag makes blood penetration in new vascular generation structure bending around tumor around tumor, thus forms the congested region that is equivalent to gross tumor volume about 4 times, is called tumor blood bed.The blood penetrated into around tumor becomes faster than normal structure 4 times of the speed of deoxidation blood, and blood oxygen exchanges and carries out in blood capillary region.This equipment to obtain after dynamic image through computer disposal by ccd video camera, can demonstrate blood volume and deoxyhemoglobin feature over time over the display.More to the absorption of light in malignant areas, so its brightness in the dynamic image of ccd video camera acquisition is lower, provide higher image intensity contrast's degree.And normal or benign tissue has normal vascularity, metabolic rate is lower, and light absorption does not have large change, so they are higher than the brightness of malignant tumor.The blood volume that this equipment Inspection is arrived and the breast malignant lesions feature of these two aspect ratios of high metabolic rate detected by traditional (X light, ultrasonic, nuclear-magnetism, PET etc.) image method take early 6-8.
Accompanying drawing explanation
Fig. 1 is the structural representation of present device.
Fig. 2 is the decomposition texture schematic diagram of present device.
Fig. 3 is the structural representation of installing rack and LED light source part.
Fig. 4 is the structural representation of image collection module part.
1, base; 11, roller; 12, deflecting roller; 2, control chamber; 21, antinose-dive leg; 22, upper cover plate; 23, side cover plate; 24, link; 3, display; 4, elevating bracket; 41, case; 42, elevating lever; 5, installing rack; 51, crane; 52, infrared installing rack; 53, video camera mounting plate; 6, LED light source; 7, image collection module; 70, air accumulator; 71, shooting hood; 72, air bag; 73, air-bag support; 74, ccd video camera; 8, computer.
Detailed description of the invention
With reference to the accompanying drawings the specific embodiment of the present invention is made a detailed explanation below.
According to shown in Fig. 1 to Fig. 4, the image-taking system of a kind of breast cancer diagnosis apparatus described in the present embodiment, include installing rack 5, be arranged on installing rack one in order to produce the LED light source 6 of infrared light, and be arranged on installing rack above LED light source one and send through LED light source in order to receive and to penetrate the image collection module 7 of the infrared light by inspection breast; The infrared light wavelength that described LED light source produces is between 620nm and 685nm; Described image collection module includes one in order to take the ccd video camera 74 of dynamic image, and one in order to extrude the air bag 72 of breast; Described air bag is connected with an air accumulator 70 with a vacuum tank by pipeline, air bag and vacuum tank, the tank connected pipeline of gas storage are connected to electromagnetic valve, be connected with air between air accumulator and vacuum tank from the compressor in vacuum tank suction air accumulator, be provided with air pressure probe in air bag and air accumulator, described air pressure probe and two electromagnetic valves are electrically connected with a controller.
Described LED light source and ccd video camera are electrically connected with computer, and described compressor and electromagnetic valve are electrically connected with controller, and be connected by data wire between controller with computer and communicate, the control command of controller is sent by computer.
Described LED light source includes multiple LED with array arrangement and is formed, LED send infrared light wavelength be 640nm.
Described installing rack includes a video camera mounting plate 53 longitudinally arranged, be connected to an infrared installing rack 52 of side, video camera mounting plate bottom, and be connected to the crane 51 of video camera mounting plate lower end, described crane longitudinal sliding motion is arranged on an elevating bracket 4, the elevating lever 42 coordinating with crane and be slidably connected is installed in elevating bracket, described LED light source is fixedly mounted on infrared installing rack, and described ccd video camera is fixedly mounted on video camera mounting plate.
The angle of 50-60 degree is formed between plane and video camera mounting plate residing for described infrared installing rack.
Described image collection module includes a shooting hood 71, described shooting hood is fixedly mounted on described video camera mounting plate, described ccd video camera is arranged in shooting hood near the side of video camera mounting plate, be connected with a soft air-bag support 73 below described shooting hood, described air bag is fixed on air-bag support.
Described LED is welded on a wiring board and forms array, on wiring board, from outer to inner the capable often row of 1-7 is uniformly distributed 15 LED, and eighth row is uniformly distributed 13 LED, and the 9th row is uniformly distributed 9 LED, line-spacing between LED and row are apart from being 0.5 inch, and LED array is symmetrical.
Controller controls compressor operating, make, in air accumulator and vacuum tank, there is certain air pressure and vacuum, then by the electromagnetic valve that controller opens is connected with air accumulator when will increase the pressure of air bag like this, then by electromagnetic valve that controller opens is connected with vacuum tank when reduce the pressure of air bag.
Breast cancer diagnosis apparatus also includes control chamber 2, and installing rack 5 is positioned at control chamber side, is provided with the display 3 be connected with computer above described control chamber.Described control chamber is fixedly mounted on a base 1, and side base being positioned at control chamber is installed with described elevating bracket 4.Described base is provided with two rollers 11 and two deflecting rollers 12, described base is provided with the case 41 that covers elevating bracket.
Described control chamber includes the antinose-dive leg 21 of a rectangular shape, and the upper cover plate 22 be connected to above antinose-dive leg and the side cover plate 23 be connected on antinose-dive leg four side wall surfaces, and antinose-dive leg is connected with a link 24 in order to fixing elevating bracket on the side wall surface of elevating bracket side.
Described air bag is an irregular hexahedron, and wherein five is non-elastic material, and another side (lower plane) is transparent pellosil.Pellosil during airbag aeration is outwards expanded and the tissue that gently pressure is detected.Under the effect of external pressure, detected in-house blood has significantly different reactions in the flowing of normal blood vessels and the flowing in tumor neogenetic blood vessels, and has different optical characteristics and infiltration function.Pressure adjustable in air bag.
Described ccd video camera is in testing process, and ccd video camera collection is detected the dynamic optical information of tissue, and is real-time transmitted to computer and does further process.In breast examination process, LED sends the near infrared light of 640nm wavelength from breast bottom, the transparent silicon glued membrane of air bag gently presses detected breast after inflation simultaneously, LED light penetrates skin of mammary gland and soft tissue arriving signal receptor and ccd video camera, ccd video camera gathers in real time through breast tissue and carries the optical signal of its physiologic information, and carries these optical signallings to computer.Image processing software is had to carry out real-time analyzing and processing and medical judgment to the information of ccd video camera collection in computer.
The process obtaining galactophore image is as follows:
1. LED light source is in closed condition, and ccd video camera gathers the reflected image of breast, and computer system calculates and obtains breast contours image;
2. LED light source automatic or manual is adjusted to appropriate brightness, and ccd video camera starts the infrared transmission figure gathering breast;
3., when gasbag pressurizes is to 5mmHg pressure, computer system gathers a reference picture Iref;
4. air bag is forced into 10mmHg pressure successively, drops to 5mmHg pressure, then drops to 0mmHg pressure, the dynamic image series I (x, y, t) of computer system collection;
5. computer calculate obtains each spatial point (x, y) of breast to the response value DS (x, y, t) of pressure
DS(x， y， t)=[I(x，y，t)–Iref ]/Iref；
6. three-dimensional reconstruction.
Can be there is strong scattering and diffusion through during mammary gland tissue in light beam, cause spatial resolution very low, and a therefore independent still image can not reflect the information of enough abnormal vascular distributions, and the detected numerical value only having blood volume and oxygen capacity.Complete image series then can show the dynamic change of mammary gland under pressure modulation.Dynamic image series can use I (x, y, t) function representation.Piece image Iref after dynamic optical breast cancer detection system adopts pressure to increase is as reference image, and it is first perspective view after breast shape is stablized.Other image values in the image series gathered by ccd video camera deduct this width image value, then just Dynamic Signal is represented divided by its result of Iref [DS (x, y, t)], each spatial point (x, y) is to the reaction of pressure in other words conj.or perhaps.
DS(x，y，t) = [I(x，y，t)–Iref]/Iref
The angiosomes relevant to canceration absorbs more light than normal structure, and this will generate the lower region of a brightness degree on image.When the light that LED the sends new vascular generation run into around tumor is organized, the hemoglobin leaked in the blood capillary near malignant change absorbs more light than normal or benign tissue.Along with each pressure increases, the change of light transmission under computer recording.Compared with normal region, the blood volume in the region of abnormal vascular distribution, abnormal space fluid pressure and abnormal consumption rate and blood oxygen saturation then decline with different ratios.Therefore, normal dynamic signal (DSn) and the Anomalous dynamics signal (DSa) of same detected tissue have significant difference, can represent with lower inequality:
DSa (xa，ya，t) ≠ DSn(xn， yn， t)
In order to process the image of camera record, dynamic optical breast cancer detection system adopts unique computerized algorithm to generate time dependent optical transport data pattern on each position.Therefore, it is the blood vessel feature by view performance mammary gland new vascular generation region uniqueness, thus compares with blood vessel that is normal or benign breast tissue regions.By this contrast display, dynamic optical breast cancer detection system just likely confirms the existence of canceration in mammary gland, and the canceration in breast and benign lesion and normal structure is distinguished and come.
The image information that ccd video camera gathers send into described in computer, and the dynamic optical image processing software as calculated in machine process in real time with image reconstruction after show the dynamic function image of mammary gland tissue over the display.The state of the dynamic function image of mammary gland tissue depends on the anatomical structure of breast tissue, physio-pathological condition and the active intensity penetrating near infrared light.Usually, fatty tissue is high printing opacity, and fibrous tissue, gland tissue and skin are low light transmissions.Blood (mainly hemoglobin) light transmission is minimum, and that is hemoglobin is the strongest to the absorbability of the near infrared light of 640nm wavelength, and skin color does not affect image.The combination of these factors, constitutes dynamic optical Diagnosis of Breast Tumor imaging characteristics.Require during computer infrared light scanning to carry out in darkroom.By the propagation characteristic of research light in tissue, based on the algorithm of dynamic optical imaging, just can rebuild image, thus the concentration change detecting HbO2 Oxyhemoglobin in tissue, deoxyhemoglobin and whole blood Lactoferrin can be represented intuitively.
Behavioral characteristics takes from each region (pixel) of record image.Because the dynamic response in pathology effects district of malignant tissue is very different from the dynamic response in normal structure district, medical worker clearly can identify the difference of this feature by contrast.In addition, be easy to make medical worker observe and pathological classification, system application cross correlation algorithm constructs a function image.In the crosscorrelation process used in systematic function image process, one " reference signal " is taken out by from normal galactophore tissue.Afterwards, this reference signal is used to carry out crosscorrelation process to the Dynamic Signal of all mammary region.Because the Dynamic Signal of all normal regions and reference signal are similar, therefore these normal regions just have very high degree of association.But the Dynamic Signal in pathology effects district of malignant tissue and reference signal difference are very large, and these pernicious region degree of association are just very low.Therefore, the result of relevant treatment just creates the function image of high-contrast.In this function image, bright intense part represents normal district, and dark intense part represents pernicious pathological area.
During inspection, to be placed in the middle of mammary gland pallet and after being clamped gently by air bag, closeall indoor light, camera just starts to gather image according to the speed arranged in advance, and these images will show with gray scale and color levels at breast.In order to ensure using suitable LED mode scanning, automatic or manual adjustment can be carried out according to the position of pathological changes in the position according to the LED of mammary gland size Selection.After the position of LED is chosen, by selecting manual or automatically adjusting luminous light intensity button, the luminous light intensity of optimum optimization will be set.The luminous light intensity of selected optimum optimization can make the dynamic range being perforated through mammary gland light intensity reach maximum.In this stage, must by coming labelling one (ROI) region interested with the circle at mouse drag cursor place or being imaging center.This area-of-interest can be the suspicious item district that previous clinical finds or Mammography finds, also can be the central area of breast examination.Once confirm that patient mammary gland is correctly located, and the light intensity of all LED and pattern set all, just can start scanning.
View data generates visual angle, axle position bottom mammary gland and the dynamic image at top after treatment.These dynamic images gray scale or pseudo-colours mode can show the transmission light brightness that causes due to pressure change over time, also as film, can show the different temporal characteristicses that focus area shows compared with surrounding tissue by Continuous Play.In addition, can labelling be carried out with computer mouse and inquire about different image-regions and show corresponding time graph.The shape and the amplitude that are presented at the time graph of (X-axis is time (second) corresponding Y-axis is light intensity change percentage ratio (%)) on grid can be described by quantitative and qualitative analysis.As diagnostic tool, image processing software can distinguish time graph and the display galactophore image of each pixel.Present navy blue to the mammary region of pernicious relevant time graph, the mammary region of the time graph relevant to normal structure is then rendered as green.
During pressure modulation, ccd video camera gathers a series of digital picture, and is stored in calculator memory.At present, each mammary gland " scanning " gathers and stores 100 multiple images.Piece image always records situation when not having illumination to penetrate, and it is called as " spacer ".In data processing, all image sequences that other gathers all will deduct this width spacer to eliminate non-zero dark current and other the background noise of CCD.Afterwards, image sequence is by the process through an image standardization process.The uneven brightness distribution collecting image sequence all compensates by this standardisation process.This stage of analysis of image data is called " Image semantic classification ".After pretreatment, system will start to carry out pathological classification analysis according to " behavioral characteristics " described below and " functional imaging " method.
When using this equipment to carry out breast examination, the light that LED is launched records 45 ~ 72 seconds continuously by ccd video camera (charge-coupled image sensor).After breast being held slightly with breast fixed mount, equipment applies slight equally distributed pressure by the air bag that silicone grease is soft to mammary gland tissue, the pressure of air bag, after 5mmHg (initial pressure) stopped for 15 seconds, is increased to 10mmHg (analysis pressure) and continues 30 seconds afterwards.When external pressure stimulation is added in around breast equably, especially at outside initial pressure with after analyzing Pressure stimulation, the Changing Pattern of the blood flow in breast tissue is the function of time.Under the effect of external pressure, it is different from normal galactophore tissue region that doubtful cancerous cell generates blood redistribution in the abnormal vascular region of position, blood capillary and the blood in vascular and blood oxygen condition.When these changes above-mentioned occur, ccd video camera records these changes by the galactophore image before collection pressurization, after pressurization and in pressure process.
In checking process, the image interpretation that dynamic optical imaging system produces is based on two parameters: the chromaticity range of (1) colored window and the performance graph in (2) corresponding selection region.Based on functional imaging program in computer system to the analysis of LED luminous signal, the darker regions evaluated represents the abnormal vascular distributed areas of corresponding enhancing.The new method that corresponding performance graph provides a kind of precision is additionally used for calculating the vascularity pattern of enhancing and effectively predicts new vascular generation region.
Claims (6)
1. the image-taking system of a breast cancer diagnosis apparatus, it is characterized in that: include installing rack, be arranged on installing rack one in order to produce the LED light source of infrared light, and be arranged on installing rack above LED light source one and send through LED light source in order to receive and to penetrate the image collection module of the infrared light by inspection breast; The infrared light wavelength that described LED light source produces is between 620nm and 685nm; Described image collection module includes one in order to take the ccd video camera of dynamic image, and one in order to extrude the air bag of breast; Described air bag is connected with an air accumulator with a vacuum tank by pipeline, air bag and vacuum tank, the tank connected pipeline of gas storage are connected to electromagnetic valve, be connected with air between air accumulator and vacuum tank from the compressor in vacuum tank suction air accumulator, be provided with air pressure probe in air bag and air accumulator, described air pressure probe and two electromagnetic valves are electrically connected with a controller.
2. the image-taking system of a kind of breast cancer diagnosis apparatus according to claim 1, is characterized in that: described LED light source includes multiple LED with array arrangement and formed, LED send infrared light wavelength be 640nm.
3. the image-taking system of a kind of breast cancer diagnosis apparatus according to claim 1 and 2, it is characterized in that: described installing rack includes a video camera mounting plate longitudinally arranged, be connected to an infrared installing rack of side, video camera mounting plate bottom, and be connected to the crane of video camera mounting plate lower end, described crane longitudinal sliding motion is arranged on an elevating bracket, described LED light source is fixedly mounted on infrared installing rack, and described ccd video camera is fixedly mounted on video camera mounting plate.
4. the image-taking system of a kind of breast cancer diagnosis apparatus according to claim 3, is characterized in that: the angle forming 50-60 degree residing for described infrared installing rack between plane and video camera mounting plate.
5. the image-taking system of a kind of breast cancer diagnosis apparatus according to claim 3, it is characterized in that: described image collection module includes a shooting hood, described shooting hood is fixedly mounted on described video camera mounting plate, described ccd video camera is arranged in shooting hood near the side of video camera mounting plate, be connected with a soft air-bag support below described shooting hood, described air bag is fixed on air-bag support.
6. the image-taking system of a kind of breast cancer diagnosis apparatus according to claim 2, it is characterized in that: described LED is welded on a wiring board and forms array, on wiring board, from outer to inner the capable often row of 1-7 is uniformly distributed 15 LED, eighth row is uniformly distributed 13 LED, 9th row is uniformly distributed 9 LED, line-spacing between LED and row are apart from being 0.5 inch, and LED array is symmetrical.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108567444A (en) * | 2018-06-30 | 2018-09-25 | 上海联影医疗科技有限公司 | Mammary gland machine testing plate for forcing and mammary machine |
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| CN108567444A (en) * | 2018-06-30 | 2018-09-25 | 上海联影医疗科技有限公司 | Mammary gland machine testing plate for forcing and mammary machine |
| CN108567444B (en) * | 2018-06-30 | 2023-09-26 | 上海联影医疗科技股份有限公司 | Mammary gland machine detects compression paddle and mammary gland machine |
| JP2020110481A (en) * | 2019-01-16 | 2020-07-27 | 公立大学法人公立諏訪東京理科大学 | Cancer development-suspected site specification device |
| JP7142865B2 (en) | 2019-01-16 | 2022-09-28 | 公立大学法人公立諏訪東京理科大学 | Device for identifying suspected cancerous sites |
| CN111067490A (en) * | 2019-12-16 | 2020-04-28 | 上海国兴医疗器械有限公司 | Breast cancer diagnosis equipment |
| CN111281344A (en) * | 2020-02-26 | 2020-06-16 | 浙江杜比医疗科技有限公司 | Mammary gland imaging system and mammary gland imaging method |
| CN111407238A (en) * | 2020-04-27 | 2020-07-14 | 浙江杜比医疗科技有限公司 | Optical ultrasonic photoacoustic breast cancer detector and medical equipment |
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