CN104448351A - Simplified preparation method of polyurethane hydrogel - Google Patents
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Abstract
The invention discloses a simplified preparation method of polyurethane hydrogel. The method comprises the following steps: heating and warming 40-60 parts of hydrophilic polyester polyol or hydrophilic polyether polyol to 90-125 DEG C, adding 2-3 parts of a chain extender to the hydrophilic polyester polyol or the hydrophilic polyether polyol, dehydrating the mixture of the chain extender and the hydrophilic polyester polyol or the mixture of the chain extender and the hydrophilic polyether polyol, and cooling the dehydrated mixture of the chain extender and the hydrophilic polyester polyol or the mixture of the chain extender and the hydrophilic polyether polyol to 25-60 DEG C; adding the dehydrated hydrophilic polyester polyol or hydrophilic polyether polyol to 10-30 parts of polyisocyanate, carrying out reaction at the temperature of 75-100 DEG C for 2-4 hours, and carrying out vacuum defoaming in a vacuum manner so as to obtain polyurethane prepolymer; then directly dissolving the polyurethane prepolymer in a fitting organic solvent so as to form organogel, and finally replacing the organic solvent with deionized water so as to obtain the polyurethane hydrogel. According to the method disclosed by the invention, the step that polyurethane elastomers must be synthetized firstly in the traditional preparation process of the polyurethane hydrogel is simplified, time for preparing the polyurethane hydrogel is greatly shortened, the transparency of the obtained polyurethane hydrogel is good, and the mechanical strength is high.
Description
Technical field
The present invention relates to polyurethane hydrogel field, particularly relate to a kind of preparation method of polyurethane hydrogel of simplification.
Background technology
Containing a large amount of carbamate segment repeated in urethane (PU) structure, its macromolecular main chain is soft section and polyisocyanates being made up of oligomer polyol and the small molecule chain extender hard section block that forms.By selecting structure and the ratio thereof of suitable soft section and hard section, can the physical and mechanical properties of regulation and control urethane and other performance effectively.In the macromolecular chain of urethane, because the polarity of hard section is strong, mutual magnetism is large, and hard section and soft section thermodynamically have the tendency be spontaneously separated.Therefore, segmented polyurethane easily flocks together, be distributed in soft section mutually in, formed micro phase separation structure.The physical property of this microphase-separated of urethane just, makes it have the characteristic such as physical and mechanical properties, anticoagulant property, biocompatibility being better than other macromolecular materials.
Hydrogel is that a class has tridimensional network, can be water-swellable but water-fast polymkeric substance.It is swelling to balance volume in water, still can keep original structural form.Polyurethane hydrogel has the advantage of urethane and hydrogel concurrently, is widely used in biomedical sector, as: drug release carrier, contact lens, tissue bulking material, Wound dressing, medical treatment transducer etc.At present, the method for polyurethane hydrogel is prepared and the comparatively close prior art of the present invention is as described below:
Chinese invention patent application CN 103524697 A discloses " a kind of polyurethane-urea hydrogel and preparation method thereof ", this preparation method adds vulcabond and catalyst reaction in the solvent being dissolved with polyoxyethylene glycol, add diamines chain extension postprecipitation again and obtain product, after gained solid product dissolves and dries in a solvent, obtain polyurethane hydrogel through swelling.
Chinese invention patent application CN 102604032 A discloses " polyurethane hydrogel of a temperature sensitive chainextender and temperature, pH sensitive ", this preparation method utilizes polyoxyethylene glycol, multi-hydroxy carboxy acid, multicomponent isocyanate and catalyst dibutyltin dilaurylate first to carry out prepolymerization reaction, stop obtaining performed polymer by organic solvent, add temperature sensitive chainextender, polyhydric alcohol amine end-capping reagent and cure-crosslinking agent more successively and obtain polyurethane elastomer, after swelling 1 week, obtain polyurethane hydrogel.
Preparation method disclosed in above technology be all utilize vulcabond and polyoxyethylene glycol to react after base polyurethane prepolymer for use as, after polymerization, solidification, polyurethane elastomer is obtained, subsequently by elastomerics swelling formation polyurethane hydrogel in water again with small molecule chain extender or linking agent.The preparation process of these class methods is comparatively loaded down with trivial details, consuming time longer.
Summary of the invention
Loaded down with trivial details in order to solve above-mentioned technology preparation process, the problem of length consuming time, the invention provides a kind of consuming time short, reaction is all at room temperature carried out, the preparation method of the polyurethane hydrogel that method is easy.
In the organic solvent that the present invention selects base polyurethane prepolymer for use as to be directly dissolved in polarity, specific inductivity is suitable for, the gel of swelling equilibrium in this organic solvent can be obtained in several minutes, then obtain polyurethane hydrogel through the displacement of deionized water.The simplification of this preparation process, can shorten the preparation time of polyurethane hydrogel greatly, and reaction is all at room temperature carried out, and simple to operate, condition is easily controlled, and can implement without the need to special solidification drying plant; Other any solvents are not added, without the need to carrying out any aftertreatment and purge process can use in polyurethane prepolymer production procedure.The prepared polyurethane hydrogel transparency is high, and synthetic method is simple, and can have excellent physical and mechanical properties.
The object of the invention is achieved through the following technical solutions:
A preparation method for the polyurethane hydrogel of simplification, comprises the steps:
1) synthesis of base polyurethane prepolymer for use as: in massfraction, 40 ~ 60 parts of hydrophilic polyesters polyvalent alcohols or hydrophilic polyether polyvalent alcohol are heated to 90 ~ 125 DEG C, and add 2 ~ 3 parts of chainextenders, vacuum tightness remains between 0.04 ~ 0.08MPa, dehydration, places and makes its temperature drop to 25 ~ 60 DEG C; Hydrophilic polyesters polyvalent alcohol after dehydration or the gradation of hydrophilic polyether polyvalent alcohol are joined in 10 ~ 30 parts of polyisocyanates, 5 ~ 40 minutes, feed time interval; Add rear control temperature to react 2 ~ 4 hours at 75 ~ 100 DEG C, vacuum defoamation, sealing saves backup; Controlling isocyanate group mass content in reaction product is 0.2510 ~ 7.6818g/100g, and volumetric molar concentration is 0.0060 ~ 0.1829mol/100g; Described chainextender be 1,4 ?butyleneglycol, glycol ether, TriMethylolPropane(TMP), ethylene glycol, glycerol, 1,4 ?cyclohexanediol, one or more in Resorcinol hydroxy ethers; Described hydrophilic polyesters polyvalent alcohol or the molecular-weight average of hydrophilic polyether polyvalent alcohol are 800 to 10000g/mol;
2) preparation of polyurethane hydrogel: joined by base polyurethane prepolymer for use as in organic solvent, stirs until dissolve completely, leaves standstill 0.5 ~ 24 hour; Formed after organogel until it, joined in deionized water and replace organic solvent, and change deionized water 1 ~ 5 time, can polyurethane hydrogel be obtained; Described organic solvent be N, N ?dimethyl formamide, N, N ?one or more in N,N-DIMETHYLACETAMIDE, dimethyl sulfoxide (DMSO), acetonitrile, ethylene glycol, methyl alcohol, acetone, pyridine, Virahol, propyl alcohol and propyl carbinol.
For realizing the object of the invention further, preferably, described polyisocyanates is isophorone diisocyanate (IPDI), 1,6 ?hexamethylene diisocyanate (HDI), tolylene diisocyanate (TDI), Er Ben base Jia Wan ?4,4 ′ ?vulcabond (MDI), xylylene diisocyanate, Methylcyclohexyl diisocyanate, tetramethylxylylene diisocyanate, IPDI tripolymer, HDI tripolymer, any one or more in TDI tripolymer Black people MDI tripolymer.
Described hydrophilic polyesters polyvalent alcohol or hydrophilic polyether polyvalent alcohol be polytetrahydrofuran diol, polyethylene glycol adipate glycol, poly-adipate glycol Zhi ?1,4 ?one or more in butanediol ester glycol, polyoxyethylene glycol and poly-hexanodioic acid Viscotrol C ester polyol.
In massfraction, the consumption of described organic solvent is 20 ~ 100 parts.
The time of described dehydration is 2.5 ~ 3 hours.
Described standing be that mixed solution is transferred in glass test tube, square, rectangle, cylindrical or spherical vessel.
Polyurethane gle swelling is in organic solvent placed in deionized water when replacing organic solvent, changes a deionized water every 1 ~ 3 hour.
Adopt the mass content of isocyanate group in Di-n-Butyl Amine titration measuring performed polymer.
Hydrophilic polyesters polyvalent alcohol after described dehydration or hydrophilic polyether polyvalent alcohol divide and join for 2 ~ 10 times in 10 ~ 30 parts of polyisocyanates.
Relative to prior art, the present invention has the following advantages:
One, the preparation process of this polyurethane hydrogel is simple, only base polyurethane prepolymer for use as directly need be dissolved in organic solvent, gel can be formed in several minutes, eliminate base polyurethane prepolymer for use as in traditional preparation methods and need experience the process being solidified into polyurethane elastomer, simplify experimental installation and operation steps, and preparation process is all at room temperature carried out, easy to operation, condition is easily controlled, and substantially reduces the reaction times, has important using value;
Two, in base polyurethane prepolymer for use as building-up process without the need to adding any solvent, linking agent, solidifying agent, gained base polyurethane prepolymer for use as can directly use without the need to aftertreatment and purge process, simple to operate;
Three, prepared polyurethane hydrogel has the physical and mechanical properties of high transparent and excellence.
Accompanying drawing explanation
Fig. 1 is the infared spectrum of the base polyurethane prepolymer for use as that embodiment 1 obtains.
Fig. 2 is the infared spectrum of the polyurethane hydrogel that embodiment 1 obtains.
Fig. 3 (a) is the photo of the original-shape with the obtained polyurethane hydrogel of the embodiment 1 of camera shooting.
The photo of the change in shape of polyurethane hydrogel after carrying out simple compression that Fig. 3 (b) obtains for the reflection embodiment 1 of taking with camera.
Fig. 3 (c) is carrying out simple compression experiment for the polyurethane hydrogel that the reflection embodiment 1 with camera shooting is obtained, removes the photo of the shape recovery situation after external force.
Fig. 4 is the stress-strain curve of the Elongation test of the polyurethane hydrogel that embodiment 1 obtains.
Embodiment
For understanding the present invention better, below in conjunction with drawings and Examples, the present invention is further illustrated, but embodiments of the present invention are not limited thereto.
Embodiment 1
(1) 60 parts of polytetrahydrofuran diols are first joined in 250mL there-necked flask, are heated to 125 DEG C by the synthesis of base polyurethane prepolymer for use as: in massfraction; Add 2 part 1,4 ?chain expansion of succinic acid agent, vacuum tightness remains on 0.08MPa, dewaters after 3 hours, place make its temperature drop to 25 DEG C; Polytetrahydrofuran diol after dehydration is divided and joins for 2 times in the isophorone diisocyanate of 10 parts, 40 minutes, 2 feed time intervals; Add rear control temperature to react 2 hours at 100 DEG C, adopt the mass content of-N=C=O in Di-n-Butyl Amine titration measuring performed polymer; When actual measured value is close to theoretical value, vacuum defoamation, sealing saves backup.After testing, isocyanate group mass content is 0.2510g/100g, and volumetric molar concentration is 0.0060mol/100g.
(2) preparation of polyurethane hydrogel: in massfraction, 1 part of base polyurethane prepolymer for use as is joined 100 parts of N, N ?in dimethyl formamide, stirring until to dissolving completely, mixed solution is transferred in glass test tube or cuboid container, leaving standstill 0.5 hour; Formed after organogel until it, joined in deionized water and replace N, N ?dimethyl formamide, and change deionized water 5 times, the interval time changing deionized water is 1 hour, can obtain polyurethane hydrogel.
Fig. 1 is the infared spectrum of the base polyurethane prepolymer for use as that this embodiment 1 obtains.Fig. 2 is the infared spectrum of the polyurethane hydrogel that this embodiment 1 obtains.The contrast infared spectrum (Fig. 1) of base polyurethane prepolymer for use as and the infared spectrum (Fig. 2) of polyurethane hydrogel can be found out, in the structure of base polyurethane prepolymer for use as and polyurethane hydrogel, have all occurred 1715cm
-1carbonylic stretching vibration peak in place's carbamate groups and 1109cm
-1locate the principal character absorption peak of the urethane such as the C – O – C stretching vibration peak of soft section.Difference is, base polyurethane prepolymer for use as with-N=C=O end-blocking, at 2266cm
-1there is the stretching vibration peak of isocyano in place, and in the infrared spectra of polyurethane hydrogel, the stretching vibration peak of isocyano disappears, 1643cm
-1having there is the formation vibration peak of N-H key in place, the isocyano in base polyurethane prepolymer for use as and amino complete reaction is described, defines cross-linked network structure.
Utilize the original-shape of the polyurethane hydrogel obtained by camera shooting, obtain the photo as shown in Fig. 3 (a); This hydrogel sample is placed a sheet glass, by the mode of pressurizeing to this sheet glass, downward reactive force is applied to obtained polyurethane hydrogel, carry out simple compression experiment with this.Downward reactive force is being applied to obtained polyurethane hydrogel, when making it reach maximum deformation quantity, is being subject to the photo of the change in shape after stress with camera shooting this polyurethane hydrogel sample of reflection obtained as shown in Fig. 3 (b); Remove external force, and sheet glass is removed, make polyurethane hydrogel clear-cutting forestland, then take the photo obtained as shown in Fig. 3 (c) with camera.As can be seen from the figure, made polyurethane hydrogel presents the oval column as shown in Fig. 3 (a), carrying out in simple compression experimentation, due to the existence of external force, it is forced to present oblate column as shown in Fig. 3 (b), after removing external force, polyurethane hydrogel clear-cutting forestland, finally presents the oval column of its original form similar as shown in Fig. 3 (c).Therefore, obtained polyurethane hydrogel, after bearing external force, still has and recovers elastically-deformable ability, this also illustrates this polyurethane hydrogel and have good toughness.In addition, utilize PST type electronic tensile machine to carry out Elongation test to obtained polyurethane hydrogel, obtain stress-strain curve as shown in Figure 4.As can be seen from Figure 4, the elongation at break of obtained polyurethane hydrogel is greater than 600%, and tensile strength is higher than 130KPa, and the mechanical strength of this and current other reported polyurethane hydrogel is similar, has excellent physical and mechanical properties.
Ultraviolet-visible spectrophotometer is utilized to carry out transmittance test to prepared polyurethane hydrogel, using deionized water as reference solution, the transmittance of prepared polyurethane hydrogel can reach more than 90%, and therefore, prepared polyurethane hydrogel has high transparent.
The present embodiment is visible, in base polyurethane prepolymer for use as building-up process, without the need to adding any solvent, linking agent, solidifying agent; And gained base polyurethane prepolymer for use as can directly use without the need to aftertreatment and purge process.According to current report, the preparation of polyurethane hydrogel is all after first obtaining base polyurethane prepolymer for use as, then with small molecule chain extender or linking agent through being polymerized, solidify after obtain polyurethane elastomer, subsequently that elastomerics is swelling and to be formed in water.Polymerization process wherein, solidification process need a few hours, tens of hours or even a couple of days respectively; And the present invention is owing to simplifying the process of base polyurethane prepolymer for use as being carried out subsequent disposal, can just form organogel within half an hour the soonest, and just can obtain polyurethane hydrogel within a few hours, substantially reduce the reaction times.
Embodiment 2
(1) 40 parts of poly-hexanodioic acid Viscotrol C ester polyols are first joined in 250mL there-necked flask, are heated to 125 DEG C by the synthesis of base polyurethane prepolymer for use as: in massfraction; Add 2.5 parts of glycerol chainextenders, vacuum tightness remains on 0.06MPa, dewaters after 2.5 hours, places and makes its temperature drop to 25 DEG C; Polyoxyethylene glycol after dehydration is divided and joins for 8 times in 30 parts of HDI tripolymers, 10 minutes, 8 feed time intervals; Add rear control temperature to react 3 hours at 80 DEG C, adopt the mass content of-N=C=O in Di-n-Butyl Amine titration measuring performed polymer; When actual measured value is close to theoretical value, vacuum defoamation, sealing saves backup.Isocyanate group mass content is 0.9896g/100g, and volumetric molar concentration is 0.0236mol/100g;
(2) 5 parts of base polyurethane prepolymer for use as are joined in 50 parts of propyl carbinols, are stirred to and dissolve completely by the preparation of polyurethane hydrogel: in massfraction, are transferred to by mixed solution in glass test tube or square container, leave standstill 24 hours; Formed after organogel until it, joined in deionized water and replace propyl carbinol, and change deionized water 5 times, the interval time changing deionized water is 2 hours, can obtain polyurethane hydrogel.The infared spectrum of the base polyurethane prepolymer for use as that this embodiment obtains is consistent with Fig. 1, Fig. 2 with the infared spectrum of obtained polyurethane hydrogel, no longer repeats.
Embodiment 3
(1) 50 parts of polyethylene glycol adipate glycol are first joined in 250mL there-necked flask, stir, are heated to 100 DEG C by the synthesis of base polyurethane prepolymer for use as: in massfraction; Add 2 parts of TriMethylolPropane(TMP) chainextenders, vacuum tightness remains on 0.04MPa, dewaters after 2.5 hours, places and makes its temperature drop to 60 DEG C; Polyethylene glycol adipate glycol after dehydration is divided join for 3 times 20 parts 1,6 ?in hexamethylene diisocyanate, 20 minutes, 3 feed time intervals; Add rear control temperature to react 3 hours at 80 DEG C, adopt the mass content of-N=C=O in Di-n-Butyl Amine titration measuring performed polymer; When actual measured value is close to theoretical value, vacuum defoamation, sealing saves backup.Isocyanate group mass content is 3.4860g/100g, and volumetric molar concentration is 0.0830mol/100g.
(2) 10 parts of base polyurethane prepolymer for use as are joined in 80 parts of pyridines by the preparation of polyurethane hydrogel: in massfraction, stirring until to dissolving completely, transferred to by mixed solution in glass test tube or cylindrical container, leaving standstill 2 hours; Formed after organogel until it, joined in deionized water and replace pyridine, and change deionized water 4 times, the interval time changing deionized water is 2 hours, can obtain polyurethane hydrogel.The infared spectrum of the base polyurethane prepolymer for use as that this embodiment obtains is consistent with Fig. 1, Fig. 2 with the infared spectrum of obtained polyurethane hydrogel, no longer repeats.
Embodiment 4
(1) 40 parts of polyoxyethylene glycol are first joined in 250mL there-necked flask, are heated to 90 DEG C by the synthesis of base polyurethane prepolymer for use as: in massfraction; Add 2 parts of ethylene glycol chainextenders, vacuum tightness remains on 0.04MPa, dewaters after 3 hours, places and makes its temperature drop to 60 DEG C; Polyoxyethylene glycol after dehydration is divided and joins for 5 times in 30 parts of Methylcyclohexyl diisocyanates, 30 minutes, 5 feed time intervals; Add rear control temperature to react 4 hours at 75 DEG C, adopt the mass content of-N=C=O in Di-n-Butyl Amine titration measuring performed polymer; When actual measured value is close to theoretical value, vacuum defoamation, sealing saves backup.Isocyanate group mass content is 4.8846g/100g, and volumetric molar concentration is 0.1163mol/100g.
(2) 5 parts of base polyurethane prepolymer for use as are joined in 50 parts of acetonitriles by the preparation of polyurethane hydrogel: in massfraction, stirring until to dissolving completely, transferred to by mixed solution in glass test tube or spherical vessel, leaving standstill 6 hours; Formed after organogel until it, joined in deionized water and replace acetonitrile, and change deionized water 3 times, the interval time changing deionized water is 3 hours, can obtain polyurethane hydrogel.The infared spectrum of the base polyurethane prepolymer for use as that this embodiment obtains is consistent with Fig. 1, Fig. 2 with the infared spectrum of obtained polyurethane hydrogel, no longer repeats.
Embodiment 5
(1) synthesis of base polyurethane prepolymer for use as: in massfraction, first by 40 parts of poly-adipate glycol Zhi ?1,4 ?butanediol ester glycol join in 250mL there-necked flask, stir, be heated to 100 DEG C; Add 2 parts of glycol ether chainextenders, vacuum tightness remains on 0.05MPa, dewaters after 3 hours, places and makes its temperature drop to 50 DEG C; By the poly-adipate glycol Zhi after dehydration ?1,4 ?butanediol ester glycol divide join 18 parts for 7 times Er Ben base Jia Wan ?4,4 ′ ?in vulcabond, 15 minutes, 7 feed time intervals; Add rear control temperature to react 3 hours at 85 DEG C, adopt the mass content of-N=C=O in Di-n-Butyl Amine titration measuring performed polymer.When actual measured value is close to theoretical value, vacuum defoamation, sealing saves backup.Isocyanate group mass content is 6.8082g/100g, and volumetric molar concentration is 0.1621mol/100g.
(2) 5 parts of base polyurethane prepolymer for use as are joined in 30 parts of acetone by the preparation of polyurethane hydrogel: in massfraction, stirring until to dissolving completely, transferred to by mixed solution in glass test tube or square container, leaving standstill 12 hours; Formed after organogel until it, joined in deionized water and replace acetone, and change deionized water 2 times, the interval time changing deionized water is 3 hours, can obtain polyurethane hydrogel.The infared spectrum of the base polyurethane prepolymer for use as that this embodiment obtains is consistent with Fig. 1, Fig. 2 with the infared spectrum of obtained polyurethane hydrogel, no longer repeats.
Embodiment 6
(1) 60 parts of polyoxyethylene glycol are first joined in 250mL there-necked flask, are heated to 115 DEG C by the synthesis of base polyurethane prepolymer for use as: in massfraction; Add 3 part 1,4 ?cyclohexanediol chainextender, vacuum tightness remains on 0.07MPa, dewaters after 2.5 hours, place make its temperature drop to 40 DEG C; Polyoxyethylene glycol after dehydration is divided and joins for 10 times in 30 parts of tolylene diisocyanates, 5 minutes, 10 feed time intervals; Add rear control temperature to react 3.5 hours at 80 DEG C, adopt the mass content of-N=C=O in Di-n-Butyl Amine titration measuring performed polymer; When actual measured value is close to theoretical value, vacuum defoamation, sealing saves backup.Isocyanate group mass content is 7.6818g/100g, and volumetric molar concentration is 0.1829mol/100g;
(2) 3 parts of base polyurethane prepolymer for use as are joined in 20 parts of dimethyl sulfoxide (DMSO), are stirred to and dissolve completely by the preparation of polyurethane hydrogel: in massfraction, are transferred to by mixed solution in glass test tube or cuboid container, leave standstill 24 hours; Formed after organogel until it, joined in deionized water and replace dimethyl sulfoxide (DMSO), and change deionized water 1 time, the interval time changing deionized water is 3 hours, can obtain polyurethane hydrogel.The infared spectrum of the base polyurethane prepolymer for use as that this embodiment obtains is consistent with Fig. 1, Fig. 2 with the infared spectrum of obtained polyurethane hydrogel, no longer repeats.
Claims (9)
1. a preparation method for the polyurethane hydrogel simplified, is characterized in that comprising the steps:
1) synthesis of base polyurethane prepolymer for use as: in massfraction, 40 ~ 60 parts of hydrophilic polyesters polyvalent alcohols or hydrophilic polyether polyvalent alcohol are heated to 90 ~ 125 DEG C, and add 2 ~ 3 parts of chainextenders, vacuum tightness remains between 0.04 ~ 0.08MPa, dehydration, places and makes its temperature drop to 25 ~ 60 DEG C; Hydrophilic polyesters polyvalent alcohol after dehydration or the gradation of hydrophilic polyether polyvalent alcohol are joined in 10 ~ 30 parts of polyisocyanates, 5 ~ 40 minutes, feed time interval; Add rear control temperature to react 2 ~ 4 hours at 75 ~ 100 DEG C, vacuum defoamation, sealing saves backup; Controlling isocyanate group mass content in reaction product is 0.2510 ~ 7.6818g/100g, and volumetric molar concentration is 0.0060 ~ 0.1829mol/100g; Described chainextender be 1,4 ?butyleneglycol, glycol ether, TriMethylolPropane(TMP), ethylene glycol, glycerol, 1,4 ?cyclohexanediol, one or more in Resorcinol hydroxy ethers; Described hydrophilic polyesters polyvalent alcohol or the molecular-weight average of hydrophilic polyether polyvalent alcohol are 800 to 10000g/mol;
2) preparation of polyurethane hydrogel: joined by base polyurethane prepolymer for use as in organic solvent, stirs until dissolve completely, leaves standstill 0.5 ~ 24 hour; Formed after organogel until it, joined in deionized water and replace organic solvent, and change deionized water 1 ~ 5 time, can polyurethane hydrogel be obtained; Described organic solvent be N, N ?dimethyl formamide, N, N ?one or more in N,N-DIMETHYLACETAMIDE, dimethyl sulfoxide (DMSO), acetonitrile, ethylene glycol, methyl alcohol, acetone, pyridine, Virahol, propyl alcohol and propyl carbinol.
2. according to the preparation method of the polyurethane hydrogel of simplification according to claim 1, it is characterized in that, described polyisocyanates is isophorone diisocyanate, 1,6 ?hexamethylene diisocyanate, tolylene diisocyanate, Er Ben base Jia Wan ?4,4 ′ ?any one or more in vulcabond, xylylene diisocyanate, Methylcyclohexyl diisocyanate, tetramethylxylylene diisocyanate, IPDI tripolymer, HDI tripolymer, TDI tripolymer and MDI tripolymer.
3. according to the preparation method of the polyurethane hydrogel of simplification according to claim 1, it is characterized in that, described hydrophilic polyesters polyvalent alcohol or hydrophilic polyether polyvalent alcohol be polytetrahydrofuran diol, polyethylene glycol adipate glycol, poly-adipate glycol Zhi ?1,4 ?one or more in butanediol ester glycol, polyoxyethylene glycol and poly-hexanodioic acid Viscotrol C ester polyol.
4. according to the preparation method of the polyurethane hydrogel of simplification according to claim 1, it is characterized in that, in massfraction, the consumption of described organic solvent is 20 ~ 100 parts.
5. according to the preparation method of the polyurethane hydrogel of simplification according to claim 1, it is characterized in that, the time of described dehydration is 2.5 ~ 3 hours.
6., according to the preparation method of the polyurethane hydrogel of the simplification described in claims 1, it is characterized in that, described standing be that mixed solution is transferred in glass test tube, square, rectangle, cylindrical or spherical vessel.
7. according to the preparation method of the polyurethane hydrogel of the simplification described in claims 1, it is characterized in that, polyurethane gle swelling is in organic solvent placed in deionized water when replacing organic solvent, changes a deionized water every 1 ~ 3 hour.
8. according to the preparation method of the polyurethane hydrogel of the simplification described in claims 1, it is characterized in that, adopt the mass content of isocyanate group in Di-n-Butyl Amine titration measuring performed polymer.
9. according to the preparation method of the polyurethane hydrogel of the simplification described in claims 1, it is characterized in that, the hydrophilic polyesters polyvalent alcohol after described dehydration or hydrophilic polyether polyvalent alcohol divide and join for 2 ~ 10 times in 10 ~ 30 parts of polyisocyanates.
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