CN104447598A - Ca-4的大环多胺衍生物及其抗肿瘤特性 - Google Patents

Ca-4的大环多胺衍生物及其抗肿瘤特性 Download PDF

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Publication number
CN104447598A
CN104447598A CN 201310428519 CN201310428519A CN104447598A CN 104447598 A CN104447598 A CN 104447598A CN 201310428519 CN201310428519 CN 201310428519 CN 201310428519 A CN201310428519 A CN 201310428519A CN 104447598 A CN104447598 A CN 104447598A
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macrocyclic
polyamine
derivatives
tumor
compounds
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CN 201310428519
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English (en)
Chinese (zh)
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CN104447598B (zh )
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王建平
王建国
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浙江大德药业集团有限公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D255/00Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
CN 201310428519 2013-09-18 2013-09-18 Ca‑4的大环多胺衍生物及其抗肿瘤特性 CN104447598B (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018051197A1 (en) * 2016-09-19 2018-03-22 The Hong Kong Polytechnic University Chiral cyclen compounds and their uses

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1465580A (zh) * 2002-06-07 2004-01-07 深圳市北大高科技股份有限公司 一种简便合成康普立停a-4前药的方法
US20070270617A1 (en) * 2000-09-14 2007-11-22 Venit John J Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts
CN101085743A (zh) * 2006-06-06 2007-12-12 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途
CN101139358A (zh) * 2006-09-07 2008-03-12 浙江大德药业集团有限公司 乙氧基康普立停及其前药的制备和用途
WO2009118474A1 (fr) * 2008-02-28 2009-10-01 Sanofi-Aventis Procede de preparation de combretastatine
CN103012248A (zh) * 2013-01-11 2013-04-03 浙江大德药业集团有限公司 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070270617A1 (en) * 2000-09-14 2007-11-22 Venit John J Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts
CN1465580A (zh) * 2002-06-07 2004-01-07 深圳市北大高科技股份有限公司 一种简便合成康普立停a-4前药的方法
CN101085743A (zh) * 2006-06-06 2007-12-12 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途
CN101139358A (zh) * 2006-09-07 2008-03-12 浙江大德药业集团有限公司 乙氧基康普立停及其前药的制备和用途
WO2009118474A1 (fr) * 2008-02-28 2009-10-01 Sanofi-Aventis Procede de preparation de combretastatine
CN103012248A (zh) * 2013-01-11 2013-04-03 浙江大德药业集团有限公司 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018051197A1 (en) * 2016-09-19 2018-03-22 The Hong Kong Polytechnic University Chiral cyclen compounds and their uses

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