CN104435310B - 一种治疗脑梗塞、脑出血后遗症的药物及制备方法 - Google Patents

一种治疗脑梗塞、脑出血后遗症的药物及制备方法 Download PDF

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CN104435310B
CN104435310B CN201410627486.1A CN201410627486A CN104435310B CN 104435310 B CN104435310 B CN 104435310B CN 201410627486 A CN201410627486 A CN 201410627486A CN 104435310 B CN104435310 B CN 104435310B
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文怡海
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Abstract

本发明属于中药技术领域,公开了一种治疗脑梗塞、脑出血后遗症的药物及制备方法。所述药物由以下重量份的原料药制备而成:川芎10~20份,生地10~20份,桃仁5~10份,赤芍5~10份,全蝎5~10份,僵蚕5~10份,蜈蚣5~10份。通过将各原料药粉碎混合或将原料药混合后用水浸泡煎煮,再浓缩干燥、粉碎混合,得到本发明的一种治疗脑梗塞、脑出血后遗症的药物。本发明药物治疗效果显著、携带与服用方便,成本低廉。

Description

一种治疗脑梗塞、脑出血后遗症的药物及制备方法
技术领域
本发明属于中药技术领域,具体涉及一种治疗脑梗塞、脑出血后遗症的药物及制备方法。
背景技术
脑梗塞后遗症是临床医生治疗起来比较棘手的一类神经性疾病,由于脑梗塞、脑出血后遗症危害性大,易出现诱发并发症,对人们的身体健康造成了极大的危害,而现有的治疗脑梗塞、脑出血后遗症的药物疗效不稳定,费用较高,因此有效治疗脑梗塞、脑出血后遗症仍然是医学研究攻关的一个重要课题。
通过中药复方治疗脑梗塞、脑出血后遗症是一个重要的方向,中药治疗脑梗塞、脑出血后遗症的药物大部分来自民间组方。如在中国专利201310323620.4中,即公开了一种治疗脑梗塞的药物,其组分包括槐角、金丝刷、神曲、紫草茸、火焰兰、青蒿、葱须、艾纳香、皂荚、六月雪、草乌头、石防风、金沸草、侧柏叶、磁石和胆星;中国专利201210136357.3中,公开了一种治疗脑出血、脑梗塞疾病和其后遗症的中药,其组分包括水蛭、鸡血藤、地龙、三七参、黄芪、防风、川牛夕、桂枝、制马前子、龙胆、赤芍、水牛角、白花蛇、羌活、木瓜、蜈蚣;中国专利200810064206.5公开了一种治疗脑出血后遗症、脑梗塞及脑血栓的中药,其组分包括羚羊角、全虫、钩藤、僵蚕、白附子、桂枝、防风、乳香、麻黄、天麻、麝香和当归。由此可见,民间用于治疗脑梗塞、脑出血后遗症的中药复方总类繁多,原料来源及治疗效果也各有差异。
发明内容
针对以上现有技术的不足之处,本发明的首要目的在于提供一种脑梗塞、脑出血后遗症的药物。
本发明的另一目的在于提供上述药物的制备方法。
本发明目的通过以下技术方案实现:
一种治疗脑梗塞、脑出血后遗症的药物,由以下重量份的原料药制备而成:川芎10~20份,生地10~20份,桃仁5~10份,赤芍5~10份,全蝎5~10份,僵蚕5~10份,蜈蚣5~10份。
上述原料药的重量份优选为:川芎20份,生地20份,桃仁10份,赤芍10份,全蝎10份,僵蚕10份,蜈蚣7份。
上述原料药还包括以下重量份的组分:天麻18份,防风12份,秦艽12份,归尾10份。
上述治疗脑梗塞、脑出血后遗症药物的制备方法:按重量份称取上述原料药,然后将其分别粉碎成50~100目,再将粉碎后的各原料药混合均匀即得。
上述治疗脑梗塞、脑出血后遗症药物的另一种制备方法:按重量份称取上述原料药混合均匀,然后加入原料药总重量8~12倍50~90℃的热水浸泡1~2小时,再加热至沸腾后煎煮1.5~2.5小时,过滤,取滤液干燥得干燥粉,将干燥粉粉碎成50~100目即得。
通过上述方法制备得到的治疗脑梗塞、脑出血后遗症的药物还可以加入制剂成型所需的辅料,按照药物制剂常规方法做成临床上适宜的各种制剂;所述的制剂包括胶囊剂、丸剂、颗粒剂、片剂或口服液。
本发明原料药中,川芎具有活血行气,祛风止痛自功效,适宜瘀血阻滞各种病症;生地具有清热凉血、益阴生津之功效,可用于治疗血热毒盛,吐血衄血;桃仁具有有活血祛瘀的功效,适用于症瘕结块,肺痈肠痈,跌仆伤痛等症状;赤芍具有行瘀、止痛、凉血、消肿之功效;全蝎具有熄风镇痉、消炎攻毒、通络止痛之功效;僵蚕具有熄风止痉、祛风止痛、化痰散结之功效,适用于惊风抽搐,面神经麻痹;蜈蚣具有息风解痉之功效。
本发明的原料药的配伍特点:以川芎、生地、桃仁、赤芍组合,用以解脑梗塞、脑出血引发的淤血阻滞、消肿止痛;配合全蝎、僵蚕和蜈蚣,用以解脑梗塞、脑出血引发的神经损伤及神经炎症,双管齐下,达到完全治愈脑梗塞、脑出血后遗症的目的。另外本方中还可添加天麻、防风、秦艽和归尾作为辅药,治疗效果更佳。
本发明的制备方法及所得到的药物具有如下优点及有益效果:
(1)本发明的药物解痉消肿祛风,对脑梗塞、脑出血后遗症具有独特疗效;
(2)本发明的药物丰富了我国用于治疗脑梗塞、脑出血后遗症中药复方的种类,开拓了该类中药复方中原料药的来源,避免了对中药资源的集中掠夺;
(3)本发明的药物成本低廉,携带与服用方便。
具体实施方式
下面结合实施例对本发明作进一步详细的描述,但本发明的实施方式不限于此。
实施例1
称取川芎2kg,生地2kg,桃仁1kg,赤芍1kg,全蝎1kg,僵蚕1kg,蜈蚣0.7kg,天麻1.8kg,防风1.2kg,秦艽1.2kg,归尾1kg,分别粉碎至50~100目,再将粉碎后的原料药混合均匀得到药粉,按每粒胶囊含0.3g上述药粉进行制备分装,得到一种治疗脑梗塞、脑出血后遗症的胶囊。
实施例2
称取川芎2kg,生地2kg,桃仁1kg,赤芍1kg,全蝎1kg,僵蚕1kg,蜈蚣0.7kg,天麻1.8kg,防风1.2kg,秦艽1.2kg,归尾1kg混合均匀,加入上述原料药总质量10倍的70℃的热水浸泡1.5h,然后加热至沸腾煎煮2小时,过滤,取滤液浓缩至相对密度为1.1~1.2,然后喷雾干燥得干燥粉,将干燥粉粉碎成100目,得到一种治疗脑梗塞、脑出血后遗症的药物。
实施例3
称取川芎2kg,生地2kg,桃仁1kg,赤芍1kg,全蝎1kg,僵蚕1kg,蜈蚣0.7kg混合均匀,加入上述原料药总质量10倍的70℃的热水浸泡1.5h,然后加热至沸腾煎煮2小时,过滤,取滤液浓缩至相对密度为1.1~1.2,然后喷雾干燥得干燥粉,将干燥粉粉碎成100目,得到一种治疗脑梗塞、脑出血后遗症的药物。
实施例4
称取川芎1kg,生地1kg,桃仁0.5kg,赤芍0.5kg,全蝎0.5kg,僵蚕0.5kg,蜈蚣0.5kg,分别粉碎至50~100目,再将粉碎后的原料药混合均匀得到药粉,按每粒胶囊含0.3g上述药粉进行制备分装,得到一种治疗脑梗塞、脑出血后遗症的胶囊。
实施例1得到的一种治疗脑梗塞、脑出血后遗症的胶囊用于脑梗塞、脑出血后遗症的临床治疗:患者口服。每日3次,每次4粒胶囊,一个疗程为30天。以下为部分临床治疗结果:
1、邓某,女,52岁,头晕、头痛、乏力、失眠,CT报告显示脑积液,经当地医院治疗2年,各症状未减,诊断为脑梗塞后遗症,经来我门诊治疗,服用本发明药物两个月,上述症状完全消失,经CT检查脑积液等各项指标正常;
2、张某,女,53岁,因脑出血术后出血头晕,头痛,左侧上下肢活动受限,言语不清,经CT检查,提示严重脑出血后遗症,经来我门诊治疗,服用本发明药物两个月,上述症状明显好转,CT检查脑水肿已消失;
3、邓某,男,58岁,因左侧瘫痪,言语不清,活动困难,CT检查为脑梗塞后遗症,经来我门诊治疗,服用本发明药物两个月,上述症状明显改善,CT检查脑水肿已消失;
4、文某,男,35岁,因头晕、头痛、乏力、失眠一月余,经CT检查为脑水肿,自来我门诊治疗,服用本发明药物一个月,上述症状完全消失吗,经CT检查无脑积液,各项指标正常。
本发明的药物经十多年临床使用,治疗脑梗塞、脑出血后遗症无毒副作用,疗效好。经治疗的47例脑梗塞、脑出血后遗症,治疗有效率为98%,治愈率达到90%以上。
上述实施例为本发明较佳的实施方式,但本发明的实施方式并不受上述实施例的限制,其它的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化,均应为等效的置换方式,都包含在本发明的保护范围之内。

Claims (7)

1.一种治疗脑梗塞、脑出血后遗症的药物,其特征在于:所述药物由以下重量份的原料药制备而成:川芎10~20份,生地10~20份,桃仁5~10份,赤芍5~10份,全蝎5~10份,僵蚕5~10份,蜈蚣5~10份。
2.根据权利要求1所述的一种治疗脑梗塞、脑出血后遗症的药物,其特征在于:所述原料药的重量份为:川芎20份,生地20份,桃仁10份,赤芍10份,全蝎10份,僵蚕10份,蜈蚣7份。
3.一种治疗脑梗塞、脑出血后遗症的药物,其特征在于:所述药物由以下重量份的原料药制备而成:川芎20份,生地20份,桃仁10份,赤芍10份,全蝎10份,僵蚕10份,蜈蚣7份,天麻18份,防风12份,秦艽12份,归尾10份。
4.权利要求1~3任一项所述的一种治疗脑梗塞、脑出血后遗症药物的制备方法,其特征在于:按重量份称取原料药,然后将其分别粉碎成50~100目,再将粉碎后的各原料药混合均匀,得到所述治疗脑梗塞、脑出血后遗症的药物。
5.权利要求1~3任一项所述的一种治疗脑梗塞、脑出血后遗症药物的制备方法,其特征在于:按重量份称取原料药混合均匀,然后加入原料药总重量8~12倍50~90℃的热水浸泡1~2小时,再加热至沸腾后煎煮1.5~2.5小时,过滤,取滤液干燥得干燥粉,将干燥粉粉碎成50~100目,得到所述治疗脑梗塞、脑出血后遗症的药物。
6.一种治疗脑梗塞、脑出血后遗症的药物制剂,其特征在于:通过权利要求1~3任一项所述的药物加入制剂成型所需的辅料制备得到。
7.根据权利要求6所述的一种治疗脑梗塞、脑出血后遗症的药物制剂,其特征在于:所述的制剂包括胶囊剂、丸剂、颗粒剂、片剂或口服液。
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