CN104491731A - Traditional Chinese medicine decoction for treating spleen-cold and stomach-heat type reflux esophagitis and preparation method thereof - Google Patents
Traditional Chinese medicine decoction for treating spleen-cold and stomach-heat type reflux esophagitis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a traditional Chinese medicine decoction for treating spleen-cold and stomach-heat type reflux esophagitis and a preparation method thereof. The traditional Chinese medicine decoction is prepared from the following medicinal materials in parts by weight: 30-49 parts of sappanwood, 21-36 parts of malus baccata, 20-38 parts of the bulb of fritillary, 15-27 parts of pleionebulbocodioides rolfe, 13-26 parts of fructus sophorae, 8-17 parts of sanguisorba officinalis, 3-11 parts of radix curcumae, 5-16 parts of setose thistle, 2-7 parts of madder root, 1-7 parts of codonopsis pilosula and 3-10 parts of fructus alpiniae oxyphyllae. The traditional Chinese medicine decoction disclosed by the invention is a pure traditional Chinese medicine formula which is small in toxic and side effects, good in treatment effect, short in treatment course, high in curative rate when used for treating the spleen-cold and stomach-heat type reflux esophagitis, wide in medicine sources, low in cost and suitable for clinical popularization and application.
Description
Technical field
The present invention relates to and a kind ofly treat Chinese medicine decoction of spleen-cold syndrome stomach heat type reflux esophagitis and preparation method thereof.
Background technology
Reflux esophagitis (RefluxEsophagitis, RE), means because stomach and (or) duodenum content reflux enter esophagus, causes the pathological changes such as the inflammation of Esophageal Mucosa, erosion, ulcer and fibrosis, belong to gastroesophageal reflux disease.Clinically to combine with histamine H2 receptor antagonist or proton pump inhibitor (PPI) with dopamine antagonist or cisapride, as reflux esophagitis conventional therapy, there is certain curative effect, but the state of an illness easily repeatedly, alleviate belch and dysphagia symptom not obvious, limit the application that it is clinical to a certain extent.The clinical symptoms of spleen-cold syndrome stomach heat type reflux esophagitis has: upper abdomen dull pain, and tastelessness is indigestion and loss of appetite, loose stool, and spiritlessness and weakness, becomes thin, light purplish tongue, thready and hesitant pulse.Long-term practice through inventor draws, Chinese medicine is controlled spleen-cold syndrome stomach heat type reflux esophagitis and had better effect, obtains good effect.
Spleen-cold syndrome stomach heat type is shown in that dysphagia, retrosternal pain, spiritlessness and weakness, lusterless complexion, emaciated physique, light red tongue are dark, there is petechia on tongue limit.
Summary of the invention
Technical problem to be solved by this invention is to provide that a kind of therapeutic effect is good, effective percentage is high, Chinese medicine decoction to the spleen-cold syndrome stomach heat type reflux esophagitis of human non-toxic's side effect, and non-relapse after healing, also provides a kind of method preparing Chinese medicine decoction simultaneously.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
The Chinese medicine decoction for the treatment of spleen-cold syndrome stomach heat type reflux esophagitis provided by the invention, be prepared from by the medical material of following weight proportion: Lignum Sappan 30-49 part, dwarf apple 21-36 part, Bulbus Fritillariae Uninbracteatae 20-38 part, pleionebulbocodioides rolfe 15-27 part, Fructus Sophorae 13-26 part, Radix Sanguisorbae 8-17 part, Radix Curcumae 3-11 part, Radix Cirsii Japonici 5-16 part, Radix Rubiae 2-7 part, Radix Codonopsis 1-7 part, Fructus Alpiniae Oxyphyllae 3-10 part.
Preferably, described Chinese medicine decoction is prepared from by the medical material of following weight proportion: Lignum Sappan 49 parts, dwarf apple 36 parts, Bulbus Fritillariae Uninbracteatae 38 parts, pleionebulbocodioides rolfe 27 parts, the Fructus Sophorae 26 parts, Radix Sanguisorbae 17 parts, Radix Curcumae 11 parts, Radix Cirsii Japonici 16 parts, Radix Rubiae 7 parts, Radix Codonopsis 7 parts, Fructus Alpiniae Oxyphyllae 10 parts.
Preferably, described Chinese medicine decoction is prepared from by the medical material of following weight proportion: Lignum Sappan 30 parts, dwarf apple 21 parts, Bulbus Fritillariae Uninbracteatae 20 parts, pleionebulbocodioides rolfe 15 parts, the Fructus Sophorae 13 parts, Radix Sanguisorbae 8 parts, Radix Curcumae 3 parts, Radix Cirsii Japonici 5 parts, Radix Rubiae 2 parts, Radix Codonopsis 1 part, Fructus Alpiniae Oxyphyllae 3 parts.
Preferably, described Chinese medicine decoction is prepared from by the medical material of following weight proportion: Lignum Sappan 35 parts, dwarf apple 28 parts, Bulbus Fritillariae Uninbracteatae 29 parts, pleionebulbocodioides rolfe 21 parts, the Fructus Sophorae 19 parts, Radix Sanguisorbae 13 parts, Radix Curcumae 6 parts, Radix Cirsii Japonici 9 parts, Radix Rubiae 5 parts, Radix Codonopsis 3 parts, Fructus Alpiniae Oxyphyllae 6 parts.
The present invention also provides the method preparing above-mentioned Chinese medicine decoction, comprises the following steps:
(1) get above-mentioned Chinese crude drug according to weight proportion, adding weight is medical material gross weight 6-10 water doubly, and 65-70 degree Celsius is soaked 18-25 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained;
Preferably, the medical material in step (1) is ground to form 300-500 object powder.
The water temperature gradient that the invention provides in a kind of step (2) is elevated to the mode of boiling, specifically: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.
The instructions of taking of medicine provided by the invention is: every day 1 dose, each 400-600 milliliter, every day 2 times, within 20 days, is 1 course for the treatment of.
Beneficial effect of the present invention:
The present invention is used for clinical, not only eliminate clinical symptoms fast and control its mark, and make spleen-cold syndrome stomach heat type patients with reflux esophagitis healing Zhi Qiben in a short time, institute's rate of relapse in patients of controlling is low, particularly to the patient of Relapse rate outbreak after treating with Chinese and western drugs, the good therapeutic effect that oral Chinese medicine decoction of the present invention has thorough healing no longer to recur equally, has no untoward reaction and occurs, and can also strengthen body immunity in clinical practice.
The present invention is pure Chinese medicinal formulae, and toxic and side effects is little, good effect, short treating period, be used for the treatment of spleen-cold syndrome stomach heat type reflux esophagitis cure rate high, and its medicine source is wide, cost is low, be suitable for clinical application.
Detailed description of the invention
embodiment 1 clinical verification
The Chinese medicine decoction that the present embodiment provides is prepared from by the medical material of following weight proportion: Lignum Sappan 35 grams, dwarf apple 28 grams, Bulbus Fritillariae Uninbracteatae 29 grams, pleionebulbocodioides rolfe 21 grams, the Fructus Sophorae 19 grams, Radix Sanguisorbae 13 grams, Radix Curcumae 6 grams, Radix Cirsii Japonici 9 grams, Radix Rubiae 5 grams, Radix Codonopsis 3 grams, Fructus Alpiniae Oxyphyllae 6 grams.
The method of above-mentioned Chinese medicine decoction, comprises the following steps:
(1) get above-mentioned Chinese crude drug according to weight proportion, medical material is ground to form 300-500 object powder, add the water that weight is medical material gross weight 8 times, 67 degrees Celsius are soaked 23 hours;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 25 minutes, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 3 times, merge the medicinal liquid of gained;
Water temperature gradient in step (2) is elevated to the mode of boiling, specifically: water temperature raises 10 degrees Celsius in every 4 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes.
The instructions of taking of the present embodiment medicine is: every day 1 dose, each 400-600 milliliter, every day 2 times, within 20 days, is 1 course for the treatment of.
The routine patient of Chinese medicine decoction clinical observation spleen-cold syndrome stomach heat type reflux esophagitis 135 of the present embodiment, clinical report is as follows:
1, physical data
In 135 routine patients, in age 20-71 year, the course of disease is many at 4 months to 3 years, 39 years old mean age.
2, diagnostic criteria
" Chinese medical disease Standardization of diagnosis and curative effect " that diagnosis basis State Administration of Traditional Chinese Medicine issues:
(1) reflux symptom is had;
(2) performance of spleen-cold syndrome stomach heat type reflux esophagitis may be had under scope;
(3) patient has causalgia after typical breastbone, heartburn, acid regurgitation symptom.Get rid of stomach and esophageal surgery history, esophagostenosis, upper digestive tract malignant change, constitutional dyskinesis, serious accompanying diseases, anemia of pregnant woman and breast-feeding female.
Tcm clinical practice symptom: upper abdomen dull pain, tastelessness, indigestion and loss of appetite, loose stool, spiritlessness and weakness, becomes thin, light purplish tongue, thready and hesitant pulse.
3, Therapeutic Method
Take the Traditional Chinese medicine formula preparation that the present embodiment provides.
4, therapeutic outcome:
4.1 formulate with reference to " Chinese medical disease Standardization of diagnosis and curative effect ":
Cure: symptom disappears completely, the erosion of gastroscope check Esophageal Mucosa disappears or substantially disappears;
Effective: symptom is clearly better or substantially disappears, gastroscope check Esophageal Mucosa erosion disappearance more than 1/2 person;
Invalid: symptom is improved not obvious, Esophageal Mucosa erosion disappearance less than 1/2 person under gastroscope.
4.2 results: in 135 routine patients, clinical cure 96 example, effective 29 examples, invalid 10 examples, total effective rate is 92.5%.
embodiment 2
The Chinese medicine decoction that the present embodiment provides is prepared from by the medical material of following weight proportion: Lignum Sappan 49 grams, dwarf apple 36 grams, Bulbus Fritillariae Uninbracteatae 38 grams, pleionebulbocodioides rolfe 27 grams, the Fructus Sophorae 26 grams, Radix Sanguisorbae 17 grams, Radix Curcumae 11 grams, Radix Cirsii Japonici 16 grams, Radix Rubiae 7 grams, Radix Codonopsis 7 grams, Fructus Alpiniae Oxyphyllae 10 grams.
The method of above-mentioned Chinese medicine decoction, comprises the following steps:
(1) get above-mentioned Chinese crude drug according to weight proportion, add the water that weight is medical material gross weight 10 times, 70 degrees Celsius are soaked 25 hours;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 30 minutes, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 5 times, merge the medicinal liquid of gained;
Medical material in step (1) is ground to form 500 object powder.
Water temperature gradient in step (2) is elevated to the mode of boiling, specifically: water temperature raises 10 degrees Celsius in every 5 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes.
embodiment 3
The Chinese medicine decoction that the present embodiment provides is prepared from by the medical material of following weight proportion: Lignum Sappan 30 grams, dwarf apple 21 grams, Bulbus Fritillariae Uninbracteatae 20 grams, pleionebulbocodioides rolfe 15 grams, the Fructus Sophorae 13 grams, Radix Sanguisorbae 8 grams, Radix Curcumae 3 grams, Radix Cirsii Japonici 5 grams, Radix Rubiae 2 grams, Radix Codonopsis 1 gram, Fructus Alpiniae Oxyphyllae 3 grams.
The method of above-mentioned Chinese medicine decoction, comprises the following steps:
(1) get above-mentioned Chinese crude drug according to weight proportion, add the water that weight is medical material gross weight 6 times, 65 degrees Celsius are soaked 18 hours;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20 minutes, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2 times, merge the medicinal liquid of gained;
Medical material in step (1) is ground to form 300 object powder.
Water temperature gradient in step (2) is elevated to the mode of boiling, specifically: water temperature raises 10 degrees Celsius in every 3 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes.
model case:
1, Song, female, 63 years old.Sample pain is burnt, attackaftermeals of being everlasting after patient's readme breastbone, and with belch pantothenic acid, spiritlessness and weakness, middle upper abdomen dull pain.Look into time medical: face is sallow, food of receiving is not good enough, and body of the tongue is light red ecchymosis, white and thin fur, deep-thready pulse.The visible Esophageal Mucosa of gastroscopy is congested, edema, and there are rotten to the corn and shallow table ulcer in surface, is diagnosed as spleen-cold syndrome stomach heat type reflux esophagitis.Take medicine of the present invention, treat 3 courses for the treatment of, symptom obviously alleviates, and continues to take 2 courses for the treatment of, and recovery from illness, follows up a case by regular visits to and have no recurrence in 6 months.
2, willow, man, 51 years old, suffer from gastropathy for many years, gastral cavilty top was swollen, scorching hot, retrosternal pain, and with pantothenic acid, heartburn, xerostomia, bitter taste, drink water more, constipation with dry stool, sleeps night not peaceful.Gastroscopy: chronic atrophic gastritis companion gastric antrum erosion, spleen-cold syndrome stomach heat type reflux esophagitis II level.Take medicine of the present invention, every day 1 dose, after 2 courses for the treatment of, symptom is clearly better, and continues to take 3 courses for the treatment of, and recovery from illness, follows up a case by regular visits to and have no recurrence in 6 months.
3, Huang, man, 52 years old, the heartburn acid regurgitation of readme more than 1 year, occurred heartburn without obvious inducement before 1 year, acid regurgitation, felt sick, belch frequency, bitter taste, gastral cavity abdomen fear of cold.Gastroscopy: distal esophagus mucosa is congested, rotten to the corn and ooze out, chronic gastritis.Be diagnosed as spleen-cold syndrome stomach heat type reflux esophagitis.Take medicine of the present invention, every day 1 dose, after 2 courses for the treatment of, symptom is clearly better, and continues to take 3 courses for the treatment of, and recovery from illness, follows up a case by regular visits to and have no recurrence in 6 months.
Claims (6)
1. treat a Chinese medicine decoction for spleen-cold syndrome stomach heat type reflux esophagitis, it is characterized in that, be prepared from by the medical material of following weight proportion: Lignum Sappan 30-49 part, dwarf apple 21-36 part, Bulbus Fritillariae Uninbracteatae 20-38 part, pleionebulbocodioides rolfe 15-27 part, Fructus Sophorae 13-26 part, Radix Sanguisorbae 8-17 part, Radix Curcumae 3-11 part, Radix Cirsii Japonici 5-16 part, Radix Rubiae 2-7 part, Radix Codonopsis 1-7 part, Fructus Alpiniae Oxyphyllae 3-10 part.
2. Chinese medicine decoction according to claim 1, is characterized in that, is prepared from by the medical material of following weight proportion: Lignum Sappan 49 parts, dwarf apple 36 parts, Bulbus Fritillariae Uninbracteatae 38 parts, pleionebulbocodioides rolfe 27 parts, the Fructus Sophorae 26 parts, Radix Sanguisorbae 17 parts, Radix Curcumae 11 parts, Radix Cirsii Japonici 16 parts, Radix Rubiae 7 parts, Radix Codonopsis 7 parts, Fructus Alpiniae Oxyphyllae 10 parts.
3. Chinese medicine decoction according to claim 1, is characterized in that, is prepared from by the medical material of following weight proportion: Lignum Sappan 30 parts, dwarf apple 21 parts, Bulbus Fritillariae Uninbracteatae 20 parts, pleionebulbocodioides rolfe 15 parts, the Fructus Sophorae 13 parts, Radix Sanguisorbae 8 parts, Radix Curcumae 3 parts, Radix Cirsii Japonici 5 parts, Radix Rubiae 2 parts, Radix Codonopsis 1 part, Fructus Alpiniae Oxyphyllae 3 parts.
4. Chinese medicine decoction according to claim 1, is characterized in that, is prepared from by the medical material of following weight proportion: Lignum Sappan 35 parts, dwarf apple 28 parts, Bulbus Fritillariae Uninbracteatae 29 parts, pleionebulbocodioides rolfe 21 parts, the Fructus Sophorae 19 parts, Radix Sanguisorbae 13 parts, Radix Curcumae 6 parts, Radix Cirsii Japonici 9 parts, Radix Rubiae 5 parts, Radix Codonopsis 3 parts, Fructus Alpiniae Oxyphyllae 6 parts.
5. the method for the Chinese medicine decoction of preparation described in above-mentioned any one claim, is characterized in that, comprise the following steps:
(1) get above-mentioned Chinese crude drug according to weight proportion, adding weight is medical material gross weight 6-10 water doubly, and 65-70 degree Celsius is soaked 18-25 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained;
The preparation method of Chinese medicine decoction according to claim 5, is characterized in that, the medical material in step (1) is ground to form 300-500 object powder.
6. the preparation method of Chinese medicine decoction according to claim 5, is characterized in that, the mode that the water temperature gradient in step (2) is elevated to boiling is: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.
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CN104547323A (en) * | 2014-12-26 | 2015-04-29 | 赵红 | Traditional Chinese medicine for treating spleen-deficiency and qi-stagnation reflux esophagitis, and preparation method of traditional Chinese medicine |
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Cited By (1)
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CN104547323A (en) * | 2014-12-26 | 2015-04-29 | 赵红 | Traditional Chinese medicine for treating spleen-deficiency and qi-stagnation reflux esophagitis, and preparation method of traditional Chinese medicine |
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