CN104445130B - A kind of mesoporous bata-tricalcium phosphate raw powder's production technology - Google Patents
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Abstract
The present invention relates to a kind of mesoporous beta tricalcium phosphate raw powder's production technology, include following steps: 1) prepare two parts containing surfactant, cosurfactant and the clear solution of water；2) in clear solution, it is separately added into calcic inorganic salt solution and inorganic phosphor-contained saline solution, stirring, in the mixed solution of gained calcic inorganic salt, add the mixed solution of inorganic phosphor-contained salt, regulate pH value, stir to obtain emulsion；3) still aging, centrifugal, washing dried is placed in high temperature furnace, heats up, and insulation obtains mesoporous beta TCP powder body.The beneficial effects of the present invention is: 1, simple to operate, energy consumption is low, low cost, reaction condition is gentle, and preparation process does not produce environmentally harmful material.2, obtained mesoporous beta TCP powder body aperture is less, has three-dimensional open-framework, and its average pore size is 8.80 21.36nm, and specific surface area is 10.11 153.43m2/g。
Description
Technical field
The present invention relates to a kind of mesoporous bata-tricalcium phosphate raw powder's production technology.
Background technology
Ca3(PO4)2[TCP] has the β phase two kinds of megathermal α phase and low form.Wherein β-TCP [β-the Ca of low form3(PO4)2]
Mainly it is made up of calcium, phosphorus, its composition and the inorganic constituents [Ca of bone matrix10(PO4)6(OH)2] similar, there is good biology
The compatibility.Scholar it turned out β-TCP and can be absorbed by body, and NIP or rejection do not produce topically or systemically
Toxic reaction.The degree of hemolysis ＜ 5% of β-TCP；Nontoxic level is belonged to by toxicity metering classification；Thermal source detection bodies temperature rise a large amount ＜ 0.6 DEG C.
β-TCP can with osseous tissue directly in conjunction with, do not have fibrous tissue to grow between the two.After β-TCP implants osseous tissue, in its interface shape
Become the solid-liquid equilibria of a kind of calcium phosphorus.Maintain the ion of this balance from the osseous tissue of surrounding and embedded material.These calcium phosphorus from
Son " medium " finally forms calcium phosphorus solid with the form of biological apatite and is deposited on interface, and formation β-TCP is direct with bone
In conjunction with or synostosis.β-TCP is mainly used in treating face and the Cranial defect in jaw portion clinically, fill up periodontal cavity and
Tendon artificial with organic or inorganic produced with combination and complex bone plate, be alternatively arranged as the carrier of medicine.Along with going deep into of research, various
β-TCP the material of form shows excellent performance in orthopaedics is applied.Compare with HA (hydroxyapatite), β-TCP simultaneously
Being easier to degradation in vivo, its dissolubility is about high 10-20 times than HA, and their physiological property is without substantially difference, makes
Obtain β-TCP in the fields such as organizational project, obtain use widely.
Mesoporous material refers to the aperture porous material in 2-50nm scope, because it has the bigger inner surface allowing molecule to enter
With hole, there are many excellent performances such as unusual physics, chemistry because of quantum size effect and the impact of interface coupling effect,
Huge potential application foreground will be had at numerous areas such as chemistry, optoelectronics, electromagnetism, materialogy, environmentologys.Mesoporous material
Material has the features such as higher specific surface area, regular pore passage structure, narrow pore-size distribution, pore size continuously adjustabe,
It is made to play an important role at aspects such as pharmaceutical carrier, protein adsorption, catalysis.β-TCP have good biocompatibility,
Biological activity and biological degradability, be preferable human body hard tissue reparation and substitution material, always technical field of biological material research
Focus.But mesoporous beta-TCP has no report due to its crystal habit, preparation difficulty.
Summary of the invention
It is an object of the invention to provide a kind of mesoporous bata-tricalcium phosphate powder body preparation method, it is less to prepare aperture, tool
There is the mesoporous beta-TCP powder body of three-dimensional open-framework.
The present invention solves above-mentioned technical problem and be employed technical scheme comprise that, a kind of mesoporous bata-tricalcium phosphate raw powder's production technology,
Include following steps:
1) preparing two parts and contain surfactant, cosurfactant and the clear solution of water, surfactant concentration is
10-100g/L, cosurfactant concentration is 50-250mL/L；
2) to step 1) to be separately added into the calcic inorganic salt that calcium ion concentration is 0.1-1.0mol/L in two parts of clear solutions of gained molten
Liquid and phosphate ion concentration are the inorganic phosphor-contained saline solution of 0.1-1.0mol/L, and stir in 25-90 DEG C, obtain calcic
The mixed solution of inorganic salt and the mixed solution of inorganic phosphor-contained salt, keep temperature-resistant, adds in the mixed solution of calcic inorganic salt
Entering the mixed solution of inorganic phosphor-contained salt so that the element calcium added is 1.5:1 with the mol ratio of phosphorus, regulation pH value is subsequently
6.0-9.0, it is uniformly mixing to obtain emulsion；
3) by step 2) the most still aging 12-48h of gained emulsion, and isolate precipitate by centrifugal method,
Washing dried is placed in high temperature furnace, is warmed up to 750-950 DEG C with the speed of 2-10 DEG C/min under room temperature, is incubated 1-6h
After, obtain mesoporous bata-tricalcium phosphate powder body.
As such scheme: step 1) described in surfactant be cetyl trimethylammonium bromide, polyethers F127,18-amine.,
Sodium lauryl sulphate, dodecylbenzene sodium sulfonate, polyoxyethylene-poly-oxypropylene polyoxyethylene, polyamide-amide, citric acid,
The mixing of any one or more in polyvinylpyrrolidone, Macrogol 2000 and polyethylene glycol 6000.
As such scheme: step 1) described in cosurfactant be n-butyl alcohol, isobutanol, 1-capryl alcohol, sec-n-octyl alcohol, ethanol,
The mixing of any one or more in normal propyl alcohol, isopropanol, n-amyl alcohol, isoamyl alcohol, 1-hexanol, 2-hexanol and n nonylphenol.
As such scheme: step 2) described in calcic inorganic salt be four water-calcium nitrate, calcium chloride, calcium carbonate, calcium sulfate, chlorine
The mixing of any one or more in acid calcium, calcium citrate, calcium hydroxide and calcium oxide.
As such scheme: step 2) described in inorganic phosphor-contained salt be diammonium phosphate, sodium phosphate, sodium dihydrogen phosphate, phosphoric acid hydrogen
Disodium, phosphoric acid, Polymeric sodium metaphosphate., sodium hexameta phosphate, ammonium dihydrogen phosphate, sodium polyphosphate, dipotassium hydrogen phosphate and potassium dihydrogen phosphate
In the mixing of any one or more.
As such scheme: step 3) described in washing dried include using washing 2-3 time, then wash 1-3 with dehydrated alcohol
Secondary, and in 80-120 DEG C of dry 12-24h.
By such scheme, the mesoporous average pore size of described mesoporous bata-tricalcium phosphate powder body is 8.80-21.36nm, and specific surface area is
10.11-153.43m2/g。
The beneficial effects of the present invention is: 1, preparation method of the present invention is simple to operate, and energy consumption is low, low cost, reaction condition temperature
With, preparation process does not produce environmentally harmful material.2, the mesoporous beta-TCP powder obtained by preparation in accordance with the present invention
Body aperture is less, has three-dimensional open-framework, and its average pore size is 8.80-21.36nm, and specific surface area is 10.11-153.43m2/g。
3, the mesoporous beta-TCP that prepared by the present invention not only has the advantage of conventional β-TCP, such as good biocompatibility, biological activity
And biological degradability, it is preferable human body hard tissue reparation and substitution material, and because there is higher specific surface area, have
The features such as the pore passage structure of sequence, narrow pore-size distribution, pore size continuously adjustabe so that it is pharmaceutical carrier, protein adsorption,
The aspects such as catalysis play an important role, and inhale with the purification of nucleic acid, macromole at slow releasing carrier of medication, gene therapy, albumen
The aspects such as attached, bio-medical material have important value.
Accompanying drawing explanation
Fig. 1 is the XRD figure of the mesoporous beta-TCP powder body prepared by the embodiment of the present invention 1；
Fig. 2 is the SEM photograph of the mesoporous beta-TCP powder body prepared by the embodiment of the present invention 1；
Fig. 3 is the SEM photograph of the mesoporous beta-TCP powder body prepared by the embodiment of the present invention 1；
Fig. 4 is the nitrogen adsorption-desorption isotherm of the mesoporous beta-TCP powder body prepared by the embodiment of the present invention 1；
Fig. 5 is the pore size distribution curve figure of the mesoporous beta-TCP powder body prepared by the embodiment of the present invention 1.
Detailed description of the invention
For making those skilled in the art be more fully understood that technical scheme, below in conjunction with the accompanying drawings the present invention is made the most in detail
Thin description.
Embodiment 1
Prepare two parts containing Surfactant CTAB, cosurfactant n-butyl alcohol and the clear solution of water, the wherein volume of water
For 40mL, surfactant concentration is 12.5g/L, and cosurfactant concentration is 100mL/L, then to two parts of clear solutions
In be separately added into the Ca (NO of 0.5mol/L3)2·4H2(the NH of O solution 20mL and 0.5mol/L4)2HPO4Solution, and in 40 DEG C
Stir, obtain mixed solution and the mixed solution of inorganic phosphor-contained salt of calcic inorganic salt, keep temperature-resistant, with
0.1mL speed per minute adds the mixed solution of inorganic phosphor-contained salt in the mixed solution of calcic inorganic salt, and make to be added
Element calcium is 1.5:1 with the mol ratio of phosphorus, uses NH3·H2O solution regulation pH=7.5, continues magnetic agitation 21h, then room temperature
Under still aging 48h, with 10000 revs/min of high speed centrifugation 3min, gained precipitate is first washed three times, then alcohol is washed three times,
After by precipitate in drying baker 80 DEG C dry after 24h, be warming up to 800 DEG C with the programming rate of 5 DEG C/min under room temperature, and
800 DEG C of heat treatment 4h, obtain mesoporous beta-TCP powder sample.
It is illustrated in figure 1 the XRD figure of embodiment of the present invention gained powder sample, the main diffraction peak of sample and the mark of β-TCP
Quasi-collection of illustrative plates is consistent, and shows that the principal crystalline phase of gained powder sample is β-TCP.It can also be seen that the peak width of diffraction maximum is narrower from figure, peak
Line is relatively sharp-pointed, illustrates that the crystallization degree of β-TCP powder body is higher.It is the scanning electricity of β-TCP powder body as shown in Figures 2 and 3
Mirror picture, it can be seen that prepared β-TCP powder body contains three-dimensional open-framework, and pore passage structure is formed by particle packing, powder
Surface be dispersed with comparison orderly be interconnected mesoporous.N from this β-TCP powder body2Adsorption-desorption isothermal (Fig. 4)
It can be seen that β-TCP powder body has IV type adsorption-desorption isothermal and H2 type hysteresis loop, this is the spy of typical case's meso-hole structure
Levying isothermal line, the powder body prepared by explanation is mesoporous beta-TCP, and at P/P0=0.94-0.96 scope has an obvious ladder,
Illustrate that the pore-size distribution of powder sample intermediary hole structure is wider.Can from the graph of pore diameter distribution (Fig. 5) of mesoporous beta-TCP powder body
Go out sample contains the aperture meso-hole structure at 2-50nm, and have a peak value comparing concentration at 2.1nm, but at high-temperature hot
After reason, the specific surface area of the powder sample of gained is less.Full-automatic specific surface area and lacunarity analysis instrument is used to record the average of sample
Aperture is 8.80nm, and specific surface area is 10.11m2/g。
Embodiment 2
Prepare two parts and contain surfactant polyethylene 6000, the clear solution of the pungent alcohol and water of cosurfactant 1-, wherein
The volume of water is 30mL, and surfactant concentration is 10g/L, and cosurfactant concentration is 50mL/L, then to two parts thoroughly
Bright solution is separately added into the CaCl of 0.1mol/L2The NaH of solution 30mL and 0.1mol/L2PO4Solution, and fill in 25 DEG C
Divide and stir, obtain mixed solution and the mixed solution of inorganic phosphor-contained salt of calcic inorganic salt.Keep temperature-resistant, with often
Minute 0.2mL speed adds the mixed solution of inorganic phosphor-contained salt in the mixed solution of calcic inorganic salt, and makes added unit
Element calcium is 1.5:1 with the mol ratio of phosphorus, uses NH3·H2O solution regulation pH=6.0, continues magnetic agitation 2h, then under room temperature
Still aging 12h, with 9500 revs/min of high speed centrifugation 3min, gained precipitate is first washed twice, then alcohol is washed once.Finally will
Precipitate after 120 DEG C of drying 12h, is warming up to 750 DEG C with the programming rate of 2 DEG C/min under room temperature in drying baker, and at 750 DEG C
Heat treatment 6h, obtains mesoporous beta-TCP powder sample.N2Adsorption-desorption isothermal and pore size distribution curve show, it is mesoporous flat
All apertures are 21.36nm, and specific surface area is 153.43m2/g。
Embodiment 3
Prepare two parts and contain the saturating of surfactant polyoxyethylene-polyoxypropylene polyoxyethylene, cosurfactant normal propyl alcohol and water
Bright solution, wherein the volume of water is 200mL, and surfactant concentration is 100g/L, and cosurfactant concentration is 250mL/L,
Then in two parts of clear solutions, it is separately added into the CaSO of 1.0mol/L4The Na of solution 80mL and 1.0mol/L3PO4Solution,
And stir in 90 DEG C, obtain mixed solution and the mixed solution of inorganic phosphor-contained salt of calcic inorganic salt.Keep temperature
Constant, in the mixed solution of calcic inorganic salt, the mixed solution of inorganic phosphor-contained salt is added with 0.6mL speed per minute, and
Making added element calcium is 1.5:1 with the mol ratio of phosphorus, uses NH3·H2O solution regulation pH=9.0, continues magnetic agitation 24h,
Then left at room temperature ageing 24h, with 9000 revs/min of high speed centrifugation 3min, gained precipitate is first washed twice, then alcohol washes two
Secondary.Finally precipitate after 100 DEG C of drying 22h, is warming up to 950 DEG C with the programming rate of 10 DEG C/min under room temperature in drying baker,
And at 950 DEG C of heat treatment 1h, obtain mesoporous beta-TCP powder sample.N2Adsorption-desorption isothermal and pore size distribution curve show,
Its mesoporous average pore size is 20.18nm, and specific surface area is 148.27m2/g。
Embodiment 4
Prepare two parts containing surfactant 18-amine., the clear solution of cosurfactant isobutyl alcohol and water, the wherein volume of water
For 50mL, surfactant concentration is 50g/L, and cosurfactant concentration is 100mL/L, then to two parts of clear solutions
In be separately added into the Ca (Cl0 of 0.3mol/L3)2The NH of solution 30mL and 0.3mol/L4H2PO4Solution, and in 50 DEG C fully
Stir, obtain mixed solution and the mixed solution of inorganic phosphor-contained salt of calcic inorganic salt.Keep temperature-resistant, with every point
Clock 0.4mL speed adds the mixed solution of inorganic phosphor-contained salt in the mixed solution of calcic inorganic salt, and makes added element
Calcium is 1.5:1 with the mol ratio of phosphorus, uses NH3·H2O solution regulation pH=8.0, continues magnetic agitation 20h, then quiet under room temperature
Putting ageing 18h, with 10000 revs/min of high speed centrifugation 3min, gained precipitate is first washed twice, then alcohol washes three times.Finally will
Precipitate after 80 DEG C of drying 22h, is warming up to 900 DEG C with the programming rate of 6 DEG C/min under room temperature in drying baker, and at 900 DEG C
Heat treatment 2h, obtains mesoporous beta-TCP powder sample.N2Adsorption-desorption isothermal and pore size distribution curve show, it is mesoporous flat
All apertures are 18.22nm, and specific surface area is 113.96m2/g。
Embodiment 5
Prepare two parts containing surfactant (sodium lauryl sulphate and polyvinylpyrrolidone), cosurfactant (sec-n-octyl alcohol and
Ethanol) and the clear solution of water, wherein the volume of water is 60mL, and surfactant concentration is 60g/L, and cosurfactant is dense
Degree is 150mL/L, is then separately added into the calcic inorganic salt solution (Ca (OH) of 0.4mol/L in two parts of clear solutions2Solution
The CaO solution 20mL of 20mL and 0.4mol/L) and the inorganic phosphor-contained saline solution (Na of 0.4mol/L2HPO4Solution and 0.4mol/L
Polymeric sodium metaphosphate. solution), and stir in 45 DEG C, obtain the mixed solution of calcic inorganic salt and the mixed of inorganic phosphor-contained salt
Close solution.Keep temperature-resistant, in the mixed solution of calcic inorganic salt, add inorganic phosphor-contained salt with 0.3mL speed per minute
Mixed solution, and to make the mol ratio of added element calcium and phosphorus be 1.5:1, uses NH3·H2O solution regulation pH=8.5,
Continuing magnetic agitation 22h, then left at room temperature ageing 36h, with 8500 revs/min of high speed centrifugation 3min, gained precipitate is first
Wash three times, then alcohol washes twice.Finally by precipitate in drying baker 80 DEG C dry after 24h, with the liter of 7 DEG C/min under room temperature
Temperature speed is warming up to 800 DEG C, and at 800 DEG C of heat treatment 3h, obtains mesoporous beta-TCP powder sample.N2Adsorption-desorption isothermal
Line and pore size distribution curve show, its mesoporous average pore size is 9.01nm, and specific surface area is 13.78m2/g。
Embodiment 6
Prepare two parts containing surfactant (Macrogol 2000 and citric acid), cosurfactant (n-amyl alcohol and 1-hexanol)
With the clear solution of water, wherein the volume of water is 80mL, and surfactant concentration is 80g/L, and cosurfactant concentration is
200mL/L, is then separately added into calcic inorganic salt solution (the calcium citrate solutions 30mL of 0.6mol/L in two parts of clear solutions
CaCO with 0.6mol/L3Solution 30mL) and the inorganic phosphor-contained saline solution (H of 0.6mol/L3PO4Solution and the six of 0.6mol/L
Polymeric sodium metaphosphate. solution), and stir in 60 DEG C, obtain mixed solution and the mixing of inorganic phosphor-contained salt of calcic inorganic salt
Solution.Keep temperature-resistant, in the mixed solution of calcic inorganic salt, add inorganic phosphor-contained salt with 0.5mL speed per minute
Mixed solution, and to make the mol ratio of added element calcium and phosphorus be 1.5:1, uses NH3·H2O solution regulation pH=7.0, continues
Continuous magnetic agitation 18h, then left at room temperature ageing 24h, with 10000 revs/min of high speed centrifugation 3min, gained precipitate elder generation water
Wash three times, then alcohol washes twice.Finally by precipitate in drying baker 110 DEG C dry after 18h, with the liter of 8 DEG C/min under room temperature
Temperature speed is warming up to 800 DEG C, and at 800 DEG C of heat treatment 2h, obtains mesoporous beta-TCP powder sample.N2Adsorption-desorption isothermal
Line and pore size distribution curve show, its mesoporous average pore size is 11.59nm, and specific surface area is 34.66m2/g。
Embodiment 7
Prepare two parts containing surfactant (dodecylbenzene sodium sulfonate, polyamide-amide and polyvinylpyrrolidone), help surface live
Property agent (isopropanol, 2-hexanol and n nonylphenol) and the clear solution of water, wherein the volume of water is 100mL, and surfactant is dense
Degree is 90g/L, and cosurfactant concentration is 220mL/L, is then separately added into calcic inorganic salt in two parts of clear solutions molten
Liquid (Ca (the NO of 0.8mol/L3)2·4H2The CaCl of O solution 20mL, 0.8mol/L2The CaSO of solution 20mL and 0.8mol/L4
Solution 20mL) and the inorganic phosphor-contained saline solution (K of 0.8mol/L2HPO4Solution, the polyphosphoric acids sodium solution of 0.8mol/L and
(the NH of 0.8mol/L4)2HPO4Solution), and stir in 80 DEG C, obtain the mixed solution of calcic inorganic salt and contain
The mixed solution of phosphorus inorganic salt.Keep temperature-resistant, add in the mixed solution of calcic inorganic salt with 0.3mL speed per minute
Enter the mixed solution of inorganic phosphor-contained salt, and to make added element calcium be 1.5:1 with the mol ratio of phosphorus, use NH3·H2O solution
Regulation pH=7.5, continues magnetic agitation 19h, then left at room temperature ageing 24h, with 10000 revs/min of high speed centrifugation 5min,
Gained precipitate is first washed three times, then alcohol is washed once.Finally by precipitate in drying baker 100 DEG C dry after 12h, under room temperature
It is warming up to 850 DEG C with the programming rate of 9 DEG C/min, and at 850 DEG C of heat treatment 4h, obtains mesoporous beta-TCP powder sample.N2
Adsorption-desorption isothermal and pore size distribution curve show, its mesoporous average pore size is 15.31nm, and specific surface area is 58.37m2/g。
Embodiment 8
Prepare two parts containing surfactant (polyethers F127, polyethylene glycol 6000 and CTAB), cosurfactant (isoamyl alcohol,
N-butyl alcohol and 1-capryl alcohol) and the clear solution of water, wherein the volume of water is 150mL, and surfactant concentration is 100g/L, helps
Surfactant concentration is 250mL/L, be then separately added in two parts of clear solutions calcic inorganic salt solution (0.9mol/L's
Ca(NO3)2·4H2The calcium citrate solutions 40mL of O solution 40mL and 0.9mol/L) and inorganic phosphor-contained saline solution (0.9mol/L
KH2PO4Solution, the sodium hexametaphosphate solution of 0.9mol/L and the (NH of 0.9mol/L4)2HPO4Solution), and in 70 DEG C fully
Stir, obtain mixed solution and the mixed solution of inorganic phosphor-contained salt of calcic inorganic salt.Keep temperature-resistant, with every point
Clock 0.5mL speed adds the mixed solution of inorganic phosphor-contained salt in the mixed solution of calcic inorganic salt, and makes added element
Calcium is 1.5:1 with the mol ratio of phosphorus, uses NH3·H2O solution regulation pH=8.0, continues magnetic agitation 24h, then quiet under room temperature
Putting ageing 24h, with 10000 revs/min of high speed centrifugation 3min, gained precipitate is first washed three times, then alcohol washes three times.Finally will
Precipitate after 80 DEG C of drying 24h, is warming up to 800 DEG C with the programming rate of 5 DEG C/min under room temperature in drying baker, and at 800 DEG C
Heat treatment 4h, obtains mesoporous beta-TCP powder sample.N2Adsorption-desorption isothermal and pore size distribution curve show, it is mesoporous flat
All apertures are 14.83nm, and specific surface area is 109.48m2/g。
Obviously, above-described embodiment is only in order to illustrate technical scheme, and not to scope or embodiment
Restriction.For those of ordinary skill in the field, technical scheme can be made other multi-form
Change or variation, here without also giving exhaustive to all of embodiment.And the obvious amendment therefore amplified
Or within equivalent is still in the protection domain of the invention.
Claims (4)
1. a mesoporous bata-tricalcium phosphate raw powder's production technology, includes following steps:
1) preparing two parts and contain surfactant, cosurfactant and the clear solution of water, surfactant concentration is 10-100g/L, and cosurfactant concentration is 50-250mL/L；Described surfactant is the mixing of any one or more in cetyl trimethylammonium bromide, polyethers F127,18-amine., sodium lauryl sulphate, dodecylbenzene sodium sulfonate, polyoxyethylene-poly-oxypropylene polyoxyethylene, polyamide-amide, citric acid, polyvinylpyrrolidone, Macrogol 2000 and polyethylene glycol 6000；
2) in two parts of clear solutions of step 1) gained, the calcic inorganic salt solution that calcium ion concentration is 0.1-1.0mol/L and the inorganic phosphor-contained saline solution that phosphate ion concentration is 0.1-1.0mol/L it are separately added into, and stir in 25-90 DEG C, obtain mixed solution and the mixed solution of inorganic phosphor-contained salt of calcic inorganic salt, keep temperature-resistant, the mixed solution of inorganic phosphor-contained salt is added in the mixed solution of calcic inorganic salt, making added element calcium is 1.5:1 with the mol ratio of phosphorus, regulation pH value is 6.0-9.0 subsequently, is uniformly mixing to obtain emulsion；
null3) by step 2) the most still aging 12-48h of gained emulsion，And isolate precipitate by centrifugal method，Washing dried is placed in high temperature furnace，Described washing dried includes using washing 2-3 time，Wash 1-3 time with dehydrated alcohol again，And in 80-120 DEG C of dry 12-24h，It is warmed up to 750-950 DEG C with the speed of 2-10 DEG C/min under room temperature，After insulation 1-6h，Obtain mesoporous bata-tricalcium phosphate powder body，Described β-TCP powder body contains three-dimensional open-framework，Pore passage structure is formed by particle packing，Powder surface be dispersed with comparison orderly be interconnected mesoporous，The mesoporous average pore size of described mesoporous bata-tricalcium phosphate powder body is 8.80-21.36nm，Specific surface area is 10.11-153.43m2/g。
Mesoporous bata-tricalcium phosphate raw powder's production technology the most according to claim 1, it is characterised in that: the cosurfactant described in step 1) is the mixing of any one or more in n-butyl alcohol, isobutanol, 1-capryl alcohol, sec-n-octyl alcohol, ethanol, normal propyl alcohol, isopropanol, n-amyl alcohol, isoamyl alcohol, 1-hexanol, 2-hexanol and n nonylphenol.
Mesoporous bata-tricalcium phosphate raw powder's production technology the most according to claim 1, it is characterised in that: step 2) described in the mixing that calcic inorganic salt is any one or more in four water-calcium nitrate, calcium chloride, calcium carbonate, calcium sulfate, calcium chlorate.
Mesoporous bata-tricalcium phosphate raw powder's production technology the most according to claim 1, it is characterised in that: step 2) described in the mixing that inorganic phosphor-contained salt is any one or more in diammonium phosphate, sodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, Polymeric sodium metaphosphate., sodium hexameta phosphate, ammonium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium dihydrogen phosphate.
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