CN104491659A - Traditional Chinese medicine preparation for treating acute rheumatism - Google Patents
Traditional Chinese medicine preparation for treating acute rheumatism Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating acute rheumatism. The traditional Chinese medicine preparation comprises the following raw materials by weight: 20-30g of cassia twig, 10-20g of notopterygium root, 10-20g of long-noded pit viper, 10-20g of pawpaw, 10-20g of homalomena occulta, 10-20g of berba aristolochiae mollissimae, 10-20g of apricot kernels, 10-20g of medicinal cyathula root, 10-20g of radix sophorae flavescentis, 8-15g of oriental wormwood, 8-12g of flos carthami, 8-12g of pericarpium citri reticulatae, 8-12g of schizophragma integrifolium, 8-12g of radix rehmanniae preparata, 8-12g of kadsura pepper stem and 8-12g of medicated leaven. All the components of the traditional Chinese medicine preparation are excellent in compatibility and cooperate for exerting the effects of tonifying liver and kidney, expelling wind and removing dampness, activating blood circulation to dissipate blood stasis, strengthening tendons and bones, easing joint movement, and activating meridians to stop pain; the traditional Chinese medicine preparation is an effective medicine for controlling pathogenic condition in the stage of attack of the acute rheumatism and is worthy to popularize and apply clinically.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation can treating rheumatic fever.
Background technology
Rheumatic fever is a kind of systemic disease of easy recurrent exerbation, is mainly to involve the collagen fiber of connective tissue and the nonsuppurative inflammation of substrate, becomes feature, mainly invades heart, joint, also can involve skin, cerebral tissue, blood vessel and serous coat so that rheumatism is little.Rheumatic fever is the operational phase of acute attack in the rheumatism course of disease, is a kind of nonsuppurative inflammation, and it to betide after streptococcal infection 2 ~ 4 weeks usually.Typical clinical manifestation comprises the various combination of wandering arthritis, carditis, erythema marginatum (erythema iris), subcutaneous nodule, Sydenham chorea, heating, toxemia etc., and recurrent exerbation can cause cardiac valve permanent lesion.The patient of about 75% has arthritis.Usually comparatively obvious with arthritis during acute attack, but can patient death be caused in this stage rheumatic carditis.The heart damage that weight does not wait often is left over after the outbreak of anxious bosom, especially remarkable with valve pathological changes, form chronic rheumatic heart disease or rheumatic valvular disease.
The treatment of modern medicine is still based on anti-inflammatory analgesic, but the hormone medicine toxic and side effects such as most anti-inflammatory and antalgic are bigger than normal, easily cause the drawback such as complication and various drug resistance, and medical expense are expensive, a lot of patient is owing to being difficult to bear high medical expense, affect the state of an illness adversely, although and Western medicine curative effect fast, cure the symptoms, not the disease, root cannot be removed, easy recurrence, causes the state of an illness to be prolonged continuous without cease, brings have a strong impact on to minimal invasive treatment.Therefore, in recent years, to treat, the principle for the treatment of both the principal and secondary aspects of a disease according to differential diagnosis in tcm, we utilize this disease of the fried pharmaceutical treatment of multiple Chinese herbal medicine to obtain good efficacy.
Summary of the invention
The invention solves the defect existed in treatment rheumatic fever at present, provide a kind of determined curative effect, have no side effect, the high and Chinese medicine preparation not easily recurred of cure rate.
The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of rheumatic fever, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 20-30 gram, Rhizoma alpiniae chinensis 10-20 gram, Agkistrodon 10-20 gram, Fructus Chaenomelis 10-20 gram, Rhizoma Homalomenae 10-20 gram, Herba Aristolochiae Mollissimae 10-20 gram, Semen Armeniacae Amarum 10-20 gram, Radix Cyathulae 10-20 gram, Radix Sophorae Flavescentis 10-20 gram, Herba Artemisiae Scopariae 8-15 gram, Flos Carthami 8-12 gram, Pericarpium Citri Reticulatae 8-12 gram, Cortex schizophragmatis integrifolii radicis 8-12 gram, Radix Rehmanniae Preparata 8-12 gram, Caulis Piperis Kadsurae 8-12 gram, Massa Medicata Fermentata 8-12 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 20 grams, Rhizoma alpiniae chinensis 10 grams, Agkistrodon 10 grams, Fructus Chaenomelis 10 grams, Rhizoma Homalomenae 10 grams, Herba Aristolochiae Mollissimae 10 grams, 10 grams, Semen Armeniacae Amarum, Radix Cyathulae 10 grams, Radix Sophorae Flavescentis 10 grams, Herba Artemisiae Scopariae 8 grams, 8 grams, Flos Carthami, Pericarpium Citri Reticulatae 8 grams, Cortex schizophragmatis integrifolii radicis 8 grams, 8 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 8 grams, Massa Medicata Fermentata 8 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 25 grams, Rhizoma alpiniae chinensis 15 grams, Agkistrodon 15 grams, Fructus Chaenomelis 15 grams, Rhizoma Homalomenae 15 grams, Herba Aristolochiae Mollissimae 15 grams, 15 grams, Semen Armeniacae Amarum, Radix Cyathulae 15 grams, Radix Sophorae Flavescentis 15 grams, Herba Artemisiae Scopariae 12 grams, 10 grams, Flos Carthami, Pericarpium Citri Reticulatae 10 grams, Cortex schizophragmatis integrifolii radicis 10 grams, 10 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 10 grams, Massa Medicata Fermentata 10 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 30 grams, Rhizoma alpiniae chinensis 20 grams, Agkistrodon 20 grams, Fructus Chaenomelis 20 grams, Rhizoma Homalomenae 20 grams, Herba Aristolochiae Mollissimae 20 grams, 20 grams, Semen Armeniacae Amarum, Radix Cyathulae 20 grams, Radix Sophorae Flavescentis 20 grams, Herba Artemisiae Scopariae 15 grams, 12 grams, Flos Carthami, Pericarpium Citri Reticulatae 12 grams, Cortex schizophragmatis integrifolii radicis 12 grams, 12 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 12 grams, Massa Medicata Fermentata 12 grams.
The instructions of taking of above-mentioned Chinese medicine preparation is: after being mixed by the raw material Chinese medicine of above-mentioned weight proportion, traditionally the method for fried Chinese medicine gets its medicine juice, every day 1 dose, and points 2 ~ 3 times oral.7 doses was 1 course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Ramulus Cinnamomi, acrid in the mouth, sweet, warm in nature; GUIXIN, spleen, urinary bladder channel.There is expelling pathogenic factors from muscles by diaphoresis, warming the meridian for promoting the flow of YANG QI, effect of expelling wind and removing dampness.
Rhizoma alpiniae chinensis, acrid in the mouth, hardship, warm in nature; Return bladder, kidney channel.There is dispelling cold and removing dampness, effect of wind-expelling pain-stopping.
Agkistrodon, salty in the mouth, warm in nature; Return liver, spleen channel.There is dispelling wind and removing obstruction in the collateral, effect of arresting convulsion pain relieving.
Fructus Chaenomelis, sour in the mouth, warm in nature; Return liver, spleen channel.There is relaxing muscles and tendons and activating QI and blood in the collateral, effect of removing dampness to restore normal function of the stomach.
Rhizoma Homalomenae, acrid in the mouth, warm in nature; Return liver, kidney, stomach warp.There is wind-damp dispelling, muscle reinforcing and bone strengthening, effect of promoting blood circulation and stopping pain.
Herba Aristolochiae Mollissimae, acrid in the mouth, hardship, property is put down; Return Liver Channel.There is expelling wind and removing dampness, effect of removing obstruction in the collateral to relieve pain.
Semen Armeniacae Amarum, bitter in the mouth, slightly warm in nature; Return lung, large intestine channel.There is relieving cough and asthma, effect of loosening bowel to relieve constipation.
Radix Cyathulae, bitter in the mouth, acid, property is put down; Return liver, kidney channel.There is nourishing the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, the merit of inducing diuresis for treating stranguria syndrome
Radix Sophorae Flavescentis, bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel.There is heat clearing and damp drying, parasite killing, effect of diuresis.
Herba Artemisiae Scopariae, bitter in the mouth, cold nature; Return spleen, stomach, liver, gallbladder meridian.There is clearing away heat-damp and promoting diuresis, effect of promoting the function of the gallbladder to alleviate jaundice.
Flos Carthami, acrid in the mouth, warm in nature; GUIXIN, Liver Channel.There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain.
Pericarpium Citri Reticulatae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There is regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, effect of diuretic relieving constipation.
Cortex schizophragmatis integrifolii radicis, lightly seasoned, cool in nature; Return spleen channel.There is relaxing muscles and tendons and activating QI and blood in the collateral, effect of expelling wind and activating blood circulation.
Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature; Return liver, kidney channel.There is nourishing the blood and yin, effect of vital essence replenishing and marrow benifiting.
Caulis Piperis Kadsurae, acrid in the mouth, slightly warm in nature; GUIXIN, kidney channel.There is wind-damp dispelling, the meridian dredging, the effect of regulating the flow of vital energy.
Massa Medicata Fermentata, sweet in the mouth, pungent, warm in nature; Return spleen, stomach warp.There is invigorating the spleen and regulating the stomach, effect of promoting digestion and removing stagnation.
Rheumatism belongs to the traditional Chinese medical science " insensitive impediment " category, and Chinese medical discrimination is that disease enters network, expectorant stasis of blood knot for a long time, gos deep into bone joint, the coldheat complex of state of an illness deficiency and excess.Void then belongs to caused by liver and kidney deficiency, insufficiency of vital energy and blood, liver governing tendons, kidney governing bones, deficient qi and blood, immunologic hypofunction; Actually attack outside wind-cold damp pathogen, with the passing of time heat-transformation, the raw expectorant of the raw stasis of blood, the damp and hot stasis of blood of wind and cold hands over resistance, and the four stages in the course of an epidemic febrile disease is obstructed obstructed, therefore hurt like hell.Treatment is worked as with kidney-supplementing liver-boosting, and relaxing muscles and tendons to promote blood circulation, removing obstruction in the collateral to relieve pain is rule for the treatment of.
In Chinese medicine preparation of the present invention, Radix Cyathulae, Radix Rehmanniae Preparata can nourishing the liver and kidney, bone and muscle strengthening, vital essence replenishing and marrow benifiting, promote that QI and blood is two and rise, be equipped with Ramulus Cinnamomi, Rhizoma Homalomenae, can warming the meridian for promoting the flow of YANG QI, and promoting blood circulation and stopping pain, effectively improves body immunity; Rhizoma alpiniae chinensis, Agkistrodon, Herba Aristolochiae Mollissimae can expelling wind and removing dampness, and removing obstruction in the collateral to relieve pain, plays easing joint movement, reducing swelling and alleviating pain effect; Radix Sophorae Flavescentis, Herba Artemisiae Scopariae, Semen Armeniacae Amarum can clearing away heat-damp and promoting diuresis, and diuresis relieving constipation, captures and relieve oedema or abdominal distension through diuresis or purgation, and is equipped with the invigorating the spleen and regulating the stomach of Pericarpium Citri Reticulatae, Massa Medicata Fermentata, Fructus Chaenomelis, the merit of regulating the flow of Qi and the middle Jiao, dispels cold-damp expectorant poison; Cortex schizophragmatis integrifolii radicis, Flos Carthami, Caulis Piperis Kadsurae can dredge the meridian passage, and blood circulation promoting and blood stasis dispelling, improves blood microcirculation, dredging collateral blood vessels, makes general rule not bitterly; Full side's compatibility is superior, plays the liver and the kidney tonifying altogether, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, bone and muscle strengthening, easing joint movement, effect of removing obstruction in the collateral to relieve pain, is the active drug of rheumatic fever stage of attack symptom management, clinic promotion and application.
For investigating clinical efficacy and the safety of medicine of the present invention further, we have selected 98 routine out-patients and have carried out clinical experiment, and patient's all non-acute stage or acute attack stage have the symptoms such as arthroncus is obvious, sharp ache, in a short time function of joint serious hindrance.Man 52 example, female 46 example, age 15-72 year.Wherein rheumatoid arthritis 33 example, rheumatic arthritis 26 example, 12 cases of osteoarthritis, ankylosing spondylitis 5 example, gouty arthritis 6 example, allergic arthritis 16 example; All patients are divided into treatment group and matched group at random, often organize 48 examples, two groups in age, sex, sick kind, the state of an illness etc. without significant difference, there is comparability (P > 0.05).
Criterion of therapeutical effect:
Recovery from illness: arthralgia disappears or alleviates degree to outbreak, and swelling obviously alleviates or disappears, and function of joint is recuperator to some extent;
Take a turn for the better; Arthralgia and swelling alleviate;
Invalid: symptom is unchanged or add severe one.
Therapeutic Method:
Matched group: give leflunomide each 20mg, every day 1 oral medication, the course for the treatment of is 12 weeks.The obvious person of arthralgia can give appropriate nonsteroidal antiinflammatory drug (diclofenac sodium dual-release puts enteric coated capsule 75mg every day) or low dose of hormone (7.5mg every day) oral, be no more than treatment in 4 weeks.
Treatment group: adopt medicine of the present invention, get Ramulus Cinnamomi 25 grams, Rhizoma alpiniae chinensis 15 grams, Agkistrodon 15 grams, Fructus Chaenomelis 15 grams, Rhizoma Homalomenae 15 grams, Herba Aristolochiae Mollissimae 15 grams, 15 grams, Semen Armeniacae Amarum, Radix Cyathulae 15 grams, Radix Sophorae Flavescentis 15 grams, Herba Artemisiae Scopariae 12 grams, 10 grams, Flos Carthami, Pericarpium Citri Reticulatae 10 grams, Cortex schizophragmatis integrifolii radicis 10 grams, 10 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 10 grams, Massa Medicata Fermentata 10 grams (with disease plus-minus), the traditionally method of fried Chinese medicine fried rear every day 1 dose after mixing, points 2 ~ 3 times oral.
Efficacy result:
1. clinical efficacy result:
After treatment, effective 32 examples for the treatment of group, effective 15 examples, invalid 2 examples, obvious effective rate is 65.3%, and effective percentage reaches 95.9%; Effective 22 examples of matched group, effective 14 examples, invalid 13 examples, obvious effective rate is 44.9%, effective percentage 74.4%.Treatment group obvious effective rate and effective percentage are apparently higher than matched group, and two groups of differences have significance (P < 0.05).Detailed results is in table 1.
Table 1: clinical efficacy results contrast table after two groups of treatments
| Group | Number of cases | Recovery from illness n (%) | Improvement n (%) | Invalid n (%) | Effective percentage (%) |
| Treatment group | 49 | 32(65.3) | 15(30.6) | 2(4.1) | 95.9 |
| Matched group | 49 | 22(44.9) | 14(28.8) | 13(26.5) | 73.5 |
2. untoward reaction is compared
There is blood leukocytes decline 5 example in matched group, liver function injury 3 example has obvious gastrointestinal reaction 7 example, hypertension 2 example, and erythra, renal function injury 1 are routine; Treatment group has no affects hepatic and renal function or other serious toxicity persons.
Result shows, Chinese medicine preparation treatment rheumatic fever of the present invention is evident in efficacy, has both avoided the toxic and side effects that western medicine brings, and can effectively improve and alleviate again the rheumatic fever outbreak state of an illness, improve patients ' life quality, clinic promotion and application.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation for the treatment of rheumatic fever, chooses Ramulus Cinnamomi 20 grams, Rhizoma alpiniae chinensis 10 grams, Agkistrodon 10 grams, Fructus Chaenomelis 10 grams, Rhizoma Homalomenae 10 grams, Herba Aristolochiae Mollissimae 10 grams, 10 grams, Semen Armeniacae Amarum, Radix Cyathulae 10 grams, Radix Sophorae Flavescentis 10 grams, Herba Artemisiae Scopariae 8 grams, 8 grams, Flos Carthami, Pericarpium Citri Reticulatae 8 grams, Cortex schizophragmatis integrifolii radicis 8 grams, 8 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 8 grams, Massa Medicata Fermentata 8 grams.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of rheumatic fever, chooses Ramulus Cinnamomi 25 grams, Rhizoma alpiniae chinensis 15 grams, Agkistrodon 15 grams, Fructus Chaenomelis 15 grams, Rhizoma Homalomenae 15 grams, Herba Aristolochiae Mollissimae 15 grams, 15 grams, Semen Armeniacae Amarum, Radix Cyathulae 15 grams, Radix Sophorae Flavescentis 15 grams, Herba Artemisiae Scopariae 12 grams, 10 grams, Flos Carthami, Pericarpium Citri Reticulatae 10 grams, Cortex schizophragmatis integrifolii radicis 10 grams, 10 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 10 grams, Massa Medicata Fermentata 10 grams.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of rheumatic fever, chooses Ramulus Cinnamomi 30 grams, Rhizoma alpiniae chinensis 20 grams, Agkistrodon 20 grams, Fructus Chaenomelis 20 grams, Rhizoma Homalomenae 20 grams, Herba Aristolochiae Mollissimae 20 grams, 20 grams, Semen Armeniacae Amarum, Radix Cyathulae 20 grams, Radix Sophorae Flavescentis 20 grams, Herba Artemisiae Scopariae 15 grams, 12 grams, Flos Carthami, Pericarpium Citri Reticulatae 12 grams, Cortex schizophragmatis integrifolii radicis 12 grams, 12 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 12 grams, Massa Medicata Fermentata 12 grams.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:
Case 1
Zhang, female, 35 years old.Patient's 3 years causes experience cold-damp and onset, and cause brothers' arthralgia to be out of shape, Chinese and western medicine multi-treatment is invalid, is often worth overcast and rainy then acute attack, hurt like hell, it is acute to meet cold rnning, obtains warmly slightly to subtract, Hypomenorrhea, have a large amount of atropurpureus clot, light red tongue is purple, and tongue is slightly thick in vain, deep pulse and unable.Afterwards, under friend recommendation, adopt medicine of the present invention to nurse one's health and administer, patient consumes more than 60 agent, arthralgia disappears substantially, then takes 10 doses in addition after after treatment, Rehabilitation.Follow up a case by regular visits to and have no outbreak half a year.
Claims (4)
1. treat a Chinese medicine preparation for rheumatic fever, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 20-30 gram, Rhizoma alpiniae chinensis 10-20 gram, Agkistrodon 10-20 gram, Fructus Chaenomelis 10-20 gram, Rhizoma Homalomenae 10-20 gram, Herba Aristolochiae Mollissimae 10-20 gram, Semen Armeniacae Amarum 10-20 gram, Radix Cyathulae 10-20 gram, Radix Sophorae Flavescentis 10-20 gram, Herba Artemisiae Scopariae 8-15 gram, Flos Carthami 8-12 gram, Pericarpium Citri Reticulatae 8-12 gram, Cortex schizophragmatis integrifolii radicis 8-12 gram, Radix Rehmanniae Preparata 8-12 gram, Caulis Piperis Kadsurae 8-12 gram, Massa Medicata Fermentata 8-12 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 20 grams, Rhizoma alpiniae chinensis 10 grams, Agkistrodon 10 grams, Fructus Chaenomelis 10 grams, Rhizoma Homalomenae 10 grams, Herba Aristolochiae Mollissimae 10 grams, 10 grams, Semen Armeniacae Amarum, Radix Cyathulae 10 grams, Radix Sophorae Flavescentis 10 grams, Herba Artemisiae Scopariae 8 grams, 8 grams, Flos Carthami, Pericarpium Citri Reticulatae 8 grams, Cortex schizophragmatis integrifolii radicis 8 grams, 8 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 8 grams, Massa Medicata Fermentata 8 grams.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 25 grams, Rhizoma alpiniae chinensis 15 grams, Agkistrodon 15 grams, Fructus Chaenomelis 15 grams, Rhizoma Homalomenae 15 grams, Herba Aristolochiae Mollissimae 15 grams, 15 grams, Semen Armeniacae Amarum, Radix Cyathulae 15 grams, Radix Sophorae Flavescentis 15 grams, Herba Artemisiae Scopariae 12 grams, 10 grams, Flos Carthami, Pericarpium Citri Reticulatae 10 grams, Cortex schizophragmatis integrifolii radicis 10 grams, 10 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 10 grams, Massa Medicata Fermentata 10 grams.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Ramulus Cinnamomi 30 grams, Rhizoma alpiniae chinensis 20 grams, Agkistrodon 20 grams, Fructus Chaenomelis 20 grams, Rhizoma Homalomenae 20 grams, Herba Aristolochiae Mollissimae 20 grams, 20 grams, Semen Armeniacae Amarum, Radix Cyathulae 20 grams, Radix Sophorae Flavescentis 20 grams, Herba Artemisiae Scopariae 15 grams, 12 grams, Flos Carthami, Pericarpium Citri Reticulatae 12 grams, Cortex schizophragmatis integrifolii radicis 12 grams, 12 grams, Radix Rehmanniae Preparata, Caulis Piperis Kadsurae 12 grams, Massa Medicata Fermentata 12 grams.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961435A (en) * | 2009-11-10 | 2011-02-02 | 武晓英 | Rheumatism ostalgia plaster |
| CN104107338A (en) * | 2013-04-17 | 2014-10-22 | 商月波 | Medicated wine for treating rheumatism |
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- 2015-01-07 CN CN201510005743.2A patent/CN104491659A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961435A (en) * | 2009-11-10 | 2011-02-02 | 武晓英 | Rheumatism ostalgia plaster |
| CN104107338A (en) * | 2013-04-17 | 2014-10-22 | 商月波 | Medicated wine for treating rheumatism |
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| 孙元莹等: "张琪教授治疗类风湿性关节炎经验介绍", 《新中医》 * |
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