CN104485835A - Biocompatible miniature frictional generator - Google Patents
Biocompatible miniature frictional generator Download PDFInfo
- Publication number
- CN104485835A CN104485835A CN201410728985.XA CN201410728985A CN104485835A CN 104485835 A CN104485835 A CN 104485835A CN 201410728985 A CN201410728985 A CN 201410728985A CN 104485835 A CN104485835 A CN 104485835A
- Authority
- CN
- China
- Prior art keywords
- miniature
- generator
- sheet material
- ethyl cellulose
- knifing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a biocompatible miniature frictional generator. The biocompatible miniature frictional generator consists of an upper pole plate nylon 66 coating layer, an upper pole plate poly-L-lactic acid macromolecule pair frictional layer, a lower pole plate ethyl cellulose pair frictional layer and a lower pole plate nylon 66 coating layer, wherein an upper pole plate material is an insulation type plate material formed by poly-L-lactic acid, and electrons are easily obtained; a lower pole plate is an insulation type plate material formed by ethyl cellulose, and electrons are easily lost; patterns in different shapes are manufactured on contact interfaces of the upper and lower pole plates, the upper and lower pole plates are in tight contact in a concave-convex opposite manner to form an arc-shaped space, and the space is packaged by a biocompatible nylon 66 film. The biocompatible miniature frictional generator has the advantages that the miniature generator is simple in structure, small in size and easy to operate; after the generator is inserted in vivo, micro voltage and micro current are generated by extrusion friction such as organism exercise, external massage and vibration; the generator can serve as a power supply of miniature diagnosis and treatment equipment implanted in vivo, and is widely applied to the medical fields of diagnosis, quick treatment, organ regeneration and the like.
Description
Technical field
The present invention relates to micro generation technology mechanical energy being become electric energy, particularly a kind of biocompatibility miniature friction generator.
Background technology
Electrostatic charging is a kind of very ancient phenomenon, can trace back to B.C. centuries, and Greeks and ancient Chinese find can be attracted small and light object by the amber rubbed.But the randomness produced due to it and storage problem, make it to be regarded as the useless energy, and can not develop always.In recent years, along with the progress of material preparation technology, collect and the energy of " useless " in storage environment, the energy making it to become miniaturized electronics becomes possibility.The concept of the friction electricity nano generator that georgia ,u.s.a Institute of Technology professor Wang Zhonglin proposes, for alleviating energy crisis provides a new approach.
Institutes Of Technology Of Tianjin Chen Min virtue teach problem group is devoted to the research and discovery of the good biomaterial of biocompatibility for many years always, in these years old teacher seminar achieves great successes in this respect, corresponding problem is had in magnesium alloy, titanium alloy, medical high polymer PLA, particularly in degradable biomaterial research, achieve gratifying achievement especially.Just based on this overall situation, the seminar of old teacher, at the beginning of learning friction nanometer power generator, just takes the lead in proposing the concept of the good friction nanometer power generator of biocompatibility.In a lot of medical events, also need the energy, such as cardiac pacemaker, but traditional battery can not provide permanent electric energy, so often bring many inconvenience to patient.How effectively solving similar problem, the electric energy furnishing us with needs that both can be permanent, that lets slip no opportunity again is compatible in vivo, and this is a problem of benefiting the whole mankind, provides new thinking for we solve Similar Problems.
In years of researches, we understand the important meaning of biocompatible materials for patient clearly, more particularly there is the macromolecular material of extensively approval, the PLA such as, mentioned in this example and ethyl cellulose, as traditional bioabsorbable polymer material, good dielectricity is absolutely necessary, and therefore first we contemplate this bi-material in an experiment.
Summary of the invention
The present invention is directed to technical Analysis above, there is provided a kind of delivery efficiency high, workable and the biocompatibility miniature friction generator that can use in practice, this miniature friction generator realizes driving vivo and vitro miniature friction generator, the object that acceleration bodies inner tissue repairs.
Technical scheme of the present invention:
A kind of biocompatibility miniature friction generator, by top crown nylon66 fiber coating layer, top crown PLLA macromolecule is to frictional layer, infrabasal plate ethyl cellulose is to frictional layer and bottom crown nylon66 fiber coating layer composition, top crown material is easily obtain the shaping sheet material of the insulated type PLLA of electronics, bottom crown is the shaping sheet material of the insulated type ethyl cellulose of volatile de-electromation, on, the contact interface of bottom crown is manufactured with difform floral designs, on, bottom crown forms arc space according to concavo-convex relative close contact, and adopt the nylon66 fiber thin-film package of biocompatibility.
The molecular weight of described top crown material PLLA is 8-15 ten thousand, and the thickness of top crown material is 2-4mm, width is 40-60mm, length is 60-70mm, and adopt knifing machine preparation, concrete steps comprise:
1) bio-medical PLLA particle is placed in organic solvent dichloromethane according to the ratio that mass ratio is 1:5-7, heats and stir at 40-60 DEG C, until the colloid that color is homogeneous can be being seen;
2) scrape at film-laying machine and place masking foil above lamina membranacea and pave, plastic film mulch room vacuumizes, vacuum degree is 0.07-0.09MPa, and then poured in knifing machine by homogeneous PLLA colloid and carry out knifing, the thickness of controlling diaphragm is 2-4 mm, length, width all >=100mm, controlling knifing machine temperature is 40 DEG C, and insulation 2h, takes out sheet material, being cut into width is 40-60mm, and length is that the sheet material of 60-70mm is stand-by.
The molecular weight of described bottom crown Materials Ethylcellulose is 80-150 ten thousand, and bottom crown material thickness is 2-4mm, and adopt knifing machine preparation, concrete steps comprise:
1) bio-medical ethyl cellulose crude granule is placed according to the ratio that mass ratio is 1:5-1:7 the organic solvent that ethylene glycol mixes with ethanol, in mixed organic solvents, the volume ratio of ethylene glycol and ethanol is respectively 4:1,5:1,2:1, stir at 40-60 DEG C, until the colloid that color is homogeneous can be seen;
2) scrape at film-laying machine and place masking foil above lamina membranacea and pave, plastic film mulch room vacuumizes, vacuum degree is 0.07-0.09MPa, and then poured in knifing machine by homogeneous ethyl cellulose colloid and carry out knifing, the thickness of controlling diaphragm is 2-4mm, length, width all >=100mm, controlling knifing machine temperature is 40 DEG C, and insulation 2h, takes out sheet material, being cut into width is 40-60mm, and length is that the sheet material of 60-70mm is stand-by.
The concavo-convex individual shapes of the contact interface floral designs of described upper and lower pole plate is triangular prism, cylinder, circular cone, pyramid or round platform, and its length three-dimensional dimension is respectively 1-10 μm, 1-10 μm, 1-100 μm; The macromolecule organic sheet material sheared adopts pressure sintering, magnetron sputtering or ion etching to obtain by the preparation method of floral designs.
Advantage of the present invention is:
Should based on the biocompatibility microgenerator of friction effect, structure is simple, volume is little, simple to operate, insert after in body, move through human body, external massage, the extrusion frictions such as vibrations, produce micro voltage, electric current, namely microgenerator is formed, can be used as the miniature diagnosis implanted, the power supply of therapeutic equipment, also damage location can be directly acted on, moved or external massage by human body, vibrations wait the micro voltage of extrusion friction generation and cell are grown fast, and then damaged tissues is fully recovered fast, diagnosis can be widely used in, the medical domain such as fast treating and neomorph.This microgenerator is connected with damaged tissues, provides high voltage low current, can Promote cell's growth, has the effect accelerating organization healing.
[accompanying drawing explanation]
Fig. 1 PLLA and ethyl cellulose are the biological friction electric generator structural representation of upper and lower base plate.
In figure: 1. top crown nylon66 fiber coating layer, 2. top crown PLLA macromolecule to frictional layer, 3. infrabasal plate ethyl cellulose to frictional layer, 4. bottom crown nylon66 fiber coating layer.
[embodiment]
Instantiation illustrated is below intended to understand objective purposes of the present invention in detail and understand intuitively to make reader have.In addition should be understood that those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after the content of having read the present invention's instruction.
Embodiment 1:
A kind of biocompatibility miniature friction generator, as shown in Figure 1, by top crown nylon66 fiber coating layer 1, top crown PLLA macromolecule is to frictional layer 2, infrabasal plate ethyl cellulose forms frictional layer 3 and bottom crown nylon66 fiber coating layer 4, top crown material is easily obtain the shaping sheet material of the insulated type PLLA of electronics, bottom crown is the shaping sheet material of the insulated type ethyl cellulose of volatile de-electromation, on, the contact interface of bottom crown is manufactured with difform floral designs, on, bottom crown forms arc space according to concavo-convex relative close contact, and adopt the nylon66 fiber thin-film package of biocompatibility.
The molecular weight of described top crown material PLLA is 150,000, and the thickness of top crown material is 4mm, width is 60mm, length is 70mm, and adopt knifing machine preparation, concrete steps comprise:
Bio-medical PLLA particle is placed in organic solvent dichloromethane according to the ratio that mass ratio is 1:5, heats and stir at 40 DEG C, until the colloid that color is homogeneous can be being seen; Scrape at film-laying machine and place masking foil above lamina membranacea and pave, plastic film mulch room vacuumizes, vacuum degree is 0.07MPa, and then poured in knifing machine by homogeneous PLLA colloid and carry out knifing, the thickness of controlling diaphragm is 4 mm, length, width are 100mm, controlling knifing machine temperature is 40 DEG C, and insulation 2h, takes out sheet material, being cut into width is 60mm, and length is that the sheet material of 70mm is stand-by.
The molecular weight of described bottom crown Materials Ethylcellulose is 800,000, and bottom crown material thickness is 4mm, and adopt knifing machine preparation, concrete steps comprise:
Bio-medical ethyl cellulose crude granule is placed according to the ratio that mass ratio is 1:5 the organic solvent that ethylene glycol mixes with ethanol, in mixed organic solvents, the volume ratio of ethylene glycol and ethanol is respectively 5:1, stir at 60 DEG C, until the colloid that color is homogeneous can be seen; Scrape at film-laying machine and place masking foil above lamina membranacea and pave, plastic film mulch room vacuumizes, vacuum degree is 0.09MPa, and then poured in knifing machine by homogeneous ethyl cellulose colloid and carry out knifing, the thickness of controlling diaphragm is 4mm, length, width are 100mm, controlling knifing machine temperature is 40 DEG C, and insulation 2h, takes out sheet material, being cut into width is 460mm, and length is that the sheet material of 70mm is stand-by; Concrete grammar is:
The concavo-convex individual shapes of the contact interface floral designs of described upper and lower pole plate is cylinder, and its diameter is 4 μm, is highly 10 μm; The macromolecule organic sheet material sheared adopts pressure sintering to obtain by the preparation method of floral designs, and concrete grammar is:
Cut the 3000 object steel wires purchased, the complete macromolecule sheet material of ensuring coverage, arranging hot press temperature is 80 DEG C, and pressure is 8.0 × 10
6n/M
2, hot pressing 5min, can see regular micro-pattern after hot pressing under an optical microscope.
The assembling of friction generator: upper and lower base plate is taked elastic bonding, encapsulate with polyimides adhesive plaster, elastic space surplus is left in centre, two-plate takes contact separation formula friction mode, requires to have corresponding modulus of elasticity, toughness to friction material, rigidity, freely can reply, control turnaround time at 3ms, good experiment effect could be obtained.
The detection of friction generator: oscilloscope, power supply preamplifier, friction nanometer power generator that voltage preamplifier is good with the biocompatibility made are connected, carry out the measurements and calculations of output current, voltage, electric energy and power.This miniature friction generator is inserted after in body, through extrusion frictions such as human body motion, external massage, vibrations, produces micro voltage, electric current.Found by test, the crest voltage of output is 150V, and peak current is 9 μ A.
Claims (4)
1. a biocompatibility miniature friction generator, it is characterized in that: by top crown nylon66 fiber coating layer, top crown PLLA macromolecule is to frictional layer, infrabasal plate ethyl cellulose is to frictional layer and bottom crown nylon66 fiber coating layer composition, top crown material is easily obtain the shaping sheet material of the insulated type PLLA of electronics, bottom crown is the shaping sheet material of the insulated type ethyl cellulose of volatile de-electromation, on, the contact interface of bottom crown is manufactured with difform floral designs, on, bottom crown forms arc space according to concavo-convex relative close contact, and adopt the nylon66 fiber thin-film package of biocompatibility.
2. biocompatibility miniature friction generator according to claim 1, it is characterized in that: the molecular weight of described top crown material PLLA is 8-15 ten thousand, the thickness of top crown material is 2-4mm, width is 40-60mm, length is 60-70mm, and adopt knifing machine preparation, concrete steps comprise:
1) bio-medical PLLA particle is placed in organic solvent dichloromethane according to the ratio that mass ratio is 1:5-7, heats and stir at 40-60 DEG C, until the colloid that color is homogeneous can be being seen;
2) scrape at film-laying machine and place masking foil above lamina membranacea and pave, plastic film mulch room vacuumizes, vacuum degree is 0.07-0.09MPa, and then poured in knifing machine by homogeneous PLLA colloid and carry out knifing, the thickness of controlling diaphragm is 2-4 mm, length, width all >=100mm, controlling knifing machine temperature is 40 DEG C, and insulation 2h, takes out sheet material, being cut into width is 40-60mm, and length is that the sheet material of 60-70mm is stand-by.
3. biocompatibility miniature friction generator according to claim 1, is characterized in that: the molecular weight of described bottom crown Materials Ethylcellulose is 80-150 ten thousand, and bottom crown material thickness is 2-4mm, and adopt knifing machine preparation, concrete steps comprise:
1) bio-medical ethyl cellulose crude granule is placed according to the ratio that mass ratio is 1:5-1:7 the organic solvent that ethylene glycol mixes with ethanol, in mixed organic solvents, the volume ratio of ethylene glycol and ethanol is respectively 4:1,5:1,2:1, stir at 40-60 DEG C, until the colloid that color is homogeneous can be seen;
2) scrape at film-laying machine and place masking foil above lamina membranacea and pave, plastic film mulch room vacuumizes, vacuum degree is 0.07-0.09MPa, and then poured in knifing machine by homogeneous ethyl cellulose colloid and carry out knifing, the thickness of controlling diaphragm is 2-4mm, length, width all >=100mm, controlling knifing machine temperature is 40 DEG C, and insulation 2h, takes out sheet material, being cut into width is 40-60mm, and length is that the sheet material of 60-70mm is stand-by.
4. biocompatibility miniature friction generator according to claim 1, it is characterized in that: the concavo-convex individual shapes of the contact interface floral designs of described upper and lower pole plate is triangular prism, cylinder, circular cone, pyramid or round platform, its length three-dimensional dimension is respectively 1-10 μm, 1-10 μm, 1-100 μm; The macromolecule organic sheet material sheared adopts pressure sintering, magnetron sputtering or ion etching to obtain by the preparation method of floral designs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410728985.XA CN104485835B (en) | 2014-12-05 | 2014-12-05 | A kind of biocompatibility miniature friction electromotor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410728985.XA CN104485835B (en) | 2014-12-05 | 2014-12-05 | A kind of biocompatibility miniature friction electromotor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104485835A true CN104485835A (en) | 2015-04-01 |
| CN104485835B CN104485835B (en) | 2016-11-16 |
Family
ID=52760352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410728985.XA Expired - Fee Related CN104485835B (en) | 2014-12-05 | 2014-12-05 | A kind of biocompatibility miniature friction electromotor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104485835B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106026759A (en) * | 2016-05-20 | 2016-10-12 | 北京科技大学 | Transient dissoluble friction electric generator and preparation method thereof |
| CN107959437A (en) * | 2017-12-21 | 2018-04-24 | 浙江大学 | The high performance grinding nano generator of paper substrate |
| CN108649832A (en) * | 2018-05-11 | 2018-10-12 | 浙江大学 | Contact-type frictional power generator based on suspended type vibration |
| CN109603004A (en) * | 2018-12-04 | 2019-04-12 | 苏州大学 | It is a kind of to drive electric stimulation, sticking plaster and inhibition of cancer cell capsule certainly |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102684546A (en) * | 2012-05-15 | 2012-09-19 | 纳米新能源（唐山）有限责任公司 | Friction generator |
| CN102710166A (en) * | 2012-04-13 | 2012-10-03 | 纳米新能源（唐山）有限责任公司 | Friction generator |
| CN103107732A (en) * | 2013-01-30 | 2013-05-15 | 天津理工大学 | Organism medical disposable micro friction motor and manufacture method thereof |
| CN203663246U (en) * | 2014-01-16 | 2014-06-25 | 国家纳米科学中心 | Heart pacemaker |
| US20140300248A1 (en) * | 2012-09-21 | 2014-10-09 | Georgia Tech Research Corporation | Single Electrode Triboelectric Generator |
-
2014
- 2014-12-05 CN CN201410728985.XA patent/CN104485835B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102710166A (en) * | 2012-04-13 | 2012-10-03 | 纳米新能源（唐山）有限责任公司 | Friction generator |
| CN102684546A (en) * | 2012-05-15 | 2012-09-19 | 纳米新能源（唐山）有限责任公司 | Friction generator |
| US20140300248A1 (en) * | 2012-09-21 | 2014-10-09 | Georgia Tech Research Corporation | Single Electrode Triboelectric Generator |
| CN103107732A (en) * | 2013-01-30 | 2013-05-15 | 天津理工大学 | Organism medical disposable micro friction motor and manufacture method thereof |
| CN203663246U (en) * | 2014-01-16 | 2014-06-25 | 国家纳米科学中心 | Heart pacemaker |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106026759A (en) * | 2016-05-20 | 2016-10-12 | 北京科技大学 | Transient dissoluble friction electric generator and preparation method thereof |
| CN107959437A (en) * | 2017-12-21 | 2018-04-24 | 浙江大学 | The high performance grinding nano generator of paper substrate |
| CN108649832A (en) * | 2018-05-11 | 2018-10-12 | 浙江大学 | Contact-type frictional power generator based on suspended type vibration |
| CN109603004A (en) * | 2018-12-04 | 2019-04-12 | 苏州大学 | It is a kind of to drive electric stimulation, sticking plaster and inhibition of cancer cell capsule certainly |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104485835B (en) | 2016-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | Photothermally tunable biodegradation of implantable triboelectric nanogenerators for tissue repairing | |
| Guo et al. | Self-powered electrical stimulation for enhancing neural differentiation of mesenchymal stem cells on graphene–poly (3, 4-ethylenedioxythiophene) hybrid microfibers | |
| Long et al. | Wearable and implantable electroceuticals for therapeutic electrostimulations | |
| Li et al. | Direct powering a real cardiac pacemaker by natural energy of a heartbeat | |
| CN103107732B (en) | Organism medical disposable micro friction motor and manufacture method thereof | |
| Wang et al. | Applications of nanogenerators for biomedical engineering and healthcare systems | |
| CN104485835A (en) | Biocompatible miniature frictional generator | |
| Li et al. | Culturing primary human osteoblasts on electrospun poly (lactic-co-glycolic acid) and poly (lactic-co-glycolic acid)/nanohydroxyapatite scaffolds for bone tissue engineering | |
| Huang et al. | Implantable electronic medicine enabled by bioresorbable microneedles for wireless electrotherapy and drug delivery | |
| CN107800323A (en) | A kind of full degradable nano generator of natural material | |
| CN107961420B (en) | Self-driven medicine injection device and injection method | |
| JP2005537909A5 (en) | ||
| WO2010005915A3 (en) | Energy harvesting for implanted medical devices | |
| Rui et al. | Parylene-based implantable Pt-black coated flexible 3-D hemispherical microelectrode arrays for improved neural interfaces | |
| Luo et al. | Biomimetic approaches toward smart bio-hybrid systems | |
| Martinelli et al. | Wet adhesion of buckypaper produced from oxidized multiwalled carbon nanotubes on soft animal tissue | |
| Liang et al. | Piezotronic effect determined neuron-like differentiation of adult stem cells driven by ultrasound | |
| Yang et al. | Engineering a wirelessly self-powered and electroconductive scaffold to promote peripheral nerve regeneration | |
| Xia et al. | Electrical stimulation enabled via electrospun piezoelectric polymeric nanofibers for tissue regeneration | |
| Zhao et al. | Recent progress of nanogenerators acting as self‐powered drug delivery devices | |
| Luo et al. | Nonadjacent wireless electrotherapy for tissue repair by a 3D-printed bioresorbable fully soft triboelectric nanogenerator | |
| Wang et al. | Triboelectric nanogenerators-based therapeutic electrical stimulation on skin: From fundamentals to advanced applications | |
| WO2022048028A1 (en) | Electret facial mask for promoting absorption of phytoestrogen, and production method therefor | |
| Chung et al. | An implantable battery system for a continuous automatic distraction device for mandibular distraction osteogenesis | |
| CN110420344A (en) | A kind of wound dressing and the preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161116 Termination date: 20181205 |