CN104491385A - Tradtional Chinese medicine health wine - Google Patents

Tradtional Chinese medicine health wine Download PDF

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Publication number
CN104491385A
CN104491385A CN201410717534.6A CN201410717534A CN104491385A CN 104491385 A CN104491385 A CN 104491385A CN 201410717534 A CN201410717534 A CN 201410717534A CN 104491385 A CN104491385 A CN 104491385A
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CN
China
Prior art keywords
parts
wine
chinese medicament
poria
raw material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410717534.6A
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Chinese (zh)
Inventor
严茂伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guizhou Bao Dong Jiang Zang Wine Co Ltd
Original Assignee
Guizhou Bao Dong Jiang Zang Wine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Guizhou Bao Dong Jiang Zang Wine Co Ltd filed Critical Guizhou Bao Dong Jiang Zang Wine Co Ltd
Priority to CN201410717534.6A priority Critical patent/CN104491385A/en
Publication of CN104491385A publication Critical patent/CN104491385A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/586—Turtles; Tortoises, e.g. terrapins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention discloses a tradtional Chinese medicine health wine, consisting of the following raw materials in parts by weight: 17-25 parts of dwarf lilyturf tuber, 13-21 parts of poria cocos, 16-24 parts of citrus chachiensis hortorum, 12-20 parts of cornus pulp, 18-26 parts of wolfberry, 7-15 parts of Szechuan lovage rhizome, 6-14 parts of divaricate saposhnikovia root, 8-16 parts of silica gel and 46-54 parts of kaoliang wine. The health wine is prepared from various purely natural tradtional Chinese medicines; the components exert respective effects and jointly achieve the effects of securing essence and nourishing blood, promoting blood circulation and soothing nerves, relieving fatigue, harmonizing qi and blood and nourishing internal organs; the components are matched with each other to promote self adjustment of physical functions, so that yin and yang of a drinker are harmonious, and the absorption capability is improved; and the health wine has an obvious health effect, and can effectively solve the problems of sleep, alopecia and the like by long-term appropriate drinking.

Description

A kind of Chinese medicament healthcare wine
Technical field
The present invention relates to drinks processing technique field, be specifically related to a kind of Chinese medicament healthcare wine.
Background technology
The meaning of health preserving is then maintenance life.Nourishing by adjusting spirit, diet, reaching the raw body of maintenance, reducing disease, improving health, the activity of life lengthening is all health preserving activity.What health preserving was focused on is basic adjustment, relates to each daily details, to guarantee the sound development of health.In brief, health be body under the protection of external factor, keep the basic operation of normal health, maintenance and guarantee life; Health preserving is then the activity by own beneficial, and the health of let us deacclimatizes natural environment, strengthens the ability resisting various affect, and finally reaches the object of slow down aging.Health preserving wine is vital base and primordial QI consolidating, is the adjustment to function of human body, is applicable to all groups.
The formula of current most health preserving wine, nutrition.Function is different, but these health preserving wines all can occur because in formula, each component collocation is even not, and negative and positive are inharmonious, dependency grow to wine to cause drinking person to occur, health preserving DeGrain, complicated process of preparation, high in cost of production problem.The health preserving wine that market is sold is that producer is in order to cater to the market demand, simply various Chinese herbal medicine is added in wine, do not consider its reasonability completely, and harmony, just by amplification unlimited for medicinal effects, this health preserving wine does not only have health-care effect, even can produce dependence because of long-term drink to this wine, cause health imbalance of YIN and YANG, degradation problem under physical function.
Summary of the invention
For solving the problems of the technologies described above, the invention provides that a kind of health preserving is effective, the simple Chinese medicament healthcare wine of preparation technology.
The present invention is achieved by the following technical programs:
A kind of Chinese medicament healthcare wine, it is made up of following raw material: Radix Ophiopogonis 17-25 part, Poria 13-21 part, Pericarpium citri reticuatae chachiensis 16-24 part, Fructus Corni 12-20 part, Fructus Lycii 18-26 part, Rhizoma Chuanxiong 7-15 part, Radix Saposhnikoviae 6-14 part, Colla Plastri Testudinis 8-16 part, jowar wine 46-54 part.
Described Chinese medicament healthcare wine is made up of following raw material: Radix Ophiopogonis 19-23 part, Poria 15-19 part, Pericarpium citri reticuatae chachiensis 18-22 part, Fructus Corni 14-18 part, Fructus Lycii 20-24 part, Rhizoma Chuanxiong 9-13 part, Radix Saposhnikoviae 8-12 part, Colla Plastri Testudinis 10-14 part, jowar wine 48-52 part.
Described Chinese medicament healthcare wine is made up of following raw material: Radix Ophiopogonis 20-22 part, Poria 16-18 part, Pericarpium citri reticuatae chachiensis 19-21 part, Fructus Corni 15-17 part, Fructus Lycii 21-23 part, Rhizoma Chuanxiong 10-12 part, Radix Saposhnikoviae 9-11 part, Colla Plastri Testudinis 11-13 part, jowar wine 49-51 part.
Described Chinese medicament healthcare wine is made up of following raw material: Radix Ophiopogonis 21 parts, 17 parts, Poria, Pericarpium citri reticuatae chachiensis 20 parts, Fructus Corni 16 parts, Fructus Lycii 22 parts, Rhizoma Chuanxiong 11 parts, Radix Saposhnikoviae 10 parts, Colla Plastri Testudinis 12 parts, jowar wine 50 parts.
Also containing Semen Castaneae 14 parts in described Chinese medicament healthcare wine.
Also containing Semen Allii Tuberosi 7 parts in described Chinese medicament healthcare wine.
Beneficial effect of the present invention is: this health preserving wine is by the traditional Chinese medicine of various pure natural, each component jointly to play that controlling nocturnal emission with astringent drugs nourishes blood while each self-applying, blood-promoting and mind-easing, fatigue alleviating and QI and blood, supports the effect of internal organs playing, each component cooperatively interacts, promote the self regulation of physical function, drinking person negative and positive are coordinated, and absorbability is improved, its health care's successful, drink in right amount for a long time, can the effective problem such as improving water flood and alopecia.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described, but described in claimed scope is not limited to.
Embodiment one
Raw material: Radix Ophiopogonis 17 parts, 13 parts, Poria, Pericarpium citri reticuatae chachiensis 16 parts, Fructus Corni 12 parts, Fructus Lycii 18 parts, Rhizoma Chuanxiong 7 parts, Radix Saposhnikoviae 6 parts, Colla Plastri Testudinis 8 parts, jowar wine 46 parts, Semen Castaneae 14 parts, Semen Allii Tuberosi 7 parts.
Preparation method: through pulverizing part after Radix Ophiopogonis, Poria, Pericarpium citri reticuatae chachiensis, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Semen Castaneae, Semen Allii Tuberosi are cleaned, bind up with gauze, put into jowar wine, seal 68 days up for safekeeping, take out the gauze that raw material is housed, more namely obtain finished product after sealing 12 days up for safekeeping.
Embodiment two
Raw material: Radix Ophiopogonis 25 parts, 21 parts, Poria, Pericarpium citri reticuatae chachiensis 24 parts, Fructus Corni 20 parts, Fructus Lycii 26 parts, Rhizoma Chuanxiong 15 parts, Radix Saposhnikoviae 14 parts, Colla Plastri Testudinis 16 parts, jowar wine 54 parts, Semen Castaneae 14 parts, Semen Allii Tuberosi 7 parts.
Preparation method: through pulverizing part after Radix Ophiopogonis, Poria, Pericarpium citri reticuatae chachiensis, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Semen Castaneae, Semen Allii Tuberosi are cleaned, bind up with gauze, put into jowar wine, seal 68 days up for safekeeping, take out the gauze that raw material is housed, more namely obtain finished product after sealing 12 days up for safekeeping.
Embodiment three
Raw material: Radix Ophiopogonis 19 parts, 15 parts, Poria, Pericarpium citri reticuatae chachiensis 18 parts, Fructus Corni 14 parts, Fructus Lycii 20 parts, Rhizoma Chuanxiong 9 parts, Radix Saposhnikoviae 8 parts, Colla Plastri Testudinis 10 parts, jowar wine 48 parts, Semen Castaneae 14 parts, Semen Allii Tuberosi 7 parts.
Preparation method: through pulverizing part after Radix Ophiopogonis, Poria, Pericarpium citri reticuatae chachiensis, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Semen Castaneae, Semen Allii Tuberosi are cleaned, bind up with gauze, put into jowar wine, seal 68 days up for safekeeping, take out the gauze that raw material is housed, more namely obtain finished product after sealing 12 days up for safekeeping.
Embodiment four
Raw material: Radix Ophiopogonis 23 parts, 19 parts, Poria, Pericarpium citri reticuatae chachiensis 22 parts, Fructus Corni 18 parts, Fructus Lycii 24 parts, Rhizoma Chuanxiong 13 parts, Radix Saposhnikoviae 12 parts, Colla Plastri Testudinis 14 parts, jowar wine 52 parts, Semen Castaneae 14 parts, Semen Allii Tuberosi 7 parts.
Preparation method: through pulverizing part after Radix Ophiopogonis, Poria, Pericarpium citri reticuatae chachiensis, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Semen Castaneae, Semen Allii Tuberosi are cleaned, bind up with gauze, put into jowar wine, seal 68 days up for safekeeping, take out the gauze that raw material is housed, more namely obtain finished product after sealing 12 days up for safekeeping.
Embodiment five
Raw material: Radix Ophiopogonis 20 parts, 16 parts, Poria, Pericarpium citri reticuatae chachiensis 19 parts, Fructus Corni 15 parts, Fructus Lycii 21 parts, Rhizoma Chuanxiong 10 parts, Radix Saposhnikoviae 9 parts, Colla Plastri Testudinis 11 parts, jowar wine 49 parts, Semen Castaneae 14 parts, Semen Allii Tuberosi 7 parts.
Preparation method: through pulverizing part after Radix Ophiopogonis, Poria, Pericarpium citri reticuatae chachiensis, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Semen Castaneae, Semen Allii Tuberosi are cleaned, bind up with gauze, put into jowar wine, seal 68 days up for safekeeping, take out the gauze that raw material is housed, more namely obtain finished product after sealing 12 days up for safekeeping.
Embodiment six
Raw material: Radix Ophiopogonis 22 parts, 18 parts, Poria, Pericarpium citri reticuatae chachiensis 21 parts, Fructus Corni 17 parts, Fructus Lycii 23 parts, Rhizoma Chuanxiong 12 parts, Radix Saposhnikoviae 11 parts, Colla Plastri Testudinis 13 parts, jowar wine 51 parts, Semen Castaneae 14 parts, Semen Allii Tuberosi 7 parts.
Preparation method: through pulverizing part after Radix Ophiopogonis, Poria, Pericarpium citri reticuatae chachiensis, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Semen Castaneae, Semen Allii Tuberosi are cleaned, bind up with gauze, put into jowar wine, seal 68 days up for safekeeping, take out the gauze that raw material is housed, more namely obtain finished product after sealing 12 days up for safekeeping.
Embodiment seven
Raw material: Radix Ophiopogonis 21 parts, 17 parts, Poria, Pericarpium citri reticuatae chachiensis 20 parts, Fructus Corni 16 parts, Fructus Lycii 22 parts, Rhizoma Chuanxiong 11 parts, Radix Saposhnikoviae 10 parts, Colla Plastri Testudinis 12 parts, jowar wine 50 parts, Semen Castaneae 14 parts, Semen Allii Tuberosi 7 parts.
Preparation method: through pulverizing part after Radix Ophiopogonis, Poria, Pericarpium citri reticuatae chachiensis, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Saposhnikoviae, Colla Plastri Testudinis, Semen Castaneae, Semen Allii Tuberosi are cleaned, bind up with gauze, put into jowar wine, seal 68 days up for safekeeping, take out the gauze that raw material is housed, more namely obtain finished product after sealing 12 days up for safekeeping.

Claims (6)

1. a Chinese medicament healthcare wine, is characterized in that: it is made up of following raw material: Radix Ophiopogonis 17-25 part, Poria 13-21 part, Pericarpium citri reticuatae chachiensis 16-24 part, Fructus Corni 12-20 part, Fructus Lycii 18-26 part, Rhizoma Chuanxiong 7-15 part, Radix Saposhnikoviae 6-14 part, Colla Plastri Testudinis 8-16 part, jowar wine 46-54 part.
2. Chinese medicament healthcare wine according to claim 1, is characterized in that: described Chinese medicament healthcare wine is made up of following raw material: Radix Ophiopogonis 19-23 part, Poria 15-19 part, Pericarpium citri reticuatae chachiensis 18-22 part, Fructus Corni 14-18 part, Fructus Lycii 20-24 part, Rhizoma Chuanxiong 9-13 part, Radix Saposhnikoviae 8-12 part, Colla Plastri Testudinis 10-14 part, jowar wine 48-52 part.
3. Chinese medicament healthcare wine according to claim 1, is characterized in that: described Chinese medicament healthcare wine is made up of following raw material: Radix Ophiopogonis 20-22 part, Poria 16-18 part, Pericarpium citri reticuatae chachiensis 19-21 part, Fructus Corni 15-17 part, Fructus Lycii 21-23 part, Rhizoma Chuanxiong 10-12 part, Radix Saposhnikoviae 9-11 part, Colla Plastri Testudinis 11-13 part, jowar wine 49-51 part.
4. Chinese medicament healthcare wine according to claim 1, is characterized in that: described Chinese medicament healthcare wine is made up of following raw material: Radix Ophiopogonis 21 parts, 17 parts, Poria, Pericarpium citri reticuatae chachiensis 20 parts, Fructus Corni 16 parts, Fructus Lycii 22 parts, Rhizoma Chuanxiong 11 parts, Radix Saposhnikoviae 10 parts, Colla Plastri Testudinis 12 parts, jowar wine 50 parts.
5. Chinese medicament healthcare wine according to claim 1, is characterized in that: also containing Semen Castaneae 14 parts in described Chinese medicament healthcare wine.
6. Chinese medicament healthcare wine according to claim 1, is characterized in that: also containing Semen Allii Tuberosi 7 parts in described Chinese medicament healthcare wine.
CN201410717534.6A 2014-12-02 2014-12-02 Tradtional Chinese medicine health wine Pending CN104491385A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106754134A (en) * 2016-12-29 2017-05-31 重庆市嘉利酒业有限公司 Physical fitness healthy medicated wine

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Publication number Priority date Publication date Assignee Title
JP2004033164A (en) * 2002-07-05 2004-02-05 Kiyoko Oyasato Method for producing herb liquor
CN103320274A (en) * 2013-05-19 2013-09-25 杨秀国 Longevity wine and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004033164A (en) * 2002-07-05 2004-02-05 Kiyoko Oyasato Method for producing herb liquor
CN103320274A (en) * 2013-05-19 2013-09-25 杨秀国 Longevity wine and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106754134A (en) * 2016-12-29 2017-05-31 重庆市嘉利酒业有限公司 Physical fitness healthy medicated wine

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Application publication date: 20150408