CN104472513A - Penoxsulam water-dispersible tablet and preparation method thereof - Google Patents
Penoxsulam water-dispersible tablet and preparation method thereof Download PDFInfo
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- CN104472513A CN104472513A CN201410716475.0A CN201410716475A CN104472513A CN 104472513 A CN104472513 A CN 104472513A CN 201410716475 A CN201410716475 A CN 201410716475A CN 104472513 A CN104472513 A CN 104472513A
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Abstract
The invention discloses a penoxsulam water-dispersible tablet which comprises the following raw materials in percentage by weight: 1-20% of penoxsulam, 0.1-30% of wetting and dispersing agent, 1-40% of co-disintegrant, 0.1-20% of adhesive, 0.1-30% of flow control agent and the balance of filler carrier. The invention also discloses a preparation method of a penoxsulam water-dispersible tablet, which comprises the following steps: preparing solid raw materials into dry powder with certain fineness, adding water to prepare a soft material, granulating, drying, and finally tabletting to obtain the penoxsulam water-dispersible tablet. The tablet can overcome the defect of high use and processing cost in the traditional penoxsulam preparations (oil suspending agent and emulsifier). When in use, the tablet can be directly added into a water-containing sprayer, and the penoxsulam is uniformly dispersed in water due to high disintegration rate; and the penoxsulam solution can be sprayed to weed in the rice paddy field or directly sprayed to the rice paddy field, and thus, is very convenient to use.
Description
Technical field
The present invention relates to formulations of pesticide manufacture field, be specifically related to a kind of penoxsuam aqueous dispersion tablets and preparation method thereof.
Background technology
Penoxsuam molecular formula: C
16h
14f
5n
5o
5s, chemical name: 3-(2,2-difluoroethoxy)-N-(5,8-dimethoxy-[1,2,4] triazol [1,5-C] pyrimidine-2-base)-α, α, α-fluoroform phenyl-2-sulfonamide.For rice field broad-spectrum herbicide, barnyard grass (comprising the barnyard grass to Stam F-34, dichloro quinolinic acid and anti-acetyl-CoA carboxylase tool resistance), moleplant seed and annual sedge weed effectively can be prevented and kill off, and effective to numerous broad leaved weed.Lasting period reaches 30-60 days, a drug energy basic controlling full season Weed infestation.Meanwhile, it also can prevent and kill off anti-bensulfuron-methyl weeds in rice field, and has residual activity to many broad-leaveds and sedge weed and barnyard grass etc., is the kind that herbicide spectrum in current herbicide for rice field is the widest.Experimental results demonstrate, penoxsuam is fool proof to paddy rice.
Penoxsuam is translocated herbicide, through cauline leaf, young shoot and Root Absorption, conducts to meristematic tissue by xylem and phloem, suppresses plant strain growth, makes growing point chlorosis, and after process, 7-14d terminal bud reddens, downright bad, and 2-4 week plant is dead; This agent is strong inhibitor of acetolactate synthetase, and medicament presents comparatively slow, needs certain hour weeds just dead gradually.
Penoxsuam is applicable to the direct-sowing dry field of paddy rice, direct-sowing rice, rice seedling bed and rice transplanting, rice transplanting cultivation field.Consumption is 15-30g a.i./hm2.Direct-sowing dry Tian Yuya is front or after pouring water, water direct seeding seedling is applied in early days after seedling; Rice transplanting cultivation then 5-7d dispenser after rice transplanting.Insecticide-applying way can adopt spraying or mix soil process.
The main formulation of existing penoxsuam is oil-suspending agent, suspending agent.Through retrieval, penoxsuam is made aqueous dispersion tablets and application thereof and there is no people's report.
Summary of the invention
The object of the present invention is to provide a kind of high-load, environment-friendly type, availability is high, and in water, can be dispersed into the penoxsuam aqueous dispersion tablets of unit for uniform suspension by fater disintegration, to overcome exist in prior art environmental pollution, be detrimental to health and the shortcoming such as use cost is high.
The technical solution used in the present invention is as follows:
An aqueous dispersion tablets for penoxsuam, the percentage by weight of each component is: penoxsuam 1-20%, and wetting dispersing agent 0.1-30% helps disintegrant 1-40%, binding agent 0.1-20%, flowing regulator 0.1-30%, and surplus is filling carrier.
Described wetting dispersing agent is selected from two or more of following composition: sodium butylnaphthalenesulfonate, lauryl sodium sulfate, neopelex, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkylphenol polyoxyethylene formaldehyde condensation products sulfate phosphates, styrene phenol formaldehyde resin polyoxyethylene ether phosphate salt, styryl phenol polyethenoxy polyethenoxy ether, alkyl naphthalene formaldehyde condensate sulfonates, dialkyl succinylsuccinate sulfonated ester, naphthalene formaldehyde condensate sulfonates, lignin, lignosulfonates, macromolecule EO-PO block copolymer, to methoxyl group fatty acyl anilinesulfonic acid, one or more mixing in polycarboxylic acid salt.
The described disintegrant that helps is selected from: one or more mixing in modified starch, mineral salt, white carbon, ammonium sulfate, anhydrous sodium sulfate, sodium chloride, calcium chloride, bentonite, polyethyl acrylate, sodium alginate, sodium carboxymethyl starch, Ac-Di-Sol, crospolyvinylpyrrolidone.
Described binding agent is selected from: one or more mixing in carboxymethyl cellulose, polyvinylpyrrolidone, polyethylene glycol, sucrose, polyvinyl alcohol, Sodium Polyacrylate, starch, dextrin, lactose.
Described flowing regulator is selected from: one or more mixing in talcum powder, dolomol, stearate, white carbon.
Described filling carrier is selected from: one or more mixing in kaolin, diatomite, attapulgite, modified soluble starch, white carbon, glucose, precipitated calcium carbonate, anhydrous sodium sulfate, urea, mineral salt.
The preparation method of the aqueous dispersion tablets of described penoxsuam comprises the steps:
(1) by former for penoxsuam medicine, wetting dispersing agent, help disintegrant, binding agent, filling carrier to mix, after coarse crushing, then through airslide disintegrating mill pulverize, make fineness of materials reach the material of 99% by 325 mesh standard sieves, obtain certain fineness dry powder.
(2) add suitable quantity of water and make softwood, carry out granulation with squash type comminutor, under 45-55 DEG C of condition, be dried to particle water content be less than 3%, screening, particle size range about 2000 μm.
(3) add flowing regulator, mix, obtain aqueous dispersion tablets by tabletting machine.
The using method of the aqueous dispersion tablets of described penoxsuam is: the insecticide-applying way adopting spraying after being dissolved according to appropriate ratio by aqueous dispersion tablets, also directly can throw and execute in paddy field, not need special medical instruments.。
Advantage of the present invention:
(1) penoxsuam is made aqueous dispersion tablets, the use of conventional formulation oil-suspending agent emulsifier and the high shortcoming of processing cost can be avoided.
(2) aqueous dispersion tablets directly can be dropped in the sprayer be filled with water when using, because the very fast penoxsuam of disintegration is distributed in water equably, spray application, in various crop, also directly can be thrown and execute in paddy field, very easy to use.
(3) volume of the present invention is little, transports and store very convenient, and environmental protection, with low cost, be convenient to suitability for industrialized production.
Embodiment
In the embodiment of the following stated, unless otherwise indicated, all percentage is all weight percentage.
Embodiment 1:
Take the former powder 5% of penoxsuam, lauryl sodium sulfate 2%, lignosulfonates 10%, ammonium sulfate 20%, carboxymethyl cellulose 3%, kaolin complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 45-55 DEG C of condition, finally adds talcum powder 3%, after mixing; namely obtain aqueous dispersion tablets by tabletting machine, the large I of tablet is determined as required.This penoxsuam aqueous dispersion tablets can fater disintegration in water, and forms uniform suspension.
Embodiment 2:
Take the former powder 10% of penoxsuam, neopelex 4%, naphthalene formaldehyde condensate sulfonates 8%, modified starch 30%, polyvinylpyrrolidone 4%, urea complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 45-55 DEG C of condition, finally adds dolomol 1%, after mixing; namely obtain aqueous dispersion tablets by tabletting machine, the large I of tablet is determined as required.This penoxsuam aqueous dispersion tablets can fater disintegration in water, and forms uniform suspension.
Embodiment 3:
Take the former powder 15% of penoxsuam, sodium butylnaphthalenesulfonate 3%, polycarboxylate 12%, sodium chloride 25%, dextrin 5%, modified soluble starch complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 45-55 DEG C of condition, finally adds dolomol 2%, after mixing; namely obtain aqueous dispersion tablets by tabletting machine, the large I of tablet is determined as required.This penoxsuam aqueous dispersion tablets can fater disintegration in water, and forms uniform suspension.
Embodiment 4:
Take the former powder 20% of penoxsuam, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 4%, alkyl naphthalene formaldehyde condensate sulfonates 10%, sodium alginate 20%, polyethylene glycol 4%, diatomite complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 45-55 DEG C of condition, finally adds white carbon 2%, after mixing; namely obtain aqueous dispersion tablets by tabletting machine, the large I of tablet is determined as required.This penoxsuam aqueous dispersion tablets can fater disintegration in water, and forms uniform suspension.
Embodiment 5:
Take the former powder 25% of penoxsuam, lauryl sodium sulfate 3%, naphthalene formaldehyde condensate sulfonates 10%, Ac-Di-Sol 30%, polyvinylpyrrolidone 2%, precipitated calcium carbonate complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 45-55 DEG C of condition, finally adds dolomol 1%, after mixing; namely obtain aqueous dispersion tablets by tabletting machine, the large I of tablet is determined as required.This penoxsuam aqueous dispersion tablets can fater disintegration in water, and forms uniform suspension.
Claims (8)
1. an aqueous dispersion tablets for penoxsuam, is characterized in that: the percentage by weight of each component is: penoxsuam 1-20%, and wetting dispersing agent 0.1-30% helps disintegrant 1-40%, binding agent 0.1-20%, flowing regulator 0.1-30%, and surplus is filling carrier.
2. the aqueous dispersion tablets of a kind of penoxsuam according to claim 1, it is characterized in that: described wetting dispersing agent is selected from two or more of following composition: sodium butylnaphthalenesulfonate, lauryl sodium sulfate, neopelex, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkylphenol polyoxyethylene formaldehyde condensation products sulfate phosphates, styrene phenol formaldehyde resin polyoxyethylene ether phosphate salt, styryl phenol polyethenoxy polyethenoxy ether, alkyl naphthalene formaldehyde condensate sulfonates, dialkyl succinylsuccinate sulfonated ester, naphthalene formaldehyde condensate sulfonates, lignin, lignosulfonates, macromolecule EO-PO block copolymer, to methoxyl group fatty acyl anilinesulfonic acid, one or more mixing in polycarboxylic acid salt.
3. the aqueous dispersion tablets of a kind of penoxsuam according to claim 1, is characterized in that: the described disintegrant that helps is selected from: one or more mixing in modified starch, mineral salt, white carbon, ammonium sulfate, anhydrous sodium sulfate, sodium chloride, calcium chloride, bentonite, polyethyl acrylate, sodium alginate, sodium carboxymethyl starch, Ac-Di-Sol, crospolyvinylpyrrolidone.
4. the aqueous dispersion tablets of a kind of penoxsuam according to claim 1, is characterized in that: described binding agent is selected from: one or more mixing in carboxymethyl cellulose, polyvinylpyrrolidone, polyethylene glycol, sucrose, polyvinyl alcohol, Sodium Polyacrylate, starch, dextrin, lactose.
5. the aqueous dispersion tablets of a kind of penoxsuam according to claim 1, is characterized in that: described flowing regulator is selected from: the one in talcum powder, dolomol, stearate, white carbon.
6. the aqueous dispersion tablets of a kind of penoxsuam according to claim 1, is characterized in that: described filling carrier is selected from: one or more mixing in kaolin, diatomite, attapulgite, modified soluble starch, white carbon, glucose, precipitated calcium carbonate, anhydrous sodium sulfate, urea, mineral salt.
7. the preparation method of the aqueous dispersion tablets of a kind of penoxsuam according to claim 1, is characterized in that, comprise the steps:
(1) by former for penoxsuam medicine, wetting dispersing agent, help disintegrant, binding agent, filling carrier to mix, after coarse crushing, then through airslide disintegrating mill pulverize, make fineness of materials reach the material of 99% by 325 mesh standard sieves, obtain certain fineness dry powder;
(2) add suitable quantity of water and make softwood, carry out granulation with squash type comminutor, under 45-55 DEG C of condition, be dried to particle water content be less than 3%, screening, particle size range about 2000 μm;
(3) add flowing regulator, mix, obtain aqueous dispersion tablets by tabletting machine.
8. the using method of the aqueous dispersion tablets of a kind of penoxsuam according to claim 1, it is characterized in that: the insecticide-applying way adopting spraying after being dissolved according to appropriate ratio by aqueous dispersion tablets, also can directly throw executes in paddy field, does not need special medical instruments.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410716475.0A CN104472513A (en) | 2014-12-02 | 2014-12-02 | Penoxsulam water-dispersible tablet and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410716475.0A CN104472513A (en) | 2014-12-02 | 2014-12-02 | Penoxsulam water-dispersible tablet and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887086A (en) * | 2005-06-28 | 2007-01-03 | 张宗俭 | Water dispersed tablet of sulfonylurea and/or sulfamide herbicide and its prepn |
| WO2010126812A1 (en) * | 2009-05-01 | 2010-11-04 | Dow Agrosciences Llc | Safening penoxsulam herbicide injury in water-seeded, direct-seeded and transplanted paddy rice |
| CN102187860A (en) * | 2010-11-22 | 2011-09-21 | 南通联农农药制剂研究开发有限公司 | Water dispersible tablet and its preparation method |
| CN103348975A (en) * | 2012-08-22 | 2013-10-16 | 安阳市全丰农药化工有限责任公司 | Choline chloride water dispersible granule/tablet and preparation method thereof |
-
2014
- 2014-12-02 CN CN201410716475.0A patent/CN104472513A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887086A (en) * | 2005-06-28 | 2007-01-03 | 张宗俭 | Water dispersed tablet of sulfonylurea and/or sulfamide herbicide and its prepn |
| WO2010126812A1 (en) * | 2009-05-01 | 2010-11-04 | Dow Agrosciences Llc | Safening penoxsulam herbicide injury in water-seeded, direct-seeded and transplanted paddy rice |
| CN102187860A (en) * | 2010-11-22 | 2011-09-21 | 南通联农农药制剂研究开发有限公司 | Water dispersible tablet and its preparation method |
| CN103348975A (en) * | 2012-08-22 | 2013-10-16 | 安阳市全丰农药化工有限责任公司 | Choline chloride water dispersible granule/tablet and preparation method thereof |
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Application publication date: 20150401 |
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