CN104435268A - Traditional Chinese medicine composition for treating acute nephritis as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating acute nephritis as well as preparation method and application thereof Download PDFInfo
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- CN104435268A CN104435268A CN201410295148.2A CN201410295148A CN104435268A CN 104435268 A CN104435268 A CN 104435268A CN 201410295148 A CN201410295148 A CN 201410295148A CN 104435268 A CN104435268 A CN 104435268A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/756—Phellodendron, e.g. corktree
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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Abstract
The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following crude drugs in parts by weight: 15-25 parts of crotalaria albida, 20-30 parts of sungrass, 10-20 parts of cortex phellodendri, 6-10 parts of rhizoma atractylodis, 10-20 parts of polygonum aviculare, 18-22 parts of grifola, 10-15 parts of rhizoma alismatis and 15-25 parts of glossy privet fruit. The traditional Chinese medicine composition is capable of reducing fever and causing dieresis, diminishing inflammation and eliminating dampness, and treating acute nephritis. The invention also discloses a preparation method and use of the traditional Chinese medicine composition.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that are used for the treatment of acute nephritis.
Background technology
Acute glomerulonephritis is the acute renal glomerulus illness caused by Different types of etiopathogenises, is much wherein because of antibacterial, virus, protozoan infection and bringing out.The brightic morbidity of pregnancy associated with acute caused by the immunoreation caused after streptococcal infection, belongs to a kind of Immune complexes nephritis mostly.Patient is weak, and headache, nauseating and vomiting, can merge acute lung edema, acute renal failure or hypertensive encephalopathy further.Lack real effective patent medicine in the market.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that are used for the treatment of acute nephritis.
Technical scheme: the object of the invention is by following scheme realize:
Treat a Chinese medicine composition for acute nephritis, it is extracted by the crude drug of following parts by weight and prepares: jingle bell bean 15-25 part, Herba Polygoni Capitati 20-30 part, Cortex Phellodendri 10-20 part, Rhizoma Atractylodis 6-10 Fen, Herba Polygoni Avicularis 10-20 part, Polyporus 18-22 part, Rhizoma Alismatis 10-15 part, Fructus Ligustri Lucidi 15-25 part.
The Chinese medicine composition of described treatment acute nephritis, it is extracted by the crude drug of following parts by weight and prepares: jingle bell bean 20 parts, Herba Polygoni Capitati 25 parts, Cortex Phellodendri 15 parts, Rhizoma Atractylodis 8 Fen, Herba Polygoni Avicularis 15 parts, Polyporus 20 parts, Rhizoma Alismatis 12 parts, Fructus Ligustri Lucidi 20 parts.
The Chinese medicine composition of described treatment acute nephritis, preparation method comprises the steps: to get jingle bell bean, Herba Polygoni Capitati, Cortex Phellodendri, Rhizoma Atractylodis, Herba Polygoni Avicularis, Polyporus, Rhizoma Alismatis, Fructus Ligustri Lucidi merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
The application of Chinese medicine composition in preparation treatment acute nephritis medicine of described treatment acute nephritis.
Raw jingle bell bean of the present invention is pulse family Crotalaria plant jingle bell bean Crotalaria albida Heyne, with root and all herbal medicine.Herba Polygoni Capitati is the herb of polygonaceae plant Herba Polygoni Capitati, latin name: Polygonum capitatumBuch.-Ham.exD.Don.All the other are pharmacopeia kind.
Beneficial effect:
From theory of Chinese medical science, in we, jingle bell bean, Herba Polygoni Capitati regulating QI to relieve pain clearing away heat and promoting diuresis are monarch drug, Cortex Phellodendri, Rhizoma Atractylodis, Herba Polygoni Avicularis, Polyporus, Rhizoma Alismatis diuretic dampness, be ministerial drug altogether, Fructus Ligustri Lucidi invigorating the liver and kidney is adjuvant, all medicines are harmonious, and play clearing away heat and promoting diuresis, the effect of antiinflammatory dampness altogether, are used for the treatment of acute nephritis.Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, and determined curative effect.Consist of Chinese crude drug, have no side effect, low price.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
One, preparation embodiment 1: get jingle bell bean 20g, Herba Polygoni Capitati 25g, Cortex Phellodendri 15g, Rhizoma Atractylodis 8g, Herba Polygoni Avicularis 15g, Polyporus 20g, Rhizoma Alismatis 12g, Fructus Ligustri Lucidi 20g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch and make capsule.
Preparation embodiment 2: get jingle bell bean 15g, Herba Polygoni Capitati 30g, Cortex Phellodendri 10g, Rhizoma Atractylodis 10g, Herba Polygoni Avicularis 10g, Polyporus 22g, Rhizoma Alismatis 10g, Fructus Ligustri Lucidi 15g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch, pelletizing press sheet makes tablet.
Preparation embodiment 3: get jingle bell bean 25g, Herba Polygoni Capitati 20g, Cortex Phellodendri 20g, Rhizoma Atractylodis 6g, Herba Polygoni Avicularis 20g, Polyporus 18g, Rhizoma Alismatis 15g, Fructus Ligustri Lucidi 25g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch, granule is made in granulation.
Two, the present invention is to the clinical trial data of acute nephritis
The physical data of experimental subject: adopt the present invention to treat 30 examples altogether, the oldest person 32 years old, age reckling 17 years old, male 16 example, women 14 example.
Diagnostic criteria:
(1) clinical manifestation
1) systemic infection symptom: the shiver with cold occurred suddenly, high heat, body temperature reaches more than 39 DEG C, with headache, Nausea and vomiting and inappetence etc.
2) local symptom: lumbago and hypogastric region pain can be one-sided or bilateral, have obvious kidney district tenderness and kowtow pain, can have costispinal angle and ureter point tenderness.
3) irritation sign of bladder: the irritations sign of bladder such as frequent micturition, urgent micturition, dysurea.During ascending infection, irritation sign of bladder occurs prior to General Symptoms, and hematogenous infection is often by heating.
(2) lab testing:: 1. numeration of leukocyte raises, and can reach 20 × more than 10^9L, and neutral more than 90%.2. the visible cloudy urine of routine urianlysis, can have pyuria, bacteriuria, moderate albuminuria, under common mirror or gross hematuria.Visible white cell cast and iridocyte once in a while, Quantitative urine culture >=105/ml.
(3) B-mode ultrasonography: ultrasonic examination is abnormal without other except can finding Kidney Volume and increasing.Compare with offside kidney, find Ipsilateral kidney Echo heterogenicity sometimes.But when disease is further development of microabscess formation, then this performance is more obvious.
(4) CT scan: CT examination is usually also without exception.CT enhanced ct scans is better to kidney parenchymal bluss, can show inflammation preferably and change.Be usually expressed as Kidney Volume to increase, organize enhancing to weaken by infringement, show as disorganization and obvious anisotropy in serious case.
(5) ureteral catheterization that the level diagnosis infected: Stamey describes and the separable pathogenic bacterium to upper urinary tract infection of the bladder washout method that Fairley describes, but usually only for experiment, be rarely used in clinical.Other methods and results is many not certainly or without specificity.
Therapeutic Method: usage and dosage: adopt the capsule prepared by the embodiment of the present invention 1, its usage and consumption are each 8, and every day 3 times, warm water takes, and one week are a course for the treatment of, treat for 4 courses for the treatment of altogether.
The standard of curative effect evaluation:
Cure: clinical manifestation transference cure, sign is improved completely, happy, in high spirits.
Effective: clinical manifestation transference cure, sign makes moderate progress, and mood and spirit are better.
Invalid: clinical manifestation symptom does not disappear, sign and symptom are improved not obvious or without improvement.
Experimental result: in accept for medical treatment 30 routine cases, through treatment in 1 month, wherein cures 10 examples, effective 16 examples, and invalid 4 examples, total effective rate reaches 86.7%.Show that the present invention has extremely significant effect to treatment acute nephritis patient.
Claims (4)
1. treat the Chinese medicine composition of acute nephritis for one kind, it is characterized in that, it is extracted by the crude drug of following parts by weight and prepares: jingle bell bean 15-25 part, Herba Polygoni Capitati 20-30 part, Cortex Phellodendri 10-20 part, Rhizoma Atractylodis 6-10 Fen, Herba Polygoni Avicularis 10-20 part, Polyporus 18-22 part, Rhizoma Alismatis 10-15 part, Fructus Ligustri Lucidi 15-25 part.
2. treat the Chinese medicine composition of acute nephritis as claimed in claim 1, it is characterized in that, it is extracted by the crude drug of following parts by weight and prepares: jingle bell bean 20 parts, Herba Polygoni Capitati 25 parts, Cortex Phellodendri 15 parts, Rhizoma Atractylodis 8 Fen, Herba Polygoni Avicularis 15 parts, Polyporus 20 parts, Rhizoma Alismatis 12 parts, Fructus Ligustri Lucidi 20 parts.
3. treat the Chinese medicine composition of acute nephritis as claimed in claim 1, it is characterized in that, preparation method comprises the steps: to get jingle bell bean, Herba Polygoni Capitati, Cortex Phellodendri, Rhizoma Atractylodis, Herba Polygoni Avicularis, Polyporus, Rhizoma Alismatis, Fructus Ligustri Lucidi merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
4. described in claim 1, treat the application of Chinese medicine composition in treatment acute nephritis medicine of acute nephritis.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1683001A (en) * | 2005-03-14 | 2005-10-19 | 庹元斌 | Chinese medicine for treating gout |
| KR20140046565A (en) * | 2012-10-05 | 2014-04-21 | 한국과학기술연구원 | Composition for preventing or treating renal disease containing extract of amorpha fruticosa |
-
2014
- 2014-06-26 CN CN201410295148.2A patent/CN104435268A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1683001A (en) * | 2005-03-14 | 2005-10-19 | 庹元斌 | Chinese medicine for treating gout |
| KR20140046565A (en) * | 2012-10-05 | 2014-04-21 | 한국과학기술연구원 | Composition for preventing or treating renal disease containing extract of amorpha fruticosa |
Non-Patent Citations (1)
| Title |
|---|
| 施杞等: "《现代中医药应用与研究大系 第八卷 儿科》", 31 December 1995, 上海中医药大学出版社 * |
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