CN104434893A - Diclofenac sodium lidocaine hydrochloride freeze-dried powder injection for injection and preparation method of freeze-dried powder injection - Google Patents
Diclofenac sodium lidocaine hydrochloride freeze-dried powder injection for injection and preparation method of freeze-dried powder injection Download PDFInfo
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Abstract
The invention relates to the technical field of medicinal preparations and in particular discloses a diclofenac sodium lidocaine hydrochloride freeze-dried powder injection for injection and a preparation method of the freeze-dried powder injection. The freeze-dried powder injection comprises diclofenac sodium, lidocaine hydrochloride, a co-solvent, a pH regulation agent, an antioxidant, a metal complexing agent, and injection water as a solvent, wherein polyethylene glycol 4000 is used as the co-solvent; the co-solvent also has the effect of a freeze-dried product skeleton agent; the pH regulation agent comprises sodium carbonate and hydrochloric acid; the antioxidant is sodium sulfite; the metal complexing agent is edetate disodium; the solvent is injection water. With the improvement of the formula and the combination of the improvement of the preparation process, the prepared freeze-dried powder injection is high in stability and redissolubility; the freeze-dried powder injection can be diluted by a small amount of injection water and then injected intramuscularly; the medicine administration risk is reduced; since the auxiliary materials such as tween-80, propylene glycol and the like are not used, the side effect of the medicine can be reduced; the safety of the medicine is improved; the freeze-dried powder injection has a good application prospect.
Description
Technical field
The present invention relates to technical field of medicine, be specifically related to a kind of injection diclofenac sodium lidocaine hydrochloride freeze-dried powder and preparation method thereof.
Background technology
Diclofenac sodium (diclofenac sodium is called for short DS), is non_steroidal anti_inflammatory drug, effectively can alleviates the symptom with inflammation-related.It has been generally acknowledge both at home and abroad that its oral application is worth, but its gastrointestinal side effect limits its clinical practice.Diclofenac Sodium Injection can avoid direct stimulating gastrointestinal road.
The stronger pain in Diclofenac Sodium Injection intramuscular injection local.If with the addition of lignocaine, can effectively reduce injection point pain, reduce injection site tissue damage.And, lignocaine onset speed is fast, action intensity is high, but action effective shorter (<2 hour), diclofenac sodium onset speed is slow, but action effective is long, action intensity is high, and the combination of (antiinflammatory) analgesic of two kinds of pharmacokinetics complementations makes its curative effect more perfect, after drug administration by injection, first lidocaine hydrochloride onset in 5 minutes, the pain symptom of rapid reduction of patient, diclofenac sodium onset subsequently, plays its potent anti-inflammatory analgesic action, reach 12 ~ 24 hours action time, the state of an illness of patient can be controlled better.What Mepha company of Switzerland produced has entered people's Chinese market for intramuscular injection compound diclofenac sodium injection, and its commodity are called Ao Erfen (Olferi), and specification is 2mL, wherein containing principal agent diclofenac sodium 75.0mg, lidocaine hydrochloride 20.0mg.
Diclofenac sodium is slightly molten in water, pH value about 6.5 ~ 7.5, and in acid condition, diclofenac sodium solution isolates diclofenac; Lidocaine hydrochloride is soluble in water, pH value about 3.5 ~ 5.5, when two kinds of compatibility of drugss make injection, easily occurs the problem of diclofenac sodium crystallization in aqueous.
Xie Jun, Zhou Jianping, Huang Chunyu adopt add more than 40% PEG400 and the mixed solvent of propylene glycol (3:1) to dissolve diclofenac sodium.Similar, disclose a kind of technology of preparing of diclofenac potassium lidocaine hydrochloride injection in patent CN1557290A, same employing PEG400 and mixed with propylene glycol dissolution with solvents diclofenac potassium.
All in large quantities with an organic solvent, prepared medicine, to the zest of patient and side effect comparatively large (such as pain, injection site inflammation, allergy etc.), has had a strong impact on the Clinical practice of medicine to above technology.
Patent CN1279897C provides a kind of 2% ~ 10% tween 80 that adopts as cosolvent, dissolves diclofenac sodium contains diclofenac salt and lignocaine lyophilized formulations with preparation; But tween 80 has potential haemolysis, a large amount of tween 80 that uses is as cosolvent, and Clinical practice exists potential safety hazard, meanwhile, because tween 80 is a kind of liquid of thickness, a large amount of uses add the difficulty of medicine lyophilizing, be unfavorable for shortening lyophilization cycle, save production cost.
The Polyethylene Glycol (Macrogol 200 ~ 600) that molecular weight is lower is more as the application and research of solvent and cosolvent, but the Polyethylene Glycol of high molecular seldom has research report as cosolvent, also has no the example of application.Applicant, through research, finds using Macrogol 4000 as cosolvent, effectively can increase the dissolubility of diclofenac sodium in water.Especially, because Macrogol 4000 fusing point is at about 55 DEG C, is solid under room temperature, therefore in lyophilized formulations, also can be used as framework material, effectively can improve outward appearance and the physical stability of freeze-dried products, increase the stability of freeze-dried products.
The present invention intends adopting Macrogol 4000 as cosolvent and skeleton agent, utilize sodium carbonate, hydrochloric acid as acid-base modifier, sodium sulfite is as antioxidant, disodium edetate is as metal chelating agent, coordinate special preparation technology, the injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of preparation, effectively can solve the deficiency of composition and engineering in prior art, the sample of preparation has good solubility, stability, low irritant.Ensure that safety and the compliance of this types of drugs clinical application, there is higher practical value.
Summary of the invention
For the deficiencies in the prior art, the object of the invention is to: 1, a kind of injection diclofenac sodium lidocaine hydrochloride freeze-dried powder is provided; 2, a kind of preparation method of described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder is provided.
The injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of gained of the present invention, has good solubility, stability, low irritant.Ensure that safety and the compliance of this types of drugs clinical application.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is made up of diclofenac sodium, lidocaine hydrochloride, Macrogol 4000, disodium edetate, anhydrous sodium sulfite, qs pH adjuster.
Described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, its each ingredients weight parts proportioning is as follows:
Described pH adjusting agent is sodium carbonate and/or hydrochloric acid.
Wherein, qs pH adjuster is in order to regulate the pH of described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder final solution in preparation process 8.5 ~ 9.5.
Optimum, described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, its each ingredients weight parts proportioning is as follows:
Described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by the raw material of following weight:
Described pH adjusting agent is sodium carbonate and/or hydrochloric acid, and described sodium carbonate, hydrochloric acid respectively preferred concentration are the aqueous solution of 10wt%, 0.1M, and in pH adjusting agent, the amount of water is not counted in the consumption of feed injection water.
Wherein, water for injection is described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder solvent used in preparation process, and water for injection is removed in follow-up preparation process.
Wherein, qs pH adjuster is in order to regulate the pH of described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder final solution in preparation process 8.5 ~ 9.5.
Optimum, described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by the raw material of following weight:
A preparation method for the injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of above-mentioned each formula, its step is as follows:
(1) precision takes various raw material, adjuvant, for subsequent use.
(2) in Agitation Tank, add the water for injection of 65% of about formula ratio and be cooled to 40 DEG C ~ 60 DEG C, add the Macrogol 4000 of formula ratio, diclofenac sodium puts in Agitation Tank, stirring makes it dissolve completely, be 11.0-12.0 with the sodium carbonate liquor of 10wt% and/or 0.1M hydrochloric acid adjust pH, obtain medicinal liquid A.
(3) water for injection of 20% of formula ratio is cooled to 20 DEG C ~ 28 DEG C, the lidocaine hydrochloride adding formula ratio stirs and makes it dissolve, then adds anhydrous sodium sulfite and disodium edetate and stir and make it dissolve completely, obtains medical liquid B.
(4) medical liquid B is slowly added in medicinal liquid A, stir, mixing.Between the sodium carbonate liquor under agitation slowly using 10wt% and/or 0.1M hydrochloric acid adjust pH to 8.5 ~ 9.5, add residue water for injection.
(5) needle-use activated carbon is added by 0.03% (w/w), mixing; Circulating filtration 30 minutes while stirring, via hole diameter is 0.45 μm, 0.22 μm micropore filter element filtering decarbonization successively, sampling, is transported in surge tank again after inspection intermediates content is qualified through bottling department 0.22 μm of micropore filter element fine straining, stand-by.
(6) fill: calculate loading amount according to intermediates content, fill is in injection bottles made of glass tubes.
(7) lyophilization, roll and cover to obtain finished product.
The freeze-dried powder that the present invention obtains is white or micro-yellowy lyophilized powder or lyophilizing block.Pharmaceutical properties is stablized, and through high temperature, illumination experiment, its content, related substance, pH value, solubility etc. obviously do not change substantially.Muscle irritation result of study shows, this injection muscle irritation is less than drugs compared.
Compared with prior art, advantage of the present invention and beneficial effect are:
1. injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of the present invention is not containing organic solvents such as ethanol, propylene glycol, PEG400s, and also not containing surfactants such as tween 80s, safety and stability, muscle irritation is little.
2. when prepared by injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of the present invention, lyophilization cycle is short, is conducive to shortening the production cycle, energy efficient, reduces production cost.
3. injection diclofenac sodium lidocaine hydrochloride freeze-dried powder solubility of the present invention is good, during clinical application, the water for injection just energy dissolved substance of about 1ml, make intramuscular injection volumes little, advantageously in the reduction zest of medicine and the malaise symptoms such as pain, stimulation, burning sensation of agents area.
4. injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of the present invention shows through results of stability, its good stability, is convenient to storage and transport.
Detailed description of the invention
Following each embodiment is used for further illustrating the present invention, but does not limit the scope of claims of the present invention request protection.
In following each embodiment, raw materials used diclofenac sodium, lidocaine hydrochloride, Macrogol 4000, disodium edetate, anhydrous sodium sulfite, water for injection, 10wt% sodium carbonate, 0.1M hydrochloric acid are pharmaceutical injection level.
Embodiment 1:
A kind of injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by diclofenac sodium, lidocaine hydrochloride, Macrogol 4000, disodium edetate, anhydrous sodium sulfite, water for injection, sodium carbonate, hydrochloric acid;
Described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by the raw material of following weight:
The preparation method of the injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of above-mentioned raw materials formula, its step is as follows:
(1) precision takes various raw material, adjuvant, for subsequent use.
(2) in Agitation Tank, add the water for injection of 65% of about formula ratio and be cooled to 40-42 DEG C, add the Macrogol 4000 of formula ratio, diclofenac sodium puts in Agitation Tank, stirring makes it dissolve completely, with 10wt% sodium carbonate and 0.1M hydrochloric acid adjust pH to 11.3, obtains medicinal liquid A.
(3) water for injection of 20% of formula ratio is cooled to 26-28 DEG C, the lidocaine hydrochloride adding formula ratio stirs and makes it dissolve, then adds anhydrous sodium sulfite and disodium edetate and stir and make it dissolve completely, obtains medical liquid B.
(4) medical liquid B is slowly added in medicinal liquid A, stir, mixing.Under agitation slowly use sodium carbonate and the 0.1M hydrochloric acid adjust pH to 8.7 of 10wt%, add residue water for injection.
(5) needle-use activated carbon is added by 0.03% (w/w), mixing.Circulating filtration 30 minutes while stirring, via hole diameter is the micropore filter element filtering decarbonization of 0.45 μm, 0.22 μm successively, sampling, is transported in surge tank again after inspection intermediates content is qualified through bottling department 0.22 μm of micropore filter element fine straining, stand-by.
(6) fill: calculate loading amount according to intermediates content, fill is in injection bottles made of glass tubes.
(7) lyophilization: pre-freezing temperature is-45 DEG C, sample is incubated 3 hours, after pre-freeze is terminated, and opens vacuum, makes vacuum at about 15pa, slowly products temperature is risen to-10 DEG C, be incubated 2 hours; Insulation terminates, and slowly temperature is risen to 25 DEG C, be incubated 2 hours, lyophilizing terminates.Have suffered freeze-drying time and be about 20 hours.
(8) roll and cover to obtain finished product.
The finished product that the present embodiment obtains is the lyophilizing block of white.
Embodiment 2:
A kind of injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by diclofenac sodium, lidocaine hydrochloride, Macrogol 4000, disodium edetate, anhydrous sodium sulfite, water for injection, sodium carbonate, hydrochloric acid;
Described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by the raw material of following weight:
The preparation method of the injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of above-mentioned raw materials formula, its step is as follows:
(1) precision takes various raw material, adjuvant, for subsequent use.
(2) in Agitation Tank, add the water for injection of 65% of about formula ratio and be cooled to 50-52 DEG C, add the Macrogol 4000 of formula ratio, diclofenac sodium puts in Agitation Tank, stirring makes it dissolve completely, with 10wt% sodium carbonate and 0.1M hydrochloric acid adjust pH 11.5, obtains medicinal liquid A.
(3) water for injection of 20% of formula ratio is cooled to 20-22 DEG C, the lidocaine hydrochloride adding formula ratio stirs and makes it dissolve, then adds anhydrous sodium sulfite and disodium edetate and stir and make it dissolve completely, obtains medical liquid B.
(4) medical liquid B is slowly added in medicinal liquid A, stir, mixing.Under agitation slowly use sodium carbonate and the 0.1M hydrochloric acid adjust pH to 9.1 of 10wt%, add residue water for injection.
(5) needle-use activated carbon is added by 0.03% (w/w), mixing.Circulating filtration 30 minutes while stirring, via hole diameter is the micropore filter element filtering decarbonization of 0.45 μm, 0.22 μm successively, sampling, is transported in surge tank again after inspection intermediates content is qualified through bottling department 0.22 μm of micropore filter element fine straining, stand-by.
(6) fill: calculate loading amount according to intermediates content, fill is in injection bottles made of glass tubes.
(7) lyophilization: pre-freezing temperature is-45 DEG C, sample is incubated 3 hours, after pre-freeze is terminated, and opens vacuum, makes vacuum at about 15pa, slowly products temperature is risen to-10 DEG C, be incubated 2 hours; Insulation terminates, and slowly temperature is risen to 25 DEG C, be incubated 2 hours, lyophilizing terminates.Have suffered freeze-drying time and be about 20 hours.
(8) roll and cover to obtain finished product.
The finished product that the present embodiment obtains is the lyophilizing block of white.
Embodiment 3:
A kind of injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by diclofenac sodium, lidocaine hydrochloride, Macrogol 4000, disodium edetate, anhydrous sodium sulfite, water for injection, sodium carbonate, hydrochloric acid;
Described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by the raw material of following weight:
The preparation method of the injection diclofenac sodium lidocaine hydrochloride freeze-dried powder of above-mentioned raw materials formula, its step is as follows:
(1) precision takes various raw material, adjuvant, for subsequent use.
(2) in Agitation Tank, add the water for injection of 65% of about formula ratio and be cooled to 58-60 DEG C, add the Macrogol 4000 of formula ratio, diclofenac sodium puts in Agitation Tank, stirring makes it dissolve completely, with 10wt% sodium carbonate and 0.1M hydrochloric acid adjust pH 11.8, obtains medicinal liquid A.
(3) water for injection of 20% of formula ratio is cooled to 22-24 DEG C, the lidocaine hydrochloride adding formula ratio stirs and makes it dissolve, then adds anhydrous sodium sulfite and disodium edetate and stir and make it dissolve completely, obtains medical liquid B.
(4) medical liquid B is slowly added in medicinal liquid A, stir, mixing.Under agitation slowly use sodium carbonate and the 0.1M hydrochloric acid adjust pH to 9.4 of 10wt%, add residue water for injection.
(5) needle-use activated carbon is added by 0.03% (w/w), mixing.Circulating filtration 30 minutes while stirring, via hole diameter is the micropore filter element filtering decarbonization of 0.45 μm, 0.22 μm successively, sampling, is transported in surge tank again after inspection intermediates content is qualified through bottling department 0.22 μm of micropore filter element fine straining, stand-by.
(6) fill: calculate loading amount according to intermediates content, fill is in injection bottles made of glass tubes.
(7) lyophilization: pre-freezing temperature is-45 DEG C, sample is incubated 3 hours, after pre-freeze is terminated, and opens vacuum, makes vacuum at about 15pa, slowly products temperature is risen to-10 DEG C, be incubated 2 hours; Insulation terminates, and slowly temperature is risen to 25 DEG C, be incubated 2 hours, lyophilizing terminates.Have suffered freeze-drying time and be about 20 hours.
(8) roll and cover to obtain finished product.
The finished product that the present embodiment obtains is the lyophilizing block of white.
Injection diclofenac sodium lidocaine hydrochloride freeze-dried powder obtained to above-described embodiment 1,2,3 has respectively carried out the stability study of high temperature (60 DEG C), high light (4500Lx), and experimental result is as follows:
Experimental result shows, the present invention produce injection diclofenac sodium lidocaine hydrochloride freeze-dried powder to high light and high temperature all more stable.
The injection diclofenac sodium lidocaine hydrochloride freeze-dried powder obtained to embodiment 1-3 and commercially available compound diclofenac sodium and lidocaine hydrochloride injection have carried out muscle irritation comparative experimental research (test method: Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline, in March, 200 5), result of study shows:
The freeze-dried powder that embodiment of the present invention 1-3 is obtained, give rabbit drug administration by injection continuous three times respectively, 4 points are to rabbit quadriceps femoris four pieces of muscle total scores, and after the administration of commercially available Comparative formulation single injection, be 8 points to rabbit quadriceps femoris four pieces of muscle total scores, illustrate that the zest of freeze-dried powder prepared by the present invention is less than Comparative formulation.
The lyophilized injectable powder obtained to embodiment 1-3 is respectively got 5 (specification is: often prop up containing diclofenac sodium 75mg, lidocaine hydrochloride 20mg (in lignocaine)) and is carried out solubility experiment, solubility test solvent is water for injection, the volume of test solvent is 1ml, and experimental result is as follows:
。
Claims (6)
1. an injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is made up of diclofenac sodium, lidocaine hydrochloride, Macrogol 4000, disodium edetate, anhydrous sodium sulfite, qs pH adjuster, and described pH adjusting agent is sodium carbonate and/or hydrochloric acid.
2. injection diclofenac sodium lidocaine hydrochloride freeze-dried powder according to claim 1, it is characterized in that, each ingredients weight parts proportioning is as follows:
Ingredients weight parts
Diclofenac sodium 75,
Lidocaine hydrochloride 20, in lignocaine,
Macrogol 4000 150 ~ 250,
Disodium edetate 0.1 ~ 0.3,
Anhydrous sodium sulfite 2 ~ 4,
PH adjusting agent is appropriate;
Described qs pH adjuster is in order to regulate the pH of described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder final solution in preparation process 8.5 ~ 9.5.
3. injection diclofenac sodium lidocaine hydrochloride freeze-dried powder according to claim 2, it is characterized in that, each ingredients weight parts proportioning is as follows:
Ingredients weight parts
Diclofenac sodium 75,
Lidocaine hydrochloride 20, in lignocaine,
Macrogol 4000 200,
Disodium edetate 0.2,
Anhydrous sodium sulfite 3,
PH adjusting agent is appropriate.
4. injection diclofenac sodium lidocaine hydrochloride freeze-dried powder according to claim 2, is characterized in that, described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder is prepared from by the raw material of following weight:
Parts by weight of raw materials
Diclofenac sodium 75,
Lidocaine hydrochloride 20, in lignocaine,
Macrogol 4000 150 ~ 250,
Disodium edetate 0.1 ~ 0.3,
Anhydrous sodium sulfite 2 ~ 4,
Water for injection 2500 ~ 3500
PH adjusting agent is appropriate;
In described pH adjusting agent, the amount of water is not counted in the consumption of feed injection water.
5. injection diclofenac sodium lidocaine hydrochloride freeze-dried powder according to claim 4, is characterized in that, described injection diclofenac sodium lidocaine hydrochloride freeze-dried powder, is prepared from by the raw material of following weight:
Parts by weight of raw materials
Diclofenac sodium 75,
Lidocaine hydrochloride 20, in lignocaine,
Macrogol 4000 200,
Disodium edetate 0.2,
Anhydrous sodium sulfite 3,
Water for injection 3000
PH adjusting agent is appropriate.
6. a preparation method for the injection diclofenac sodium lidocaine hydrochloride freeze-dried powder described in claim 4 or 5, its step is as follows:
(1) various raw material, adjuvant is taken, for subsequent use;
(2) in Agitation Tank, add the water for injection of 65% of formula ratio and be cooled to 40 DEG C ~ 60 DEG C, add the Macrogol 4000 of formula ratio, diclofenac sodium puts in Agitation Tank, stirring makes it dissolve completely, be 11.0-12.0 with the sodium carbonate liquor of 10wt% and/or 0.1M hydrochloric acid adjust pH, obtain medicinal liquid A;
(3) water for injection of 20% of formula ratio is cooled to 20 DEG C ~ 28 DEG C, the lidocaine hydrochloride adding formula ratio stirs and makes it dissolve, then adds anhydrous sodium sulfite and disodium edetate and stir and make it dissolve completely, obtains medical liquid B;
(4) medical liquid B is added in medicinal liquid A, stir, mixing, between the sodium carbonate liquor under agitation using 10wt% and/or 0.1M hydrochloric acid adjust pH to 8.5 ~ 9.5, add residue water for injection;
(5) needle-use activated carbon is added in the ratio of 0.03% w/w, mixing; Circulating filtration 30 minutes while stirring, via hole diameter is 0.45 μm, 0.22 μm micropore filter element filtering decarbonization successively, sampling, is transported in surge tank again after inspection intermediates content is qualified through bottling department 0.22 μm of micropore filter element fine straining, stand-by;
(6) fill: calculate loading amount according to intermediates content, fill is in injection bottles made of glass tubes;
(7) lyophilization, roll and cover to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410647421.3A CN104434893A (en) | 2014-11-14 | 2014-11-14 | Diclofenac sodium lidocaine hydrochloride freeze-dried powder injection for injection and preparation method of freeze-dried powder injection |
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| CN201410647421.3A CN104434893A (en) | 2014-11-14 | 2014-11-14 | Diclofenac sodium lidocaine hydrochloride freeze-dried powder injection for injection and preparation method of freeze-dried powder injection |
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| CN104434893A true CN104434893A (en) | 2015-03-25 |
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| CN201410647421.3A Pending CN104434893A (en) | 2014-11-14 | 2014-11-14 | Diclofenac sodium lidocaine hydrochloride freeze-dried powder injection for injection and preparation method of freeze-dried powder injection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213122A (en) * | 2017-07-23 | 2017-09-29 | 南京正宽医药科技有限公司 | A kind of injection omeprazole sodium freeze drying powder injection and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689561A (en) * | 2004-04-30 | 2005-11-02 | 济南百诺医药科技开发有限公司 | Freeze dry preparation containing diclofenac salt and lidocaine and its preparation method |
| CN101485650A (en) * | 2009-02-19 | 2009-07-22 | 山东鲁抗辰欣药业有限公司 | Diclofenac sodium and lidocaine hydrochloride injection and preparation method thereof |
| CN104027315A (en) * | 2014-06-16 | 2014-09-10 | 海南中玉药业有限公司 | Submicron emulsion freeze-dried preparation of diclofenac sodium lidocaine hydrochloride as well as preparation method and application of submicron emulsion freeze-dried preparation |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689561A (en) * | 2004-04-30 | 2005-11-02 | 济南百诺医药科技开发有限公司 | Freeze dry preparation containing diclofenac salt and lidocaine and its preparation method |
| CN101485650A (en) * | 2009-02-19 | 2009-07-22 | 山东鲁抗辰欣药业有限公司 | Diclofenac sodium and lidocaine hydrochloride injection and preparation method thereof |
| CN104027315A (en) * | 2014-06-16 | 2014-09-10 | 海南中玉药业有限公司 | Submicron emulsion freeze-dried preparation of diclofenac sodium lidocaine hydrochloride as well as preparation method and application of submicron emulsion freeze-dried preparation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213122A (en) * | 2017-07-23 | 2017-09-29 | 南京正宽医药科技有限公司 | A kind of injection omeprazole sodium freeze drying powder injection and preparation method thereof |
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