CN104490905A - Hemorrhoid treatment cream and preparation method thereof - Google Patents

Abstract

The invention discloses a hemorrhoid treatment cream, and relates to the technical field of medicines. The cream is a medicine prepared by using 0.5-1.5g of triamcinolone acetonide, 4-10g of neomycin sulfate, 8-12g of miconazole nitrate, 100-200g of stearic acid, 50-100g of glyceryl stearate, 40-70ml of liquid paraffin, 50-100ml of propylene glycol, 0.1-1ml of azone, 0.5-1.5g of ethylparaben and 500-800ml of distilled water. The hemorrhoid treatment cream accords with the traditional Chinese medicine syndrome differentiation theory in traditional Chinese medicinal material selection and compatibility, and has the advantages of simple preparation method, fast effectiveness, high cure rate and no recurrence.

Description

A kind of emulsifiable paste and preparation method being used for the treatment of hemorrhoid

Technical field

The present invention relates to medical art, be specifically related to a kind of emulsifiable paste and the preparation method that are used for the treatment of hemorrhoid.

Background technology

Hemorrhoid are the distinctive commonly encountered diseases of the mankind, frequently-occurring disease.Show according to relevant reconnaissance information, the sickness rate of anorectal disease is 59.1%, and hemorrhoid account in all anal and intestinal diseases 87.25%, and wherein common with internal hemorrhoid, account for 52.19% of all anal and intestinal diseases.Men and women all can fall ill, and the sickness rate of women is 67%, and the sickness rate of male is 53.9%; Any age all can fall ill, and wherein the people in 20-40 year is comparatively common, and increases the weight of with advancing age and gradually, therefore has saying of " ten people nine hemorrhoid ".Hemorrhoid the lighter made troubles to the orthobiosis of people; Severe one is unhealthful.As having blood in stool with the passing of time, anemia in various degree can be caused, even hemorrhagic shock, threat to life; Hemorrhoid are downright bad, when infecting serious, can be passed through blood system and cause systemic infection, consequence is serious.

Because hemorrhoid are generated by hemorrhoidal veins varicose congestion, and the bacterium such as intestinal is malicious, escherichia coli, staphylococcus aureus, yeast, they interact, make the normal absorption function imbalance of human rectum, system of defense is disorderly, produce inflammation, make rectum, anus raw skin ulcer, redness, pain, proctoptosis, anal fissure etc.Research finds, medical treatment hemorrhoid are mostly with oral or instillation antibiotic, and coordinate external medication, and do not have Tri-Biocin in these external used medicines, focus of cannot going directly, therefore effect is not very good.

Summary of the invention

It is high that technical problem to be solved by this invention is to provide a kind of cure rate, the safe and reliable emulsifiable paste being used for the treatment of hemorrhoid, and success is used for the treatment of hemorrhoid antibiotic and glucocorticoid medicine, and preparation is simple, stable in properties.

Technical problem to be solved by this invention realizes by the following technical solutions:

Be used for the treatment of an emulsifiable paste for hemorrhoid, the medicament formulated by following crude drug: triamcinolone acetonide 0.5-1.5g, polygynax 4-10g, miconazole nitrate 8-12g, stearic acid 100-200g, tristerin 50-100g, liquid paraffin 40-70ml, propylene glycol 50-100ml, azone 0.1-1ml, ethyl hydroxybenzoate 0.5-1.5g, distilled water 500-800ml;

The optimum ratio of each crude drug is: triamcinolone acetonide 1g, polygynax 7g, miconazole nitrate 10g, stearic acid 130g, tristerin 70g, liquid paraffin 50ml, propylene glycol 80ml, azone 0.5ml, ethyl hydroxybenzoate 1g, distilled water (pure water) 650ml;

Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets the national drug standards.

Another object of the present invention is to provide a kind of method preparing above-mentioned emulsifiable paste, comprises the steps,

1) each crude drug is taken by above-mentioned prescription stand-by;

2) by triamcinolone acetonide, polygynax, miconazole nitrate grinds to form powdery, obtains granular material stand-by;

3) get stearic acid, tristerin, liquid paraffin puts into container, heating in water bath, and temperature controls at 70-80 DEG C, stirs and is molten into oily mater, stand-by;

4) another taking ethylparaben and propylene glycol stir, and add in the lump in the distilled water of 70-80 DEG C, stir, obtain aqueous mixture in azone, stand-by;

5) by step 3) in oily mater slowly add step 4) in aqueous mixture in, do not stop stir, when temperature is down to 60 DEG C, add step 2) in granular material, stir.

Pharmacology analysis:

Triamcinolone acetonide: sugar skin hormone class medicine, white crystalline powder, odorless, have antipruritic, antiinflammatory, anti-allergic effects; Treatment anus redness, sufferings etc. are used as in we.

Polygynax: white powder, has antibacterial action to gram-bacteria races such as yeast; Antiinflammatory, antibacterial action is made in we, effective to bacterium such as intestinal poison, staphylococcus aureuses;

Miconazole nitrate: white crystalline powder, odorless, have antifungic action.

Stearic acid: the glossiness wax-like small pieces of white, soft, nontoxic, be a kind of higher unsaturated fatty acid, in we, make emulsifying agent, inserts.

Tristerin: white or pale waxy solid, have the fat note of smelling good, make emulsifying agent, lubricant in we.

Liquid paraffin: colourless viscous liquid, odorless, tasteless, make emulsifying agent.

Propylene glycol: colourless transparent liquid, has hygroscopicity, does to inhale smelly, lubrication in we.

Azone: oiliness colourless transparent liquid, we make penetrating agent and help medicine to enter focus very soon.

Ethyl hydroxybenzoate: white crystalline powder, has slight fragrance, bitter in the mouth, to photosynthetic thermally-stabilised, make antibacterial, antisepsis, be dissolved in propylene glycol in we.

Distilled water: diluent in we.

Usage and consumption:

Every day is cleaned after an action of the bowels, and medication about 1 gram, sends in anus, once a day; Umbilicus is massaged into absorption a little, every day 2 times.

Points for attention:

1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.

2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.

3. driver, work high above the ground person are cautious use of.

4. strictly take by usage and dosage, this medicine should not be taken for a long time in a large number.

5. pair this medicine and alcohol intolerance person forbidding, allergic constitution person be cautious use of.

6. prohibit the use when this property of drug changes.

7. please this medicine is placed on the place that child can not contact.

8. as used other medicines, please Ref Dr or pharmacist before using this medicine.

Diagnostic criteria

Associated therapy situation of the present invention is as follows:

1. physical data

Now for clinical 100 routine hemorrhoid patients, wherein man 45 example, age 18-70 year, female 55 example, age 20-60 year.

2. diagnostic criteria

Mixed hemorrhoids: dyschesia, has falling inflation sense, having a rest property of defecation time band blood, bleeds or sprays blood, and blood stasis is deviate from.

3. Therapeutic Method:

Using method: every day is cleaned after an action of the bowels, with emulsifiable paste of the present invention about 1 gram, sends in anus, once a day; Umbilicus is got a little emulsifiable paste and is massaged into absorption, every day 2 times.

4. efficacy assessment standard

Effective:

Stool is normal, without falling inflation sense, and depletion of blood during defecation; Medication onset after 2 hours, 24 hours transference cures.

Take a turn for the better:

Stool is normal, without falling inflation sense, and depletion of blood during defecation; 24 hours transference cures;

Invalid:

Dyschesia, has falling inflation sense, having a rest property of defecation time band blood, bleeds or sprays blood, and blood stasis is deviate from;

5. therapeutic outcome (see table 1)

Table 1 is observation of curative effect after treatment

Disease example	Case load	Effective	Take a turn for the better	Invalid	Effective percentage
						Mixed hemorrhoids	100	98	2	0	100％

Result shows there are 98 example recoveries from illness in 100 routine patients, and cure rate is 98%, and relapse rate comparatively other medicines reduces by 80%, and comparatively other medicines treat fast 3-5 days.

The invention has the beneficial effects as follows: the present invention selects at Chinese crude drug and compatibility meets Chinese medical discrimination theory, and compound method simply, and have rapid-action, cure rate is high, not easily the advantage such as recurrence.

Detailed description of the invention

The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.

Embodiment 1

Be used for the treatment of an emulsifiable paste for hemorrhoid, the medicament formulated by following crude drug: triamcinolone acetonide 1g, polygynax 7g, miconazole nitrate 10g, stearic acid 130g, tristerin 70g, liquid paraffin 50ml, propylene glycol 80ml, azone 0.5ml, ethyl hydroxybenzoate 1g, distilled water 650ml;

Preparation method is as follows:

1) each crude drug is taken by above-mentioned prescription stand-by;

2) by triamcinolone acetonide, polygynax, miconazole nitrate grinds to form powdery, obtains granular material stand-by;

3) get stearic acid, tristerin, liquid paraffin puts into container, heating in water bath, and temperature controls at 70-80 DEG C, stirs and is molten into oily mater, stand-by;

4) another taking ethylparaben and propylene glycol stir, and add in the lump in the distilled water of 70-80 DEG C, stir, obtain aqueous mixture in azone, stand-by;

5) by step 3) in oily mater slowly add step 4) in aqueous mixture in, do not stop stir, when temperature is down to 60 DEG C, add step 2) in granular material, stir.

Every day is cleaned after an action of the bowels, with emulsifiable paste of the present invention about 1 gram, sends in anus, once a day; Umbilicus is got a little emulsifiable paste and is massaged into absorption, every day 2 times.Mixed hemorrhoids medication onset after 2 hours, 24 hours transference cures, consolidate one week cure rate and reach 100%; Anal fistula patient uses 20 days continuously, and silt block reduces and disappears, and cure rate reaches 98%.

Embodiment 2

Be used for the treatment of an emulsifiable paste for hemorrhoid, the medicament formulated by following crude drug: triamcinolone acetonide 0.8g, polygynax 8g, miconazole nitrate 9g, stearic acid 120g, tristerin 80g, liquid paraffin 60ml, propylene glycol 70ml, azone 0.6ml, ethyl hydroxybenzoate 0.9g, distilled water 600ml;

Preparation method is as follows:

1) each crude drug is taken by above-mentioned prescription stand-by;

2) by triamcinolone acetonide, polygynax, miconazole nitrate grinds to form powdery, obtains granular material stand-by;

3) get stearic acid, tristerin, liquid paraffin puts into container, heating in water bath, and temperature controls at 70-80 DEG C, stirs and is molten into oily mater, stand-by;

4) another taking ethylparaben and propylene glycol stir, and add in the lump in the distilled water of 70-80 DEG C, stir, obtain aqueous mixture in azone, stand-by;

5) by step 3) in oily mater slowly add step 4) in aqueous mixture in, do not stop stir, when temperature is down to 60 DEG C, add step 2) in granular material, stir.

Every day is cleaned after an action of the bowels, with emulsifiable paste of the present invention about 1 gram, sends in anus, once a day; Umbilicus is got a little emulsifiable paste and is massaged into absorption, every day 2 times.Mixed hemorrhoids medication onset after 2 hours, 24 hours transference cures, consolidate one week cure rate and reach 100%; Anal fistula patient uses 20 days continuously, and silt block reduces and disappears, and cure rate reaches 98%.

Embodiment 3

Be used for the treatment of an emulsifiable paste for hemorrhoid, the medicament formulated by following crude drug: triamcinolone acetonide 1.2g, polygynax 8g, miconazole nitrate 12g, stearic acid 110g, tristerin 75g, liquid paraffin 55ml, propylene glycol 85ml, azone 1ml, ethyl hydroxybenzoate 1.2g, pure water 700ml;

Preparation method is as follows:

1) each crude drug is taken by above-mentioned prescription stand-by;

2) by triamcinolone acetonide, polygynax, miconazole nitrate grinds to form powdery, obtains granular material stand-by;

3) get stearic acid, tristerin, liquid paraffin puts into container, heating in water bath, and temperature controls at 70-80 DEG C, stirs and is molten into oily mater, stand-by;

4) another taking ethylparaben and propylene glycol stir, and add in the lump in the pure water of 70-80 DEG C, stir, obtain aqueous mixture in azone, stand-by;

5) by step 3) in oily mater slowly add step 4) in aqueous mixture in, do not stop stir, when temperature is down to 60 DEG C, add step 2) in granular material, stir.

Every day is cleaned after an action of the bowels, with emulsifiable paste of the present invention about 1 gram, sends in anus, once a day; Umbilicus is got a little emulsifiable paste and is massaged into absorption, every day 2 times.Mixed hemorrhoids medication onset after 2 hours, 24 hours transference cures, consolidate one week cure rate and reach 100%; Anal fistula patient uses 20 days continuously, and silt block reduces and disappears, and cure rate reaches 98%.

Facts have proved, this medicine is made lotion and easily runs off; Make suppository, patch has limitation, make emulsifiable paste ideal, easy to use, not easily run off, long action time.Emulsifiable paste processed will select the materials such as lubrication, anticorrosion, infiltration in addition, as substrate, can bear leading medicine, can also play auxiliary therapeutic action.The present invention is with reference to human-body safety dosage, and plus-minus makes emulsifiable paste in proportion, and result of the test display effect is obvious especially, and after 2 hours, symptom alleviates, 24 hours transference cures.

Model case:

Korea Spro so-and-so, man, 52 years old, Fuyang City environmental sanitation place staff.Suffer from hemorrhoid more than 10 year, belong to heavier inside and outside hemorrhoid, have blood in stool, can not sit time serious, hurt like hell, used various patch, lotion, endo-medicine etc., fail to fully recover.Use emulsifiable paste of the present invention 3 days, stopping of suppurating of bleeding, after using 20 days continuously, blood stasis diminishes, and does not recur after healing always.

Lee so-and-so, man, 45 years old, Fuyang City civil servant.Suffered from internal hemorrhoid in 2008, be hard and dry always, sometimes have blood in stool, pain, did Repeated Operation, eaten multiple medicine and to have helped still multiple relapse: adopted emulsifiable paste of the present invention, continuously treatment after 20 days symptom all disappear, do not recur so far.

Grandson so-and-so, man, 21 years old, people from Jieshou City, Anhui, student.Suffered from external hemorrhoid in 2010, be hard and dry, pain due to hemorrhoid, can not attend class.Adopt emulsifiable paste of the present invention, transference cure, consolidated use and cured for 2 weeks, and paid a return visit several times, do not recur so far the same day.

More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (3)

1. one kind is used for the treatment of the emulsifiable paste of hemorrhoid, it is characterized in that, the medicament formulated by following crude drug: triamcinolone acetonide 0.5-1.5g, polygynax 4-10g, miconazole nitrate 8-12g, stearic acid 100-200g, tristerin 50-100g, liquid paraffin 40-70ml, propylene glycol 50-100ml, azone 0.1-1ml, ethyl hydroxybenzoate 0.5-1.5g, distilled water 500-800ml.

2. a kind of emulsifiable paste being used for the treatment of hemorrhoid according to claim 1, it is characterized in that, the medicament formulated by following crude drug: triamcinolone acetonide 1g, polygynax 7g, miconazole nitrate 10g, stearic acid 130g, tristerin 70g, liquid paraffin 50ml, propylene glycol 80ml, azone 0.5ml, ethyl hydroxybenzoate 1g, distilled water 650ml.

3. prepare a method for emulsifiable paste described in claim 1 or 2, it is characterized in that, comprise the following steps,

1) each crude drug is taken by above-mentioned prescription stand-by;

2) by triamcinolone acetonide, polygynax, miconazole nitrate grinds to form powdery, obtains granular material stand-by;

3) get stearic acid, tristerin, liquid paraffin puts into container, heating in water bath, and temperature controls at 70-80 DEG C, stirs and is molten into oily mater, stand-by;

4) another taking ethylparaben and propylene glycol stir, and add in the lump in the distilled water of 70-80 DEG C, stir, obtain aqueous mixture in azone, stand-by;

5) by step 3) in oily mater slowly add step 4) in aqueous mixture in, do not stop stir, when temperature is down to 60 DEG C, add step 2) in granular material, stir.