CN104479150A - Preparation method of multiple cross-linked polysaccharide injectable hydrogel - Google Patents
Preparation method of multiple cross-linked polysaccharide injectable hydrogel Download PDFInfo
- Publication number
- CN104479150A CN104479150A CN201410589982.2A CN201410589982A CN104479150A CN 104479150 A CN104479150 A CN 104479150A CN 201410589982 A CN201410589982 A CN 201410589982A CN 104479150 A CN104479150 A CN 104479150A
- Authority
- CN
- China
- Prior art keywords
- chitosan
- polysaccharide
- multiple cross
- aqueous solution
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of multiple cross-linked polysaccharide injectable hydrogel. Modified water-soluble chitosan with carboxyl or hydroxyl groups as a first component and a hydroformylation-modified polysaccharide polymer or polysaccharide polymer mixer as a second component produce electrostatic action with each other and undergo a Schiff-base reaction to produce the hydrogel with a multiple cross-linked net structure. The multiple cross-linked polysaccharide injectable hydrogel has gelling time of 5-200s and has good mechanical properties. Through change of a chitosan and polysaccharide modification rate, a mole ratio of two components and solid content of hydrogel, gelling time, mechanical strength, microscopic morphology and water content are adjusted and controlled. The gel network contains a large amount of amino, carboxyl and aldehyde groups as active groups, the active groups can be bonded to drugs and proteins by covalent bonds, the multiple cross-linked polysaccharide injectable hydrogel as a novel medical material with excellent biocompatibility has a good application prospect in the fields of regeneration medical science, tissue engineering and drug controlled release.
Description
Technical field
The present invention relates to a kind of hydrogel preparation method, particularly injectable hydrogel preparation method, be applied to the technical fields such as regenerative medicine, organizational project, medicine controlled releasing.
Background technology
Hydrogel is hydrophilic polymer network, and it can absorb a large amount of moisture, but can not be dissolved in the water due to the physical crosslinking between polymer chain and chemically crosslinked effect, can only swelling and keep certain shape.Hydrogel has good biocompatibility, water permeate, can be obtained the hydrogel material of diverse microcosmic stuctures and properties by synthetic, and these character make hydrogel obtain a wide range of applications at biomedical sector.In regenerative medicine field, the research of injection aquagel is especially noticeable.Injection aquagel can be used for bioactive molecules controlled release, cell embedding and be used as the aspect such as tissue stent material.Hydrogel in vivo original position is formed, and the height in surgical procedures so just can be avoided traumatic, healing acceleration, minimizing patient misery, reduction medical expense.Especially when being used for repairing the organizing of complicated shape, injection aquagel has adaptivity, and can solidify by body temperature, this is that general hydrogel is incomparable.Can say, injection aquagel is one of important directions of future biological medical material application development.
Injection aquagel can be divided into physical cross-linking hydrogel and chemically crosslinked aquagel by formation mechenism.The molecular chain of physical cross-linking hydrogel is connected by non covalent bond, as some time valency power effects such as model ylid bloom action, ionization, hydrogen bond action and hydrophobic interaction the cross-linked structure that formed, and these hydrogels generally can by phase co-conversion between sol-gel state.But physical crosslinking reactive force is more weak, easily destroyed when the ambient conditions such as pH value, ionic strength changes, mechanical property is poor, therefore is subject to certain restrictions in practical application.Chemically crosslinked aquagel then makes molecular chain form three-dimensional cross-linked network structure by covalent linkage effect by linking agent, performance comparatively physical cross-linking hydrogel is stablized, there is higher cross-linking density and good mechanical property, and can by degree of crosslinking and the swelling capacity regulating the consumption of linking agent to control gel.But chemically crosslinked aquagel uses the low molecule linking agent or the properties-correcting agent that there are certain toxic side effect, inevitably brings biocompatibility issues.
The material source of injection aquagel is mainly divided into synthesis and natural polymer.The latter comprises protein and polysaccharide, and have the similar biochemical structure of extracellular matrix and composition, good biocompatibility, cheap, material source is extensive.Chitosan is a kind of natural aminoglucose glycopolymers, and positively charged, its structure is similar to polysaccharide in the base of extracellular, and degraded product is in vivo glucosamine monomer, can absorb by human body.In addition, chitosan also has good biocompatibility, has no adverse reaction to tissue, and wide material sources, low price, is widely used in organizational project.Due in its molecule, intermolecular hydrogen bond action, make it be crystalline structure closely, so water insoluble and most of organic solvent.The poorly soluble principal element becoming the application of restriction chitosan.
Summary of the invention
In order to solve prior art problem, the object of the invention is to the deficiency overcoming prior art existence, a kind of multiple cross-linked polysaccharide injectable hydrogel preparation method is provided, take chitosan as main ingredient, using polyose polymer or polyose macromolecule mixture as second component, modification is carried out to two components, obtains good mechanical property, biocompatibility by schiff base reaction and electrostatic interaction good and can the multiple cross-linked hydrogel of injectable chitosan of rapid shaping.The present invention carries out water-soluble modified to chitosan, can be applied to the injection aquagel system of low cost and safety.
Create object for reaching foregoing invention, the present invention adopts following technical proposals:
A kind of multiple cross-linked polysaccharide injectable hydrogel preparation method, there is the water-soluble chitosan of carboxylic group or oh group after chemical modification as the first component, using the polyose polymer carrying out aldehyde radical chemical modification or carry out aldehyde radical chemical modification polyose macromolecule mixture as second component, by the electrostatic interaction between the component of two kinds of modifications and schiff base reaction, obtain the hydrogel with multiple cross-linked network structure.
As the preferred technical scheme of the present invention, the aldehyde grouping modified polysaccharide solution of preparation quality concentration to be the modified chitosan aqueous solution of 0.5 ~ 3wt% and mass concentration be 0.5 ~ 3wt% respectively, respectively as the first component and second component, by two components with volume ratio 9:1 ~ 1:9 mixing, by the electrostatic interaction between the component of two kinds of modifications and schiff base reaction, obtain the hydrogel with multiple cross-linked network structure.
As the technical scheme that the present invention is more preferably, with hydroxyl acids properties-correcting agent or anhydrides properties-correcting agent, chemical modification is carried out to chitosan, obtain the water-soluble chitosan with carboxylic group or oh group, hydroxyl acids properties-correcting agent adopts oxyacetic acid, lactic acid or lactobionic acid, and anhydrides properties-correcting agent adopts Succinic anhydried, Pyroglutaric acid or adipic anhydride.
As the first preferred version of technique scheme, preparation mass percent concentration is the chitosan aqueous solution of 0.1 ~ 1wt%, by properties-correcting agent and chitosan repeating unit mol ratio 0.5:1 ~ 6:1, add hydroxyl acids properties-correcting agent in chitosan aqueous solution after, be that being added in above-mentioned solution of 0.5:1 ~ 3:1 is dissolved by N-hydroxy-succinamide or I-hydroxybenzotriazole and chitosan repeating unit mol ratio, regulator solution pH is 4 ~ 7, add activator 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride, be 0.5:1 ~ 5:1 according to 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride and N-hydroxy-succinamide mol ratio, activator is added chitosan aqueous solution system.Make chitosan aqueous solution system react carry out 1 ~ 48h after, the pH value of chitosan aqueous solution system is adjusted to 7, then product dialysis freeze-drying, namely obtain through the acrylic modified water-soluble chitosan with oh group of hydroxyl.N-hydroxy-succinamide or I-hydroxybenzotriazole are not hydroxyl acids properties-correcting agent, are a kind of secondary activation agents, are used as supplementing of activator 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride, play a part to improve activation efficiency.
As the second preferred version of technique scheme, preparation mass percent concentration is the chitosan aqueous solution of 0.1 ~ 1wt%, by properties-correcting agent and chitosan repeating unit mol ratio 0.5:1 ~ 6:1, anhydrides properties-correcting agent is added in chitosan aqueous solution, make chitosan aqueous solution system react carry out 10 ~ 48h after product acetone precipitation, the pH value of chitosan aqueous solution system is adjusted to 7, and freeze-drying of then being dialysed by product, namely obtains the water-soluble chitosan with oh group through anhydrides modification.
As the preferred version of technique scheme, adopt oxygenant, polysaccharide repeating unit being contained to adjacent hydroxyl or adjacent hydroxyl groups/amino carries out oxidation modification, obtains aldehyde grouping modified polysaccharide derivates.
Scheme is more preferably as technique scheme, preparation mass percent concentration is the polyose water-soluble polymers of 0.1 ~ 1wt%, add oxygenant, oxygenant and polysaccharide polymer repeating unit mol ratio are 0.1:1 ~ 1:1, react 1 ~ 5h under lucifuge condition after, then add ethylene glycol in polyose water-soluble polymers system, ethylene glycol and oxygenant mol ratio are 1:1 ~ 2:1, then modified product to be dialysed freeze-drying, namely obtain aldehyde grouping modified polysaccharide derivates.
Above-mentioned oxygenant preferably adopts sodium periodate, potassium bichromate, hydrogen peroxide or S-WAT.
Above-mentioned polyose polymer preferably adopts cm-chitosan, hyaluronic acid, carboxymethyl cellulose or sodium alginate.
The present invention compared with prior art, has following apparent outstanding substantive distinguishing features and remarkable advantage:
1. the present invention is directed to the defect of chemically crosslinked aquagel and physical cross-linking hydrogel, prepare the injection aquagel based on electrostatic interaction and schiff bases chemically crosslinked, chemical modification is carried out to chitosan, introduce carboxyl, the groups such as hydroxyl, prepare the water-soluble chitosan dissolved in neutral conditions, metal carboxylate polysaccharide is carried out partial oxidation process, obtain aldehyde radical polysaccharide derivates, by the electrostatic interaction in the schiff base reaction between the aldehyde radical on the amino on modified chitosan and aldehyde radical polysaccharide derivates and amino and polysaccharide between carboxyl, successfully prepare chitosan injection aquagel,
2. the hydrogel that prepared by the present invention effectively can avoid the use of small molecules linking agent, improves the biocompatibility of hydrogel, can strengthen stability and the physical strength of single effect hydrogel simultaneously;
3. the injection aquagel gelation time prepared of the present invention is between 5 ~ 200s, adopt multiple cross-linked one-tenth adhesive process, make this hydrogel have good mechanical property, can be regulated and controled gelation time, mechanical strength, microscopic appearance, water content by the solid content changing chitosan and the degree of modification of polysaccharide, the mol ratio of two components and hydrogel;
4. a large amount of amino, carboxyl, the aldehyde radical isoreactivity group that contain of the gel network inside of the hydrogel prepared of the present invention, can by covalent linkage and medicine and protein binding;
5. the hydrogel prepared of the present invention is as the excellent new medical material of a kind of novel biocompatibility, has good application prospect in fields such as organizational project, medicine controlled releasing, regenerative medicines.
Embodiment
Details are as follows for the preferred embodiments of the present invention:
embodiment one:
In the present embodiment, a kind of multiple cross-linked polysaccharide injectable hydrogel preparation method, its preparation process is as follows:
Take 0.3g chitosan, be dissolved in 100ml water, add 0.264mL lactic acid, after complete stirring and dissolving, add
n-N-Hydroxysuccinimide 0.424g, regulates pH to 4.8,1-ethyl-(3-dimethylaminopropyl) phosphinylidyne diimmonium salt hydrochlorate 1.411g, and reaction 36h, is transferred to 7.0 by pH.Product dialysis freeze-drying; Taking Lalgine 2.5g joins in the water of 50mL, stirring and dissolving in a water bath, until completely dissolved, adds sodium periodate 1.08g, under lucifuge condition, reacts 3h, adds 600 μ L ethylene glycol termination reactions.Product dialysis freeze-drying.Respectively modified chitosan and Lalgine are mixed with the aqueous solution of 0.5wt%, equal-volume mixes, and obtain hydrogel after 156s, storage modulus is 132 pa.
The present embodiment has the hydrogel of multiple cross-linked structure by electrostatic interaction and schiff bases chemically crosslinked preparation, and gives its good mechanical property.Can be regulated and controled gelation time, mechanical strength, microscopic appearance, water content by the solid content changing chitosan and the degree of modification of another fraction polysaccharide, the mol ratio of two components and hydrogel.Gel network a large amount of amino of containing of inside and aldehyde radical isoreactivity group can by covalent linkage and medicine and protein binding.
embodiment two:
The present embodiment is substantially identical with embodiment one, and special feature is:
In the present embodiment, take 0.3g chitosan, be dissolved in 100mL water, add 0.132mL oxyacetic acid, progressively drip after a certain amount of hydrochloric acid to chitosan dissolves completely, add
n-N-Hydroxysuccinimide 0.424g, regulates pH to 4.7,1-ethyl-(3-dimethylaminopropyl) phosphinylidyne diimmonium salt hydrochlorate 1.411g, after reaction 48h, pH is transferred to 7.0.Product dialysis freeze-drying; Taking hyaluronate sodium 2.5g joins in the water of 50mL, stirring and dissolving in a water bath, until completely dissolved, adds sodium periodate 1.08g, under lucifuge condition, reacts 4h, adds 600 μ L ethylene glycol termination reactions.Product dialysis freeze-drying.Respectively modified chitosan and hyaluronate sodium are mixed with the aqueous solution of 1wt%, equal-volume mixes, and obtain hydrogel after 70s, storage modulus is 257 pa.
embodiment three:
The present embodiment and previous embodiment are substantially identical, and special feature is:
In the present embodiment, take 0.3g chitosan, be dissolved in 100mL water, add 0.132mL lactic acid, progressively drip after a certain amount of hydrochloric acid to chitosan dissolves completely, add
n-N-Hydroxysuccinimide 0.636g, regulates pH to 4.7,1-ethyl-(3-dimethylaminopropyl) phosphinylidyne diimmonium salt hydrochlorate 2.116g, after reaction 48h, pH is transferred to 7.0.Product dialysis freeze-drying; Taking cm-chitosan 2.5g joins in the water of 50mL, stirring and dissolving in a water bath, until completely dissolved, adds sodium periodate 1.08g, under lucifuge condition, reacts 3h, adds 600 μ L ethylene glycol termination reactions.Product filters, acetone sedimentation, then dissolves dialysis freeze-drying.Respectively two kinds of modified chitosan are made the aqueous solution of 1wt%, equal-volume mixes, and obtain hydrogel after 113s, storage modulus is 195 pa.
embodiment four:
The present embodiment and previous embodiment are substantially identical, and special feature is:
In the present embodiment, take 0.3g chitosan, be dissolved in 100mL aqueous acetic acid, the mass concentration 1wt% of aqueous acetic acid, add 0.6738mL Succinic anhydried, reaction 24h, then pH is transferred to 7.0.Product filters, dialysis freeze-drying; Taking carboxymethyl cellulose 2.5g joins in the water of 50mL, stirring and dissolving in a water bath, until completely dissolved, adds sodium periodate 1.62g, under lucifuge condition, reacts 1h, adds 800 μ L ethylene glycol termination reactions.Product dialysis freeze-drying.Respectively modified chitosan and carboxymethyl cellulose are mixed with the aqueous solution of 3wt%, equal-volume mixes, and obtain hydrogel after 18s, storage modulus is 1528 pa.
embodiment five:
The present embodiment and previous embodiment are substantially identical, and special feature is:
In the present embodiment, take 0.3g chitosan, be dissolved in 100mL water, add 0.132mL lactic acid, progressively drip after a certain amount of hydrochloric acid to chitosan dissolves completely, add
n-N-Hydroxysuccinimide 0.636g, regulates pH to 4.7,1-ethyl-(3-dimethylaminopropyl) phosphinylidyne diimmonium salt hydrochlorate 2.116g, reaction 48h, then pH is transferred to 7.0.Product filters, dialysis freeze-drying; Taking sodium alginate 2.5g joins in the water of 50mL, stirring and dissolving in a water bath, until completely dissolved, adds sodium periodate 1.08g, under lucifuge condition, reacts 1h, adds 600 μ L ethylene glycol termination reactions.Product dialysis freeze-drying.Respectively modified chitosan and sodium alginate are mixed with the aqueous solution of 2.5wt%, mix, obtain hydrogel after 65s with volume 2:8, storage modulus is 912 pa.
The invention is not restricted to above-described embodiment; multiple change can also be made according to the object of innovation and creation of the present invention; change, the modification made under all spirit according to technical solution of the present invention and principle, substitute, combination, to simplify; all should be the substitute mode of equivalence; as long as goal of the invention according to the invention; only otherwise deviate from know-why and the inventive concept of the present invention's multiple cross-linked polysaccharide injectable hydrogel preparation method, all protection scope of the present invention is belonged to.
Claims (9)
1. a multiple cross-linked polysaccharide injectable hydrogel preparation method, it is characterized in that: there is the water-soluble chitosan of carboxylic group or oh group after chemical modification as the first component, using the polyose polymer carrying out aldehyde radical chemical modification or carry out aldehyde radical chemical modification polyose macromolecule mixture as second component, by the electrostatic interaction between the component of two kinds of modifications and schiff base reaction, obtain the hydrogel with multiple cross-linked network structure.
2. multiple cross-linked polysaccharide injectable hydrogel preparation method according to claim 1, it is characterized in that: the aldehyde grouping modified polysaccharide solution of preparation quality concentration to be the modified chitosan aqueous solution of 0.5 ~ 3wt% and mass concentration be 0.5 ~ 3wt% respectively, respectively as the first component and second component, by two components with volume ratio 9:1 ~ 1:9 mixing, by the electrostatic interaction between the component of two kinds of modifications and schiff base reaction, obtain the hydrogel with multiple cross-linked network structure.
3. multiple cross-linked polysaccharide injectable hydrogel preparation method according to claim 2, it is characterized in that: with hydroxyl acids properties-correcting agent or anhydrides properties-correcting agent, chemical modification is carried out to chitosan, obtain the water-soluble chitosan with carboxylic group or oh group, hydroxyl acids properties-correcting agent adopts oxyacetic acid, lactic acid or lactobionic acid, and anhydrides properties-correcting agent adopts Succinic anhydried, Pyroglutaric acid or adipic anhydride.
4. multiple cross-linked polysaccharide injectable hydrogel preparation method according to claim 3, it is characterized in that: preparation mass percent concentration is the chitosan aqueous solution of 0.1 ~ 1wt%, by properties-correcting agent and chitosan repeating unit mol ratio 0.5:1 ~ 6:1, add hydroxyl acids properties-correcting agent in chitosan aqueous solution after, be that being added in above-mentioned solution of 0.5:1 ~ 3:1 is dissolved by N-hydroxy-succinamide or I-hydroxybenzotriazole and chitosan repeating unit mol ratio, regulator solution pH is 4 ~ 7, add activator 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride, be 0.5:1 ~ 5:1 according to 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride and N-hydroxy-succinamide mol ratio, activator is added chitosan aqueous solution system, make chitosan aqueous solution system react carry out 1 ~ 48h after, the pH value of chitosan aqueous solution system is adjusted to 7, then product dialysis freeze-drying, namely obtain through the acrylic modified water-soluble chitosan with oh group of hydroxyl.
5. multiple cross-linked polysaccharide injectable hydrogel preparation method according to claim 3, it is characterized in that: preparation mass percent concentration is the chitosan aqueous solution of 0.1 ~ 1wt%, by properties-correcting agent and chitosan repeating unit mol ratio 0.5:1 ~ 6:1, anhydrides properties-correcting agent is added in chitosan aqueous solution, make chitosan aqueous solution system react carry out 10 ~ 48h after product acetone precipitation, the pH value of chitosan aqueous solution system is adjusted to 7, then product to be dialysed freeze-drying, namely obtain the water-soluble chitosan with oh group through anhydrides modification.
6. according to multiple cross-linked polysaccharide injectable hydrogel preparation method described in any one in claim 1 ~ 5, it is characterized in that: adopt oxygenant, polysaccharide repeating unit being contained to adjacent hydroxyl or adjacent hydroxyl groups/amino carries out oxidation modification, obtains aldehyde grouping modified polysaccharide derivates.
7. multiple cross-linked polysaccharide injectable hydrogel preparation method according to claim 6, it is characterized in that: preparation mass percent concentration is the polyose water-soluble polymers of 0.1 ~ 1wt%, add oxygenant, oxygenant and polysaccharide polymer repeating unit mol ratio are 0.1:1 ~ 1:1, react 1 ~ 5h under lucifuge condition after, ethylene glycol is added again in polyose water-soluble polymers system, ethylene glycol and oxygenant mol ratio are 1:1 ~ 2:1, then modified product to be dialysed freeze-drying, namely obtain aldehyde grouping modified polysaccharide derivates.
8. multiple cross-linked polysaccharide injectable hydrogel preparation method according to claim 6, is characterized in that: described oxygenant adopts sodium periodate, potassium bichromate, hydrogen peroxide or S-WAT.
9., according to multiple cross-linked polysaccharide injectable hydrogel preparation method described in any one in claim 1 ~ 8, it is characterized in that: described polyose polymer is cm-chitosan, hyaluronic acid, carboxymethyl cellulose or sodium alginate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410589982.2A CN104479150A (en) | 2014-10-29 | 2014-10-29 | Preparation method of multiple cross-linked polysaccharide injectable hydrogel |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410589982.2A CN104479150A (en) | 2014-10-29 | 2014-10-29 | Preparation method of multiple cross-linked polysaccharide injectable hydrogel |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104479150A true CN104479150A (en) | 2015-04-01 |
Family
ID=52753765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410589982.2A Pending CN104479150A (en) | 2014-10-29 | 2014-10-29 | Preparation method of multiple cross-linked polysaccharide injectable hydrogel |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104479150A (en) |
Cited By (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105327388A (en) * | 2015-12-07 | 2016-02-17 | 莫秀梅 | Medical adhesives and preparation method thereof |
CN105770998A (en) * | 2016-03-08 | 2016-07-20 | 兰州理工大学 | Preparation method for multifunctional hydrogel used for 3D printing |
CN105884927A (en) * | 2016-06-22 | 2016-08-24 | 四川师范大学 | Preparation method of polyaldehyde konjac glucomannan cross-linking agent |
CN106344951A (en) * | 2016-07-26 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Hemostatic anti-adhesion bio-membrane and preparation method thereof |
CN106693048A (en) * | 2017-02-23 | 2017-05-24 | 苏州睿研纳米医学科技有限公司 | Dual-computer injectable in-situ functional hydrogel biomaterial and preparation method thereof |
CN106822989A (en) * | 2017-03-29 | 2017-06-13 | 青岛辰达生物科技有限公司 | It is a kind of to promote sprayable gel of wound healing and preparation method thereof |
CN106822911A (en) * | 2016-10-20 | 2017-06-13 | 华东师范大学 | A kind of antibiosis hydrogel of controlled release and its preparation method and application |
CN107242997A (en) * | 2017-05-08 | 2017-10-13 | 同济大学 | A kind of gel rubber material efficiently treated for tumour and preparation method thereof |
CN107252501A (en) * | 2017-04-13 | 2017-10-17 | 广州贝奥吉因生物科技有限公司 | A kind of composite aquogel support for loading sanguinarine/gelatine microsphere and its preparation method and application |
CN107412151A (en) * | 2017-07-25 | 2017-12-01 | 中山大学 | A kind of phytolectin polysaccharide hydrogel of intelligent control insulin releasing and its preparation and application |
CN107417801A (en) * | 2017-06-20 | 2017-12-01 | 中国人民解放军南京军区南京总医院 | A kind of injection aquagel and preparation method and application |
CN107814981A (en) * | 2017-11-09 | 2018-03-20 | 四川艾医生医疗科技有限公司 | A kind of aquagel dressing and preparation method thereof |
CN107964105A (en) * | 2017-11-08 | 2018-04-27 | 福州大学 | A kind of preparation method by the crosslinked polysaccharide based aquagel of dynamic imine linkage |
CN108003391A (en) * | 2017-12-01 | 2018-05-08 | 武汉理工大学 | A kind of full polysaccharide derivates base superabsorbent hydrogel and its preparation method and application |
CN108014376A (en) * | 2017-11-20 | 2018-05-11 | 华南理工大学 | A kind of polysaccharide hydrogel of the base-modified chitosan of beet and preparation method thereof |
CN108404221A (en) * | 2018-04-09 | 2018-08-17 | 郑州轻工业学院 | A kind of syringeability organosilicon/chitosan nano composite hydrogel and the preparation method and application thereof |
CN108671271A (en) * | 2018-04-27 | 2018-10-19 | 东南大学 | A kind of preparation method of anti-adhesion medical gel composite patch |
CN108841011A (en) * | 2018-06-13 | 2018-11-20 | 福建农林大学 | A kind of nano-cellulose self-healing material and preparation method thereof |
CN109157669A (en) * | 2018-09-18 | 2019-01-08 | 东华大学 | Cellulose enhances glucan base injectable anti-bacterial hydrogel dressing and preparation method thereof |
CN109694484A (en) * | 2017-10-20 | 2019-04-30 | 四川大学华西医院 | A kind of immunologic adjuvant and preparation method thereof |
CN109718395A (en) * | 2019-02-28 | 2019-05-07 | 上海交通大学 | Based on the polysaccharide polymer injection aquagel and preparation method of dynamic imine linkage and application |
CN109734937A (en) * | 2019-01-08 | 2019-05-10 | 乐国平 | The preparation method of VA@PLGA-CS-HA/OHPMC-HA antibacterial injection aquagel |
CN109939260A (en) * | 2019-03-01 | 2019-06-28 | 昆明理工大学 | A kind of preparation method of medical chitosan/Sodium Hyaluronate coupling hydrogel |
CN110201219A (en) * | 2019-05-14 | 2019-09-06 | 浙江理工大学 | A kind of composite hydrogel and preparation method thereof of injectable and quick-gelatinizing |
CN110199996A (en) * | 2019-05-10 | 2019-09-06 | 金华市呗力水产养殖技术有限公司 | A kind of preparation method of aquaculture fungicide |
CN110464871A (en) * | 2019-08-21 | 2019-11-19 | 南开大学 | A kind of injection aquagel and preparation method thereof |
CN110498936A (en) * | 2019-07-15 | 2019-11-26 | 北京化工大学 | A kind of preparation method of Sodium Hyaluronate/sodium alginate injection-type composite hydrogel |
CN110540678A (en) * | 2018-05-29 | 2019-12-06 | 怡诺博(北京)生物医学技术有限公司 | Modified sodium alginate hydrogel, cell culture matrix material prepared from same and application of cell culture matrix material |
CN110628090A (en) * | 2019-10-17 | 2019-12-31 | 陕西科技大学 | Cationic guar gum/chitosan composite hydrogel and preparation method thereof |
CN111228212A (en) * | 2020-01-16 | 2020-06-05 | 中国人民解放军军事科学院军事医学研究院 | Drug-loaded injectable implantation in-situ hydrogel |
CN111269332A (en) * | 2020-03-27 | 2020-06-12 | 广州古泉生物科技有限公司 | Preparation and application of chitosan-sodium alginate hydrogel |
CN111303459A (en) * | 2020-01-20 | 2020-06-19 | 华南理工大学 | Preparation method of hyaluronic acid based double-crosslinked hydrogel |
CN111333878A (en) * | 2019-05-23 | 2020-06-26 | 吾奇生物医疗科技(镇江)有限公司 | Double-crosslinked chitosan hydrogel and preparation method and application thereof |
CN111388755A (en) * | 2020-03-20 | 2020-07-10 | 东华大学 | Injectable hyaluronic acid/chitosan hydrogel and preparation method thereof |
CN111410753A (en) * | 2020-03-27 | 2020-07-14 | 西南大学 | Novel chitosan hydrogel and preparation method and application thereof |
CN111471193A (en) * | 2020-06-15 | 2020-07-31 | 四川大学 | Dialdehyde polysaccharide nanoparticle crosslinked collagen hydrogel and preparation method thereof |
CN111518289A (en) * | 2020-05-21 | 2020-08-11 | 山东大学 | Injectable self-healing hydrogel with adjustable mechanical properties and preparation method and application thereof |
CN111662464A (en) * | 2020-07-23 | 2020-09-15 | 南京工业大学 | Preparation method of chitosan/sodium alginate double-network hydrogel |
CN111704729A (en) * | 2020-07-02 | 2020-09-25 | 安徽省立医院(中国科学技术大学附属第一医院) | Hydrogel cell scaffold based on natural polymers and adjustable in strength and gelling time |
CN111803707A (en) * | 2020-06-05 | 2020-10-23 | 上海大学 | Polysaccharide-based fiber composite in-situ pore-forming injectable hydrogel and preparation method thereof |
CN111909396A (en) * | 2020-07-21 | 2020-11-10 | 华南农业大学 | Natural polymer-based supramolecular self-healing hydrogel and preparation method and application thereof |
CN112043874A (en) * | 2020-09-21 | 2020-12-08 | 四川大学 | Three-phase hydrogel and preparation method and application thereof |
WO2021007899A1 (en) * | 2019-07-15 | 2021-01-21 | 浙江工业大学 | Injectable hydrogel material and preparation method therefor and use thereof |
CN112386695A (en) * | 2020-11-30 | 2021-02-23 | 西安交通大学 | Chitosan-based nano prodrug carrying indocyanine green and platinum drugs and preparation method thereof |
CN112646202A (en) * | 2020-11-27 | 2021-04-13 | 北京大学口腔医学院 | Functionalized double-network hydrogel and preparation method and application thereof |
CN112675355A (en) * | 2020-12-16 | 2021-04-20 | 北京大清生物技术股份有限公司 | Degradable medical hydrogel material and preparation method and application thereof |
CN112843325A (en) * | 2021-01-20 | 2021-05-28 | 江苏德威兰医疗器械股份有限公司 | Medical hydrogel adhesive and preparation method and application thereof |
CN112851983A (en) * | 2020-12-31 | 2021-05-28 | 东华大学 | Electrostatic spraying film of hydrogel and preparation method and application thereof |
CN112920428A (en) * | 2021-01-27 | 2021-06-08 | 陈勇 | Composite hydrogel and preparation method thereof |
CN112940291A (en) * | 2021-02-05 | 2021-06-11 | 中国科学技术大学 | Transparent hydrogel based on chitosan and preparation method thereof |
CN113024847A (en) * | 2021-03-19 | 2021-06-25 | 中国科学院宁波材料技术与工程研究所 | Application of natural polysaccharide hydrogel in hemostasis field |
CN113152091A (en) * | 2021-04-21 | 2021-07-23 | 东华大学 | Polysaccharide-based hydrogel-based fabric for visually detecting escherichia coli and pH response and preparation method thereof |
CN113262198A (en) * | 2021-05-27 | 2021-08-17 | 江南大学 | Microgel and preparation method and application thereof |
CN113318276A (en) * | 2021-03-29 | 2021-08-31 | 中山大学附属第一医院 | Preparation method of multiple-crosslinking injectable hydrogel and preparation method and application thereof |
CN113603905A (en) * | 2021-08-24 | 2021-11-05 | 日照武汉理工大生物医药暨新材料研究院 | Adhesive hydrogel and preparation method thereof |
CN113956507A (en) * | 2021-09-27 | 2022-01-21 | 中国科学院宁波材料技术与工程研究所 | Injectable hydrogel and preparation method and application thereof |
CN114230812A (en) * | 2021-12-07 | 2022-03-25 | 广东省科学院健康医学研究所 | Functional hydrogel and preparation method and application thereof |
CN114366756A (en) * | 2021-12-16 | 2022-04-19 | 佑道(天津)健康咨询有限公司 | Crosslinked chitosan hydrogel gastric filler and preparation method and application thereof |
CN114432494A (en) * | 2022-01-12 | 2022-05-06 | 宁波市第一医院 | Sanchinin-loaded hydrogel and preparation method thereof |
CN114712550A (en) * | 2022-04-20 | 2022-07-08 | 华中科技大学 | Hydrogel adhesive capable of being injected for rapid hemostasis and preparation method and application thereof |
CN114762736A (en) * | 2021-01-13 | 2022-07-19 | 中国科学院宁波材料技术与工程研究所慈溪生物医学工程研究所 | Ionic liquid modified chitosan hydrogel and preparation method and application thereof |
CN114796620A (en) * | 2022-04-24 | 2022-07-29 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Interpenetrating network hydrogel used as medical implant material and preparation method and application thereof |
CN114848509A (en) * | 2022-05-24 | 2022-08-05 | 上海家化联合股份有限公司 | Polysaccharide-based gel containing polyhydroxy acids and uses thereof |
CN115010958A (en) * | 2022-05-13 | 2022-09-06 | 楼天女 | Hydrogel for promoting wound healing and preparation method and application thereof |
CN115463622A (en) * | 2022-08-03 | 2022-12-13 | 广东纤友朵美生物科技有限公司 | Gel based on oxidized pectin and preparation method thereof |
CN115746412A (en) * | 2022-10-25 | 2023-03-07 | 南方科技大学 | Water-soluble chitosan composite hydrogel and preparation method and application thereof |
CN117285726A (en) * | 2022-06-16 | 2023-12-26 | 上海其胜生物制剂有限公司 | Injection type dynamic chitosan hydrogel and preparation method and application thereof |
-
2014
- 2014-10-29 CN CN201410589982.2A patent/CN104479150A/en active Pending
Non-Patent Citations (1)
Title |
---|
樊李红: "羟丙基壳聚糖/氧化海藻酸钠水凝胶的制备及表征", 《武汉大学学报(理学版)》 * |
Cited By (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105327388A (en) * | 2015-12-07 | 2016-02-17 | 莫秀梅 | Medical adhesives and preparation method thereof |
CN105770998A (en) * | 2016-03-08 | 2016-07-20 | 兰州理工大学 | Preparation method for multifunctional hydrogel used for 3D printing |
CN105770998B (en) * | 2016-03-08 | 2019-11-22 | 兰州理工大学 | The preparation method of multifunctional water gel for 3D printing |
CN105884927A (en) * | 2016-06-22 | 2016-08-24 | 四川师范大学 | Preparation method of polyaldehyde konjac glucomannan cross-linking agent |
CN106344951A (en) * | 2016-07-26 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Hemostatic anti-adhesion bio-membrane and preparation method thereof |
CN106344951B (en) * | 2016-07-26 | 2019-04-19 | 青岛琛蓝海洋生物工程有限公司 | A kind of bleeding stopping and adherence preventing biomembrane and preparation method thereof |
CN106822911A (en) * | 2016-10-20 | 2017-06-13 | 华东师范大学 | A kind of antibiosis hydrogel of controlled release and its preparation method and application |
CN106693048A (en) * | 2017-02-23 | 2017-05-24 | 苏州睿研纳米医学科技有限公司 | Dual-computer injectable in-situ functional hydrogel biomaterial and preparation method thereof |
CN106822989A (en) * | 2017-03-29 | 2017-06-13 | 青岛辰达生物科技有限公司 | It is a kind of to promote sprayable gel of wound healing and preparation method thereof |
CN107252501A (en) * | 2017-04-13 | 2017-10-17 | 广州贝奥吉因生物科技有限公司 | A kind of composite aquogel support for loading sanguinarine/gelatine microsphere and its preparation method and application |
CN107242997A (en) * | 2017-05-08 | 2017-10-13 | 同济大学 | A kind of gel rubber material efficiently treated for tumour and preparation method thereof |
CN107417801B (en) * | 2017-06-20 | 2020-11-24 | 中国人民解放军东部战区总医院 | Injectable hydrogel and preparation method and application thereof |
CN107417801A (en) * | 2017-06-20 | 2017-12-01 | 中国人民解放军南京军区南京总医院 | A kind of injection aquagel and preparation method and application |
WO2018232856A1 (en) * | 2017-06-20 | 2018-12-27 | 中国人民解放军南京军区南京总医院 | Injectable hydrogel and preparation method and use thereof |
CN107412151A (en) * | 2017-07-25 | 2017-12-01 | 中山大学 | A kind of phytolectin polysaccharide hydrogel of intelligent control insulin releasing and its preparation and application |
CN107412151B (en) * | 2017-07-25 | 2021-04-02 | 中山大学 | Phytohemagglutinin-polysaccharide hydrogel capable of intelligently regulating and controlling insulin release as well as preparation and application thereof |
CN109694484A (en) * | 2017-10-20 | 2019-04-30 | 四川大学华西医院 | A kind of immunologic adjuvant and preparation method thereof |
CN109694484B (en) * | 2017-10-20 | 2021-08-27 | 四川大学华西医院 | Immunologic adjuvant and preparation method thereof |
CN107964105A (en) * | 2017-11-08 | 2018-04-27 | 福州大学 | A kind of preparation method by the crosslinked polysaccharide based aquagel of dynamic imine linkage |
CN107814981A (en) * | 2017-11-09 | 2018-03-20 | 四川艾医生医疗科技有限公司 | A kind of aquagel dressing and preparation method thereof |
CN108014376A (en) * | 2017-11-20 | 2018-05-11 | 华南理工大学 | A kind of polysaccharide hydrogel of the base-modified chitosan of beet and preparation method thereof |
CN108003391A (en) * | 2017-12-01 | 2018-05-08 | 武汉理工大学 | A kind of full polysaccharide derivates base superabsorbent hydrogel and its preparation method and application |
CN108404221A (en) * | 2018-04-09 | 2018-08-17 | 郑州轻工业学院 | A kind of syringeability organosilicon/chitosan nano composite hydrogel and the preparation method and application thereof |
CN108671271A (en) * | 2018-04-27 | 2018-10-19 | 东南大学 | A kind of preparation method of anti-adhesion medical gel composite patch |
CN108671271B (en) * | 2018-04-27 | 2020-12-25 | 东南大学 | Preparation method of anti-adhesion medical gel composite patch |
CN110540678A (en) * | 2018-05-29 | 2019-12-06 | 怡诺博(北京)生物医学技术有限公司 | Modified sodium alginate hydrogel, cell culture matrix material prepared from same and application of cell culture matrix material |
CN110540678B (en) * | 2018-05-29 | 2022-09-06 | 怡诺博(北京)生物医学技术有限公司 | Modified sodium alginate hydrogel, cell culture matrix material prepared from same and application of cell culture matrix material |
CN108841011A (en) * | 2018-06-13 | 2018-11-20 | 福建农林大学 | A kind of nano-cellulose self-healing material and preparation method thereof |
CN109157669B (en) * | 2018-09-18 | 2021-02-23 | 东华大学 | Cellulose-reinforced glucan-based injectable antibacterial hydrogel dressing and preparation method thereof |
CN109157669A (en) * | 2018-09-18 | 2019-01-08 | 东华大学 | Cellulose enhances glucan base injectable anti-bacterial hydrogel dressing and preparation method thereof |
CN109734937A (en) * | 2019-01-08 | 2019-05-10 | 乐国平 | The preparation method of VA@PLGA-CS-HA/OHPMC-HA antibacterial injection aquagel |
CN109734937B (en) * | 2019-01-08 | 2021-05-14 | 乐国平 | Preparation method of VA @ PLGA-CS-HA/OHPPMC-HA antibacterial injectable hydrogel |
CN109718395A (en) * | 2019-02-28 | 2019-05-07 | 上海交通大学 | Based on the polysaccharide polymer injection aquagel and preparation method of dynamic imine linkage and application |
CN109939260A (en) * | 2019-03-01 | 2019-06-28 | 昆明理工大学 | A kind of preparation method of medical chitosan/Sodium Hyaluronate coupling hydrogel |
CN110199996A (en) * | 2019-05-10 | 2019-09-06 | 金华市呗力水产养殖技术有限公司 | A kind of preparation method of aquaculture fungicide |
CN110201219A (en) * | 2019-05-14 | 2019-09-06 | 浙江理工大学 | A kind of composite hydrogel and preparation method thereof of injectable and quick-gelatinizing |
CN111333878A (en) * | 2019-05-23 | 2020-06-26 | 吾奇生物医疗科技(镇江)有限公司 | Double-crosslinked chitosan hydrogel and preparation method and application thereof |
WO2021007899A1 (en) * | 2019-07-15 | 2021-01-21 | 浙江工业大学 | Injectable hydrogel material and preparation method therefor and use thereof |
CN110498936A (en) * | 2019-07-15 | 2019-11-26 | 北京化工大学 | A kind of preparation method of Sodium Hyaluronate/sodium alginate injection-type composite hydrogel |
CN110464871A (en) * | 2019-08-21 | 2019-11-19 | 南开大学 | A kind of injection aquagel and preparation method thereof |
CN110628090A (en) * | 2019-10-17 | 2019-12-31 | 陕西科技大学 | Cationic guar gum/chitosan composite hydrogel and preparation method thereof |
CN110628090B (en) * | 2019-10-17 | 2021-06-22 | 陕西科技大学 | Cationic guar gum/chitosan composite hydrogel and preparation method thereof |
CN111228212A (en) * | 2020-01-16 | 2020-06-05 | 中国人民解放军军事科学院军事医学研究院 | Drug-loaded injectable implantation in-situ hydrogel |
CN111303459A (en) * | 2020-01-20 | 2020-06-19 | 华南理工大学 | Preparation method of hyaluronic acid based double-crosslinked hydrogel |
CN111388755A (en) * | 2020-03-20 | 2020-07-10 | 东华大学 | Injectable hyaluronic acid/chitosan hydrogel and preparation method thereof |
CN111269332A (en) * | 2020-03-27 | 2020-06-12 | 广州古泉生物科技有限公司 | Preparation and application of chitosan-sodium alginate hydrogel |
CN111410753A (en) * | 2020-03-27 | 2020-07-14 | 西南大学 | Novel chitosan hydrogel and preparation method and application thereof |
CN111518289A (en) * | 2020-05-21 | 2020-08-11 | 山东大学 | Injectable self-healing hydrogel with adjustable mechanical properties and preparation method and application thereof |
CN111518289B (en) * | 2020-05-21 | 2021-11-19 | 山东大学 | Injectable self-healing hydrogel with adjustable mechanical properties and preparation method and application thereof |
CN111803707A (en) * | 2020-06-05 | 2020-10-23 | 上海大学 | Polysaccharide-based fiber composite in-situ pore-forming injectable hydrogel and preparation method thereof |
CN111471193B (en) * | 2020-06-15 | 2021-03-16 | 四川大学 | Dialdehyde polysaccharide nanoparticle crosslinked collagen hydrogel and preparation method thereof |
CN111471193A (en) * | 2020-06-15 | 2020-07-31 | 四川大学 | Dialdehyde polysaccharide nanoparticle crosslinked collagen hydrogel and preparation method thereof |
CN111704729B (en) * | 2020-07-02 | 2022-05-10 | 安徽省立医院(中国科学技术大学附属第一医院) | Hydrogel cell scaffold based on natural polymer and adjustable in strength and gelling time |
CN111704729A (en) * | 2020-07-02 | 2020-09-25 | 安徽省立医院(中国科学技术大学附属第一医院) | Hydrogel cell scaffold based on natural polymers and adjustable in strength and gelling time |
CN111909396A (en) * | 2020-07-21 | 2020-11-10 | 华南农业大学 | Natural polymer-based supramolecular self-healing hydrogel and preparation method and application thereof |
CN111662464B (en) * | 2020-07-23 | 2022-01-25 | 南京工业大学 | Preparation method of chitosan/sodium alginate double-network hydrogel |
CN111662464A (en) * | 2020-07-23 | 2020-09-15 | 南京工业大学 | Preparation method of chitosan/sodium alginate double-network hydrogel |
CN112043874B (en) * | 2020-09-21 | 2021-10-08 | 四川大学 | Three-phase hydrogel and preparation method thereof |
CN112043874A (en) * | 2020-09-21 | 2020-12-08 | 四川大学 | Three-phase hydrogel and preparation method and application thereof |
CN112646202B (en) * | 2020-11-27 | 2023-04-07 | 北京大学口腔医学院 | Functionalized double-network hydrogel and preparation method and application thereof |
CN112646202A (en) * | 2020-11-27 | 2021-04-13 | 北京大学口腔医学院 | Functionalized double-network hydrogel and preparation method and application thereof |
CN112386695A (en) * | 2020-11-30 | 2021-02-23 | 西安交通大学 | Chitosan-based nano prodrug carrying indocyanine green and platinum drugs and preparation method thereof |
CN112675355A (en) * | 2020-12-16 | 2021-04-20 | 北京大清生物技术股份有限公司 | Degradable medical hydrogel material and preparation method and application thereof |
CN112851983A (en) * | 2020-12-31 | 2021-05-28 | 东华大学 | Electrostatic spraying film of hydrogel and preparation method and application thereof |
CN114762736A (en) * | 2021-01-13 | 2022-07-19 | 中国科学院宁波材料技术与工程研究所慈溪生物医学工程研究所 | Ionic liquid modified chitosan hydrogel and preparation method and application thereof |
CN112843325A (en) * | 2021-01-20 | 2021-05-28 | 江苏德威兰医疗器械股份有限公司 | Medical hydrogel adhesive and preparation method and application thereof |
CN112920428B (en) * | 2021-01-27 | 2023-04-11 | 陈勇 | Composite hydrogel and preparation method thereof |
CN112920428A (en) * | 2021-01-27 | 2021-06-08 | 陈勇 | Composite hydrogel and preparation method thereof |
CN112940291B (en) * | 2021-02-05 | 2024-02-09 | 中国科学技术大学 | Transparent hydrogel based on chitosan and preparation method thereof |
CN112940291A (en) * | 2021-02-05 | 2021-06-11 | 中国科学技术大学 | Transparent hydrogel based on chitosan and preparation method thereof |
CN113024847A (en) * | 2021-03-19 | 2021-06-25 | 中国科学院宁波材料技术与工程研究所 | Application of natural polysaccharide hydrogel in hemostasis field |
CN113318276A (en) * | 2021-03-29 | 2021-08-31 | 中山大学附属第一医院 | Preparation method of multiple-crosslinking injectable hydrogel and preparation method and application thereof |
CN113152091A (en) * | 2021-04-21 | 2021-07-23 | 东华大学 | Polysaccharide-based hydrogel-based fabric for visually detecting escherichia coli and pH response and preparation method thereof |
CN113262198A (en) * | 2021-05-27 | 2021-08-17 | 江南大学 | Microgel and preparation method and application thereof |
CN113603905B (en) * | 2021-08-24 | 2024-01-12 | 武汉新思邦生物科技有限公司 | Adhesive hydrogel and preparation method thereof |
CN113603905A (en) * | 2021-08-24 | 2021-11-05 | 日照武汉理工大生物医药暨新材料研究院 | Adhesive hydrogel and preparation method thereof |
CN113956507A (en) * | 2021-09-27 | 2022-01-21 | 中国科学院宁波材料技术与工程研究所 | Injectable hydrogel and preparation method and application thereof |
CN114230812A (en) * | 2021-12-07 | 2022-03-25 | 广东省科学院健康医学研究所 | Functional hydrogel and preparation method and application thereof |
CN114366756B (en) * | 2021-12-16 | 2024-02-13 | 北京华量引擎网络科技有限公司 | Crosslinked chitosan hydrogel stomach filler and preparation method and application thereof |
CN114366756A (en) * | 2021-12-16 | 2022-04-19 | 佑道(天津)健康咨询有限公司 | Crosslinked chitosan hydrogel gastric filler and preparation method and application thereof |
CN114432494A (en) * | 2022-01-12 | 2022-05-06 | 宁波市第一医院 | Sanchinin-loaded hydrogel and preparation method thereof |
CN114712550A (en) * | 2022-04-20 | 2022-07-08 | 华中科技大学 | Hydrogel adhesive capable of being injected for rapid hemostasis and preparation method and application thereof |
CN114712550B (en) * | 2022-04-20 | 2023-02-14 | 华中科技大学 | Hydrogel adhesive capable of being injected for rapid hemostasis and preparation method and application thereof |
CN114796620B (en) * | 2022-04-24 | 2023-09-29 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Interpenetrating network hydrogel used as medical implant material and preparation method and application thereof |
CN114796620A (en) * | 2022-04-24 | 2022-07-29 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Interpenetrating network hydrogel used as medical implant material and preparation method and application thereof |
CN115010958A (en) * | 2022-05-13 | 2022-09-06 | 楼天女 | Hydrogel for promoting wound healing and preparation method and application thereof |
CN114848509A (en) * | 2022-05-24 | 2022-08-05 | 上海家化联合股份有限公司 | Polysaccharide-based gel containing polyhydroxy acids and uses thereof |
CN117285726A (en) * | 2022-06-16 | 2023-12-26 | 上海其胜生物制剂有限公司 | Injection type dynamic chitosan hydrogel and preparation method and application thereof |
CN117285726B (en) * | 2022-06-16 | 2024-07-16 | 上海其胜生物制剂有限公司 | Injection type dynamic chitosan hydrogel and preparation method and application thereof |
CN115463622A (en) * | 2022-08-03 | 2022-12-13 | 广东纤友朵美生物科技有限公司 | Gel based on oxidized pectin and preparation method thereof |
CN115746412A (en) * | 2022-10-25 | 2023-03-07 | 南方科技大学 | Water-soluble chitosan composite hydrogel and preparation method and application thereof |
CN115746412B (en) * | 2022-10-25 | 2024-01-16 | 南方科技大学 | Water-soluble chitosan composite hydrogel and preparation method and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104479150A (en) | Preparation method of multiple cross-linked polysaccharide injectable hydrogel | |
Teng et al. | Recent development of alginate-based materials and their versatile functions in biomedicine, flexible electronics, and environmental uses | |
Ding et al. | Novel self-healing hydrogel with injectable, pH-responsive, strain-sensitive, promoting wound-healing, and hemostatic properties based on collagen and chitosan | |
Pourjavadi et al. | Injectable chitosan/κ-carrageenan hydrogel designed with au nanoparticles: A conductive scaffold for tissue engineering demands | |
Ding et al. | Tough and cell-compatible chitosan physical hydrogels for mouse bone mesenchymal stem cells in vitro | |
Qiao et al. | Preparation of printable double-network hydrogels with rapid self-healing and high elasticity based on hyaluronic acid for controlled drug release | |
Cimen et al. | Injectable and self-healable pH-responsive gelatin–PEG/laponite hybrid hydrogels as long-acting implants for local cancer treatment | |
US11672756B2 (en) | Temperature sensitive hydrogel composition including nucleic acid and chitosan | |
ES2184521T5 (en) | RETICULATED HIALURONIC ACIDS AND THEIR MEDICAL USES. | |
CN106397846B (en) | A kind of cross-linking hyaluronic acid sodium and the preparation method and application thereof | |
Zhao et al. | Natural polymer-based hydrogels: From polymer to biomedical applications | |
Ranjha et al. | Chitosan/poly (vinyl alcohol) based hydrogels for biomedical applications: a review | |
CN106589424A (en) | Crosslinked hyaluronic acid gel for injection and preparation method thereof | |
CN103146002A (en) | Injectable polyglutamic acid chemical crosslinking hydrogel and preparation method thereof | |
CN102433006B (en) | Preparation method of thermo-sensitive sol-gel transformation material | |
CN103613686A (en) | Preparation method and application of sulfhydryl hyaluronic acid | |
BR112013012772B1 (en) | Preparation and / or formulation of polysaccharide crosslinked proteins | |
CN102827446B (en) | Temperature response type injectable hydrogel and preparation method and usage thereof | |
CN104086788A (en) | Modified sodium hyaluronate gel for injection | |
Liu et al. | Chitosan-based hemostatic sponges as new generation hemostatic materials for uncontrolled bleeding emergency: Modification, composition, and applications | |
CN102643498A (en) | Preparation method of water-absorbing gel containing animal and plant fibers and inorganic nanoparticles | |
Bi et al. | Homogeneous modification of chitin and chitosan based on an alkali/urea soluble system and their applications in biomedical engineering | |
CN106188584A (en) | A kind of derivatives of hyaluronic acids hydrogel and preparation method thereof | |
CN113425890A (en) | Bionic hydrogel tissue adhesive and preparation method thereof | |
Ren et al. | Injectable supramolecular hydrogels based on host–guest interactions with cell encapsulation capabilities |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150401 |