CN104474052B - A kind of compound spirit treating eczema - Google Patents

A kind of compound spirit treating eczema Download PDF

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CN104474052B
CN104474052B CN201410854362.7A CN201410854362A CN104474052B CN 104474052 B CN104474052 B CN 104474052B CN 201410854362 A CN201410854362 A CN 201410854362A CN 104474052 B CN104474052 B CN 104474052B
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radix
chinese medicine
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ethanol
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CN104474052A (en
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李秀英
李静
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of compound spirit treating eczema, this compound spirit is made up of Western medicine, Chinese medicine and solvent, and Western medicine effective ingredient and parts by weight thereof are: indomethacin 15～20 parts, domiphen bromide 0.5～1 part；The crude drug of Effective Component of Chinese Medicine and parts by weight thereof are: Radix Arnebiae (Radix Lithospermi) 150～200 parts, Flos Lonicerae 80～100 parts, Herba speranskiae tuberculatae 120 150 parts, Ramulus Mori 80～100 parts, Radix Aconiti Lateralis Preparata 180～200 parts, Rhizoma Atractylodis 70～90 parts, Radix Clematidis 120～150 parts；Solvent is ethanol, and alcohol quality concentration is 60～70%, and consumption is 1000 parts.Through getting the raw materials ready, the extraction of raw material of Chinese medicine pharmaceutically active ingredient, the dissolving of Western medicine effective ingredient be prepared from.Effective above composition and the synergism of solvent, effective heat clearing away, detoxify, sterilize, antiinflammatory, can the most antipruritic, pain relieving, effectively cure eczema, have no side effect, drug safety, make cheap.

Description

A kind of compound spirit treating eczema
Technical field
The present invention relates to treat the technical field of eczema, a kind of compound spirit treating eczema.
Background technology
Eczema is a kind of common epidermis caused by multiple internal and external factor and the inflammatory skin of high dermis Disease, is the skin atopic reaction for materials such as chemicals, albumen, antibacterial and funguses.Eczema, though It not serious disease, not threat to life, but among the people generally reflection this disease has a headache very much, itch not only but also bitterly, even burn Heat.This type of disease is not had the Drug therapy of very specially good effect, a lot of large hospitals all to compare needle-holding hand by prior art.Institute Medicine mostly fall within Western medicine antiinflammatory and supplementary calcium etc, curative effect is the most limited.Most patients is to hospital Treatment, all can not cure, also spend countless, drive into poverty by medical crises for more than 10 year, and patient household is the most painful.
Summary of the invention
It is an object of the invention to lack for existing treatment eczema disease the deficiency of active drug, propose one Western medicine adds the compound spirit of Chinese medicine, and Western medicine and Effective Component of Chinese Medicine are combined by the present invention, mark This is the most double controls, and achieves preferable synergy, it is possible to effectively heat clearing away, detoxify, sterilize, antiinflammatory, the short time In antipruritic, relieve the pain, cure eczema, have no side effect, drug safety, make cheap.
The technical solution used in the present invention is:
A kind of compound spirit treating eczema, this compound spirit is made up of Western medicine, Chinese medicine and solvent, and Western medicine has Imitate composition and parts by weight are: indomethacin 15～20 parts, domiphen bromide 0.5～1 part；Effective Component of Chinese Medicine Crude drug and parts by weight thereof are: Radix Arnebiae (Radix Lithospermi) 150～200 parts, Flos Lonicerae 80～100 parts, Herba speranskiae tuberculatae 120-150 Part, Ramulus Mori 80～100 parts, Radix Aconiti Lateralis Preparata 180～200 parts, Rhizoma Atractylodis 70～90 parts, Radix Clematidis 120～150 parts；Molten Agent is ethanol, and alcohol quality concentration is 60～70%, and consumption is 1000 parts.
Further, a kind of compound spirit treating eczema, Western medicine effective ingredient and parts by weight thereof are: Yin U.S. pungent 16～18 parts of diindyl, domiphen bromide 0.6～0.8 part；The crude drug of Effective Component of Chinese Medicine and parts by weight thereof are: Radix Arnebiae (Radix Lithospermi) 160～180 parts, Flos Lonicerae 80～90 parts, Herba speranskiae tuberculatae 130～140 parts, Ramulus Mori 85～95 parts, Radix Aconiti Lateralis Preparata 185～195 parts, Rhizoma Atractylodis 75～85 parts, Radix Clematidis 130～140 parts.
Further, a kind of compound spirit treating eczema, Western medicine effective ingredient and parts by weight thereof are: Yin U.S. pungent 17 parts of diindyl, domiphen bromide 0.7 part；The crude drug of Effective Component of Chinese Medicine and parts by weight thereof are: Radix Arnebiae (Radix Lithospermi) 170 Part, Flos Lonicerae 85 parts, Herba speranskiae tuberculatae 135 parts, Ramulus Mori 90 parts, Radix Aconiti Lateralis Preparata 190 parts, Rhizoma Atractylodis 80 parts, Wheeling Celestial 135 parts.
Further, a kind of compound spirit treating eczema, alcohol quality concentration is 60～65%.
The present invention also provides for the preparation method of a kind of compound spirit treating eczema, specifically comprises the following steps that
Each constituent content the most as described above is got the raw materials ready, and wherein ethanol same volume gets the raw materials ready 2 parts, every part 500 Part；
2. the extraction of raw material of Chinese medicine pharmaceutically active ingredient: by Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Herba speranskiae tuberculatae, Ramulus Mori, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis, Radix Clematidis add in constant temperature extraction pot, add 1 part of ethanol in constant temperature extraction pot, will under stirring condition Material is heated to 75～80 DEG C of reflux, extract, 1h, is cooled to room temperature, takes supernatant；Add in constant temperature extraction pot Enter another part of ethanol, under stirring condition, material be heated to 75～80 DEG C of reflux, extract, 1h, be cooled to room temperature, Take supernatant；Merge twice gained supernatant, by supernatant through 16 layers of filtered through gauze, filtrate at pressure be -0.05～-0.08Mpa, temperature be concentrated under the conditions of being 40～45 DEG C that volume is former filtrate volume 1/2nd, It is cooled to room temperature；
4. will indomethacin, domiphen bromide addition step 2. gained the concentrated liquid of tradition Chinese medicine stir to all dissolving, point Bottle packages spare.
Using method:
Being coated with by compound spirit puts on the skin in affected part, and three times a day, the morning, noon and afternoon are the most once.
Effect of each effective ingredient is:
Indomethacin: be applicable to antipyretic, alleviate inflammatory pain effect obvious.
Domiphen bromide: cationic surfactant spectrum antibacterial.
Radix Arnebiae (Radix Lithospermi): clearing away heat and cooling blood, invigorates blood circulation, rash of detoxifying.
Flos Lonicerae: heat-clearing and toxic substances removing, wind-heat dissipating, medicinal efficacy is: the most antibacterial and antiviral, 2. strengthens and exempts from The function of epidemic disease, 3. antiinflammatory, antipyretic.
Herba speranskiae tuberculatae: expelling wind and removing dampness, the pungent temperature of these product, pungent energy be manageed it scattered, and temperature overcomes the coldness wet；Relaxing muscles and tendons and activating QI and blood in the collateral, these product are pungent Dissipate temperature logical, enter Liver Channel, and liver governing tendons, therefore these product have effect of relaxing muscles and tendons and activating QI and blood in the collateral；Promoting blood circulation and stopping pain, these product are pungent Dissipate temperature logical, enter Liver Channel blood system, thus can promoting blood circulation and stopping pain, solution poisons rash.
Ramulus Mori: wind-damp dispelling, the meridian dredging, row aqueous vapor；Main air pain of dampness syndrome, apoplexy and hemiplegia, edema tinea pedis, Human body pruritus due to wind pathogen；For takeing on arm, joint aches numbness.
Radix Aconiti Lateralis Preparata: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispelling cold and removing dampness；Controlling excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted Inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, tinea pedis edema children's's intermittent infantile convulsion, anemofrigid-damp arthralgia, contracture, sexual impotence, Cold womb is cloudy, and cellulitis skin ulcer is leaked and all are heavy cold.
Rhizoma Atractylodis: spleen invigorating, dampness, resolving depression, ward off dirty.Control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, food It is intended to depressed, vomiting, have loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, Nyctalopia.
Radix Clematidis: expelling wind and removing dampness；Removing obstruction in the collateral to relieve pain.Cure mainly rheumatic arthralgia；Numb limbs and tense tendons；Muscle arteries and veins contracture； Joint stuffiness；Tinea pedis swells and ache；Malaria；Bone is choked with sobs larynx；And control phlegm retention accumulation.
Beneficial effects of the present invention:
The compound spirit of the treatment eczema of the present invention has that curative effect is fast, treating both the principal and secondary aspects of a disease, have no side effect, cost Cheap advantage, uses Chinese and Western medicine mixture, it is possible to effectively heat clearing away, detoxifies, sterilize, in antiinflammatory, and short time Antipruritic, pain relieving, cure eczema, this compound spirit can rapid recovery patient suffering, effect a radical cure eczema, simultaneously Alleviate the financial burden of patient.Specifically:
1. Herba speranskiae tuberculatae joins Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata pungent sweet property heat, dispelling cold and eliminating dampness, partially walk kidney channel, warming the kidney to activate YANG, walk and Do not keep, inside reach and pass through inside, lift active two medicines and share, similar from, bring out the best in each other, Liver and kidney is ruled together, QI and blood All adjust, except severe and lingering illness, control insensitive impediment and especially imitate.Joining Rhizoma Atractylodis, a dampness is the longest, and a pain relieving is gained merit, and two medicine mutual reinforcements between are With, damp-clearing pain-relieving, effect increases.Join Ramulus Mori, the sensible extremity of Ramulus Mori, network of passing through, profit joint, helps the efficacy of a drug. Joining Radix Clematidis, Radix Clematidis leads to 12 warps, and its property is walked to alter, dispelling wind and removing obstruction in the collateral, is apt to control numb limbs and tense tendons, and two medicines share, The former temperature three-way meridian, the latter's wind-expelling pain-stopping, with controlling wind, cold, wet numbness, all play outstanding service.Radix Arnebiae (Radix Lithospermi) can be invigorated blood circulation Blood stasis dispelling, promotes local microcirculation, promotes that medicine indomethacin, domiphen bromide can preferably absorb and onset.
2. mass concentration be 75% ethanol there is preferable sterilizing effect, the preparation method of the present invention makes With the ethanol that mass concentration is 60～70%, through the extraction step of Effective Component of Chinese Medicine, alcohol quality concentration exists About 75%, the effect contributing to Chinese medicine and western medicine effective ingredient plays.
3. the compound spirit prepared by this method, has reached preferable synergistic action effect, it is possible to the most clear Heat, detoxify, sterilize, antiinflammatory, antipruritic in the short time, pain relieving, healing eczema, have no side effect, medication Safety, makes cheap.
4. the raw materials used low cost of the present invention, preparation method is simple, is greatly reduced cost of manufacture, and makes Fast by curative effect, treatment cycle is short, effectively reduces the financial burden of patient.
Detailed description of the invention
According to following embodiment, the present invention be may be better understood.But, those skilled in the art is easy Understanding, concrete material proportion, process conditions and result thereof described by embodiment are merely to illustrate the present invention And should be also without limitation on the present invention described in detail in claims.
Embodiment 1
A kind of compound spirit treating eczema, Western medicine effective ingredient and weight thereof is: indomethacin 17g, spends rice Fragrant 0.7g；The crude drug of Effective Component of Chinese Medicine and weight thereof is: Radix Arnebiae (Radix Lithospermi) 170g, Flos Lonicerae 85g, Herba speranskiae tuberculatae 135g, Ramulus Mori 90g, Radix Aconiti Lateralis Preparata 190g, Rhizoma Atractylodis 80g, Radix Clematidis 135g, alcohol quality concentration is 65%, Consumption is 1000g.
A kind of compound spirit preparation method treating eczema:
Each constituent content the most as described above is got the raw materials ready, and wherein ethanol gets the raw materials ready 2 parts, every part of 500g；
2. the extraction of raw material of Chinese medicine pharmaceutically active ingredient: by Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Herba speranskiae tuberculatae, Ramulus Mori, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis, Radix Clematidis add in constant temperature extraction pot, add 1 part of ethanol in constant temperature extraction pot, will under stirring condition Material is heated to 75～80 DEG C of reflux, extract, 1h, is cooled to room temperature, takes supernatant；Add in constant temperature extraction pot Enter another part of ethanol, under stirring condition, material be heated to 75～80 DEG C of reflux, extract, 1h, be cooled to room temperature, Take supernatant；Merge twice gained supernatant, by supernatant through 16 layers of filtered through gauze, filtrate at pressure be -0.05～-0.08Mpa, temperature be concentrated under the conditions of being 40～45 DEG C that volume is former filtrate volume 1/2nd, It is cooled to room temperature；
4. will indomethacin, domiphen bromide addition step 2. gained the concentrated liquid of tradition Chinese medicine stir to all dissolving, point Bottle packages spare.
A kind of compound spirit using method treating eczema:
Being coated with by compound spirit puts on the skin in affected part, and three times a day, the morning, noon and afternoon are the most once.
Embodiment 2
A kind of compound spirit treating eczema, Western medicine effective ingredient and weight thereof is: indomethacin 15g, spends rice Fragrant 0.5g；The crude drug of Effective Component of Chinese Medicine and weight thereof is: Radix Arnebiae (Radix Lithospermi) 160g, Flos Lonicerae 90g, Herba speranskiae tuberculatae 130g, Ramulus Mori 95g, Radix Aconiti Lateralis Preparata 195g, Rhizoma Atractylodis 75g, Radix Clematidis 130g；Alcohol quality concentration is 60%, Consumption is 1000g.
A kind of compound spirit preparation method treating eczema:
Each constituent content the most as described above is got the raw materials ready, and wherein ethanol gets the raw materials ready 2 parts, every part of 500g；
2. the extraction of raw material of Chinese medicine pharmaceutically active ingredient: by Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Herba speranskiae tuberculatae, Ramulus Mori, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis, Radix Clematidis add in constant temperature extraction pot, add 1 part of ethanol in constant temperature extraction pot, will under stirring condition Material is heated to 75～80 DEG C of reflux, extract, 1h, is cooled to room temperature, takes supernatant；Add in constant temperature extraction pot Enter another part of ethanol, under stirring condition, material be heated to 75～80 DEG C of reflux, extract, 1h, be cooled to room temperature, Take supernatant；Merge twice gained supernatant, by supernatant through 16 layers of filtered through gauze, filtrate at pressure be -0.05～-0.08Mpa, temperature be concentrated under the conditions of being 40～45 DEG C that volume is former filtrate volume 1/2nd, It is cooled to room temperature；
4. will indomethacin, domiphen bromide addition step 2. gained the concentrated liquid of tradition Chinese medicine stir to all dissolving, point Bottle packages spare.
Using method:
Being coated with by compound spirit puts on the skin in affected part, and every day 2～3 times, the morning, noon and afternoon are the most once.
Embodiment 3
A kind of compound spirit treating eczema, Western medicine effective ingredient and weight thereof is: indomethacin 20g, spends rice Fragrant 0.7g；The crude drug of Effective Component of Chinese Medicine and weight thereof is: Radix Arnebiae (Radix Lithospermi) 150g, Flos Lonicerae 80g, Herba speranskiae tuberculatae 140g, Ramulus Mori 85g, Radix Aconiti Lateralis Preparata 185g, Rhizoma Atractylodis 85g, Radix Clematidis 140g；Alcohol quality concentration is 70%, Consumption is 1000g.
A kind of compound spirit preparation method treating eczema:
Each constituent content the most as described above is got the raw materials ready, and wherein ethanol gets the raw materials ready 2 parts, every part of 500g；
2. the extraction of raw material of Chinese medicine pharmaceutically active ingredient: by Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Herba speranskiae tuberculatae, Ramulus Mori, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis, Radix Clematidis add in constant temperature extraction pot, add 1 part of ethanol in constant temperature extraction pot, will under stirring condition Material is heated to 75～80 DEG C of reflux, extract, 1h, is cooled to room temperature, takes supernatant；Add in constant temperature extraction pot Enter another part of ethanol, under stirring condition, material be heated to 75～80 DEG C of reflux, extract, 1h, be cooled to room temperature, Take supernatant；Merge twice gained supernatant, by supernatant through 16 layers of filtered through gauze, filtrate at pressure be -0.05～-0.08Mpa, temperature be concentrated under the conditions of being 40～45 DEG C that volume is former filtrate volume 1/2nd, It is cooled to room temperature；
4. will indomethacin, domiphen bromide addition step 2. gained the concentrated liquid of tradition Chinese medicine stir to all dissolving, point Bottle packages spare.
Using method:
Being coated with by compound spirit puts on the skin in affected part, and three times a day, the morning, noon and afternoon are the most once.
Embodiment 4
A kind of compound spirit treating eczema, Western medicine effective ingredient and weight thereof is: indomethacin 16g, spends rice Fragrant 0.5g；The crude drug of Effective Component of Chinese Medicine and weight thereof is: Radix Arnebiae (Radix Lithospermi) 200g, Flos Lonicerae 100g, Herba speranskiae tuberculatae 120g, Ramulus Mori 80g, Radix Aconiti Lateralis Preparata 180g, Rhizoma Atractylodis 90g, Radix Clematidis 150g.Alcohol quality concentration is 70%, Consumption is 1000g.
A kind of compound spirit preparation method treating eczema:
Each constituent content the most as described above is got the raw materials ready, and wherein ethanol gets the raw materials ready 2 parts, every part of 500g；
2. the extraction of raw material of Chinese medicine pharmaceutically active ingredient: by Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Herba speranskiae tuberculatae, Ramulus Mori, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis, Radix Clematidis add in constant temperature extraction pot, add 1 part of ethanol in constant temperature extraction pot, will under stirring condition Material is heated to 75～80 DEG C of reflux, extract, 1h, is cooled to room temperature, takes supernatant；Add in constant temperature extraction pot Enter another part of ethanol, under stirring condition, material be heated to 75～80 DEG C of reflux, extract, 1h, be cooled to room temperature, Take supernatant；Merge twice gained supernatant, by supernatant through 16 layers of filtered through gauze, filtrate at pressure be -0.05～-0.08Mpa, temperature be concentrated under the conditions of being 40～45 DEG C that volume is former filtrate volume 1/2nd, It is cooled to room temperature；
4. will indomethacin, domiphen bromide addition step 2. gained the concentrated liquid of tradition Chinese medicine stir to all dissolving, point Bottle packages spare.
Using method:
Being coated with by compound spirit puts on the skin in affected part, and three times a day, the morning, noon and afternoon are the most once.
Embodiment 5
A kind of compound spirit treating eczema, Western medicine effective ingredient and weight thereof is: indomethacin 18g, spends rice Fragrant 0.9g；The crude drug of Effective Component of Chinese Medicine and weight thereof is: Radix Arnebiae (Radix Lithospermi) 180g, Flos Lonicerae 90g, Herba speranskiae tuberculatae 150g, Ramulus Mori 100g, Radix Aconiti Lateralis Preparata 200g, Rhizoma Atractylodis 70g, Radix Clematidis 120g, alcohol quality concentration is 60%, Consumption is 1000g.
A kind of compound spirit preparation method treating eczema:
Each constituent content the most as described above is got the raw materials ready, and wherein ethanol gets the raw materials ready 2 parts, every part of 500g；
2. the extraction of raw material of Chinese medicine pharmaceutically active ingredient: by Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Herba speranskiae tuberculatae, Ramulus Mori, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis, Radix Clematidis add in constant temperature extraction pot, add 1 part of ethanol in constant temperature extraction pot, will under stirring condition Material is heated to 75～80 DEG C of reflux, extract, 1h, is cooled to room temperature, takes supernatant；Add in constant temperature extraction pot Enter another part of ethanol, under stirring condition, material be heated to 75～80 DEG C of reflux, extract, 1h, be cooled to room temperature, Take supernatant；Merge twice gained supernatant, by supernatant through 16 layers of filtered through gauze, filtrate at pressure be -0.05～-0.08Mpa, temperature be concentrated under the conditions of being 40～45 DEG C that volume is former filtrate volume 1/2nd, It is cooled to room temperature；
4. will indomethacin, domiphen bromide addition step 2. gained the concentrated liquid of tradition Chinese medicine stir to all dissolving, point Bottle packages spare.
Using method:
Being coated with by compound spirit puts on the skin in affected part, and three times a day, the morning, noon and afternoon are the most once.
The pharmacodynamic analysis of the present invention:
1) clinical data
The present invention is used for treating eczema patients 138 example and carrying out clinical observation treatment, wherein age reckling 21 Year, the maximum 60 years old, 45 years old mean age, the course of disease 6 months to 10 years.
2) efficacy assessment standard
Cure: common disease such as skin occurs that lamellar, strip or indefinite shape are red and swollen, has when oozing out and can have crust Skin covers, and erosion or ulcer can be had to occur when skin has damage, and local has sufferings sense etc. all to disappear.
Take a turn for the better: conscious disease such as skin occurs that lamellar, strip or indefinite shape are red and swollen, has when oozing out and can have crust Skin covers, and erosion or ulcer can be had to occur when skin has damage, and there are the partial disappearance such as sufferings sense local.
Invalid: symptom is not improved.
3) Therapeutic Method
Being coated with by compound spirit puts on the skin in affected part, and three times a day, the morning, noon and afternoon are the most once.
4) therapeutic effect: a kind of compound spirit treating eczema of the present invention is fully recovered through treatment, 112 examples, 22 examples take a turn for the better, and 4 examples are invalid；Through statistical analysis, cure rate reaches 81.16%, and total effective rate reaches 97.10%, Have no any untoward reaction over the course for the treatment of, show drug safety.
Model case:
Case 1: patient Wang, man, 38 years old, patient suffered from eczema 3 years, and affected skin has lamellar red and swollen, Disease sites has pain gargalesthesia, and ulcer occurs in portion, uses a kind of compound recipe tincture treating eczema of the present invention After agent 2 weeks, symptom substantially alleviates, and after being continuing with 4 weeks, symptom is wholly absent, and follows up a case by regular visits to 1 year not recur.
Case 2: grandson patient, female, 40 years old.Patient suffers from eczema 2 years, and waist affected skin has strip red and swollen, Disease sites has a pain gargalesthesia, use the present invention a kind of treat the compound spirit of eczema after 5 weeks symptom substantially subtract Gently, after being continuing with 3 weeks, symptom is wholly absent, and follows up a case by regular visits to 2 years not recur.
Case 3: patient's journey, man, 50 years old.Patient suffers from eczema 5 years, and affected skin has unsetting redness, And with pain gargalesthesia, portion has crust to cover, and uses a kind of compound spirit 4 treating eczema of the present invention After week, symptom substantially alleviates, and after being continuing with 4 weeks, symptom is wholly absent, and follows up a case by regular visits to 2 years not recur.
Embodiment of above only for technology design and the feature of the present invention are described, its object is to allow and is familiar with this The people of technology understands present invention and is carried out, and can not limit the scope of the invention with this, all The equivalence change done according to spirit of the invention or modification, all should contain within the scope of the present invention.

Claims (5)

1. the compound spirit treating eczema, it is characterised in that this compound spirit is by Western medicine, Chinese medicine and molten Agent forms, and Western medicine effective ingredient and parts by weight thereof are: indomethacin 15～20 parts, domiphen bromide 0.5～1 part； The crude drug of Effective Component of Chinese Medicine and parts by weight thereof are: Radix Arnebiae (Radix Lithospermi) 150～200 parts, Flos Lonicerae 80～100 parts, Herba speranskiae tuberculatae 120-150 part, Ramulus Mori 80～100 parts, Radix Aconiti Lateralis Preparata 180～200 parts, Rhizoma Atractylodis 70～90 parts, Radix Clematidis 120～150 parts；Solvent is ethanol, and alcohol quality concentration is 60～70%, and consumption is 1000 parts.
A kind of compound spirit treating eczema the most according to claim 1, it is characterised in that Western medicine has Imitate composition and parts by weight are: indomethacin 16～18 parts, domiphen bromide 0.6～0.8 part；Effective Component of Chinese Medicine Crude drug and parts by weight be: Radix Arnebiae (Radix Lithospermi) 160～180 parts, Flos Lonicerae 80～90 parts, Herba speranskiae tuberculatae 130～140 Part, Ramulus Mori 85～95 parts, Radix Aconiti Lateralis Preparata 185～195 parts, Rhizoma Atractylodis 75～85 parts, Radix Clematidis 130～140 parts.
A kind of compound spirit treating eczema the most according to claim 1, it is characterised in that Western medicine has Imitate composition and parts by weight are: indomethacin 17 parts, domiphen bromide 0.7 part；The raw material of Effective Component of Chinese Medicine Medicine and parts by weight thereof are: Radix Arnebiae (Radix Lithospermi) 170 parts, Flos Lonicerae 85 parts, Herba speranskiae tuberculatae 135 parts, Ramulus Mori 90 parts, Radix Aconiti Lateralis Preparata 190 parts, Rhizoma Atractylodis 80 parts, Radix Clematidis 135 parts.
A kind of compound spirit treating eczema the most according to claim 1, it is characterised in that ethanol matter Amount concentration is 60～65%.
5. the preparation method of the compound spirit treating eczema:
1. getting the raw materials ready according to each constituent content described in any one of Claims 1 to 4, wherein ethanol same volume gets the raw materials ready 2 Part, 500 parts every part；
2. the extraction of raw material of Chinese medicine pharmaceutically active ingredient: by Radix Arnebiae (Radix Lithospermi), Flos Lonicerae, Herba speranskiae tuberculatae, Ramulus Mori, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis, Radix Clematidis add in constant temperature extraction pot, add 1 part of ethanol in constant temperature extraction pot, will under stirring condition Material is heated to 75～80 DEG C of reflux, extract, 1h, is cooled to room temperature, takes supernatant；Add in constant temperature extraction pot Enter another part of ethanol, under stirring condition, material be heated to 75～80 DEG C of reflux, extract, 1h, be cooled to room temperature, Take supernatant；Merge twice gained supernatant, by supernatant through 16 layers of filtered through gauze, filtrate at pressure be -0.05～-0.08Mpa, temperature be concentrated under the conditions of being 40～45 DEG C that cumulative volume is former filtrate volume 1/2nd, It is cooled to room temperature；
3. will indomethacin, domiphen bromide addition step 2. gained the concentrated liquid of tradition Chinese medicine stir to all dissolving, point Bottle packages spare.
CN201410854362.7A 2014-12-31 2014-12-31 A kind of compound spirit treating eczema Expired - Fee Related CN104474052B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327827A (en) * 2001-06-21 2001-12-26 贵州宏奇药业有限公司 Exterior-applied medicine for treating dermatopathy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1327827A (en) * 2001-06-21 2001-12-26 贵州宏奇药业有限公司 Exterior-applied medicine for treating dermatopathy

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