CN104447760A - Preparation method of epinastine - Google Patents
Preparation method of epinastine Download PDFInfo
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- CN104447760A CN104447760A CN201410689522.7A CN201410689522A CN104447760A CN 104447760 A CN104447760 A CN 104447760A CN 201410689522 A CN201410689522 A CN 201410689522A CN 104447760 A CN104447760 A CN 104447760A
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- organic layer
- sodium hydroxide
- water
- epinastine
- dichloromethane solution
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- 0 *CCC(c1ccccc1C1)Nc2c1cccc2 Chemical compound *CCC(c1ccccc1C1)Nc2c1cccc2 0.000 description 2
- CVZOMMAVGUKDRH-UHFFFAOYSA-N CCC(c1c(C2)cccc1)N(C)c1c2cccc1 Chemical compound CCC(c1c(C2)cccc1)N(C)c1c2cccc1 CVZOMMAVGUKDRH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention discloses a preparation method of epinastine. The preparation method comprises the following steps: using 6-aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepine (E)-2-butenedioate as a raw material, reacting with sodium hydroxide to obtain 6-(aminomethy)-6,11-dihydrodibenzoazepine, then reacting with bromine cyanide, and reacting with N-methylbenzylamine so as to obtain the epinastine. The epinastine prepared through the preparation method is good in quality, high in yield, simple in preparation method, less in energy consumption and low in cost.
Description
Technical field
The present invention relates to a kind of preparation method of pharmaceutical raw material, specifically a kind of preparation method of epinastine.
Background technology
Epinastine, amino-9,13-dihydro-1H-dibenzo [c, f] imidazo [1, the 5-a] azatropylidenes of Chinese another name: 3-, molecular formula: C16H15N3.The orally active antihistaminic of one that Epinastine Hydrochloride (C16H15N3HCl) is succeeded in developing by German Boehringer Ingelheim company, with the Japan three further joint development market of pharmacy cooperation altogether, within 1994, in Japanese Initial Public Offering, commodity are called " Alesion ".Epinastine Hydrochloride is used for the treatment of bronchial asthma, allergic dermatitis, urticaria, eczema, dermatitis and Psoriasis vulgaris (psoriasis), for the bronchoconstriction caused by histamine and bradykinin, there is very strong restraining effect, then not having restraining effect to the bronchoconstriction caused by other chemical mediators, is that most useful effect is in one of perineural histamine H 1 receptor antagonist without sedative effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of preparation method of epinastine, and its synthetic method is simple, and yield is high.
Technical scheme of the present invention is:
A preparation method for epinastine, comprises the steps:
(1), first by water, sodium hydroxide and 6-aminomethyl-6,11-dihydro-5H-dibenzo [b, e] azatropylidene fumarate puts in reaction vessel in order successively, and then adding methylene dichloride, stirring reaction 8 hours at 22-23 DEG C, reaction terminates rear standing separatory, be separated organic layer, then organic layer is dry, obtains the dichloromethane solution of 6-(aminomethyl)-6,11-dihydro-dibenzo azatropylidene;
(2), the dichloromethane solution of bromination nitrile is joined in reaction flask and is then cooled to less than-5 DEG C, keep Nei Wen-8--7 DEG C, the 6-(aminomethyl)-6 that slow dropping step (1) obtains, the dichloromethane solution of 11-dihydro-dibenzo azatropylidene, keep this thermotonus 8 hours, after completion of the reaction, in keeping, temperature is below 25 DEG C, drip N-methylbenzylamine, after keep 38-42 DEG C reflux 45 minutes, normal pressure concentrates, then in system, toluene is added, water, the sodium hydroxide solution that sodium hydroxide is made into, keep 60-70 DEG C of stirring reaction 1.5 hours, reaction terminates rear reaction solution and cools at 3-4 DEG C, crystallize out, filter, washing, obtain wet product,
(3), by the wet product that step (2) obtains join in chloroform and dissolve, separate organic layer, then add chloroform, merge organic layer, organic layer is at 70 DEG C of concentrating under reduced pressure, and the residue obtained adds toluene, keeps less than 70 DEG C and is evaporated to dry, add toluene again, 63-67 DEG C of heating, within about 1.5 hours, dissolve maturation, cooling crystallization at keeping 3.5 DEG C, filtration obtains wet product, obtains epinastine product finally by normal heptane washing, drying under reduced pressure.
Water in described step (1), sodium hydroxide and 6-aminomethyl-6, the mass ratio of 11-dihydro-5H-dibenzo [b, e] azatropylidene fumarate is 6-6.1:0.35-0.36:1; The middle concrete steps being separated organic layer of described step (1) are continue to add methylene dichloride in the water layer after standing separatory, stir after 15 minutes, leave standstill 45 minutes, separate organic layer, merge the organic layer of twice, the organic layer of merging adds water and sodium hydroxide washing, stratification, the organic layer separated continues to add water, NaCl, separates organic layer; Dry employing anhydrous magnesium sulfate drying in described step (1).
The dichloromethane solution of bromination nitrile selects mass percent to be the dichloromethane solution of 6.7% bromination nitrile in described step (2); In described step (2), the mass ratio of the dichloromethane solution of the dichloromethane solution of 6.7% bromination nitrile, N-methylbenzylamine, sodium hydroxide solution and 6-(aminomethyl)-6,11-dihydro-dibenzo azatropylidene is 7.4-7.5: 0.28-0.32: 9.6-9.7: 1; In the sodium hydroxide solution that in described step (2), toluene, water, sodium hydroxide are made into, the mass ratio of toluene, water, sodium hydroxide is 13-13.5: 9.9-10: 1.
Advantage of the present invention:
A kind of epinastine quality prepared by the present invention is good, and yield is high, and preparation method is simple, and less energy consumption, cost is low.
Embodiment
A preparation method for epinastine, comprises the steps:
(1), first by 906 g water, 53.1 g sodium hydroxide and 150 g 6-aminomethyl-6, 11-dihydro-5H-dibenzo [b, e] azatropylidene fumarate DAF puts in reaction vessel in order successively, and then add 802 g methylene dichloride, stirring reaction 8 hours at 22-23 DEG C, reaction terminates rear standing separatory, leave standstill in the water layer after separatory and continue to add 135g methylene dichloride, stir after 15 minutes, leave standstill 45 minutes, separate organic layer, merge the organic layer of twice, the organic layer merged adds 147g water and the washing of 6.1g sodium hydroxide, stratification, the organic layer separated continues to add 137g water, 15.1g NaCl, separate organic layer, then organic over anhydrous dried over mgso, obtain 6-(aminomethyl)-6, the dichloromethane solution of 11-dihydro-dibenzo azatropylidene,
(2), be that the dichloromethane solution of 6.7% bromination nitrile joins in reaction flask and is then cooled to less than-5 DEG C by 730g mass percent, keep Nei Wen-8--7 DEG C, the 6-(aminomethyl)-6 that slow dropping step (1) obtains, the dichloromethane solution of 11-dihydro-dibenzo azatropylidene, keep this thermotonus 8 hours, after completion of the reaction, in keeping, temperature is below 25 DEG C, drip 29.4g N-methylbenzylamine, after keep 38-42 DEG C reflux 45 minutes, normal pressure concentrates, then in system, add toluene (522g), water (390g), NaOH(39.2g) sodium hydroxide solution be made into, keep 60-70 DEG C of stirring reaction 1.5 hours, reaction terminates rear reaction solution and cools at 3-4 DEG C, crystallize out, filter, washing, obtain wet product,
(3), by the wet product that step (2) obtains join in 2469g chloroform and dissolve, separate organic layer, then add 45g chloroform, merge organic layer, organic layer is at 70 DEG C of concentrating under reduced pressure, and the residue obtained adds 170g toluene, keeps less than 70 DEG C and is evaporated to dry, add 543g toluene again, 63-67 DEG C of heating, within about 1.5 hours, dissolve maturation, cooling crystallization at keeping 3.5 DEG C, filtration obtains wet product, obtains epinastine product finally by the washing of 10.2g normal heptane, drying under reduced pressure.
Claims (3)
1. a preparation method for epinastine, is characterized in that, comprises the steps:
(1), first by water, sodium hydroxide and 6-aminomethyl-6,11-dihydro-5H-dibenzo [b, e] azatropylidene fumarate puts in reaction vessel in order successively, and then adding methylene dichloride, stirring reaction 8 hours at 22-23 DEG C, reaction terminates rear standing separatory, be separated organic layer, then organic layer is dry, obtains the dichloromethane solution of 6-(aminomethyl)-6,11-dihydro-dibenzo azatropylidene;
(2), the dichloromethane solution of bromination nitrile is joined in reaction flask and is then cooled to less than-5 DEG C, keep Nei Wen-8--7 DEG C, the 6-(aminomethyl)-6 that slow dropping step (1) obtains, the dichloromethane solution of 11-dihydro-dibenzo azatropylidene, keep this thermotonus 8 hours, after completion of the reaction, in keeping, temperature is below 25 DEG C, drip N-methylbenzylamine, after keep 38-42 DEG C reflux 45 minutes, normal pressure concentrates, then in system, toluene is added, water, the sodium hydroxide solution that sodium hydroxide is made into, keep 60-70 DEG C of stirring reaction 1.5 hours, reaction terminates rear reaction solution and cools at 3-4 DEG C, crystallize out, filter, washing, obtain wet product,
(3), by the wet product that step (2) obtains join in chloroform and dissolve, separate organic layer, then add chloroform, merge organic layer, organic layer is at 70 DEG C of concentrating under reduced pressure, and the residue obtained adds toluene, keeps less than 70 DEG C and is evaporated to dry, add toluene again, 63-67 DEG C of heating, within about 1.5 hours, dissolve maturation, cooling crystallization at keeping 3.5 DEG C, filtration obtains wet product, obtains epinastine product finally by normal heptane washing, drying under reduced pressure.
2. the preparation method of a kind of epinastine according to claim 1, it is characterized in that: the water in described step (1), sodium hydroxide and 6-aminomethyl-6, the mass ratio of 11-dihydro-5H-dibenzo [b, e] azatropylidene fumarate is 6-6.1:0.35-0.36:1; The middle concrete steps being separated organic layer of described step (1) are continue to add methylene dichloride in the water layer after standing separatory, stir after 15 minutes, leave standstill 45 minutes, separate organic layer, merge the organic layer of twice, the organic layer of merging adds water and sodium hydroxide washing, stratification, the organic layer separated continues to add water, NaCl, separates organic layer; Dry employing anhydrous magnesium sulfate drying in described step (1).
3. the preparation method of a kind of epinastine according to claim 1, is characterized in that: the dichloromethane solution of bromination nitrile selects mass percent to be the dichloromethane solution of 6.7% bromination nitrile in described step (2); In described step (2), the mass ratio of the dichloromethane solution of the dichloromethane solution of 6.7% bromination nitrile, N-methylbenzylamine, sodium hydroxide solution and 6-(aminomethyl)-6,11-dihydro-dibenzo azatropylidene is 7.4-7.5: 0.28-0.32: 9.6-9.7: 1; In the sodium hydroxide solution that in described step (2), toluene, water, sodium hydroxide are made into, the mass ratio of toluene, water, sodium hydroxide is 13-13.5: 9.9-10: 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410689522.7A CN104447760A (en) | 2014-11-26 | 2014-11-26 | Preparation method of epinastine |
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| CN201410689522.7A CN104447760A (en) | 2014-11-26 | 2014-11-26 | Preparation method of epinastine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104974164A (en) * | 2015-06-26 | 2015-10-14 | 大连理工大学 | Preparation method of 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine |
| CN115448927A (en) * | 2022-10-20 | 2022-12-09 | 重庆瑞泊莱医药科技有限公司 | Epinastine hydrobromide crystal form II and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002193939A (en) * | 2000-12-26 | 2002-07-10 | Konica Chemical Corp | PRODUCTION METHOD OF 6-AMINOMETHYL-6,11-DIHYDRO-5H- DIBENZ[b,e]AZEPINE |
| KR20020091539A (en) * | 2001-05-31 | 2002-12-06 | 바이오네스트 주식회사 | A Method for the Preparation of Epinastine and a Pharmaceutically Acceptable Salt thereof |
| CN103012408A (en) * | 2012-11-28 | 2013-04-03 | 中国科学院广州生物医药与健康研究院 | Synthesis method of epinastine |
-
2014
- 2014-11-26 CN CN201410689522.7A patent/CN104447760A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002193939A (en) * | 2000-12-26 | 2002-07-10 | Konica Chemical Corp | PRODUCTION METHOD OF 6-AMINOMETHYL-6,11-DIHYDRO-5H- DIBENZ[b,e]AZEPINE |
| KR20020091539A (en) * | 2001-05-31 | 2002-12-06 | 바이오네스트 주식회사 | A Method for the Preparation of Epinastine and a Pharmaceutically Acceptable Salt thereof |
| CN103012408A (en) * | 2012-11-28 | 2013-04-03 | 中国科学院广州生物医药与健康研究院 | Synthesis method of epinastine |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104974164A (en) * | 2015-06-26 | 2015-10-14 | 大连理工大学 | Preparation method of 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine |
| CN104974164B (en) * | 2015-06-26 | 2017-06-27 | 大连理工大学 | A kind of preparation method of 6 aminomethyl 6,11 dihydro 5H dibenzo [b, e] azatropylidene |
| CN115448927A (en) * | 2022-10-20 | 2022-12-09 | 重庆瑞泊莱医药科技有限公司 | Epinastine hydrobromide crystal form II and preparation method thereof |
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Application publication date: 20150325 |